POPULARITY
5 episodes with Myostatin
2 episodes with Myostatin
4 episodes with Myostatin
2 episodes with Myostatin
2 episodes with Myostatin
2 episodes with Myostatin
We have a new protein drink! Zero Fat, Zero Sugar, Zero Carb…just 23g of superior protein. Get it your protein up now-https://www.geniusshot.com/rp We only back what we use—VersaGrips are a game changer. https://www.versagripps.com/pages/drmike Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. 0:17 Arnold joins the pod 2:50 Recap 5:24 Myostatin drugs 10:17 Age reversal therapy 20:23 Age reversal in older women 23:51 What happens when diseases are gone 34:44 Genetic engineering 42:36 Implications 50:30 The end of weight training 57:15 VR and no more biological humans 1:02:07 Your gains will get boosted
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Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Mark Bell is a world record-breaking powerlifter & host of the Mark Bell Power Project podcast. SPONSORS https://americanfinancing.net/jones - Use the link or call 888-995-2440 today. https://cash.app - Download Cash App today & use code DANNY10 https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off EPISODE LINKS https://youtube.com/@marksmellybell https://youtube.com/@MarkBellsPowerProject https://mindbullet.com https://markbellslingshot.com FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny OUTLINE 00:00 - Kratom 10:37 - Performance enhancing drugs 22:07 - Why the carnivore diet fails 31:10 - Risks of testosterone 43:21 - Adderall as a performance enhancer 47:32 - Alcohol 53:27 - Stop using barbells 01:06:28 - How to strengthen your feet 01:20:13 - Neck strengthening & rope flow 01:30:12 - Sam Sulek 01:41:34 - explanatory knowledge 01:50:23 - Sunlight, circadian rhythm & sleep health 01:56:37 - When to eat your meals 02:04:31 - Fixing a poor light diet 02:08:30 - Best time to exercise 02:10:27 - Myostatin inhibitors 02:20:17 - Trophy kids 02:25:58 - God & the human purpose 02:35:48 - Danny's diet Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dr. Grant Tinsley joins the discussion as the body composition expert.Myostatin is a key regulator of muscle growth.Wendy Whippete the most jacked muscled up dogThe concern of GLP-1 receptor agonists and muscle mass loss.Overview of Courage trial looking at semaglutide and trevogrumab and lean mass lossUpcoming Believe trial coming out (bimagrumab and semaglutide)Exercise remains crucial for muscle health and function.MRI data from SURPASS MRI provides new insights into muscle volume changes.The combination of medications may have varying effects on muscle mass.Caution is advised regarding the long-term effects of new drugs.Clinical benefits of medications often outweigh concerns about muscle loss.Future research will explore the synergy between exercise and medication.Other docs who lift podcasts with Dr. Grant:Tirzepatide muscle lossLean mass loss and GLP-1 meds
We have a new protein drink! Zero Fat, Zero Sugar, Zero Carb…just 23g of superior protein. Get it your protein up now-https://www.geniusshot.com/rp We only back what we use—VersaGrips are a game changer. https://www.versagripps.com/pages/drmike Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. 0:50 Nick's daughter has a dance 1:59 Dr. Mike at da club 3:50 Last week recap 6:07 New drugs 7:15 Weight loss drugs 20:59 How many people are on GLP1s 25:32 Some people can't grow muscle 28:45 Myostatin drugs 45:11 Higher protein needs 46:58 Low energy problems 51:50 Drugs that mime exercise
Der Feind in meinem Fett: Zuviel weißes und vor allem viszerales Körperfett tun uns nicht gut. Vor dem Fettabbau steht die Fettmessung: hier die Folge zu Caliper-Zange, Bioimpedanz, DEXA-Scan und anderen Methoden zur Messung der Körperzusammensetzung. Zum Nachhören: die Folge, in der Genetik-Experte Dr. Stefan Wöhrer den pharmakogenetischen Test von Andreas ausgewertet hat – mit extrem überraschenden Ergebnissen. Spezielle Rabatte für Gen-Tests gibt es für Hörerinnen und Hörer der Biohacking Praxis hier. Eine sehr preisgünstige Caliperzange zum Herumspielen gibt es hier. Eine aufwändigere Caliperzange (inklusive Körper-Maßband) gibt es hier. Bioimpedanz-Waagen sind tatsächlich in der Regel – wie in der Folge erklärt wurde – zwar nicht absolut zuverlässig, aber relativ. Für zuhause sind sie eine vernünftige Möglichkeit, Entwicklungen zu verfolgen. Hier und hier gibt es zwei Modelle mit guten Bewertungen. Es gibt in nahezu allen größeren Städten im DACH-Raum Einrichtungen, die DEXA-Scans anbieten, am besten googlen. Weil er angesprochen wurde: Der „belgian blue“ oder „weißblaue Belgier“ ist der Bodybuilder unter den Rinderrassen. Die blauen Belgier verdanken ihren enormen Muskelanteil einer genetischen Mutation im Myostatin-Gen. Dieses Gen reguliert normalerweise das Muskelwachstum, und durch die Mutation wird seine Funktion gehemmt, was zu einem übermäßigen Muskelwachstum führt. Bilder gibt es im Internet zuhauf. Warum das für Menschen relevant ist? Bryan Johnson unterzog sich 2024 einer Follistatin-Gentherapie. Sie beeinflusst das Myostatin-System. Durch die Erhöhung von Follistatin wird die hemmende Wirkung von Myostatin auf das Muskelwachstum reduziert, was zu einer Zunahme der Muskelmasse führt. Diese Behandlung ist aber äußerst experimentell, Johnson ist mit den Ergebnissen sehr happy, wie er in seiner Netflix-Doku erklärt. (Übrigens wirklich eine tolle Doku.)
In today's episode, we're diving into Follistatin 344. Whether you're interested in performance enhancement, muscle growth, or just curious about the science behind peptide therapies, this episode is for you. What is Follistatin 344? Let's start with the basics – what exactly is Follistatin 344? Follistatin 344 is a naturally occurring protein in the human body, specifically a variant of the follistatin protein. Follistatin itself plays a crucial role in regulating various biological processes, most notably muscle growth and the regulation of myostatin, which is a negative regulator of muscle development. Follistatin 344 is a synthetic form of this protein and is often used in peptide therapy for its muscle-building properties. Is Follistatin 344 a peptide? You would be right to point out that the typical definition of a peptide is a chain of amino acids that is usually 50 amino acids or fewer. By this standard, Follistatin 344 technically exceeds the usual peptide range, as it is a protein fragment consisting of 344 amino acids. This is much larger than what would typically be classified as a peptide. Follistatin 344 is still often referred to as a "peptide" in certain contexts, especially within the realm of peptide therapy and bodybuilding communities. This is because it's a synthetic fragment of a larger protein (follistatin), and it operates in a manner similar to smaller peptides that influence biological processes like muscle growth. So, while it's not a "peptide" by the strictest definition, in many practical uses, it is referred to as such due to its role in peptide therapy and its functional characteristics similar to smaller peptides. How Does Follistatin 344 Work? Now, let's talk about how Follistatin 344 works within the body. Myostatin is a negative regulator of muscle growth. It essentially acts as a ‘brake' on muscle tissue, limiting how much muscle you can build. In individuals with high myostatin levels, muscle growth is naturally suppressed. This is where Follistatin 344 comes in. Follistatin 344 binds to myostatin and prevents it from exerting its inhibitory effects on muscle development. This leads to increased muscle mass, strength, and performance. The action of Follistatin 344 is similar to lifting the restrictions on muscle growth, essentially removing the natural “limiters” that might otherwise hinder progress. Potential Benefits of Follistatin 344 So, why might someone be interested in using Follistatin 344? What are the potential benefits? Increased Muscle Mass: By inhibiting myostatin, Follistatin 344 promotes muscle growth. This makes it popular among bodybuilders and athletes who are looking to increase lean muscle mass without the use of traditional anabolic steroids. Improved Muscle Strength and Performance: Along with muscle mass, strength can also improve as muscle tissue is allowed to grow more effectively. This can translate into better performance in sports and physical activities. Faster Recovery: Some users report faster recovery times from intense workouts or injuries. This could be due to the increased muscle repair and regeneration that Follistatin 344 promotes. Fat Loss: Follistatin 344 may also indirectly support fat loss. As muscle mass increases, the body's metabolism tends to accelerate, which could lead to more efficient fat burning. Potential for Anti-Aging Benefits: There's ongoing research into the potential for Follistatin 344 to slow age-related muscle loss. As we age, we naturally lose muscle mass and strength, so this peptide could potentially help mitigate these effects. Potential Side Effects and Warnings While Follistatin 344 has promising benefits, like any therapy, it's important to be aware of potential side effects and warnings. Unknown Long-Term Effects: As with many peptide therapies, the long-term effects of using Follistatin 344 are not yet fully understood. Most research has been done in animal models, and human studies are still relatively limited. As a result, the long-term safety profile remains unclear. Muscle Imbalance: Because Follistatin 344 inhibits myostatin, there's the possibility of muscle imbalances. Overuse of this peptide could lead to muscle growth in certain areas of the body, while other muscles may not develop as effectively. This could result in a distorted appearance or even strain on the body's natural systems, including the cardiovascular system. Potential Impact on Other Growth Factors: Follistatin also regulates other growth factors in the body. There could be unintended effects on areas like bone growth, fat distribution, and organ function. More research is needed to understand these potential risks. Hormonal Disruption: Peptides like Follistatin 344 interact with various hormonal pathways in the body, so improper use could potentially lead to hormonal imbalances. It's important to approach peptide therapy with caution and consult with a healthcare professional before starting any new regimen. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. If you're ready to dive deeper into the world of nutrition, don't miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It's packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it's always free! So grab your copy today and start your journey to a healthier, smarter way of eating!
