Podcasts about accommodations

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Best podcasts about accommodations

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Latest podcast episodes about accommodations

Bringing the Human back to Human Resources
228. Navigating HR Policies in a Changing Political Landscape

Bringing the Human back to Human Resources

Play Episode Listen Later May 20, 2025 31:48


Go to https://cozyearth.com and use code HUMANHR for 40% off their best-selling sheets, pajamas, towels, and more. And if you get a post-purchase survey? Let them know you heard about Cozy Earth right here.In this episode of the Bringing the Human Back to Human Resources podcast, Traci Chernoff and Bryan Driscoll discuss recent updates in HR policies, focusing on independent contractor enforcement, employee classification, and the implications of automation and AI on the workforce. They explore the political fluctuations affecting HR regulations, the importance of understanding state laws, and the risks associated with misclassification. The conversation also highlights a recent SHRM data brief on automation displacement, emphasizing the need for upskilling and the potential biases in AI hiring practices. The episode concludes with a discussion on the legal responsibilities of employers in accommodating candidates and the necessity of regular audits of hiring tools.Chapters00:00 Introduction to Policy Pulse and Independent Contractor Enforcement03:01 Understanding Employee Classification and Political Whiplash05:49 Private Lawsuits and State Laws on Misclassification09:13 Recommendations for HR on Classification and Compliance12:07 SHRM Data Brief on Automation Displacement14:55 Implications of Automation on Workforce and Upskilling17:56 AI Bias and Discrimination in Hiring Practices20:54 Legal Responsibilities and Accommodations in Hiring24:00 Conclusion and Future Insights on Employment LawDon't forget to rate, review, and subscribe! Plus, leave a comment if you're catching this episode on Spotify or YouTube.We hope you enjoyed this month's Policy Pulse episode. If you found our discussion insightful, we'd like you to take a moment to rate our podcast. Your feedback helps us grow and reach more listeners who are passionate about these topics. You can also leave a review and tell us what you loved or what you'd like to hear more of - we're all ears!Connect with Traci here: ⁠https://linktr.ee/HRTraci⁠Connect with Bryan: Website: https://bryanjdriscoll.com/ LinkedIn: https://www.linkedin.com/in/bryanjohndriscoll/ Disclaimer: Thoughts, opinions, and statements made on this podcast are not a reflection of the thoughts, opinions, and statements of the Company by whom Traci Chernoff is actively employed.Please note that this episode may contain paid endorsements and advertisements for products or services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

ADHD Experts Podcast
554- Are My Student's ADHD Accommodations in Danger? Fallout from the Department of Education Changes

ADHD Experts Podcast

Play Episode Listen Later May 14, 2025 60:38


Mary J. Goodwin-Oquendo, Esq., discusses how the dismantling of the U.S. Department of Education (DoE) may impact students with ADHD and learning disabilities who receive special education services and accommodations through IEPs and 504 Plans. ADHD Accommodations and Educational Rights: Additional Resources Free Download: Your Child's Legal Rights at School Read: “Is My Child's IEP in Danger?” Read: When Schools Resist Evaluating & Addressing Learning Disabilities eBook: The Complete IEP/504 Guide Access the video and slides for podcast episode #554 here: https://www.additudemag.com/webinar/adhd-accommodations-department-of-education-iep-504/ Thank you for listening to ADDitude's ADHD Experts podcast. Please consider subscribing to the magazine (additu.de/subscribe) to support our mission of providing ADHD education and support.

LSAT Unplugged
You Could LOSE Your LSAT Accommodations in 2025—Unless You Do This

LSAT Unplugged

Play Episode Listen Later May 14, 2025 5:21


The Bobber
Plan Your Mini-cation in the Town of BrookfieldPlan Your Mini-cation in the Town of Brookfield

The Bobber

Play Episode Listen Later May 9, 2025 11:41


In this episode, Hailey ventures to the beautiful and exciting Town of Brookfield, nestled on the outskirts of Milwaukee. This little town has become the shopping center of the area with the Corners of Brookfield right in the heart! Not only that, but the Town of Brookfield has many activities, events, and plenty of foodie options to check out while you're in the area. Let's dive into how you can plan your next Wisconsin mini-cation in the Town of Brookfield!The Bobber is brought to you by Something Special from Wisconsin: https://www.somethingspecialwi.com/Read the blog here: https://discoverwisconsin.com/plan-your-mini-cation-in-the-town-of-brookfield/The Corners of Brookfield: https://thecornersofbrookfield.com/; Twigs: https://shoptwigs.com/; Silverspot Cinema: https://silverspot.net/town-of-brookfield; Cafe Hollander: https://cafehollander.com/; Belair Cantina: https://belaircantina.com/; Fresh Fin Poke: https://www.freshfinpoke.com/; Indulgence Chocolatiers: https://indulgencechocolatiers.com/; Town Food Truck Festival: https://discoverbrookfield.com/events/town-food-truck-festival/; Hotels: https://discoverbrookfield.com/stay/; Mimosa: https://www.mimosabreakfast.com/menuThe Bobber: https://discoverwisconsin.com/the-bobber-blog/The Cabin Podcast: https://the-cabin.simplecast.com. Follow on social @thecabinpodShop Discover Wisconsin: shop.discoverwisconsin.com. Follow on social @shopdiscoverwisconsinDiscover Wisconsin: https://discoverwisconsin.com/. Follow on social @discoverwisconsinDiscover Mediaworks: https://discovermediaworks.com/. Follow on social @discovermediaworksTown of Brookfield: https://townofbrookfield.com/

Vacation Mavens
How to Plan Your First Trip to Hawaii (with an expert!)

Vacation Mavens

Play Episode Listen Later May 6, 2025 27:38


If Hawai'i is on your bucket list, you need to listen to this episode with Hawaii travel expert Marcie Cheung. Marcie is a family travel blogger and mom of two who's been to Hawaii more than 40 times, staying everywhere from luxury resorts to budget-friendly condos. She helps parents plan unforgettable Hawaii vacations with kids by sharing expert tips, honest reviews, and stress-free itineraries. You can learn more on her website hawaiitravelwithkids.com or follow Marcie on Facebook and Instagram. You can also listen to her podcast, Hawaii Travel Made Easy. Episode Highlights: The most popular tourist islands are: Oahu, Maui, Kauai, and Hawaii (The Big Island) Oahu is best if you can only visit one island and are looking for a mix of experiences and attractions from Pearl Harbor to the Dole Plantation and also city life, nightlife and beaches on the North Shore or Waikiki Maui is also popular for luxury resorts, a quieter vacation, the famous Road to Hana, and also great restaurants and activities Kauai is even more laid back The Big Island is good for those that are looking to be adventurous and take road trips, plus this is where you will find Volcanoes National Park A first time visitor coming from the U.S. should look at least one week and spend it on Oahu because it has such a range of experiences. If you have two weeks, then you can island hop from Oahu to Maui or Kauai. Be active on Oahu and then relax on Maui or Kauai. Keep in mind that when you island hop you still need to fly and deal with all of the airport security, rental car lines, etc. that eats up a lot of a day in travel. The Big Island is really large and you need at least five to seven days. It takes several hours to drive from the beach area to the Hawaii Volcanoes National Park. Expect to spend about $12,000 or more for a family vacation to Hawaii. Airfare from the West Coast is about $500 and closer to $900 from the East Coast. You can use a Southwest Companion Pass or Alaska Companion Pass if you have them. Accommodations keep getting more and more expensive. Midrange hotels are $350-500 and luxury resorts can easily go over $1000 per night. You need to beware about vacation rentals because they are being closely regulated in Honolulu and often they will be cancelled last minute as there are a lot of illegal vacation rentals. If you go with a vacation rental, go with something reputable. Food is also expensive because so much needs to be shipped in on the islands. Plan on spending about $100 a day on food if you are able to mix up going to restaurants and buying groceries or eating at food trucks. Rental car prices are high and you need a rental car for at least a few days on each island. Keep in mind that hotel parking can be $40-60 per night. Activities are also quite pricey, at $300-500 per person. Luaus are at least $200-350 per person. Narrow down your wish list to 2-3 activities and have beach or pool days or exploring on your own for the rest of the time. Minimum stays during winter break can be 7-14 days and this is the most expensive time to visit. When planning road trips or hikes, be sure to map them out to see how far they are and how long it will take to get there. Don't overpack your itinerary. Related Episodes: Insider tips for visiting the Disney Aulani Planning a Hawaiian vacation

Hawaii's Best - Guide to Travel Tips, Vacation, and Local Business in Hawaii
Best Time to Visit Hawaii for Families: Low Prices and Quiet Beaches (+ 3 Weeks to Skip)

Hawaii's Best - Guide to Travel Tips, Vacation, and Local Business in Hawaii

Play Episode Listen Later May 5, 2025 16:09 Transcription Available


Did you know picking the wrong week for your family's Hawaii vacation could double your costs and leave you battling crowds?If you've ever been frustrated by packed beaches or wondered why some trips seem so much smoother—and more affordable—than others, this episode is for you. Get the practical tips on how timing your trip to Hawaii can turn a stressful getaway into a relaxing adventure.In this episode of our travel podcast, we break down exactly when to visit Hawaii for the lowest prices and quietest beaches, and share which three weeks families should skip to avoid crowds and high costs.

Rick Steves' Europe Video
Choosing Accommodations - Rick Steves' Europe Travel Guide

Rick Steves' Europe Video

Play Episode Listen Later May 2, 2025 4:29


See your choice of a room or bed as part of the experience. Save money and maximize the memories by knowing your options. Watch the full talk at https://www.ricksteves.com/watch-read-listen/video/tv-show/experiencing-europe For European travel information, visit https://www.ricksteves.com.

Rick Steves' Europe Video
Choosing Accommodations - Rick Steves' Europe Travel Guide

Rick Steves' Europe Video

Play Episode Listen Later May 2, 2025 4:29


See your choice of a room or bed as part of the experience. Save money and maximize the memories by knowing your options. Watch the full talk at https://www.ricksteves.com/watch-read-listen/video/tv-show/experiencing-europe For European travel information, visit https://www.ricksteves.com.

Employee Survival Guide
S6 Ep124: Dr. Carrie Cunningham's Story: When Healers Need Healing

Employee Survival Guide

Play Episode Listen Later May 1, 2025 13:56 Transcription Available


Comment on the Show by Sending Mark a Text Message.This episode is part of my initiative to provide access to important court decisions  impacting employees in an easy to understand conversational format using AI.  The speakers in the episode are AI generated and frankly sound great to listen to.  Enjoy!Beneath the sterile drapes and surgical masks lies a devastating truth: surgeons have the highest suicide rate among all physicians. A staggering 15% report having contemplated ending their lives at some point in their careers, with 6% having such thoughts within just a single year.The juxtaposition is jarring – these talented professionals represent the pinnacle of medical achievement, yet many battle profound personal demons in silence. Through Dr. Carrie Cunningham's courageous presidential address to the Association for Academic Surgery, we witness this paradox firsthand. Despite her Harvard professorship, research grants, and leadership positions, she openly shared her struggles with depression, anxiety, and substance use disorder. Her vulnerability challenges our assumptions that external success guarantees internal well-being.The factors driving this crisis run deep. Medical training itself plants the seeds, with studies showing one-third of interns develop clinical depression. The surgical culture's emphasis on perfectionism, combined with sleep deprivation and high-stakes decision-making, creates tremendous pressure. Add to this the startling revelation that 45% of physicians experienced serious trauma before even entering medicine, and we begin to understand the perfect storm threatening our healers.Most concerning is the pervasive fear preventing surgeons from seeking help. Many go to extraordinary lengths – paying cash for therapy, traveling to distant cities for treatment, self-medicating – all to avoid potential career repercussions. Physician Health Programs exist in every state with impressive 90% success rates, yet many doctors don't know about these resources until they're in crisis.True progress requires fundamental shifts: moving beyond superficial "wellness" initiatives to address genuine mental health conditions, fostering cultures where vulnerability is seen as strength rather than weakness, and creating environments where seeking help doesn't jeopardize careers. The Dr. Lorna Breen Act represents a step forward, named for an emergency physician who died by suicide after working on the pandemic frontlines.Have you noticed signs of struggle in a colleague or friend? Reaching out could save a life. What small step might you take today to create a more supportive environment for those battling silently around you?National Suicide Prevention Lifeline If you enjoyed this episode of the Employee Survival Guide please like us on Facebook, Twitter and LinkedIn. We would really appreciate if you could leave a review of this podcast on your favorite podcast player such as Apple Podcasts. Leaving a review will inform other listeners you found the content on this podcast is important in the area of employment law in the United States. For more information, please contact our employment attorneys at Carey & Associates, P.C. at 203-255-4150, www.capclaw.com.Disclaimer: For educational use only, not intended to be legal advice.

