Podcast appearances and mentions of michelle chang

Michelle Chang and her husband, Jedd, didn't set out to become "intentional" travelers, but traveling captured them and if you're going to travel, intentional is a great idea. In this episode Michelle explains Why we need some level of digital/phone literacy to travel well nowadays Preparing our phone before travel Good apps to have Crossing borders Tricks to make travel much smoother, cost-effective, and enjoyable Other things mid-life women should consider before going global Lots of great tips in this episode, and even more great resources at their website. Find Michelle at https://intentionaltravelers.com/ Learn more about Michelle and find all her links at https://boomwithabang.com/the-boomer-womans-podcast-michelle-chang/  

Send us a Text Message.No one travels these days without their phone. So, it makes sense to invest in some extra smartphone skills that can significantly enhance your travel experience if Vietnam.In this show we arm you with some of the best Tech Tips and Apps to enhance your experience of Vietnam, including : staying in touch with family and friends back home; Not getting caught out with home country phone fees; saving money on tour costs: feeling confident about exploring outer regions, and finding a buddy may be a great way to enhance your stay.In this podcast episode, I am joined by Michelle Chang from Intentional Travellers, a business offering tutorials in Smart phone upskilling for travel to countries all around the world. Through Michelle's worldwide travel experiences she is able to explain the benefits of having these skills and how they can help travellers answer unexpected questions, deal with challenges, and navigate unfamiliar places more effectively. Michelle highlights the significance of using essential apps such as Google Maps, Google Translate, WhatsApp, and ride-sharing apps like Grab. Additionally, we cover;-* Currency conversions Apps *Phone battery management *Making the best use of Google Maps*Data management *The GRAB advantages*Working remotely in Vietnam*Online booking tools and Apps to get the best offers*Using your phone to manage communication with tour operatorsMoreover, the conversation on remote work in Vietnam highlights the robust internet connectivity and the extensive use of technology for business. Michelle notes the widespread availability of free Wi-Fi in cafes and co-working spaces. emphasizing the increasing appeal of digital nomadism. By utilizing smartphone modern technology, travelers can effortlessly integrate work with leisure, maintaining productivity while discovering new destinations.Find out more about Michelle's tutorials and online programs you can connect directly with her here - https://intentionaltravelers.com/For a great experience with a buddy to help you enjoy local areas, business situations, translations and possibly medical appointments, why not book a Travel Buddy through https://www.tubudd.com/ Use the Promo code KERRYVN5 on the  TUBUDD App to receive 5% discount. Thank you for listening. Give us a review on your podcast channel - Apple is easiest.Follow our social pages on FB, IG,LinkedIn and TikTokLet me design your customised private tour of Vietnam - See our new Travel ServicesWe have a new partnership which is helping support this podcast. If you have a Dental Procedure why not find out what's possible through What About Vietnam's beauty travel partner Worldwide Beauty Hospital. Check out our website here, contact us direct; speak to Kelley at WAV, as she has been a dental patient for 10 years, or mention #whataboutvietnam to receive 5% discount at Worldwide Beauty Hospital What have you got to lose? Get your FREE consult today.

Welcome to episode 24 of the Global Travel Planning Podcast! In this week's episode, we dive into the fascinating world of full-time travel with our special guest, Michelle Chang. Michelle, a digital nomad and travel expert, joins us to share her journey from a traditional career to a life of travel and adventure with her husband. We'll explore her experiences in the Peace Corps in Jamaica, crafty travel hacks like house sitting, and her love for destinations like Vietnam, Ecuador, and Tuscany. Plus, Michelle will reveal essential smartphone tools and online resources to make your travel planning smoother and more efficient. Whether you're a seasoned traveller or just dreaming of exploring the globe, you won't want to miss Michelle's invaluable insights and tips. So sit back, relax, and get ready for an inspiring conversation on making the most of your travel adventures. Happy listening!⭐️ Guest - Michelle from Intentional Travelers

In episode 17 of the Global Travel Planning Podcast, Tracy Collins chats with guest Michelle Chang from the Intentional Travelers website. Michelle shares her wealth of knowledge on how to make full use of Google Maps for trip planning and navigation. Michelle's expertise in utilising Google Maps will revolutionise how you plan and execute your travels, from finding lesser-known places to using search filters, street views, and reviews. Join Tracy and Michelle as they explore the functionalities and features of Google Maps. Also, get a sneak peek into Michelle's course, Google Maps Travel Hacks, designed to help you become a savvy and confident traveller. Don't miss out on this insightful and practical episode for all wanderlusts and travel enthusiasts.Guest - Michelle Chang from Intentional TravelersShow Notes - Episode 17

In this episode of the UK Travel Planning Podcast, Tracy Collins sits down with guest Michelle Chang to delve into the world of flight booking. As an experienced world traveller, Michelle shares her expert tips on how to book better flights, emphasizing the importance of flexibility, using Google Flights effectively, and uncovering hidden cost-saving strategies. With practical insights and valuable advice, Michelle guides listeners through the intricacies of optimizing flight options and reveals common pitfalls to avoid.  Stay tuned as she provides a special discount for the "Book Better Flights" course, ensuring that travellers can maximise their flight booking endeavours. Tune in to discover how to secure the best travel deals and plan your next UK adventure quickly and confidently!⭐️ Guest -Michelle Chang of Intentional Travelers

During our "Saturday Mornings Sit-Down" conversation Part 2... Saturday Mornings host Glenn van Zutphen and co-host, award-winning author Neil Humphreys look at the state of Singapore's film industry: talent, costs, funding, and what it will take to make it a truly global competitor. We discuss with Director Chai Yee Wei, Michelle Chang, Producer & Writer, and veteran actor Peter Yu - all of the award-winning 2023 film "Wonderland."See omnystudio.com/listener for privacy information.

During our "Saturday Mornings Sit-Down" conversation Part 1… Saturday Mornings host Glenn van Zutphen and co-host, award-winning author Neil Humphreys discuss the award-winning Singaporean film “Wonderland”l with the film's Director Chai Yee Wei, Michelle Chang the Producer & Writer, and veteran actor Peter Yu. The 2023 film won the Local Jury Award at the Palm Springs International Film Festival and the Best Audience Award at San Diego Asian Film Festival.See omnystudio.com/listener for privacy information.

