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8 episodes with dhm
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2 episodes with dhm
2 episodes with dhm
2 episodes with dhm
2 episodes with dhm
2 episodes with dhm
2 episodes with dhm
As startups grow, product teams often find themselves caught between speed and structure. In this episode of The Product Experience, Charlotte King, Lead Product Manager at eBay, shares practical insights from her work leading teams through this transition at companies including Moonpig, Flipdish, and ThoughtWorks. Charlotte unpacks how to define product's role during scaleup, build team structure around strategic value, and use tools like Wardley Mapping and Team Topologies to support organisational change. She also introduces the DHM model (Delightful, Hard to copy, Margin-enhancing) and discusses how to make strategy tangible for cross-functional teams. This conversation is especially useful for product leaders, heads of product, and founders navigating scale.Chapters1:13 – Charlotte's background2:36 – Product's role in startups, scaleups and enterprises4:35 – What product teams need to succeed during scale6:42 – Defining product's role as the company grows9:00 – Using Wardley Mapping to assess team maturity14:30 – Creating and communicating guiding principles20:30 – Using the DHM model to prioritise value25:48 – Structuring teams with Team Topologies29:03 – Multidisciplinary collaboration in practice30:41 – Lessons from leading transformation32:30 – Final reflections and takeawaysFeatured Links: Follow Charlotte on LinkedIn | eBay | Wardley Maps | What we learned at #mtpcon London 2025' feature by Kent McDonald and Louron PrattOur HostsLily Smith enjoys working as a consultant product manager with early-stage and growing startups and as a mentor to other product managers. She's currently Chief Product Officer at BBC Maestro, and has spent 13 years in the tech industry working with startups in the SaaS and mobile space. She's worked on a diverse range of products – leading the product teams through discovery, prototyping, testing and delivery. Lily also founded ProductTank Bristol and runs ProductCamp in Bristol and Bath. Randy Silver is a Leadership & Product Coach and Consultant. He gets teams unstuck, helping you to supercharge your results. Randy's held interim CPO and Leadership roles at scale-ups and SMEs, advised start-ups, and been Head of Product at HSBC and Sainsbury's. He participated in Silicon Valley Product Group's Coaching the Coaches forum, and speaks frequently at conferences and events. You can join one of communities he runs for CPOs (CPO Circles), Product Managers (Product In the {A}ether) and Product Coaches. He's the author of What Do We Do Now? A Product Manager's Guide to Strategy in the Time of COVID-19. A recovering music journalist and editor, Randy also launched Amazon's music stores in the US & UK.
In this episode of Thrive Radio, I sits down with Daniel Addix, co-founder of LCU, a company pioneering hangover recovery with the world's first DHM-based gummies. Daniel shares his personal journey from battling the dreaded hangover to developing a science-backed, patent-pending solution that helps people feel refreshed after a night out. From overcoming product development hurdles to expanding into retail and bars, Daniel's story is one of resilience, innovation, and passion for wellness. Tune in for insights into the challenges of launching a new wellness product and the growing alcohol aid market. What you will learn in this podcast: How Daniel Addicks turned his personal struggle with hangovers into a business idea that led to the creation of a patented DHM-based gummy. The role of DHM, a compound from the Japanese raisin tree, in alleviating hangover symptoms and boosting liver health. The process and challenges of product development, including the trials and lessons learned when their first manufacturer didn't deliver. Insights into the booming alcohol aid market and how LCU's strategy includes targeting bars, retail stores, and even expanding into event activations. Essential advice for aspiring entrepreneurs entering the wellness and supplement space, particularly regarding ingredient sourcing, product testing, and manufacturing costs.
James B. LaValle, B.S.Pharm, CCN, MT, DHM, DHPh is an internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 40 years of clinical experience in natural products, lifestyle, drug/nutrient depletion, compounding pharmacy and peptides. He has served thousands of clients, using a metabolic model for health, at his facilities in Orange County, CA, Austin, TX and formerly at LaValle Metabolic Institute, in Cincinnati Ohio. He is the founder of Metabolic Code Enterprises, (www.metaboliccode.com) that pinpoints the metabolic roadblocks to health using a symptom survey, lab markers, biometrics, and wearable data. He taught for 18 years as an appointed adjunct faculty member at the University of Cincinnati College of Pharmacy served as faculty at the College of Medicine at U.C. He is Adjunct Faculty for the Masters of Integrative Medicine program at the George Washington School of Medicine and Health Sciences. Dr. Swidan is President and CEO of NeuroPharm and Former CEO of Pharmacy Solutions in Ann Arbor, MI and Adjunct Associate Professor of Clinical Research and Leadership at George Washington University School of Medicine and Health Sciences, and Adjunct Clinical Associate Professor of Pharmacy at Wayne State University. She received her Doctor of Pharmacy degree and completed a 3-year research Fellowship in Bio-Pharmaceutics and Gastroenterology at the University of Michigan. Following her fellowship, she was Director of Pharmacy at Chelsea Community Hospital and the clinical pharmacist for the inpatient head and chronic pain service. Dr. Swidan is board certified and an advanced fellow in anti-aging and regenerative medicine. She is an internationally renowned speaker in the areas of pain management, headaches, and HRT. She has authored several book chapters, articles, and patient education material in head and general pain management and personalized medicine.
Nile Rogers of Chic Live on Game Changers With Vicki Abelson This sit-down with my old friend, multiple Grammy Winner, Rock & Roll Hall Inductee, Songwriters Hall of Fame Inductee, composer, producer, arranger, and guitarist, Nile Rogers, is SOLID GOLD… more like triple platinum. Even though we never exchanged more than a few words in the handful of times he graced my jams back in the day, there was always DHM (deep hidden meaning), as there always is with Nile. This day, we got to that and so much more. STORIES! Oh my lord, No one tells ‘em like Nile. Case in point, his tome, Le Freak, may be the greatest memoir I've read. I could not put the thing down. When was the last time I read a book cover to cover in less than 24 hours? A rare score on Amazon these days, Nile's assured he'll be updating and republishing. It's a MUST-read for music fans, flower children, and anyone who loves to sink their teeth into a great story, well-told. Nile covered his very humble early days, his barely older than him mother, the drugs, the bi-coastal extended family, the moves, the schools, early influences from Coltrane to The Beatles, flute to clarinet to guitar… how Bernard Edwards got him to the Hitmaker Strat and chucking, which has become synonymous with Nile's style. We talked the DHM, the breakdown, the Chic magic as well as the music during and since… producing the top of the top for Sister Sledge, Diana Ross, Madonna, David Bowie, Duran Duran, still winning Grammys and kicking it with Daft Punk, Beyonce, and Cold Play, to name but a few, 750 MILLION albums worth. Say what? We got the sweetest stories about Michael Jackson… a funny with Keith Richards, a Grace Jones impression, and a scary story about Nile's coke psychosis leading to him bottoming out and getting clean and sober. 31 years worth and counting… That Nile was able to do all that he's done, and it's Herculean - aside from the massive number of hits, the films he's scored, the shows he's played, there's the We Are Family Foundation, Chairing the Songwriters Hall of Fame, receiving the 2024 World Economic Forum's Crystal Award for his extraordinary efforts to make the world a more peaceful, equal, and inclusive place… Nile is a humanist, a gentle soul with a heart of platinum like the records that line his walls. I've always admired, respected, and adored Nile. After reading Le Freak, and spending this time with him, I cherish him all the more. What a man, what a man, what a mighty fine man! Nile Rogers of Chic Live on Game Changers With Vicki Abelson Wednesday, 4/2/25, 11AM PT, 2 PM ET Streamed Live on my Facebook and on my YouTube FB Replay here: https://bit.ly/4cmPP2u YouTube replay here: https://www.youtube.com/watch?v=q875x2lVyLE
Does Morning Recovery or dihydromyricetin (DHM) help hangovers? Dive into our critical analysis of Morning Recovery as we uncork the research and separate the sober truth from fiction. For more information about this topic: https://brianyeungnd.com/2024/09/05/doctor-reviews-morning-recovery/ Get EXCLUSIVE content and SUPPORT us: https://ko-fi.com/brianyeungnd Top recommended alternatives to Morning Recovery: DHM - https://amzn.to/49JNQCO - 1 cap as needed Panax ginseng - https://amzn.to/451CXKl - 1 cap as needed
Metabolic Mastery with James B. LaValle R.Ph., C.C.N. M.T. DHM, DHPh James LaValle is an internationally recognized clinical pharmacist, author, board-certified clinical nutritionist, and expert and educator in integrative and precision health. James is best known for his expertise in personalized integrative therapies uncovering the underlying metabolic issues that keep people from feeling healthy and vital. A thought leader in drug/nutrient depletion issues he has published 4 books and 3 databases in this area alone. As such he has over 35 years' experience integrating natural and integrative therapies into various medical and business models. His latest research is in drug-induced microbiome disruption. Through his practices, including LaValle Metabolix in Orange County, CA, LaValle has served thousands of patients, from individuals managing chronic health issues to elite athletes in professional sports organizations like the NFL, NHL, and MLB. In 2019, he was named Integrative Medicine Program Director for the NFL Hall of Fame Health and Performance Program. He also works with military Special Forces to enhance resilience and metabolic performance. Other Industry Highlights include a venture in 2010 with Life Time Fitness, the largest publicly traded fitness company in the US (NASDAQ: LTM), providing nutrition and metabolism expertise and developing Life Time's national nutrition education, protocol design and product development initiatives related to weight loss and prevention. This entailed educating close to 2700 fitness trainers, 20 dieticians and reaching some 1.2 million Life Time fitness members. LaValle is an accomplished educator, serving as a clinical instructor at George Washington University and earning awards for his contributions to integrative medicine. He has appeared in over 1,000 media interviews, contributed to influential scientific databases, and partnered with major companies like Bayer and CVS on health initiatives. His work continues to impact healthcare by advancing personalized, integrative approaches to well-being and metabolic health optimization. Website Link: James LaValle interview, Life Time Fitness, Metabolic Mastery, metabolic health optimization, cutting-edge microbiome research, transformative nutrition strategies, advanced metabolic therapies, holistic health innovation, drug-nutrient synergy, precision wellness insights
Part two of our episode with DHM pollster John Horvick. Bryan, Reagan, and John discuss the debate, the Supreme Court decision in the Grants Pass case, and education politics , cell phone bans in schools. Bryan gets frustrated with millennials who don't lave voicemails.* John Horvick Explains the Polls: Part One* Morning Consult Tracking Biden's Approval Rating in All 50 States* College degree by Oregon House of Representative district (2022)* HB 3115 (2021)* Audience numbers for past presidential debates* President George W. Bush “Now watch this drive” This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.crosstabs.studio
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Alcohol and longevity — it's an extremely controversial topic that most health experts shy away from. But I'm not afraid of courting controversy when there's scientific evidence to consider. Sure, you've heard the warnings about alcohol being a toxin that should be avoided at all costs — and in some cases this is true. But what if I told you that in moderate amounts (emphasis on moderate), alcohol can actually be beneficial for longevity and brain health? In this episode, I'm diving deep into the latest research on alcohol's effects on your body, and why I choose to drink almost every single day. First, I'll explain the concept of mitohormesis — how temporary stressors like alcohol can actually boost your mitochondrial function and resilience when consumed in the right amounts. Next, you'll gain insights into finding the "Goldilocks Zone" for your alcohol intake — the amount of alcohol consumption that provides health benefits without the notorious downsides of drinking too much booze. I'll also discuss supplements like dihydromyricetin (DHM) that can block alcohol's intoxicating effects while still allowing you to reap the rewards of moderate drinking. Additionally, you'll hear about using binders like chlorella, charcoal, and fruit pectin to remove toxins like acetaldehyde from your body after drinking, my routine for enjoying a nightly glass of organic wine or a cocktail, and recommendations for healthier alcoholic beverage choices like Dry Farm Wines, shrubs, and even ketone "alcohol" alternatives. Whether you're a teetotaler or a casual drinker, this episode might just reshape your thoughts around alcohol. By the end, if you choose to partake in this longevity strategy, you'll have a step-by-step game plan for your own conscientious alcohol consumption. For the full show notes, visit: https://bengreenfieldlife.com/alcohol Episode Sponsors: Kineon: Visit shop.kineon.io/bengreenfield today and receive 10% off your purchase. Timeline Nutrition: Go to timelinenutrition.com/BEN and use code BEN to get 10% off your order. Jigsaw Health: Visit JigsawAC.com and use "Greenfield10" to get 10% off on your order. Kreatures of Habit: Go to kreaturesofhabit.com/ben and use code BGL20 for 20% off your first purchase. Air Doctor: Visit airdoctorpro.com/beng now to save big.See omnystudio.com/listener for privacy information.
In episode #301 of The Hormone P.U.Z.Z.L.E Podcast, our host Dr. Kela Smith talks about Unlocking Fertility Secrets with the Hormone Puzzle Method – My Journey as a Fertility Doctor. More about Dr. Kela: Dr. Kela Smith, Ph.D., DNM, DHM, MNM, BCFN, BCHC is a leading Holistic Integrative Fertility & Hormone Doctor, dedicated to supporting women and couples facing fertility challenges. After overcoming her own fertility struggles using the Hormone P.U.Z.Z.L.E Method, it has been her mission to help others solve their infertility puzzles so they can get and stay pregnant, have a healthy happy pregnancy, and easy postpartum. An accomplished author, she also hosts The Hormone P.U.Z.Z.L.E Podcast, Solving-Infertility Summit, and Healthy Happy Pregnancy Summit. Dr. Kela's expertise also extends to guiding and inspiring future fertility experts as the lead educator at the Hormone Puzzle Society Educational Institute for Coaches. With vast experience and dedication to holistic health, she's a renowned authority in her field. Join her in solving the infertility puzzle at www.hormonepuzzlesociety.com Thank you for listening! This episode is made possible by Puzzle Brew's Fertility Tea: https://hormonepuzzlesociety.com/fertility-tea Follow Dr. Kela on Instagram: @kela_healthcoach https://www.instagram.com/kela_healthcoach Get your FREE Fertility Meal Plan: https://hormonepuzzlesociety.com/ FTC Affiliate Disclaimer: The disclosure that follows is intended to fully comply with the Federal Trade Commission's policy of the United States that requires to be transparent about any and all affiliate relations the Company may have on this show. You should assume that some of the product mentions and discount codes given are "affiliate links", a link with a special tracking code This means that if you use one of these codes and purchase the item, the Company may receive an affiliate commission. This is a legitimate way to monetize and pay for the operation of the Website, podcast, and operations and the Company gladly reveals its affiliate relationships to you. The price of the item is the same whether it is an affiliate link or not. Regardless, the Company only recommends products or services the Company believes will add value to its users. The Hormone Puzzle Society and Dr. Kela will receive up to 30% affiliate commission depending on the product that is sponsored on the show. For sponsorship opportunities, email HPS Media at media@hormonepuzzlesociety.com
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh, is an internationally recognized Heart and Immune Health Expert with over 37 years of clinical experience. He is a clinical pharmacist, author, board-Certified Clinical Nutritionist, and founder of Metabolic Code Enterprises, Inc. I highly recommend his book, Your Blood Never Lies: How to Read a Blood Test for a Longer, Healthier Life, and his groundbreaking bestseller, Cracking the Metabolic Code: 9 Keys to Optimal Health. Our topic this week was: Your HEART & IMMUNE Health Strategy this season! We also took a few listener questions. Mr Lavalle's appearance was arranged by our long time sponsor, Kyolic Aged Garlic. This links to their Omeg-AGE formula and this one to the Immune Product that Jim discussed. To review all products, CLICK HERE.
Dr. Kela Smith, Ph.D., DNM, DHM is a leading Holistic Integrative Fertility & Hormone Doctor, dedicated to supporting women and couples facing fertility challenges. After overcoming her own fertility struggles using the Hormone P.U.Z.Z.L.E method, it has been her mission to help others solve their infertility puzzles so they can get and stay pregnant, have a healthy happy pregnancy, and easy postpartum. An accomplished author, she also hosts The Hormone P.U.Z.Z.L.E Podcast, Solving-Infertility Summit, and Healthy Happy Pregnancy Summit. Dr. Kela's expertise also extends to guiding and inspiring future fertility experts as the lead educator at Fertility Coach University. With vast experience and dedication to holistic health, she's a renowned authority in her field. Join her in solving the infertility puzzle at www.coachkela.comConnect with Dr. Kela: Website | Instagram* The Baby Dust Fertility Podcast is hosted by Hannah Bowers. Follow her on Instagram for tips, insight, and encouragement.* New to TTC? Download our FREE eBook.* Want to improve your fertility? Enroll in Hannah's course, “The Fertility Roadmap,” where she walks you through identifying peak fertility, which pregnancy tests to use, proven lifestyle shifts for balanced hormones, and so much more. Sign up here.Support the ShowLove the show? Support the Baby Dust Fertility Podcast by shopping through our affiliate links when placing your next order.* Favorite Products (Amazon)* Fullwell Prenatal, Nourished Nerves & More save with code BLISSBERRYWELLNESS* Seeking Health Prenatal for Him & Her DM for latest coupon code.* needed. Powdered Prenatal, Pre/Probiotic, Egg Quality Support & More save with code BLISSBERRYWELLNESS20* Inito Fertility Monitor save with code HANNAH15* Proov Complete, PdG Tests, Balancing Oil & More save with code blissberrywellness* Tempdrop Wearable Fertility Monitor save with code blissberrywellnessDisclaimer: This email is for educational purposes only and does not constitute medical advice. Please speak to your care provider before making any changes to your diet, lifestyle, or currently prescribed medications. *This email contains affiliate links. You will not be charged extra for purchasing through one of our links, but a small portion of the proceeds will go to support Baby Dust. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit babydust.substack.com
Listen as Martin Johnson, DHM & founder of Total Health Nutriton Centers explains how to keep your immune system strong and which products to use during this season of unusual viral strains and symptoms. Call for a free 15 minute consultation to learn more about how we can help with your health: 262-251-2929. For more information or to view store locations visit: https://www.totalhealthinc.com.