The Bobber
Lake Geneva: A Hotspot for the Golf Enthusiast

The Bobber

Play Episode Listen Later Apr 30, 2025 11:56


In this episode, Hailey visits Lake Geneva, home to some of the best all-around golf courses in the state, and she's spilling all the inside details on the must-play courses in the area. Each course is home to its own style, unique layout, and beautiful views! Now… let's get into six different golf courses in the Lake Geneva area that you need to add to your golf bucket list!The Bobber is brought to you by Something Special from Wisconsin: https://www.somethingspecialwi.com/Read the blog here: https://discoverwisconsin.com/lake-geneva-a-hotspot-for-the-golf-enthusiast/Grand Geneva Resort: https://www.grandgeneva.com/golf; The Brute & The Highlands: https://www.grandgeneva.com/golf/courses; Accommodations: https://www.grandgeneva.com/main-lodge; Geneva Chophouse: https://www.grandgeneva.com/restaurants/geneva-chophouse; Links Bar & Grill: https://www.grandgeneva.com/restaurants/links-bar-grill; Cafes & Lounges: https://www.grandgeneva.com/bars-and-lounges; Geneva National Resort & Club: https://www.destinationgn.com/; Arnold Palmer Course: https://www.destinationgn.com/arnold-palmer-course; Gary Player Course: https://www.destinationgn.com/gary-player-course; Lee Trevino Course: https://www.destinationgn.com/lee-trevino-course; Accommodations: https://www.destinationgn.com/stay; Dining: https://www.destinationgn.com/dine; Lake Lawn Resort: https://www.lakelawnresort.com/golf/; Evergreen County Club: https://www.evergreengolf.com/; The Pub: https://www.evergreengolf.com/the-pub; Hawk's View Golf Club: https://www.hawksviewgolfclub.com/; Tail Feathers: https://www.hawksviewgolfclub.com/club/tail-feathers; Abbey Springs: https://www.abbeysprings.org/The Bobber: https://discoverwisconsin.com/the-bobber-blog/The Cabin Podcast: https://the-cabin.simplecast.com. Follow on social @thecabinpodShop Discover Wisconsin: shop.discoverwisconsin.com. Follow on social @shopdiscoverwisconsinDiscover Wisconsin: https://discoverwisconsin.com/. Follow on social @discoverwisconsinDiscover Mediaworks: https://discovermediaworks.com/. Follow on social @discovermediaworksVisit Lake Geneva: https://www.visitlakegeneva.com/. Follow on social @visitlakegeneva

At Peace Parentsâ„¢ Podcast
Ep. 110 - Speech Dude and I Talk School Accommodations for PDA Children and Teens

At Peace Parentsâ„¢ Podcast

Play Episode Listen Later Apr 29, 2025 73:22


In this episode I spoke with Chris Wegner - AKA "Speech Dude" - a speech language pathologist with extensive experience accommodating PDA teens in a public school. I loved our conversation, and I hope you will too!We talked about:Practical ways to communicate about PDA in a public school setting (in this case a high school).How to write PDA-specific goals/supports in an IEP (Institutional Educational Plan here in the United States).Supporting PDA teens to feel safe, engage in learning, and make social connections in creative ways that don't feel demanding.The role that autonomy plays in PDA teens' success.Here is more about Chris!Chris Wenger is a neurodivergent high school speech-language pathologist of over 20 years, international speaker, and creator of the Dynamic Assessment of Social Emotional Learning, a strengths-based assessment for autistic students. He is also the founder of NeuroAffirm, a first-of-its-kind worldwide interactive directory connecting providers and families. Globally known as Speech Dude, he has amassed nearly one million social media followers, sharing inspiring and educational content, always with a humorous twist.Mentioned in this episode:Paradigm Shift ProgramWant me to coach you as you learn and practice the skills and mindsets I talk about in my podcast? I'd love to work with you in my proven-effective Paradigm Shift Program. Click the link to learn more and join the program interest list. Paradigm Shift Program

AuDHD Flourishing
95 Kind Accommodations for Students & Teachers with Anna Shaver

AuDHD Flourishing

Play Episode Listen Later Apr 19, 2025 52:10


Anna is an educator who has developed an incredible approach with accommodations at the core (for the student AND herself!). It makes sense pedagogically, and it's working! With a core of psychological safety, students are able to explore writing and language with their own goals in mind.We've also known each other since I was 15... so we talk a bit about the mysterious backstory of living in a Christian sorority ;)Resources Anna mentioned:Workshopping: Liz Lerman's Critical Response ProcessAll My Relations podcastLove Your Brain course info & live round updateResources:Transcript DocEmail Newsletter: Nothing Wrong With UsLike Your Brain community space (Patreon) Hosted on Acast. See acast.com/privacy for more information.

KPFA - Pushing Limits
Housing Accommodations, Discrimination, & Action – Pushing Limits – April 18, 2025

KPFA - Pushing Limits

Play Episode Listen Later Apr 18, 2025 29:58


Struggling to get your landlord to install a ramp or let you keep a service animal? Ever been denied housing because of your disability, but weren't sure what to do next? You're not alone and there are protections in place. Angie Watson-Hajjem This week, Pushing Limits welcomes Angie Watson-Hajjem. She is the Fair Housing Coordinator of ECHO Fair Housing, which serves the San Francisco East Bay. Topics she will talk about include different forms of discrimination against people with disabilities, accommodations, recourse when discrimination occurs, plus the possible effects of Trump's actions on the disabled community. As the Fair Housing Coordinator, Angie investigates housing discrimination complaints for residents in Alameda, Contra Costa, and Monterey County. She is a certified mediator and helps facilitate reasonable accommodation requests for disabled tenants. Angie holds monthly regional fair housing trainings online where tenants and housing providers can receive fair housing education and counseling. This program is produced and hosted by Eddie Ytuarte. The post Housing Accommodations, Discrimination, & Action – Pushing Limits – April 18, 2025 appeared first on KPFA.

Play Big Faster Podcast
#194: Building Business Success Through Accessibility and Disability Inclusion | Angela Fowler

Play Big Faster Podcast

Play Episode Listen Later Apr 17, 2025 15:00


Struggling to make your business more inclusive? In this episode of Play Big Faster, accessibility expert Angela Fowler reveals how businesses can tap into the $2.1 trillion buying power of people with disabilities.  Angela shares her unique perspective as a blind business owner who focuses on opportunity rather than compliance. You'll learn: how designing for accessibility creates better experiences for everyone, simple cost-effective solutions to implement immediately, and why 25% of Americans have some form of disability—many invisible. Perfect for entrepreneurs seeking untapped market opportunities.  Angela's coaching approach transforms business mindsets instead of just fixing technical issues, building lasting accessibility practices that boost customer loyalty and reduce cart abandonment. Listen now to unlock profitable inclusion strategies that benefit all customers.

Nine To Thrive HR
Inside the 2025 Leave and Accommodations Report: HR's Role in the Employee Experience

Nine To Thrive HR

Play Episode Listen Later Apr 14, 2025 25:47


In this episode of Nine to Thrive HR, host Cindi Koetzle is joined by Seth Turner, Founder and Senior Advisor at AbsenceSoft, to explore the growing complexities of leave and accommodation in the workplace. They break down the biggest insights from our 2025 State of Leave and Accommodations Report, based on a survey of 2,400 employees and HR managers. Leave requests are rising, increased demand for mental health support is a growing factor, and compliance remains a challenge—so what does this mean for HR? We'll share findings leading to why leave and accommodations requests are increasing, how employers can balance compliance with employee support, and the biggest FMLA mistakes to avoid. Plus, we'll explore the importance of manager training and how technology can streamline processes while preserving a positive employee experience.

ACB Community
20250412 Handy Around the House - Housing Rights and Accommodations

ACB Community

Play Episode Listen Later Apr 12, 2025 42:35


20250412 Handy Around the House - Housing Rights and Accommodations Originally Broadcasted April 12, 2025, on ACB Media 5   This month, we explored housing rights and accommodations in different living situations—renting, owning a condominium or townhome, and dealing with Homeowners Associations (HOAs). A speaker from the Disability Rights Education and Defense Fund (DREDF) guided us through what you can request and what your rights are.   Find out more at https://acb-community.pinecast.co

rights housing handy accommodations around the house disability rights education acb media
Are they 18 yet?â„¢
Goals and Accommodations for Executive Functioning

Are they 18 yet?â„¢

Play Episode Listen Later Apr 9, 2025 34:25


In this episode, we dive into the often-overlooked art of writing clear, measurable goals for executive functioning. Unlike other academic or functional goals, executive functioning focuses on internal processes—making it harder to quantify and observe. Whether you're a teacher, therapist, or part of a school team, this episode will give you actionable tools to create meaningful IEP and therapy plan goals that truly support student growth.What You'll Learn in This Episode:✔️ Why executive functioning is all about the process—and why that's tricky for traditional SMART goals.✔️ Examples of goal formats that keep things simple, specific, and actionable.✔️ How to differentiate between goals that focus on behavior versus those emphasizing strategies.✔️ A sample list of accommodations to support executive functioning without over-accommodating.✔️ Tips to ensure students build independence with their accommodations over time.

Tomi Lahren is Fearless
House Moms Asking for Special Accommodations Sets Women Back 50 Years!

