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Guests Dr. Andrea Necchi, Dr. Ashish Kamat and host Dr. Davide Soldato discuss JCO article "End Points for the Next-Generation Bladder-Sparing Perioperative Trials for Patients With Muscle-Invasive Bladder Cancer," focusing on the evolving treatment landscape of MIBC (muscle-invasive bladder cancer) and the need to properly design novel trials investigating non-operative management while including the incorporation of biomarkers and patient perspectives in clinical trials. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Davide Soldato: Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, medical oncologist at Ospedale San Martino in Genoa, Italy. Today we are joined by JCO authors Andrea Necchi, Associate Professor of Medical Oncology at University San Raffaele and Medical Oncology at Ospedale San Raffaele in Milan, Italy, and Ashish Kamat, Professor of Urologic Oncology and Cancer Research at University of Texas MD Anderson Cancer Center. Both Professor Necchi and Professor Kamat are internationally recognized experts in the field of genitourinary malignancy and particularly in bladder cancer. Today we will be discussing the article titled "Endpoints for the Next Generation Bladder-Sparing Perioperative Trials for Patients with Muscle-Invasive Bladder Cancer." So thank you for speaking with us, Professor Necchi and Professor Kamat. Dr. Andrea Necchi: Thank you, Davide, and thank you JCO for the opportunity. Dr. Ashish Kamat: Yeah, absolutely. It is a great honor and privilege to be discussing this very important article with you. So thank you for the invitation. Dr. Davide Soldato: The article that you just published in JCO reports the results of a consensus meeting that was held among experts in the field of genitourinary malignancy and particularly for bladder cancer. So the objective was really to define endpoints for a novel generation of trials among patients diagnosed with muscle-invasive bladder cancer. So my first question would be: what is the change in clinical practice and in clinical evidence that we have right now that prompted the start of such consensus in 2025? Dr. Andrea Necchi: So, we are living so many changes in the treatment paradigm of patients with muscle-invasive bladder cancer. In general, patients diagnosed with bladder cancer or urothelial cancer today, thanks to the advent of immunotherapy or immunotherapy combinations, and today thanks to the advent of novel antibody-drug conjugates like enfortumab vedotin in combination with immunotherapy that are actually changing the landscape of treatment of patients with metastatic disease and also are entering quite fast into the treatment paradigm of patients with organ-confined disease with a lot of clinical trials testing these combination therapies, neoadjuvantly or adjuvantly, before or after radical cystectomy. Having said that, by potentiating the efficacy of systemic therapy, an increasing number of patients that receive neoadjuvant therapy of any kind, at a certain point in time, result to have achieved a deep response to systemic therapy, evaluated radiologically with conventional imaging, CT scan or MRI, or with cystoscopy or with other urology-based techniques, urinary cytology, and so. And based on the fact that they achieve a complete response, so no residual viable disease after systemic therapy, they raise concern about the fact that they have to undergo surgery like radical cystectomy that is quite impactful for their quality of life and for the future of their lives after the surgery. So the point that the patients are raising, and the patients are raising this point, is primarily due to the efficacy of systemic therapy. And we have seen so many cases fortunately achieving a deep response. So the question about what to do with the patient that at a certain point, at the start with the commitment to radical cystectomy, but at a certain point in time change their mind towards something else if possible, depending on the fact that they have achieved a deep response, is something that is a question and is a need to which we have to provide data, information, and guidance in general to the patients. Dr. Davide Soldato: If we look at the population that the recommendations were formulated for, we are mainly speaking about patients who would be fit for cystectomy, and this is a very distinct population compared to those who are not fit for cystectomy, both from a medical oncology point of view but also from a urologic point of view in terms of surgery. So, can you explain a little bit to our listeners why you think that this distinction is critical and why you developed this recommendation especially for this population? Dr. Ashish Kamat: That is a very important distinction that you made. To build upon what Professor Necchi mentioned earlier, this question that we get from patients after neoadjuvant therapy or systemic therapy is not a new question. It has been something that they have been asking us for the last 20 or 30 years. "Do I really need to have my bladder taken out?" And patients who are especially not fit for surgery will sometimes say, "Do I need to have my bladder taken out? And if I cannot have my bladder taken out, am I going to just not have anything done?" Because the eligibility for radical cystectomy is also a moving target. Over the years with improvement in surgical technique, improvement in perioperative therapy, ERAS protocols, et cetera, it is really unusual for us to deny a patient the opportunity to have major surgery unless clearly they have very significant comorbid conditions. So I think this endeavor is more broadly encompassing of the patient population than what was evident in previous years. And I really want to give a shout out to Professor Necchi because what we did was, as part of the International Bladder Cancer Group and Professor Necchi is an integral part of the scientific advisory board, we broached this topic broadly during one of our discussions. And of course, Andrea always does this, he picks on a topic and then he says, "Okay, we need to discuss this really in detail," put together a multinational, multicenter collaborative group, but the driving force was our patients. Because our patients are constantly asking, "Do I need to lose my organ? Do I need to have radiation therapy?" which again, also, has a lot of side effects. So this was really to answer the question in today's day and age as to do we need to do local consolidation, and if so, in what way? It is not a new question, but we have newer therapies, newer technology, and better ways to answer this. So it is a much needed question that needs to be answered. And I think the distinction between non-surgical candidates and surgical candidates is a little bit blurred in today's day and age. Dr. Davide Soldato: What about the eligibility, for example, for cisplatin-based chemotherapy? Because I think that that is a very fundamental part of this type of strategy that we apply to patients with muscle-invasive bladder cancer. So we know that there are some caveats for proposing such treatment. And also this population was specifically defined inside this recommendation. Dr. Andrea Necchi: I think that the focus of our work is just to analyze what is happening after any type of systemic therapy the patient may get neoadjuvantly. So it is not actually a question of treatment eligibility or including cisplatin eligibility. This is an old question of today's practice and clinical trials. But regardless of what the patient received neoadjuvantly, the point that we have addressed in our consensus meeting was what to do next as a further step after systemic therapy or not. So basically we are- the consensus guidance includes all-comers, so patients to get any type of systemic therapy. So really non-selected based on specific features that determine a special eligibility to a special or a particular therapy. But an all-comer approach is always the winning approach for the translation to be in practice, an all-comer approach just focusing on what has happened after treatment and that we are assessing by the use of conventional imaging, MRI or CT, cystoscopy, urinary cytology, and trying to merge all together this information, all these features in a unique, shared, reliable definition of clinical complete response that could be used as a biomarker for the selection of newer therapies instead of pathological response that has been historically used, and maybe surrogate for the outcome, the long-term outcome and survival of these patients. Dr. Davide Soldato: A very specific point of the consensus was actually the definition of clinical complete response. As you were saying, this is actually a combination of several parameters including urinary cytology, the use of cross-sectional imaging, for example CT scan, but also the evaluation in cystoscopy of the bladder. Do you foresee any potential problems when applying this type of recommendation, not inside clinical trials, but in the context of routine clinical practice? Dr. Ashish Kamat: Absolutely. And that was the whole reason we had this consensus meeting. What happens nowadays in daily practice, and we see this every day at our center, we see patients referred to us. This definition or this sort of attempt to define clinical complete response is an ongoing issue. And urologists, medical oncologists, radiation oncologists are always looking to see, does my patient have a complete response? That definition and those paradigms have changed and evolved over the years. The FDA had a workshop many years ago looking at this very question. And it was to address the proposal that complete clinical response, which is a clinical definition, a clinical state, does this correlate with pathologic response? And with the technology and the systemic therapies we had then, the answer was 'no'. In fact, more patients got recurrent disease than did not get recurrent disease. And that is why, of course in the paper we mention the trials that looked at this question, the trials that evolved around this question. And I think the distinction between a clinical trial and daily practice is extremely important when we are looking at this definition per se. Because essentially what happens with this issue is that if the patient is not appropriately counseled, and if the physician does not do the appropriate clinical complete response assessment as Professor Necchi mentioned, right, cystoscopy, cytology, imaging, use of markers that are still in evolvement, we risk doing harm to the patient. So we caution in the paper too that this definition is not ready for prime time use. It is something that needs to be studied. It is a rigorous definition and currently we are recommending it for clinical trials. I am sure eventually it will trickle down into clinical practice, but that guidance was not the purpose of this consensus meeting. Dr. Davide Soldato: There are several parameters that are potentially evolving and could potentially enter inside of clinical practice. For example, you mentioned pelvic MRI and we have now very specific criteria, the VI-RADS criteria, we're able actually to diagnose and also to provide information. So along with these novel imaging techniques, we also know that there are novel biomarkers that could be explored, for example ctDNA and urinary DNA. So what I was wondering is, why were not these included inside the definition that you provide for clinical complete response? And do you think that, as we are designing these trials to potentially spare cystectomy for this patient, we should include these biomarkers very early so that we can actually provide better stratification for our patients and really propose this type of cystectomy-sparing strategy only to those where we are very confident that we have obtained a clinical complete response? Dr. Andrea Necchi: I would say you have just to wait. So a follow-up is ongoing and hard work is ongoing. At the time we met, at the time we established the meeting in mid-December last year, we had no information on the ctDNA data from major trials, with only a few exceptions. So we were just at the beginning of a story that was more than likely to change but still without numbers and without data from clinical trials. Now in just nine months or 10 months time, we have accumulated important data and newer data will be presented during just a few weeks and a few days regarding the ctDNA, circulating tumor DNA in particular, as a prognostic marker assessed baseline or assessed after neoadjuvant therapy. So the point is certainly well made and ctDNA is certainly well shaped to be incorporated in a future definition of clinical complete response. But you have to consider the fact that most of the data that we are accumulating related to ctDNA are