This episode explores the critical connections between Vitamin D, muscle health, and energy metabolism, emphasizing its role in muscle protein synthesis, hypertrophy, and body composition. We discuss the latest research, clinical findings, and the importance of maintaining adequate Vitamin D levels for optimal skeletal muscle function.• Understanding Vitamin D's unique secosteroid structure• Role of Vitamin D in muscle function and regeneration• Impact of Vitamin D deficiency on muscle strength across all ages• Energy allocation: Vitamin D's role in shifting calories to muscles• Myostatin inhibition and its influence on muscle growth• Leptin's role in energy management and Vitamin D's effects on it• Clinical trials: Vitamin D supplementation for athletes and older adults• Importance of monitoring Vitamin D levels, especially in winter• Target populations for Vitamin D benefits, including athletes and older adultshttps://pubmed.ncbi.nlm.nih.gov/38766160/https://link.springer.com/article/10.1007/s11033-022-07998-7https://pmc.ncbi.nlm.nih.gov/articles/PMC6021354/Support the show
Are you struggling to build quality muscle? In this encore episode of the “Peak Physique Podcast,” host, and IFBB Professional Bodybuilder, Andre Adams, breaks down the effects of Myostatin as it relates to skeletal muscle and hypertrophy. Find out the role of myostatin protein, how it governs muscle mass, and how to leverage inhibition of myostatin to increase your muscle building capacity. All bodybuilders or individuals looking to build muscle will want to tune in for this knowledge drop! If you like what you just consumed, leave us a 5-star review, and share this episode with a friend to help grow our NASM health and wellness community! Introducing NASM One, the membership for trainers and coaches. For just $35/mo, get unlimited access to over 300 continuing education courses, 50% off additional certifications and specializations, EDGE Trainer Pro all-in-one coaching app to grow your business, unlimited exam attempts and select waived fees. Stay on top of your game and ahead of the curve as a fitness professional with NASM One. Click here to learn more. https://bit.ly/3zoMWyV
STRONGER BONES LIFESTYLE: REVERSING THE COURSE OF OSTEOPOROSIS NATURALLY
Welcome back to the Stronger Bones Lifestyle Podcast! In Episode 89, host Debi Robinson dives deep into the world of gut health and yeast overgrowth with functional diagnostic nutrition practitioner Kim Heintz.Kim has been an FDN for over four years, but her own health journey began long before that. Today she shares her personal journey from chronic migraines and various other symptoms to recovery by addressing gut imbalances. She emphasizes the importance of understanding and managing Candida overgrowth—a common yeast found in functional lab tests that can significantly impact overall health.Debi and Kim discuss holistic protocols focusing on sleep, stress management, diet, and movement to improve bone and gut health. Throughout the episode, you'll learn valuable tips on gut health maintenance, including the importance of managing stress, and supporting natural stomach acid production.Tune in for a comprehensive discussion on addressing Candida and yeast overgrowth, its symptoms, and effective strategies to reclaim your health and build stronger, fracture-resistant bones.Key Takeaways:[3:35] What is yeast and Candida?[4:06] Classic symptoms of overgrowth[5:46] Sugar cravings[7:57] Common types of yeast found in bodies[9:42] Why does this matter [16:11] How do you know if you have yeast issues [18:46] Myostatin and medications to treat this[20:26] Diet[22:37] Targeted supplementation[25:23] The timeframe it can take to solve some of these issues[26:32] Antibiotics[28:04] What role does the yeast overgrowth play[29:00] Biofilms[32:31] Stress[34:33] Yeast and oxalates[38:33] Fermented foods[40:48] Kombucha[42:23] Food scanning apps[42:37] Top 3 actionable steps for maintaining gut health[47:32] In summary[48:24] Spit testWhere to find Guest:InstagramWebsiteMemorable Quotes:"When these symptoms start to pop up they're signs from the body indicating that there's some kind of imbalance going on and you want to take a deeper look at things." [4:42] - Kim"The sooner you do something about it the sooner you get things back in balance too." [12:19] - Kim "We're using nature to balance nature.” [30:38] - Debi"This is not about foods with oxalates, this is about having a healthy gut so you can eat the nutrients to build bones and other tissues." [38:20] - Debi "You need to know if you have the problem in the first place." [40:21] - DebiTo learn more about me and to stay connected, click on the links below:Instagram: @debirobinsonwellnessWebsite: DebiRobinson.comLearn more about and join the Healthy Gut Healthy Bones Program
Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/
What if you had access to your own healthy stem cells, but from a version of you 20, 30 or even 60 years earlier? Stem cells that had the potential to fight diseases you're current self is dealing with... or with skin restoration... or hair loss? It sounds like something out of a science fiction movie, but this is a new reality, and it's here! Now! Dr. Frank Dos Santos has joined me on the pod again. For those that didn't see his previous appearances, I would encourage you to go back and watch or listen. Dr. Dos Santos is the Chief Medical Officer at RWJ Barnabas Healthy. Previously, he was the Chief Medical Officer for the US Navy East, where he was responsible for Global DOD healthcare spanning four continents, and prior to that, he was a Navy and Marine Corps Emergency Medical Service Leader. In this episode, we talk about adult stem cell banking. It's right around the corner, and updates will be coming SOON with specific details on how you can help protect your own health and the health of your family in the future with this safe, simple procedure. It's literally just a blood draw!Other topics we dive into in this episode include:- Myostatin and muscle growth- Exosomes for hair growth- Bioidentical hormone therapy- The effects of protein powders on liver function- And more!Follow Dr. Bob Hariri on his platforms here:Web: www.pilotinghealth.comInstagram: https://www.instagram.com/drbobhariri/X: https://twitter.com/DrBobHaririTikTok: https://www.tiktok.com/@pilotinghealthLinkedIn: https://www.linkedin.com/in/drbobhariri/
Are you struggling to build quality muscle? In this episode of the “Peak Physique Podcast,” host, and IFBB Professional Bodybuilder, Andre Adams, breaks down the effects of Myostatin as it relates to skeletal muscle and hypertrophy. Find out the role of myostatin protein, how it governs muscle mass, and how to leverage inhibition of myostatin to increase your muscle building capacity. All bodybuilders or individuals looking to build muscle will want to tune in for this knowledge drop! If you like what you just consumed, leave us a 5-star review, and share this episode with a friend to help grow our NASM health and wellness community! Did you hear? The most trusted name in fitness is now the most trusted name in sports performance nutrition. Become an NASM Certified Sports Nutrition Coach and optimize performance and recovery. https://bit.ly/3xdfA55
Watch Here : https://www.youtube.com/watch?v=nALG4Xqjvrk Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve
Dr Glenn McConell chats with Associate Professor Chris Fry from the University of Kentucky, USA. Joint injury causes muscle weakness and atrophy (reductions in muscle size) due to the the inactivity but also separately due to the injury itself. Substances are released from muscle to help repair the joint/bone. Prehab is important before surgery. There can be residual effects long after joint injury. We also discussed hypertrophy and aging and the importance of having a lot of muscle capillaries as age to obtain the optimum response to resistance training. Lots more. We had a really great chat. Chris has a very pleasant manner. I enjoyed it a lot. Twitter: @ChrisFryPhD0:00. Introduction and welcome3:09. How Chris got into exercise research6:10. ACL injuries and muscle wasting /weakness9:05. Joint injuries and the risk of arthritis10:05. The effects of the inactivity vs the injury itself13:55. Protein synthesis vs breakdown after an ACL injury19:30. Why in evolutionary sense does joint injury result in muscle atrophy22:50. What are the signals to cause muscle atrophy24:00. Myostatin release after joint injury26:55. Acute vs chronic injury28:15. Other joint injuries to joints (other than ACL)29:25. Atrophy in different muscle fibre types31:15. Best way to prepare for surgery after an injury34:05. How quickly start rehab after surgery35:45. Are there residual effects long after joint injury?39:55. Bone vs joint injury43:30. Muscle reactive oxygen species/ mitochondria after injury46:05. Aerobic capacity of muscle still reduced after rehab47:05. Should take anti inflammatories after injury?49:20. Vitamin D and muscle injury52:15. Does joint injury affect muscle in the non injuried limb?54:45. What can do to slow atrophy after injury?55:55. Does muscle size and strength go hand in hand after injury57:15. Time since injury/trauma and surgery58:55. Sex difference and joint injury1:00:20. Age and joint injuries1:01:10. Hypertrophy and aging1:02:05. Aging: inactivity vs training response1:03:00. More capillaries in muscle increases response to resistance training1:05:00. Aerobic pre conditioning can help with hypertrophy1:08:30. Anabolic resistance and aging1:12:25. Connective tissue and training responses with aging1:15:20. Satellite cells and muscle growth1:17:45. Takeaway messages1:19:01. Outro Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: glenn.mcconell@gmail.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice
Jerry Brainum, former writer for Flex, Muscle & Fitness and IronMan Magazine, is the guest on this episode of the Bodybuilding Legends Podcast to review the year 1993 in Bodybuilding. In Part Two of their interview, Jerry and host John Hansen talk about some of the major professional bodybuilding competitions in 1993 including the IronMan Pro Invitational, the Arnold Classic won by Flex Wheeler, the Night of the Champions won by Porter Cottrell and some other IFBB Grand Prix events. At the end of the podcast, John reads an article written by Kal Szkalak for the May/June issue of Muscle Digest magazine regarding the controversial judging of the 1977 IFBB Mr. Universe in which Kal beat Mike Mentzer in the heavyweight class. (Time Stamps below) Time Stamps: 5:20 - RIP Carl Weathers 6:13 - Start of interview with Jerry Brainum 6:40 - Flex Wheeler's pro debut 11:10 - Myostatin gene 15:40 - New bodybuilding talent in the 90's 20:17 - Growth hormone and insulin 23:45 - Women competitors and drugs 27:05 - 1993 Pro IronMan Invitational 42:25 - Mike Matarazzo's dangerous condition 48:45 - Grand Prix contests after the Arnold 50:53 - Porter Cottrell sweeps the spring shows 59:40 - Porter vs Munzer at the 1993 Night of the Champions 1:06:00 - Low body fat percentages and muscle loss 1:19:15 - WBF Bodybuilders return to the IFBB 1:32:00 - John reads the article "What Happened to Simple Honesty?" written by Kal Szkalak for the May/June 1978 issue of Muscle Digest magazine. Links: Jerry's Applied Metabolics newsletter Become a Patreon Sponsor Bodybuilding Legends website John's YouTube Channel John's Online Coaching Programs
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The Future of Health: AI and Gene Therapy's Role in Extending Lifespanhttps://youtu.be/XQy5Ov69HWcDiscover the groundbreaking intersection of biotechnology and artificial intelligence in 'Revolutionizing Aging,' a deep dive into the latest innovations in longevity gene therapy. Join us as we explore how cutting-edge genetic interventions like TERT, Klotho, and Myostatin, combined with AI's analytical power, are paving the way for a future where aging is no longer an inevitable decline but a modifiable aspect of human biology.KeywordsLongevity Gene TherapyAI in HealthcareAnti-Aging Genetic InterventionsTERT ActivationKlotho ProteinMyostatin InhibitionBioviva InnovationsLibella Gene Therapy ResearchPersonalized MedicineEthical Implications of Gene EditingFuture of Regenerative MedicineSubscribe for weekly updates and deep dives into artificial intelligence innovations.✅ Don't forget to Like, Comment, and Share this video to support our content.
On this episode we were joined by special guest Dr. Chris Fry from the University of Kentucky. GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury Brightwell CR, Latham CM, Keeble AR, et al. Sci Adv. 2023;9(48):eadi9134. doi:10.1126/sciadv.adi9134 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight
Watch Here : https://www.youtube.com/watch?v=baceuJcMH0k Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve
Watch Here : https://www.youtube.com/watch?v=tterjb55Jrc Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve
Watch Here : https://www.youtube.com/watch?v=rSF3ZyEy5zQ Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve
Can Tren change your DNA? YK11 & Myostatin, Worst Cycles and do we get desensitized to androgens with age? TIME STAMPS BELOW - DNS Podcast 197 Dave Crosland & Scott McNally
I talk about the first part of this interesting book. It's got interesting facts, research studies, and stories.
Your hosts Stevesmi and Da Mobster discuss Peptides in this iTunes podcast with this one being ACE-031 doses, cycles, benefits and its side effects • Ace-031 what is it and what does it do • What would its clinical use be • How would it be used by bodybuilders and strength athletes • What kind of side effects might we see? • What is Myostatin and what is its role? • Just how expensive would a cycle be? • Dosing protocols Link to article: https://www.evolutionary.org/ace-031-myostatin-inhibitor Links to Evo threads: 1. https://www.evolutionary.org/forums/supplements/ace-031-a-37759.html 2. https://www.evolutionary.org/forums/anabolic-steroids-peds/ace-031-clinical-trials-where-buy-ace-031-a-20387.html 3. https://www.evolutionary.org/forums/anabolic-steroids-peds/ace-031-discussed-39033.html 4. https://www.evolutionary.org/forums/anabolic-steroids-peds/follistatin-344-ace-031-almost-here!!-20292.html 5. https://www.evolutionary.org/forums/anabolic-steroids-peds/ace-031-peptide-info-79665.html For 1-on-1 coaching/consultation/source help requests hit up Stevesmi https://www.elitefitness.com/forum/members/stevesmi.html https://www.evolutionary.org/forums/members/stevesmi.html Where to get blood tests: https://www.evolutionary.org/forums/source-talk/bloodwork-private-md-5695.html Please note we're not doctors and the opinions are ours. It's our view and is based on our experience and views on the topic. Our Podcasts are for informational purposes and entertainment only. The Freedom of speech and 1st amendment applies.
Beim Muskelwachstum geht es nicht nur um Proteine, sondern vor allem um das richtige Training. Und dafür haben wir uns einen großartigen Gast eingeladen, der das Ganze von der wissenschaftlichen Seite aus betrachtet. Viel Spaß! 02:09 Fitnesswissenschaftskongress 04:02 Fitnesswissenschaften vs. Sportwissenschaften 10:05 YouTube als Wissenschaftler 12:13 Wie bist du selbst zur Forschung gekommen? 13:23 Welche Ergebnisse haben dich bisher am meisten überrascht? 15:04 Myostatin & Muskelwachstum 20:22 Warum habt ihr das Thema Hypertrophie für das Buch gewählt? 23:34 Was hat sich in der Wissenschaft verändert? 25:22 Formen der Hypertrophie 29:15 Wie wird Hypertrophie im Körper ausgelöst? 31:48 Wie erreicht man maximale Hypertrophie? 36:57 Welche Rolle spielt die Genetik beim Muskelaufbau? 42:09 Individuelle Trainingsplanung 43:44 Wie viele Sätze pro Woche braucht man? 53:16 Gewinnspiel ---------------------------------------------- Unsere Website: www.trainingohnelimit.de ---------------------------------------------- Hier könnt ihr das Buch "Hypertrophietraining - Wissenschaft und Praxis für optimalen Muskelaufbau" bestellen: https://www.m-vg.de/riva/shop/article/22601-hypertrophietraining/ ---------------------------------------------- Hier findet ihr Stephan: YouTube: https://www.youtube.com/c/fitnessprofessor Instagram: https://www.instagram.com/derfitnessprofessor/ Website: https://www.ist-hochschule.de/dozent/636/geisler ---------------------------------------------- Und vielen Dank an die Kolleg:innen vom Riva Verlag für die tolle Zusammenarbeit! Instagram: https://www.instagram.com/riva_verlag/ ---------------------------------------------- Wenn euch die Folge gefallen hat, dann teilt sie mit euren Freunden. Abonniert uns bei Spotify und Apple Podcast, damit ihr keine Folge verpasst. Wir hören uns wieder am nächsten Montag. Startet gut in die Woche! Instagram TOL: https://www.instagram.com/trainingohnelimit Instagram Silvan: https://www.instagram.com/silvanschlegelpt Instagram Hendrik: https://www.instagram.com/hendrik_senf
Fazla miktarda bulunması halinde kassal gelişimi engelleyen bu proteinin vücuttaki seviyelerini düşürmek mümkün müdür?