FB粉專 影片 https://reurl.cc/ZWeeN6 YouTube 影片 https://reurl.cc/r599Yy 本集主題：從法國再回到台灣的發酵料理 訪問：張怡 Michelle Chang 主廚 Cheffe Michelle Chang是台灣人。 她在台灣當了25年的老師，後來因爲家庭的因素於2012年定居法國。 她繼承了她的母親--一位廚師和父親--一位藝術家的天賦，來到法國後，成為一位廚師。 2017年她創建了自己的料理品牌 - Michelle Chang-La 5ème Saveur，這是一個在法國誕生的新料理。 Michelle在2014年開始了對發酵的研究，因為她懷念母親烹飪的美味。 從2014年開始，Michelle閱讀許多關於發酵、烹飪、醫藥、營養…… 的書籍和論文，並且實作發酵食品。經過多年的研究， 她發現，通過控制溫度，可以保留微生物酶，並在烹飪過程中繼續發酵。發酵過程中產生的微生物酶可以預先分解食材中的醣類、蛋白質、脂肪和纖維素。 Michelle發現，如果烹飪與發酵相結合，可以使味道更豐富，更有層次感，而且食用後更容易消化。 2017年，Michelle在法國Quimperlé開設了她的La 5ème Saveur餐廳，這是法國第一家以發酵為基礎的餐廳，將這種控制微生物酶活性的低溫方法與法國菜和其他烹飪元素相結合，創造了Michelle Chang-La 5ème Saveur NEW CUISINE。 自開業以來，La 5ème Saveur餐廳得到了顧客非常好的評價，是當時Tripadvisor網站上Quimperlé排名第一的餐廳。 然而，受限於餐廳位置不顯眼，菜品概念先進，加上Cheffe Michelle的亞洲面孔，大多數當地人把Michelle Chang-La 5ème Saveur歸為亞洲菜，這使得它難以發展。 直到2018年，蜜雪兒參加了一個大型烹飪比賽 “Talents-Gourmands”，並得到了當時的首席評委Frédéric Claquin大廚（Les Trois Rochers米其林一星級餐廳的主廚）的讚揚。 Chef Frédéric Claquin說：Michelle的料理領先於時代10年“ 此後，她逐漸嶄露頭角。 2019年，Michelle被列入《Cheffes》--500位使料理與眾不同的女主廚。 （ Editions NOURITURFU）一書中。 2019年11月，她返回台灣做了一場小型的演講分享會，並輔導一家蔬食餐廳發酵米麴，製作鹽麴，味噌，運用在他們的蔬食料理中。並且也指導他們發酵飲料：康普茶和水克非爾，除了提供客人內用外也可以外帶。 2020年，Michelle和她的商業夥伴將餐廳遷移到Pont-Aven，Pont-Aven是一個國際旅遊城市，以埃米爾-伯納德和保羅-高更等藝術家組成的阿旺橋派而聞名。Michelle Chang- La 5ème Saveur的新料理不僅受到法國人的歡迎，也受到國際旅行者的讚賞，其中許多人甚至連續兩個夏天都來到Michelle的餐廳用餐。 2021年，Michelle出版了她的第一本書--《Ma cuisine fermentée》，並登錄在法國國家圖書館。 2022年3月，Michelle接到美國Charlottesville市的Kyoto餐廳邀請，幫助他們將原有的料理轉型為發酵日本料理。 2022年5月，Michelle關閉了她的餐廳，因為她想去旅行，繼續她的使命。 對她來說，最重要的事情是發展這種健康料理的概念。她想成為一名顧問。 2022年6月，她來到Charlottesville市，7月，Kyoto餐廳改名為Kyoto 5th Taste餐廳，展現一個健康料理的新面貌。 Cheffe Michelle把她的新料理從法國帶到了美國，她期待著把它帶到世界的各個角落。 2022年底，Cheffe Michelle Chang 回到台灣，她的家鄉，有時候在法國。她開始了另一個旅程-成為一位食物療癒師。 在她的工作坊裡，她是一位主廚，一位老師,也是一位療癒師。透過料理，她將愛的能量傳達。在她的餐桌上，除了食物的美味外，還有流動在空間裡的愛。 台灣是她的家，她的基地，法國是她的另一個家。美國是一個新世界。未來,她會在各地旅行或透過線上的教學來繼續她的發酵料理，哲學和愛。 #李基銘#李基銘主持人#fb新鮮事#生活有意思#快樂玩童軍 #廣播之神#廣播之神李基銘#漢聲廣播電台 YouTube頻道，可以收看 https://goo.gl/IQXvzd podcast平台，可以收聽 SoundOn　https://bit.ly/3oXSlmF Spotify　https://spoti.fi/2TXxH7V Apple　https://apple.co/2I7NYVc Google　https://bit.ly/2GykvmH KKBOX　https://bit.ly/2JlI3wC Firstory　https://bit.ly/3lCHDPi 請支持六個粉絲頁 李基銘主持人粉絲頁：https://www.facebook.com/voh.lee 李基銘的影音頻道粉絲頁：https://www.facebook.com/voh.video 廣播之神李基銘：https://www.facebook.com/voh.god Fb新鮮事新聞報粉絲頁：https://www.facebook.com/voh.fbnews 漢聲廣播電台「fb新鮮事」節目粉絲頁：https://www.facebook.com/voh.vhbn 漢聲廣播電台「快樂玩童軍」節目粉絲頁：https://www.facebook.com/voh.scout

It's nice to be surprised...On this episode we dive into the world of the new TV show, 'Blood and Water: Fire & Ice" airing now on Omni Television. It's the story of Anna Xie, the ambitious young daughter of former real estate developer Ron Xie and his wife Weiran, is running a thriving Casino and condo complex in Toronto, Canada. But the Casino's success isn't enough for her. Anna is planning to build a new 60-story condo tower despite knowing how over-leveraged her company is. When Anna's sister-in-law Teresa Fai notices some shady activity at the Casino, suspicion points to notorious money launderer, Norris Pang. Anna hires ex-cop Michelle Chang, now a private investigator, to thwart Pang's efforts. But Michelle is distracted by her own agenda. She is desperately seeking her long-lost daughter Rebecca. Worlds collide when Pang kidnaps Rebecca, holding her hostage and eventually ransoming her in an attempt to get Michelle and Anna to do his bidding. But not before he not only worms his way into Anna's Casino but also into her family's risky condo deal. Every scheme to stop Pang fails until Anna, Michelle and Teresa realize they must join forces and work together to capture Pang and rescue Rebecca. We got the unique pleasure to sit down with show runner Diane Boheme about the origins on the show and so very much more

In today's episode we're chatting with Michelle Chang, a runner, Googler, mother, traveler, and member of the Impalas. Michelle shares her thoughtful 7-phase running journey that began with her playful desire to chase boys and is currently in a recovery phase where she is finding balance with running and motherhood. Some highlights from our conversation:

“Boy” or “Girl”? “He”, “She”, “They”? In this episode, Michelle Chang, MFT, RDT shared her experience in raising her gender-neutral child in an Asian American household. What are we teaching our children when using gender neutral parenting style? What is the psychology behind it? And how does it shift our interactions with the world? Gender Neutral Parenting / Gender Open Parenting / Gender Creative Parenting wavesofchange #podcast #sanfrancisco #america #mentalhealth #asianmentalhealth #therapy #culture #diversity #discussion #asianamerican #genderneutralparenting #genderopenparenting #gendercreativeparenting #asianparents #parenting #earlychildhood #childdevelopment Find out more at https://waves-of-change-modern-perspectives-in-asian-ameri.pinecast.co

I am beyond thankful to this sweet lady, Michelle Chang, for opening up and sharing her challenges through marriage and divorce. No one enters a relationship, let alone a marriage with the expectation of it only lasting several years. However, as we get older I think we are learning that life is not always perfect. Things don't go as planned and we get curve balls thrown at us from time to time that we learn to push through and grow from. Michelle's heartbreak is one many of us I'm sure can relate to. Marriage is hard. Two people choosing to spend their lives together need to be able to openly communicate and always be honest with themselves and one another. Divorce was never planned, but what she took away and learned from it was life-changing. 

