Podcasts about Genoa

Valentines Day in May; Michael quits Victor; Kyle’s angel and devil and Audra; Amanda vs. Abby and Devon; Damian asks Amy to move in; and Nick thinks Sharon is acting jealous of Phyllis! Hey everybody! Why not pick up a bonus Y&R Chat episode at: http://www.GenoaCitySoap.com I love hearing from YOU! Please feel free to […]

John V Palaiologos faces rebellions from his sons and Grandsons. Forcing the Romans to become both Ottomans vassals and the pawns of Venice and Genoa.Period: 1371-91 Hosted on Acast. See acast.com/privacy for more information.

Amanda returns as Aristotle Dumas’ attorney; Sharon gets weird over Nick; Billy touches grass; Phyllis steals Billy’s phone; Adam has a plan; Amy is back; Diane has a brooch… and Audra has a super product; Kyle and Claire slow it down; and Mariah dodges Tessa’s questions! Hey everybody! Why not pick up a bonus Y&R […]

Bukan pemain atau mantan pemain bola yang jadi bintang tamunya. Kali ini Bibeche sang Mrs. Profesor akan bercerita segalanya tentang Thom Haye dan kehidupannya sebagai pasangan seorang pemain bola. Tonton episode selengkapnya!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Siúl siar ar an 15ú Bealtaine sa stair le Judy-Meg Ní Chinnéide. Plé déanta ar 1536, nuair a chiontaítear Anne Boleyn ar chúiseanna adhltranas agus tréas, ar 1829, nuair a dhiúltaíonn Dónal Ó Conaill, nua-tofa mar theachta dála, leis an mionn a thabhairt ag séanadh an Pápa agus a chreideamh Chaitliceach, agus ar bhás Dhónail Uí Chonaill i Genoa agus é 71 bliain d'aois i 1847.

Il gol del Genoa nel finale congela il tempo: gli ultimi 180 minuti di patimento, la disperata fiducia dei ragassi, il mercato che incombe e l'attesa per il Cristante belga.

Jimbo's joined by Julien Laurens, Pol Ballús, Seb Stafford-Bloor and James Horncastle for your weekly dose of Continental chatter. It's a clean sweep of four Clasico victories this season for Barcelona over Real after Sunday afternoon's bonkers 4-3 win at Montjuïc. It moves Hansi Flick's side seven points clear with three games left to play, while Carlo Ancelotti sets off into the Brazilian sunset… Over in Italy, after their midweek Champions League heroics Inter closed the gap on Napoli at the top of the table to just one point as Antonio Conte's side conceded an 84th minute equaliser from Genoa to set up a nervy finish with two games left of this enthralling Serie A campaign. We touch base with the equally dramatic title race in the Eredivisie - where Ajax's nine-point lead at the top of the table has evaporated to just one. Chasers PSV came back from 2-0 down at Feyenoord to win 3-2 in the 99th minute AND Ajax lost 3-0 at home! Michiel Jongsma stops by to tell us more. In France, Monaco locked in their UCL place courtesy of a 2-0 win over Lyon - while Marseille followed suit in their 3-1 victory at Le Havre - but could Roberto De Zerbi's future be elsewhere? And in the Bundesliga, there's wild celebrations in Hamburg as they return to the top flight for the first time in seven years - while the hunt for UCL football goes down to the last day as Dortmund look to pip Freiburg or Frankfurt to a top four finish. Plus - bicycle kicks, train journeys with footballers, Xherdan Shaqiri guiding Basel to glory and making friends with all of you… Produced by Lucy Oliva.RUNNING ORDER: • PART 1: Moments of the weekend (and adjacent things!) (00.40)• PART 2: La Liga review - Barca close in on their 28th title (11.00)• PART 3: Serie A review - Napoli open the door for Inter (22.50)• PART 4: Benfica 1-1 Sporting & Eredivisie title drama with Michiel Jongsma (39.10)• PART 5: Ligue 1 review - Monaco & Marseille secure UCL places (48.30)• PART 6: Bundesliga review - Hamburg and back - and Dortmund are too?! (55.40) Hosted on Acast. See acast.com/privacy for more information.