Wild Wednesday - Creatine 5g/day keeps crutches away! http://betterdaily.live
Drs. Peter and Takako Jones discuss the ACE-083 trial and the basis of myostatin inhibition for FSHD, and go through the data showing that berberine, despite proof-of-concept studies showing it to be an inhibitor of DUX4 expression, is highly unlikely to be an effective treatment for FSHD. --- Send in a voice message: https://anchor.fm/peter-l-jones/message
In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: Sometimes you can lose weight on the scale and STILL get fatter! (4:25) A study linking more sleep to increased fat loss. (20:54) Adam's supplement stack to stay healthy. (26:36) Mind Pump Recommends, The Tinder Swindler on Netflix. (34:00) Is this the end of Mind Pump on social media? (42:43) The results when Sal takes too many supplements. (46:43) What to expect with your Butcher Box subscription. (50:32) What's the deal with the big toe shoe Reebok?! (52:51) Adam finally doesn't care. (57:13) Sal, welcome to having a nice car. (58:47) #ListenerLive question #1 - Can you share any insight on the myostatin inhibitor, YK11? (1:01:38) #ListenerLive question #2 - Any tips for increasing my appetite if I'm having trouble bulking due to my faster metabolism? (1:12:00) #ListenerLive question #3 - How can I boost my slower metabolism after a massive weight loss? (1:23:10) #ListenerLive question #4 - How can I maintain muscle while training for performance for an upcoming fitness test? (1:33:39) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com February Promotion: MAPS Performance and MAPS Aesthetic 50% off!! **Promo code “FEB50” at checkout** Why The Scale Is Not Always The Best Way To Measure Progress – Mind Pump Blog How Resistance Training Works – Mind Pump Blog Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings Visit LivON Labs for an exclusive offer for Mind Pump listeners! Watch The Tinder Swindler | Netflix Official Site Feds arrest a New York couple and seize $3.6 billion in stolen cryptocurrency Yohimbine Supplement - Examine.com Visit Butcher Box for this month's exclusive Mind Pump offer! The Kith for Birkenstock Collab is a Warm Wave of Shearling and Suede Visit MASSZYMES by biOptimizers for an exclusive offer for Mind Pump listeners! **Promo code “MINDPUMP10” at checkout** YK11 SARM: How It Works, What To Expect & Results Mind Pump Hormones Facebook Private Forum MAPS Fitness Anabolic MAPS Strong Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Ben Pakulski (@bpakfitness) Instagram
DRUGS N STUFF 123 - DAVE CROSLAND & SCOTT MCNALLY - TIME STAMPS BELOW
Hi everyone and welcome back to BFR Radio. Thanks for joining in and hope that your training is going well. Before I head into today's article review, a quick reminder that if you're looking for practical ideas on how to implement BFR into your own training check out my Instagram (@chrisgaviglio) or my Youtube channel which is SportsRehabAus. If you follow me on social media, I've also been trialling a few different things. The first one is 60second snippets of the best bits of the podcast as well as Instagram text image posts – which do you prefer? Also if you're enjoying the podcast, please give it a rating on iTunes. Its also been a while since my last episode and I thank you for your patience. I've had a few presentations recently and one was for the ASCA. This year was an online style conference and my presentation I spoke about how I periodise strength training utilising a myriad of different concepts. In particular it was a case study of one of the decathletes that I coached for the Tokyo Olympics. I've also had a work change as well so navigating that has taken some of my time. One of the positives is that I am spending more time putting together some other S&C and BFR concepts that I've been wanting to do for a while. In particular I am providing an online S&C service which means that if you've been thinking about improving your training, I can help provide this for you. Just contact me through my socials or the contact us on my website. I also have some big plans for BFR specifically so stay tuned for that. The last few episodes was a short series of papers which reviewed different sports specific training with BFR and highlighted potential direct benefits to sports performance. For me it shows that BFR can be used for more than just strength training and stationary cardiovascular-based training. To change it up, it's time for a “Your questions answered” segment. Interestingly I got 3 independent emails on a very similar subject within the last month. In particular it is on the subject of using BFR with youth athletes. Hopefully not too controversial, but I thought I'd tackle this subject. To give some context behind the questions the first question was from a physiotherapist who is involved in the training of elite Artistic gymnasts aged between 10-26. Common injuries include growth-related injuries such as osgoods and, tendinopathy injuries especially the Achilles Tendon as well as boney stress injuries (foot, shin, and back). And in previous podcasts I'd alluded to BFR being a great tool for tendon pain as well as recovering from bone stress injuries and such could BFR be used in this specific population. The second question was from another physiotherapist who works with dancers and in particular young dancers and pretty much similar. They want to know the youngest age I'd use BFR training with? And are there any contraindications for use in those under 18years? So how to best answer this question? Unfortunately there isn't any position statement with respect to BFR and Youth. There is very little out there but I will piece this together to give you a balanced answer and perhaps rather my opinion. No use sense sitting on the fence right?? To answer this question, I am going to break this into 3 parts. Firstly I want to briefly discuss the idea of strength training in youth in general (that is without BFR). Secondly, I will highlight a few studies in younger age groups and then finish up with my own view and personal experiences. I hope you enjoy this one. I feel I have given a balanced view with respect to this concept and before I go I want to emphasis a few points if you decide that BFR may be useful with the youth athletes that you train: Like all training interventions you need to be clear why you are using it. This type of training needs strict supervision, and at this age in particular. At a young age who are fit, healthy and performing general training, I would not prescribe it. I think there are so many other skills and physical activities that you need them to be exploring before worrying about BFR. However if they are have specific injuries or issues that need addressing it may be a useful intervention. The paper's that I briefly mention are: Effects of practical blood flow restriction training on adolescent lower-body strength. (15-18year old girls) Luebbers, P. E., Witte, E. V., Oshel, J. Q., & Butler, M. S. (2019). The Journal of Strength & Conditioning Research, 33(10), 2674-2683. Effect of eight-week aerobic training with blood flow restriction on lipid profiles and body composition in obese adolescent boys. (13-16year old boys) MOHAMMADI, S., Rajabi, H., Motamedi, P., Khaledi, N., & Abdollahi, M. (2019). Response of Myostatin to Resistance Exercise with and without Blood Flow Restriction in Immature Male Athletes. (10-14year old boy gymnasts) Shabkhiz, F., Choobineh, S., Ghafarioun Isfahani, A., & Yari, M. (2017). Sport Physiology & Management Investigations, 9(3), 9-19. A pediatric case with an unstabilized neck treated with skeletal muscle electrical stimulation and KAATSU training®. (2yrs-4months boy ) Iwashita, H. (2015). International Journal of KAATSU Training Research, 11(1), 7-12. The Australian Strength & Conditioning Association (ASCA) position stand on youth strength training link: Resistance Training for Youth - Position Stand I'd love to hear from anyone who's used BFR in these age groups. I think it could be a good extension to this podcast. Contact me through my website (sportsrehab.com.au) or DM me through my Instagram or Twitter @chrisgaviglio. Before I go, A couple of favours from me to you. If you know of someone who would benefit from this episode, please share it. And if you're interested in purchasing your own set of BFR cuffs please visit my website which is www.sportsrehab.com.au I can also help you with your training so contact me via my website or DM me through my socials which is @chrisgaviglio. Thanks for listening and remember to keep the pump.
Show notes: 01:40 WASTE #1: Supplements that DO NOT WORK! (And which ones actually do). 03:27 B.S. “natural testosterone boosters.” 05:00 Myostatin inhibitors for muscle gains—do they work??? 07:17 Laxogenin: plant based anabolic??? 08:59 TRT (testosterone replacement therapy) vs. “natural plant-based testosterone boosters” cost analysis. 09:57 WASTE #2: Your diet is TOO COMPLICATED! 13:03 The Sweet Potato Diet, by Michael Morelli. 8 sweet potato recipes I used up through all my last contest preps including sweet potato birthday cake! 16:18 WASTE #3: Gimmicky protein bars and energy drinks. 20:04 Client highlight: Todd Rogers and how he re-arranged his budget to make prioritize proper nutrition, supplements, and coaching to build muscle and burn fat consecutively for 6 weeks and counting. 21:29 Why you don't need a Calorie surplus to build muscle. 22:46 WASTE #4: Cheap workouts and meal plans. 24:20 WASTE #5: Inconsistency. 27:07 Taylor's big decision to regain her health after two C-sections and how she stuck with it. 29:03 WASTE #6: Unnecessarily over-using the gym. 31:01 Ideas of hypertrophy training that can be done outside the gym. 34:13 WASTE #7: Unnecessary gym equipment. 35:05 FIVE (5) useful tools that are a wise investment as you advance in bodybuilding training. 42:21 SOLUTION #1: Coach a friend! 43:22 SOLUTION #2: Ideas to reduce unnecessary spending. 44:16 SOLUTION #3: Negotiating/trading services with people you do business with. 46:19 SOLUTION #4: Ideas of how to make additional money on the side of your job. 47:15 SOLUTION #5: Optimizing effective supplement and grocery spending. Book your free 15-minute phone consultation with Coach Colt: https://calendly.com/ssyl/meet-greet Dope background music by WALKER MUSIC: https://www.youtube.com/user/ShaunWhiteFan123 To purchase skull cable attachment: https://supersetyourlife.com/products/rope-cable-attachment-extra-long https://supersetyourlife.com/collections/supplements
Dr. Brandon Roberts' background and interestsResearch in the supplement fieldMuscle loss and muscle gainGenetics and muscle gainThoughts on myostatinNSAID research on muscle growth and bone healingFind Brandon on Instagram: @brob_21 or email: robertsb21@gmail.com.
The Thoroughbred is a horse breed best known for its use in racing. Intense selection for speed and stamina has led the Thoroughbred to develop energy-efficient muscles, with a high aerobic capacity relative to skeletal muscle mass. Dr Mary F. Rooney and her colleagues from University College Dublin and Trinity College Dublin, Ireland, investigated how different myostatin genotypes in equine muscle are correlated with muscle fibre composition and, ultimately, influence the race distance aptitude of the Thoroughbred horse.
Myostatin-related muscle hypertrophy is a rare condition characterized by reduced body fat and increased muscle size. Affected individuals have up to twice the usual amount of muscle mass in their bodies. They also tend to have increased muscle strength. This condition is not known to cause any medical problems, and affected individuals are intellectually normal. Myostatin-related muscle hypertrophy is caused by mutations in the MSTN gene. It follows an incomplete autosomal dominant pattern of inheritance. In layman's terms: Too LITTLE Myostatin causes too MUCH muscle. Our guest today is discussing her son's condition where he has twice the normal myostatin in his body, and yet he has more muscle mass and less fat in his body than his peers! It is possible that he is the only living person with this particular disorder, thereby officially kicking off our "Rare-Diseases Segment" of PodcastDX. Shari Graber knew, without a doubt, her son was special the day he was born. From her hospital bed, she saw her infant, only hours old, lift his head from his bassinet in the hospital room and look around the room! "No one would ever believe me" she thought to herself- and Dylan's life began with gusto! Listen to this week's episode to hear this incredible story! (Pictured) Dylan, Mackenzie, Shari & Kevin Graber
Major Erectile Dysfunction from Roids Use in 21 Year Old - The Bodybuilding Podcast Episode 38 ULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING https://bodybuilderinthailand.com/ultimate-guide-to-roids/ Listen to the Bodybuilding Podcast on ITunes and Spotify! 0:00 the foundation of bodybuilding is steroids and human growth hormone 1:55 the synthesis of testosterone and pituitary extract 3:40 Esoteric Steroids Knowledge 5:30 Side Effects of Long Term use of 600mg testosterone per week 10:00 Asking Permission to take a cycle or use gear 12:20 Myostatin and Androgen Receptor down regulation 16:30 New Tren user having post injection pain 19:03 If you are worried about steroids infections and abcess 24:45 High Hematocrit and Hemoglobin from Steroid Use 29:45 Major Erectile Dysfunction from Roids Use in 21 Year Old 31:04 Generic Growth Hormone and Long Term Sexual Dysfunction 36:45 Middle Age Guy looking for a Boost 38:00 Mental and Motivational effects of going on TRT when you have low testosterone levels 41:10 Testosterone Esters Cypionate vs Enanthate 41:40 Can your General Practitioner prescribe you steroids 44:00 Will you fail a drug test from taking steroids 45:20 Guy has a good idea for a killer cycle 47:30 Aromasin Chemistry Explained 49:40 Arnold Schwarzenegger used Human Growth Hormone 52:17 Whey Protein Shakes This Podcast is for entertainment and conversational purposes only. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.