Tomi Lahren is Fearless

Play Episode Listen Later Apr 9, 2025 41:36


Tomi Lahren sounds off on the proxy voting battle in the House. "The Grace Curley Show" Host, Grace Curley, takes that on, MAGA raging against Justice Barrett, Elon Musk turning on tariffs, and more. Then, Trump plans to fine migrants $998 a day if they fail to leave after being given a deportation order and Tomi has some Final Thoughts. Learn more about your ad choices. Visit podcastchoices.com/adchoices

We Get Work
Mental Health Accommodations in the Workplace

We Get Work

Play Episode Listen Later Apr 8, 2025 18:53 Transcription Available


Accommodation requests for mental health issues are on the rise. Even though these types of disabilities might not be outwardly apparent, employers must address requests for mental health accommodations in the same way they would evaluate— and potentially accommodate—any disability as legally required. Chapters 00:00 Introduction to Mental Health Accommodations 03:08 The Interactive Process in Mental Health Accommodations 06:00 Challenges in Recognizing Mental Health Disabilities 08:53 The Role of Service Animals in the Workplace 12:12 Customizing the Interactive Process 15:11 Conclusion and Key Takeaways

Saturday Morning with Jack Tame
Mike Yardley: Spirit of Zurich

Saturday Morning with Jack Tame

Play Episode Listen Later Apr 5, 2025 7:47 Transcription Available


The great Swiss city of Zurich is one of the more picturesque, pixel-burning European gateway destinations. Within minutes of exiting Zurich Airport, armed with my trusty Eurail Pass, I was blissfully whizzing into the city centre on a 10 minute train ride. Strolling across the cobbles of this time-honoured city in the crisp spring air, there's so much urban eye-candy to lift the spirit. I sized up the largest clock face in Europe, on the edge of the Limmat River. It's bigger than Big Ben. Riding the skyline, the historic tower of St Peter Church is imbued with a trusty timepiece, as are the oh-so punctual church bells that loudly reverberate across the Old Town from the four historic churches, including mighty Grossmunster Cathedral. No wonder everything runs to time in Switzerland. According to legend, Zurich's 13th-century landmark cathedral was founded by Charlemagne, built on the graves of the city's patron saints, Felix and Regula. It was also the starting place of the Protestant Reformation in Zurich. Culture is writ large in Zurich's Old Town, where the narrow-cobbled streets gave rise to the Dada art movement just over a century ago. I popped into Cabaret Voltaire, at Spiegelgasse 1, which was the birthplace of Dada and the avant-garde artistic movement in 1916. Absinthe is the drink of choice here, among Dada's ghosts. Strolling along Bahnhofstrasse, flanked by chic designer boutiques and swanky department stores, Café Sprungli deserves a pit-stop. This prized Zurich institution is rightly lauded for its heavenly macaroons and hand-crafted chocolates. They are like exquisite works of art – as were the Easter chocolate displays. It's like a bespoke art gallery in chocolate. Don't mind if I do. Further down the street, if feeling a little decadent, make a date with Teuscher for its famed champagne truffles. In a city of water and stone bridges, a top vantage point to survey the elemental landscape, above the twisting lanes of the Old Town, is the Lindenhof. This was the site of a former Roman customs house and fourth-century fort, perched above the water. Alongside soaking up the city vistas, this elevated park with its Linden trees and giant chess sets is the pitch-perfect spot for a cheeky picnic. The vast assortment of guildhalls is core to Zurich's backstory, and they're great fun to explore. In 1336, Zurich's first independent mayor, Rudolf Brun, established the guild laws, effectively shifting power from the abbeys to the merchant nobility. The handsome guildhalls, with all their intricate decorative features, lend themselves to a leisurely inspection. I started at the bakers' guild, in Oberdorfstrasse, before heading over the river's east bank to Niederdorf, to admire the guilds of the carpenters, builders, the food and wine dealers, the textiles and spice merchants, all along Limmatquai. Then, on Munsterhof, you've got mansions of the weavers, saddlemakers, painters and winemakers. In German-speaking Zurich, the street food tradition of wurst remains wildly popular – particularly for lunch. In the Old Town, tuck into some great sausage at Wursteria by Hinz and Kunz. This part-butcher shop and part deli serves up super spicy bratwurst in a fluffy bun. So good! As its name suggests, Cafe Conditorei 1842, on Napfgasse, is an old-school establishment, chock-full of sweet indulgence. Spanning four floors, food lovers can enjoy patisserie, cakes and hot drinking chocolate – they claim to be Zurich's best. On the ground floor of this historic confectioner's store, impressively decorated in neo-baroque style, you'll struggle to find a finer array of patisserie, cakes and tarts. I could have stayed there all day. And yes – the steaming mug of hot chocolate with whipped cream was magnificent. Speaking of chocolate, the Lindt and Sprungli factory has called Zurich home, since 1899. Seven years in the making, Lindt Home of Chocolate, was designed to complement the historic building and serve as a beacon to chocolate lovers everywhere. From cultivation to production, the interactive museum does a sterling job telling the story of Swiss chocolate making, not only about Lindt, but its predecessors. While the maze of white, milk, and dark chocolates is impressive, the Lindt Home of Chocolate also boasts another record: the world's largest chocolate fountain. Standing at about 30 feet tall, even Willy Wonka would be impressed by this show-stopper. Zurich is home to FIFA's world headquarters and in a bid to stop pesky football fans from loitering in the lobby, the FIFA Museum was created nine years ago, in the heart of town. Spread over three floors and loaded with interactive exhibitions, the FIFA Museum examines all aspects of the global game and how it passionately stirs people's emotions. Football is the great equaliser. Along with the original FIFA World Cup Trophy, the museum displays over 1,000 items of exclusive memorabilia and apparel, including the national shirts of all FIFA member associations. The original trophy, which features a gold statuette of Nike, the Greek goddess of victory, holding a cup, was permanently awarded to Brazil after they won the cup for the third time, in 1970. The current trophy contains 5kg of pure gold and its estimated value is over NZ$30m. A highlight amongst the interactive games gallery is the gigantic pinball machine, where you can test your own ball kicking skills. With the next World Cup just a year away and featuring the All Whites for just the third time, add this museum to your check-list. Creating quite a buzz in recent years, Zurich-West has been spectacularly transformed from a once scruffy industrial district. Emerging as a vibrant cultural quarter of trendy eateries and edgy art, factories have been repurposed as theatres and shipyards reimagined as art galleries. Viadukt is an exemplary example of the makeover, with a host of eateries, pop-up shops and art spaces housed inside the arches of the disused, 550-feet long railway viaduct. You'll also find Prime Tower here, a 35-storey skyscraper (Switzerland's tallest), serving up a panoramic treat across Zurich's rooftops, gleaming lake and snow-coated peaks beyond. Take in the sweeping scenery over a drink or two at Clouds Bar – and salute your return to Europe. The locals are very proud of the city's brilliant and bizarre festivals. In August Zurich hosts Street Parade, one of Europe's biggest celebrations of peace, love and electronic music, attended by millions of people. In a couple of weeks, the city grinds to a halt for Seschselauten. This annual April spectacle involves setting on fire a giant straw snowman called the Boogg. The time it takes for the Boogg's head to explode indicates whether it will be a good summer, apparently. The word is Zurich is in for a long, warm summer. Perfectly poised overlooking Paradeplatz, the city's most prestigious address, the Mandarin Oriental Savoy Hotel offers a stylish stay to remember, when in Zurich. Just steps from the city's iconic shopping sweep of Bahnhofstrasse, it's been just over a year since the Mandarin Oriental revitalised what has been Zurich's oldest grand hotel, reaching back to 1838. Elegantly and artfully refreshed, with a boutique hotel vibe, the 80 impeccably redesigned rooms and suites raise the bar on luxury and indulgence. There's four distinctive dining venues including the Michelin-starred Orsini, where the Italian fine dining experience is helmed by acclaimed two-Michelin starred Italian Consultant Chef Antonio Guida. Then there's 1838, the effervescent rooftop bar with its spell-binding panoramic vistas of the city, lake and serrated Swiss Alps. Plus Savoy Brasserie & Bar is a sure-bet for a stupendous breakfast, with an delightfully presented buffet selection, in addition to a la carte menu items. Accommodations take their design cues from the natural palette of Zurich, headlined by the artisanal hand-painted silk wallpapers, inspired by the aqua green and blue hues of the lake and sky, to the mist of the surrounding mountains. Meticulously crafted design elements and materials adorn the rooms. Accents of colour are also reflected in custom furniture and carpets. Principal materials include walnut as a common thread, touches of bronze and brass and enamelled lava together with the comfort of luxurious textiles. Throughout the hotel, I loved admiring the multitude of sculptural lighting fixtures and lamps. I stayed in the Munsterhof Suite, accentuating the sumptuous sense of comfort, glamour and space, loaded with indulgent touches. There's a personal cocktail bar, built-in headboards, sublime marble-clad bathrooms and expansive walk-in dressing areas. As is the case with all Mandarin Oriental properties, you'll soon get a sense of the strong local connection the hotel has with the city. Local artists are proudly showcased with numerous pieces of art to admire, throughout the hotel. Grab a peek at the storied meeting room on the second floor, which is still home to the Guild of Tanners and Shoemakers. These traditional Swiss craftsmen have been meeting here for over a century. Service personifies whip-smart Swiss efficiency and the charismatic staff are highly personable, outgoing and engaging. You'll struggle to find fault with this gorgeous hotel which has mastered the art of fusing contemporary comforts with timeless opulence and celebrating a deep respect for history, tradition and proud sense of place. www.mandarinoriental.com Grab a ticket to ride on the European railway network with a Eurail Pass. For over 65 years, Eurail Passes have enabled flexible borderless rail travel across Europe. 7000 Kiwis purchased such a pass last year, which gives you access to 30,000 destinations across 33 countries, allowing you to chart your own amazing rail adventure. On popular rail routes, it certainly pays to make a seat reservation in advance. Lock in your rail plans ahead of your trip, by booking tickets or a rail pass to suit with Eurail direct. The mobile pass is the way to go. The Eurail app is easy to navigate, packed with helpful information and benefits, network disruption notifications, and enabling you to check timetables, lock in bookings and seat reservations on the go, via your mobile. www.eurail.com Fly to Zurich with Cathay Pacific who operate ultra-contemporary A350-1000s, from Auckland via Hong Kong. The cabin air quality is decidedly better, the aircraft are noticeably quieter and I experienced minimal jet-lag. The extensive CX Entertainment system kept me suitably engaged with excellent movie and box-set selections, live news channels - all in vivid 4K, plus in-flight WiFi is available. www.cathaypacific.com Mike Yardley is our resident traveller and can be heard every Saturday with Jack Tame on Newstalk ZB. LISTEN ABOVE See omnystudio.com/listener for privacy information.

Attention Talk Radio
Navigating ADHD Accommodations for College Students

Attention Talk Radio

Play Episode Listen Later Apr 2, 2025 53:39


The framework of accommodations is evolving as more college students with both visible and invisible disabilities, including ADHD, seek the support they need. While the Americans with Disabilities Act provides a basis for these accommodations, the process of securing them can be complex, time consuming, and expensive.In this episode of Attention Talk Radio, Jeff Copper talks with Romaney Berson of B Focused Coaching, who has firsthand experience navigating the system. She shares valuable insights and practical tips to help parents and students advocate effectively and secure the right accommodations for academic success.If you have a high school or early college student with ADHD, this is an episode you won't want to miss!Attention Talk Radio is the leading site for self-help Internet radio shows focusing on attention deficit hyperactivity disorder and attention deficit disorder, including managing symptoms of ADHD in adults with ADD or adults who have children with ADHD. Attention Talk Radio, hosted by Jeff Copper, attention and ADHD coach, is designed to help adults (particularly those diagnosed with or impacted by attention deficit disorder or its symptoms) in life or business who are stuck, overwhelmed, or frustrated to help them get unstuck and moving forward by opening their minds to pay attention to what works. To learn more about attention and ADHD coach Jeff Copper, go to www.digcoaching.com. Our thanks to the sponsors of this show: CHADD.org, ADDCA.com, ImpactParents.com, and TimeTimer.com.