Welcome in for another edition of the Morning Espresso from the SDH Network, brought to you by Oglethorpe University, Atlanta's premier undergraduate learning experience and soccer powerhouse.Atlanta United came back to level their match at Soldier Field on Saturday, forcing an own goal, but then conceded a late winner to lose in Chicago. Go back and listen to the conversations I had with Ronny Deila and Ronald Hernandez after the match, the frustration is felt by everyone at the moment and they've got to find a way to turn that around quickly as they're next on the pitch in Austin on Wednesday (with gameday high temps set for 106) and back home to face Philadelphia on Saturday.Minnesota dealt Miami their 4th loss in their last 5 games, and barely had the ball in doing so. Danny Musovski in rarefied air for Seattle with goals in five straight games for the Sounders, scoring in their 3-1 win at Houston. NY Red Bulls defeated LA Galaxy 7-0 Saturday night, the worst ever loss for the Galaxy in their 30-year history.Vancouver, after their comeback 2-2 draw against LAFC last night, leads the Supporters' Shield race in MLS while Atlanta is in the bottom five in the league standings. A Classic El Clásico as Barcelona defeated Real Madrid for the fourth time this season, the first time that's been done since 1983. Madrid scored twice in the first 15 minutes through Kylian Mbappe, whose hat trick was wasted, but Barcelona had taken a 3-2 lead 20 minutes after his second goal and then added a 4th before halftime. The second half saw Mbappe complete his hat trick, a number of controversial referee decisions, and Barcelona celebrate essentially winning the league title as they only need one more point in their remaining matches.The managerial carousel is spinning in Madrid, as we expected. Fabrizio Romano reporting this morning that the deal is done for Xabi Alonso to join Real Madrid, and it will happen in time for the FIFA Club World Cup this summer. It will be a three-year contract. The semifinals are set in Mexico's Clausura as Club America will face Cruz Azul and Tigres will face Toluca. Alex Zendejas scored both goals in Las Aguilas win to set up another Mexico City derby, he has to be part of the USMNT this summer as he's had another strong season for Club America. Crazy scenes at the end of the Nottingham Forest 2-2 draw with Leicester as confusion over a late substitution and injury led to sort-of owner Evangelos Marinakis going out on the field and yelling at manager Nuno Espirito Santo. Bad look, but jumping to say that Nuno should resign over it was also over the top. Inter has cut Napoli's lead in Serie A down to one point after winning in a thunderstorm at Torino while Napoli was held to a draw by Genoa in Naples. Plenty more in the Espresso video and audio forms including my thoughts on the whistles at Trent Alexander-Arnold in Liverpool, the dangers of fan-led pitch invasions in celebration, and the risks of pregame and postgame social media trash talk from clubs. More Espresso tomorrow on the SDH Network, presented by our friends at Oglethorpe University.

L'Inter delle riserve vince col Torino, mentre il Napoli si fa beffare dal Genoa e pur restando avanti di un punto, ora non può più permettersi passi falsi. Ne parliamo con Antonio Giordano, firma della Gazzetta e con Nanu Galderisi. Chi non si aspettava un Clasico spettacolare alzi la mano. Il Barcellona non si fa abbattere dalla batosta eliminazione e, sempre col suo calcio champagne, batte 4-3 il Real avvicinandosi alla conquista della Liga. Convocato Filippo Maria Ricci. Infine, con Guido Bagatta il punto sulla conclusione della regular season della Serie A di basket.

Au programme de Tour d'Europe cette semaine, Arthur Merle vous fait passer de la France à l'Italie en passant par l'Angleterre et l'Espagne.En Ligue 1 d'abord, l'Olympique de Marseille a assuré sa qualification pour la prochaine Ligue des champions en gagnant au Havre (1-3), samedi dernier. Pour Tour d'Europe, Elton Mokolo fait le point sur la saison des Olympiens.En Serie A, l'Inter Milan est revenue dans la course au titre à la faveur de sa victoire 0-2 sur la pelouse du Torino couplé au match nul de Naples face au Genoa (2-2). Comment les Interistes vont-ils gérer le championnat et la finale de la Ligue des champions à venir ? Eléments de réponse avec Guillaume Pacini. En Premier League, l'image a fait le tour de l'Angleterre dimanche. Evangelos Marinakis, propriétaire de Nottingham Forest, est allé confronter son entraîneur, Nuno Espirito Santo, après le match nul de son équipe contre Leicester (2-2). Une attitude "totalement scandaleuse", selon Philippe Auclair, qui nous présente le personnage sulfureux.Enfin en Espagne, Anna Carreau revient sur le Clasico avec la victoire du FC Barcelone sur le Real Madrid (4-3), dimanche. Elle se penche également sur le futur des Merengues qui devraient accueillir d'ici peu Xabi Alonso comme entraîneur. Bonne écoute ! Tour d'Europe est un podcast Eurosport Football Club. Présentation : Arthur MerleGraphisme : Marko Popovic [extraits en vidéo]Réalisation : Hadrien Hiault Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Kyle and Claire’s condo blues; Diane breaks down; Victor and Phyllis are coming after Billy; Chelsea has second thoughts about Newman Media; Damien, the double agent; Tessa confronts Sharon about suspicious Mariah; and Nick tells Victoria he and Sharon eloped! Hey everybody! Why not pick up a bonus Y&R Chat episode at: http://www.GenoaCitySoap.com I love […]