We served in Jamaica 2012-14. Michelle did literacy tutoring at a rural primary school while Jedd helped start up a brand new community center in town and taught basic computer classes to senior citizens. [...] The post Jedd and Michelle Chang appeared first on My Peace Corps Story.

After getting married and working for a few years, Michelle and her husband joined the Peace Corps and served together for two years in rural Jamaica. They then tested out location independence while slowly building a freelance web services business, keeping expenses low through house sitting, work exchanges, and other unconventional accommodations. This budget-friendly approach continues to sustain and enrich their long-term travel lifestyle.   In This Episode Living intentionally Learning empathy through travel What to look for in a work exchange Creating local experiences And so much more   See www.nomadtopia.com/138 for show notes plus other interviews, resources, and more. Join the Nomadtopia Collective—an online community making location independence easier, less lonely, and more sustainable—at www.nomadtopia.com/collective.

Michelle Chang’s gorgeous jewelry pieces have exploded in popularity recently and are now stocked at a number of stores and shopping sites both in the U.S. and abroad (you may have seen her jewelry on Fab.com!). We chat about her unusual beginnings as a jewelry designer (she actually started as an illustrator!) and her rapid success in the market, … Read more about this episode...

Ming Hammond is Asst. Professor of Chemistry, Molecular & Cell Biology. Her research combines Chemical and Molecular Biology, Organic Chemistry; Reengineering functional RNAs, and mechanistic studies of RNA-based gene regulation. She created the web site youstem.org.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Okay. Speaker 1: Welcome to spectrum the science and technology show on k a l x Berkeley, a biweekly [00:00:30] 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Good afternoon. My name is Brad swift and I'm your host. Our interview is with assistant professor of chemistry and molecular and cell biology Ming Hammond. Her research combines the fields of chemical biology, organic chemistry, molecular biology and bioinformatics. Ming Hammond [00:01:00] received her bachelor of Science Degree from the California Institute of Technology and her phd from UC Berkeley. She created and maintains the website you stem.org this site consolidates opportunities in science, technology, engineering and math for primary and secondary school students in the Greater Bay area. Assistant Professor Ming Hammond. Welcome to spectrum. Hello. Thank you. Would you give us an overview of [00:01:30] the research that you're doing and in so doing, remind us what DNA and RNA are and how they're different. Speaker 1: Okay. Okay. I think a analogy that I like to use to describe the difference between DNA and RNA is that you can think of DNA as kind of an instruction manual for life. So that a very large instruction manual, several billion letters in length and it has all the instructions for how to make [00:02:00] all of the molecules, all the functioning parts of the cell RNA are messenger RNA is, are basically xerox copies of some pages of the DNA instruction manual that, um, gets used by the cell to translate the instructions into making proteins like enzymes and other components of the cell. Um, my lab is interested in how these RNA sequences are [00:02:30] regulated, how they're sent to different places in the cell and also how to change them so that we have, maybe we can control how the instructions are being used by the cell. Speaker 3: And so with that research, are you trying to create a generally applicable way to alter the RNA so that the gene is expressed differently? Speaker 1: Um, yes, exactly. And [00:03:00] first of all, understanding in nature how natural systems, um, control gene expression. And one reason we're interested in this is because for multicellular organisms like humans or plants, you have the same instruction manual in every single cell and yet you have multicellularity, right? So you have differences, different sets and instructions are being expressed [00:03:30] in different cell types, in different organs and in different portions of plants. For example, and were interested in understanding the basic mechanism for how the Messenger RNA is involved in ensuring that specific instructions are being followed in specific tissue types or specific cell types. Speaker 3: Does that then also include the idea that you mentioned of [00:04:00] certain of the messages are incorrect on purpose and so understanding that sounds complex, Speaker 1: right? So it's kind of interesting that one of the ways in which you can control, for example, whether a specific gene is expressed in the heart versus in the liver or the brain for example, is that messenger RNA for the same gene in the [00:04:30] brain is correct and can give rise to the proper protein and in the heart the same gene set of instructions can be spliced into messenger RNA in this specific way. That gives you a slightly different form of the protein. For example, one that has a slightly different function and therefore specific for that tissue. And then in the other case that I described, you might find in yet another tissue type that the same [00:05:00] message can be spliced so that it actually has a signal that says this is a garbage sequence, this is a nonsense message, don't follow this message. And the sal is smart enough to read these nonsense messages and know them to be nonsense. And what they do is the cell actually degrades these RNA. So for example, in that specific tissue type that the protein is never made. And so that's how you get [00:05:30] specialization of self. Speaker 3: And in your research are you trying to understand all of those cases? Speaker 1: We do most of our work in plants and we're very interested in the case where you can effectively shut off Accion in one condition, in war one cell type versus having it on or expressed in another cell type. So in plants, the mechanism that we study is [00:06:00] how these messages are lysed in these different ways. And that's called alternative splicing. And the predominant function of alternative spicing and plants appears to be this latter case where the messages either made and it's correct or it's made and has nonsense, but the reason I mentioned the other case is that it turns out something that's differentiates humans, for example, or mammals from plants. Besides the obvious differences, but a subtle [00:06:30] difference. The one I'm interested in is it turns out the majority of alternative splicing in mammals is actually to make different forms of that protein, so it's kind of interesting how the same basic mechanism is used by different organisms to do different things. Speaker 4: [inaudible]Speaker 3: you were listening to spectrum on k a l x Berkeley. Today we're talking with assistant professor Ming Hammond about [00:07:00] her work in messenger RNA and gene expression Speaker 4: [inaudible]Speaker 3: does the nonsense message have some value that you are researching that you are interested in understanding what is, what is the value of it to the, to the organism. Speaker 1: Okay. It's very important for the organism in general that the cell needs to have a way to know when a message or when a messenger RNA is [00:07:30] instructing nonsense because it's actually known that you can have mutations, for example, if you have a mutation in your gene that gives you a bad message. If sometimes that message then gets expressed as a protein, that protein with this altered function or ane may in fact lead to detrimental results, bad results for the south. Right. Um, and so, um, in general, the, there's a, [00:08:00] we call it a surveillance mechanism, so the cell is actually looking out for dad copies of the Messenger RNA. And so the cell normally has these surveillance mechanisms to, to, to play a very important role in keeping the, and keeping the cell healthy. And so I think what has happened is that the cell has started exploiting this mechanism to regulate chains for [00:08:30] tissue specificity and all of these other things I mentioned Speaker 3: in this regard. Are some cells smarter than others? Speaker 1: Hmm. I, I wouldn't say that [inaudible] Speaker 3: in terms of evolutionary activity, it would seem that this is kind of the place where that might go on in terms of changing an organism over time. How would RNA and nonsense allow for some sort of an evolutionary capacity to happen? Speaker 1: Okay. [00:09:00] First of all, the surveillance mechanism does not change the genomic DNA or she does not change