Coordinated
269. A Guide to Accommodations

Coordinated

Play Episode Listen Later Mar 31, 2025 9:56


Derek and Karli have struck gold with the all-new AP Accommodations Guide. No more searching for hidden gems – everything is now in one place. Press Play to set sail on a golden voyage. Discover the ultimate treasure, right now, on this episode of…Coordinated.Check out the 2024-25 AP Accommodations Guide.-----Watch the Coordinated podcast on YouTube.Subscribe to the AP Coordinator Experience YouTube Channel.Don't miss the Release Party, AP Coordinator's Manual, Part 2.Catch two all new videos… The Proctor Training Overview and Proctor Training Highlights.View the videos on AP Art and Design, AP Music Theory – Exam Administration, and AP Music Theory – Room Configurations and Best Practices.Be sure to check out videos about Students Accounts (for AP coordinators) and Student Accounts (to share with your AP students). Chat it up with fellow AP coordinators on Chat with a Coordinator.Bookmark the AP Coordinator Experience webpage.Watch this video series on how to use AP Registration and Ordering.Review dozens On-Demand videos created to help guide and support AP coordinators.Learn more about digital testing, including a series of helpful webinars.Join the AP Coordinator Community. Read up at the AP Coordinator Resource Library. Podcast theme song, “Good as Gold,” courtesy of former AP Music Theory student, Jackie Rae.

The James Altucher Show
"Nomadic Matt" Kepnes on Traveling the World for $75 a Day

The James Altucher Show

Play Episode Listen Later Mar 27, 2025 58:02


A Note from James:Is it possible to travel around the world, live around the world, do remote work anywhere you want, and spend just $75 a day or less? When I was younger, I wish I'd tried this. Back then, you probably could have done it for even less, maybe $30 a day! Today's guest, Matt Kepnes—better known as Nomadic Matt—has spent decades traveling the globe on a budget. Ten years ago, he wrote How to Travel the World on $50 a Day, and he's just updated it with How to Travel the World on $75 a Day or Less. It's definitely possible. I'm even sharing this episode with my daughters because there's a perception that travel is too expensive. Matt has tips on everything from finding cheap flights and accommodations to securing remote work opportunities. Travel opens your mind without the stress that comes with age and responsibility. If you travel cheaply, you'll not only have amazing experiences but also become more successful and open-minded. I wish I had traveled more when I was younger—I didn't think I could afford it, but as Matt explains, you certainly can.Episode Description:Matt Kepnes, aka Nomadic Matt, returns to discuss the realities of traveling the world cheaply in 2025. With inflation and changes since COVID-19 dramatically affecting costs, Matt explains how traveling on just $75 a day is not only possible but easier than you think. You'll learn practical tips for finding cheap flights, affordable accommodations, and even ways to make money while traveling. Matt also shares personal insights into how decades of constant travel impacted his life, friendships, and perspectives.What You'll Learn:How flexibility with travel dates and destinations can drastically reduce your expenses.Practical tips for securing international flights at a fraction of typical costs.Simple strategies for reducing daily living expenses abroad (accommodations, meals, transportation).Realistic job ideas and online resources to help you earn money while traveling.How long-term travel impacts relationships, personal growth, and life decisions.Chapters:[00:00] Introduction: Traveling the World on a Budget[02:00] The Impact of Inflation and COVID on Travel Costs[04:00] The Rise of the Digital Nomad Lifestyle[07:00] Money-Saving Travel Tips[08:00] Finding Cheap Flights and Accommodations[14:00] Living Cheaply in Different Countries[19:00] Matt's Journey: From Corporate Job to World Traveler[27:00] Making Money While Traveling[31:00] Easiest Job for Travelers[32:00] Journey to Becoming a Travel Writer[34:00] Advice for New Travelers[36:00] Favorite Travel Destinations[37:00] Impact of Sharing Economy on Travel[39:00] Challenges of Long-Term Travel[43:00] Global Perceptions of American Travelers[49:00] Why America Leads in Innovation[51:00] Top Countries to Move to in Europe[53:00] Resources for Aspiring Travelers[55:00] Conclusion and Final ThoughtsAdditional Resources:How to Travel the World on $75 a Day by Matt KepnesGoing.com (Flight Deals)Workaway.info (Work Exchange Opportunities)Blablacar (Ride Sharing)Travel Ladies App (For Female Travelers)Nomadic Matt's WebsiteDie with Zero by Bill PerkinsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Workplace Wake-Up with Jen Shaw
Yes…Leaves of Absence and Reasonable Accommodations AGAIN!

Workplace Wake-Up with Jen Shaw

Play Episode Listen Later Mar 26, 2025 16:40


In this episode, Jen provides some best practices for avoiding liability related to leaves of absence and reasonable accommodations.  

Aspire for More: How to be an Everyday Negotiator
Part 2: Negotiating WFH expectations | How do I negotiate disability accommodations at work?

Aspire for More: How to be an Everyday Negotiator

Play Episode Listen Later Mar 25, 2025 20:47


Performance evaluations can be a stressful and uncertain process, especially when unclear expectations and shifting company policies come into play.Many employees find themselves in situations where new workplace rules—such as in-office attendance requirements—suddenly become factors in their evaluations, leaving them unsure of how to advocate for themselves.What do you do when the criteria for promotions and raises seem ambiguous or unfair?This is part 2 of a 3-part series, and in this episode, we break down key aspects of Sylvia's case and explore negotiation strategies to ensure her hard work and contributions are recognized.In the second part of this episode, our listener question is: How do I navigate the complex process of requesting reasonable accommodations at work, especially when dealing with unclear legal territory, back-and-forth negotiations, and a hesitant HR department? Should I approach the situation collaboratively or take a firmer stance on my needs?—This podcast is a call-in show, so if you or a woman you know needs help in this area, feel free to contact me at joan@moonnegotiation.com to submit your questions or join me in our next episode. JOIN THE PRIORITY LIST FOR JOAN'S NEXT COHORT OF THE ADVANCED NEGOTIATION INTENSIVEhttps://course.moonnegotiation.com/Join-the-WaitlistCONNECT WITH JOAN:⚉ Website: https://www.moonnegotiation.com/ ⚉ LinkedIn: https://www.linkedin.com/in/joanmoon413/ ⚉ Instagram: https://www.instagram.com/moonnegotiation⚉ TikTok: https://www.tiktok.com/@moonnegotiationJOIN THE MAILING LIST FOR NEWS AND NEGOTIATION TIPS:https://www.moonnegotiation.com/social-media Send us a text

Focal Point Radio Broadcasts
Misunderstandings & Accommodations-Part C

Focal Point Radio Broadcasts

Play Episode Listen Later Mar 24, 2025 25:00


Today’s Broadcast March 24, 2025Misunderstandings & Accommodations-Part CActs 21:17-26 Listen Download Today's Message Purchase Message Download Worksheet From Series: A Painful Path Purchase Entire Series Broadcast Archive Message Description Strategic accommodations and biblically allowable personal adjustments will be necessary as we face the painful misunderstandings sure to continue among God's people, this side of heaven. Series Description God's plan for your life will undoubtedly include plenty of pain on this side of heaven. Often we can see the hard times ramping up amid a variety of worsening circumstances. In Acts 21 the Apostle Paul shows us how to face dark days with a godly intent and a reliance on the Lord each step of the way. Pastor Mike helps us learn how to walk closely with the Lord when the path is painful. Subscribe to PodcastApple PodcastsAndroidby EmailRSSThis Month’s ResourceReceive Monthly Insight from Pastor MikeSign up to receive Pastor Mike Fabarez’s Monthly Ministry Update in your inbox. Contact Permission By clicking the “Subscribe” button above, I am requesting to receive e-mail communications from Focal Point Ministries, and I agree to allow my personal data to be processed according to their Internet Privacy Policy. Share This Message:

Focal Point Radio Broadcasts
Misunderstandings & Accommodations-Part B

Focal Point Radio Broadcasts

Play Episode Listen Later Mar 20, 2025 25:00


Today’s Broadcast March 20, 2025Misunderstandings & Accommodations-Part BActs 21:17-26 Listen Download Today's Message Purchase Message Download Worksheet From Series: A Painful Path Purchase Entire Series Broadcast Archive Message Description Strategic accommodations and biblically allowable personal adjustments will be necessary as we face the painful misunderstandings sure to continue among God's people, this side of heaven. Series Description God's plan for your life will undoubtedly include plenty of pain on this side of heaven. Often we can see the hard times ramping up amid a variety of worsening circumstances. In Acts 21 the Apostle Paul shows us how to face dark days with a godly intent and a reliance on the Lord each step of the way. Pastor Mike helps us learn how to walk closely with the Lord when the path is painful. Subscribe to PodcastApple PodcastsAndroidby EmailRSSThis Month’s ResourceReceive Monthly Insight from Pastor MikeSign up to receive Pastor Mike Fabarez’s Monthly Ministry Update in your inbox. Contact Permission By clicking the “Subscribe” button above, I am requesting to receive e-mail communications from Focal Point Ministries, and I agree to allow my personal data to be processed according to their Internet Privacy Policy. Share This Message:

Focal Point Radio Broadcasts
Misunderstandings & Accommodations-Part A

Focal Point Radio Broadcasts

Play Episode Listen Later Mar 19, 2025 25:00


Today’s Broadcast March 19, 2025Misunderstandings & Accommodations-Part AActs 21:17-26 Listen Download Today's Message Purchase Message Download Worksheet From Series: A Painful Path Purchase Entire Series Broadcast Archive Message Description Strategic accommodations and biblically allowable personal adjustments will be necessary as we face the painful misunderstandings sure to continue among God's people, this side of heaven. Series Description God's plan for your life will undoubtedly include plenty of pain on this side of heaven. Often we can see the hard times ramping up amid a variety of worsening circumstances. In Acts 21 the Apostle Paul shows us how to face dark days with a godly intent and a reliance on the Lord each step of the way. Pastor Mike helps us learn how to walk closely with the Lord when the path is painful. Subscribe to PodcastApple PodcastsAndroidby EmailRSSThis Month’s ResourceReceive Monthly Insight from Pastor MikeSign up to receive Pastor Mike Fabarez’s Monthly Ministry Update in your inbox. Contact Permission By clicking the “Subscribe” button above, I am requesting to receive e-mail communications from Focal Point Ministries, and I agree to allow my personal data to be processed according to their Internet Privacy Policy. Share This Message:

The Art of Passive Income
How to be a Better Lender in Handling Loan Accommodations

The Art of Passive Income

Play Episode Listen Later Mar 18, 2025 20:39


Listen in as they discuss:Loan automations.Loan modification requests.Changing contracts for a fee. Upholding what was agreed upon. Mark also discussed the art of lending.  TIP OF THE WEEKLandon: Explore AppSumo to find cost-effective alternatives for essential business tools. This platform offers lifetime deals on various apps, helping entrepreneurs save on recurring software costs while enhancing their workflows. Check it out at appsumo.com. WANT TO LISTEN MORE?Did you like this episode? If so, listen to another AOPI episode to hear more about land investing tips that can help grow your land business."Are you ready to learn more about land investing? Just click HERE to schedule a call.""Isn't it time to create passive income so you can work where you want when you want, and with whomever you want?"

Were You Raised By Wolves?
Bailing on Bad Accommodations, Attending Virtual Housewarmings, Moving Meetings "Up," and More

Were You Raised By Wolves?