A due giornate dalla fine del campionato è ancora lotta serratissima per centrare il quarto posto che vale l’accesso alla Champions League. Dopo la sconfitta del Bologna e il pareggio tra Lazio e Juve, potrà approfittarne la Roma, impegnata domani sera contro l’Atalanta. Noi ne parliamo con mister Stefano Colantuono. Spazio poi alla corsa Scudetto: Franco Vanni ci racconta le ultime da Torino, dove l’Inter tra pochi minuti scenderà in campo contro il Toro. Con Max Gallo invece facciamo il punto su ciò che succede in casa Napoli, con la squadra di Conte che attende stasera il Genoa per fare un altro passo verso il titolo. Con Guido Vaciago riavvolgiamo il nastro e ci soffermiamo sul pareggio della Juventus di ieri, pareggio che frena appunto la rincorsa al quarto posto. Vincenzo Martucci ci porta a Roma e analizza il ritorno in campo vincente di Jannik Sinner, al termine della squalifica inflitta al numero uno del mondo. Con Carlo Pernat invece voliamo in Francia per un resoconto sulla pazza gara di Motogp di Le Mans, conclusasi con la vittoria di Zarco. Infine il ciclismo, con Pier Augusto Stagi che ci illustra quanto accaduto nella terza tappa del Giro d’Italia.

Billi (@SGPSoccer) breaks down this weekend's key Serie A matches from the Matchday 36 slate, which includes Lazio v Juventus tomorrow night and Atalanta v Roma— matches with huge UCL implications.As for the title race, Napoli remain in pole position and require just two more wins. Napoli have won six of their last eight Serie A matches, including a 2-1 win over Milan, and are on a run of four consecutive home victories heading into hosting Genoa on Sunday. Exclusive SGPN Bonuses And Linkshttp://linktr.ee/sportsgamblingpodcastFollow The Sports Gambling Podcast X/Twitter - https://x.com/GamblingPodcastInstagram - https://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcastFollow The Sports Gambling Podcast HostsSean Green - http://www.twitter.com/seantgreenRyan Kramer - http://www.twitter.com/kramercentricGambling problem? Call 1-800-GAMBLER CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA)21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800 BETS-OFF (IA), 1-800-270-7117 for confidential help (MI)

Billi (@SGPSoccer) breaks down this weekend's key Serie A matches from the Matchday 36 slate, which includes Lazio v Juventus tomorrow night and Atalanta v Roma— matches with huge UCL implications. As for the title race, Napoli remain in pole position and require just two more wins. Napoli have won six of their last eight Serie A matches, including a 2-1 win over Milan, and are on a run of four consecutive home victories heading into hosting Genoa on Sunday. JOIN the SGPN community #DegensOnlyExclusive Merch, Contests and Bonus Episodes ONLY on Patreon - https://sg.pn/patreonDiscuss with fellow degens on Discord - https://sg.pn/discordDownload The Free SGPN App - https://sgpn.appCheck out the Sports Gambling Podcast on YouTube - https://sg.pn/YouTubeCheck out our website - http://sportsgamblingpodcast.com SUPPORT us by supporting our partnersUnderdog Fantasy code SGPN - Up to $1000 in BONUS CASH - https://play.underdogfantasy.com/p-sgpnRithmm - Player Props and Picks - Free 7 day trial! http://sportsgamblingpodcast.com/rithmmRebet - Social sportsbook - 100% deposit match promo code SGPN in your app store! ADVERTISE with SGPNInterested in advertising? Contact sales@sgpn.io WATCH the Sports Gambling PodcastYouTube - https://sg.pn/YouTubeTwitch - https://sg.pn/Twitch FOLLOW The Sports Gambling Podcast On Social MediaTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcast Gambling problem? Call 1-800-GAMBLER CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA)21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800 BETS-OFF (IA), 1-800-270-7117 for confidential help (MI)