the DNA instruction manual. Speaker 3: It's too far down the pipeline, right? So it's just reacting to the DNA instruction set, right? So it's really not there that any evolutionary activity is going to happen. It's going to happen at the higher lows. Right? Speaker 1: There are people that look to see for example, which, uh, which organisms do have this mechanism, right? So it's not that [00:09:30] some cells are smarter than others, but more that there are some organisms that don't have this surveillance pathway, for example. And bacteria do not, as far as we know, have NMD pathways, um, this nonsense mediated decay pathways, but a lot of organisms with a nucleus to have this mechanism. But one of the things that we're interested in in the lab is there is a lot of people that study this mechanism in humans and in other mammals. [00:10:00] And we're working in this in plants and we're looking at the comparison between them. What are the differences and what are the things that are similar Speaker 3: in your research? I noticed that there's something called molecular sensing that you're interested in. Can you explain that? Speaker 1: Sure. So, um, I mentioned that were studying how gene expression is regulated at the RNA level. And one of the really fascinating [00:10:30] things that I worked on as first as a postdoc and now that we're still working on in the lab is it turns out some of the Messenger RNA [inaudible] that exist in bacteria don't just encode the sequences for making proteins. But there is a little extra part of the Messenger RNA in the beginning part of the messenger RNA sequence that encodes what we call a ribo [00:11:00] switch. You can think about the riboswitch as basically a natural chemical sensor that's hooked up to the Messenger RNA. And what the rabis switch does is it responds to the presence of a chemical, for example, whether there is plenty of an amino acid in the south and the RNA is able to sense the presence of say the [00:11:30] amino acid and when it binds to this chemical, it changes its shape and through this confirmation or shape change, it causes the message downstream to actually get shut off. If you have enough of the amino acid, you turn off the gene that is used to make that amino acid because you don't need anymore. So I turns out there are many, many of these rabis switches [00:12:00] performing this simple chemical, boolean logic at the RNA level doing molecular sensing and in my lab were of course interested in the natural, these natural ones. And we're also interested in making unnatural ones as well. Speaker 3: And how is it that you utilize that information? Speaker 1: One way you can make use of the [inaudible] switch as I mentioned, is that its normal function is to turn on or turn off a chain depending on [00:12:30] the natural chemical logic is. So it turns out you can take the DNA sequence that encodes the ribo switch and you could put it in front of a different gene. And now that other gene also responds to this chemical. So it's actually a portable logic gate, so to speak. And what we're interested in is in making new Ribas switches, for example, making ones that can work in plants [00:13:00] because there is so far as we know, only one natural rubber switch that functions in plants and were interested in exploring whether we can transport these chemical sensors and utilize them and in other organisms including plant. Speaker 5: This is spectrum. I'm k a l x Berkeley. We're talking with the assistant professor Ming Hammond [00:13:30] about her research with messenger RNA and how it interacts with DNA genes. [inaudible] Speaker 3: so are you building those pre-IPO switches yourself or are you borrowing them from other organisms? Speaker 1: Um, well I would say it's actually a mix of both. We are also fundamentally interested in the mechanics of it too, right? How, how riboswitch with dysfunction. What is really amazing about Rabis, which is [00:14:00] is that there are so many different species of bacteria that utilize these Ribas switches and these bacteria live in all different types of climates than of them can live in extreme temperatures, both hot and cold and others are more, you know, soil dwelling organisms and live at pretty close to room temperature and all of them have the same sensor. And it's kind of an interesting question to ask how it is that the same sensor works [00:14:30] in all of these organisms? What part of the sequence of the, the switch of the RNA is responsible for for that [inaudible]. Speaker 3: So largely you, you work from the gene DNA area down into the RNA to control the expression of that gene. Speaker 1: Everything that we do does start the DNA level and we have in mind and designed for messenger RNA that we want. And then we can go back and say, okay, [00:15:00] at the DNA level, this is what the DNA instructions have to be to make that messenger RNA. And then we see, okay, let's build it weak. Then express it and see, okay, is the RNA doing? What we want it to and then further on is this messenger RNA being shut off the way that we want it to under this condition and then turned on under a different set of conditions. Speaker 3: And how do you judge whether or not you've had success? Is it pretty black and white [00:15:30] or is it somewhat gray? Speaker 1: One of the kind of very basic techniques that we use is a very simple assay. So you can imagine if we wanted to see whether under condition a this messenger RNA we designed is not making the protein versus condition B when when it is. So what we ended up using is what we call a reporter gene, a gene that expresses a protein that is fluorescent so that if [00:16:00] you shine light at a certain wavelength, you get a light emission from this protein. So we express the gene and in this case on the surface of the plant leaf and we can scan the leaf and let's say condition a is on the left hand side and condition B is on the right hand side. And we'll actually see that the right hand side, the leaf will be glowing and the left hand side of leaf not be glowing because of Ganar that we use to tact [00:16:30] the light emission from the surface of the leaf. Uh, it actually shows up as a gray scale limit. So that's how it turns out. Speaker 3: The organisms that you're currently working with, how do you select them? Speaker 1: One of the ways that you would want to select an organism is, is that other people have worked with the organism and that it's been shown by other researchers that it's easy to do the experiments that you're planning and that there are protocols developed for the experiments [00:17:00] that you're planning. And so it's kind of expedient, but we pick a plant called Nicole [inaudible], Tami Ana that is actually cousin to the tobacco plant, which is of some agricultural interests and also has been shown by other people to be very easy to work with for our experiments. Speaker 3: How has the hardware and the software that you use to do your research changed over the past? What 10 years that you've been doing this [inaudible] Speaker 1: [00:17:30] so we don't actually use much software. We can talk about the hardware. Sure we can like the development of technology to do DNA sequencing very, very rapidly has really been astonishing to see. And for my research in the RNA field, it has an equal impact I would say as well because it turns out if you want to study an RNA sequence, one of the ways we study it is that we do what's called a [00:18:00] reverse transcription. So we convert the RNA back to DNA and then we sequence the DNA that's made from the RNA. So it's kind of the reverse of the normal case of things that technology has enabled people to not just look at the human genome, but what we called a human transcriptome. So this is what are all the Messenger RNHS that are being expressed in different tissue types. And so that has led us to discovering, for [00:18:30] example, these differences in expression at different, um, messenger RNA is on a much, much grander scale. It much, much higher throughput scale than was possible 10 15 years ago. More fundamentally, it has made certain experiments that were impossible to do possible. Now the next challenge is how to sort through all that data Speaker 6: [inaudible]Speaker 5: you are tuned to k a l [00:19:00] x Berkeley. You're listening to spectrum. We're talking with Assistant Professor Mang Hammond about RNA based gene regulation Speaker 6: [inaudible].Speaker 1: Can you explain the a youth stem.org website and I believe you started this, didn't right. So my lab and I started this website called youth stem.org and the inspiration for the website is, it's actually kind of a personal story, [00:19:30] but I think it resonates with a