about the post-cystectomy field or the metastatic field. So regarding neoadjuvant therapy, you know, we have neoadjuvant therapy in the context of bladder-sparing approach, basically we have no information. And the point that is emerging in our daily practice when using these biomarkers or in clinical trials, and the impression in general, is that it is a very strong biomarker associated with survival, but we absolutely do not know what is the performance of the test in the prediction of superficial bladder relapses, high-grade pTa relapse in the bladder that is left untouched in the patient. We are considering, and maybe it will be just a matter of further discussion, not just what is happening within the immediate endpoint of clinical CR, but also what is happening later with other survival endpoints. And for example, when looking at the type of events that we may see in this kind of bladder-sparing approaches, most of the events, also in the trials that have been published including the RETAIN study published in JCO, most of the events are related to superficial high-grade superficial non-muscle invasive relapses. So the ability to predict these types of events with ctDNA is completely unknown. Maybe, maybe other liquid biomarkers like urinary tumor DNA, utDNA, could be a bit better shaped in the prediction of this kind of events, you know. But we have still to build the story. So the question is good. The answer is yes, we will likely, more than likely incorporate liquid biomarkers in the definition, but we have to wait at least more data and more robust data in order to translate this information in routine practice, you know. Another consensus meeting is organized by IBCG and the same folks for November. This meeting will be primarily focused on the liquid biomarkers, the interpretation and use and approval and so of liquid biomarkers including bladder cancer. And we will likely be able to address all these, most of these open issues, so most of these points in the next meetings. Dr. Davide Soldato: In the consensus you say that probably clinical complete response is now ready to be included in early phase trials, so actually to test what is the efficacy of the regimens that is being evaluated inside of these trials. But you actually do very in-depth work of defining what are the most appropriate endpoints for later phase trials. So to be very specific, the phase three registrational trials that bring new regimens inside of this space. So I just wanted to hear a little bit about what was the definition for event-free survival, which you define as the most appropriate one for this type of trials. And as you were mentioning before, Professor Necchi, there is a very specific interest on the type of events that we observe, especially when we look at these superficial relapses inside of the bladder. So was this a very urgent matter of debate as we define which type of events should actually trigger event-free survival? And did you make a very thoughtful decision about why using this type of endpoint instead of others, for example metastasis-free survival? Dr. Ashish Kamat: Yeah, this was a matter of intense debate as you might imagine. And again, this is a moving target. So as Professor Necchi mentioned, we tend to partner with each other, our organizations, on having definitions of clinical complete response, biomarker, retreats, and then using that as a marker, and you might imagine this definition of what is appropriate event-free survival, what events matter to the patient, is something we have been talking about for two years. It was not just something that came up at the retreat. But at the retreat there was intense discussion. One of the things that we talked about was bladder-intact event-free survival because we are trying to spare the patient's bladder. And do we count bladder-intact event-free survival as something that is relevant? The patient advocates absolutely liked that, right? They wanted that. But then we also learned from some of the studies, for example from the RETAIN study, that the non-muscle invasive recurrences can actually lead to metastatic disease. It is not as benign when you have a patient with muscle-invasive bladder cancer that then develops a non-invasive tumor because maybe there is cancer growing underneath the surface that we don't detect when we look in the bladder. So a lot of those discussions were held, debated. It was a consensus. I have to say it was not 100% agreement on that particular definition, but it was broad consensus. And Andrea, do you want to clarify a little bit as to how we came about that consensus? Because I think this is a very important point we need to make. Dr. Andrea Necchi: We focused on a bit different definition of BI-EFS, Bladder-Intact Event-Free survival. Just stating EFS as an all-inclusive parameter including all type of high-grade relapse or progression or death that may happen to the patient. So that we were counting high-grade pTa, pT1, CIS relapses to the bladder and of course more deeper involvement in the muscle layer and so, and metastatic disease as a relapse. But the point is that as compared to the classical bladder-intact EFS definition of chemoradiation bladder-sparing approaches that is including muscle-invasive relapses only or death as events, we tried to be as inclusive as possible in order to be as much conservative as possible and to raise as higher the bar as possible for the success. And this is actually what the patients are asking us. So they are asking, "Okay, I can save my bladder, sparing radical cystectomy, but at which cost?" So in order to provide an answer, we have to be very, very cautious and be on the right shape, on the right position to say, "Okay, we have accomplished the most, the safest points, you know, by which you can proceed with the bladder-sparing." This is the first point. The other point is related to the MFS, metastasis-free survival that you have mentioned. For sure, it was recognized as a very important point for sure. But in the discussion was clear that our focus was in saving patients, curing the patient, and saving the bladder. Any single event, superficial event that may occur in the bladder-saving approaches of this kind may expose the patient to an extra risk of developing distant metastases, as it happened for example in the RETAIN study. So EFS defined as we have agreed and published, is actually a way of including or anticipating in a safest position the MFS. Because most or if not the entirety of the events of metastasis development in patients undergoing bladder-sparing after neoadjuvant systemic therapy were preceded by a superficial phase of disease relapse, you know. So I remember very, very few, or we can count just on the finger of one hand, the cases that have been reported in the literature developing de novo metastatic disease in the similar bladder-sparing approaches, in particular when using a maintenance immunotherapy strategy, you know, after they reach TURBT. So this is the reason why with all the limitation that Ashish has mentioned, with all the uncertainties that are still there, the nervousness that is still there, EFS, as defined in the protocol, as put in the paper, is to us at the moment is the safest way to use a primary endpoint in potentially registration trials of this kind with perioperative systemic therapy and response-adapted surgery. Dr. Ashish Kamat: And David, just to be absolutely clear for our listeners, right, so what was the event-free survival that we defined? Essentially it was a very inclusive definition. Event was defined as high-grade tumor persistence, recurrence, or progression during or after perioperative therapy, and receipt of any additional standard of care treatment including radical cystectomy, radiotherapy or even intravesical therapy. So this was done at the behest of our patient advocates because we really wanted to make a very robust definition that could be utilized appropriately as an adequate primary endpoint for both early and late phase bladder preservation trials. Dr. Davide Soldato: I think that it really highlights one of the points that I liked the most about this consensus is that it really incorporated the patient vision and a sort of shared decision making process when we are deciding how we want to design these trials that will explore this bladder-sparing surgery. And Professor Necchi mentioned something that I think will be also a very interesting question for trials that will be developed considering the activity of this combination that we are seeing right now, which is maintenance. Because right now our approach in the few cases where patients do not do any type of treatments after an induction with neoadjuvant treatments is basically represented by observation. So I was wondering if you think that the field will actually evolve to a sort of maintenance strategy even in patients that will achieve a complete clinical response? Dr. Andrea Necchi: We just mentioned briefly in the paper, this is a very important point that was touched during the discussion, and in particular was raised and discussed by FDA people participating in the meeting. And when looking at the data from the trials that were available and are still available thus far, we could provide a suggestion that maintenance immune therapy is the preferred approach in this kind of approach as it currently stands, as the data currently stand. Because the cleanest data towards the successful part of this journey is related to the studies that provided a kind of maintenance therapy, like the study with nivolumab or the RETAIN-2 study with maintenance immune therapy instead of RETAIN study that was just stopping treatment until surgery with MVAC chemotherapy. So in general the impression is that maintenance therapy may help in reducing the type of events, including the events that we incorporate in the EFS definition that we mentioned in the paper. The point that you mentioned is very important because on the other side we have a problem, a big problem of affordability and cost of the treatment. The de-escalation trials are an urgent need and represent a call for the studies. Unfortunately, as you mentioned, this is something that moves beyond the possibilities of this type of consensus because we don't have data and we have to accumulate data from clinical trials prior to saying, "Okay, certain patients could de-escalate therapy and stop therapy and some other not." So we are still at the very beginning. So we can do- we can discuss about this in the radical cystectomy paradigm but not in the bladder-sparing paradigm, you know. But this is for sure a point, a discussion point that will be taken, pretty well taken in one year or two year projection. Dr. Davide Soldato: I was wondering if in the consensus, considering that patient advocates and patient associations were also involved, did you decide to actually suggest the inclusion of patient-reported outcomes or the evaluation of shared decision-making in the development of this trial really as endpoints that should matter as much or as much as possible as event-free survival and clinical complete response? Dr. Ashish Kamat: Oh yeah, absolutely. We had patient advocates, we had the World Bladder Cancer Patient Coalition, Bladder Cancer Advocacy Network, patient representatives. And we always consider this. Shared decision-making is actually the impetus behind why these efforts have been launched, right? So it is the shared decision-making that is very, very important. It is the driving force behind what we do. And it is worth noting, for example, for the design of such studies, regulatory agencies consider response-based endpoints or overall survival as primary endpoints. But the patient advocates consider quality of life to be just as important, if not more important sometimes than overall survival numbers. Because patient advocates will say, "Well if I live longer but I'm miserable living longer, yes that works for regulatory agencies but doesn't work for us." So PROs clearly are very, very important. And, in fact, we just literally had a meeting in Houston, the IBCG meeting where PROs were a main point of what we discussed. So incorporating PROs in everything we do, not just this but everything we do, Dr. Necchi, myself, everybody involved in these fields realizes it is very, very important. So absolutely. Dr. Davide Soldato: I want to thank again Professor Necchi and Professor Kamat for joining us today. Dr. Andrea Necchi: Thank you. Dr. Ashish Kamat: It is our pleasure. Dr. Davide Soldato: Thanks again and we appreciate you sharing more on your JCO article titled "Endpoints for the Next Generation Bladder-Sparing Perioperative Trials for Patients with Muscle-Invasive Bladder Cancer." If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