Have you ever indulged in a drink (or a few) and found yourself waking up with a headache, a foggy feeling, or an upset stomach the next day? The enzymes in your liver play a crucial role in converting alcohol toxins into harmless substances.But as we age, our enzyme production tends to decrease, resulting in a higher concentration of toxins lingering in our system.Enter H-PROOF. The revolutionary “Anytime You Drink” Vitamin boosts the production of enzymes essential for alcohol metabolism, facilitating the transformation of alcohol and its associated toxins into benign substances. Additionally, it replenishes the vitamins and electrolytes expended during this process, offering a plethora of other beneficial elements that contribute to the well-being of your brain, liver, and overall bodily functions.Rachel Kaplan Grossman, CEO, and co-founder of H-PROOF, opens up about the inspiration behind the chewable vitamin and partnering with her mother on the science. She uncovers the secrets to turning alcohol and its toxins into harmless substances. Rachel reveals the science behind the aging process, the impact on enzyme production, and why H-PROOF is a game-changer, especially for those over 35. She joins podcast hosts Amber Berger and Dina Wizmer for an honest conversation about the science behind H-PROOF's formula, its effectiveness, and how it goes beyond just addressing the symptoms of a hangover. Amber opens up about her discovery of H-PROOF during the challenges of the COVID era, revealing how it transformed her occasional indulgence into a biohacking treat. Learn about the upcoming limited-edition flavor and get a sneak peek into H-PROOF's plans for future product releases. H-PROOF DISCOUNT CODE: “TheWellDrop” for 20% off first order Topics Discussed: -Anytime You Drink Vitamin: H-PROOF's debut product is the "Anytime You Drink Vitamin," a chewable vitamin designed to support alcohol metabolism, replenish vitamins and electrolytes, and promote overall brain, liver, and body health.-Alcohol Metabolism Process and Enzymes: As people mature, they tend to produce fewer enzymes responsible for metabolizing alcohol, leading to increased toxins in the system.-The Science Behind H-PROOF: H-PROOF promotes enzymes that facilitate the conversion of alcohol toxins into harmless substances. The product's formulation includes ingredients like dihydromyricidin (DHM), milk thistle, and B vitamins. -Target Audience and Recommendations: H-PROOF is recommended for individuals aged 35 and above, especially those who experience changes in their ability to process alcohol. The product is suitable for anyone looking to support healthy brain, liver, and body function. -Usage Guidelines: The hosts discuss the recommended dosage of H-PROOF, suggesting a full serving (two chewables) after every five drinks. The product is also suitable for those not consuming alcohol, as it contains beneficial ingredients for overall health. -Expansion Plans and New Product Launch: H-PROOF plans to launch a limited edition flavor and is working on a second vitamin product, expected to be released in the following year.-Purchase and Availability: H-PROOF is available for purchase on its website, Amazon, and is planning a national retail strategy. THE WELL DROP - Be sure to leave a review and subscribe!Follow on Instagram @thewelldrop Produced by Haynow Media
Join me in LA at the Mindfulness Expo on Sep. 23rd! Get your tickets with 15% off here. Grab your free Masterclass, 5 Keys To Making Your Menstrual Cycle Flow, and get onto our list so you never miss good info and freebies here. _________________ Welcome to season 5 of Hormonally Speaking! To kick off this season, I'm talking to Dr. Kela Smith, a hormone specialist who focuses on infertility. This is such an important area, because infertility is running rampant in many parts of the world, and the answer isn't always IVF. Dr. Smith and I deep dive into why infertility has become so common, and all the ways that we can support the body to overcome infertility naturally. We cover: -Why infertility is a symptom and not the "cause" -How stress, toxins, and food all play a role in the infertility epidemic -Utilizing functional lab tests in order to see what is going on in the gut, with hormones, and the ability to detoxify, which are all pieces of the puzzle -Why it's so imperative to get really clear about what's not serving you What I love about our discussion is that whether or not you are trying to conceive, Dr. Smith's advice is going to help improve your hormone situation. She is sharing the keys to hormone health! And Dr. Smith was kind enough to share a FREE gift with you - His and Hers Fertility Meal Plan. Dr. Kela Smith, Ph.D., DNM, DHM is a leading Holistic Integrative Fertility & Hormone Doctor, dedicated to supporting women and couples facing fertility challenges. After overcoming her own fertility struggles using the Hormone P.U.Z.Z.L.E method, it has been her mission to help others solve their infertility puzzles so they can get and stay pregnant, have a healthy happy pregnancy, and easy postpartum. An accomplished author, she also hosts The Hormone P.U.Z.Z.L.E Podcast, Solving-Infertility Summit, and Healthy Happy Pregnancy Summit. Dr. Kela's expertise also extends to guiding and inspiring future fertility experts as the lead educator at Fertility Coach University. With vast experience and dedication to holistic health, she's a renowned authority in her field. Join her in solving the infertility puzzle at www.coachkela.com. --- Support this podcast: https://podcasters.spotify.com/pod/show/christine-garvin/support
I discuss everything you need to know about Dihydromyricetin including benefits, what it is, how to use, side effects, science, and more! **NOTE** - There was a glitch around the 1:20 mark w. the sound. Only lasts about 30 seconds. Hang in there and stay for the good stuff. Sorry! New to nootropics? Check out the Nootropics Prime Course: https://holisticnootropics.com/recommends/nootropics-prime-free-module/ Download the Free Supplement Buying Guide Follow Us On Socials! Tik Tok Instagram YouTube
Kennen Sie ‚Das Wunder von Remagen‘? Ich hab‘s auch erst in der Ausstellung ‚Roads not Taken. Oder: Es hätte auch anders kommen können‘ gelernt. Anfang 45, als der II. Weltkrieg schon jahrelang tobte, gab es bei Remagen die letzte intakte Brücke über den Rhein. Die Nazis versuchten, sie zu sprengen, um den Alliierten den Weg nach Osten abzuschneiden. Es misslang und am 7. März 1945 überquerten amerikanische Truppen die Brücke, unterstützt von belgischen und englischen Soldaten. Den Rest kennen wir. Aber wieviel länger hätte der entsetzliche Krieg gedauert, wenn die Brücke doch zerstört worden wäre? Solche Fragen stellt die Ausstellung im DHM, die noch auf eine andere Weise ungewöhnlich ist: sie geht in der Geschichte zurück. Es beginnt mit 1989, der Wende - eine riesige Leinwand zeigt die feiernden Menschen auf der Mauer. Aber sie ist in bewegliche Längsstreifen unterteilt und wenn die sich drehen, zeigt sich ein ebenso riesiges Schwarz-Weiß-Foto vom Platz des Himmlischen Friedens in Peking. Dass hier die Demonstrationen brutal niedergeschlagen wurden, hatten die DDR-Bürger natürlich im Kopf. So wird die bange Frage von damals, ob wohl alles friedlich bleiben würde, nochmal aufgeworfen. Was ist, wenn sie doch schießen? Viele weitere Kipppunkte der deutschen und der Weltgeschichte werden thematisiert, immer mit möglichen Alternativen. Die Kuba-Krise, Atombombenversuche in den USA und detaillierte Bunker- und Notfallpläne für unser Land – beängstigend. Propaganda auf beiden Seiten. Die Ausstellung beginnt 1989 mit dem Sturz der DDR und endet im Jahr 1848, als in Deutschland erstmals ein demokratischer Aufbruch versucht wurde. Alles sehr einfallsreich präsentiert. Und Sie haben noch viel Zeit: ‚Roads not Taken‘ im DHM ist noch bis November 24 zu sehen! Hosted on Acast. See acast.com/privacy for more information.
YOU DO NOT WANT TO MISS THIS!!! The highly anticipated DHM x BF collab is here. This week Kody is joined by the great Teddy Diekman and Ryan McLean in a colossal podcast. We discuss international fame, the ghost, Erskineville Knife Guy, burning down the house and the football world cup. Strap in, it's a big one.
Loneliness and social isolation are known to cause several mental health issues, as the COVID-19 pandemic reminded us. This can cause long-term difficulties and seriously impact the brain and overall brain function.By studying the different biological and behavioural effects of social isolation on mice, Dr Jing Liang and her team have recently identified a promising therapeutic with the power to reverse these changes, a major development in this field.Read the original research: https://www.nature.com/articles/s41598-022-09814-5Read the Research Outreach article here
June 21, 2023 - DHM's Drew Early joined Byers & Co to talk about the upcoming Memorial Health Championship, June 29th to July 2nd at Panther Creek Country Club. The Memorial Health Championship presented by LRS, is a PGA TOUR-sanctioned event on the Korn Ferry Tour. The 72-hole competition spans four days and features 156 of the world's best-touring professional golfers. Players compete for a total purse of $1,000,000. CLICK HERE to learn more. See omnystudio.com/listener for privacy information.
Simon's correct title reads... Professor Simon Mitchell MB ChB, PhD, DipOccMed, DipAdvDHM (ANZCA), FUHM, FANZCA, Department of Anaesthesiology, University of Auckland. This clearly does not fit in the title of this episode however, it goes a LONG way to explaining why Simon is one of the top dogs when it comes to being able to pour a healthy amount of clarity over the common confusions between decompression sickness, decompression illness, and arterial gas embolism. Simon is a physician and scientist with specialist training in diving medicine and anesthesiology. He is widely published with over 150 papers or book chapters. He co-authored the 5th edition of 'Diving and Subaquatic Medicine' and has two chapters on decompression illness in the most recent edition of Bennett and Elliott. He has twice been Vice President of the Undersea and Hyperbaric Medicine Society (USA) and in 2010 received the society's Behnke Award for contributions to the science of diving and hyperbaric medicine. In the past, Simon was a naval diving medical officer and medical director of the Wesley Centre for Hyperbaric Medicine in Brisbane. He now works as a consultant anaesthetist at Auckland City Hospital, and Professor in Anaesthesiology at the University of Auckland. He provides on-call cover for diving and hyperbaric emergencies at the North Shore Hospital Hyperbaric Unit in Auckland. Simon assumed the role of Editor of Diving and Hyperbaric Medicine in January 2019. Simon's diving career has included more than 6,000 dives spanning sport, scientific, commercial, and military diving. He has been a lead member of teams that were the first to dive and identify three deep wrecks of high historical significance in Australia and New Zealand. At the time of one of these dives (2002) the 180 m depth represented the deepest wreck dive ever undertaken. He was elected to Fellowship of the Explorers' Club of New York in 2006, and was the DAN Rolex Diver of the Year in 2015. Ref: www.dhmjournal.com. (n.d.). DHM, Simon Mitchell. [online] Shearwater Shearwater dive computersDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh., is an internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 35 years of clinical experience. LaValle is best known for his expertise in performance health and integrative care with personally seeing thousands of clients over the years. He has an extensive background in natural products, lifestyle, drug/nutrient depletion, and uncovering the underlying metabolic issues that keep people from feeling healthy and vital. He has developed programs for several industries including fitness, professional sports teams and health care companies. Most recently Jim was appointed the Clinical Director of the Pro Football Hall of Fame Performance Health Program. He taught for 15 years as an appointed adjunct faculty member at the University of Cincinnati College of Pharmacy pioneering the course “Survey of Natural Medicine”, served as faculty at the College of Medicine at U.C. all the while serving as a preceptorship for both physicians and pharmacy students. He is the founder of Metabolic Code Enterprises, a cloud-based assessment tool that helps to pinpoint where the metabolic roadblocks are to person's health based on their symptom survey, lab markers, biometric and wearable data. The tool helps prioritize care for individuals using a point system to indicate areas of metabolism that are the most out of balance. The platform provides suggestions for dietary supplements, diet and other targeted lifestyle suggestions with the goal of building metabolic reserve, resiliency and vitality. In 2010, Jim developed personalized weight loss and wellness programs for LifeTime Fitness using his Metabolic Code approach for health and wellness. He and his team have also developed performance health programs for professional sports car racing, football, baseball, basketball, soccer and hockey players and teams, along with Olympic athletes. LaValle gained national recognition as National Clinician of the Year in 2012 by the Natural Products Association for his pioneering work in furthering the professional standards of integrative care. And in 2017 as Educator of the Year for American Academy of Anti-Aging Medicine. He is an appointed faculty member for the Integrative Medicine postgraduate program at George Washington University School of Health Sciences. As the Clinical Co-Chair at the American Academy of Anti-Aging Medicine, he has trained thousands of health care professionals on the value of predictive health and performance and modeling health care practices to incorporate lifestyle, diet and natural therapies as part of the health equation for Americans. He is author of more than 20 books including, “Cracking the Metabolic Code,” “Nutritional Cost of Drugs,” and his latest book, “Your Blood Never Lies”. In addition, he has authored 16 e-Books and four databases with information on a variety of topics, ranging from natural therapeutic decision tools, herb drug interactions, drug induced nutrient depletion, and professional monographs on 240 vitamin, mineral, nutraceutical and herbal compounds. He has also authored 200 articles, as well as being published in peer reviewed literature. Jim was named one of the “50 Most Influential Pharmacists” by American Druggist magazine and was one of nine Americans selected by Senator Tom Harkin, to participate in the inaugural Dietary Supplement Education Alliance & Dietary Supplement Information Bureau. As such, he is often called on by media for interviews on a variety of health topics due to his expertise and engaging style.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.17.533098v1?rss=1 Authors: Lafontaine, D. L., Zorbas, C., Soenmez, A., Leger, J., De Vleeschouwer, C. Abstract: Ribosome biogenesis is initiated in the nucleolus, a multiphase biomolecular condensate formed by liquid-liquid phase separation. The nucleolus is a powerful disease biomarker and stress biosensor whose morphology reflects its function. Here we have used digital holographic microscopy (DHM), a label-free quantitative phase contrast microscopy technique, to detect nucleoli in adherent and suspension cells. Subtle nucleolar alterations induced by drug treatment or by depletion of ribosomal proteins were efficiently detected by DHM. We trained convolutional neural networks to detect and quantify nucleoli automatically on DHM images of cultured human cells (HeLa). Holograms containing cell optical thickness information allowed us to define a novel nucleolar index which we used to distinguish nucleoli whose material state had been optogenetically modulated. We conclude that DHM is a powerful tool for quantitatively characterizing nucleoli, including material state, without any staining. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
GM GA GN Degens, Diamond Hands, and everyone in between! Welcome back to the DOOR Show! It's the same old Show, but it has a few new feels. Cap kicks things off with the 1st segment of the day, Word on the Chain, and breaks down the latest news from around the world of Web3 & beyond. For the 2nd segment of the day, DOORkeepers, Cap discusses the latest DHM updates and alpha soon to be hitting the blockchain. Get ready for an absolutely loaded Show filled with conversations you won't find anywhere else! Thanks for stopping by! Be a friend, tell a friend, and let's "DOOR" together! Don't forget, right now is the perfect time to flex those Diamond Hands! Diamond Hand Media Group Linktree: https://linktr.ee/diamondhandmediagroup Coffee Labs Website: https://www.coffeelabs.com/ (Enter code "DMNDHandRadio" at checkout for 10% OFF your order) (Free shipping on orders of $50+)
Jubiläum bei Netzklatscher - Die 50. Folge! Grund genug, zumindest zwei Drittel der Originalbesetzung an den Start zu bringen. Clemens ist mal wieder im Ausland, der Klassiker. Im ausführlichen Jahresrückblick sprechen Marcel und Lukas über das wohl heftigste Roundnet-Jahr ever: Masters, DHM, DM, EM, WM und auch noch ein eigenes Roundnet-Festival. Kein Wunder, dass die Folge Überlänge hat.