Drugs n Stuff 69: Steroid Esters. This week, Myostatin mice experiments. Then Weekly Topic - Steroid Esters. Plus tons of listener questions. Presented by: TRUE NUTRITION. Code: ADVICES https://www.truenutrition.com/ 3rd Party Tested, Discover the source that bodybuilders trust! Reach out to Dave: Croslands.org.uk Reach out to Scott: mcnallydiets@gmail.com
In this episode, Sal, Adam & Justin discuss how to determine your true muscle building potential and how to get there. Are the guys hitting their true muscle-building potential? (2:47) Why it's important to consider what your potential could be? (8:25) Bodybuilders vs sheer muscle size. (15:30) The two factors that influence your muscle-building potential. (19:06) #1 - Genetics. (19:20) Muscle belly length. (19:52) Bone structure. (23:15) Muscle fiber type. (24:14) Hormones/Metabolism. (28:10) Gigantism. (31:27) Myostatin. (32:06) The central nervous system (CNS). (34:07) #2 - Lifestyle. (38:17) Training. (38:30) Diet. (44:25) Sleep. (48:47) Consistency. (53:56) Stress. (55:11) What should you focus all of your energy on? (56:14) Related Links/Products Mentioned June Promotion: MAPS HIIT ½ off! **Promo code “HIIT50” at checkout** Visit Felix Gray for an exclusive offer for Mind Pump listeners! Muscle Potential Calculator - Mind Pump Media Maximum Muscular Bodyweight and Measurements Calculator by Casey Butt. A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs How Your Genetics Influence Your Muscle Building Potential – Mind Pump Blog The Most Overlooked Muscle Building Principle – Mind Pump Blog MAPS Fitness Products The Other Best Muscle Building Exercises of All Time – Mind Pump Blog How to Manipulate Macros for Building Muscle – Mind Pump Blog Mind Pump Podcast - YouTube Mind Pump Free Resources
en este episodio conocerás consejos de como estructurar el entrenamiento en casa en base a los componentes de la carga más importantes, así como aplicar los principios que te permitan progresar o disminuir el desentrenamiento referencias por si quieres profundizar en el tema: Chen P, Mao L, Nassis G, Harmer P, Ainsworth B, Li F. Coronavirus disease (COVID-19): The need to maintain regular physical activity while taking precautions. Jespersen, J. G., Nedergaard, A., Andersen, L. L., Schjerling, P., & Andersen, J. L. (2011). Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining. Nieman D, Wentz L. The compelling link between physical activity and the body's defense system. mi instagram: https://www.instagram.com/marcosperezmrv/?hl=es-la
Reading about this 9 year old power lifter in Louisiana got me thinking about individuals with a mutated myostatin gene. This rare condition has no negative side effects (that we know of), so it is a very interesting topic that, if it could be manipulated by scientists, could bring about this super-hero-esq human, in theory, of course.
We discuss early trial data that shows SRK-015 increases myostatin growth factor levels up to 100-fold in SMA patients & Forums Director Kevin Schaefer reads an excerpt from Alyssa Silva’s latest column. Are you interested in learning more about the spinal muscular atrophy? Please visit www.smanewstoday.com
We discuss early trial data that shows SRK-015 increases myostatin growth factor levels up to 100-fold in SMA patients & Forums Director Kevin Schaefer reads an excerpt from Alyssa Silva’s latest column. Are you interested in learning more about the spinal muscular atrophy? Please visit www.smanewstoday.com
Myostatin is a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit muscle cell growth and differentiation and boy do we bring it up a bunch. Welcome to another episode of What’s Your Condition, an internet review show where nothing is answered and no one learns anything. Three friends explore a surreal digital world by deconstructing the absurd fringes of the internet's overlooked underbelly as an excuse to spend time together.Twitter - http://twitter.com/urconditionInstagram - https://www.instagram.com/whatsyourconditionYoutube - https://www.youtube.com/channel/UCGf9E_r6rSsIInfjdGa-zoQSound effects and music obtained from www.zapsplat.comFind out more at http://www.whatsyourcondition.comThis podcast is powered by Pinecast.
It’s theorized in the bodybuilding community that the reason Flex Wheeler and other top Olympia caliber bodybuilders are able to build such incredible physiques is due to Myostatin deficiency. Other popular theories circulate around that include ideas as vastly different as androgen receptor sensitivity is higher in top bodybuilders, to the complete opposite side of the spectrum where some believe that training past a certain pain threshold is what separates champions from the rest and that genetics are just a small factor in determining bodybuilding success.…
When I first started getting into bodybuilding and learning about pharmacology, a strategy I would see commonly advised on forums and by industry gurus was switching compounds at week 6 or week 8 to avoid androgen receptor downregulation and circumvent a plateau on a steroid cycle.…
Email us, stories@zeropercentscared.com This week, we try and recover from the bummer of satanic panic with superpowers! Super smellers, folks who are strong AF, bones that never break, perfect memories and mega-athletes to name a few. We also talk about a whole mess of genetics, get excited people. Stuff we talked about: Melissa McCracken: Songs as Paintings Strongman Louis Cyr, real life superman Liam Hoekstra and Myostatin-related muscle hypertrophy Daniel Kish, Bat Man! Wallmeier and Weigrebe "Self-motion facilitates echo-acoustic orientation in humans" 2014 Joy Milne, Woman who can smell Parkinson's Disease Gene Editing on Last Week Tonight Radio Lab, Limits Radio Lab, CRISPR The Myth of Genetic Superbabies Josiah Zayner - biohacker and CRISPR experimenter Kim Peek, the Human Microfiche! Veronica Seider, Eagle Eyes!
Do Androgen Receptors Downregulate? There is a very common misconception in the bodybuilding community that androgen receptors downregulate during a steroid cycle, or during long-term steroid use. A plateau in muscle gain is commonly attributed to this “androgen receptor downregulation”. If you've ever cycled anabolics, you can also attest to the fact that during a new cycle the gains always seem to come within the first 8 weeks or so, and then the weeks following that it is typical to notice a blatant diminishing returns effect.…
In this episode I talk about the SARM YK11.
A new year means New Year’s resolutions and a new episode of Tangents! Lots of people are probably getting their fitness on, whether it’s by joining a gym or putting on yoga YouTube videos. So this week, we’re stretching our muscles to explore the science of exercise. If you just wiggle your arm a bunch, does that technically count as exercise? Are beefy babies real or just photoshopped? And what happens if you leave a hamster wheel in the middle of a forest? If you want to learn more about any of our main topics, check out these links: [Truth or Fail] Myostatin-related muscle hypertrophy: https://www.ncbi.nlm.nih.gov/books/NBK1498/ Increased blood volume: https://www.ncbi.nlm.nih.gov/pubmed/17630597/ New brain cells: https://www.eurekalert.org/pub_releases/2017-11/nwsu-eib111217.php [Fact Off] Thinking about muscles: https://www.physiology.org/doi/full/10.1152/jn.00386.2014 https://www.scientificamerican.com/article/how-to-grow-stronger-without-lifting-weights/ Animals on wheels: http://rspb.royalsocietypublishing.org/content/281/1786/20140210.full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760155/ https://www.biorxiv.org/content/biorxiv/early/2018/09/14/409409.full.pdf [Ask the Science Couch] Flexibility: http://web.mit.edu/tkd/stretch/stretching_2.html http://web.mit.edu/tkd/stretch/stretching_3.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273886/ [Butt One More Thing] Space underwear: https://www.reuters.com/article/us-space-underwear-idUSTRE52M6ER20090323
Muscle Expert Podcast | Ben Pakulski Interviews | How to Build Muscle & Dominate Life
On the podcast today is one of the most knowledgeable human beings on the planet in the field of performance-enhancing substances, SARMs (specific androgen receptor modulators), and bio-regulatory and repairing peptides. Full Show Notes Here: http://www.benpakulski.com/podcasts/jeanfrancois/ Our guest, Jean Francois Tremblay from UQAM (Université du Québec à Montréal) talks with Ben about the use of peptides, SARMS, Myostatin inhibitors and their practical applications in sports performance, anti-aging and health in general. Connect On Facebook Connect on Instagram @themuscleexperts About Jean Francois Tremblay Jean-François Tremblay studied Exercise Physiology, Biochemistry and Pharmacy. He is now, a student and researcher at UQAM. He has been researching (in theory and in practice) peptides and sarms since the 90s and will soon be making it his main research subject in the coming months. He will present a theoretical basis on what they are and their practical applications in sports performance, anti-aging and health in general." Key Highlights ⇾ Is there a case for taking low doses of IGF -1 and growth hormone to improve longevity? ⇾ How to dose myostatin inhibitors? Which ones are the most effective? What are the potential negative side effects? ⇾ The "timeless peptides" for life extension. Time Stamps: 4:10 - What is a peptide? 6:14 - Synthesizing peptides. 10:49 - Myostatin inhibitors and the negative side effects. 14:54 - How to dose myostatin inhibitors. 17:34 - Increasing growth hormone with peptides. 23:04 - How should you take growth hormone, specific protocols for athletes. 26:34 - IGF -1 and growth hormone for longevity? 29:34 - Genetics, and responsiveness to PED’s. 33:54 - Peptides for fat loss. 37:52 - BPC - Body protective compounds, healing the GI. 41:04 - Peptides discovered in Russia. Bioregulators. 45:57 - Timeless peptides for life extension. 46:51 - The next step for elite athletes. 53:04 - Biggest misconceptions about specific peptides. 58:24 - How SARMS work. RAD -140 1:11:34 - Spiking growth hormone during sleep. Connect with Jean Francois Facebook Connect With Ben Facebook Twitter Instagram Sponsors This podcast is brought to you by Prime Fitness USA, bringing you the most innovative strength training equipment using their patented SmartStrength technology. This podcast is brought to you by ATP Lab! For cutting-edge supplementation with a purpose, check out ATP Labs. This podcast is made possible by Gasp! Top notch quality training wear, Muscle Expert approved training gear! Get 10% off when you use the discount code BEN10 at checkout at Gasp Online Today!