In this episode of All Things Crime, host Jared Bradley sits down with Heidi Chance, a retired Phoenix Police Detective with 25 years of service, including 14 years in the Human Exploitation and Trafficking Unit.Heidi shares her powerful journey from joining the Phoenix Police Department at just 18 years old to becoming one of the nation's most respected voices on sex trafficking prevention and victim advocacy. From undercover work posing as a prostitute to investigating complex trafficking rings — and even fostering one of her rescued victims — Heidi's story is one of courage, faith, and relentless pursuit of justice.

In part 3 of this episode of All Things Crime, host Jared Bradley sits down with Heidi Chance, a retired Phoenix Police Detective with 25 years of service, including 14 years in the Human Exploitation and Trafficking Unit.Heidi shares her powerful journey from joining the Phoenix Police Department at just 18 years old to becoming one of the nation's most respected voices on sex trafficking prevention and victim advocacy. From undercover work posing as a prostitute to investigating complex trafficking rings — and even fostering one of her rescued victims — Heidi's story is one of courage, faith, and relentless pursuit of justice.

In part 2 of this episode of All Things Crime, host Jared Bradley sits down with Heidi Chance, a retired Phoenix Police Detective with 25 years of service, including 14 years in the Human Exploitation and Trafficking Unit.Heidi shares her powerful journey from joining the Phoenix Police Department at just 18 years old to becoming one of the nation's most respected voices on sex trafficking prevention and victim advocacy. From undercover work posing as a prostitute to investigating complex trafficking rings — and even fostering one of her rescued victims — Heidi's story is one of courage, faith, and relentless pursuit of justice.

In part 1 of this episode of All Things Crime, host Jared Bradley sits down with Heidi Chance, a retired Phoenix Police Detective with 25 years of service, including 14 years in the Human Exploitation and Trafficking Unit.Heidi shares her powerful journey from joining the Phoenix Police Department at just 18 years old to becoming one of the nation's most respected voices on sex trafficking prevention and victim advocacy. From undercover work posing as a prostitute to investigating complex trafficking rings — and even fostering one of her rescued victims — Heidi's story is one of courage, faith, and relentless pursuit of justice.