From BMP/DDB, AMV/BBDO and Mother to Campbell Doyle Dye, DHM and LOVE or FEAR, Dave Dye has been behind some of the world's most amazing advertising campaigns in his 40-year career. A creative leader, Dave also runs one of the advertising industry's most loved podcasts 'Stuff from the Loft' where it's not unheard of to hear 2-3 hour long interviews with advertising royalty. In this show, Dave discusses the art of leadership, using Tim Delaney and Alan Parker as examples. He urges the ad industry to get back to solving business problems, and why it's important to explain the creative process to clients. Dave's favourite piece of work, the emotion of creativity, impostor syndrome, how D&ADs have changed, the fossil fuel addiction rabbit hole, keeping podcasting natural, Dave's white whale, Dave Trott's theory of jingles and new technology that works! And Arsenal...Dave's beloved Arsenal. Incidental music by Music_Unlimited from Pixabay That link to the report on open plan workspaces:https://royalsocietypublishing.org/doi/full/10.1098/rstb.2017.0239 Learn more about your ad choices. Visit megaphone.fm/adchoices
Happy Monday Degens, Diamond Hands, & everyone in bewteen! Welcome back to the DOOR Show and into the first Episode of the week! Cap kicks things off with the 1st segment of the day, Word on the Chain, and breaks down the hottest topics from around the world of Web3 & beyond. For the 2nd segment of the day, Cap welcomes not 1 but 4 legends onto the DOOR Show! You may have noticed that DHR turned into DHM, and it's time that you all find out who's behind the updates! There're massive announcements on the horizon and Episode #65 is only the beginning of it all. Get ready for an absolutely loaded Show filled with conversations you won't find anywhere else! Thanks for stopping by! Be a friend, tell a friend, and let's "DOOR" together! Don't forget, right now is the perfect time to flex those Diamond Hands! Diamond Hand Media Group Twitter: https://twitter.com/TheDHMGroup Cappin Colt's Twitter: https://twitter.com/CappinColt Coffee Labs Website: https://www.coffeelabs.com/ (Enter code "DMNDHandRadio" at checkout for 10% OFF your order) (Free shipping on orders of $50+)
Before getting into teaching full-time, Gibson Biddle was VP of Product at Netflix and CPO at Chegg (a textbook rental and homework help company). He now spends his days speaking, writing, and hosting workshops on product leadership, strategy, and culture. There are very few people in the world who’ve worked with, and had an impact on, more product managers.—Thank you to our sponsors for making this episode possible:• Flatfile: flatfile.com/lenny• Coda: coda.io/lenny• PostHog: posthog.com/lenny—In this episode, we cover:1) Gibson’s career path to VP of Product at Netflix, CPO at Chegg, and eventually teaching full-time.2) The DHM model: The 3 factors of a product strategy for consumer companies, how you can apply it to your product strategy, and how Gibson used this model for decisions made at Netflix.3) Five mini case studies of the DHM model that could be applied to Netflix’s strategy.4) The GEM prioritization model: What are the 3 areas a company can optimize on? What is the fundamental misalignment that destroys startups? 5) How could you start building your product strategy muscle, even when you’re only two weeks into your new role?6) Building your personal board of directors.7) What does it take to become a CPO someday?8) What specifics in a daily routine separate a good product manager from a great product manager?9) What’s the one piece of advice Gibson has for product managers in their early career?—Where to find Gibson:• Ask Gib Product Newsletter: https://askgibs.substack.com/• Gibson’s baby website: www.gibsonbiddle.com• Intro to product strategy: https://gibsonbiddle.medium.com/intro-to-product-strategy-60bdf72b17e3 Get full access to Lenny's Newsletter at www.lennysnewsletter.com/subscribe
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh., is an internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 35 years of clinical experience. LaValle is best known for his expertise in performance health and integrative care with personally seeing thousands of clients over the years. He has an extensive background in natural products, lifestyle, drug/nutrient depletion, and uncovering the underlying metabolic issues that keep people from feeling healthy and vital. He has developed programs for several industries including fitness, professional sports teams and health care companies. Most recently Jim was appointed the Clinical Director of the Pro Football Hall of Fame Performance Health Program. He taught for 15 years as an appointed adjunct faculty member at the University of Cincinnati College of Pharmacy pioneering the course “Survey of Natural Medicine”, served as faculty at the College of Medicine at U.C. all the while serving as a preceptorship for both physicians and pharmacy students. He is an appointed faculty member for the Integrative Medicine postgraduate program at George Washington University School of Health Sciences. As the Clinical Co-Chair at the American Academy of Anti-Aging Medicine, he has trained thousands of health care professionals on the value of predictive health and performance and modeling health care practices to incorporate lifestyle, diet and natural therapies as part of the health equation for Americans. He is author of more than 20 books including, “Cracking the Metabolic Code,” “Nutritional Cost of Drugs,” and his latest book, “Your Blood Never Lies”. In addition, he has authored 16 e-Books and four databases with information on a variety of topics, ranging from natural therapeutic decision tools, herb drug interactions, drug induced nutrient depletion, and professional monographs on 240 vitamin, mineral, nutraceutical and herbal compounds. He has also authored 200 articles, as well as being published in peer reviewed literature.
Republican US Senate candidate Ibra Taher interview: https://ibrahimtaher.com/ Kate Brown still least popular Gov in nation: https://www.wweek.com/news/2022/04/28/new-polling-shows-gov-kate-browns-popularity-remains-at-nations-lowest-level/ Republican hopes in OR are real according to DHM poll: https://www.theepochtimes.com/oregon-voters-in-a-sour-mood-ahead-of-may-17-primaries_4432177.html
A grab bag of stuff gleaned from the DHM crew @ SHM in Nashville. All sources in this episode can be found in the April 2022 CKC dispatch e-mail dated 4/19/2022. | 00:00 Intro | | 00:39 TOC | | 01:27 HFrEF management | | 02:42 AC monotherapy in stable CAD+Afib | | 03:28 Upper GI bleed management | | 04:15 ID updates (GNR Bacteremia and MRSA) | | 05:22 Ascites, SBP, HRS in Cirrhosis | | 06:23 Post-op complications in elective surgery done peri-COVID | | 07:00 Peri-op LMWH bridging | | 08:03 Midodrine and vasovagal syncope | | 09:05 Closing | [The appearance of external hyperlinks does not constitute endorsements by UCSF of the linked websites, or the information, products, or services contained therein. UCSF does not exercise any editorial control over the information found therein, nor does UCSF make any representation of their accuracy or completeness.]
Dr. David & Stephanie Herzog are the founders of David Herzog Ministries. Their passion is to live in the Presence and Glory of God through intimacy with God in the Holy Spirit, to equip believers to do the greater works and to bring the gospel to as many souls as possible in every nation of the world. Dr. David and Stephanie have been in full time ministry for over 25 years since 1991 and have lived in the U.S as well as in France with their family as missionaries. Both are graduates of Christ For the Nations Institute (since 1992) with an Associate of Practical Theology Degree and in 2014 David received his Doctorate. (David also has a masters degree) During that time they have ministered in over 50 nations and held both large evangelistic campaigns as well as hosting and speaking in conferences, churches, seminars, stadiums and outreaches seeing incredible healings, miracles and deliverances confirming the Gospel message. about_2Dr. David and Stephanie have had multiple opportunities to counsel and pray with Presidents and Vice Presidents, Prime Ministers and other government leaders as well as those in the media and entertainment industry. For several years they hosted a TV Show called, “The Glory Zone” and have appeared on numerous television interviews both Christian and Secular. David is the author of 8 books including “Glory Invasion” and Stephanie is the author of “God is your Matchmaker” and they are the founders of DHM. SPREADING THE GREATER GLORY IS how they live their life, through ministering in stadiums, conferences, revivals and outreaches all over the world in every continent.
Charlie Shamp is the Co-Founder and President of Destiny Encounters International. He is a sought after international key note speaker. He has been commissioned by Heaven as a Prophet to bring healing and revival in the nations. He has ministered both nationally and internationally with radical demonstrations of faith seeing lives transformed through the power of the Holy Spirit. Prophet Charlie has predicted major world events... with pinpoint accuracy. These include presidential elections, catastrophic natural disasters, revealing government corruptions and exposing terrorism plots. Charlie has been uniquely gifted by God to see and speak accurately into the spirit realm coupled with a ministry of miracles, signs and wonders releasing transformation into churches and cultures worldwide. Through God's divine gifting, Charlie has been given the ability to see the prophetic potential in people and motivate them to cultivate the gifts and talents that often lie dormant within them. He uses the word of God and the power of the prophetic to unearth the hidden treasure God has placed in the believer revealing Heaven's divine plan for their individual lives. Through the Holy Spirit, God has used Charlie to motivate many to move beyond mediocrity and embrace excellence and greatness. Charlie's heart is to empower and equip the Body of Christ with supernatural insight regarding what God has to say about their destiny and to advance the Kingdom of God in the Earth. People all over the world have been brought to the sacred truth that in Christ they are no longer victims, but overcomers in this life through his ministry. Dr. David & Stephanie Herzog are the founders of David Herzog Ministries. Their passion is to live in the Presence and Glory of God through intimacy with God in the Holy Spirit, to equip believers to do the greater works and to bring the gospel to as many souls as possible in every nation of the world. Dr. David and Stephanie have been in full time ministry for over 25 years since 1991 and have lived in the U.S as well as in France with their family as missionaries. Both are graduates of Christ For the Nations Institute (since 1992) with an Associate of Practical Theology Degree and in 2014 David received his Doctorate. (David also has a masters degree) During that time they have ministered in over 50 nations and held both large evangelistic campaigns as well as hosting and speaking in conferences, churches, seminars, stadiums and outreaches seeing incredible healings, miracles and deliverances confirming the Gospel message. about_2Dr. David and Stephanie have had multiple opportunities to counsel and pray with Presidents and Vice Presidents, Prime Ministers and other government leaders as well as those in the media and entertainment industry. For several years they hosted a TV Show called, “The Glory Zone” and have appeared on numerous television interviews both Christian and Secular. David is the author of 8 books including “Glory Invasion” and Stephanie is the author of “God is your Matchmaker” and they are the founders of DHM. SPREADING THE GREATER GLORY IS how they live their life, through ministering in stadiums, conferences, revivals and outreaches all over the world in every continent.
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh, is an internationally recognized Heart and Immune Health Expert with over 35 years of clinical experience. He is a clinical pharmacist, author, board-certified clinical nutritionist and founder of Metabolic Code Enterprises, Inc. I highly recommend his book, Your Blood Never Lies: How to Read a Blood Test for a Longer, Healthier Life, and his groundbreaking bestseller, Cracking the Metabolic Code: 9 Keys to Optimal Health. Our topic this week is: Your HEART & IMMUNE Health Strategy this season! Hopefully, we can also take a few calls. Mr Lavalle's appearance has been arranged by our wonderful sponsor, Kyolic Aged Garlic. This links to their new Omeg-AGE formula and this one to the Immune Product that Jim discussed. To review all products, CLICK HERE. Charity Navigator Rec Cross Ukraine page
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh, is an internationally recognized Heart and Immune Health Expert with over 35 years of clinical experience. He is a clinical pharmacist, author, board-certified clinical nutritionist and founder of Metabolic Code Enterprises, Inc. I highly recommend his book, Your Blood Never Lies: How to Read a Blood Test for a Longer, Healthier Life, and his groundbreaking bestseller, Cracking the Metabolic Code: 9 Keys to Optimal Health. Our topic this week is: Your HEART & IMMUNE Health Strategy this season! Hopefully, we can also take a few calls. Mr Lavalle's appearance has been arranged by our wonderful sponsor, Kyolic Aged Garlic. This links to their new Omeg-AGE formula and this one to the Immune Product that Jim discussed. To review all products, CLICK HERE. Charity Navigator Rec Cross Ukraine page
DHM is a hangover cure for smart biohackers who like to imbibe, but it's well worth supplementing even if you don't drink to excess...I break down everything you need to know about Dihydromyricetin and why it belongs in the cabinet of every self-respecting boozing biohacker. I also share how I make and enjoy "Psilocybin Beer” - yes, that's a thing (you must try)!2:44 Storytime5:00 If You EVER Drink Get DHM8:45 Anti-Intoxicant10:45 Scientific Research & Origin11:21 Vs Fatty Liver Disease14:02 Vs Alzheimer's15:00 Treatment of Memory Loss16:09 Interactions with Gut Microbiota17:08 Vs Alcoholism19:35 Vs Immune/Inflammatory-Related Diseases20:40 Vs Diabetes21:52 Vs Acute Lung Injury22:32 Vs Endothelial Dysfunction23:13 Vs Cancer24:52 Performance Enhancement of Exercise at Altitude25:51 A Rapid Antidepressant26:45 Mechanism of Action27:50 Experiential35:30 Sources37:07 Cofactors40:00 Usage and Dosage42:04 Hangover Recovery Stack45:50 Side Effects & Risk47:03 Psilocybin Beer49:45 Conclusion
To watch this as a video Download it and play it from the Downloads section in the Castbox app on your device.DHM is a hangover cure for smart biohackers who like to imbibe, but it's well worth supplementing even if you don't drink to excess...I break down everything you need to know about Dihydromyricetin and why it belongs in the cabinet of every self-respecting boozing biohacker. I also share how I make and enjoy "Psilocybin Beer” - yes, that's a thing (you must try)!2:44 Storytime5:00 If You EVER Drink Get DHM8:45 Anti-Intoxicant10:45 Scientific Research & Origin11:21 Vs Fatty Liver Disease14:02 Vs Alzheimer's15:00 Treatment of Memory Loss16:09 Interactions with Gut Microbiota17:08 Vs Alcoholism19:35 Vs Immune/Inflammatory-Related Diseases20:40 Vs Diabetes21:52 Vs Acute Lung Injury22:32 Vs Endothelial Dysfunction23:13 Vs Cancer24:52 Performance Enhancement of Exercise at Altitude25:51 A Rapid Antidepressant26:45 Mechanism of Action27:50 Experiential35:30 Sources37:07 Cofactors40:00 Usage and Dosage42:04 Hangover Recovery Stack45:50 Side Effects & Risk47:03 Psilocybin Beer49:45 Conclusion
-Due to local DHM protocols, all players who tested positive for COVID last week will have to wear masks tonight against the Badgers -Whatever thoughts you have on that, it's still Nebraska's first game since early last week, and we'll see how they respond from time off, from Kobe Webster's accountability comments, and with masks onShow sponsored by GANA TRUCKING Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
SHR # 2809:: DHM: A Deeper Dive plus Magic Beyond Coffee - Dr. Alexis Cowan, Ph.D. - James Beshara - In 2020 I did a show about DHM the anti-hangover drug that helped people who were metabolically deranged. This made me wonder what else this compound could do. Turns out, as suspected, it does a LOT more. PLUS Coffee destroyed my gut and my health. I struggled with giving up coffee for years. The hard part of giving up coffee was the bran fog. This nootropic changed all of that and now I'm no longer dependent on coffee. Three months and no coffee!
TIMESTAMPS00:02:50 - Cold Open00:04:25 - GSH Introduction00:05:05 - Show Open 00:11:40 - Flight Deck: Male Lizzo00:33:40 - The Story Continues: Purple Haze to DHM00:51:05 - GSTv01:12:50 - The Music Behind The Story01:20:15 - Lyric Video: LSK01:39:30 - TSC: DHM | Ch. 2 - Buckhead Livin'01:57:45 - Tell Me Something Good: God Body Bingo and Megan Pete, THEE Graduate EPISODE PLAYLISTIntro MedleyRock My World x Purple HazeWhiteGirl Remix x Purple HazeWhat's Up Remix x DHM ft YNOTTWe Runnin' Thangs x C.O.D. DecaturboyMusic ft Hitman SamShut Up x Purple Haze ft Lil' GreenWe So Fly x C.O.D. DecaturboyMusic ft P. Henry Trotter IV and BTCalifornia Roll x C.O.D. DecaturboyMusic ft Buckhead ReddGuarantee x C.O.D. DecaturboyMusic ft P. Henry Trotter IV and TrillaSpoil You x C.O.D. DecaturboyMusic + P. Henry Trotter IVGo Hard x C.O.D. DecaturboyMusic + P. Henry Trotter IVI Do It Cause x C.O.D. DecaturboyMusic + P. Henry Trotter IVRed Cup x C.O.D. DecaturboyMusic + P. Henry Trotter IVResume x C.O.D. DecaturboyMusic + P. Henry Trotter IVBrand New x C.O.D. DecaturboyMusic + P. Henry Trotter IV
Welcome to the Rocky Mtn Mixdown podcast where we discuss and document the making of the Colorado music scene. Episode 17 features School of Rock Broomfield, one of our favorite studio clients. We've had a blast hosting SoR Broomfield showcase gigs and live stream shows, and we're happy to introduce School of Rock Broomfield's fearless leader and branch owner, Jennifer Moriarta, along with instructor and musician Derek Arnold, and student musician, Steve Koenig. Listen in as we discuss the role School of Rock plays in infusing the local music scene with new musicians of all ages, genders, backgrounds and abilities. Find out how Jennifer transitioned from working in Silicon Valley to running School of Rock Broomfield and working with musicians all day everyday. Hear what it's like to work and play at School of Rock, and all the local venues that host SoR shows. You can find the Rocky Mtn Mixdown podcast on Spotify, Apple Podcasts, Google Podcasts, and at doghousemusic.com/rockymtnmixdown. Thank you to our DHM engineers John Remington and Ty Galloway for producing this episode. EPISODE LINKS School of Rock Broomfield | Instagram | Facebook | YouTube Dog House Music Studios | Website | Instagram | Facebook | YouTube Liz Vasko | Instagram Cody Crawford | Instagram WHO WE'RE LISTENING TO THIS WEEK Derek | WizKid Jennifer | Liz Phair Steve | Romstein Liz + Cody | Pink Fuzz Liz | Gillian Welch Cody | Shady Oaks Cody | Valerie June --- Send in a voice message: https://anchor.fm/rockymtnmixdown/message Support this podcast: https://anchor.fm/rockymtnmixdown/support
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh, is an internationally recognized Heart and Immune Health Expert with over 35 years of clinical experience. He is a clinical pharmacist, author, board-certified clinical nutritionist and founder of Metabolic Code Enterprises, Inc. I highly recommend his book, Your Blood Never Lies: How to Read a Blood Test for a Longer, Healthier Life, and his groundbreaking bestseller, Cracking the Metabolic Code: 9 Keys to Optimal Health. Our topic this week: A Multi-Tasking Strategy for Immune-Heart-Bone Health for this Fall & Winter. We may be able to take a few calls. Mr Lavalle's appearance was arranged by our sponsor, Kyolic Aged Garlic. This links to their wonderful Omeg-AGE formula.
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh, is an internationally recognized Heart and Immune Health Expert with over 35 years of clinical experience. He is a clinical pharmacist, author, board-certified clinical nutritionist and founder of Metabolic Code Enterprises, Inc. I highly recommend his book, Your Blood Never Lies: How to Read a Blood Test for a Longer, Healthier Life, and his groundbreaking bestseller, Cracking the Metabolic Code: 9 Keys to Optimal Health. Our topic this week: A Multi-Tasking Strategy for Immune-Heart-Bone Health for this Fall & Winter. We may be able to take a few calls. Mr Lavalle's appearance was arranged by our sponsor, Kyolic Aged Garlic. This links to their wonderful Omeg-AGE formula.
Forever Young Radio Show with America's Natural Doctor Podcast
James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh., is an internationallyrecognized Heart and Immune Health Expert with over 35 years of clinical experience. He is a clinical pharmacist, author, and board-certified clinical nutritionist. Jim joins us today to discuss a unique “Multi-Tasking Strategyfor Immune-Heart-Bone Health this Fall: Kyolic Omega A-G-E.