Play Episode Listen Later Mar 17, 2025 30:34


Etiquette, manners, and beyond! In this episode, Nick and Leah answer listener questions about bailing on bad accommodations, attending virtual housewarming parties, moving meetings "up," and much more. Please follow us! (We'd send you a hand-written thank you note if we could.) Have a question for us? Call or text (267) CALL-RBW or visit ask.wyrbw.com QUESTIONS FROM THE WILDERNESS: What is the proper etiquette when your deli order is more than you wanted? How to I bail as a houseguest when the accommodations aren't comfortable? Should I attend a "virtual" housewarming? How to I stop my mother-in-law from bringing over food that needs to be prepared in our kitchen? What does moving a meeting “up” or “back” mean? THINGS MENTIONED DURING THE SHOW Lining up at Costco YOU ARE CORDIALLY INVITED TO... Support our show through Patreon Subscribe and rate us 5 stars on Apple Podcasts Call, text, or email us your questions Follow us on Instagram, Facebook, and Twitter Visit our official website Sign up for our newsletter Buy some fabulous official merchandise CREDITS Hosts: Nick Leighton & Leah Bonnema Producer & Editor: Nick Leighton Theme Music: Rob Paravonian ADVERTISE ON OUR SHOW Click here for details TRANSCRIPT Episode 259 Learn more about your ad choices. Visit megaphone.fm/adchoices

kPod - The Kidd Kraddick Morning Show
Big Al's Accommodations

kPod - The Kidd Kraddick Morning Show

Play Episode Listen Later Mar 17, 2025 11:42


Big Al didn't get do a whole lot of research before booking his AirBNB. Learn more about your ad choices. Visit megaphone.fm/adchoices

McNeil & Parkins Show
Ryan Poles' draft board is wide open, Spiegs & Laurence learn that they share the same favorite MLB player & Chris Collins is mad about Northwestern's hotel accommodations (Hour 4)

McNeil & Parkins Show

Play Episode Listen Later Mar 14, 2025 21:54


Ryan Poles' draft board is wide open, Spiegs & Laurence learn that they share the same favorite MLB player & Chris Collins is mad about Northwestern's hotel accommodations (Hour 4) full 1314 Fri, 14 Mar 2025 23:01:50 +0000 kUwHnOxHuzJsiMYTDZM0NTN2PbKSxTeW sports Spiegel & Holmes Show sports Ryan Poles' draft board is wide open, Spiegs & Laurence learn that they share the same favorite MLB player & Chris Collins is mad about Northwestern's hotel accommodations (Hour 4) Matt Spiegel and Laurence Holmes bring you Chicago sports talk with great opinions, guests and fun. Join Spiegel and Holmes as they discuss the Bears, Blackhawks, Bulls, Cubs and White Sox and delve into the biggest sports storylines of the day. Recurring guests include Bears cornerback Jaylon Johnson, former Bears coach Dave Wannstedt, former Bears center Olin Kreutz, Cubs manager Craig Counsell, Cubs second baseman Nico Hoerner and MLB Network personality Jon Morosi. Catch the show live Monday through Friday (2 p.m. - 6 p.m. CT) on 670 The Score, the exclusive audio home of the Cubs and the Bulls, or on the Audacy app. 2024 © 2021 Audacy, Inc.

LSAT Unplugged
How LSAT Accommodations Can Skyrocket Your Score (What They Don't Tell You)

LSAT Unplugged

Play Episode Listen Later Mar 13, 2025 6:58


Veterinary Viewfinder Podcast
Mental Health in Vet Med: Accommodations Young Veterinary Professionals Need to Know

Veterinary Viewfinder Podcast

Play Episode Listen Later Mar 12, 2025 29:18


Dive into this week's episode of “The Veterinary Viewfinder” with hosts Dr. Ernie Ward and Beckie Mossor, MPA, RVT, as they tackle a pressing topic for young veterinary professionals: mental health accommodations in practice. In this episode, the duo explores how the Americans with Disabilities Act (ADA) applies to veterinary settings, offering practical insights for navigating stress and anxiety on the job.  Dr. Ward shares a real-world example of a young vet struggling with “difficult clients,” sparking a discussion on what “reasonable accommodations” look like—think flexible schedules or quiet decompression spaces.  Meanwhile, Beckie opens up about her husband's PTSD accommodation—an hour-late start that balances his needs with workplace demands—showing how creative solutions can work in high-pressure environments.  Together, they emphasize empathy, clear job descriptions, and proactive mental health support, urging young vets to advocate for themselves.  Whether you're a new associate or a vet tech facing burnout, this episode delivers actionable advice and a fresh perspective on thriving in vet med. Tune in to feel empowered, understood, and ready to shape a healthier workplace—because everyone's mental health matters! #mentalhealth #burnout #selfcare #wellness #veterinary #veterinarytechnician #vettech #veterinary #podcast #veterinarypodcast #vettechpodcast #vetpodcast #vetmed

LSAT Demon Daily
Accommodations According to Your Needs (Ep. 1066)

LSAT Demon Daily

Play Episode Listen Later Mar 12, 2025 6:12


There isn't an objective best when it comes to accommodations. They should be according to your individualized needs based on medical advice and your studying experience. Read more on our website. Email daily@lsatdemon.com with questions or comments. Watch this episode on Youtube!

The Autism Little Learners Podcast
#113 - Pathological Demand Avoidance (PDA) With Dr. Taylor Day

The Autism Little Learners Podcast

Play Episode Listen Later Mar 11, 2025 43:53


In today's episode, I'll be discussing Pathological Demand Avoidance (PDA) with Dr. Taylor Day.  The conversation explores the drive for autonomy in children with PDA, the impact of the fight or flight response, and effective strategies for supporting these children in educational and home settings. Dr. Tay advocates for a nuanced approach to parenting and teaching that respects children's autonomy while maintaining necessary boundaries. Buckle up, because you are going to learn so much today!   Bio: Dr. Taylor Day is a licensed psychologist specializing in neuroaffirming care for autistic children and their families, including very early diagnosis and early intervention. She has a Ph.D. in clinical psychology and is the CEO and founder of Dr. Tay Concierge Clinical Care.  Her practice integrates The Whole Family Approach, a process she created utilizing evidence-informed principles after seeing a gap in autism care. Her passion for child psychology and her focus on autism is in many ways tied to her own personal experience growing up with a brother who was diagnosed at 23 months of age.  Links: Dr. Tay's Instagram: https://www.instagram.com/the.dr.tay/ Dr. Tay's Website: https://drtaylorday.com Evolve Podcast: https://podcasts.apple.com/us/podcast/evolve-with-dr-tay-the-podcast-for-parents-of-autistic-kids/id1659784037  Takeaways  ●      PDA is not a well-defined diagnosis but a theorized profile of autism. ●      Understanding the nervous system's response is crucial in addressing PDA behaviors. ●      Children with PDA often seek autonomy and challenge authority. ●      Traditional parenting models may not work for children with PDA. ●      Collecting data on behaviors helps identify effective interventions. ●      Low demand approaches can be beneficial but must be balanced with boundaries. ●      Collaboration among adults is key to supporting children with PDA. ●      Recognizing the human behind the behavior fosters better relationships. ●      Teaching skills for autonomy is essential for long-term success. ●      Empowering children with choices enhances their learning experience. ●      Focusing on mastery over repetition can reduce stress for students. ●      Parents' insights about their children should be valued and respected. ●      The educational system needs to adapt to individual needs rather than enforcing rigid rules. ●      Connection and trust are fundamental in supporting children with challenging behaviors. You may also be interested in these supports: 1.    Visual Support Starter Set 2.    Visual Supports Facebook Group 3.    Autism Little Learners on Instagram 4.    Autism Little Learners on Facebook