The Haye Way kembali ke studio bersama Thom! Di episode ini kami akan membahas banyak berita menarik termasuk kemungkinan derby melawan Malaysia. Selain itu Thom juga akan mengumumkan sebuah berita besar! Tonton episode lengkapnya!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Serie A picks show previewing the matchday 36 games.The tighest title race in all of Europe continues! Napoli and freshly UCL final-qualified, Inter, have three final appointments before a champions is crowned! Can the Neroazurri carry on the momentum and find a way back to the first place or will Napoli dominate the last three weeks of competition? We shall see! Matchday 36 features important matchups in this fight and other trenches in the table such as the UCL qualification and relegation! Great games include: Milan vs Bologna, Lazio vs Juventus, Empoli vs Parma, Hellas Verona vs Lecce, Torino vs Inter, Napoli vs Genoa, Venezia vs Fiorentina and Atalanta vs Roma. Join our BetUSTV host, Gordon “Flash” Watson, who'll be joined by our soccer experts Mina Rzouki and Tancredi Palmeri  to discuss the best Serie A odds available, and to share with you their hottest soccer predictions, free tips, and best soccer picks for Matchday 36.Join this channel to get access to perks:   / @soccerpicksandpredictions  #SerieApicks #BetUSTV  #soccerpredictions In this video: 0:00 Serie A Matchday 36 Preview 7:51 Como vs Cagliari Match Prediction12:57 Lazio vs Juventus Match Prediction18:06 Empoli vs Parma Match Prediction23:31 Hellas Verona vs Lecce Match Prediction28:28 Napoli vs Genoa Match Prediction33:57 Torino vs Inter Match Prediction46:49 Udinese vs Monza Match Prediction50:47 Venezia vs Fiorentina Match Prediction54:17 Serie A Betting Record 54:50 Serie A Best Bets 