This episode is a roundtable discussion with Tommy Wood, MD, PhD and New York Times best-selling author Robb Wolf on Robb’s new Keto Masterclass, a 45-day program to kickstart your keto lifestyle. The masterclass is an online training course that I completed ahead of recording this episode. Think of the class as a comprehensive instruction manual complete with troubleshooting guide for fat loss and improved metabolic health. If you’re brand new, the course is perfect for you. If you’ve been living the lifestyle for some time, it may still be helpful to read the manual to see if there’s anything you’ve missed. Here’s the outline of this interview with Robb Wolf and Dr Tommy Wood: [00:01:15] Ken Ford on STEM-Talk. [00:01:33] Books: The Paleo Solution: The Original Human Diet, Wired to Eat: Turn Off Cravings, Rewire Your Appetite for Weight Loss, and Determine the Foods That Work for You. [00:03:34] CrossFit. [00:05:28] Ryan Levesque, Ask Method. [00:07:30] Blog: Optimizing Cycling Stage Race Performance using Nutritional Ketosis by Sami Inkinen. [00:10:05] The course is for the Weight Watchers crowd. [00:12:50] Facebook Video: Paleo vs keto video with Robb and Nicki. [00:14:42] The NBT 7-minute analysis. [00:16:10] Facebook Group: Richard Nikoley's Ketotard Chronicles. [00:17:00] Mike Rowe and Dirty Jobs. [00:19:28] When are you fixed? [00:20:10] Book: Diabetes Epidemic & You by Joseph R. Kraft to learn about the Kraft test (5 hour GTT), Lipoprotein Insulin Resistance Index (LP-IR): A Lipoprotein Particle–Derived Measure of Insulin Resistance. [00:20:34] 7-day carb test. [00:20:59] Eating while the sun is up. [00:22:16] Full carnivore, ketotic.org guys. [00:22:59] The Keto Summit. [00:23:33] Ketogains. [00:23:48] Electrolytes. [00:24:47] Calories and food quality matter. [00:25:55] Thyroid and adrenal issues. [00:27:01] Undereating. [00:28:09] Doc Parsley’s Sleep Remedy. [00:28:27] Blog: Virta Health: Does Your Thyroid Need Dietary Carbohydrates? By Stephen Phinney, MD, PhD. [00:28:58] Managing symptoms. [00:30:11] Warren Buffett. [00:30:48] Stephen Phinney, MD, PhD. [00:31:46] Loren Cordain, PhD on sodium. [00:33:38] Jeff Volek, PhD, RD. [00:33:53] Book: The Salt Fix: Why the Experts Got It All Wrong--and How Eating More Might Save Your Life by James DiNicolantonio. [00:34:56] Sodium, potassium, magnesium, calcium (be careful). [00:36:22] Studies: DeFronzo, R. A. "The effect of insulin on renal sodium metabolism." Diabetologia 21.3 (1981): 165-171 and Brands, Michael W., and M. Marlina Manhiani. "Sodium-retaining effect of insulin in diabetes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 303.11 (2012): R1101-R1109. [00:37:35] Presentation: Oxidative Stress & Carbohydrate Intolerance: An Ancestral Perspective by Chris Masterjohn, PhD. [00:39:05] Ted Naiman ways to enter ketosis infographic. [00:40:50] Pitocin, brand name medication for oxytocin. [00:42:33] Marty Kendall’s Nutrient Optimiser. [00:44:41] Metabolic flexibility and undereating. [00:46:21] Podcasts: High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea with Mike T. Nelson and The Importance of Strength Training for Endurance Athlete with Mike T. Nelson. [00:46:42] Podcasts: National Cyclocross Champion Jeremy Powers on Racing, Training and the Ketogenic Diet and National Cyclocross Champion Katie Compton on Ketosis and MTHFR. [00:47:07] Keto-mojo meter. [00:48:17] What to measure. [00:49:57] Myostatin inhibition. [00:50:37] Study: Roberts, Megan N., et al. "A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice." Cell Metabolism 26.3 (2017): 539-546 and Podcast: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice with Megan Hall. [00:53:24] Metformin works so well because of multiple mechanisms. [00:54:03] Acetone. [00:54:35] Cori cycle. [00:55:49] Book: The New Evolution Diet: What Our Paleolithic Ancestors Can Teach Us about Weight Loss, Fitness, and Aging by Arthur De Vany. [00:56:41] Tracking body mass. [00:57:37] Performance benchmarks. [00:59:03] Simon Marshall and Podcast: How to Create Behaviour Change with Simon Marshall. [00:59:31] Paul Itoi, senza.us. [01:00:25] Loss aversion. [01:01:27] Podcast: Breaking Through Plateaus and Sustainable Fat-Loss with Jason Seib. [01:02:04] Studies: Bistrian, Bruce R., et al. "Nitrogen metabolism and insulin requirements in obese diabetic adults on a protein-sparing modified fast." Diabetes 25.6 (1976): 494-504 and Furber, Matthew, et al. "A 7-day high protein hypocaloric diet promotes cellular metabolic adaptations and attenuates lean mass loss in healthy males." Clinical Nutrition Experimental(2017). [01:06:30] Very similar weight loss regardless of the diet. [01:07:11] Presentation: Low Carb Breckenridge 2017: The way to a man's heart is through the stomach with Dr. Tommy Wood. [01:09:44] Keto Masterclass details. [01:10:19] Epigenetics. [01:12:13] Podcast: Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More! with Dr. Tommy Wood. [01:13:21] Price $49! [01:15:28] Get Keto Masterclass. [01:16:30] Ivor Cummins.
Panelists Brian Wang, PJ Manney, and Shawn Phillips discuss the future of fitness The future of nutrition: vertical farming, genetically modified foods, vat meat, and a computerized nutritionists that resides "onboard" "Nutraceuticals" - food as medicine.Smoking: getting the information out about how smoking harms health helped reduce smoking. But the social stigma may have moved done more. A tiered system of nutrition? The disconnect between our buff entertainers and our fat butts. Related documentary: "Bigger, Stronger, Faster."The promise of Myostatin inhibition.People that are out of shape don't realize how bad they feel. Feeling bad becomes the new normal.The crappy beta versions of human enhancement that some people are experimenting with today, often to their detriment. When will better enhancements be available?Maybe we need a drug to make us take as much joy out of activity as a five-year-old. For them it's not exercise... it's play. [This show first aired June 30, 2008.]
Robb Wolf is a former research biochemist and review editor for the Journal of Nutrition and Metabolism, is the New York Times Best-Selling Author of The Paleo Solution, and is a renowned expert in the field of ancestral health and fitness. Having been a former California State Powerlifting Champion, he coaches and consults with world-class athletes and Olympians in across a variety of sports, and he serves on the board of Directors/Advisors for Specialty Health Inc., Paleo f(x), and Paleo Magazine. Robb has also conducted seminars in nutrition, strength, and conditioning to a number of entities including NASA, Naval Special Warfare, the Canadian Light Infantry and the United States Marine Corps. His new book, Wired to Eat, comes out this year on March 8 in the UK, and on March 21 in the US - early birds can receive launch bonuses by pre-ordering the book here. Contact Robb Wolf: RobbWolf.com The Paleo Solution Podcast Robb on Facebook Robb on Twitter In this episode, we cover: Why it's harder to get into the Navy Seals than into the NFL The diet wars: calories in and calories out versus high fat and low carb How to eat well on a budget for maximum nutritional efficiency Optimal supplementation and which nutrients to watch out for What biomarkers you should be tracking to optimize improvement, and more! This episode is brought to you by Hituni.com, providers of the best online courses in high intensity training that come highly recommended by Dr. Doug McGuff and Discover Strength CEO, Luke Carlson. Course contributors include world class exercise experts like Drew Baye, Ellington Darden and Skyler Tanner. There are courses for both trainers and trainees. So even if you’re not a trainer but someone who practices HIT, this course can help you figure out how to improve your progress and get best results. Check out Hituni.com, add the course you want to your shopping cart and enter the coupon code ‘CW10’ to get 10% off your purchase!
YK11 is theorized to allow bodybuilders to inhibit the feedback loop in their body that limits how much muscle they can pack on via Myostatin inhibition. The end result of this could be increased muscle growth potential that would otherwise be impossible to achieve.…
Pioneer in the world of Gene therapy, Dr. Theodore Friedman shares with us today the exciting future of what gene therapy holds. Listen in as we hear how manipulating certain lacking or misbehaving genes from causing disease has been proven in several types of diseases through clinical experimentation and how it will benefit future generations. We discuss whether or not it will be a solution to all disease. What the census is on how fast it will take or the prediction of genomic therapy within the scientific world. Gain greater awareness of gene modification within the world sport arena (Olympics), what kind of testing has been approved, used and how the tests are able to find modified genes or the presence of agents used to deliver those editing genes. What is the ethical answer of testing in sports when certain individuals naturally have genes that give increased ability to perform at a higher level than others? Applying Gene Therapy Attack of genetic disease - using your genes as your tools for treatment rather than pharmaceutical drugs. The Molecular Biology field starting asking this question in the 1970s of how to manipulate genes in cells and living organisms to prevent the expression of disease causing genes. Introducing new genes or modifying genes with experimental testing certain diseases are being able to be manipulated or managed. How will the genes be edited with those that have existing diseases present not just a gene known to cause disease? Not all genes can be manipulated – there will still need to be preventative action, people will still have illnesses as not everyone has access to genomic testing and information on how to prevent disease through gene therapy. How will all of this sophisticated knowledge be delivered to all types of people? For gene manipulation to work the editing gene has to be delivered at the right time, to the right cell in the correct controlled situation for it to work properly. Using Gene Therapy to Enhance Sport Performance Which if you didn't hear in the 2016 Olympic Games there was testing for a gene known as EPO (Erythropoietin) within athletes. As this awareness has been around for a decade and through research and scientific understanding testing was made available for detection of EPO distributed through the AAV virus into the person's genomes. With new technology emerging testing will and will not be possible depending on how the gene is manipulated or delivered into the athlete's correct cells. Most are being edited through various agents/viruses that more often than not do leave a fingerprint or sequence that may be found in current approved tests. Other attributes of enhancing an athletes' performance is to use gene therapy to knock out or minimize a gene such as Myostatin which may inhibit muscle cell growth and differentiation. This also can be tested by looking for a mutant myostatin gene – which may be detected by a mixture of several different genomes. Don't miss the Gene Based Dieting Live Webinar happening in Early December! Learn how your genes can predict your best dietary outcomes. With amazing outcomes of over 1500 clients within our medical practice.
Every week Dr. Dan answers your questions relating to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to questions@ephysiologix.com. This week's topics: Cold Thermogenesis progress Vitamin D and weight loss What is the best way to intermittent fast? In the news: Oxytocin and stress response Genetic based dieting Fortetropin for myostatin inhibition
Live Life Aggressively Podcast w/Mike Mahler & Sincere Hogan
Dr. Carlon Colker (http://peakwellness.com) is a physician, author, network reality TV personality, public speaker, and dietary supplement industry consultant. He runs a private practice and consulting clinic in Greenwich, Connecticut (Peak Wellness, Inc.), Dr. Colker, NBA Shaquille O'Neal's personal physician and trainer for over 20 years and whom he credits with his championship condition, starred alongside Shaq on the ABC reality TV program Shaq's Big Challenge in 2007.He appeared as a guest medical correspondent on Fox News Channel's Fox & Friends; and on shows such as ESPN Outside the Lines, NBC's Health Segment, Court TV, Bloomberg, Good Morning America, and ABC's World News Tonight. Colker has authored various media articles and columnsand published several books on health-related topics, including "The Greenwich Diet," "Sex Pills: From Androstenedione to Zinc, What Works and What Doesn't," & "Extreme Muscle Enhancement: Bodybuilding's Most Powerful Techniques." Dr. Colker is also a columnist and contributing editor for Muscular Development, and has appeared in such health magazines as Muscle & Fitness, Ironman, Mind & Power, Body, Runner's World, Walking, Let's Live, Self Magazine, Strive, Men's Health, Men's Fitness, and Cosmopolitan. Dr. Colker joins Mike & Sincere to discuss: Dr. Colker shares his relationship with Shaquille O'Neal, Quinton "Rampage" Jackson, Frank Shamrock, Andre Agassi, and others How does Dr. Colker adjust to working with various personalities, especially high level athletes How to break the vicious cycle of implementing food in the place of love and guilt How did Dr. Colker & his team help lower income families have access to higher food quality How most schools are the new surrogates for busy parents & how they can help children eat healthier Dr. Colker shares how he is currently helping Quinton "Rampage" Jackson with his training, diet, and fight strategy What is Dr. Colker's connection with actor Bradley Cooper Why eating a lot can be a huge task Dr. Colker shares his current training regimen, and at 48 years old, how he makes it work What form of nutritional testing can you begin today, without spending a dime, and why it's very beneficial Why you "can" benefit from fad diets? How does Dr. Colker benefit from a high fat, low protein & carb diet What nutrient group will Dr. Colker pay $100,000 for someone to find When are carbohydrates of great benefit Dr. Colker shares how dietary fat works with the brain What was Dr. Colker's relationship with Robert Atkins Why fat is more of an energy source than carbohydrates What food resource can your consume to reduce sugar cravings What sugar is safe for diabetics and actually feeds healthy bacteria in the body What you may not know about stevia, xylitol, and other sugar alcohols What are the benefits of myostatin inhibitors All this and much more: Listen and download at http://strengthbymahler.com or http://newwarriortraining.com. or subscribe, download, rate & review us at: iTunes: https://itunes.apple.com/us/podcast/live-life-aggressively-podcast/id646524617 Stitcher: http://www.stitcher.com/s?fid=34706&refid=stpr Also, be sure to "like" and connect with us on our Facebook fan page at http://facebook.com/llapodcast.