ASCO Daily News
Emerging Therapies in Acute Myeloid Leukemia

ASCO Daily News

Play Episode Listen Later Mar 6, 2025 29:38


Dr. John Sweetenham and Dr. James Foran discuss the evolving treatment landscape in acute myeloid leukemia, including new targeted therapies, advances in immunotherapy, and the current role for allogeneic transplantation. TRANSCRIPT Dr. John Sweetenham: Hello, I'm Dr. John Sweetenham, the host of the ASCO Daily News Podcast. There has been steady progress in the therapies for acute myeloid leukemia (AML) in recent years, largely based on an increasing understanding of the molecular mechanisms which underlie the disease. On today's episode, we'll be discussing the evolving treatment landscape in AML. We'll explore risk group stratification, new targeted therapies, advances in immunotherapy for AML, and also a little about the current role for allogenic transplantation in this disease.  I'm delighted to welcome Dr. James Foran to this discussion. Dr. Foran is a professor of medicine and chair of the Myeloid Malignancies and Blood and Marrow Transplant Disease Group at the Mayo Clinic Comprehensive Cancer Center. He's based in Jacksonville, Florida.  Our full disclosures are available in the transcript of this episode.  James, it's great to have you join us on the podcast today, and thanks so much for being here. Dr. James Foran: I'm delighted and thank you for the invitation. Thank you very much. Dr. John Sweetenham: Sure, James, let's get right into it. So, our understanding of the molecular mechanisms underlying AML has resulted not only in new methods for risk stratification in this disease, which have added refinement to cytogenetics, but also has resulted in the development of many new targeted agents. Understanding that this is a complex area of investigation, and our time is somewhat limited, can you give us a high-level update on the current state of the art in terms of how risk factors are being used for treatment selection now? Dr. James Foran: Absolutely. I think in the past, you know, we had things broken down pretty simply into make a diagnosis based on morphology, do cytogenetics, break patients into the groups of those who were more likely to benefit from therapy – so-called favorable risk – those where the intensive therapies were less likely to work – so-called poor adverse risk, and then this large intermediate group that really had variable outcomes, some better, some worse. And for a long time, the progress was in just identifying new subtle cytogenetic risk groups. And then, late 1990s, we began to understand that FLT3 mutations or NRAS mutations may be more adverse than others that came along. In the first part of this millennium, in the, you know, 2000-2010 range, a lot of work was being done to understand better or worse risk factors with single genes. The ability to do multiplex PCR, and then more recently NGS platforms, have allowed us to really look at many genes and identify many mutations in patients. At the beginning that was used just to sort of refine – who did a little better, who did a little worse with intensive therapy – helped us decide who may benefit more from an allogeneic transplanter for whom that would not be necessary.  But the good news is that really, we're now starting to target those mutations. One of the first molecularly targeted treatments in leukemia was FLT3 mutations, where we knew they were adverse. Then along came targeted treatments. I was involved in some of those early studies looking at sunitinib, sorafenib, more recently midostaurin, now quizartinib, FDA approved, and gilteritinib in the relapse refractory setting.  So we're moving into a state where we're not just refining prognosis, we're identifying targets. You know, it's been slow progress, but definite incremental progress in terms of outcomes by looking for FLT3 mutations, then looking for IDH mutations, and more recently, mutations involving NPM1 or rearrangement of what we used to call the MLL gene, now the lysine methyltransferase 2A or KMT2A rearrangement, where we now have targets. And it's not just for refinement of prognosis, but now we're identifying therapeutic targets for patients and ways to even look for measurable residual disease which is impacting our care. Dr. John Sweetenham: That's great, James. And I'm going to expand on that theme just a little bit and perhaps ask you to elaborate a little bit more on how the introduction of these new therapies have specifically impacted frontline therapy. And a couple of ancillary questions maybe to go along with that: First of all, is ‘7+3' a standard therapy for anybody in 2025? And maybe secondly, you know, could you comment also maybe briefly on older patients with AML and how you think maybe the treatment landscape is changing for them compared with, say, 5 or 10 years ago? Dr. James Foran: I'll start with the therapy and then work my way back. So we've had ‘7+3' cytarabine daunorubicin or cytarabine anthracycline since 1976, and we're still using it as the backbone of our intensive therapy. There is still an important role for it, particularly in younger or fitter patients, and particularly for those with intermediate or favorable risk genetic groups or cytogenetic risk groups just because we achieve high rates of remission. Our 30-day induction mortality rates are lower now than they were 10 and 20 years ago. Our supportive care is better. And we still have a busy inpatient hospital service here at Mayo Florida and my colleagues in Rochester and Arizona as well giving intensive therapy. So that remains the backbone of curative therapy for younger adults. We are trying to be a little more discriminating about who we administer that to. We are trying to add targeted agents. We know from, now, two different randomized trials that the addition of a FLT3 inhibitor, either midostaurin or more recently quizartinib, has a survival advantage in patients with a FLT3 mutation, or for quizartinib, a FLT3/ITD mutation. And so yes, ‘7+3' remains important.  Off protocol for somebody who just comes in with acute leukemia in a 40-year-old or 30-year-old or even early 60s and fit, we would still be considering ‘7+3' therapy and then waiting for an expedited gene mutation panel and an expedited cytogenetics panel to come back to help us discriminate is that a patient for whom we should be giving a FLT3 inhibitor? I think there's a little more nuance about when we do a day 14 bone marrow, do they really matter as much anymore? I still do them. Some of my colleagues find them less important. But we're still giving intensive therapy. We're still giving high-dose ARA-C consolidation for younger patients who achieve complete remission.  In older adults, it's a different story. You know, it was only in the early part of the 2000s – 2004, 2007 range – where we really got buy-in from randomized studies that low-dose therapy was better than no therapy. There was a lot of nihilism before then about therapy for older adults, especially over age 75. We know that low-dose ARA-C is better than nothing. It looked like azacitidine was better than ARA-C or at least equivalent or slightly better. But with the advent of venetoclax it was a game changer. I ran a national randomized study of intensive therapy in AML. It was the last national randomized study of intensive therapy in older patients right before venetoclax got approved. And we were very excited about our results, and we thought we had some really interesting clinical results. And suddenly that's a little bit obsolete in patients over 70 and particularly over age 75 because of the high remission rates with azacytidine venetoclax or hypomethylating agents, so-called HMAs and venetoclax and the survival advantage. Now, it's not a home run for everybody. We quote 60% to 70% remission rates, but it's a little different based on your cytogenetics and your mutation profile. You have to continue on therapy so it's continuous treatment. It's not with curative intent, although there are some people with long-term remission in it. And the median survival went from 10 months to 15 months. So home run? No, but definitely improved remissions, meaningful for patients off transfusions and better survival. So right now it's hard to find an older adult who you wouldn't give azacitidine and venetoclax or something similar, decitabine, for instance, and venetoclax, unless somebody really was moribund or had very poor performance status or some reason not to. And so ‘7+3' is still relevant in younger adults. We're trying to get better results with ‘7+3' by adding targeted agents and azacitine and venetoclax in older adults.  I think the area of controversy, I guess there are two of them, is what to do in that overlap age between 60 and 75. Should people in that age still get intensive therapy, which we've used for years – the VIALE-A trial of aza-venetoclax was age 75 plus – or with cardiac comorbidities? And I think if you're 68 or 72, many of us are starting to bias towards aza-venetoclax as generally being better tolerated, generally being more outpatient, generally being slow and steady way to get a remission. And it doesn't stop you from going to transplant for somebody who might still be a candidate.  The other area of controversy is somebody under 60 who has adverse cytogenetics where we don't do very well with ‘7+3,' we still give it and we might do just as well with decitabine venetoclax. A lot of us feel that there's equipoise in the 60 to 75 group where we really can ask a question of a randomized study. Retrospective studies might suggest that intensive therapy is a little better, but there are now a couple of randomized studies happening saying, “Can we replace ‘7+3' in that intermediate age with aza-venetoclax?” And for younger adults similarly, we're looking to see how we apply that technology. Those are the areas where we're really trying to investigate what's optimal for patients and that's going to require randomized trials. Dr. John Sweetenham: Oh, that's great, thank you. And I'll just extend that question a little bit more, particularly with respect to the new targeted therapies. How much are they impacting the treatment of these patients in the relapse and refractory setting now? Dr. James Foran: Oh, they're definitely impacting it. When I trained and probably when you trained, AML was still a medical emergency. But that was the thing that you admitted to the hospital immediately, you started therapy immediately. The rule was always that's the one thing that brings the fellow and the consultant in at night to see that new patient on a Friday or Saturday. Now, we'll still admit a patient for monitoring, but we try not to start therapy for the first three or five or seven days if they're stable, until we get those genetics and those genomics back, because it helps us discriminate what therapy to pursue. And certainly, with FLT3 mutations, especially FLT3/ITD mutations, we're adding FLT3 inhibitors and we're seeing a survival advantage. Now, on the surface, that survival advantage is in the range of 7% or 10%. But if you then pursue an allogeneic transplant in first remission, you're taking disease where we used to see 30%, 40% long-term survival, maybe less, and you're pushing that to 60%, 70% in some studies. And so we're now taking a disease that– I don't want to get off topic and talk about Ph+ ALL. But that's a disease where we're actually a little excited. We have a target now, and it used to be something really adverse and now we can do a lot for it and a lot about it.  The other mutations, it's a little more subtle. Now, who knew until 2010 that a mutation in a sugar metabolism gene, in isocitrate dehydrogenase, or IDH was going to be so important, or even that it existed. We know that IDH1 and IDH2 mutations are still a minority of AML, certainly less than 10% to 15%, maybe overall. But we're able to target those with specific IDH1 and IDH2 inhibitors. We get single-agent responses. There are now two approved IDH1 inhibitors on the market. We don't yet have the randomized data that adding those to intensive therapy is better, but we're getting a very strong hint that it might be better in older adults who have an IDH mutation, maybe adding those is helpful and maybe adding those to low-intensity therapy is helpful. Those studies are ongoing, and we're also trying with low-intensity treatments to add these agents and get higher remission rates, deeper remissions, longer remissions. I think a lot of work has to be done to delineate the safety of that and the long-term efficacy. But we're getting hints it's better, so I think it is impacting.  The other area it's impacting is when you pick up adverse mutations and those have crept into our classification systems like an ASXL1 mutation or RUNX1 mutation for instance, or some of the secondary AML mutations like BCOR and others, where that's helping us discriminate intermediate-risk patients who we think aren't going to do as well and really helping us select a group who's more likely to get benefit from allogeneic transplant or for whom at least our cure rates without allo transplant are low. And so I think it's impacting a lot. Dr. John Sweetenham: Great. And I'm going to pick up now, if I may, on a couple of things that you've just mentioned and continue the theme of the relapsed and refractory setting. We've started to see some reports which have looked at the role of immune strategies for patients with AML, in particular CAR T or NK cells. Can you comment a little on this and let us know whether you think either these two strategies or other immune strategies are likely to have a significant role in AML in the future? Dr. James Foran: They are, but I think we're still a step behind finding the right target or the right way to do it. If you think of allogeneic transplantation as the definitive immune therapy, and we know for adverse AML we can improve survival rates and cure rates with an allotransplant, then we know inherently that immune therapy matters. And so how do we do what they've done in large cell lymphoma or in CD19 targeting for B cell malignancies? How do we bring that to acute myeloid leukemia? There have been a number of efforts. There have been at least 50 trials looking at different targets. CD33, CD123, CD7, others, CLL-1. So, there have been a number of different trials looking at how to bind a CAR T or a CAR T construct that can be active. And we have hints of efficacy. There was kind of a provocative paper in the New England Journal of Medicine a year ago in April of last year from a Chinese group that looked at a CD7-based CAR T and it was 10 patients, but they used CD7 positive acute leukemia, AML or ALL and had a CD7-targeted CAR T and they actually incorporated that with a haploidentical transplant and they had really high remission rates. People tolerated it quite well. It was provocative. It hasn't yet been reproduced on a larger scale, but the strong hints that the strategy is going to work.  Now, CD33 is a little tricky to have a CAR T when CD33 is expressed on normal hematopoietic cells. CD123 likewise. That's been something where there's, I think, still promise, but we've struggled to find the trials that make that work. Right now, there's a lot of interest in leveraging NK cells and looking, for a couple of reasons, but NK cells are attractive and NK cell markers might be attractive targets. NK cells might have similar degrees of immune efficacy. It's speculative, but they are likely to have less cytokine release syndrome and less neurotoxicity than you see with CAR T. And so it's kind of attractive to leverage that. We have had some ongoing trials looking at it with bispecifics and there certainly are trials looking at it with CAR NK-based strategies. One of the antigens that people looked at is the NK group 2D. NK group 2D or NKG2D is overexpressed in AML and its ligands overexpressed. And so that's a particular potential target. So, John, it's happening and we're looking for the hints of efficacy that could then drive a pivotal trial to get something approved.  One of the other areas is not restricting yourself just to a single antigen. For instance, there is a compound that's looking at a multi-tumor-associated antigen-specific T-cell therapy, looking at multiple antigens in AML that could be overexpressed. And there were some hints of activity and efficacy and actually a new trial looking at a so-called multi-tumor associated antigen-specific T cell therapy. So without getting into specific conflicts of interest or trials, I do think that's an exciting area and an evolving area, but still an investigational area. I'll stop there and say that we're excited about it. A lot of work's going there, but I'm not quite sure which direction the field's going to pivot to there. I think that's going to take us some time to sort out. Dr. John Sweetenham: Yeah, absolutely. But as you say, exciting area and I guess continue to watch this space for now.  So you've mentioned allogeneic stem cell transplants two or three times during this discussion. Recognizing that we don't have an imatinib for AML, which has kind of pushed transplant a long way further back in the treatment algorithm, can you comment a little on, you know, whether you think the role of stem cell transplantation is changing in AML or whether it remains pretty much as it was maybe 10 years ago? Dr. James Foran: By the way, I love that you use imatinib as an introduction because that was 6 TKIs ago, and it tells you the evolution in CML and you know, now we're looking at myristoyl pocket as a target, and so on. That's a great way to sort of show you the evolution of the field.  Allogeneic transplant, it remains a core treatment for AML, and I think we're getting much smarter and much better about learning how to use it. And I'm just going to introduce the topic of measurable residual disease to tell you about that. So I am a little bit of a believer. Part of my job is I support our allogeneic transplant program, although my focus is acute myeloid leukemia, and I've trained in transplant and done it for years and did a transplant fellowship and all that. I'm much more interested in finding people who don't need a transplant than people who do. So I'm sort of looking for where can we move away from it. But it still has a core role. I'll sidestep and tell you there was an MDS trial that looked at intermediate or high-risk MDS and the role of allogeneic transplant that shows that you about double your survival. It was a BMT CTN trial published several years ago that showed you about double your three-year survival if you can find a donor within three months and get to a transplant within six months. And so it just tells you the value of allotransplant and myeloid malignancy in general. In AML we continue to use it for adverse risk disease – TP53 is its own category, I can talk about that separately – but adverse risk AML otherwise, or for patients who don't achieve a really good remission. And I still teach our fellows that an allotransplant decreases your risk of relapse by about 50%. That's still true, but you have to have a group of patients who are at high enough risk of relapse to merit the non-relapse mortality and the chronic graft versus host disease that comes with it. Now, our outcomes with transplant are better because we're better at preventing graft versus host disease with the newer strategies such as post-transplant cyclophosphamide. There are now new FDA-approved drugs for acute and chronic graft versus host disease, ruxolitinib, belumosudil, axatilimab now. So we have better ways of treating it, but we still want to be discriminating about who should get it.  And it's not just a single-minded one-size-fits-all. We learned from the MORPHO study that was published in the JCO last year that if you have FLIT3-positive AML, FLIT3/IDT-positive AML, where we would have said from retrospective studies that your post-transplant survival is 60% give or take, as opposed to 15% or 20% without it, that we can discriminate who should or shouldn't get a transplant. Now that trial was a little bit nuanced because it did not meet its primary endpoint, but it had an embedded randomization based upon MRD status and they used a very sensitive test of measurable residual disease. They used a commercial assay by Invivoscribe that could look at the presence of a FLT3/ITD in the level of 10 to the minus 5th or 10 to the minus 6th. And if you were MRD-negative and you went through a transplant, you didn't seem to get an advantage versus not. That was of maintenance with gilteritinib, I'll just sort of put that on there. But it's telling us more about who should get a transplant and who shouldn't and who should get maintenance after transplant and who shouldn't.  A really compelling study a year ago from I don't know what to call the British group now, we used to call them the MRC and then the NCRI. I'm not quite sure what to call their studies at the moment. But Dr. Jad Othman did a retrospective study a year ago that looked at patients who had NPM1 mutation, the most common mutation AML, and looked to see if you were MRD positive or MRD negative, what the impact of a transplant was. And if you're MRD negative there was not an advantage of a transplant, whereas if you're MRD positive there was. And when they stratified that by having a FLT3 mutation that cracked. If you had a FLT3 mutation at diagnosis but your NPM1 was negative in remission, it was hard to show an advantage of a transplant. So I think we're getting much more discriminating about who should or should not get a transplant by MRD testing for NPM1 and that includes the patients who have a concomitant FLT3 mutation. And we're really trying to learn more and more. Do we really need to be doing transplants in those who are MRD-negative? If you have adverse risk genetics and you're MRD-negative, I'll really need good data to tell me not to do a transplant, but I suspect bit by bit, we'll get that data. And we're looking to see if that's really the case there, too. So measurable residual disease testing is helping us discriminate, but there is still a core role of allogeneic transplant. And to reassure you, compared to, I think your allotransplant days were some time ago if I'm right. Dr. John Sweetenham: Yes. Dr. James Foran: Yeah. Well, compared to when you were doing transplants, they're better now and better for patients now. And we get people through graft versus host disease better, and we prevent it better. Dr. John Sweetenham: That's a great answer, James. Thanks for that. It really does help to put it in context, and I think it also leads us on very nicely into what's going to be my final question for you today and perhaps the trickiest, in a way. I think that everything you've told us today really emphasizes the fact that the complexity of AML treatment has increased, primarily because of an improved understanding of the molecular landscape of the disease. And it's a complicated area now. So do you have any thoughts on what type of clinical environment patients with AML should be evaluated and treated in in 2025? Dr. James Foran: Yeah, I want to give you a kind of a cautious answer to that because, you know, I'm a leukemia doctor. I work at a leukemia center and it's what we focus on. And we really pride ourselves on our outcomes and our diagnostics and our clinical trials and so on. I am very aware that the very best oncologists in America work in private practice and work in community practice or in networks, not necessarily at an academic site. And I also know they have a much harder job than I have. They have to know lung cancer, which is molecularly as complicated now as leukemia, and they have to know about breast cancer and things that I don't even know how to spell anymore. So it's not a question of competence or knowledge. It's a question of infrastructure. I'll also put a little caveat saying that I have been taught by Rich Stone at Dana-Farber, where I did a fellowship a long time ago, and believe Rich is right, that I see different patients than the community oncologists see with AML, they're seeing different people. But with that caveat, I think the first thing is you really want to make sure you've got access to excellence, specialized hematopathology, that you can get expedited cytogenetics and NGS testing results back. There was a new drug, approved just a few months ago, actually, for relapsed AML with a KMT2A rearrangement, revumenib. We didn't talk about the menin inhibitors. I'll mention them in just a second. That's a huge area of expansion and growth for us. But they're not found on NGS platforms. And normal cytogenetics might miss a KMT2A-rearrangement. And we're actually going back to FISH panels, believe it or not, on AML, to try to identify who has a KMT2A-rearrangement. And so you really want to make sure you can access the diagnostic platforms for that.  I think the National Referral Labs do an excellent job. Not always a really fast job, but an excellent job. At my institution, I get NGS results back within three days or four days. We just have an expedited platform. Not everybody has that. So that's the key, is you have to be able to make the diagnosis, trust the pathologist, get expedited results. And then it's the question of trying to access the targeted medications because a lot of them are not carried in hospital on formulary or take time to go through an insurance approval process. So that's its own little headache, getting venetoclax, getting gilteritinib, getting an IDH1 inhibitor in first line, if that's what you're going for. And so I think that requires some infrastructure. We have case managers and nurses who really expedite that and help us with it, but that's a lot of work. The other piece of the puzzle is that we're still with AML in the first month and maybe even the second month. We make everybody worse before we make them better. And you have to have really good blood bank support. I can give an outpatient platelet transfusion or red cell transfusion seven days a week. We're just built for that. That's harder to do if you're in a community hospital and you have to be collaborating with a local blood bank. And that's not always dead easy for somebody in practice. So with those caveats, I do find that my colleagues in community practice do a really good job making the diagnosis, starting people on therapy, asking for help. I think the real thing is to be able to have a regional leukemia center that you can collaborate with, connect with, text, call to make sure that you're finding the right patients who need the next level of diagnostics, clinical trial, transplant consults, to really get the best results.  There was some data at ASH a couple of years ago that looked at – the American Society of Hematology and ASCOs had similar reports – that looked at how do we do in academic centers versus community practice for keeping people on therapy. And on average, people were more likely to get six cycles of therapy instead of three cycles of therapy with azacitidine venetoclax at an academic center. Now, maybe it's different patients and maybe they had different cytogenetics and so on, but I think you have to be patient, I think you have to collaborate. But you can treat those patients in the community as long as you've got the infrastructure in place. And we've learned with virtual medicine, with Zoom and other platforms that we can deliver virtual care more effectively with the pandemic and beyond. So I think we're trying to offer virtual consults or virtual support for patients so they can stay in their home, stay in their community, stay with their oncologists, but still get access to excellent diagnostics and supportive care and transplant consults, and so on. I hope that's a reasonable answer to that question. It's a bit of a nuanced answer, which is, I think there's an important role of a leukemia center, and I think there's a really fundamental role of keeping somebody in the community they live in, and how we collaborate is the key to that. And we've spent a lot of time and effort working with the oncologists in our community to try to accomplish that.  John, I want to say two other things. I didn't mention in the molecular platforms that NPM1 mutations, we can now target those on clinical trials with menin inhibitors. We know that NPM1 signals through the Hoxa9/Meis1 pathway. We know that similar pathways are important in KMT2A rearrangements. We know that there are some other rare leukemias like those with NUP98 rearrangement. We can target those with menin inhibitors. The first menin inhibitor, revuminib, was approved by the FDA for KMT2A. We have others going to the FDA later this year for NPM1. There are now pivotal trials and advanced expanded phase 1/2 studies that are showing 30% response rates. And we're looking to see can we add those into the first-line therapy. So, we're finding more targets.  I'll say one last thing about molecular medicine. I know I'm a little off topic here, but I always told patients that getting AML was kind of like being struck by lightning. It's not something you did. Now, obviously, there are risk factors for AML, smoking or obesity or certain farm environments, or radioactive exposures and so on. But bit by bit, we're starting to learn about who's predisposed to AML genetically. We've identified really just in the last five or eight years that DDX41 mutations can be germline half the time. And you always think germline mutations are going to cause AML in a younger patient, but the median age is 60 to 70 just like other AMLs. They actually might do pretty well once they get AML. We've reported that in several papers. And so we're trying to understand who that has a RUNX1 mutation needs germline testing, who with a DDX41 needs germline testing. And we're trying to actually come up with a cleaner pathway for germline testing in patients to really understand predisposition, to help with donor selection, to help with family counseling. So I think those are other areas where a leukemia center can contribute for somebody in who's community practice to understand genomic or genetic complexity in these patients. And we're starting to develop the databases that support that. Dr. John Sweetenham: Yeah, great. Thanks, James. I loved your answer about the clinical environment too. And I know from a patient-centric perspective that I know that patients would certainly appreciate the fact that we're in a situation now where the folks taking care of them will make every effort to keep them close to home if they possibly can.  I want to thank you, James, for an incredible review of a very complex subject and I think you did a great job. I think we all will have learned a lot. And thanks again for being willing to share your insights with us today on the ASCO Daily News Podcast. Dr. James Foran: John, it's my pleasure. And as you know, I'll do anything for a latte, so no problem at all. Dr. John Sweetenham: Okay. I owe you one, so thank you for that.  And thank you to our listeners for your time today. You'll find links to the studies we've discussed today in the transcript of this episode. And finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:  Dr. John Sweetenham  Dr. James Foran Follow ASCO on social media: @ASCO on Twitter ASCO on Bluesky ASCO on Facebook  ASCO on LinkedIn  Disclosures:    Dr. John Sweetenham:    No relationships to disclose Dr. James Foran: Stock and Other Ownership Interests: Aurinia Pharmaceuticals Consulting or Advisory Role: Peerview, CTI BioPharma Corp, Remix Therapeutics, Cardinal Health, Medscape, Syndax, Autolus Therapeutics Research Funding (Inst.): Chordia Therapeutics, Abbvie, Actinium Pharmaceuticals, Kura Oncology, Sellas Life Sciences, Novartis, Roivant, Celgene/Bristol-Myers Squibb, Astellas Pharma, SERVIER Travel, Accommodations, Expenses: Peerview