Host Dr. Davide Soldato and guest Dr. Harriet Kluger discuss the JCO article "Phase II Trial of Pembrolizumab in Combination With Bevacizumab for Untreated Melanoma Brain Metastases." Transcript The guest on this podcast episode has no disclosures to declare. Dr. Davide Soldato Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, Medical Oncologist at Ospedale San Martino in Genoa, Italy. Today, we are joined by JCO author Dr. Harriet Kluger. Dr. Kluger is a professor of medicine at Yale School of Medicine, Director of the Yale SPORE in Skin Cancer, and an internationally recognized expert in immuno-oncology for melanoma and renal cell carcinoma. She leads early-phase and translational trials that pair novel immunotherapies with predictive biomarkers to personalized care. Today, Dr. Kluger and I will be discussing the article titled "Phase 2 Trial of Pembrolizumab in Combination with Bevacizumab for Untreated Melanoma Brain Metastases." In this study, Dr. Kluger and colleagues evaluated four cycles of pembrolizumab plus the anti-VEGF antibody bevacizumab followed by pembrolizumab maintenance in patients with asymptomatic non-hemorrhagic melanoma brain metastases that had not previously received PD-1 therapy. Thank you for speaking with us, Dr. Kluger. Dr. Harriet Kluger Thank you for inviting me. The pleasure is really all mine. Dr. Davide Soldato So to kick off our podcast, I just wanted to ask if you could outline a little bit the biological and clinical rationale that led you to test this type of combination for patients with untreated brain metastases from metastatic melanoma. Dr. Harriet Kluger Back in approximately 2012, patients who had untreated brain metastases were excluded from all clinical trials. So by untreated, I mean brain metastases that had not received local therapy such as surgery or radiation. The reason for it was primarily because there was this fear that big molecules wouldn't penetrate brain lesions because they can't pass the blood-brain barrier. Turns out that the blood-brain barrier within a tumor is somewhat leaky and drugs sometimes can get in there. When PD-1 inhibitors were first identified as the next blockbuster class of drugs, we decided to conduct a phase 2 clinical trial of pembrolizumab monotherapy in patients with untreated brain metastases. We actually did it also in lung cancer, and we could talk about that later on. Responses were seen. The responses in the brain and the body were similar. They were concordant in melanoma patients. Now, at approximately that time, also another study was done by the Australian group by Dr. Georgina Long, where they did a randomized trial where patients who didn't require immediate steroid therapy received either nivolumab alone or nivolumab with ipilimumab, and the combination arm was substantially superior. Subsequently, also, Bristol Myers Squibb also conducted a large phase 2 multicenter trial of ipilimumab and nivolumab in patients with untreated brain metastases. And there, once again, they saw that the responses in the brain were similar to the responses in the body. Now, somewhere along the line there, we completed our anti-PD-1 monotherapy trial. And when we looked at our data, we still didn't have the data on ipilimumab and nivolumab. And our question was, “Well, how can we do better?” Just as we're always trying to do better. We saw two really big problems. One was that patients had a lot of perilesional edema. And the other one was that we were struggling with radiation necrosis in lesions that were previously Gamma Knifed. The instance of radiation necrosis was in excess of 30%. So the rationale behind this study was that if we added bevacizumab, maybe we could treat those patients who had some edema, not requiring steroids, but potentially get them on study, get that PD-1 inhibitor going, and also prevent subsequent radiation necrosis. And that was the main rationale behind the study. We had also done some preclinical work in mouse models of melanoma brain metastases and in an in vitro blood-brain barrier model where we showed that bevacizumab, or anti-VEGF, really tightens up those leaky basement membranes and therefore would be very likely to decrease the edema. Dr. Davide Soldato Thank you very much for putting in context the combination. So this was a phase 2 trial, and you included patients who had at least one lesion, and you wanted lesions that were behind 5 and 20 millimeters. Patients could be included also if the brain metastasis was higher in dimension than 20 millimeters, but it had to be treated, and it was then excluded from the evaluation of the primary objective of the trial. So regarding, a little bit, these characteristics, do you think that this is very similar to what we see in clinical practice? And what does this mean in terms of applicability of these results in clinical practice? Dr. Harriet Kluger So that's an excellent question. The brain metastasis clinical research field has somewhat been struggling with this issue of inclusion/exclusion criteria. When we started this, we showed pretty clearly that 5 to 10 millimeter lesions, which are below the RECIST criteria for inclusion, are measurable if you use MRIs with slices that are 1 to 2 millimeters. Most institutions in the United States do use these high-resolution MRIs. I don't know how applicable that is on a worldwide scale, but we certainly lowered the threshold for inclusion so that patients who have a smattering of small brain metastases would be eligible. Now, patients with single large brain metastases, the reason that we excluded those from the trial was because we were afraid that if a patient didn't respond to the systemic therapy that we were going to give them, they could really then develop severe neurological symptoms. So, for patient safety, we used 20 millimeters as the upper level for inclusion. Some of the other trials that I mentioned earlier also excluded patients with very large lesions. Now, in practice, one certainly can do Gamma Knife therapy to the large lesions and leave the smaller ones untreated. So I think it actually is very applicable to clinical practice. Dr. Davide Soldato Thank you very much for that insight, because I think that sometimes criteria for clinical trials, they have to be very restrictive. But then we know that in clinical practice, the applicability of these results is probably broader. So, going a little bit further in the results of the study, I just wanted a little bit of comment from you regarding what you saw in terms of intracranial response