Ming Hammond is Asst. Professor of Chemistry, Molecular & Cell Biology. Her research combines Chemical and Molecular Biology, Organic Chemistry; Reengineering functional RNAs, and mechanistic studies of RNA-based gene regulation. She created the web site youstem.org.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Okay. Speaker 1: Welcome to spectrum the science and technology show on k a l x Berkeley, a biweekly [00:00:30] 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Good afternoon. My name is Brad swift and I'm your host. Our interview is with assistant professor of chemistry and molecular and cell biology Ming Hammond. Her research combines the fields of chemical biology, organic chemistry, molecular biology and bioinformatics. Ming Hammond [00:01:00] received her bachelor of Science Degree from the California Institute of Technology and her phd from UC Berkeley. She created and maintains the website you stem.org this site consolidates opportunities in science, technology, engineering and math for primary and secondary school students in the Greater Bay area. Assistant Professor Ming Hammond. Welcome to spectrum. Hello. Thank you. Would you give us an overview of [00:01:30] the research that you're doing and in so doing, remind us what DNA and RNA are and how they're different. Speaker 1: Okay. Okay. I think a analogy that I like to use to describe the difference between DNA and RNA is that you can think of DNA as kind of an instruction manual for life. So that a very large instruction manual, several billion letters in length and it has all the instructions for how to make [00:02:00] all of the molecules, all the functioning parts of the cell RNA are messenger RNA is, are basically xerox copies of some pages of the DNA instruction manual that, um, gets used by the cell to translate the instructions into making proteins like enzymes and other components of the cell. Um, my lab is interested in how these RNA sequences are [00:02:30] regulated, how they're sent to different places in the cell and also how to change them so that we have, maybe we can control how the instructions are being used by the cell. Speaker 3: And so with that research, are you trying to create a generally applicable way to alter the RNA so that the gene is expressed differently? Speaker 1: Um, yes, exactly. And [00:03:00] first of all, understanding in nature how natural systems, um, control gene expression. And one reason we're interested in this is because for multicellular organisms like humans or plants, you have the same instruction manual in every single cell and yet you have multicellularity, right? So you have differences, different sets and instructions are being expressed [00:03:30] in different cell types, in different organs and in different portions of plants. For example, and were interested in understanding the basic mechanism for how the Messenger RNA is involved in ensuring that specific instructions are being followed in specific tissue types or specific cell types. Speaker 3: Does that then also include the idea that you mentioned of [00:04:00] certain of the messages are incorrect on purpose and so understanding that sounds complex, Speaker 1: right? So it's kind of interesting that one of the ways in which you can control, for example, whether a specific gene is expressed in the heart versus in the liver or the brain for example, is that messenger RNA for the same gene in the [00:04:30] brain is correct and can give rise to the proper protein and in the heart the same gene set of instructions can be spliced into messenger RNA in this specific way. That gives you a slightly different form of the protein. For example, one that has a slightly different function and therefore specific for that tissue. And then in the other case that I described, you might find in yet another tissue type that the same [00:05:00] message can be spliced so that it actually has a signal that says this is a garbage sequence, this is a nonsense message, don't follow this message. And the sal is smart enough to read these nonsense messages and know them to be nonsense. And what they do is the cell actually degrades these RNA. So for example, in that specific tissue type that the protein is never made. And so that's how you get [00:05:30] specialization of self. Speaker 3: And in your research are you trying to understand all of those cases? Speaker 1: We do most of our work in plants and we're very interested in the case where you can effectively shut off Accion in one condition, in war one cell type versus having it on or expressed in another cell type. So in plants, the mechanism that we study is [00:06:00] how these messages are lysed in these different ways. And that's called alternative splicing. And the predominant function of alternative spicing and plants appears to be this latter case where the messages either made and it's correct or it's made and has nonsense, but the reason I mentioned the other case is that it turns out something that's differentiates humans, for example, or mammals from plants. Besides the obvious differences, but a subtle [00:06:30] difference. The one I'm interested in is it turns out the majority of alternative splicing in mammals is actually to make different forms of that protein, so it's kind of interesting how the same basic mechanism is used by different organisms to do different things. Speaker 4: [inaudible]Speaker 3: you were listening to spectrum on k a l x Berkeley. Today we're talking with assistant professor Ming Hammond about [00:07:00] her work in messenger RNA and gene expression Speaker 4: [inaudible]Speaker 3: does the nonsense message have some value that you are researching that you are interested in understanding what is, what is the value of it to the, to the organism. Speaker 1: Okay. It's very important for the organism in general that the cell needs to have a way to know when a message or when a messenger RNA is [00:07:30] instructing nonsense because it's actually known that you can have mutations, for example, if you have a mutation in your gene that gives you a bad message. If sometimes that message then gets expressed as a protein, that protein with this altered function or ane may in fact lead to detrimental results, bad results for the south. Right. Um, and so, um, in general, the, there's a, [00:08:00] we call it a surveillance mechanism, so the cell is actually looking out for dad copies of the Messenger RNA. And so the cell normally has these surveillance mechanisms to, to, to play a very important role in keeping the, and keeping the cell healthy. And so I think what has happened is that the cell has started exploiting this mechanism to regulate chains for [00:08:30] tissue specificity and all of these other things I mentioned Speaker 3: in this regard. Are some cells smarter than others? Speaker 1: Hmm. I, I wouldn't say that [inaudible] Speaker 3: in terms of evolutionary activity, it would seem that this is kind of the place where that might go on in terms of changing an organism over time. How would RNA and nonsense allow for some sort of an evolutionary capacity to happen? Speaker 1: Okay. [00:09:00] First of all, the surveillance mechanism does not change the genomic DNA or she does not change the DNA instruction manual. Speaker 3: It's too far down the pipeline, right? So it's just reacting to the DNA instruction set, right? So it's really not there that any evolutionary activity is going to happen. It's going to happen at the higher lows. Right? Speaker 1: There are people that look to see for example, which, uh, which organisms do have this mechanism, right? So it's not that [00:09:30] some cells are smarter than others, but more that there are some organisms that don't have this surveillance pathway, for example. And bacteria do not, as far as we know, have NMD pathways, um, this nonsense mediated decay pathways, but a lot of organisms with a nucleus to have this mechanism. But one of the things that we're interested in in the lab is there is a lot of people that study this mechanism in humans and in other mammals. [00:10:00] And we're working in this in plants and we're looking at the comparison between them. What are the differences and what are the things that are similar Speaker 3: in your research? I noticed that there's something called molecular sensing that you're interested in. Can you explain that? Speaker 1: Sure. So, um, I mentioned that were studying how gene expression is regulated at the RNA level. And one of the really fascinating [00:10:30] things that I worked on as first as a postdoc and now that we're still working on in the lab is it turns out some of the Messenger RNA [inaudible] that exist in bacteria don't just encode the sequences for making proteins. But there is a little extra part of the Messenger RNA in the beginning part of the messenger RNA sequence that encodes what we call a ribo [00:11:00] switch. You can think about the riboswitch as basically a natural chemical sensor that's hooked up to the Messenger RNA. And what the rabis switch does is it responds to the presence of a chemical, for example, whether there is plenty of an amino acid in the south and the RNA is able to sense the presence of say the [00:11:30] amino acid and when it binds to this chemical, it changes its shape and through this confirmation or shape change, it causes the message downstream to actually get shut off. If you have enough of the amino acid, you turn off the gene that is used to make that amino acid because you don't need anymore. So I turns out there are many, many of these rabis switches [00:12:00] performing this simple chemical, boolean logic at the RNA level doing molecular sensing and in my lab were of course interested in the natural, these natural ones. And we're also interested in making unnatural ones as well. Speaker 3: And how is it that you utilize that information? Speaker 1: One way you can make use of the [inaudible] switch as I mentioned, is that its normal function is to turn on or turn off a chain depending on [00:12:30] the natural chemical logic is. So it turns out you can take the DNA sequence that encodes the ribo switch and you could put it in front of a different gene. And now that other gene also responds to this chemical. So it's actually a portable logic gate, so to speak. And what we're interested in is in making new Ribas switches, for example, making ones that can work in plants [00:13:00] because there is so far as we know, only one natural rubber switch that functions in plants and were interested in exploring whether we can transport these chemical sensors and utilize them and in other organisms including plant. Speaker 5: This is spectrum. I'm k a l x Berkeley. We're talking with the assistant professor Ming Hammond [00:13:30] about her research with messenger RNA and how it interacts with DNA genes. [inaudible] Speaker 3: so are you building those pre-IPO switches yourself or are you borrowing them from other organisms? Speaker 1: Um, well I would say it's actually a mix of both. We are also fundamentally interested in the mechanics of it too, right? How, how riboswitch with dysfunction. What is really amazing about Rabis, which is [00:14:00] is that there are so many different species of bacteria that utilize these Ribas switches and these bacteria live in all different types of climates than of them can live in extreme temperatures, both hot and cold and others are more, you know, soil dwelling organisms and live at pretty close to room temperature and all of them have the same sensor. And it's kind of an interesting question to ask how it is that the same sensor works [00:14:30] in all of these organisms? What part of the sequence of the, the switch of the RNA is responsible for for that [inaudible]. Speaker 3: So largely you, you work from the gene DNA area down into the RNA to control the expression of that gene. Speaker 1: Everything that we do does start the DNA level and we have in mind and designed for messenger RNA that we want. And then we can go back and say, okay, [00:15:00] at the DNA level, this is what the DNA instructions have to be to make that messenger RNA. And then we see, okay, let's build it weak. Then express it and see, okay, is the RNA doing? What we want it to and then further on is this messenger RNA being shut off the way that we want it to under this condition and then turned on under a different set of conditions. Speaker 3: And how do you judge whether or not you've had success? Is it pretty black and white [00:15:30] or is it somewhat gray? Speaker 1: One of the kind of very basic techniques that we use is a very simple assay. So you can imagine if we wanted to see whether under condition a this messenger RNA we designed is not making the protein versus condition B when when it is. So what we ended up using is what we call a reporter gene, a gene that expresses a protein that is fluorescent so that if [00:16:00] you shine light at a certain wavelength, you get a light emission from this protein. So we express the gene and in this case on the surface of the plant leaf and we can scan the leaf and let's say condition a is on the left hand side and condition B is on the right hand side. And we'll actually see that the right hand side, the leaf will be glowing and the left hand side of leaf not be glowing because of Ganar that we use to tact [00:16:30] the light emission from the surface of the leaf. Uh, it actually shows up as a gray scale limit. So that's how it turns out. Speaker 3: The organisms that you're currently working with, how do you select them? Speaker 1: One of the ways that you would want to select an organism is, is that other people have worked with the organism and that it's been shown by other researchers that it's easy to do the experiments that you're planning and that there are protocols developed for the experiments [00:17:00] that you're planning. And so it's kind of expedient, but we pick a plant called Nicole [inaudible], Tami Ana that is actually cousin to the tobacco plant, which is of some agricultural interests and also has been shown by other people to be very easy to work with for our experiments. Speaker 3: How has the hardware and the software that you use to do your research changed over the past? What 10 years that you've been doing this [inaudible] Speaker 1: [00:17:30] so we don't actually use much software. We can talk about the hardware. Sure we can like the development of technology to do DNA sequencing very, very rapidly has really been astonishing to see. And for my research in the RNA field, it has an equal impact I would say as well because it turns out if you want to study an RNA sequence, one of the ways we study it is that we do what's called a [00:18:00] reverse transcription. So we convert the RNA back to DNA and then we sequence the DNA that's made from the RNA. So it's kind of the reverse of the normal case of things that technology has enabled people to not just look at the human genome, but what we called a human transcriptome. So this is what are all the Messenger RNHS that are being expressed in different tissue types. And so that has led us to discovering, for [00:18:30] example, these differences in expression at different, um, messenger RNA is on a much, much grander scale. It much, much higher throughput scale than was possible 10 15 years ago. More fundamentally, it has made certain experiments that were impossible to do possible. Now the next challenge is how to sort through all that data Speaker 6: [inaudible]Speaker 5: you are tuned to k a l [00:19:00] x Berkeley. You're listening to spectrum. We're talking with Assistant Professor Mang Hammond about RNA based gene regulation Speaker 6: [inaudible].Speaker 1: Can you explain the a youth stem.org website and I believe you started this, didn't right. So my lab and I started this website called youth stem.org and the inspiration for the website is, it's actually kind of a personal story, [00:19:30] but I think it resonates with a lot of young scientists and other scientists is when I was a younger student, even before I went off to college and I was deciding what subjects I liked, what I like to do, I had these opportunities where yes, some of my science teachers saw something in me or thought that I would enjoy science and wanted to encourage me in the sciences and they would suggest that I go and do some of these programs that [00:20:00] are available in the state of Maryland, for example, where my family is from. And you know, I had a chance to work in a lab at the University of Maryland School of