In this full episode of All Things Crime, host Jared dives into one of the most shocking cases out of Chicago — a repeat offender with 64 prior arrests was shot and killed while attempting to break into a woman's home. Joining him is criminal justice expert Brian Armstrong, who breaks down what this case reveals about Illinois' no-cash bail policy, repeat violent offenders, and the growing challenges faced by law enforcement.Jared and Brian also discuss the broader impact of policies like the SAFE-T Act, rising domestic violence cases, and how politics, funding, and lack of accountability are shaping crime across major U.S. cities.Whether you're a true crime fan, a law enforcement professional, or someone passionate about justice reform, this episode pulls back the curtain on the hard truths behind the headlines.Support the show:-Subscribe for more interviews and analysis-Leave a review to help others find the podcast-Share this episode with someone who cares about justice

This week I'm joined by Jared Bradley, CEO of MVAC Systems, and host of the All Things Crime Podcast. We discuss the innovative technology behind the MVAC, its applications in forensics, and its impact on solving cold cases, it's wild what this technology can do and how it's changing the game in DNA retrieval, so stick around to hear about it and some of the high profile cases it been used on.   Link M-Vac website My new thriller How It Falls Apart out now

In part 3 of this episode of All Things Crime, host Jared dives into one of the most shocking cases out of Chicago — a repeat offender with 64 prior arrests was shot and killed while attempting to break into a woman's home. Joining him is criminal justice expert Brian Armstrong, who breaks down what this case reveals about Illinois' no-cash bail policy, repeat violent offenders, and the growing challenges faced by law enforcement.Jared and Brian also discuss the broader impact of policies like the SAFE-T Act, rising domestic violence cases, and how politics, funding, and lack of accountability are shaping crime across major U.S. cities.Whether you're a true crime fan, a law enforcement professional, or someone passionate about justice reform, this episode pulls back the curtain on the hard truths behind the headlines.Support the show:-Subscribe for more interviews and analysis-Leave a review to help others find the podcast-Share this episode with someone who cares about justice

In part 2 of this episode of All Things Crime, host Jared dives into one of the most shocking cases out of Chicago — a repeat offender with 64 prior arrests was shot and killed while attempting to break into a woman's home. Joining him is criminal justice expert Brian Armstrong, who breaks down what this case reveals about Illinois' no-cash bail policy, repeat violent offenders, and the growing challenges faced by law enforcement.Jared and Brian also discuss the broader impact of policies like the SAFE-T Act, rising domestic violence cases, and how politics, funding, and lack of accountability are shaping crime across major U.S. cities.Whether you're a true crime fan, a law enforcement professional, or someone passionate about justice reform, this episode pulls back the curtain on the hard truths behind the headlines.Support the show:-Subscribe for more interviews and analysis-Leave a review to help others find the podcast-Share this episode with someone who cares about justice

In part 1 of this episode of All Things Crime, host Jared dives into one of the most shocking cases out of Chicago — a repeat offender with 64 prior arrests was shot and killed while attempting to break into a woman's home. Joining him is criminal justice expert Brian Armstrong, who breaks down what this case reveals about Illinois' no-cash bail policy, repeat violent offenders, and the growing challenges faced by law enforcement.Jared and Brian also discuss the broader impact of policies like the SAFE-T Act, rising domestic violence cases, and how politics, funding, and lack of accountability are shaping crime across major U.S. cities.Whether you're a true crime fan, a law enforcement professional, or someone passionate about justice reform, this episode pulls back the curtain on the hard truths behind the headlines.Support the show:-Subscribe for more interviews and analysis-Leave a review to help others find the podcast-Share this episode with someone who cares about justice

Welcome back to All Things Crime! In this episode, Jared sits down with Sacramento County District Attorney Thien Ho, who not only led the historic prosecution of Joseph DeAngelo—the Golden State Killer—but also authored the upcoming book The People vs. The Golden State Killer.This book is the final chapter in the Golden State Killer trilogy, following Michelle McNamara's I'll Be Gone in the Dark and Paul Holes' book on the investigation. DA Ho takes us inside the prosecution, interrogation, and capture of one of America's most infamous serial killers.We dive into:-How investigative genetic genealogy cracked the case-Never-before-revealed details of DeAngelo's arrest and interrogation-The disturbing psychology and patterns behind his crimes-Stories from the courtroom and prosecution team

Welcome back to All Things Crime! In part 2 of this episode, Jared sits down with Sacramento County District Attorney Thien Ho, who not only led the historic prosecution of Joseph DeAngelo—the Golden State Killer—but also authored the upcoming book The People vs. The Golden State Killer.This book is the final chapter in the Golden State Killer trilogy, following Michelle McNamara's I'll Be Gone in the Dark and Paul Holes' book on the investigation. DA Ho takes us inside the prosecution, interrogation, and capture of one of America's most infamous serial killers.We dive into:-How investigative genetic genealogy cracked the case-Never-before-revealed details of DeAngelo's arrest and interrogation-The disturbing psychology and patterns behind his crimes-Stories from the courtroom and prosecution team

Welcome back to All Things Crime! In part 1 of this episode, Jared sits down with Sacramento County District Attorney Thien Ho, who not only led the historic prosecution of Joseph DeAngelo—the Golden State Killer—but also authored the upcoming book The People vs. The Golden State Killer.This book is the final chapter in the Golden State Killer trilogy, following Michelle McNamara's I'll Be Gone in the Dark and Paul Holes' book on the investigation. DA Ho takes us inside the prosecution, interrogation, and capture of one of America's most infamous serial killers.We dive into:-How investigative genetic genealogy cracked the case-Never-before-revealed details of DeAngelo's arrest and interrogation-The disturbing psychology and patterns behind his crimes-Stories from the courtroom and prosecution team

Welcome back to All Things Crime! After a short break, I'm excited to return with a powerful and emotional episode. In today's episode, I'm joined by author, lawyer, and former California State Assemblyman Mike Gatto, who opens up about the tragic unsolved murder of his father in 2013.In this episode, Mike shares the heartbreaking story of losing his father in a home invasion, the frustration of living with an unsolved case, and how the tragedy led him to write his book Noir by Necessity: How My Father's Unsolved Murder Took Me to Dark Places.We discuss:-The shocking details of his father's murder-Why “safe neighborhoods” may not be as safe as they seem-The flaws and struggles within the justice system-How DNA technology and investigative tools like the M-Vac could bring hope to cold cases-What it really means for families to live with an unsolved crimeThis is not just Mike's story—it's a reminder of how every act of violence ripples through families and communities.

Welcome back to All Things Crime! After a short break, I'm excited to return with a powerful and emotional episode. In Part 3 of this episode, I'm joined by author, lawyer, and former California State Assemblyman Mike Gatto, who opens up about the tragic unsolved murder of his father in 2013.In this episode, Mike shares the heartbreaking story of losing his father in a home invasion, the frustration of living with an unsolved case, and how the tragedy led him to write his book Noir by Necessity: How My Father's Unsolved Murder Took Me to Dark Places.We discuss:-The shocking details of his father's murder-Why “safe neighborhoods” may not be as safe as they seem-The flaws and struggles within the justice system-How DNA technology and investigative tools like the M-Vac could bring hope to cold cases-What it really means for families to live with an unsolved crimeThis is not just Mike's story—it's a reminder of how every act of violence ripples through families and communities.