Learn Smarter
350: Our Favorite Academic Accommodations Part 2 (Educational Therapy Series)

Learn Smarter

Play Episode Listen Later Mar 4, 2025 15:47


Rachel Kapp, M.Ed., BCET, and Stephanie Pitts, M.Ed., BCET complete their 4-part series about accommodations. In episode 347, they chatted about what accommodations are, why they're important, and common misconceptions about them. Then in episode 348, they discussed why some accommodations don't work as intended (despite the best of intentions). In last week's episode, episode 349, they discussed some of their favorite accommodations. Listen today to hear the last 5 accommodations that they love and why. Support us on Patreon: https://www.patreon.com/learnsmarterpodcast   How to connect with us: Join our e-mail list Rachel's Kapp Educational Therapy Group website Steph's My Ed Therapist website  @learnsmarterpodcast, @kappedtherapy, @myedtherapist   Other episodes mentioned: Ep 347: All You Need to Know About Accommodations (Educational Therapy Series) Ep 348: Why Some Accommodations Don't Help (Educational Therapy Series) Ep 349: Our Favorite Academic Accommodations Part 1 (Educational Therapy Series)

Work For Humans
Beyond Accommodations: How Personalization at Work Benefits Everyone | Charlotte Dales

Work For Humans

Play Episode Listen Later Mar 4, 2025 53:49


Most employees need some form of support to thrive at work, whether it's flexible hours to care for a loved one, mental health resources, or a quieter space to focus. But asking for help can feel risky. That silence holds people back and costs companies more than they realize. Charlotte Dales is trying to fix that. As the co-founder and CEO of Inclusively, Charlotte is building a platform that helps employees easily and privately access the support they need to do their best work. From mental health tools for sales teams to caregiving support for frontline workers, Inclusively is proving that when employees thrive, businesses thrive too.In this episode, Dart and Charlotte discuss:- Why everyone needs accommodations at work- The hidden costs of silence and burnout- What sales teams need to thrive- Small adjustments that unlock performance- Why benefits fall short and what people really need- Gen Z's push for personalized work- ERGs as engines of workplace change- Why supporting employees is smart business- And other topics...Charlotte Dales is the co-founder and CEO of Inclusively, a platform helping companies design personalized, inclusive work experiences. Starting with a focus on disability accommodations, Inclusively has expanded to offer “success enablers” for all employees, allowing businesses to match individual needs with existing resources. Before founding Inclusively, Charlotte co-founded CAKE Technologies, a mobile payment solution later acquired by American Express. She started her career in investment banking at Deutsche Bank in London.Resources Mentioned:Inclusively: https://www.inclusively.com/Connect with Charlotte:LinkedIn: https://www.linkedin.com/in/charlotte-dales-57868713/Work with Dart:Dart is the CEO and co-founder of the work design firm 11fold. Build work that makes employees feel alive, connected to their work, and focused on what's most important to the business. Book a call at 11fold.com.