lot of young scientists and other scientists is when I was a younger student, even before I went off to college and I was deciding what subjects I liked, what I like to do, I had these opportunities where yes, some of my science teachers saw something in me or thought that I would enjoy science and wanted to encourage me in the sciences and they would suggest that I go and do some of these programs that [00:20:00] are available in the state of Maryland, for example, where my family is from. And you know, I had a chance to work in a lab at the University of Maryland School of Pharmacy. Speaker 1: And I remember that made a really big impression on me when I was a freshman in college. And my freshman advisor asked me what I wanted to do for work study. I said that, well of course I wanted to do research in a lab because I said why I was already in a lab and in high school and I really liked it [00:20:30] and that's what I want to do for work study. And it was really exciting and really fun. So that's the origin story I guess of you stem. And in fact we have a lot of programs on the Berkeley campus for students interested in science that are, and that some of which pay actually a stipend. And not everyone can afford to pay money to do a summer program, but we have these free programs [00:21:00] that are I think really great. So I wanted to have a mechanism to point that out to local area students. Speaker 1: And the kind of idea I had was, well wouldn't it be great if we had like essentially a craigslist for bay area free local science and engineering and math programs? And so that's um, basically what we intend for a stem to be. [00:21:30] You can actually go on the website. It's you stem.org and you can click on a subject. You know, my favorite subject of course is chemistry. And so you could pick chemistry and it'll actually show you just the programs that are for students interested in chemistry. You can search by your grade and it tell you which programs are for you or you also filter by the location. So we're focused a lot on the East Bay, but there are also programs down in the South Bay down [00:22:00] in San Jose, Santa Cruz that we found in ones up in Monterrey. Speaker 3: So for people locally within the bay area who do have programs, they could contact you through the web. Speaker 1: Right? There's actually a link on the bottoms saying you're saying if you're a program director and you would like to list your program, the criteria is that we're interested in listing programs where the students can apply themselves or it can be nominated by a teacher that it's open to [00:22:30] any student that wants to apply. And uh, certainly we emphasize programs that are free or that pass state band. Speaker 3: And you recently received the NIH director's new innovator award. How did that happen? Speaker 1: Well, the short answer is I applied but um, yes. So it's, it's a really great honor to have received it and actually [00:23:00] to a members of the chemistry department received the new innovator where I this year, myself and Michelle Chang, another assistant professor in the same department. And so it, that was just really great news for both of us. And yeah, it was really a day for celebration in the lab for sure. I mean Hammon thanks very much for coming on spectrum. Thank you. It's a pleasure to be here. Thanks for having me. Brad. Speaker 6: [inaudible]Speaker 3: [00:23:30] irregular feature of spectrum is to mention a few of the science and technology events happening locally over the next few weeks. Rick Kaneski joins me for the calendar. Speaker 7: Come to nerd night [00:24:00] on Wednesday, January 18th at the rickshaw stop, one 55 [inaudible] street at Venice in San Francisco, doors at seven 30 show at eight. All ages are welcome to this $8 show at this month and our night copies of the inaugural issue of nerd night magazine will be given away. There's an article in there about cephalopod sex by the bay area's own. Rich Ross, Robyn, sue Fisher and Corey bloom will share their stories of liquid nitrogen ice cream. Their company smitten in San Francisco's first [00:24:30] made to order scoop shop and they will show off the engineering marvel that is dubbed to Kelvin that can churn up ice cream in under a minute. What do you love? Bounty and David Gallagher. We'll present Carville by the sea. San Francisco's Streetcar, suburb, and you CSF, Phd Student Tsai. Dear Etsy, we'll talk about antibody engineering and how artificially created antibodies can or will eventually fight disease. Visit s F. Dot. [inaudible] dot com for more information, Speaker 3: smoke [00:25:00] and mirrors is geoengineering a solution to global warming. Professor Alan Robock from the Department of Environmental Sciences at Rutgers University will address this question. Wednesday, January 25th 4:00 PM in Barrels Hall Room One 10 on the UC Berkeley campus. This event is free and open to the public Speaker 7: on Thursday, January 26th from seven to 9:00 PM the bone room at 1573 Solano avenue in Berkeley or present [00:25:30] eye to compound eye, the art and science of insect photography. In this free lecture insect photographer Becky Jaffe will incorporate and it dotes from biology, ecology and cultural anthropology to offer an engaging account of her field experiences that will inspire you to pick up the camera and look at insects with new eyes. Visit www.boneroompresents.com for more information now a few news items. Here's the Rick science [00:26:00] news reviews. A January 5th article in science by Sandra Garrett and Joshua Rosenthal at the University of Puerto Rico Medical Sciences campus in San Juan that shows that while octopuses in the Arctic have very similar DNA with warm water octopuses, their nerve cells are very different. This difference allows them to operate in the frigid waters and arises due to m RNA edits. These edits change the way that nerve cells opening includes gates to produce electrical impulses based on the species of octopus. This is the first [00:26:30] discovered example of m RNA editing to help an organism adapt to its environment and speculation remains as to how quickly and prevalent the mechanism might be. Speaker 3: In December, NASA announced seventh 2012 as the new target launch date for the space x commercial orbital transportation services milestone missions two and three. This mission begins with the liftoff of the Falcon nine rocket from Cape Canaveral boosting the Dragon's [00:27:00] spacecraft into low earth orbit. The space x dragon spacecraft will perform all of the commercial orbital transportation services, milestone mission two objectives, which include numerous operations in the vicinity of the International Space Station, and thereafter we'll perform the commercial orbital transportation services milestone mission three objectives. These include approach birthing with the International Space Station, astronauts opening the dragon spacecraft [00:27:30] and unloading cargo. Finally, the astronauts will close the space craft and send it back to Earth for recovery from the Pacific Ocean off the coast of California. This mission, if successful, will mark a major milestone in commercial American space flight Speaker 7: did January 4th issue of the Journal of neuroscience has an article by UCLA is Jenn Lang and others that reports promising anti-alcohol effects of a seed extract from the Asian Havana Dakis or Japanese [00:28:00] raising tree. This was first claimed to be a hangover remedy in the year six five nine rats that took dihydro, Myostatin or [inaudible] were found to take longer to become intoxicated and recovered four times more quickly than rats who did not take the extract. The extract further decrease the likelihood of hangover, anxiety and seizures in the rats. DSM also curved alcohol consumption. Rats consumed more and more alcohol gradually when it allowed, but d h m leased alcohol does not lead to this increased [00:28:30] consumption. DHM blocks alcohol's effects on Gaba receptors and the team has found no side effects in animal testing. They old next study the health effects on people Speaker 2: [inaudible]Speaker 4: the music heard during the show is from a low stone, a David album titled Folk and Acoustic released under a creative Commons attribution license 3.0 Speaker 2: [00:29:00] [inaudible] Speaker 4: production assistance from Rick Karnofsky Speaker 2: [inaudible].Speaker 4: Thank you for listening to spectrum. We are happy to hear from listeners. If you have comments about the show, please send them to us via email. [00:29:30] Our email address is spectrum dot k l x@yahoo.com join us in two weeks at the same time. [inaudible]. See acast.com/privacy for privacy and opt-out information.