rate and duration of response among patients who obtained a response from the combination treatment. Dr. Harriet Kluger So we were actually surprised. When we first designed this study, as I said earlier, we weren't trying to beat out ipilimumab and nivolumab. We were really just trying to exclude those patients who wouldn't have otherwise been eligible for ipilimumab and nivolumab because of edema or possibly even previous radiation necrosis. So it was designed to differentiate between a response rate of 34%, and I believe the lower bound was somewhere in the 20s, because that's what we'd seen in the previous pembrolizumab study. What we saw in the first 20 patients that we enrolled was actually a response rate that far exceeded that. And so we enrolled another cohort to verify that result because we were concerned about premature publishing of a result that we might have achieved just by chance. The two cohorts were very similar in terms of the response rates. And certainly this still needs to be verified in a second study with additional institutions. We did include the Moffitt Cancer Center, and the response rate with Moffitt Cancer Center was very similar to the Yale Cancer Center response rate. Now, your other question was about duration of response. So the other thing that we started asking ourselves was whether this high response rate was really because the administration of the anti-VEGF will decrease the gadolinium enhancement and therefore we might actually just be seeing prettier scans but not tumor shrinkage. And the way to differentiate those two is by looking at the duration of the response. Median progression-free survival was 2.2 years. That's pretty long. The upper bound on the 95% confidence interval was not reached. I can't tell you that the duration is as good as the duration would be when you give ipilimumab. Perhaps it is less good. This was a fairly sick population of patients, and it included some who might not have been able to receive ipilimumab and nivolumab. So it provides an alternative. I do believe that we need to do a randomized trial where we compare it to ipilimumab and nivolumab, which is the current standard of care in this patient population. We do need to interpret these results with caution. I also want to point out regarding the progression-free survival that we only gave four doses of anti-VEGF. So one would think that even though anti-VEGF has a long half-life of three or four weeks, two years later, you no longer have anti-VEGF effect, presumably. So it does something when it's administered fairly early on in the course of the treatment. Dr. Davide Soldato So, in terms of clinical applicability, do you see this combination of pembrolizumab and bevacizumab - and of course, as we mentioned, this was a phase 2 trial. The number of patients included was not very high, but still you saw some very promising results when compared with the combination of ipilimumab and nivolumab. So do you see this combination as something that should be given particularly to those patients who might not be able to receive ipilimumab and nivolumab? So, for example, patients who are very symptomatic from the start or require a high dose of steroids, or also to provide a quicker response in terms of patients who have neurological symptoms, or do you think that someday it could be potentially used for all patients? Dr. Harriet Kluger The third part of your question, whether it can be used someday for all patients: I think we need to be very careful when we interpret these results. The study was substantially smaller than the ipilimumab/nivolumab trial that was conducted by Bristol Myers Squibb. Also going to point out that was a different population of patients. Those were all frontline patients. Here we had a mix of patients who'd had previous anti-CTLA-4 and frontline patients. So I don't think that we can replace ipilimumab and nivolumab with these results. But certainly the steroid-sparing aspect of it is something that we really need to take into consideration. A lot of patients have lesions in locations where edema can be dangerous, and some of them have a hard time coming off the steroids. So this is certainly a good approach for those folks. Dr. Davide Soldato And coming back to something that you mentioned in the very introduction, when you said that there were two main problems, which was one, the problem of the edema, and the second one, the problem of the radionecrosis. In your trial, there was a fair percentage of patients who received some type of local treatment before the systemic one. So the combination of pembrolizumab and bevacizumab. And most of the patients received radiosurgery. So I just wanted a brief comment regarding the incidence of radionecrosis in the trial and whether that specific component of the combination with bevacizumab was reduced. And how do you think that this fares in terms of what we see in clinical practice in terms of radionecrosis? Dr. Harriet Kluger I'm not sure that we really reduced the incidence of radiation necrosis. We saw radiation necrosis here. We saw less of it than in the trial of pembrolizumab monotherapy, but these were also different patients, different time. We saw more than we thought that we were going to see. It was 27%, I believe, which is fairly high still. We only gave the four doses of bevacizumab. Maybe to really prevent radiation necrosis, you have to continue to give the bevacizumab. That, too, needs to be tested. The reason that we gave the four doses of bevacizumab was simply because of the cost of the bevacizumab at the time. Dr. Davide Soldato Thank you very much for that comment on radionecrosis. And I really think that potentially this is a strategy, so continuing the bevacizumab, that really makes a lot of sense, especially considering that the tolerability of the regimen was really very, very good, and you didn't see any significant or serious adverse events related to bevacizumab. So just wondering if you could comment a little bit on the toxicities, whether you had anything unexpected. Dr. Harriet Kluger There was one patient who had a microperforation of a diverticulum, which was probably related to the bevacizumab. It was conservatively managed, and the patient did fine and actually remains alive now, many years later. We had one patient who had dehiscence of a previous wound. So there is some. We did not see any substantial hypertension, proteinuria, but we only gave the four doses. So it is possible that if you give it for longer, we would see some side effects. But