Freunde des guten Geschmacks, wir haben wieder hohen Besuch in unserer Podcastschüssel, nämlich niemand geringeres als die erste Arschstilpreisträgerin: Giuli aus Braunschweig! Wie reden über die vergangenen Qualis in Hannover, Regensburg und Berlin und geben euch schonmal einen kleinen Vorgeschmack auf die zwei letzten Qualis, die DHM und was im November für CHUs anstehen. Danke an die patreons, die uns die Treue halten! Giuli, Vici, Ecki, Zabrina, Yannick Kuss geht raus! :* Ihr wollt auch? Unterstützt uns! PayPal: paypal.me/kornohneflakes Patreon: www.patreon.com/kornohneflakes
Endlich wieder CHU, endlich wieder Podcast. Und da wo die CHUs etwas abgespeckt daher kommen, legen wir noch einen drauf: Wir haben Celine zu Gast. Sie ist zusammen mit Johannes Aktivensprecherin des DAR. Also die geballte Kompetenz für unsere erste Folge nach mehr als einem Jahr! Es geht um die Qualis, die noch stattfinden werden, die DHM und das vergangene Wochenende, an dem Nürtingen das erste CHU seit 18(!!!) Monaten veranstaltet hat. Liebe geht raus an unsere Patreons :* Giuli, Vici, Ecki, Zabrina, Yannick Ihr wollt uns auch unterstützen? patreon.com/kornohneflakes paypal.com/kornohneflakes
Driven by the Delta variant, COVID-19 trends are rising at an alarming rate statewide. Will Bauer of Nebraska Public Media News has more on this week's data update from the Department of Health and Human Services.On the other hand, the percent of positive tests dropped 1.5 percent this week. About 7 percent of tests taken came back positive this past week.Hospitalizations increased to 314 beds in Nebraska. That's just more than 7 percent of the state's hospital beds. However, hospitals in Lincoln and Omaha have said they are close to capacity because of regular procedures. If the previous DHM was in place, 10% would trigger restrictions. Currently, no DHM is in place.
"Nếu những ai xuống hỏa ngục thì họ vĩnh viễn đoạn tuyệt với Thiên Chúa. Vậy Chúa có quá hà khắc, không thương xót những linh hồn ấy?" Chuyên mục 'Giải đáp thắc mắc cho người trẻ Công giáo' - Tập 2
HLTV Confirmed teams up with smooya to discuss the team, roster move, highlight, match, disappointment, and surprise that defined the first half of 2021. Also discussed is smooya career in Movistar Riders, another scandal involving HUNDEN, Astralis going 6-man, peacemaker joining Complexity, as well as fnatic & Liquid rumors. ➡️ Connect with us: https://twitter.com/HLTVconfirmed
As you may be aware the focus of brain health has become more important. Not only are we seeing an uptick in disorders such as autism and ADHD; we are also experiencing population that is living longer. Due to the modern medicine, lifespan is increasing, however that might be coupled with declining cognitive function and increased brain disease risk. Understanding neuroinflammation, the underpinning of what drives brain disorders is important if we are going to be able to solve brain dysfunctions. In today's episode I welcome on a legend in in the functional medicine and regenerative medicine space Jim LaValle R. Ph. CCN. He has a decorated background in natural medicine functional medicine and regenerative medicine. His unique training in the field of pharmacy, botany, nutrition and naturopathy and over 40 years of clinical and teaching experience has led him to have a firm grasp of how to help people deal with chronic inflammatory conditions. I think you'll quickly notice that he is beyond exceptional at what he does. He is author of over 20 books you can find out more about him on website www.jimlavalle.com. In this episode we dive deeply into the topic of Metflammation; specifically neural inflammation. This is what happens when the brain is upregulated and as they say on fire. This takes place in conditions such as ADHD, Alzheimer's disease, autism, anxiety, and many other disorders. In this episode we cover: Mentors Books of Influence Neuroinflammation Core Concepts Glial Cell Activation Excitotoxins Metflammation Drivers of Inflammation CIRS: Chronic Inflammatory Response Syndrome Lab testing Synapsin and Other Treatments More about Jim: James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh. N.D.(trad) is an internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 35 years of clinical experience. LaValle is best known for his expertise in performance health and integrative care with personally seeing thousands of clients over the years. He has an extensive background in natural products, lifestyle, drug/nutrient depletion, and uncovering the underlying metabolic issues that keep people from feeling healthy and vital. He has developed programs for several industries including fitness, professional sports teams and health care companies. Most recently Jim was appointed the Clinical Director of the Pro Football Hall of Fame Performance Health Program. --- Send in a voice message: https://anchor.fm/adam-rinde/message Support this podcast: https://anchor.fm/adam-rinde/support
"Là người trẻ, con chẳng hiểu thế nào là sống có ý nghĩa. Trong khi đó, con nghe nhiều người nói ý nghĩa cuộc sống là điều quan trọng. Vậy làm sao đạt được điều ấy?" Chuyên mục 'Giải đáp thắc mắc cho người trẻ Công giáo' - Tập 2
Fancy some stand-up comedy on the subject of DIRTY HARRY? Well, strap yourself in for a roast by the industry’s finest – the one and only – Jerry Reiser! Also for your enjoyment, yet more analysis on the movie and its characters, insight from other reviewers, and more delicious B-Roll unearthed from DHM vaults. Thanks …
Jack and Mayor Gaylor Baird talk the new DHM, which includes an end to the mask mandate, plus the LPD Chief search and the new city council makeup.
I will be brutally honest and say that today's episode is probably the most powerful and important episodes to date. My guest today is someone who has changed my life, my wife Sarah's life, many of my friends lives and has helped millions of people all around the world. It's time to forget pretty much everything you knew about food and nutrition and look at eating from a scientific standpoint. That's where my guest today comes in. Dr. Nartey is the founder of symptometry, originator of root cause therapeutics and author of multiple books. Dr. Maxwell Nartey has helped countless people heal from chronic and acute diseases by removing known hindrances from the cells, from DNA, from blood and from the lymphatic system. He does this using a simple, but scientific 19-step method to nourish the cells, to maintain the body's electrical balance, and to boost the positive energy (nurturing) in the ailing individual's environment. Originally trained as a Doctor of Homoeopathic Medicine and a Doctor of Natural Health, Dr. Nartey is now also a current Fellow of the British Institute of Homoeopathy, a Doctor of Symptometry, therapeutic scientist, a researcher and a Licensed Symptometrist. He is the inventor of root cause therapeutics, correlation diagnostics, symptoms as codes, deconstructive research, therapeutic science and applied quantum physics. Dr. Nartey, DHM, NHD founded Symptometry in 1992. After fourteen years of laboratory research and applicability, he made root cause therapeuticsTM available to the public. Then, in 2010, he established the American School of Symptometry to train additional Doctors of Symptometry. The Board of Symptometry fully accredited American School of Symptometry in 2011. As Symptometry is the first entirely science-based therapeutics that both identifies the ROOT CAUSE of a disease in the individual and uses all natural therapeutic products to remove it, licensed symptometrists and authorised coaches are able to help those battling: genetic and autoimmune diseases viral and chronic diseases cancer, diabetes, heart disease, loss of mobility and other diseases triggered by diet & lifestyle habits Connect with Dr. Nartey: https://amsos.org/ Connect with Me: https://www.kinetikfitness.co.uk/ https://www.instagram.com/aliwestcoach/?hl=en https://www.facebook.com/thekinetikfitnessshow https://www.youtube.com/channel/UCR9Oe_kjET63UrlCyIXlsnA Support the Kinetik Fitness Show with a donation to my Crowd Funding campaign: https://www.justgiving.com/crowdfunding/aliwestpodcastsupport Join Our Mailing List For Daily Fat Loss Tips: https://mailchi.mp/ali-west/email-capture Book a coaching call with me: https://westcoachingconsultcall.as.me/consultation Sponsor Discounts: Get 5% off Red Light Rising Products Use code: ALIWEST: https://redlightrising.co.uk/shop-all/ Get 15% off Shilajit use code: aliwest: https://www.purehimalayanshilajit.com/buy-shilajit/ Get 20% off your Mudho Health DNA Testing Kit use code ALDNA: https://muhdo.com/ --- Send in a voice message: https://anchor.fm/thekinetikfitnessshow/message Support this podcast: https://anchor.fm/thekinetikfitnessshow/support
The theme of this week's Product Thinking Podcast is culture, and Melissa Perri's guest is Gibson Biddle, author of the “Ask Gib” product newsletter. Gibson is dedicated to teaching product strategy and culture both in and outside of the classroom. He joins Melissa to discuss the importance of having a good organizational culture, and how that affects strategy. Here are some key points you'll hear Melissa and Gibson talk about in this episode: The product leader's job is to delight customers in hard-to-copy, margin-enhancing ways (DHM). [3:18] How Netflix developed their high-level strategy for personalization. [8:47] Gibson's experience with managing the product team as VP of Product Management at Netflix. Every product leader who worked for him was expected to have clear, defined strategies for their teams. [12:39] The failure of Project Griffin. [20:37] Building a culture where everyone is on the same page about making the best choices for the business is difficult, but not impossible. One key practice is context over control; ensure that everyone understands the context that the business is operating in. [25:54] “At the end of the day, people are not there forever but the culture is; the culture describes the [company's] values and the values describe the skills and behaviors of everyone in the building,” Gibson tells Melissa. “At our quarterly meetings, we would discuss strategy, but we would also learn to form good judgment. This is what the culture is about; helping individuals make great decisions about products.” [29:41] "Culture is all about who you hire… who you promote- every time someone was promoted to director or VP there was a celebration because it was about them being a culture carrier, them living the Netflix culture. And [when you would] let people go, they might demonstrate amazing results, but they were living outside of Netflix's values,” Gibson shares. [38:46] Strategy is important when starting a product organization, but it's ok if half of it fails. It's a process and a bunch of hypotheses that you need to learn from. [43:46] Resources Gibson Biddle on LinkedIn | Twitter GibsonBiddle.com
The theme of this week's Product Thinking Podcast is culture, and Melissa Perri's guest is Gibson Biddle, author of the “Ask Gib” product newsletter. Gibson is dedicated to teaching product strategy and culture both in and outside of the classroom. He joins Melissa to discuss the importance of having a good organizational culture, and how that affects strategy. Here are some key points you'll hear Melissa and Gibson talk about in this episode: The product leader's job is to delight customers in hard-to-copy, margin-enhancing ways (DHM). [3:18] How Netflix developed their high-level strategy for personalization. [8:47] Gibson's experience with managing the product team as VP of Product Management at Netflix. Every product leader who worked for him was expected to have clear, defined strategies for their teams. [12:39] The failure of Project Griffin. [20:37] Building a culture where everyone is on the same page about making the best choices for the business is difficult, but not impossible. One key practice is context over control; ensure that everyone understands the context that the business is operating in. [25:54] “At the end of the day, people are not there forever but the culture is; the culture describes the [company's] values and the values describe the skills and behaviors of everyone in the building,” Gibson tells Melissa. “At our quarterly meetings, we would discuss strategy, but we would also learn to form good judgment. This is what the culture is about; helping individuals make great decisions about products.” [29:41] "Culture is all about who you hire… who you promote- every time someone was promoted to director or VP there was a celebration because it was about them being a culture carrier, them living the Netflix culture. And [when you would] let people go, they might demonstrate amazing results, but they were living outside of Netflix's values,” Gibson shares. [38:46] Strategy is important when starting a product organization, but it's ok if half of it fails. It's a process and a bunch of hypotheses that you need to learn from. [43:46] Resources Gibson Biddle on LinkedIn | Twitter GibsonBiddle.com
Jack and Jeff talk upcoming big events in the city and relaxed restrictions with the latest DHM, plus what's happening this weekend.
Forever Young Radio Show with America's Natural Doctor Podcast
We have a great show planned for you today, for years, doctors, nutritionists, and even the American Heart Association have encouraged people to consume more omega-3 fatty acids, primarily in the form of fish or fish oil supplements. But as beneficial as fish oil can be, there may be a better way to protect your heart. According to evolving research, adding Aged Garlic Extract (AGE) to your fish oil supplement is an easy and effective way to level up your heart smart strategy. Today we will take a closer look at how these nutrients work in tandem to help support your cardiovascular health. Joining us is: James B. LaValle, R.Ph., C.C.N. M.T. DHM, DHPh., is an internationally recognized Heart and Immune Health Expert with over 35 years of clinical experience. He is a clinical pharmacist, author, and board-certified clinical nutritionist. Jim joins us today to discuss a new “Heart Smart Strategy: Kyolic Omega A-G-E. www.Kyolic.com
Nile Rodgers has seen and done it all. He has collaborated with the world's top music stars including Madonna, David Bowie and Duran Duran and Daft Punk. The Chic Organisation created by Nile and music partner Bernard Edwards created a string of monster pop hits between 1977 and 1983, when they wrote and produced eight Chic albums, two for Sister Sledge, along with one each for Diana Ross, Debbie Harry, Johnny Matthis, and Sheila B and Devotion. Everybody knows at least a dozen Nile Rodgers songs, and who can say that these days?In 1981 he worked with a little known Australian band, an “opening act” in Nile's words, that he discovered while watching another collaboration of his at the time, the Canadian band Spoons. After meeting the band backstage after that show, Nile was delighted to find out that this band and its extremely charismatic singer warmed up their live show by singing their own version of Yum-Yum, a song from his solo album Adventures in the Land of Good Grooves. The bond was established for Rodgers' first real 80s pop collaboration: what would become the monster smash hit Original Sin by INXS. As with much of Nile's career, one thing led to another. ‘Original Sin' was much admired by Duran Duran who then requested he work with them on the next stage of their career and musical transformation. In our conversation, Nile tells me what it was that he so enjoyed about working with Duran Duran and how it became a partnership over a longer period of time (across both the Arena album, the 1986 classic Notorious and then Astronaut after the band's reformation as a five piece). How does a virtuoso player have such a knack for a hit? Part of Nile's secret sauce is his self-made belief systems, including the ‘DHM'. The Deep Hidden Meaning. It was the DHM that connected Nile deeply with the lyrics to Original Sin (which he tweaked to “dream on white boy, dream on black girl” to reflect the story of Beverly and Bobby (his mother and stepfather). At the centre of his belief system though, is work. A work ethic that has seen Nile (in his own words) have more failures than successes. Yet the failures mattered too. For one thing, his solo work was admired by Bowie and, as mentioned, INXS. But once he'd worked with Bowie, he knew things would be different no matter how successful the outcome. Nile's virtuosity, self-made belief systems and work ethic paid dividends commercially for almost every artist he and the Chic Organisation worked with (particularly up to the mid-80s) and in many cases helped boost their careers. But here's the thing...Nile's job description (in his own words) is problem solver...whether it's helping shape the big vision or tweaking minor but critical detail (that Original Sin lyric for example). Someone counted that he has worked on 18,585 recordings, which even for Nile Rodgers sounds unfeasible. And that audit doesn't include his work pre-Chic! How can that even be possible? It is because Nile continues to be a serial collaborator, a “worker bee” and one very effective problem solver. Listen in and find out some of his working secrets and those great little stories. Many thanks to Andrew James Johnson for edits and original music and Mick Clarke for the cover art, as everSupport the show (https://www.songsommelier.com)
This week's episode of "Straight Talk" examines the 2021 "State of the Economy" report with guests, Andrew Hoan, CEO of the Portland Business Alliance, John Tapogna, president of ECONorthwest, and Michelle Neiss, president of DHM research. "I would phrase this really simply as 'fire and ice,'" said Andrew Hoan. "We have had historic wildfires. We just went through historic snow and ice storms. In between it all, the pandemic, ongoing political violence, a layering of crises that has impacted the region much differently than the rest of the nation," he said. ECONorthwest's John Tapogna described the decline in the regional economy. "We're down 15% and it's a very unusual recession caused by something outside the economy, a public health crisis that has created tremendous inequities," he said. "It's very disproportionately impacting lower income households, small businesses and leaving other parts of the economy untouched."
SHR # 2619 :: Super Humans: Nathan "Hitman" Heaney The Pride Of Stoke - The Super Human Nation is made up of some of the most interesting people in the world. Nathan Heaney is one of them. Hear his story about how he is climbing the ranks of professional boxing in the UK undefeated. Learn about his unique style of training and his love if physical culture. Beat the hangover before it even shows up with DHM at http://shrnetwork.biz/dhm .
SHR # 2619 :: Super Humans: Nathan "Hitman" Heaney The Pride Of Stoke - The Super Human Nation is made up of some of the most interesting people in the world. Nathan Heaney is one of them. Hear his story about how he is climbing the ranks of professional boxing in the UK undefeated. Learn about his unique style of training and his love if physical culture. Beat the hangover before it even shows up with DHM at http://shrnetwork.biz/dhm .
What all goes into producing a Country Music Video? The Deer Society crew sits down with Michael Austin to discuss some highlights from their recent DHM video shoot and provide insight on what's to come for the DHM platform!
Jack and the mayor talk the passing of LPD Investigator Mario Herrera, COVID-19 issues, moving through DHM phases, and enforcing the mask mandate.
Vom Buchdruck über Presse und Rundfunk bis zum Smartphone: Medien sorgen stets dafür, dass sich neue Formen von politischer Öffentlichkeit ausbilden. Kritik und Debatten am Wandel bleiben da nicht aus. Eine neue Ausstellung im DHM thematisiert den Zusammenhang von Medien, Politik und Öffentlichkeit in Geschichte und Gegenwart. Maria Ossowski über "Von Luther zu Twitter".