Ming Hammond is Asst. Professor of Chemistry, Molecular & Cell Biology. Her research combines Chemical and Molecular Biology, Organic Chemistry; Reengineering functional RNAs, and mechanistic studies of RNA-based gene regulation. She created the web site youstem.org.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Okay. Speaker 1: Welcome to spectrum the science and technology show on k a l x Berkeley, a biweekly [00:00:30] 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Good afternoon. My name is Brad swift and I'm your host. Our interview is with assistant professor of chemistry and molecular and cell biology Ming Hammond. Her research combines the fields of chemical biology, organic chemistry, molecular biology and bioinformatics. Ming Hammond [00:01:00] received her bachelor of Science Degree from the California Institute of Technology and her phd from UC Berkeley. She created and maintains the website you stem.org this site consolidates opportunities in science, technology, engineering and math for primary and secondary school students in the Greater Bay area. Assistant Professor Ming Hammond. Welcome to spectrum. Hello. Thank you. Would you give us an overview of [00:01:30] the research that you're doing and in so doing, remind us what DNA and RNA are and how they're different. Speaker 1: Okay. Okay. I think a analogy that I like to use to describe the difference between DNA and RNA is that you can think of DNA as kind of an instruction manual for life. So that a very large instruction manual, several billion letters in length and it has all the instructions for how to make [00:02:00] all of the molecules, all the functioning parts of the cell RNA are messenger RNA is, are basically xerox copies of some pages of the DNA instruction manual that, um, gets used by the cell to translate the instructions into making proteins like enzymes and other components of the cell. Um, my lab is interested in how these RNA sequences are [00:02:30] regulated, how they're sent to different places in the cell and also how to change them so that we have, maybe we can control how the instructions are being used by the cell. Speaker 3: And so with that research, are you trying to create a generally applicable way to alter the RNA so that the gene is expressed differently? Speaker 1: Um, yes, exactly. And [00:03:00] first of all, understanding in nature how natural systems, um, control gene expression. And one reason we're interested in this is because for multicellular organisms like humans or plants, you have the same instruction manual in every single cell and yet you have multicellularity, right? So you have differences, different sets and instructions are being expressed [00:03:30] in different cell types, in different organs and in different portions of plants. For example, and were interested in understanding the basic mechanism for how the Messenger RNA is involved in ensuring that specific instructions are being followed in specific tissue types or specific cell types. Speaker 3: Does that then also include the idea that you mentioned of [00:04:00] certain of the messages are incorrect on purpose and so understanding that sounds complex, Speaker 1: right? So it's kind of interesting that one of the ways in which you can control, for example, whether a specific gene is expressed in the heart versus in the liver or the brain for example, is that messenger RNA for the same gene in the [00:04:30] brain is correct and can give rise to the proper protein and in the heart the same gene set of instructions can be spliced into messenger RNA in this specific way. That gives you a slightly different form of the protein. For example, one that has a slightly different function and therefore specific for that tissue. And then in the other case that I described, you might find in yet another tissue type that the same [00:05:00] message can be spliced so that it actually has a signal that says this is a garbage sequence, this is a nonsense message, don't follow this message. And the sal is smart enough to read these nonsense messages and know them to be nonsense. And what they do is the cell actually degrades these RNA. So for example, in that specific tissue type that the protein is never made. And so that's how you get [00:05:30] specialization of self. Speaker 3: And in your research are you trying to understand all of those cases? Speaker 1: We do most of our work in plants and we're very interested in the case where you can effectively shut off Accion in one condition, in war one cell type versus having it on or expressed in another cell type. So in plants, the mechanism that we study is [00:06:00] how these messages are lysed in these different ways. And that's called alternative splicing. And the predominant function of alternative spicing and plants appears to be this latter case where the messages either made and it's correct or it's made and has nonsense, but the reason I mentioned the other case is that it turns out something that's differentiates humans, for example, or mammals from plants. Besides the obvious differences, but a subtle [00:06:30] difference. The one I'm interested in is it turns out the majority of alternative splicing in mammals is actually to make different forms of that protein, so it's kind of interesting how the same basic mechanism is used by different organisms to do different things. Speaker 4: [inaudible]Speaker 3: you were listening to spectrum on k a l x Berkeley. Today we're talking with assistant professor Ming Hammond about [00:07:00] her work in messenger RNA and gene expression Speaker 4: [inaudible]Speaker 3: does the nonsense message have some value that you are researching that you are interested in understanding what is, what is the value of it to the, to the organism. Speaker 1: Okay. It's very important for the organism in general that the cell needs to have a way to know when a message or when a messenger RNA is [00:07:30] instructing nonsense because it's actually known that you can have mutations, for example, if you have a mutation in your gene that gives you a bad message. If sometimes that message then gets expressed as a protein, that protein with this altered function or ane may in fact lead to detrimental results, bad results for the south. Right. Um, and so, um, in general, the, there's a, [00:08:00] we call it a surveillance mechanism, so the cell is actually looking out for dad copies of the Messenger RNA. And so the cell normally has these surveillance mechanisms to, to, to play a very important role in keeping the, and keeping the cell healthy. And so I think what has happened is that the cell has started exploiting this mechanism to regulate chains for [00:08:30] tissue specificity and all of these other things I mentioned Speaker 3: in this regard. Are some cells smarter than others? Speaker 1: Hmm. I, I wouldn't say that [inaudible] Speaker 3: in terms of evolutionary activity, it would seem that this is kind of the place where that might go on in terms of changing an organism over time. How would RNA and nonsense allow for some sort of an evolutionary capacity to happen? Speaker 1: Okay. [00:09:00] First of all, the surveillance mechanism does not change the genomic DNA or she does not change the DNA instruction manual. Speaker 3: It's too far down the pipeline, right? So it's just reacting to the DNA instruction set, right? So it's really not there that any evolutionary activity is going to happen. It's going to happen at the higher lows. Right? Speaker 1: There are people that look to see for example, which, uh, which organisms do have this mechanism, right? So it's not that [00:09:30] some cells are smarter than others, but more that there are some organisms that don't have this surveillance pathway, for example. And bacteria do not, as far as we know, have NMD pathways, um, this nonsense mediated decay pathways, but a lot of organisms with a nucleus to have this mechanism. But one of the things that we're interested in in the lab is there is a lot of people that study this mechanism in humans and in other mammals. [00:10:00] And we're working in this in plants and we're looking at the comparison between them. What are the differences and what are the things that are similar Speaker 