Could new technology help to finally reveal who killed Sophie Toscan du Plantier? After prime suspect Ian Bailey's death last year, Sophie's uncle Jean-Pierre Gazeau said their family would never get the truth. But now a Garda cold case team has used new technology, called M-Vac, to harvest DNA from items recovered at the West Cork crime scene. We talk to Jared Bradley, the man behind M-Vac, about how it has helped US investigators to crack decades-old cases. But first, Southern correspondent Barry Roche shares what we know about progress in the du Plantier case. Hosted on Acast. See acast.com/privacy for more information.

Welcome back to All Things Crime! After a short break, I'm excited to return with a powerful and emotional episode. In Part 2 of this episode, I'm joined by author, lawyer, and former California State Assemblyman Mike Gatto, who opens up about the tragic unsolved murder of his father in 2013.In this episode, Mike shares the heartbreaking story of losing his father in a home invasion, the frustration of living with an unsolved case, and how the tragedy led him to write his book Noir by Necessity: How My Father's Unsolved Murder Took Me to Dark Places.We discuss:-The shocking details of his father's murder-Why “safe neighborhoods” may not be as safe as they seem-The flaws and struggles within the justice system-How DNA technology and investigative tools like the M-Vac could bring hope to cold cases-What it really means for families to live with an unsolved crimeThis is not just Mike's story—it's a reminder of how every act of violence ripples through families and communities.

Welcome back to All Things Crime! After a short break, I'm excited to return with a powerful and emotional episode. In Part 1 of this episode, I'm joined by author, lawyer, and former California State Assemblyman Mike Gatto, who opens up about the tragic unsolved murder of his father in 2013.In this episode, Mike shares the heartbreaking story of losing his father in a home invasion, the frustration of living with an unsolved case, and how the tragedy led him to write his book Noir by Necessity: How My Father's Unsolved Murder Took Me to Dark Places.We discuss:-The shocking details of his father's murder-Why “safe neighborhoods” may not be as safe as they seem-The flaws and struggles within the justice system-How DNA technology and investigative tools like the M-Vac could bring hope to cold cases-What it really means for families to live with an unsolved crimeThis is not just Mike's story—it's a reminder of how every act of violence ripples through families and communities.

Items belonging to Sophie Toscan du Plantier, who was murdered in 1996, have been analysed with new DNA testing called M-VAC. A Garda cold case team are awaiting results. This Week speaks to Frank Buttimer, the solicitor who represented the late Ian Bailey for over twenty years.

A new court order issued on August 1 marks a major development in the infamous West Memphis Three case. Over 30 years after the tragic 1993 murders of three 8-year-old boys in West Memphis, Arkansas, the Crittenden County court has approved cutting-edge DNA testing using the M-Vac system — a forensic breakthrough that could finally reveal new answers.The M-Vac, a wet-vacuum DNA collection system, will be used on key pieces of evidence, including the shoelaces that were used to hogtie the victims, as well as possibly their clothing and other crime scene items. The order directs that this evidence be sent to Bode Technology, one of the newest labs equipped with the M-Vac system.This case, which resulted in the conviction and eventual release of Damien Echols, Jessie Misskelley Jr., and Jason Baldwin, has long been fraught with controversy, questions of police coercion, and juror misconduct. Damien Echols, originally sentenced to death, has been leading efforts to test remaining evidence using today's most advanced DNA tools.Will this be the turning point that uncovers the truth once and for all?

Jared Bradley is the president of M-Vac Systems, a cutting-edge forensic DNA collection company helping law enforcement solve cold cases once thought unsolvable. A military veteran and host of the podcast All Things Crime, Jared is a global leader in touch DNA recovery. He has worked with investigators around the world to identify suspects, exonerate the innocent, and bring long-awaited closure to victim families. Learn more: M-Vac Systems Podcast: All Things Crime In this episode of Zone 7, Crime Scene Investigator Sheryl McCollum is joined by forensic innovator Jared Bradley to explore the newly solved cold case of Kathy Halle, a 19-year-old murdered in 1979. Her case remained unsolved for 45 years—until DNA recovered using the M-Vac system identified suspected serial offender Bruce Lindahl as the killer. Sheryl and Jared unpack the investigation, the science behind M-Vac, and how support from the nonprofit Season of Justice helped bring long-overdue answers. Highlights: (0:00) Sheryl opens the episode with Kathy Halle’s story and introduces Jared Bradley (3:00) Kathy Halle disappears: a misplaced car, a rooftop purse, and early red flags (9:00) Quiet persistence: decades of case reviews, missed connections, and evolving DNA science (10:30) Cutting-edge DNA recovery leads to a 1-in-9.4-trillion match (12:45) Bruce Lindahl: a suspected serial predator whose violent end left unanswered questions (16:15) The psychology of predators: what makes serial offenders so hard to catch (18:45) M-Vac on the map: solving Krystal Beslanowitch’s murder with DNA from river rocks (23:00) “Every case. Every tool. Every time.” (25:30) Gang violence, shared clothing, and how M-Vac cut through the DNA mix (28:15) Clearing Chris Tapp: how M-Vac helped free a wrongfully convicted man (31:00) From burgers to crime scenes: M-Vac’s surprising origin story (33:15) Final reflections on persistence, partnership, and solving the unsolvable (33:30) “The M-Vac can vacuum 186 times more than a swab can.” – Jared Bradley If you’re enjoying Zone 7, please consider leaving a rating and review on Apple Podcasts—it helps others discover the show and supports our mission to share these stories. --- Sheryl “Mac” McCollum is an Emmy Award winning CSI, a writer for CrimeOnline, Forensic and Crime Scene Expert for Crime Stories with Nancy Grace, and a CSI for a metro Atlanta Police Department. She is the co-author of the textbook Cold Case: Pathways to Justice. Sheryl is also the founder and director of the Cold Case Investigative Research Institute, a collaboration between universities and colleges that brings researchers, practitioners, students and the criminal justice community together to advance techniques in solving cold cases and assist families and law enforcement with solvability factors for unsolved homicides, missing persons, and kidnapping cases. Social Links: Email: coldcase2004@gmail.com Twitter: @ColdCaseTips Facebook: @sheryl.mccollum Instagram: @officialzone7podcast See omnystudio.com/listener for privacy information.