Engage academia and hospitals with patient family advisors. Not rocket science, not window dressing. Basic stuff, yet a challenge. With James Harrison at UCSF. Blog subscribers: Listen to the podcast here. Scroll down through show notes to read the post. Subscribe to Health Hats, the Podcast, on your favorite podcast player Please support my podcast. CONTRIBUTE HERE Episode Notes Prefer to read, experience impaired hearing or deafness? Find FULL TRANSCRIPT at the end of the other show notes or download the printable transcript here Contents with Time-Stamped Headings to listen where you want to listen or read where you want to read (heading. time on podcast xx:xx. page # on the transcript) Proem 00:53. 1 Introducing James Harrison 02:30. 1 Eyes open to engagement in research 05:16. 2 PFAC Patient Family Advisory Council 09:43. 3 Partnering with communities 12:37. 3 Recruiting PFAC members 15:10. 4 Recovery plan 18:29. 4 Back to basics 22:15. 5 Computerizing decision support 26:28. 6 Involve stakeholders early 31:01. 7 CDS Connect 32:20. 7 The elephant in the room 36:41. 8 Reflection 39:56. 9 Please comments and ask questions at the comment section at the bottom of the show notes on LinkedIn via email DM on Instagram or Twitter to @healthhats Credits Music by permission from Joey van Leeuwen, Boston Drummer, Composer, Arranger Sponsored by Abridge Thanks to these fine people who inspired me for this episode: Libby Hoy, Lisa Stewart, Beverly Rodgers, Tracy Carney, Maureen Fagan, Crispin Goytia-Vasquez, Brendaly Rodriguez, Beverly Rogers, Norah Schwartz, Freddie White-Johnson, Neely Williams Umair Shah, Matthew Hudson, Gwen Darien, Libby Hoy Bio James Harrison's career has focused on research and quality improvement efforts that seek to improve the delivery and experiences of healthcare for people who have been hospitalized. He joined the UCSF Division of Hospital Medicine (DHM) in 2012 and is an Assistant Professor of Medicine. Before UCSF, James was based at the Surgical Outcomes Research Centre (SOuRCe) at the University of Sydney and Royal Prince Alfred Hospital in Australia. It was in Sydney that James completed his Masters of Public and PhD. James is an inaugural Scholar of the Learning Health System K12 Career Development Program funded by the Agency for Health Research & Quality (AHRQ) and the Patient Centered Outcomes Research Institute (PCORI). This Program supports scientists who conduct patient-centered outcomes research within learning health systems in order to help accelerate the translation of research and evidence into practice. His K12 focuses on research and training that supports the goal of creating age-friendly care transitions of older adults using telehealth technologies. In addition, James' growing area of research interest and expertise relates to engagement science. He has a completed a number of PCORI-funded studies seeking to explore, and describe, the methods and best practices of engaging patients and caregivers as partners and co-investigators in research and quality improvement. He has applied his research to practice and now leads two Patient & Family Advisory Councils (PFACs) – the first for a national research collaborative (www.hospitalinnovate.org) and the second for the DHM. These PFACs ensure patients and caregivers are central to research and quality improvement efforts. James is also a member of the PCORI Patient Engagement Advisory Panel and is an PCORI Ambassador. Links UCSF www.ucsf.edu UCSF Division of Hospital Medicine - https://ucsfhealthhospitalmedicine.ucsf.edu UCSF Division of Hospital Medicine PFAC https://ucsfhealthhospitalmedicine.ucsf.edu/quality-and-safety/division-hospital-medicine-patient-and-family-advisory-council Hospital Medicine Reengineering Network https://hospitalinnovate.org Hospital Medicine Reengineering Network PFAC https://hosp...
Engage academia and hospitals with patient family advisors. Not rocket science, not window dressing. Basic stuff, yet a challenge. With James Harrison at UCSF. Blog subscribers: Listen to the podcast here. Scroll down through show notes to read the post. Subscribe to Health Hats, the Podcast, on your favorite podcast player Please support my podcast. CONTRIBUTE HERE Episode Notes Prefer to read, experience impaired hearing or deafness? Find FULL TRANSCRIPT at the end of the other show notes or download the printable transcript here Contents with Time-Stamped Headings to listen where you want to listen or read where you want to read (heading. time on podcast xx:xx. page # on the transcript) Proem 00:53. 1 Introducing James Harrison 02:30. 1 Eyes open to engagement in research 05:16. 2 PFAC Patient Family Advisory Council 09:43. 3 Partnering with communities 12:37. 3 Recruiting PFAC members 15:10. 4 Recovery plan 18:29. 4 Back to basics 22:15. 5 Computerizing decision support 26:28. 6 Involve stakeholders early 31:01. 7 CDS Connect 32:20. 7 The elephant in the room 36:41. 8 Reflection 39:56. 9 Please comments and ask questions at the comment section at the bottom of the show notes on LinkedIn via email DM on Instagram or Twitter to @healthhats Credits Music by permission from Joey van Leeuwen, Boston Drummer, Composer, Arranger Sponsored by Abridge Thanks to these fine people who inspired me for this episode: Libby Hoy, Lisa Stewart, Beverly Rodgers, Tracy Carney, Maureen Fagan, Crispin Goytia-Vasquez, Brendaly Rodriguez, Beverly Rogers, Norah Schwartz, Freddie White-Johnson, Neely Williams Umair Shah, Matthew Hudson, Gwen Darien, Libby Hoy Bio James Harrison's career has focused on research and quality improvement efforts that seek to improve the delivery and experiences of healthcare for people who have been hospitalized. He joined the UCSF Division of Hospital Medicine (DHM) in 2012 and is an Assistant Professor of Medicine. Before UCSF, James was based at the Surgical Outcomes Research Centre (SOuRCe) at the University of Sydney and Royal Prince Alfred Hospital in Australia. It was in Sydney that James completed his Masters of Public and PhD. James is an inaugural Scholar of the Learning Health System K12 Career Development Program funded by the Agency for Health Research & Quality (AHRQ) and the Patient Centered Outcomes Research Institute (PCORI). This Program supports scientists who conduct patient-centered outcomes research within learning health systems in order to help accelerate the translation of research and evidence into practice. His K12 focuses on research and training that supports the goal of creating age-friendly care transitions of older adults using telehealth technologies. In addition, James' growing area of research interest and expertise relates to engagement science. He has a completed a number of PCORI-funded studies seeking to explore, and describe, the methods and best practices of engaging patients and caregivers as partners and co-investigators in research and quality improvement. He has applied his research to practice and now leads two Patient & Family Advisory Councils (PFACs) – the first for a national research collaborative (www.hospitalinnovate.org) and the second for the DHM. These PFACs ensure patients and caregivers are central to research and quality improvement efforts. James is also a member of the PCORI Patient Engagement Advisory Panel and is an PCORI Ambassador. Links UCSF www.ucsf.edu UCSF Division of Hospital Medicine - https://ucsfhealthhospitalmedicine.ucsf.edu UCSF Division of Hospital Medicine PFAC https://ucsfhealthhospitalmedicine.ucsf.edu/quality-and-safety/division-hospital-medicine-patient-and-family-advisory-council Hospital Medicine Reengineering Network https://hospitalinnovate.org Hospital Medicine Reengineering Network PFAC https://hosp...
Wat is de ‘zin’? Ik weet het niet altijd, lees erover, praat erover, maar soms ervaar ik het, kort en schijnbaar zomaar. ‘Zin’ straalt door de tonen van het derde deel uit het Vierde Brandenburgs Concert. De muziek buitelt, danst en ruist. Johann Sebastian Bach Brandenburgs Concert nr.4, BWV.1049, dl.III La Petite Bande olv Sigiswald Kuijken DHM 077308205472 4’54’’
Jack and Jeff talk the weekend, new DHM taking effect this next week, and the latest on the travel and tourism industry.
Jack and Joe talk former governors teaming up and the new DHM.
Jack and Mayor Gaylor Baird talk city budget, policing, protests, and the new DHM.
Jack and John talk new DHM and what that means for Husker volleyball and other sports with attendance, how the volleyball team is looking, the fall schedule, and LPS announcing their graduation plans.
Jack and Tim talk when the next DHM will come out and what that could look like, and the big issues on changing police structure.
Artist: Dmitry JCB (Moscow, Russia) Name: DHM Podcast #881 (Live@Gazgolder Club, Applique Na Pike Night 2020) Genre: House / Tech-House Release Date: 30.03.2020 Exclusive: Deep House Moscow Exclusive from DHM! We present for you the live recording of a two-hour dj set from Moscow DJ and producer Dmitry JCB from the best club - Gazgolder. Applique Na Pike Night. Dmitry JCB: www.facebook.com/jcbofficial Soundcloud: @jcbmusiccom Instagram: www.instagram.com/dmitryjcb CONTACT (DHM): Email — deephousemoscow@hotmail.com Follow us: www.facebook.com/deephousemsk/ www.instagram.com/deephousemoscow/ vk.com/deephousemsk
In zijn onlangs verschenen; ‘De Goldbergvariaties, een verhaal over Bach en rouw’ noemt de schrijver Philip Kennicott de muziek van Bach ‘de enige muziek die niet triviaal is, muziek die helpt de nabijheid van de dood te ondergaan en zich ermee te verzoenen’. In het eerste deel van Kennicott’s boek gaat het oa over de Chaconna uit de Tweede Partita. Johann Sebastian Bach Fantasie, BWV.944 Andrew Lawrence-King, barokharp DHM 05472775232 1’46’’ Johann Sebastian Bach Partita nr.2, BWV.1004; V. Chaconna Andrew Lawrence-King, barokharp DHM 05472775232 17’34’’
Geboren op 8 maart 1714; Bach’s tweede en meest succesvolle zoon Carl Philipp Emanuel Bach. Je kunt eindeloos struinen in zijn enorme oeuvre, maar ik koos voor dit deel uit een Fluitconcert. Zo energiek, zo hypervirtuoos, zo vol leven… (en als toegift; muziek die C Ph E Bach misschien speelde tijdens zijn concert in Groningen…) Carl Philipp Emanuel Bach Concert voor fluit, strijkers en b.c., Wq.22; III. Allegro di molto Jacques Zoon, fluit Berliner Barock Solisten DHM 88843004252 6’25’’ Carl Philipp Emanuel Bach Sonate voor toetsinstrument Wq.48 nr.3, II. Adagio Pieter Jan Belder, klavecimbel Brilliant Classics 94320 3’49’’
Nach einer längeren Winterpause und überstandenen Feiertagen melden wir uns wieder zurück. Heute mit dem zweiten Teil des DHM-Spezial: The Aftermath. Wir lassen die gesamte DHM nochmals Revue passieren und reden über Ergebnisse, Party und anderen Spaß. Aber auch der Podcast selber ist Thema, denn es wird umstrukturiert. Für alle die uns nicht reden hören wollen nochmal zusammengefasst: Podcast Folgen nur noch 2-3Wochen online auf Spotify ALLE Folgen auf Patreon oder einfach nachfragen. Ein positiver Teil des Frühstücks auf der DHM waren die Würstchen und da haben wir was ganz besonderes für euch #Werbung: Der Sponsor Maier's Fleischerei (www.mettenden-manufaktur.de), dessen Würstchen ihr auf der DHM genießen durftet, hat für alle Kornis einen Rabatt von 20% rausgehauen! Einfach beim bestellen den Code "dhm2019" eingeben und 20% sparen und das ganz ohne Mindestumsatz. Also für alle, die Bock auf echt gute Würstchen haben oder einfach nochmal etwas verschenken möchten! Vielen Dank an unsere Supporter: Ecki Maria Arne Christian Lisa Ihr wollt auch? paypal.me/kornohneflakes patreon.com/kornohneflakes
Artist: Dmitry JCB & Mikhail Kobzar (Moscow, Russia) Name: DHM Podcast #832 (Raro Music 5 Years Anniversary 2019) Genre: Tech House / Minimal Release Date: 25.12.2019 Exclusive: Deep House Moscow “Raro Music 5 Years Anniversary” is a mix-compilation from the label of bosses Dmitry JCB and Mikhail Kobzar, dedicated to the fifth anniversary of the label. 12 selected tracks and remixes from the best vinyl releases of the Raro Music label. This compilation includes works from Anrilov, Bvoice & Sickdiso ft. Lisakot and their “The World Playground” EP, Hugo Barritt, Datamode, Deep Square from VA 003, Paul Iudin and his “Motel Vera” EP, one of the latest releases of “Omega Is Back” from JCB, Mikhail Kobzar with a remix from Swoy , Kirill Golikov, Mad Dim - “Riga” EP remixed by Denis Kaznacheev. Premiere at DHM. Happy New Year 2020 and Merry Christmas! Tracklist: 01. Anrilov, Bvoice & SickDisco feat. Lisakot - The World Playground [Raro Music 002] 02. Hugo Barritt - Yin & Yang [Raro Music VA. 003] 03. Datamode - Clavus in Lingua [Raro Music VA. 003] 04. Deep Square - Subdivision State [Raro Music VA. 003] 05. Pavel Iudin – Throw [Raro Music 004] 06. Pavel Iudin - Piramida [Raro Music 004] 07. JCB, Mikhail Kobzar - Omega is Back [Raro Music 005] 08. Letkolben – Epithet (Medu Remix) [Raro Music 001] 09. JCB, Mikhail Kobzar - Omega is Back (Swoy Remix) [Raro Music 005] 10. Kirill Golikov, Mad Dim - Riga (Denis Kaznacheev Remix) [Raro Music 006] 11. JCB, Mikhail Kobzar - House of God [Raro Music 005] 12. Anrilov, Bvoice & SickDisco - Suck Da Shit [Raro Music 002] Dmitry JCB: www.facebook.com/jcbofficial Soundcloud: @jcbmusiccom Mikhail Kobzar: https://www.facebook.com/MikhailKobzar-552104071579235 Soundcloud: https://soundcloud.com/mikhail-kobzar Raro Music: https://www.facebook.com/raromusicru Soundcloud: https://soundcloud.com/raromusicru CONTACT (DHM): Email — deephousemoscow@hotmail.com Follow us: www.facebook.com/deephousemsk/ www.instagram.com/deephousemoscow/ vk.com/deephousemsk https://deephousemsk.tumblr.com/
Es ist ruhig in Studentenreiter Deutschland. Zu ruhig. Nach zwei Wochenenden ohne CHUs kommt das große Highlight des Jahres endlich in greifbare Nähe: Die Deutsche Hochschul Meisterschaft. Wir blicken zurück auf die DHMs des vergangenen Jahrzehnts, erklären warum eine DHM nicht nur dem Veranstalter einzigartige Probleme bereitet und erzählen euch vom allerfeinsten Teilnehmerfeld. Ein wichtiger Teil der DHM (und im Leben) ist das Essen und da haben wir was ganz besonderes für euch #Werbung: Der Sponsor Maier's Fleischerei (www.mettenden-manufaktur.de), dessen Würstchen ihr auf der DHM genießen dürft, hat für alle Kornis einen Rabatt von 20% rausgehauen! Einfach beim bestellen den Code "dhm2019" eingeben und 20% sparen und das ganz ohne Mindestumsatz. Also für alle, die noch keine Weihnachtsgeschenkidee haben - zugreifen! Natürlich bedanken wir uns bei unseren Supportern: Justin Yannick Norman Ines Johannes Darian Ihr wollt auch? paypal.me/kornohneflakes patreon.com/kornohneflakes
In this week's episode, I talk to Gibson Biddle, former VP of Product at Netflix and Chegg, about the DHM model--where we focus on delighting customers in hard-to-copy, margin-enhancing ways. Customer delight is always in first place. But what measures are we taking to ensure that? Let me know your thoughts at eboduch@pendo.io.