Pharmacy. Speaker 1: And I remember that made a really big impression on me when I was a freshman in college. And my freshman advisor asked me what I wanted to do for work study. I said that, well of course I wanted to do research in a lab because I said why I was already in a lab and in high school and I really liked it [00:20:30] and that's what I want to do for work study. And it was really exciting and really fun. So that's the origin story I guess of you stem. And in fact we have a lot of programs on the Berkeley campus for students interested in science that are, and that some of which pay actually a stipend. And not everyone can afford to pay money to do a summer program, but we have these free programs [00:21:00] that are I think really great. So I wanted to have a mechanism to point that out to local area students. Speaker 1: And the kind of idea I had was, well wouldn't it be great if we had like essentially a craigslist for bay area free local science and engineering and math programs? And so that's um, basically what we intend for a stem to be. [00:21:30] You can actually go on the website. It's you stem.org and you can click on a subject. You know, my favorite subject of course is chemistry. And so you could pick chemistry and it'll actually show you just the programs that are for students interested in chemistry. You can search by your grade and it tell you which programs are for you or you also filter by the location. So we're focused a lot on the East Bay, but there are also programs down in the South Bay down [00:22:00] in San Jose, Santa Cruz that we found in ones up in Monterrey. Speaker 3: So for people locally within the bay area who do have programs, they could contact you through the web. Speaker 1: Right? There's actually a link on the bottoms saying you're saying if you're a program director and you would like to list your program, the criteria is that we're interested in listing programs where the students can apply themselves or it can be nominated by a teacher that it's open to [00:22:30] any student that wants to apply. And uh, certainly we emphasize programs that are free or that pass state band. Speaker 3: And you recently received the NIH director's new innovator award. How did that happen? Speaker 1: Well, the short answer is I applied but um, yes. So it's, it's a really great honor to have received it and actually [00:23:00] to a members of the chemistry department received the new innovator where I this year, myself and Michelle Chang, another assistant professor in the same department. And so it, that was just really great news for both of us. And yeah, it was really a day for celebration in the lab for sure. I mean Hammon thanks very much for coming on spectrum. Thank you. It's a pleasure to be here. Thanks for having me. Brad. Speaker 6: [inaudible]Speaker 3: [00:23:30] irregular feature of spectrum is to mention a few of the science and technology events happening locally over the next few weeks. Rick Kaneski joins me for the calendar. Speaker 7: Come to nerd night [00:24:00] on Wednesday, January 18th at the rickshaw stop, one 55 [inaudible] street at Venice in San Francisco, doors at seven 30 show at eight. All ages are welcome to this $8 show at this month and our night copies of the inaugural issue of nerd night magazine will be given away. There's an article in there about cephalopod sex by the bay area's own. Rich Ross, Robyn, sue Fisher and Corey bloom will share their stories of liquid nitrogen ice cream. Their company smitten in San Francisco's first [00:24:30] made to order scoop shop and they will show off the engineering marvel that is dubbed to Kelvin that can churn up ice cream in under a minute. What do you love? Bounty and David Gallagher. We'll present Carville by the sea. San Francisco's Streetcar, suburb, and you CSF, Phd Student Tsai. Dear Etsy, we'll talk about antibody engineering and how artificially created antibodies can or will eventually fight disease. Visit s F. Dot. [inaudible] dot com for more information, Speaker 3: smoke [00:25:00] and mirrors is geoengineering a solution to global warming. Professor Alan Robock from the Department of Environmental Sciences at Rutgers University will address this question. Wednesday, January 25th 4:00 PM in Barrels Hall Room One 10 on the UC Berkeley campus. This event is free and open to the public Speaker 7: on Thursday, January 26th from seven to 9:00 PM the bone room at 1573 Solano avenue in Berkeley or present [00:25:30] eye to compound eye, the art and science of insect photography. In this free lecture insect photographer Becky Jaffe will incorporate and it dotes from biology, ecology and cultural anthropology to offer an engaging account of her field experiences that will inspire you to pick up the camera and look at insects with new eyes. Visit www.boneroompresents.com for more information now a few news items. Here's the Rick science [00:26:00] news reviews. A January 5th article in science by Sandra Garrett and Joshua Rosenthal at the University of Puerto Rico Medical Sciences campus in San Juan that shows that while octopuses in the Arctic have very similar DNA with warm water octopuses, their nerve cells are very different. This difference allows them to operate in the frigid waters and arises due to m RNA edits. These edits change the way that nerve cells opening includes gates to produce electrical impulses based on the species of octopus. This is the first [00:26:30] discovered example of m RNA editing to help an organism adapt to its environment and speculation remains as to how quickly and prevalent the mechanism might be. Speaker 3: In December, NASA announced seventh 2012 as the new target launch date for the space x commercial orbital transportation services milestone missions two and three. This mission begins with the liftoff of the Falcon nine rocket from Cape Canaveral boosting the Dragon's [00:27:00] spacecraft into low earth orbit. The space x dragon spacecraft will perform all of the commercial orbital transportation services, milestone mission two objectives, which include numerous operations in the vicinity of the International Space Station, and thereafter we'll perform the commercial orbital transportation services milestone mission three objectives. These include approach birthing with the International Space Station, astronauts opening the dragon spacecraft [00:27:30] and unloading cargo. Finally, the astronauts will close the space craft and send it back to Earth for recovery from the Pacific Ocean off the coast of California. This mission, if successful, will mark a major milestone in commercial American space flight Speaker 7: did January 4th issue of the Journal of neuroscience has an article by UCLA is Jenn Lang and others that reports promising anti-alcohol effects of a seed extract from the Asian Havana Dakis or Japanese [00:28:00] raising tree. This was first claimed to be a hangover remedy in the year six five nine rats that took dihydro, Myostatin or [inaudible] were found to take longer to become intoxicated and recovered four times more quickly than rats who did not take the extract. The extract further decrease the likelihood of hangover, anxiety and seizures in the rats. DSM also curved alcohol consumption. Rats consumed more and more alcohol gradually when it allowed, but d h m leased alcohol does not lead to this increased [00:28:30] consumption. DHM blocks alcohol's effects on Gaba receptors and the team has found no side effects in animal testing. They old next study the health effects on people Speaker 2: [inaudible]Speaker 4: the music heard during the show is from a low stone, a David album titled Folk and Acoustic released under a creative Commons attribution license 3.0 Speaker 2: [00:29:00] [inaudible] Speaker 4: production assistance from Rick Karnofsky Speaker 2: [inaudible].Speaker 4: Thank you for listening to spectrum. We are happy to hear from listeners. If you have comments about the show, please send them to us via email. [00:29:30] Our email address is spectrum dot k l x@yahoo.com join us in two weeks at the same time. [inaudible]. Hosted on Acast. See acast.com/privacy for more information.
Ming Hammond is Asst. Professor of Chemistry, Molecular & Cell Biology. Her research combines Chemical and Molecular Biology, Organic Chemistry; Reengineering functional RNAs, and mechanistic studies of RNA-based gene regulation. She created the web site youstem.org.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Okay. Speaker 1: Welcome to spectrum the science and technology show on k a l x Berkeley, a biweekly [00:00:30] 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Good afternoon. My name is Brad swift and I'm your host. Our interview is with assistant professor of chemistry and molecular and cell biology Ming Hammond. Her research combines the fields of chemical biology, organic chemistry, molecular biology and bioinformatics. Ming Hammond [00:01:00] received her bachelor of Science Degree from the California Institute of Technology and her phd from UC Berkeley. She created and maintains the website you stem.org this site consolidates opportunities in science, technology, engineering and math for primary and secondary school students in the Greater Bay area. Assistant Professor Ming Hammond. Welcome to spectrum. Hello. Thank you. Would you give us an overview of [00:01:30] the research that you're doing and in so doing, remind us what DNA and RNA are and how they're different. Speaker 1: Okay. Okay. I think a analogy that I like to use to describe the difference between DNA and RNA is that you can think of DNA as kind of an instruction manual for life. So that a very large instruction manual, several billion letters in length and it has all the instructions for how to make [00:02:00] all of the molecules, all the functioning parts of the cell RNA are messenger RNA is, are basically xerox copies of some pages of the DNA instruction manual that, um, gets used by the cell to translate the instructions into making proteins like enzymes and other components of the cell. Um, my lab is interested in how these RNA sequences are [00:02:30] regulated, how they're sent to different places in the cell and also how to change them so that we have, maybe we can control how the instructions are being used by the cell. Speaker 3: And so with that research, are you trying to create a generally applicable way to alter the RNA so that the gene is expressed differently? Speaker 1: Um, yes, exactly. And [00:03:00] first of all, understanding in nature how natural systems, um, control gene expression. And one reason we're interested in this is because for multicellular organisms like humans or plants, you have the same instruction manual in every single cell and yet you have multicellularity, right? So you have differences, different sets and instructions are being expressed [00:03:30] in different cell types, in different organs and in different portions of plants. For example, and were interested in understanding the basic mechanism for how the Messenger RNA is involved in ensuring that specific instructions are being followed in specific tissue types or specific cell types. Speaker 3: Does that then also include the idea that you mentioned of [00:04:00] certain of the messages are incorrect on purpose and so understanding that sounds complex, Speaker 1: right? So it's kind of interesting that one of the ways in which you can control, for example, whether a specific gene is expressed in the heart versus in the liver or the brain for example, is that messenger RNA for the same gene in the [00:04:30] brain is correct and can give rise to the proper protein and in the heart the same gene set of instructions can be spliced into messenger RNA in this specific way. That gives you a slightly different form of the protein. For example, one that has a slightly different function and therefore specific for that tissue. And then in the other case that I described, you might find in yet another tissue type that the same [00:05:00] message can be spliced so that it actually has a signal that says this is a garbage sequence, this is a nonsense message, don't follow this message. And the sal is smart enough to read these nonsense messages and know them to be nonsense. And what they do is the cell actually degrades these RNA. So for example, in that specific tissue type that the protein is never made. And so that's how you get [00:05:30] specialization of self. Speaker 3: And in your research are you trying to understand all of those cases? Speaker 1: We do most of our work in plants and we're very interested in the case where you can effectively shut off Accion in one condition, in war one cell type versus having it on or expressed in another cell type. So in plants, the mechanism that we study is [00:06:00] how these messages are lysed in these different ways. And that's called alternative splicing. And the predominant function of alternative spicing and plants appears to be this latter case where the messages either made and it's correct or it's made and has nonsense, but the reason I mentioned the other case is that it turns out something that's differentiates humans, for example, or mammals from plants. Besides the obvious differences, but a subtle [00:06:30] difference. The one I'm interested in is it turns out the majority of alternative splicing in mammals is actually to make different forms of that protein, so it's kind of interesting how the same basic mechanism is used by different organisms to do different things. Speaker 4: [inaudible]Speaker 3: you were listening to spectrum on k a l x Berkeley. Today we're talking with assistant professor Ming Hammond about [00:07:00] her work in messenger RNA and gene expression Speaker 4: [inaudible]Speaker 3: does the nonsense message have some value that you are researching that you are interested in understanding what is, what is the value of it to the, to the organism. Speaker 1: Okay. It's very important for the organism in general that the cell needs to have a way to know when a message or when a messenger RNA is [00:07:30] instructing nonsense because it's actually known that you can have mutations, for example, if you have a mutation in your gene that gives you a bad message. If sometimes that message then gets expressed as a protein, that protein with this altered function or ane may in fact lead to detrimental results, bad results for the south. Right. Um, and so, um, in general, the, there's a, [00:08:00] we call it a surveillance mechanism, so the cell is actually looking out for dad copies of the Messenger RNA. And so the cell normally has these surveillance mechanisms to, to, to play a very important role in keeping the, and keeping the cell healthy. And so I think what has happened is that the cell has started exploiting this mechanism to regulate chains for [00:08:30] tissue specificity and all of these other things I mentioned Speaker 3: in this regard. Are some cells smarter than others? Speaker 1: Hmm. I, I wouldn't say that [inaudible] Speaker 3: in terms of evolutionary activity, it would seem that this is kind of the place where that might go on in terms of changing an organism over time. How would RNA and nonsense allow for some sort of an evolutionary capacity to happen? Speaker 1: Okay. [00:09:00] First of all, the surveillance mechanism does not change the genomic DNA or she does not change the DNA instruction manual. Speaker 3: It's too far down the pipeline, right? So it's just reacting to the DNA instruction set, right? So it's really not there that any evolutionary activity is going to happen. It's going to happen at the higher lows. Right? Speaker 1: There are people that look to see for example, which, uh, which organisms do have this mechanism, right? So it's not that [00:09:30] some cells are smarter than others, but more that there are some organisms that don't have this surveillance pathway, for example. And bacteria do not, as far as we know, have NMD pathways, um, this nonsense mediated decay pathways, but a lot of organisms with a nucleus to have this mechanism. But one of the things that we're interested in in the lab is there is a lot of people that study this mechanism in humans and in other mammals. [00:10:00] And we're working in this in plants and we're looking at the comparison between them. What are the differences and what are the things that are similar Speaker 3: in your research? I noticed that there's something called molecular sensing that you're interested in. Can you explain that? Speaker 1: Sure. So, um, I