Welcome back to All Things Crime! In this episode, Jared sits down with the incredibly insightful and entertaining Kim Davis from the Slaycation podcast for a deep dive into some truly wild true crime cases, human behavior, and the dark psychology behind it all.From the brutal Menendez Brothers case to the absolutely chilling story of Joel Guy Jr., this episode explores how trauma, entitlement, and even greed can spiral into unimaginable violence. Kim shares her perspective as a long-time true crime enthusiast with a background in social work, offering a thoughtful and often hilarious take on why some people make such horrific choices — and why society can't stop watching.Topics covered:-Why Kim might've missed her calling as a CSI-The disturbing case of Joel Guy Jr. and Thanksgiving gone wrong-What motivates people to murder those they “love”-Trauma, toxic family dynamics, and societal consequencesWhether you're a seasoned true crime junkie or just fascinated by the extremes of human behavior, this one's for you.Be sure to check out Kim's podcast Slaycation — trust us, you'll be hooked.Connect with Kim DavisFB: https://www.facebook.com/slaycationWTF/Instagram: https://www.instagram.com/slaycationwtf/Website: https://www.slaycation.wtf/Connect with Jared Bradley:LinkedIn: https://www.linkedin.com/in/jaredvbradleyWebsite: https://www.m-vac.comAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time.  The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime.  Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos.If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel https://www.youtube.com/@MVacSystemsDNACollection

Welcome back to All Things Crime! In part 3 of this episode, Jared sits down with the incredibly insightful and entertaining Kim Davis from the Slaycation podcast for a deep dive into some truly wild true crime cases, human behavior, and the dark psychology behind it all.From the brutal Menendez Brothers case to the absolutely chilling story of Joel Guy Jr., this episode explores how trauma, entitlement, and even greed can spiral into unimaginable violence. Kim shares her perspective as a long-time true crime enthusiast with a background in social work, offering a thoughtful and often hilarious take on why some people make such horrific choices — and why society can't stop watching.Topics covered:-The disturbing case of Joel Guy Jr. and Thanksgiving gone wrong-What motivates people to murder those they “love”-Trauma, toxic family dynamics, and societal consequencesWhether you're a seasoned true crime junkie or just fascinated by the extremes of human behavior, this one's for you.Be sure to check out Kim's podcast Slaycation — trust us, you'll be hooked.Connect with Kim DavisFB: https://www.facebook.com/slaycationWTF/Instagram: https://www.instagram.com/slaycationwtf/Website: https://www.slaycation.wtf/Connect with Jared Bradley:LinkedIn: https://www.linkedin.com/in/jaredvbradleyWebsite: https://www.m-vac.comAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time.  The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime.  Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos.If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel https://www.youtube.com/@MVacSystemsDNACollection

Welcome back to All Things Crime! In part 2 of this episode, Jared sits down with the incredibly insightful and entertaining Kim Davis from the Slaycation podcast for a deep dive into some truly wild true crime cases, human behavior, and the dark psychology behind it all.From the brutal Menendez Brothers case to the absolutely chilling story of Joel Guy Jr., this episode explores how trauma, entitlement, and even greed can spiral into unimaginable violence. Kim shares her perspective as a long-time true crime enthusiast with a background in social work, offering a thoughtful and often hilarious take on why some people make such horrific choices — and why society can't stop watching.Whether you're a seasoned true crime junkie or just fascinated by the extremes of human behavior, this one's for you.Be sure to check out Kim's podcast Slaycation — trust us, you'll be hooked.Connect with Kim DavisFB: https://www.facebook.com/slaycationWTF/Instagram: https://www.instagram.com/slaycationwtf/Website: https://www.slaycation.wtf/Connect with Jared Bradley:LinkedIn: https://www.linkedin.com/in/jaredvbradleyWebsite: https://www.m-vac.comAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time.  The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime.  Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos.If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel https://www.youtube.com/@MVacSystemsDNACollection

Welcome back to All Things Crime! In part 1 of this episode, Jared sits down with the incredibly insightful and entertaining Kim Davis from the Slaycation podcast for a deep dive into some truly wild true crime cases, human behavior, and the dark psychology behind it all.From the brutal Menendez Brothers case to the absolutely chilling story of Joel Guy Jr., this episode explores how trauma, entitlement, and even greed can spiral into unimaginable violence. Kim shares her perspective as a long-time true crime enthusiast with a background in social work, offering a thoughtful and often hilarious take on why some people make such horrific choices — and why society can't stop watching.Topics covered:-Why Kim might've missed her calling as a CSI-The disturbing case of Joel Guy Jr. and Thanksgiving gone wrong-What motivates people to murder those they “love”-Trauma, toxic family dynamics, and societal consequencesWhether you're a seasoned true crime junkie or just fascinated by the extremes of human behavior, this one's for you.Be sure to check out Kim's podcast Slaycation — trust us, you'll be hooked.Connect with Kim DavisFB: https://www.facebook.com/slaycationWTF/Instagram: https://www.instagram.com/slaycationwtf/Website: https://www.slaycation.wtf/Connect with Jared Bradley:LinkedIn: https://www.linkedin.com/in/jaredvbradleyWebsite: https://www.m-vac.comAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time.  The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime.  Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos.If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel https://www.youtube.com/@MVacSystemsDNACollection

The Hidden Cost of Poor Police Training.Today, I'm joined by a very special guest: Dr. Mike McCutcheon, a retired law enforcement professional with an impressive career spanning over two decades — most of it in detectives. Now a full-time professor and national law enforcement trainer, Dr. McCutcheon shares powerful insights on the critical importance of ongoing police training and the consequences when departments cut corners on it.In this thought-provoking conversation, we cover:-Dr. McCutcheon's journey from patrol officer to detective sergeant-Why training is often the first thing cut from law enforcement budgets-The real impact of bad training — and why good cops don't always make good instructors-His passion for teaching crime scene investigation, interview techniques, and body language analysis-Wild stories from the field, including how a lack of training led one trooper to let a massive fraudster walk free!Whether you're in law enforcement, a criminal justice student, or just passionate about how policing works behind the scenes, this episode will give you a deeper understanding of the system — and what it takes to fix it.

The Hidden Cost of Poor Police Training.Today, I'm joined by a very special guest: Dr. Mike McCutcheon, a retired law enforcement professional with an impressive career spanning over two decades — most of it in detectives. Now a full-time professor and national law enforcement trainer, Dr. McCutcheon shares powerful insights on the critical importance of ongoing police training and the consequences when departments cut corners on it.In this thought-provoking conversation, we cover:-Dr. McCutcheon's journey from patrol officer to detective sergeant-Why training is often the first thing cut from law enforcement budgets-The real impact of bad training — and why good cops don't always make good instructors-His passion for teaching crime scene investigation, interview techniques, and body language analysis-Wild stories from the field, including how a lack of training led one trooper to let a massive fraudster walk free!Whether you're in law enforcement, a criminal justice student, or just passionate about how policing works behind the scenes, this episode will give you a deeper understanding of the system — and what it takes to fix it.

The Hidden Cost of Poor Police Training.Today, I'm joined by a very special guest: Dr. Mike McCutcheon, a retired law enforcement professional with an impressive career spanning over two decades — most of it in detectives. Now a full-time professor and national law enforcement trainer, Dr. McCutcheon shares powerful insights on the critical importance of ongoing police training and the consequences when departments cut corners on it.In this thought-provoking conversation, we cover:-Dr. McCutcheon's journey from patrol officer to detective sergeant-Why training is often the first thing cut from law enforcement budgets-The real impact of bad training — and why good cops don't always make good instructors-His passion for teaching crime scene investigation, interview techniques, and body language analysis-Wild stories from the field, including how a lack of training led one trooper to let a massive fraudster walk free!Whether you're in law enforcement, a criminal justice student, or just passionate about how policing works behind the scenes, this episode will give you a deeper understanding of the system — and what it takes to fix it.