Thriving Under Uncertainty with Brooks Powell '17 and Pilar Castro-Kiltz '10 SHOW NOTES: Watch Brooks Powell pitch at Shark Tank. Find alcohol-related health from Cheers at cheershealth.com. Learn more about Princeton Arts Alumni and their "Alumni in the Arts" programming. Learn more about More Canvas Consulting: Business Management for the Arts. CREDITS: Produced by the Princeton Entrepreneurship Council. Music by Wright Seneres. Theme music by the Treadmills (Wright Seneres, electric guitar and electric bass; John Damond, Jr., drums). Engineered by Dan Kearns and Dan Quiyu at the Princeton Broadcast Center. Edited and mixed by Wright Seneres. Promotional readings by Megan Donahey '20. TRANSCRIPT: From the Princeton Entrepreneurship Council, this is the Princeton Spark. I'm Wright Seneres. The various people that make up the Princeton entrepreneurial and innovation ecosystem have long been at work, taking risks to bring transformational ideas and companies to the world, in the Nation's Service and the Service of Humanity. These are the stories of Entrepreneurship the Princeton Way. At PEC, we support Princeton-connected startups and help to build the regional entrepreneurial ecosystem in New Jersey and beyond. In our series opening three episodes, we are exploring three important aspects of entrepreneurship. If you haven't heard the first episode on taking risks, it is available now at princetonspark.com or wherever you get your podcasts, so do check that out. The very nature of entrepreneurship is doing something new and innovative, and so there is always some uncertainty involved. Navigating this uncertainty is something all entrepreneurs need to do if they want to thrive. So how do they do this? For one answer, we turned to Brooks Powell. Brooks is the founder of Cheers Health, which used to be called Thrive Plus. So in an episode on thriving, I thought I'd go to an expert. My name is Brooks Powell. I graduated from Princeton in the class of 2017. And I founded a company called Cheers, which we like to call an alcohol related health company. I came across an article that just been published in 2012. I was reading this a few months after it being published, titled "Dihydromyricetin as a novel anti-intoxication medication". And in this article, they showed that DHM, which is a chemical extract, like caffeine to coffee, or THC is marijuana, is basically the active ingredient that makes the plant work. Well, basically, in Asian countries, people will steep this leaf in hot water and drink it after consuming alcohol. And evidently, it made them feel better in the moment. And then it also made them feel better the next day. A team at UCLA, they took that, they took the chemical extract, dihydromyricetin, injected it into rats, and they found that they can instantly sober up rats. They can prevent rats from becoming alcoholics. They can cure alcoholism and rats and oh, yeah, rats given DHM show no sign of hangovers. Basically, I took this study, I found it really compelling. I brought it straight to my neuroscience professor, he thought it was compelling. He scrapped the planned class lecture and lectured on this instead. Within a month or so all of my sort of post graduation career ideas, and totally transformed to me basically thinking, you know what, I'm gonna try to start a company off of this dihydromyricetin. Starting an alcohol related health company is sure to have much uncertainty around it. I think our uncertainty is really sort of related
Thriving Under Uncertainty with Brooks Powell '17 and Pilar Castro-Kiltz '10 SHOW NOTES: Watch Brooks Powell pitch at Shark Tank. Find alcohol-related health from Cheers at cheershealth.com. Learn more about Princeton Arts Alumni and their "Alumni in the Arts" programming. Learn more about More Canvas Consulting: Business Management for the Arts. CREDITS: Produced by the Princeton Entrepreneurship Council. Music by Wright Seneres. Theme music by the Treadmills (Wright Seneres, electric guitar and electric bass; John Damond, Jr., drums). Engineered by Dan Kearns and Dan Quiyu at the Princeton Broadcast Center. Edited and mixed by Wright Seneres. Promotional readings by Megan Donahey '20. TRANSCRIPT: From the Princeton Entrepreneurship Council, this is the Princeton Spark. I’m Wright Seneres. The various people that make up the Princeton entrepreneurial and innovation ecosystem have long been at work, taking risks to bring transformational ideas and companies to the world, in the Nation’s Service and the Service of Humanity. These are the stories of Entrepreneurship the Princeton Way. At PEC, we support Princeton-connected startups and help to build the regional entrepreneurial ecosystem in New Jersey and beyond. In our series opening three episodes, we are exploring three important aspects of entrepreneurship. If you haven’t heard the first episode on taking risks, it is available now at princetonspark.com or wherever you get your podcasts, so do check that out. The very nature of entrepreneurship is doing something new and innovative, and so there is always some uncertainty involved. Navigating this uncertainty is something all entrepreneurs need to do if they want to thrive. So how do they do this? For one answer, we turned to Brooks Powell. Brooks is the founder of Cheers Health, which used to be called Thrive Plus. So in an episode on thriving, I thought I’d go to an expert. My name is Brooks Powell. I graduated from Princeton in the class of 2017. And I founded a company called Cheers, which we like to call an alcohol related health company. I came across an article that just been published in 2012. I was reading this a few months after it being published, titled "Dihydromyricetin as a novel anti-intoxication medication". And in this article, they showed that DHM, which is a chemical extract, like caffeine to coffee, or THC is marijuana, is basically the active ingredient that makes the plant work. Well, basically, in Asian countries, people will steep this leaf in hot water and drink it after consuming alcohol. And evidently, it made them feel better in the moment. And then it also made them feel better the next day. A team at UCLA, they took that, they took the chemical extract, dihydromyricetin, injected it into rats, and they found that they can instantly sober up rats. They can prevent rats from becoming alcoholics. They can cure alcoholism and rats and oh, yeah, rats given DHM show no sign of hangovers. Basically, I took this study, I found it really compelling. I brought it straight to my neuroscience professor, he thought it was compelling. He scrapped the planned class lecture and lectured on this instead. Within a month or so all of my sort of post graduation career ideas, and totally transformed to me basically thinking, you know what, I'm gonna try to start a company off of this dihydromyricetin. Starting an alcohol related health company is sure to have much uncertainty around it. I think our uncertainty is really sort of related
A busy news week gets busier: Developing: Chemical fire in Calhoun closes city schools today. At least one employee at DHM reported injured; others OK Floyd Schools are aware of 'CHS' threat on social media; says it isn't about Coosa. Normal classes Friday with extra security as a precaution. Business: IDI/Northwest Business Center plans 637,000 square feet of industrial space in Bartow. Fourth major project announced there this year. Ware Mechanical Weather Center: Record high of 99 in Rome Thursday, 100 in Cartersville. Hang on for one more day; normal temperatures return over the weekend. Plus: We're on tropics watch again Homelessness Task Force finds agreement on Rome's proposed urban camping ordinance; next meeting Sept. 26. Thursday gathering started with city officials on the defensive. Peaks & Valleys: The highs and lows of Northwest Georgia. Homeless meeting, Sept. 11 services, One Table. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/john-druckenmiller/support
A new survey from DHM Research looks at consumers in Oregon’s cannabis industry. John Horvick, vice president and director of research at DHM, shares what they learned about the age, gender, education-level, preferences, behaviors and other details of the people who are buying cannabis in Oregon.
On this episode, I talk to Paul Stringer, owner of DHM Landscaping, a commercial maintenance landscaping company in Phoenix Arizona. Paul purchased DHM almost three years ago with the idea of putting his tech and marketing experience to work in a company of his own. His focus on delighting the customer with technology and service far above what is considered normal in the industry has propelled DHM to grow upwards of 45% per year. Paul admits those rates are unsustainable indefinitely but remains committed to investing in his team and in technology to stay ahead of the competition.
In this week's episode, I talk to Gibson Biddle, former VP of Product at Netflix and Chegg, about the DHM model--where we focus on delighting customers in hard-to-copy, margin-enhancing ways. Customer delight is always in first place. But what measures are we taking to ensure that? Let me know your thoughts at eboduch@pendo.io.
Black students face significant barriers in public schools. In this episode, we talk about the Friday Forum on November 30, 2018, "How Oregon Is Failing Black Students and What We Can Do About it." We also meet Amarien Simmons from Rosemary Anderson High School to hear about his experiences in school. And we'll break down survey data about school equity with John Horvick in a new segment called "In the Margins." Dan Rivas and Justice Rajee are our hosts. DHM is our sponsor. The music was composed by Max McGrath-Riecke. You can hear more of Max's music at http://www.maxvoltagepdx.com/. To learn more about City Club or to get involved, visit us at www.pdxcityclub.org. Episode Sponsor
Oregon saw record turnout this election season. What do all these new voters tell us about the future of our state? Joining us to answer these and other questions is John Horvick, vice president and political director at DHM Research. Dan Rivas is our host. DHM is our sponsor. The music was composed by Max McGrath-Riecke. You can hear more of Max's music at http://www.maxvoltagepdx.com/. To learn more about City Club or to get involved, visit us at www.pdxcityclub.org. Episode Sponsor
Simon and Brian fulfil another lifelong dream as they sit down with legendary songwriter, producer and guitarist Nile Rodgers at Abbey Road Studios. In this detailed conversation, Nile discusses songs from his new album It's About Time, breaks down his approach to the guitar, and reveals the DHM (deep hidden meaning) behind hits for Chic, Sister Sledge, Diana Ross and David Bowie.
Su Embree is president and principal of DHM Research, a research firm dedicated to brining accurate public opinion data to lawmakers and other big decision-makers.Kerry found Su at the DHM offices in Portland, OR. They talked about the importance of using numbers to tell as story and the fallacy of the work/life balance. For more about this interview, head to http://kerrygross.com/interview-su-embree/
Sisun Lee, Founder/CEO of Morning Recovery, joins us to discuss how he manages his startup's growth in Silicon Valley. Morning Recovery: Sisun explains how he came up with the idea for Morning Recovery and executed his idea into a successful company. His Korean heritage (and Koreans' affinity for drinking) was one of the keys to getting the idea for the product. He had tried similar drinks in Korea, and wanted to dive into the science behind the drinks and how he could create his own product. DHM, an antioxidant found in Korean raisin trees, is the secret to Morning Recovery's success. After creating the drink with the help of Dr. Jing Liang, a USC professor, Sisun gave prototypes to his friends at Tesla, Uber, and Facebook. Overwhelming demand forced Sisun to quit his job at Tesla and work full-time for Morning Recovery. Indiegogo was the first major step in evaluating market demand. Sisun explains how he manages the company's explosive growth. Being first to market was a major factor in the growth. To test Morning Recovery, Sisun would give his friends placebo bottles and measure against new formulas. Version 2 will be released soon, as the Morning Recovery team underestimated how much people drink with the release of Version 1. We were lucky enough to receive a sample of Version 2! Sisun tells us what it's like managing venture capital and potential investors in Silicon Valley (there are more investors willing to invest than Morning Recovery can accept!). Their Series A round will be launched in the first quarter of 2018. Silicon Valley has played a huge impact on the success of the company. It is much easier to be successful if you're surrounded by like-minded people. Sisun only considered in Los Angeles and New York for the headquarters of Morning Recovery. The location also plays a huge role in finding talent to work for the company. Small things, such as being able to go to parties with social media celebrities, provide invaluable exposure for the company. What separates successful startups in Silicon Valley from the others? It all comes down to execution and having a clear focus. Morning Recovery is not the first hangover cure, just as Soylent is not the first meal replacement. The success can be attributed to having great products and being very marketable. What is Sisun's "normal" work schedule? It's a fire drill - get the most urgent thing done everyday. Every employee is a generalist and can be called on to perform any task. It's impossible to think even one month ahead because of the intense workload. Everything is day-to-day. What's next with Morning Recovery? Version 2 is coming to market soon and should be the main product in the future. Version 1 was a good test and measure of customer demand, but was primiarily . There also could be pills/powder sold online to provide a cheaper alternative than a bottled drink. Last call questions and answers: What's the best career advice you've received? You need to focus on the most impactful thing the company needs, identify it, and get it done. Go above and beyond your job description. What advice would your 60-year-old self give you today? Be more bold (it seems many older people regret not taking action). The best thing you have spent money on in the past 6 months: Nami Sake What media do you recommend: Thinking, Fast and Slow by Daniel Kahneman Favorite thing to drink: Nami Sake Whiskey Hennessy Cognac Special shoutouts and show notes: Indiegogo Tesla Uber Facebook Soylent - John's daily lunch Be sure to learn more about Sisun and Morning Recovery by checking out the company's website, Facebook, Twitter, and Instagram. Have any topics you want to be covered or amazing people you'd like us to interview? Let us know! You can email us at info@drunkenmoney.com. You can also find us on Facebook, Instagram, Twitter, and Linkedin. Please be sure to subscribe to our weekly mailing list at drunkenmoney.com/subscribe. About Sisun: Prior to starting Morning Recovery, Sisun was a staff product manager at Tesla, and a product manager at Uber and Facebook. He graduated with a Systems Design Engineering degree from the University of Waterloo. His story with Morning Recovery begins with his trip to Korea where he witnessed locals frequently taking drinking supplements after drinking alcohol. Back in the States, he dove into research, and created Morning Recovery with the goal of helping people get back their time. "We want you to wake up the next morning feeling amazing and ready to tackle your day." https://www.linkedin.com/in/sisunlee/
Su is the president of DHM research, leading teams in Portland, Seattle and Washington DC. She is at the head of providing information that affects taxes, voting, education reform, city planning, all the way to organization research at companies like Nike and Microsoft. But aside from all this, Su sits on several boards and is an investor in local restaurants - soon opening her own. Reach out dawn@postgradradio.com // Follow @postgradmedia and @whyweworkpod.
The Detroit Historical Museum Michigan Humane Society exhibits runs through Sunday October 9. Peter Poulos, Michigan Humane Society Community Engagement Manager gave me a tour and shared some stories about the Michigan Humane Society exhibit in the Community Gallery. Peter shares the history of the MHS, what they do and how we can each be a part of all the good things they do to protect animals, find good homes and provide some vet services. Peter talks about the recent Grand Opening of the new Michigan Humane Society facility in the New Center area in Detroit. On a fun note Shinola, a big supporter of the Michigan Humane Society created the world's longest dog leash for the "dog leash cutting" of the facility. Peter who used to work at and is a big supporter of the Detroit Historical Museum also shares what the DHM has to offer ....
новая серия миксов в моем стиле,для танцев,отдыха и поездки на машине!Эксклюзивно для паблика DHM.треклист видят друзья! Mix12 Tomas Barfod - Busy Baby (feat. Nina K) [KANT Remix] (Original Mix) Dave Nash - Slow Down (Vanilla Ace Remix) Croatia Squad - Drop That Skirt (Frey Remix) Ben Delay - Rock & Roll (Original Mix) Misha Klein feat. Ludacris - Rockstar [Free Mix] No Hopes and Yam Nor - Party Groovin! Stark D - Some Girls (No Hopes Remix) Nicolau Marinho - My Wife Take My Life (Original Mix) 2Groove, Disord3r - Ready Or Not (Original Mix) Hardsoul, Rocky Wellstack, Chappell - Criticize (Main Mix) Hardsoul Ft. Katie Costello - Shadowplay (Ben Delay Mix) Mauro Mondello & Dave Kurtis – House Kidz (Original Mix) DiscoVer. - Vogue (Original Mix) Ivan Spell - HAYDYL Volac - Drug Dealer (Rafael Carvalho Remix) Porter Robinson - Years Of War (Golden Features Remix) Hot Hotels feat. Polina Griffits - Every Single Day (Original Mix) IOWA - Одно и то же (Ivan Spell Club Mix)
новая серия миксов в моем стиле,для танцев,отдыха и поездки на машине!Эксклюзивно для паблика DHM.треклист видят друзья! Mix12 Tomas Barfod - Busy Baby (feat. Nina K) [KANT Remix] (Original Mix) Dave Nash - Slow Down (Vanilla Ace Remix) Croatia Squad - Drop That Skirt (Frey Remix) Ben Delay - Rock & Roll (Original Mix) Misha Klein feat. Ludacris - Rockstar [Free Mix] No Hopes and Yam Nor - Party Groovin! Stark D - Some Girls (No Hopes Remix) Nicolau Marinho - My Wife Take My Life (Original Mix) 2Groove, Disord3r - Ready Or Not (Original Mix) Hardsoul, Rocky Wellstack, Chappell - Criticize (Main Mix) Hardsoul Ft. Katie Costello - Shadowplay (Ben Delay Mix) Mauro Mondello & Dave Kurtis – House Kidz (Original Mix) DiscoVer. - Vogue (Original Mix) Ivan Spell - HAYDYL Volac - Drug Dealer (Rafael Carvalho Remix) Porter Robinson - Years Of War (Golden Features Remix) Hot Hotels feat. Polina Griffits - Every Single Day (Original Mix) IOWA - Одно и то же (Ivan Spell Club Mix)
In this special oversized episode of The State of Games, Dice, Darrell and TC do their darndest to sum up a whole year's worth of gaming goodness in just two hours! The trio discuss their personal picks for 2013 Game of the Year, their gaming discoveries, and favorite gaming memories from the year that was. All this, plus the Kickstarter microgame revolution, The Legend of Zelda, Brad Smoley, The Godfather, Unpub 4, the DHM 54 Card Challenge and much, much more! Happy New Year!