3: in your research? I noticed that there's something called molecular sensing that you're interested in. Can you explain that? Speaker 1: Sure. So, um, I mentioned that were studying how gene expression is regulated at the RNA level. And one of the really fascinating [00:10:30] things that I worked on as first as a postdoc and now that we're still working on in the lab is it turns out some of the Messenger RNA [inaudible] that exist in bacteria don't just encode the sequences for making proteins. But there is a little extra part of the Messenger RNA in the beginning part of the messenger RNA sequence that encodes what we call a ribo [00:11:00] switch. You can think about the riboswitch as basically a natural chemical sensor that's hooked up to the Messenger RNA. And what the rabis switch does is it responds to the presence of a chemical, for example, whether there is plenty of an amino acid in the south and the RNA is able to sense the presence of say the [00:11:30] amino acid and when it binds to this chemical, it changes its shape and through this confirmation or shape change, it causes the message downstream to actually get shut off. If you have enough of the amino acid, you turn off the gene that is used to make that amino acid because you don't need anymore. So I turns out there are many, many of these rabis switches [00:12:00] performing this simple chemical, boolean logic at the RNA level doing molecular sensing and in my lab were of course interested in the natural, these natural ones. And we're also interested in making unnatural ones as well. Speaker 3: And how is it that you utilize that information? Speaker 1: One way you can make use of the [inaudible] switch as I mentioned, is that its normal function is to turn on or turn off a chain depending on [00:12:30] the natural chemical logic is. So it turns out you can take the DNA sequence that encodes the ribo switch and you could put it in front of a different gene. And now that other gene also responds to this chemical. So it's actually a portable logic gate, so to speak. And what we're interested in is in making new Ribas switches, for example, making ones that can work in plants [00:13:00] because there is so far as we know, only one natural rubber switch that functions in plants and were interested in exploring whether we can transport these chemical sensors and utilize them and in other organisms including plant. Speaker 5: This is spectrum. I'm k a l x Berkeley. We're talking with the assistant professor Ming Hammond [00:13:30] about her research with messenger RNA and how it interacts with DNA genes. [inaudible] Speaker 3: so are you building those pre-IPO switches yourself or are you borrowing them from other organisms? Speaker 1: Um, well I would say it's actually a mix of both. We are also fundamentally interested in the mechanics of it too, right? How, how riboswitch with dysfunction. What is really amazing about Rabis, which is [00:14:00] is that there are so many different species of bacteria that utilize these Ribas switches and these bacteria live in all different types of climates than of them can live in extreme temperatures, both hot and cold and others are more, you know, soil dwelling organisms and live at pretty close to room temperature and all of them have the same sensor. And it's kind of an interesting question to ask how it is that the same sensor works [00:14:30] in all of these organisms? What part of the sequence of the, the switch of the RNA is responsible for for that [inaudible]. Speaker 3: So largely you, you work from the gene DNA area down into the RNA to control the expression of that gene. Speaker 1: Everything that we do does start the DNA level and we have in mind and designed for messenger RNA that we want. And then we can go back and say, okay, [00:15:00] at the DNA level, this is what the DNA instructions have to be to make that messenger RNA. And then we see, okay, let's build it weak. Then express it and see, okay, is the RNA doing? What we want it to and then further on is this messenger RNA being shut off the way that we want it to under this condition and then turned on under a different set of conditions. Speaker 3: And how do you judge whether or not you've had success? Is it pretty black and white [00:15:30] or is it somewhat gray? Speaker 1: One of the kind of very basic techniques that we use is a very simple assay. So you can imagine if we wanted to see whether under condition a this messenger RNA we designed is not making the protein versus condition B when when it is. So what we ended up using is what we call a reporter gene, a gene that expresses a protein that is fluorescent so that if [00:16:00] you shine light at a certain wavelength, you get a light emission from this protein. So we express the gene and in this case on the surface of the plant leaf and we can scan the leaf and let's say condition a is on the left hand side and condition B is on the right hand side. And we'll actually see that the right hand side, the leaf will be glowing and the left hand side of leaf not be glowing because of Ganar that we use to tact [00:16:30] the light emission from the surface of the leaf. Uh, it actually shows up as a gray scale limit. So that's how it turns out. Speaker 3: The organisms that you're currently working with, how do you select them? Speaker 1: One of the ways that you would want to select an organism is, is that other people have worked with the organism and that it's been shown by other researchers that it's easy to do the experiments that you're planning and that there are protocols developed for the experiments [00:17:00] that you're planning. And so it's kind of expedient, but we pick a plant called Nicole [inaudible], Tami Ana that is actually cousin to the tobacco plant, which is of some agricultural interests and also has been shown by other people to be very easy to work with for our experiments. Speaker 3: How has the hardware and the software that you use to do your research changed over the past? What 10 years that you've been doing this [inaudible] Speaker 1: [00:17:30] so we don't actually use much software. We can talk about the hardware. Sure we can like the development of technology to do DNA sequencing very, very rapidly has really been astonishing to see. And for my research in the RNA field, it has an equal impact I would say as well because it turns out if you want to study an RNA sequence, one of the ways we study it is that we do what's called a [00:18:00] reverse transcription. So we convert the RNA back to DNA and then we sequence the DNA that's made from the RNA. So it's kind of the reverse of the normal case of things that technology has enabled people to not just look at the human genome, but what we called a human transcriptome. So this is what are all the Messenger RNHS that are being expressed in different tissue types. And so that has led us to discovering, for [00:18:30] example, these differences in expression at different, um, messenger RNA is on a much, much grander scale. It much, much higher throughput scale than was possible 10 15 years ago. More fundamentally, it has made certain experiments that were impossible to do possible. Now the next challenge is how to sort through all that data Speaker 6: [inaudible]Speaker 5: you are tuned to k a l [00:19:00] x Berkeley. You're listening to spectrum. We're talking with Assistant Professor Mang Hammond about RNA based gene regulation Speaker 6: [inaudible].Speaker 1: Can you explain the a youth stem.org website and I believe you started this, didn't right. So my lab and I started this website called youth stem.org and the inspiration for the website is, it's actually kind of a personal story, [00:19:30] but I think it resonates with a lot of young scientists and other scientists is when I was a younger student, even before I went off to college and I was deciding what subjects I liked, what I like to do, I had these opportunities where yes, some of my science teachers saw something in me or thought that I would enjoy science and wanted to encourage me in the sciences and they would suggest that I go and do some of these programs that [00:20:00] are available in the state of Maryland, for example, where my family is from. And you