In this episode, we're honored to sit down with Lt. Randy Sutton — a nationally recognized law enforcement expert, decorated police officer, author, and founder of The Wounded Blue, a nonprofit organization dedicated to supporting injured and disabled officers.Randy shares jaw-dropping stories from his decades-long law enforcement career, including surviving multiple deadly encounters, his start in Princeton, and the shocking reality he faced after a career-ending stroke while on duty in Las Vegas. This inspiring interview dives deep into:-The transformation of policing over the decades-How respect for law enforcement has changed in America-The inception and mission of The Wounded Blue-The harsh treatment some officers face from their own departments after being injured-The lifelong impact of trauma and public service on copsRandy's story is a powerful reminder of the resilience, sacrifice, and courage that define our men and women in blue.

In part 2 of this episode, we're honored to sit down with Lt. Randy Sutton — a nationally recognized law enforcement expert, decorated police officer, author, and founder of The Wounded Blue, a nonprofit organization dedicated to supporting injured and disabled officers.Randy shares jaw-dropping stories from his decades-long law enforcement career, including surviving multiple deadly encounters, his start in Princeton, and the shocking reality he faced after a career-ending stroke while on duty in Las Vegas. This inspiring interview dives deep into:-The transformation of policing over the decades-How respect for law enforcement has changed in America-The inception and mission of The Wounded Blue-The harsh treatment some officers face from their own departments after being injured-The lifelong impact of trauma and public service on copsRandy's story is a powerful reminder of the resilience, sacrifice, and courage that define our men and women in blue.

In part 1 of this episode, we're honored to sit down with Lt. Randy Sutton — a nationally recognized law enforcement expert, decorated police officer, author, and founder of The Wounded Blue, a nonprofit organization dedicated to supporting injured and disabled officers.Randy shares jaw-dropping stories from his decades-long law enforcement career, including surviving multiple deadly encounters, his start in Princeton, and the shocking reality he faced after a career-ending stroke while on duty in Las Vegas. This inspiring interview dives deep into:-The transformation of policing over the decades-How respect for law enforcement has changed in America-The inception and mission of The Wounded Blue-The harsh treatment some officers face from their own departments after being injured-The lifelong impact of trauma and public service on copsRandy's story is a powerful reminder of the resilience, sacrifice, and courage that define our men and women in blue.

Cold Case Solved: The 1979 Murder of Kathy HaleIn this gripping episode of All Things Crime, Jared sits down with Detective Ryan Peat from North Aurora, Illinois, to discuss the decades-old murder of 19-year-old Kathy Halle—an innocent young woman whose life was tragically cut short in 1979.After disappearing on her way to pick up her sister from work, Kathy's case went cold for years—until a break finally came that would lead investigators to a suspect tied to multiple horrific crimes: Bruce Lindahl.Join us as we revisit the haunting details of this case, the forensic breakthroughs that reopened the investigation, and how the tireless work of detectives and new DNA technology finally brought justice to Kathy and her family.

Cold Case Solved: The 1979 Murder of Kathy HaleIn part 3 of this gripping episode of All Things Crime, Jared sits down with Detective Ryan Peat from North Aurora, Illinois, to discuss the decades-old murder of 19-year-old Kathy Halle—an innocent young woman whose life was tragically cut short in 1979.After disappearing on her way to pick up her sister from work, Kathy's case went cold for years—until a break finally came that would lead investigators to a suspect tied to multiple horrific crimes: Bruce Lindahl.Join us as we revisit the haunting details of this case, the forensic breakthroughs that reopened the investigation, and how the tireless work of detectives and new DNA technology finally brought justice to Kathy and her family.

Cold Case Solved: The 1979 Murder of Kathy HaleIn part 2 of this gripping episode of All Things Crime, Jared sits down with Detective Ryan Peat from North Aurora, Illinois, to discuss the decades-old murder of 19-year-old Kathy Halle—an innocent young woman whose life was tragically cut short in 1979.After disappearing on her way to pick up her sister from work, Kathy's case went cold for years—until a break finally came that would lead investigators to a suspect tied to multiple horrific crimes: Bruce Lindahl.Join us as we revisit the haunting details of this case, the forensic breakthroughs that reopened the investigation, and how the tireless work of detectives and new DNA technology finally brought justice to Kathy and her family.

Cold Case Solved: The 1979 Murder of Kathy HaleIn part 1of this gripping episode of All Things Crime, Jared sits down with Detective Ryan Peat from North Aurora, Illinois, to discuss the decades-old murder of 19-year-old Kathy Halle—an innocent young woman whose life was tragically cut short in 1979.After disappearing on her way to pick up her sister from work, Kathy's case went cold for years—until a break finally came that would lead investigators to a suspect tied to multiple horrific crimes: Bruce Lindahl.Join us as we revisit the haunting details of this case, the forensic breakthroughs that reopened the investigation, and how the tireless work of detectives and new DNA technology finally brought justice to Kathy and her family.

Today, I have an incredible guest—Bill Hanson, a longtime law enforcement professional and former homicide detective from Tucson, AZ. Bill has had an extensive career in homicide investigations, SWAT, and forensic advancements, and today, we're diving deep into his experiences.

Today, I have an incredible guest in part 2 of this episode—Bill Hanson, a longtime law enforcement professional and former homicide detective from Tucson, AZ. Bill has had an extensive career in homicide investigations, SWAT, and forensic advancements, and today, we're diving deep into his experiences.

Today, I have an incredible guest—Bill Hanson, a longtime law enforcement professional and former homicide detective from Tucson, AZ. Bill has had an extensive career in homicide investigations, SWAT, and forensic advancements, and today, we're diving deep into his experiences.

In this episode, we're joined by Branden Morgan, podcaster and creator of The Devil Within, a gripping show that blurs the lines between true crime and horror. Brandon shares his journey from writer to podcaster, his deep dive into the infamous satanic panic, and the chilling true story from his hometown that inspired The Devil Within.

In Part 3 of this episode, we're joined by Branden Morgan, podcaster and creator of The Devil Within, a gripping show that blurs the lines between true crime and horror. Brandon shares his journey from writer to podcaster, his deep dive into the infamous satanic panic, and the chilling true story from his hometown that inspired The Devil Within.

In Part 2 of this episode, we're joined by Branden Morgan, podcaster and creator of The Devil Within, a gripping show that blurs the lines between true crime and horror. Brandon shares his journey from writer to podcaster, his deep dive into the infamous satanic panic, and the chilling true story from his hometown that inspired The Devil Within.

In Part 1 of this episode, we're joined by Branden Morgan, podcaster and creator of The Devil Within, a gripping show that blurs the lines between true crime and horror. Brandon shares his journey from writer to podcaster, his deep dive into the infamous satanic panic, and the chilling true story from his hometown that inspired The Devil Within.

The border crisis has reached a breaking point, and if you've been following the show, you know how passionate I am about illegal immigration and the dangers it brings—including drug trafficking, human trafficking, and violent crime. We've gone all the way down to Panama's Darien Gap to see the root of the crisis firsthand.In this episode, we expose the entitlement mentality that has developed around illegal immigration and how activist policies have created a free-for-all, putting hardworking Americans at risk. We also break down the latest updates on ICE operations, the dangers our law enforcement officers face, and the shocking level of protection given to criminal illegal aliens.✅ Key Topics Discussed:-The direct impact of open border policies-How criminals exploit immigration loopholes-The alarming role of activist judges and leaked ICE operations-How law enforcement is being put in danger-The connection between entitlement culture and rising crimeThe numbers don't lie—since President Trump's executive orders, illegal border crossings have dropped by 95% in just a month. It's proof that action can be taken, despite what weak politicians claim.