Explore mind and body with holistic health practitioner Nancy Sacks, DHM
Ming Hammond is Asst. Professor of Chemistry, Molecular & Cell Biology. Her research combines Chemical and Molecular Biology, Organic Chemistry; Reengineering functional RNAs, and mechanistic studies of RNA-based gene regulation. She created the web site youstem.org.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Okay. Speaker 1: Welcome to spectrum the science and technology show on k a l x Berkeley, a biweekly [00:00:30] 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Good afternoon. My name is Brad swift and I'm your host. Our interview is with assistant professor of chemistry and molecular and cell biology Ming Hammond. Her research combines the fields of chemical biology, organic chemistry, molecular biology and bioinformatics. Ming Hammond [00:01:00] received her bachelor of Science Degree from the California Institute of Technology and her phd from UC Berkeley. She created and maintains the website you stem.org this site consolidates opportunities in science, technology, engineering and math for primary and secondary school students in the Greater Bay area. Assistant Professor Ming Hammond. Welcome to spectrum. Hello. Thank you. Would you give us an overview of [00:01:30] the research that you're doing and in so doing, remind us what DNA and RNA are and how they're different. Speaker 1: Okay. Okay. I think a analogy that I like to use to describe the difference between DNA and RNA is that you can think of DNA as kind of an instruction manual for life. So that a very large instruction manual, several billion letters in length and it has all the instructions for how to make [00:02:00] all of the molecules, all the functioning parts of the cell RNA are messenger RNA is, are basically xerox copies of some pages of the DNA instruction manual that, um, gets used by the cell to translate the instructions into making proteins like enzymes and other components of the cell. Um, my lab is interested in how these RNA sequences are [00:02:30] regulated, how they're sent to different places in the cell and also how to change them so that we have, maybe we can control how the instructions are being used by the cell. Speaker 3: And so with that research, are you trying to create a generally applicable way to alter the RNA so that the gene is expressed differently? Speaker 1: Um, yes, exactly. And [00:03:00] first of all, understanding in nature how natural systems, um, control gene expression. And one reason we're interested in this is because for multicellular organisms like humans or plants, you have the same instruction manual in every single cell and yet you have multicellularity, right? So you have differences, different sets and instructions are being expressed [00:03:30] in different cell types, in different organs and in different portions of plants. For example, and were interested in understanding the basic mechanism for how the Messenger RNA is involved in ensuring that specific instructions are being followed in specific tissue types or specific cell types. Speaker 3: Does that then also include the idea that you mentioned of [00:04:00] certain of the messages are incorrect on purpose and so understanding that sounds complex, Speaker 1: right? So it's kind of interesting that one of the ways in which you can control, for example, whether a specific gene is expressed in the heart versus in the liver or the brain for example, is that messenger RNA for the same gene in the [00:04:30] brain is correct and can give rise to the proper protein and in the heart the same gene set of instructions can be spliced into messenger RNA in this specific way. That gives you a slightly different form of the protein. For example, one that has a slightly different function and therefore specific for that tissue. And then in the other case that I described, you might find in yet another tissue type that the same [00:05:00] message can be spliced so that it actually has a signal that says this is a garbage sequence, this is a nonsense message, don't follow this message. And the sal is smart enough to read these nonsense messages and know them to be nonsense. And what they do is the cell actually degrades these RNA. So for example, in that specific tissue type that the protein is never made. And so that's how you get [00:05:30] specialization of self. Speaker 3: And in your research are you trying to understand all of those cases? Speaker 1: We do most of our work in plants and we're very interested in the case where you can effectively shut off Accion in one condition, in war one cell type versus having it on or expressed in another cell type. So in plants, the mechanism that we study is [00:06:00] how these messages are lysed in these different ways. And that's called alternative splicing. And the predominant function of alternative spicing and plants appears to be this latter case where the messages either made and it's correct or it's made and has nonsense, but the reason I mentioned the other case is that it turns out something that's differentiates humans, for example, or mammals from plants. Besides the obvious differences, but a subtle [00:06:30] difference. The one I'm interested in is it turns out the majority of alternative splicing in mammals is actually to make different forms of that protein, so it's kind of interesting how the same basic mechanism is used by different organisms to do different things. Speaker 4: [inaudible]Speaker 3: you were listening to spectrum on k a l x Berkeley. Today we're talking with assistant professor Ming Hammond about [00:07:00] her work in messenger RNA and gene expression Speaker 4: [inaudible]Speaker 3: does the nonsense message have some value that you are researching that you are interested in understanding what is, what is the value of it to the, to the organism. Speaker 1: Okay. It's very important for the organism in general that the cell needs to have a way to know when a message or when a messenger RNA is [00:07:30] instructing nonsense because it's actually known that you can have mutations, for example, if you have a mutation in your gene that gives you a bad message. If sometimes that message then gets expressed as a protein, that protein with this altered function or ane may in fact lead to detrimental results, bad results for the south. Right. Um, and so, um, in general, the, there's a, [00:08:00] we call it a surveillance mechanism, so the cell is actually looking out for dad copies of the Messenger RNA. And so the cell normally has these surveillance mechanisms to, to, to play a very important role in keeping the, and keeping the cell healthy. And so I think what has happened is that the cell has started exploiting this mechanism to regulate chains for [00:08:30] tissue specificity and all of these other things I mentioned Speaker 3: in this regard. Are some cells smarter than others? Speaker 1: Hmm. I, I wouldn't say that [inaudible] Speaker 3: in terms of evolutionary activity, it would seem that this is kind of the place where that might go on in terms of changing an organism over time. How would RNA and nonsense allow for some sort of an evolutionary capacity to happen? Speaker 1: Okay. [00:09:00] First of all, the surveillance mechanism does not change the genomic DNA or she does not change the DNA instruction manual. Speaker 3: It's too far down the pipeline, right? So it's just reacting to the DNA instruction set, right? So it's really not there that any evolutionary activity is going to happen. It's going to happen at the higher lows. Right? Speaker 1: There are people that look to see for example, which, uh, which organisms do have this mechanism, right? So it's not that [00:09:30] some cells are smarter than others, but more that there are some organisms that don't have this surveillance pathway, for example. And bacteria do not, as far as we know, have NMD pathways, um, this nonsense mediated decay pathways, but a lot of organisms with a nucleus to have this mechanism. But one of the things that we're interested in in the lab is there is a lot of people that study this mechanism in humans and in other mammals. [00:10:00] And we're working in this in plants and we're looking at the comparison between them. What are the differences and what are the things that are similar Speaker 3: in your research? I noticed that there's something called molecular sensing that you're interested in. Can you explain that? Speaker 1: Sure. So, um, I mentioned that were studying how gene expression is regulated at the RNA level. And one of the really fascinating [00:10:30] things that I worked on as first as a postdoc and now that we're still working on in the lab is it turns out some of the Messenger RNA [inaudible] that exist in bacteria don't just encode the sequences for making proteins. But there is a little extra part of the Messenger RNA in the beginning part of the messenger RNA sequence that encodes what we call a ribo [00:11:00] switch. You can think about the riboswitch as basically a natural chemical sensor that's hooked up to the Messenger RNA. And what the rabis switch does is it responds to the presence of a chemical, for example, whether there is plenty of an amino acid in the south and the RNA is able to sense the presence of say the [00:11:30] amino acid and when it binds to this chemical, it changes its shape and through this confirmation or shape change, it causes the message downstream to actually get shut off. If you have enough of the amino acid, you turn off the gene that is used to make that amino acid because you don't need anymore. So I turns out there are many, many of these rabis switches [00:12:00] performing this simple chemical, boolean logic at the RNA level doing molecular sensing and in my lab were of course interested in the natural, these natural ones. And we're also interested in making unnatural ones as well. Speaker 3: And how is it that you utilize that information? Speaker 1: One way you can make use of the [inaudible] switch as I mentioned, is that its normal function is to turn on or turn off a chain depending on [00:12:30] the natural chemical logic is. So it turns out you can take the DNA sequence that encodes the ribo switch and you could put it in front of a different gene. And now that other gene also responds to this chemical. So it's actually a portable logic gate, so to speak. And what we're interested in is in making new Ribas switches, for example, making ones that can work in plants [00:13:00] because there is so far as we know, only one natural rubber switch that functions in plants and were interested in exploring whether we can transport these chemical sensors and utilize them and in other organisms including plant. Speaker 5: This is spectrum. I'm k a l x Berkeley. We're talking with the assistant professor Ming Hammond [00:13:30] about her research with messenger RNA and how it interacts with DNA genes. [inaudible] Speaker 3: so are you building those pre-IPO switches yourself or are you borrowing them from other organisms? Speaker 1: Um, well I would say it's actually a mix of both. We are also fundamentally interested in the mechanics of it too, right? How, how riboswitch with dysfunction. What is really amazing about Rabis, which is [00:14:00] is that there are so many different species of bacteria that utilize these Ribas switches and these bacteria live in all different types of climates than of them can live in extreme temperatures, both hot and cold and others are more, you know, soil dwelling organisms and live at pretty close to room temperature and all of them have the same sensor. And it's kind of an interesting question to ask how it is that the same sensor works [00:14:30] in all of these organisms? What part of the sequence of the, the switch of the RNA is responsible for for that [inaudible]. Speaker 3: So largely you, you work from the gene DNA area down into the RNA to control the expression of that gene. Speaker 1: Everything that we do does start the DNA level and we have in mind and designed for messenger RNA that we want. And then we can go back and say, okay, [00:15:00] at the DNA level, this is what the DNA instructions have to be to make that messenger RNA. And then we see, okay, let's build it weak. Then express it and see, okay, is the RNA doing? What we want it to and then further on is this messenger RNA being shut off the way that we want it to under this condition and then turned on under a different set of conditions. Speaker 3: And how do you judge whether or not you've had success? Is it pretty black and white [00:15:30] or is it somewhat gray? Speaker 1: One of the kind of very basic techniques that we use is a very simple assay. So you can imagine if we wanted to see whether under condition a this messenger RNA we designed is not making the protein versus condition B when when it is. So what we ended up using is what we call a reporter gene, a gene that expresses a protein that is fluorescent so that if [00:16:00] you shine light at a certain wavelength, you get a light emission from this protein. So we express the gene and in this case on the surface of the plant leaf and we can scan the leaf and let's say condition a is on the left hand side and condition B is on the right hand side. And we'll actually see that the right hand side, the leaf will be glowing and the left hand side of leaf not be glowing because of Ganar that we use to tact [00:16:30] the light emission from the surface of the leaf. Uh, it actually shows up as a gray scale limit. So that's how it turns out. Speaker 3: The organisms that you're currently working with, how do you select them? Speaker 1: One of the ways that you would want to select an organism is, is that other people have worked with the organism and that it's been shown by other researchers that it's easy to do the experiments that you're planning and that there are protocols developed for the experiments [00:17:00] that you're planning. And so it's kind of expedient, but we pick a plant called Nicole [inaudible], Tami Ana that is actually cousin to the tobacco plant, which is of some agricultural interests and also has been shown by other people to be very easy to work with for our experiments. Speaker 3: How has the hardware and the software that you use to do your research changed over the past? What 10 years that you've been doing this [inaudible] Speaker 1: [00:17:30] so we don't actually use much software. We can talk about the hardware. Sure we can like the development of technology to do DNA sequencing very, very rapidly has really been astonishing to see. And for my research in the RNA field, it has an equal impact I would say as well because it turns out if you want to study an RNA sequence, one of the ways we study it is that we do what's called a [00:18:00] reverse transcription. So we convert the RNA back to DNA and then we sequence the DNA that's made from the RNA. So it's kind of the reverse of the normal case of things that technology has enabled people to not just look at the human genome, but what we called a human transcriptome. So this is what are all the Messenger RNHS that are being expressed in different tissue types. And so that has led us to discovering, for [00:18:30] example, these differences in expression at different, um, messenger RNA is on a much, much grander scale. It much, much higher throughput scale than was possible 10 15 years ago. More fundamentally, it has made certain experiments that were impossible to do possible. Now the next challenge is how to sort through all that data Speaker 6: [inaudible]Speaker 5: you are tuned to k a l [00:19:00] x Berkeley. You're listening to spectrum. We're talking with Assistant Professor Mang Hammond about RNA based gene regulation Speaker 6: [inaudible].Speaker 1: Can you explain the a youth stem.org website and I believe you started this, didn't right. So my lab and I started this website called youth stem.org and the inspiration for the website is, it's actually kind of a personal story, [00:19:30] but I think it resonates with a lot of young scientists and other scientists is when I was a younger student, even before I went off to college and I was deciding what subjects I liked, what I like to do, I had these opportunities where yes, some of my science teachers saw something in me or thought that I would enjoy science and wanted to encourage me in the sciences and they would suggest that I go and do some of these programs that [00:20:00] are available in the state of Maryland, for example, where my family is from. And you know, I had a chance to work in a lab at the University of Maryland School of Pharmacy. Speaker 1: And I remember that made a really big impression on me when I was a freshman in college. And my freshman advisor asked me what I wanted to do for work study. I said that, well of course I wanted to do research in a lab because I said why I was already in a lab and in high school and I really liked it [00:20:30] and that's what I want to do for work study. And it was really exciting and really fun. So that's the origin story I guess of you stem. And in fact we have a lot of programs on the Berkeley campus for students interested in science that are, and that some of which pay actually a stipend. And not everyone can afford to pay money to do a summer program, but we have these free programs [00:21:00] that are I think really great. So I wanted to have a mechanism to point that out to local area students. Speaker 1: And the kind of idea I had was, well wouldn't it be great if we had like essentially a craigslist for bay area free local science and engineering and math programs? And so that's um, basically what we intend for a stem to be. [00:21:30] You can actually go on the website. It's you stem.org and you can click on a subject. You know, my favorite subject of course is chemistry. And so you could pick chemistry and it'll actually show you just the programs that are for students interested in chemistry. You can search by your grade and it tell you which programs are for you or you also filter by the location. So we're focused a lot on the East Bay, but there are also programs down in the South Bay down [00:22:00] in San Jose, Santa Cruz that we found in ones up in Monterrey. Speaker 3: So for people locally within the bay area who do have programs, they could contact you through the web. Speaker 1: Right? There's actually a link on the bottoms saying you're saying if you're a program director and you would like to list your program, the criteria is that we're interested in listing programs where the students can apply themselves or it can be nominated by a teacher that it's open to [00:22:30] any student that wants to apply. And uh, certainly we emphasize programs that are free or that pass state band. Speaker 3: And you recently received the NIH director's new innovator award. How did that happen? Speaker 1: Well, the short answer is I applied but um, yes. So it's, it's a really great honor to have received it and actually [00:23:00] to a members of the chemistry department received the new innovator where I this year, myself and Michelle Chang, another assistant professor in the same department. And so it, that was just really great news for both of us. And yeah, it was really a day for celebration in the lab for sure. I mean Hammon thanks very much for coming on spectrum. Thank you. It's a pleasure to be here. Thanks for having me. Brad. Speaker 6: [inaudible]Speaker 3: [00:23:30] irregular feature of spectrum is to mention a few of the science and technology events happening locally over the next few weeks. Rick Kaneski joins me for the calendar. Speaker 7: Come to nerd night [00:24:00] on Wednesday, January 18th at the rickshaw stop, one 55 [inaudible] street at Venice in San Francisco, doors at seven 30 show at eight. All ages are welcome to this $8 show at this month and our night copies of the inaugural issue of nerd night magazine will be given away. There's an article in there about cephalopod sex by the bay area's own. Rich Ross, Robyn, sue Fisher and Corey bloom will share their stories of liquid nitrogen ice cream. Their company smitten in San Francisco's first [00:24:30] made to order scoop shop and they will show off the engineering marvel that is dubbed to Kelvin that can churn up ice cream in under a minute. What do you love? Bounty and David Gallagher. We'll present Carville by the sea. San Francisco's Streetcar, suburb, and you CSF, Phd Student Tsai. Dear Etsy, we'll talk about antibody engineering and how artificially created antibodies can or will eventually fight disease. Visit s F. Dot. [inaudible] dot com for more information, Speaker 3: smoke [00:25:00] and mirrors is geoengineering a solution to global warming. Professor Alan Robock from the Department of Environmental Sciences at Rutgers University will address this question. Wednesday, January 25th 4:00 PM in Barrels Hall Room One 10 on the UC Berkeley campus. This event is free and open to the public Speaker 7: on Thursday, January 26th from seven to 9:00 PM the bone room at 1573 Solano avenue in Berkeley or present [00:25:30] eye to compound eye, the art and science of insect photography. In this free lecture insect photographer Becky Jaffe will incorporate and it dotes from biology, ecology and cultural anthropology to offer an engaging account of her field experiences that will inspire you to pick up the camera and look at insects with new eyes. Visit www.boneroompresents.com for more information now a few news items. Here's the Rick science [00:26:00] news reviews. A January 5th article in science by Sandra Garrett and Joshua Rosenthal at the University of Puerto Rico Medical Sciences campus in San Juan that shows that while octopuses in the Arctic have very similar DNA with warm water octopuses, their nerve cells are very different. This difference allows them to operate in the frigid waters and arises due to m RNA edits. These edits change the way that nerve cells opening includes gates to produce electrical impulses based on the species of octopus. This is the first [00:26:30] discovered example of m RNA editing to help an organism adapt to its environment and speculation remains as to how quickly and prevalent the mechanism might be. Speaker 3: In December, NASA announced seventh 2012 as the new target launch date for the space x commercial orbital transportation services milestone missions two and three. This mission begins with the liftoff of the Falcon nine rocket from Cape Canaveral boosting the Dragon's [00:27:00] spacecraft into low earth orbit. The space x dragon spacecraft will perform all of the commercial orbital transportation services, milestone mission two objectives, which include numerous operations in the vicinity of the International Space Station, and thereafter we'll perform the commercial orbital transportation services milestone mission three objectives. These include approach birthing with the International Space Station, astronauts opening the dragon spacecraft [00:27:30] and unloading cargo. Finally, the astronauts will close the space craft and send it back to Earth for recovery from the Pacific Ocean off the coast of California. This mission, if successful, will mark a major milestone in commercial American space flight Speaker 7: did January 4th issue of the Journal of neuroscience has an article by UCLA is Jenn Lang and others that reports promising anti-alcohol effects of a seed extract from the Asian Havana Dakis or Japanese [00:28:00] raising tree. This was first claimed to be a hangover remedy in the year six five nine rats that took dihydro, Myostatin or [inaudible] were found to take longer to become intoxicated and recovered four times more quickly than rats who did not take the extract. The extract further decrease the likelihood of hangover, anxiety and seizures in the rats. DSM also curved alcohol consumption. Rats consumed more and more alcohol gradually when it allowed, but d h m leased alcohol does not lead to this increased [00:28:30] consumption. DHM blocks alcohol's effects on Gaba receptors and the team has found no side effects in animal testing. They old next study the health effects on people Speaker 2: [inaudible]Speaker 4: the music heard during the show is from a low stone, a David album titled Folk and Acoustic released under a creative Commons attribution license 3.0 Speaker 2: [00:29:00] [inaudible] Speaker 4: production assistance from Rick Karnofsky Speaker 2: [inaudible].Speaker 4: Thank you for listening to spectrum. We are happy to hear from listeners. If you have comments about the show, please send them to us via email. [00:29:30] Our email address is spectrum dot k l x@yahoo.com join us in two weeks at the same time. [inaudible]. See acast.com/privacy for privacy and opt-out information.