Parenting Anxious Teens | Parenting Teens, Managing Teen Anxiety, Parenting Strategies
36 | A Psychologist's Guide to CBT, School Refusal and Reducing Anxiety Accommodations with Dr. Regine Galanti

Parenting Anxious Teens | Parenting Teens, Managing Teen Anxiety, Parenting Strategies

Play Episode Listen Later Mar 4, 2025 49:50


Hi Parents! If your teen struggles with anxiety, school refusal, or avoidance, you're not alone. Many parents unknowingly reinforce anxious behaviours by offering constant reassurance or making accommodations to reduce distress - but what if these well-intentioned actions are actually keeping your teen stuck? In today's episode, I sit down with Dr. Regine Galanti, a clinical psychologist who works with children, teens, and families navigating anxiety. We discuss why avoidance strengthens anxiety, how CBT strategies empower teens to face fears, and the role of parents in reducing accommodations while still providing support. Dr. Galanti offers practical steps to help your teen build resilience and confidence - without feeling overwhelmed. More About Dr. Galanti: She is a leading expert in anxiety, OCD, and behaviour challenges. She is the founder of Long Island Behavioral Psychology and has been featured in The New York Times and The Washington Post for her work in child and adolescent mental health. She is the author of:

Shanahan on Literacy
Accommodating Reading Comprehension with Listening: Good Idea?

Shanahan on Literacy

Play Episode Listen Later Mar 1, 2025 9:17


Many children suffer from difficulties learning to read and sometimes these challenges take the form of disabilities. The question is should accommodations be provided to these students by replacing listening comprehension with reading comprehension, if we know they will have trouble decoding. This podcast considers the value of such accommodations when it comes to reading.

Healing with WORTH
Beyond Diagnosis: Boundaries are Necessary for Healthy Recovery

Healing with WORTH

Play Episode Listen Later Feb 27, 2025 28:08


Creating Safety and Boundaries in Relationships Amid Mental Health ChallengesIn this episode of Healing with Worth, hosts Naomi and Marquelle discuss the challenges of dealing with spouses who have mental health issues and addictions. They emphasize the importance of setting boundaries and maintaining safety in relationships, regardless of a spouse's diagnosis. The hosts provide insights into why relying solely on a diagnosis for comfort might not be effective and stress the significance of self-care and personal healing. The episode also includes practical advice on role adjustments and boundary-setting to ensure respect and safety in the relationship.00:00 Introduction to Healing with Word00:06 Understanding Mental Health and Addiction03:27 The Importance of Boundaries04:34 Accommodations and Limitations08:32 Focusing on Self-Healing14:22 Creating Safety Through Boundaries24:21 Starting Your Recovery Journey

Beyond the Wild
Episode 37

Beyond the Wild

Play Episode Listen Later Feb 27, 2025 82:45


In this episode of Beyond the Wild, hosts Ron, Jason, and Mark welcome Cam Scott, a nature photographer and guide from South Africa. The crew explore Cam's journey into nature photography, the life changes he made to pursue his passion, and the profound impact of nature on personal growth. Cam shares his experiences with a wide range of animals, including mountain gorillas, jaguars, leopards, lions, elephants and shoe-billed storks. Cam shares his views on the art of guiding and the challenges he faced in launching his own business during the pandemic. The discussion emphasizes the importance of a positive attitude and the joy of wildlife encounters. Cam and the crew delve into the intricate relationships between humans and wildlife, particularly focusing on gorillas and the impact of tourism on conservation efforts. They share personal anecdotes of memorable wildlife encounters, discuss the importance of understanding animal behavior, and highlight the unique experiences offered by locations like Mana Pools National Park in northern Zimbabwe. Sound Bites"I was up at 3 a.m. I thought I would look like a car wreck.""I never looked back.""You have to go through it.""I want to photograph early morning lights.""You can see it the moment you lock eyes.""It's a phenomenal experience.""I just want to go back to Rwanda.""Tourism has saved these gorillas.""It's not just seeing a gorilla.""The lighting is absolutely phenomenal.""Anything's possible in Africa.""It's a beautiful day to be alive."Chapters03:04 Cam's Journey into Nature Photography06:12 Life Changes and Career Shifts08:48 The Impact of Nature on Personal Growth12:11 Experiences with Mountain Gorillas15:00 The Art of Guiding and Manifesting Experiences18:02 Challenges and Triumphs in Business20:48 The Power of Positive Attitude24:05 Wildlife Encounters and Photography26:59 The Fascinating Shoe-Billed Stork38:00 Confrontation and Respect in the Animal Kingdom39:01 Understanding Gorilla Behavior and Communication39:49 The Connection Between Humans and Nature41:13 The Importance of Gorilla Tourism for Conservation42:06 The Role of Tourism in Supporting Local Communities42:48 Experiencing Wildlife: The Thrill of Close Encounters46:09 The Sounds of Nature: A Sensory Experience51:00 Memorable Outdoor Encounters57:51 Exploring Monopools: A Photographer's Paradise01:05:02 Accommodations and Immersive Experiences in Africa01:12:55 Planning Your African AdventureLINKSCam Scott@CamScott_WildThe Best Of Authentic ZimbabweTour Opportunity: September 22-30th 2025https://itineraries.safariportal.app/The-Best-of-Authentic-Zimbabwe/1338943500867078002Thanks for listening to the Beyond the Wild Podcast. Remember to subscribe to be notified of upcoming episodes for your listening and viewing enjoyment! Beyond the Wild Podcast is sponsored by Pictureline.com and Canon USA.

Learn Smarter
349: Our Favorite Academic Accommodations Part 1 (Educational Therapy Series)

Learn Smarter

Play Episode Listen Later Feb 25, 2025 17:03


Rachel Kapp, M.Ed., BCET, and Stephanie Pitts, M.Ed., BCET continue their 4-part series about accommodations. In episode 347, they chatted about what accommodations are, why they're important, and common misconceptions about them. Last week, in episode 348, they discussed why some accommodations don't work as intended (despite the best of intentions). In today and next week's episodes, Rachel and Steph dig into their top 10 favorite accommodations and discuss why they like them and how they are useful. Support us on Patreon: https://www.patreon.com/learnsmarterpodcast   How to connect with us: Join our e-mail list Rachel's Kapp Educational Therapy Group website Steph's My Ed Therapist website  @learnsmarterpodcast, @kappedtherapy, @myedtherapist   Other episodes mentioned: Ep 347: All You Need to Know About Accommodations (Educational Therapy Series) Ep 348: Why Some Accommodations Don't Help (Educational Therapy Series)

Texas Standard
Major airlines target rule setting standard for disability accommodations

Texas Standard

Play Episode Listen Later Feb 24, 2025 51:19


What would be the implications for a Texas constitutional amendment “protecting the right of parents to raise their children”? Blaise Gainey of The Texas newsroom tells us who’s pushing it and the questions surrounding it.Texas-based Southwest and American Airlines are joining with Delta, JetBlue and United to ask a court to overturn a rule requiring […] The post Major airlines target rule setting standard for disability accommodations appeared first on KUT & KUTX Studios -- Podcasts.

Fight Like a Mother
102: What kind of world do you want to live in?

Fight Like a Mother

Play Episode Listen Later Feb 19, 2025 64:05


My guest on this episode is disability educator and advocate Amy Webb.   Due to the current events happening at this particular time.  Amy and I discuss the ramificaitons of the Texas vs Becerra lawsuit concerning section 504 of federal law.  Seventeen states are suing, stating that section 504 is unconstitutional.  Section 504 of the law protects disabled individuals from discrimintation.  It was passed in 1973 due to incredible disable activists who fought for their rights over 50 years ago and now it is on the brink of being stripped away. Amy shares some amazing history and thoughts about the disabled community and the dignity and worth they bring to all of us in society.  Some of the really important points she brings to the pod are: *When you design for people on the margins you don't leave anyone out. *Accommodations for the disabled give to everyone. *These accomodations don't leave anyone out, and in fact bring inclusion to all. *What kind of world do we want to live in?  The one of giving our most vulnerable civil rights? Or stripping away 50+ years of hard fought for civil rights. *The disable deserve to be met with dignity and accommodations to get health care, school support etc.   *We must listen to disabled voices and the advocates and activists in the community. Amy gives two tips to anyone who needs to advocate for the disabled (especially parents): Speak up when you can and how it works for you. Educate yourself on the disabled community, on laws, on diagnoses that can receive services etc. Although we talked about a time sensitive issues of the 504 lawsuit, the history talked about and the principles of inclusion and advocacy apply to any situation. Amy's website: thislittlemiggy.com Amy's books: https://a.co/d/9n5jXQx https://a.co/d/bvRHUm8 https://a.co/d/hF1iXpn Crip Camp https://www.netflix.com/title/81001496

Parenting ADHD Podcast, with the ADHD Momma | Positive Parenting | ADHD Tools | Homework Strategies | ADHD at School | Learni
300: 5 Myths That Hurt Neurodivergent Kids (And What to Do Instead!), with Penny Williams

Parenting ADHD Podcast, with the ADHD Momma | Positive Parenting | ADHD Tools | Homework Strategies | ADHD at School | Learni

Play Episode Listen Later Feb 13, 2025 23:25


In this milestone 300th episode of Beautifully Complex, I'm going deep into the misconceptions that many of us face raising neurodivergent kids and that unjustly limit our children's potential.Join me as I bust the top 5 myths that hurt neurodivergent kids and then provide strategies to challenge outdated thinking and empower your journey as a parent. We'll tackle the misconception that neurodivergent kids just need to try harder, reveal why success doesn't hinge on fitting in, and highlight the myriad paths to achieving a fulfilled life beyond traditional ideas. Learn why discipline isn't the answer and discover how advocating for accommodations can level the playing field, not create unfair advantages.In this episode, you'll find practical, step-by-step advice to build a neuro-affirming environment, encouraging your child to be authentically themselves. By recognizing and celebrating strengths, we can foster a sense of self-trust and inspire hope for a bright future.Whether you're looking for validation, guidance, or actionable tips, this episode is your go-to resource for fostering success and understanding for neurodivergent children. Let's equip ourselves with the tools to support our kids right where they are and navigate the beautifully complex world of neurodivergence together.Tune in and transform your parenting mindset with expertise honed from personal experience and the trenches of neurodivergent parenting.You can find additional resources at parentingadhdandautism.com and Regulated Kids.com — because it's not just about the struggles, it's about progress, one step at a time.Show notes and more resources at parentingadhdandautism.com/300Become a supporter of this podcast: https://www.spreaker.com/podcast/beautifully-complex--6137613/support.

The Dana & Parks Podcast
Accommodations: Are you responsible to make sure you get what you need? Hour 1 2/11/2025

The Dana & Parks Podcast

Play Episode Listen Later Feb 11, 2025 36:15


Accommodations: Are you responsible to make sure you get what you need? Hour 1 2/11/2025 full 2175 Tue, 11 Feb 2025 20:00:00 +0000 KRMXckgupsR63XavgJ7CNPW6VOXAz2f8 news The Dana & Parks Podcast news Accommodations: Are you responsible to make sure you get what you need? Hour 1 2/11/2025 You wanted it... Now here it is! Listen to each hour of the Dana & Parks Show whenever and wherever you want! 2024 © 2021 Audacy, Inc. News False http