Fishers PD, located just north of Indianapolis, Indiana, has seemingly perfected solving crime in record speeds.  Benefit?  By rapidly getting the bad guys off the street they remove the public threat, reduce future crimes by those individuals and more effectively utilize their investigator man hours to solve crimes that might otherwise not get the attention they deserve.By fully utilizing several cutting edge technologies, including VMD,  wet-vacuum forensic DNA collection, and rapid DNA sequencers, they are solving rapes, assaults and potential homicides in hours rather than days, weeks or even months.In essence, they start by pinpointing the DNA deposits using Vacuum Metal Deposition (VMD) and ALS to ensure they know exactly where the DNA material is located.  Then they collect the deposits using the M-Vac system to ensure they capture as much of the DNA material as possible, further concentrating the DNA on the M-Vac filter.  Then they take a portion of the filter and run it through the RapidHIT ID system, which will give them results in 90 minutes.  If those results are interpretable and from a single source, they immediately  notify the case detective with the actionable intelligence and the detectives can then be out chasing down the bad guys with hard evidence rather than waiting weeks or months for lab results.This video is but scratching the surface of how effective good police work and cutting edge technologies, utilized in a strategic and synergistic, methodical way, can remove criminals from our streets in a time-frame that would seem impossible. Links to other technologies:https://www.thermofisher.com/us/en/home/industrial/forensics/human-identification/forensic-dna-analysis/dna-analysis/rapidhit-id-system-human-identification/rapidhit-id-system-crime-labs.html) https://www.west-technology.co.uk/forensic/vacuum-metal-deposition-vmd/)https://fosterfreeman.com/dcs-5/The M-Vac System enables investigators to solve more crime through better DNA collection. It helps detectives and crime scene investigators close difficult open and cold cases.  For example, the M-Vac found probative DNA on a cold case victim's water soaked clothing, allowing the case to move forward.  The M-Vac can help you move cases forward as well. Questions regarding wet-vacuum forensic DNA collection, specific data or casework, or any MSI product or service can be answered by our team located in Sandy, Utah. As specialists in wet-vacuum and forensic DNA collection we can address your needs and show you the advantages of sampling with the M-Vac.Support the showAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time. The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime. Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos. If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel @https://www.youtube.com/c/MVacSystems...

In this episode of Oncology Unplugged, a podcast series from OncLive and MedNews Week, podcast host Chandler Park, MD, a medical oncologist at Norton Cancer Institute in Louisville, Kentucky, was joined by Petros Grivas, MD, PhD; and Ruben Raychaudhuri, MD, to talk about a pilot trial investigating neoadjuvant accelerated methotrexate, vinblastine,doxorubicin, and cisplatin (aMVAC) plus pembrolizumab (Keytruda) in patients with non-urothelial muscle-invasive bladder cancer, findings from which were presented at the 2025 Genitourinary Cancers Symposium. Dr Grivas is clinical director of the Genitourinary Cancers Program and a professor in the Clinical Research Division at Fred Hutchinson Cancer Center, as well as a professor in the Division of Hematology and Oncology at the University of Washington School of Medicine in Seattle. Dr Raychaudhuri is an assistant professor in the Clinical Research Division at Fred Hutchinson Cancer Center, as well as an assistant professor in the Division of Hematology and Oncology at the University of Washington School of Medicine. In their exclusive conversation, Drs Park, Grivas, and Raychaudhuri discussed key efficacy and safety findings from this study; the need for conducting dedicated research in bladder cancer patient populations with variant histologies; and the potential of biomarkers, such as HER2 expression, to improve the bladder cancer treatment paradigm in the future.

In this episode, we delve deep into the forces fueling chaos and examine the solutions needed to confront them. Join Jared Bradley as he welcomes Taylor Kramer, a border expert from Texas, to uncover the harsh realities unfolding at the U.S.-Mexico border. Together, they expose the organized efforts behind illegal immigration, explore the impact on local communities, and discuss the broader implications for America and beyond.Taylor shares firsthand experiences from the Darien Gap, his research into gangs, and the truth about the entitlement mentality among migrants that's causing tension at the border. The conversation also dives into the globalist push for open borders, the role of organizations like the United Nations, and the devastating effects on native cultures and local infrastructures.If you're passionate about justice and finding real-world solutions to crime and societal issues, this is an episode you don't want to miss.

In part 2 of this episode, we delve deep into the forces fueling chaos and examine the solutions needed to confront them. Join Jared Bradley as he welcomes Taylor Kramer, a border expert from Texas, to uncover the harsh realities unfolding at the U.S.-Mexico border. Together, they expose the organized efforts behind illegal immigration, explore the impact on local communities, and discuss the broader implications for America and beyond.Taylor shares firsthand experiences from the Darien Gap, his research into gangs, and the truth about the entitlement mentality among migrants that's causing tension at the border. The conversation also dives into the globalist push for open borders, the role of organizations like the United Nations, and the devastating effects on native cultures and local infrastructures.If you're passionate about justice and finding real-world solutions to crime and societal issues, this is an episode you don't want to miss.

In part 1 of this episode, we delve deep into the forces fueling chaos and examine the solutions needed to confront them. Join Jared Bradley as he welcomes Taylor Kramer, a border expert from Texas, to uncover the harsh realities unfolding at the U.S.-Mexico border. Together, they expose the organized efforts behind illegal immigration, explore the impact on local communities, and discuss the broader implications for America and beyond.Taylor shares firsthand experiences from the Darien Gap, his research into gangs, and the truth about the entitlement mentality among migrants that's causing tension at the border. The conversation also dives into the globalist push for open borders, the role of organizations like the United Nations, and the devastating effects on native cultures and local infrastructures.If you're passionate about justice and finding real-world solutions to crime and societal issues, this is an episode you don't want to miss.

Welcome to All Things Crime! We're thrilled to have you here, and we're incredibly grateful for your continued support as we approach 5,000 subscribers. This episode dives deep into the tragic and fascinating case of Uta von Schwedler, a German immigrant and genetics researcher whose death was initially ruled a suicide—until groundbreaking DNA technology unraveled the truth.Join us as we explore the meticulous and chilling crime involving Dr. John Wall, Uta's ex-husband, who orchestrated a staged suicide in a twisted attempt to cover his tracks. From forensic genealogy to the revolutionary use of the M-VAC DNA Collection System, this episode sheds light on how investigators uncovered the evidence that secured a conviction in this case.Key takeaways:- The critical role DNA technology plays in solving cold cases.- How the MVAC DNA collection system outperformed traditional methods.- Why persistence and attention to detail are vital in crime investigations.- Insights from Detective Gordon Parks on how cutting-edge tools change the game for solving complex cases.Stick around until the end for an exclusive clip of Detective Parks discussing how the M-VAC provided the breakthrough evidence in this case.Connect with Jared Bradley:LinkedIn: https://www.linkedin.com/in/jaredvbradleyWebsite: https://www.m-vac.comAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time.  The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime.  Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos.If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel https://www.youtube.com/@MVacSystemsDNACollection