Ming Hammond is Asst. Professor of Chemistry, Molecular & Cell Biology. Her research combines Chemical and Molecular Biology, Organic Chemistry; Reengineering functional RNAs, and mechanistic studies of RNA-based gene regulation. She created the web site youstem.org.TranscriptSpeaker 1: Spectrum's next. Speaker 2: Okay. Speaker 1: Welcome to spectrum the science and technology show on k a l x Berkeley, a biweekly [00:00:30] 30 minute program bringing you interviews featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 3: Good afternoon. My name is Brad swift and I'm your host. Our interview is with assistant professor of chemistry and molecular and cell biology Ming Hammond. Her research combines the fields of chemical biology, organic chemistry, molecular biology and bioinformatics. Ming Hammond [00:01:00] received her bachelor of Science Degree from the California Institute of Technology and her phd from UC Berkeley. She created and maintains the website you stem.org this site consolidates opportunities in science, technology, engineering and math for primary and secondary school students in the Greater Bay area. Assistant Professor Ming Hammond. Welcome to spectrum. Hello. Thank you. Would you give us an overview of [00:01:30] the research that you're doing and in so doing, remind us what DNA and RNA are and how they're different. Speaker 1: Okay. Okay. I think a analogy that I like to use to describe the difference between DNA and RNA is that you can think of DNA as kind of an instruction manual for life. So that a very large instruction manual, several billion letters in length and it has all the instructions for how to make [00:02:00] all of the molecules, all the functioning parts of the cell RNA are messenger RNA is, are basically xerox copies of some pages of the DNA instruction manual that, um, gets used by the cell to translate the instructions into making proteins like enzymes and other components of the cell. Um, my lab is interested in how these RNA sequences are [00:02:30] regulated, how they're sent to different places in the cell and also how to change them so that we have, maybe we can control how the instructions are being used by the cell. Speaker 3: And so with that research, are you trying to create a generally applicable way to alter the RNA so that the gene is expressed differently? Speaker 1: Um, yes, exactly. And [00:03:00] first of all, understanding in nature how natural systems, um, control gene expression. And one reason we're interested in this is because for multicellular organisms like humans or plants, you have the same instruction manual in every single cell and yet you have multicellularity, right? So you have differences, different sets and instructions are being expressed [00:03:30] in different cell types, in different organs and in different portions of plants. For example, and were interested in understanding the basic mechanism for how the Messenger RNA is involved in ensuring that specific instructions are being followed in specific tissue types or specific cell types. Speaker 3: Does that then also include the idea that you mentioned of [00:04:00] certain of the messages are incorrect on purpose and so understanding that sounds complex, Speaker 1: right? So it's kind of interesting that one of the ways in which you can control, for example, whether a specific gene is expressed in the heart versus in the liver or the brain for example, is that messenger RNA for the same gene in the [00:04:30] brain is correct and can give rise to the proper protein and in the heart the same gene set of instructions can be spliced into messenger RNA in this specific way. That gives you a slightly different form of the protein. For example, one that has a slightly different function and therefore specific for that tissue. And then in the other case that I described, you might find in yet another tissue type that the same [00:05:00] message can be spliced so that it actually has a signal that says this is a garbage sequence, this is a nonsense message, don't follow this message. And the sal is smart enough to read these nonsense messages and know them to be nonsense. And what they do is the cell actually degrades these RNA. So for example, in that specific tissue type that the protein is never made. And so that's how you get [00:05:30] specialization of self. Speaker 3: And in your research are you trying to understand all of those cases? Speaker 1: We do most of our work in plants and we're very interested in the case where you can effectively shut off Accion in one condition, in war one cell type versus having it on or expressed in another cell type. So in plants, the mechanism that we study is [00:06:00] how these messages are lysed in these different ways. And that's called alternative splicing. And the predominant function of alternative spicing and plants appears to be this latter case where the messages either made and it's correct or it's made and has nonsense, but the reason I mentioned the other case is that it turns out something that's differentiates humans, for example, or mammals from plants. Besides the obvious differences, but a subtle [00:06:30] difference. The one I'm interested in is it turns out the majority of alternative splicing in mammals is actually to make different forms of that protein, so it's kind of interesting how the same basic mechanism is used by different organisms to do different things. Speaker 4: [inaudible]Speaker 3: you were listening to spectrum on k a l x Berkeley. Today we're talking with assistant professor Ming Hammond about [00:07:00] her work in messenger RNA and gene expression Speaker 4: [inaudible]Speaker 3: does the nonsense message have some value that you are researching that you are interested in understanding what is, what is the value of it to the, to the organism. Speaker 1: Okay. It's very important for the organism in general that the cell needs to have a way to know when a message or when a messenger RNA is [00:07:30] instructing nonsense because it's actually known that you can have mutations, for example, if you have a mutation in your gene that gives you a bad message. If sometimes that message then gets expressed as a protein, that protein with this altered function or ane may in fact lead to detrimental results, bad results for the south. Right. Um, and so, um, in general, the, there's a, [00:08:00] we call it a surveillance mechanism, so the cell is actually looking out for dad copies of the Messenger RNA. And so the cell normally has these surveillance mechanisms to, to, to play a very important role in keeping the, and keeping the cell healthy. And so I think what has happened is that the cell has started exploiting this mechanism to regulate chains for [00:08:30] tissue specificity and all of these other things I mentioned Speaker 3: in this regard. Are some cells smarter than others? Speaker 1: Hmm. I, I wouldn't say that [inaudible] Speaker 3: in terms of evolutionary activity, it would seem that this is kind of the place where that might go on in terms of changing an organism over time. How would RNA and nonsense allow for some sort of an evolutionary capacity to happen? Speaker 1: Okay. [00:09:00] First of all, the surveillance mechanism does not change the genomic DNA or she does not change the DNA instruction manual. Speaker 3: It's too far down the pipeline, right? So it's just reacting to the DNA instruction set, right? So it's really not there that any evolutionary activity is going to happen. It's going to happen at the higher lows. Right? Speaker 1: There are people that look to see for example, which, uh, which organisms do have this mechanism, right? So it's not that [00:09:30] some cells are smarter than others, but more that there are some organisms that don't have this surveillance pathway, for example. And bacteria do not, as far as we know, have NMD pathways, um, this nonsense mediated decay pathways, but a lot of organisms with a nucleus to have this mechanism. But one of the things that we're interested in in the lab is there is a lot of people that study this mechanism in humans and in other mammals. [00:10:00] And we're working in this in plants and we're looking at the comparison between them. What are the differences and what are the things that are similar Speaker 3: in your research? I noticed that there's something called molecular sensing that you're interested in. Can you explain that? Speaker 1: Sure. So, um, I mentioned that were studying how gene expression is regulated at the RNA level. And one of the really fascinating [00:10:30] things that I worked on as first as a postdoc and now that we're still working on in the lab is it turns out some of the Messenger RNA [inaudible] that exist in bacteria don't just encode the sequences for making proteins. But there is a little extra part of the Messenger RNA in the beginning part of the messenger RNA sequence that encodes what we call a ribo [00:11:00] switch. You can think about the riboswitch as basically a natural chemical sensor that's hooked up to the Messenger RNA. And what the rabis switch does is it responds to the presence of a chemical, for example, whether there is plenty of an amino acid in the south and the RNA is able to sense the presence of say the [00:11:30] amino acid and when it binds to this chemical, it changes its shape and through this confirmation or shape change, it causes the message downstream to actually get shut off. If you have enough of the amino acid, you turn off the gene that is used to make that amino acid because you don't need anymore. So I turns out there are many, many of these rabis switches [00:12:00] performing this simple chemical, boolean logic at the RNA level doing molecular sensing and in my lab were of course interested in the natural, these natural ones. And we're also interested in making unnatural ones as well. Speaker 3: And how is it that you utilize that information? Speaker 1: One way you can make use of the [inaudible] switch as I mentioned, is that its normal function is to turn on or turn off a chain depending on [00:12:30] the natural chemical logic is. So it turns out you can take the DNA sequence that encodes the ribo switch and you could put it in front of a different gene. And now that other gene also responds to this chemical. So it's actually a portable logic gate, so to speak. And what we're interested in is in making new Ribas switches, for example, making ones that can work in plants [00:13:00] because there is so far as we know, only one natural rubber switch that functions in plants and were interested in exploring whether we can transport these chemical sensors and utilize them and in other organisms including plant. Speaker 5: This is spectrum. I'm k a l x Berkeley. We're talking with the assistant professor Ming Hammond [00:13:30] about her research with messenger RNA and how it interacts with DNA genes. [inaudible] Speaker 3: so are you building those pre-IPO switches yourself or are you borrowing them from other organisms? Speaker 1: Um, well I would say it's actually a mix of both. We are also fundamentally interested in the mechanics of it too, right? How, how riboswitch with dysfunction. What is really amazing about Rabis, which is [00:14:00] is that there are so many different species of bacteria that utilize these Ribas switches and these bacteria live in all different types of climates than of them can live in extreme temperatures, both hot and cold and others are more, you know, soil dwelling organisms and live at pretty close to room temperature and all of them have the same sensor. And it's kind of an interesting question to ask how it is that the same sensor works [00:14:30] in all of these organisms? What part of the sequence of the, the switch of the RNA is responsible for for that [inaudible]. Speaker 3: So largely you, you work from the gene DNA area down into the RNA to control the expression of that gene. Speaker 1: Everything that we do does start the DNA level and we have in mind and designed for messenger RNA that we want. And then we can go back and say, okay, [00:15:00] at the DNA level, this is what the DNA instructions have to be to make that messenger RNA. And then we see, okay, let's build it weak. Then express it and see, okay, is the RNA doing? What we want it to and then further on is this messenger RNA being shut off the way that we want it to under this condition and then turned on under a different set of conditions. Speaker 3: And how do you judge whether or not you've had success? Is it pretty black and white [00:15:30] or is it somewhat gray? Speaker 1: One of the kind of very basic techniques that we use is a very simple assay. So you can imagine if we wanted to see whether under condition a this messenger RNA we designed is not making the protein versus condition B when when it is. So what we ended up using is what we call a reporter gene, a gene that expresses a protein that is fluorescent so that if [00:16:00] you shine light at a certain wavelength, you get a light emission from this protein. So we express the gene and in this case on the surface of the plant leaf and we can scan the leaf and let's say condition a is on the left hand side and condition B is on the right hand side. And we'll actually see that the right hand side, the leaf will be glowing and the left hand side of leaf not be glowing because of Ganar that we use to tact [00:16:30] the light emission from the surface of the leaf. Uh, it actually shows up as a gray scale limit. So that's how it turns out. Speaker 3: The organisms that you're currently working with, how do you select them? Speaker 1: One of the ways that you would want to select an organism is, is that other people have worked with the organism and that it's been shown by other researchers that it's easy to do the experiments that you're planning and that there are protocols developed for the experiments [00:17:00] that you're planning. And so it's kind of expedient, but we pick a plant called Nicole [inaudible], Tami Ana that is actually cousin to the tobacco plant, which is of some agricultural interests and also has been shown by other people to be very easy to work with for our experiments. Speaker 3: How has the hardware and the software that you use to do your research changed over the past? What 10 years that you've been doing this [inaudible] Speaker 1: [00:17:30] so we don't actually use much software. We can talk about the hardware. Sure we can like the development of technology to do DNA sequencing very, very rapidly has really been astonishing to see. And for my research in the RNA field, it has an equal impact I would say as well because it turns out if you want to study an RNA sequence, one of the ways we study it is that we do what's called a [00:18:00] reverse transcription. So we convert the RNA back to DNA and then we sequence the DNA that's made from the RNA. So it's kind of the reverse of the normal case of things that technology has enabled people to not just look at the human genome, but what we called a human transcriptome. So this is what are all the Messenger RNHS that are being expressed in different tissue types. And so that has led us to discovering, for [00:18:30] example, these differences in expression at different, um, messenger RNA is on a much, much grander scale. It much, much higher throughput scale than was possible 10 15 years ago. More fundamentally, it has made certain experiments that were impossible to do possible. Now the next challenge is how to sort through all that data Speaker 6: [inaudible]Speaker 5: you are tuned to k a l [00:19:00] x Berkeley. You're listening to spectrum. We're talking with Assistant Professor Mang Hammond about RNA based gene regulation Speaker 6: [inaudible].Speaker 1: Can you explain the a youth stem.org website and I believe you started this, didn't right. So my lab and I started this website called youth stem.org and the inspiration for the website is, it's actually kind of a personal story, [00:19:30] but I think it resonates with a lot of young scientists and other scientists is when I was a younger student, even before I went off to college and I was deciding what subjects I liked, what I like to do, I had these opportunities where yes, some of my science teachers saw something in me or thought that I would enjoy science and wanted to encourage me in the sciences and they would suggest that I go and do some of these programs that [00:20:00] are available in the state of Maryland, for example, where my family is from. And you know, I had a chance to work in a lab at the University of Maryland School of Pharmacy. Speaker 1: And I remember that made a really big impression on me when I was a freshman in college. And my freshman advisor asked me what I wanted to do for work study. I said that, well of course I wanted to do research in a lab because I said why I was already in a lab and in high school and I really liked it [00:20:30] and that's what I want to do for work study. And it was really exciting and really fun. So that's the origin story I guess of you stem. And in fact we have a lot of programs on the Berkeley campus for students interested in science that are, and that some of which pay actually a stipend. And not everyone can afford to pay money to do a summer program, but we have these free programs [00:21:00] that are I think really great. So I wanted to have a mechanism to point that out to local area students. Speaker 1: And the kind of idea I had was, well wouldn't it be great if we had like essentially a craigslist for bay area free local science and engineering and math programs? And so that's um, basically what we intend for a stem to be. [00:21:30] You can actually go on the website. It's you stem.org and you can click on a subject. You know, my favorite subject of course is chemistry. And so you could pick chemistry and it'll actually show you just the programs that are for students interested in chemistry. You can search by your grade and it tell you which programs are for you or you also filter by the location. So we're focused a lot on the East Bay, but there are also programs down in the South Bay down [00:22:00] in San Jose, Santa Cruz that we found in ones up in Monterrey. Speaker 3: So for people locally within the bay area who do have programs, they could contact you through the web. Speaker 1: Right? There's actually a link on the bottoms saying you're saying if you're a program director and you would like to list your program, the criteria is that we're interested in listing programs where the students can apply themselves or it can be nominated by a teacher that it's open to [00:22:30] any student that wants to apply. And uh, certainly we emphasize programs that are free or that pass state band. Speaker 3: And you recently received the NIH director's new innovator award. How did that happen? Speaker 1: Well, the short answer is I applied but um, yes. So it's, it's a really great honor to have received it and actually [00:23:00] to a members of the chemistry department received the new innovator where I this year, myself and Michelle Chang, another assistant professor in the same department. And so it, that was just really great news for both of us. And yeah, it was really a day for celebration in the lab for sure. I mean Hammon thanks very much for coming on spectrum. Thank you. It's a pleasure to be here. Thanks for having me. Brad. Speaker 6: [inaudible]Speaker 3: [00:23:30] irregular feature of spectrum is to mention a few of the science and technology events happening locally over the next few weeks. Rick Kaneski joins me for the calendar. Speaker 7: Come to nerd night [00:24:00] on Wednesday, January 18th at the rickshaw stop, one 55 [inaudible] street at Venice in San Francisco, doors at seven 30 show at eight. All ages are welcome to this $8 show at this month and our night copies of the inaugural issue of nerd night magazine will be given away. There's an article in there about cephalopod sex by the bay area's own. Rich Ross, Robyn, sue Fisher and Corey bloom will share their stories of liquid nitrogen ice cream. Their company smitten in San Francisco's first [00:24:30] made to order scoop shop and they will show off the engineering marvel that is dubbed to Kelvin that can churn up ice cream in under a minute. What do you love? Bounty and David Gallagher. We'll present Carville by the sea. San Francisco's Streetcar, suburb, and you CSF, Phd Student Tsai. Dear Etsy, we'll talk about antibody engineering and how artificially created antibodies can or will eventually fight disease. Visit s F. Dot. [inaudible] dot com for more information, Speaker 3: smoke [00:25:00] and mirrors is geoengineering a solution to global warming. Professor Alan Robock from the Department of Environmental Sciences at Rutgers University will address this question. Wednesday, January 25th 4:00 PM in Barrels Hall Room One 10 on the UC Berkeley campus. This event is free and open to the public Speaker 7: on Thursday, January 26th from seven to 9:00 PM the bone room at 1573 Solano avenue in Berkeley or present [00:25:30] eye to compound eye, the art and science of insect photography. In this free lecture insect photographer Becky Jaffe will incorporate and it dotes from biology, ecology and cultural anthropology to offer an engaging account of her field experiences that will inspire you to pick up the camera and look at insects with new eyes. Visit www.boneroompresents.com for more information now a few news items. Here's the Rick science [00:26:00] news reviews. A January 5th article in science by Sandra Garrett and Joshua Rosenthal at the University of Puerto Rico Medical Sciences campus in San Juan that shows that while octopuses in the Arctic have very similar DNA with warm water octopuses, their nerve cells are very different. This difference allows them to operate in the frigid waters and arises due to m RNA edits. These edits change the way that nerve cells opening includes gates to produce electrical impulses based on the species of octopus. This is the first [00:26:30] discovered example of m RNA editing to help an organism adapt to its environment and speculation remains as to how quickly and prevalent the mechanism might be. Speaker 3: In December, NASA announced seventh 2012 as the new target launch date for the space x commercial orbital transportation services milestone missions two and three. This mission begins with the liftoff of the Falcon nine rocket from Cape Canaveral boosting the Dragon's [00:27:00] spacecraft into low earth orbit. The space x dragon spacecraft will perform all of the commercial orbital transportation services, milestone mission two objectives, which include numerous operations in the vicinity of the International Space Station, and thereafter we'll perform the commercial orbital transportation services milestone mission three objectives. These include approach birthing with the International Space Station, astronauts opening the dragon spacecraft [00:27:30] and unloading cargo. Finally, the astronauts will close the space craft and send it back to Earth for recovery from the Pacific Ocean off the coast of California. This mission, if successful, will mark a major milestone in commercial American space flight Speaker 7: did January 4th issue of the Journal of neuroscience has an article by UCLA is Jenn Lang and others that reports promising anti-alcohol effects of a seed extract from the Asian Havana Dakis or Japanese [00:28:00] raising tree. This was first claimed to be a hangover remedy in the year six five nine rats that took dihydro, Myostatin or [inaudible] were found to take longer to become intoxicated and recovered four times more quickly than rats who did not take the extract. The extract further decrease the likelihood of hangover, anxiety and seizures in the rats. DSM also curved alcohol consumption. Rats consumed more and more alcohol gradually when it allowed, but d h m leased alcohol does not lead to this increased [00:28:30] consumption. DHM blocks alcohol's effects on Gaba receptors and the team has found no side effects in animal testing. They old next study the health effects on people Speaker 2: [inaudible]Speaker 4: the music heard during the show is from a low stone, a David album titled Folk and Acoustic released under a creative Commons attribution license 3.0 Speaker 2: [00:29:00] [inaudible] Speaker 4: production assistance from Rick Karnofsky Speaker 2: [inaudible].Speaker 4: Thank you for listening to spectrum. We are happy to hear from listeners. If you have comments about the show, please send them to us via email. [00:29:30] Our email address is spectrum dot k l x@yahoo.com join us in two weeks at the same time. [inaudible]. Hosted on Acast. See acast.com/privacy for more information.
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