mentioned that were studying how gene expression is regulated at the RNA level. And one of the really fascinating [00:10:30] things that I worked on as first as a postdoc and now that we're still working on in the lab is it turns out some of the Messenger RNA [inaudible] that exist in bacteria don't just encode the sequences for making proteins. But there is a little extra part of the Messenger RNA in the beginning part of the messenger RNA sequence that encodes what we call a ribo [00:11:00] switch. You can think about the riboswitch as basically a natural chemical sensor that's hooked up to the Messenger RNA. And what the rabis switch does is it responds to the presence of a chemical, for example, whether there is plenty of an amino acid in the south and the RNA is able to sense the presence of say the [00:11:30] amino acid and when it binds to this chemical, it changes its shape and through this confirmation or shape change, it causes the message downstream to actually get shut off. If you have enough of the amino acid, you turn off the gene that is used to make that amino acid because you don't need anymore. So I turns out there are many, many of these rabis switches [00:12:00] performing this simple chemical, boolean logic at the RNA level doing molecular sensing and in my lab were of course interested in the natural, these natural ones. And we're also interested in making unnatural ones as well. Speaker 3: And how is it that you utilize that information? Speaker 1: One way you can make use of the [inaudible] switch as I mentioned, is that its normal function is to turn on or turn off a chain depending on [00:12:30] the natural chemical logic is. So it turns out you can take the DNA sequence that encodes the ribo switch and you could put it in front of a different gene. And now that other gene also responds to this chemical. So it's actually a portable logic gate, so to speak. And what we're interested in is in making new Ribas switches, for example, making ones that can work in plants [00:13:00] because there is so far as we know, only one natural rubber switch that functions in plants and were interested in exploring whether we can transport these chemical sensors and utilize them and in other organisms including plant. Speaker 5: This is spectrum. I'm k a l x Berkeley. We're talking with the assistant professor Ming Hammond [00:13:30] about her research with messenger RNA and how it interacts with DNA genes. [inaudible] Speaker 3: so are you building those pre-IPO switches yourself or are you borrowing them from other organisms? Speaker 1: Um, well I would say it's actually a mix of both. We are also fundamentally interested in the mechanics of it too, right? How, how riboswitch with dysfunction. What is really amazing about Rabis, which is [00:14:00] is that there are so many different species of bacteria that utilize these Ribas switches and these bacteria live in all different types of climates than of them can live in extreme temperatures, both hot and cold and others are more, you know, soil dwelling organisms and live at pretty close to room temperature and all of them have the same sensor. And it's kind of an interesting question to ask how it is that the same sensor works [00:14:30] in all of these organisms? What part of the sequence of the, the switch of the RNA is responsible for for that [inaudible]. Speaker 3: So largely you, you work from the gene DNA area down into the RNA to control the expression of that gene. Speaker 1: Everything that we do does start the DNA level and we have in mind and designed for messenger RNA that we want. And then we can go back and say, okay, [00:15:00] at the DNA level, this is what the DNA instructions have to be to make that messenger RNA. And then we see, okay, let's build it weak. Then express it and see, okay, is the RNA doing? What we want it to and then further on is this messenger RNA being shut off the way that we want it to under this condition and then turned on under a different set of conditions. Speaker 3: And how do you judge whether or not you've had success? Is it pretty black and white [00:15:30] or is it somewhat gray? Speaker 1: One of the kind of very basic techniques that we use is a very simple assay. So you can imagine if we wanted to see whether under condition a this messenger RNA we designed is not making the protein versus condition B when when it is. So what we ended up using is what we call a reporter gene, a gene that expresses a protein that is fluorescent so that if [00:16:00] you shine light at a certain wavelength, you get a light emission from this protein. So we express the gene and in this case on the surface of the plant leaf and we can scan the leaf and let's say condition a is on the left hand side and condition B is on the right hand side. And we'll actually see that the right hand side, the leaf will be glowing and the left hand side of leaf not be glowing because of Ganar that we use to tact [00:16:30] the light emission from the surface of the leaf. Uh, it actually shows up as a gray scale limit. So that's how it turns out. Speaker 3: The organisms that you're currently working with, how do you select them? Speaker 1: One of the ways that you would want to select an organism is, is that other people have worked with the organism and that it's been shown by other researchers that it's easy to do the experiments that you're planning and that there are protocols developed for the experiments [00:17:00] that you're planning. And so it's kind of expedient, but we pick a plant called Nicole [inaudible], Tami Ana that is actually cousin to the tobacco plant, which is of some agricultural interests and also has been shown by other people to be very easy to work with for our experiments. Speaker 3: How has the hardware and the software that you use to do your research changed over the past? What 10 years that you've been doing this [inaudible] Speaker 1: [00:17:30] so we don't actually use much software. We can talk about the hardware. Sure we can like the development of technology to do DNA sequencing very, very rapidly has really been astonishing to see. And for my research in the RNA field, it has an equal impact I would say as well because it turns out if you want to study an RNA sequence, one of the ways we study it is that we do what's called a [00:18:00] reverse transcription. So we convert the RNA back to DNA and then we sequence the DNA that's made from the RNA. So it's kind of the reverse of the normal case of things that technology has enabled people to not just look at the human genome, but what we called a human transcriptome. So this is what are all the Messenger RNHS that are being expressed in different tissue types. And so that has led us to discovering, for [00:18:30] example, these differences in expression at different, um, messenger RNA is on a much, much grander scale. It much, much higher throughput scale than was possible 10 15 years ago. More fundamentally, it has made certain experiments that were impossible to do possible. Now the next challenge is how to sort through all that data Speaker 6: [inaudible]Speaker 5: you are tuned to k a l [00:19:00] x Berkeley. You're listening to spectrum. We're talking with Assistant Professor Mang Hammond about RNA based gene regulation Speaker 6: [inaudible].Speaker 1: Can you explain the a youth stem.org website and I believe you started this, didn't right. So my lab and I started this website called youth stem.org and the inspiration for the website is, it's actually kind of a personal story, [00:19:30] but I think it resonates with a lot of young scientists and other scientists is when I was a younger student, even before I went off to college and I was deciding what subjects I liked, what I like to do, I had these opportunities where yes, some of my science teachers saw something in me or thought that I would enjoy science and wanted to encourage me in the sciences and they would suggest that I go and do some of these programs that [00:20:00] are available in the state of Maryland, for example, where my family is from. And you know, I had a chance to work in a lab at the University of Maryland School of Pharmacy. Speaker 1: And I remember that made a really big impression on me when I was a freshman in college. And my freshman advisor asked me what I wanted to do for work study. I said that, well of course I wanted to do research in a lab because I said why I was already in a lab and in high school and I really liked it [00:20:30] and that's what I want to do for work study. And it was really exciting and really fun. So that's the origin story I guess of you stem. And in fact we have a lot of programs on the Berkeley campus for students interested in science that are, and that some of which pay actually a stipend. And not everyone can afford to pay money to do a summer program, but we have these free programs [00:21:00] that are I think really great. So I wanted to have a mechanism to point that out to local area students. Speaker 1: And the kind of idea I had was, well wouldn't it be great if we had like essentially a craigslist for bay area free local science and engineering and math programs? And so that's um, basically what we intend for a stem to be. [00:21:30] You can actually go on the website. It's you stem.org and you can click on a subject. You know, my favorite subject of course is chemistry. And so you could pick chemistry and it'll actually show you just the programs that are for students interested in chemistry. You can search by your grade and it tell you which programs are for you or you also filter by the location. So we're focused a lot on the East Bay, but there are also programs down in the South Bay down [00:22:00] in San Jose, Santa Cruz that we found in ones up in Monterrey. Speaker 3: So for people locally within the bay area who do have programs, they could contact you through the web. Speaker 1: Right? There's actually a link on the bottoms saying you're saying if you're a program director and you would like to list your program, the criteria is that we're interested in listing programs where the students can apply themselves or it can be nominated by a teacher that it's open to [00:22:30] any student that wants to apply. And uh, certainly we emphasize programs that are free or that pass state band. Speaker 3: And you recently received the NIH director's new innovator award. How did that happen? Speaker 1: Well, the short answer is I applied but um, yes. So it's, it's a really great honor to have received it and actually [00:23:00] to a members of the chemistry department received the new innovator where I this year, myself and Michelle Chang, another assistant professor in the same department. And so it, that was just really great news for both of us. And yeah, it was really a day for celebration in the lab for sure. I mean Hammon thanks very much for coming on spectrum. Thank you. It's a pleasure to be here. Thanks for having me. Brad. Speaker 6: [inaudible]Speaker 3: [00:23:30] irregular feature of spectrum is to mention a few of the science and technology events happening locally over the next few weeks. Rick Kaneski joins me for the calendar. Speaker 7: Come to nerd night [00:24:00] on Wednesday, January 18th at the rickshaw stop, one 55 [inaudible] street at Venice in San Francisco, doors at seven 30 show at eight. All ages are welcome to this $8 show at this month and our night copies of the inaugural issue of nerd night magazine will be given away. There's an article in there about cephalopod sex by the bay area's own. Rich Ross, Robyn, sue Fisher and Corey bloom will share their stories of liquid nitrogen ice cream. Their company smitten in San Francisco's first [00:24:30] made to order scoop shop and they will show off the engineering marvel that is dubbed to Kelvin that can churn up ice cream in under a minute. What do you love? Bounty and David Gallagher. We'll present Carville by the sea. San Francisco's Streetcar, suburb, and you CSF, Phd Student Tsai. Dear Etsy, we'll talk about antibody engineering and how artificially created antibodies can or will eventually fight disease. Visit s F. Dot. [inaudible] dot com for more information, Speaker 3: smoke [00:25:00] and mirrors is geoengineering a solution to global warming. Professor Alan Robock from the Department of Environmental Sciences at Rutgers University will address this question. Wednesday, January 25th 4:00 PM in Barrels Hall Room One 10 on the UC Berkeley campus. This event is free and open to the public Speaker 7: on Thursday, January 26th from seven to 9:00 PM the bone room at 1573 Solano avenue in Berkeley or present [00:25:30] eye to compound eye, the art and science of insect photography. In this free lecture insect photographer Becky Jaffe will incorporate and it dotes from biology, ecology and cultural anthropology to offer an engaging account of her field experiences that will inspire you to pick up the camera and look at insects with new eyes. Visit www.boneroompresents.com for more information now a few news items. Here's the Rick science [00:26:00] news reviews. A January 5th article in science by Sandra Garrett and Joshua Rosenthal at the University of Puerto Rico Medical Sciences campus in San Juan that shows that while octopuses in the Arctic have very similar DNA with warm water octopuses, their nerve cells are very different. This difference allows them to operate in the frigid waters and arises due to m RNA edits. These edits change the way that nerve cells opening includes gates to produce electrical impulses based on the species of octopus. This is the first [00:26:30] discovered example of m RNA editing to help an organism adapt to its environment and speculation remains as to how quickly and prevalent the mechanism might be. Speaker 3: In December, NASA announced seventh 2012 as the new target launch date for the space x commercial orbital transportation services milestone missions two and three. This mission begins with the liftoff of the Falcon nine rocket from Cape Canaveral boosting the Dragon's [00:27:00] spacecraft into low earth orbit. The space x dragon spacecraft will perform all of the commercial orbital transportation services, milestone mission two objectives, which include numerous operations in the vicinity of the International Space Station, and thereafter we'll perform the commercial orbital transportation services milestone mission three objectives. These include approach birthing with the International Space Station, astronauts opening the dragon spacecraft [00:27:30] and unloading cargo. Finally, the astronauts will close the space craft and send it back to Earth for recovery from the Pacific Ocean off the coast of California. This mission, if successful, will mark a major milestone in commercial American space flight Speaker 7: did January 4th issue of the Journal of neuroscience has an article by UCLA is Jenn Lang and others that reports promising anti-alcohol effects of a seed extract from the Asian Havana Dakis or Japanese [00:28:00] raising tree. This was first claimed to be a hangover remedy in the year six five nine rats that took dihydro, Myostatin or [inaudible] were found to take longer to become intoxicated and recovered four times more quickly than rats who did not take the extract. The extract further decrease the likelihood of hangover, anxiety and seizures in the rats. DSM also curved alcohol consumption. Rats consumed more and more alcohol gradually when it allowed, but d h m leased alcohol does not lead to this increased [00:28:30] consumption. DHM blocks alcohol's effects on Gaba receptors and the team has found no side effects in animal testing. They old next study the health effects on people Speaker 2: [inaudible]Speaker 4: the music heard during the show is from a low stone, a David album titled Folk and Acoustic released under a creative Commons attribution license 3.0 Speaker 2: [00:29:00] [inaudible] Speaker 4: production assistance from Rick Karnofsky Speaker 2: [inaudible].Speaker 4: Thank you for listening to spectrum. We are happy to hear from listeners. If you have comments about the show, please send them to us via email. [00:29:30] Our email address is spectrum dot k l x@yahoo.com join us in two weeks at the same time. [inaudible]. See acast.com/privacy for privacy and opt-out information.
Keith and Kirk discuss religeous liberty issues and a balanced view of the Christian concept of the separation of church and state. Also, do beneficial mutations prove macro-evolution occurs?
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