know, I had a chance to work in a lab at the University of Maryland School of Pharmacy. Speaker 1: And I remember that made a really big impression on me when I was a freshman in college. And my freshman advisor asked me what I wanted to do for work study. I said that, well of course I wanted to do research in a lab because I said why I was already in a lab and in high school and I really liked it [00:20:30] and that's what I want to do for work study. And it was really exciting and really fun. So that's the origin story I guess of you stem. And in fact we have a lot of programs on the Berkeley campus for students interested in science that are, and that some of which pay actually a stipend. And not everyone can afford to pay money to do a summer program, but we have these free programs [00:21:00] that are I think really great. So I wanted to have a mechanism to point that out to local area students. Speaker 1: And the kind of idea I had was, well wouldn't it be great if we had like essentially a craigslist for bay area free local science and engineering and math programs? And so that's um, basically what we intend for a stem to be. [00:21:30] You can actually go on the website. It's you stem.org and you can click on a subject. You know, my favorite subject of course is chemistry. And so you could pick chemistry and it'll actually show you just the programs that are for students interested in chemistry. You can search by your grade and it tell you which programs are for you or you also filter by the location. So we're focused a lot on the East Bay, but there are also programs down in the South Bay down [00:22:00] in San Jose, Santa Cruz that we found in ones up in Monterrey. Speaker 3: So for people locally within the bay area who do have programs, they could contact you through the web. Speaker 1: Right? There's actually a link on the bottoms saying you're saying if you're a program director and you would like to list your program, the criteria is that we're interested in listing programs where the students can apply themselves or it can be nominated by a teacher that it's open to [00:22:30] any student that wants to apply. And uh, certainly we emphasize programs that are free or that pass state band. Speaker 3: And you recently received the NIH director's new innovator award. How did that happen? Speaker 1: Well, the short answer is I applied but um, yes. So it's, it's a really great honor to have received it and actually [00:23:00] to a members of the chemistry department received the new innovator where I this year, myself and Michelle Chang, another assistant professor in the same department. And so it, that was just really great news for both of us. And yeah, it was really a day for celebration in the lab for sure. I mean Hammon thanks very much for coming on spectrum. Thank you. It's a pleasure to be here. Thanks for having me. Brad. Speaker 6: [inaudible]Speaker 3: [00:23:30] irregular feature of spectrum is to mention a few of the science and technology events happening locally over the next few weeks. Rick Kaneski joins me for the calendar. Speaker 7: Come to nerd night [00:24:00] on Wednesday, January 18th at the rickshaw stop, one 55 [inaudible] street at Venice in San Francisco, doors at seven 30 show at eight. All ages are welcome to this $8 show at this month and our night copies of the inaugural issue of nerd night magazine will be given away. There's an article in there about cephalopod sex by the bay area's own. Rich Ross, Robyn, sue Fisher and Corey bloom will share their stories of liquid nitrogen ice cream. Their company smitten in San Francisco's first [00:24:30] made to order scoop shop and they will show off the engineering marvel that is dubbed to Kelvin that can churn up ice cream in under a minute. What do you love? Bounty and David Gallagher. We'll present Carville by the sea. San Francisco's Streetcar, suburb, and you CSF, Phd Student Tsai. Dear Etsy, we'll talk about antibody engineering and how artificially created antibodies can or will eventually fight disease. Visit s F. Dot. [inaudible] dot com for more information, Speaker 3: smoke [00:25:00] and mirrors is geoengineering a solution to global warming. Professor Alan Robock from the Department of Environmental Sciences at Rutgers University will address this question. Wednesday, January 25th 4:00 PM in Barrels Hall Room One 10 on the UC Berkeley campus. This event is free and open to the public Speaker 7: on Thursday, January 26th from seven to 9:00 PM the bone room at 1573 Solano avenue in Berkeley or present [00:25:30] eye to compound eye, the art and science of insect photography. In this free lecture insect photographer Becky Jaffe will incorporate and it dotes from biology, ecology and cultural anthropology to offer an engaging account of her field experiences that will inspire you to pick up the camera and look at insects with new eyes. Visit www.boneroompresents.com for more information now a few news items. Here's the Rick science [00:26:00] news reviews. A January 5th article in science by Sandra Garrett and Joshua Rosenthal at the University of Puerto Rico Medical Sciences campus in San Juan that shows that while octopuses in the Arctic have very similar DNA with warm water octopuses, their nerve cells are very different. This difference allows them to operate in the frigid waters and arises due to m RNA edits. These edits change the way that nerve cells opening includes gates to produce electrical impulses based on the species of octopus. This is the first [00:26:30] discovered example of m RNA editing to help an organism adapt to its environment and speculation remains as to how quickly and prevalent the mechanism might be. Speaker 3: In December, NASA announced seventh 2012 as the new target launch date for the space x commercial orbital transportation services milestone missions two and three. This mission begins with the liftoff of the Falcon nine rocket from Cape Canaveral boosting the Dragon's [00:27:00] spacecraft into low earth orbit. The space x dragon spacecraft will perform all of the commercial orbital transportation services, milestone mission two objectives, which include numerous operations in the vicinity of the International Space Station, and thereafter we'll perform the commercial orbital transportation services milestone mission three objectives. These include approach birthing with the International Space Station, astronauts opening the dragon spacecraft [00:27:30] and unloading cargo. Finally, the astronauts will close the space craft and send it back to Earth for recovery from the Pacific Ocean off the coast of California. This mission, if successful, will mark a major milestone in commercial American space flight Speaker 7: did January 4th issue of the Journal of neuroscience has an article by UCLA is Jenn Lang and others that reports promising anti-alcohol effects of a seed extract from the Asian Havana Dakis or Japanese [00:28:00] raising tree. This was first claimed to be a hangover remedy in the year six five nine rats that took dihydro, Myostatin or [inaudible] were found to take longer to become intoxicated and recovered four times more quickly than rats who did not take the extract. The extract further decrease the likelihood of hangover, anxiety and seizures in the rats. DSM also curved alcohol consumption. Rats consumed more and more alcohol gradually when it allowed, but d h m leased alcohol does not lead to this increased [00:28:30] consumption. DHM blocks alcohol's effects on Gaba receptors and the team has found no side effects in animal testing. They old next study the health effects on people Speaker 2: [inaudible]Speaker 4: the music heard during the show is from a low stone, a David album titled Folk and Acoustic released under a creative Commons attribution license 3.0 Speaker 2: [00:29:00] [inaudible] Speaker 4: production assistance from Rick Karnofsky Speaker 2: [inaudible].Speaker 4: Thank you for listening to spectrum. We are happy to hear from listeners. If you have comments about the show, please send them to us via email. [00:29:30] Our email address is spectrum dot k l x@yahoo.com join us in two weeks at the same time. [inaudible]. Hosted on Acast. See acast.com/privacy for more information.