still, relative to ipilimumab, it's very, very well tolerated. Dr. Davide Soldato Yeah, exactly. I think that the safety profile is really different when we compare the combination of ipilimumab/nivolumab with the pembrolizumab/bevacizumab. And as you said, this was a very small trial and probably we need additional results. But still, these results, in terms of tolerability and safety, I think they are very interesting. So one additional question that I think warrants a little bit of comment on your part is actually related to the presence of patients with BRAF mutation and, in general, to what you think would be the best course of treatment for these patients who present with the upfront brain metastases. So this, it's actually not completely related to the study, but I think that since patients with BRAF mutation were included, I think that this warrants a little bit of discussion on your part. Dr. Harriet Kluger So we really believe that long-term disease control, particularly in brain metastases, doesn't happen when you give BRAF/MEK inhibitors. You sometimes get long-term control if you've got oligometastatic disease in extracranial sites and if they've previously been treated with a lot of immune checkpoint inhibitors, which wasn't the case over here. So a patient who presents early in the course of the disease, regardless of their BRAF status, I do believe that between our studies and all the studies that have been done on immunotherapy earlier in the course of disease, we should withhold BRAF/MEK inhibitors unless they have overwhelming disease and we need immediate disease control, and then we switch them very quickly to immunotherapy. Can I also say something about the toxicity question from the bevacizumab? I have one more comment to make. I think it's important. We were very careful not to include patients who had overt hemorrhage from brain metastases. So melanoma brain metastases relative to other tumor types tend to bleed, and that was an exclusion criteria. We didn't see any bleeding that was attributable to the bevacizumab, but we don't know for sure that, if this is widely used, that that might not be a problem that's observed. So I would advise folks to use extreme caution and perhaps not use it outside of the setting of a clinical trial in patients with overt hemorrhage in the melanoma brain metastases. Dr. Davide Soldato Thank you very much. I think that one aspect that is really interesting in the trial is actually related to the fact that you collected a series of biomarkers, both circulating ones, but also some that were collected actually from the tissue. So just wondering if you could explain a little bit which type of biomarkers you evaluated and whether you saw any significant results that could suggest higher or lower efficacy of the combination. Dr. Harriet Kluger Thank you for that. So yes, the biomarker studies are fairly exploratory, and I want to emphasize that we don't have anything that's remotely useful in clinical practice at this juncture. But we did see an association between vessel density in the tumors and improved response to this regimen. So possibly those lesions that are more vascular are more fed by or driven by VEGF, and that could be the reason that there was improved response. We also saw that when there was less of an increase in circulating angiopoietin-2 levels, patients were more likely to respond. Whether or not that pans out in larger cohorts of patients remains to be determined. Dr. Davide Soldato Still, do you envision validation of these biomarkers in a potentially additional trial that will evaluate, again, the combination? Because I think that the signals were quite interesting, and they really make sense from a biological point of view, considering the mechanism of action of bevacizumab. So I think that, yeah, you're right, they are exploratory. But still, I think that there is very strong biological rationale. So really I wanted to congratulate you on including that specific part and on reporting it. And so the question is, really, do you envision validation of these biomarkers in larger cohorts? Dr. Harriet Kluger I would hope to see that, just as I'd like to see validation of the clinical results as well. The circulating biomarkers are very easy to do. It's a simple ELISA test. And the vessel density on the tumor is essentially CD34 staining and units per area of tumor. Also very simple to do. So I'd love to see that happen. Dr. Davide Soldato Do you think that considering the quality of the MRI that we are using right now, it would be possible to completely bypass even the evaluation on the tissue? Like, are we going in a direction where we can, at a certain point, say the amount of vessels that we see in these metastases is higher versus lower just based on MRI results? Dr. Harriet Kluger You gave me an outstanding idea for a follow-up study. I don't know whether you can measure the intensity of gadolinium as a surrogate, but certainly something worth asking our neuroradiology colleagues. Excellent idea. Thank you. Dr. Davide Soldato You're welcome. So just moving a step further, we spoke a lot about the validation of these results and the combination. And just wanted your idea on what do you think it would be more interesting to do: if designing a clinical trial that really compares pembrolizumab/bevacizumab with ipilimumab and nivolumab or going directly for the triplet. So we know that there has been some type of exploration of triplet combination in metastatic melanoma. So just your clinical impression: What would you do as an investigator? Dr. Harriet Kluger So it's under some discussion, actually. It's very difficult to compare drugs from different companies in an investigator-initiated trial. Perhaps our European colleagues can do that trial for us. In the United States, it's much harder, but it can be done through the cooperative groups, and we are actually having some discussions about that. I don't have the answer for you. It would be lovely to have a trial that compared the three drugs to ipi/nivo and to pembrolizumab/bevacizumab. So a three-arm trial. But remember, these are frontline melanoma patients. There aren't that many of them anymore like there used to be. So accrual will be hard, and we have to be practical. Dr. Davide Soldato Yeah, you're right. And in the discussion of the manuscript, you actually mentioned some other trials that are ongoing, especially one that is investigating the combination of pembro and lenvatinib, another one that is investigating the combination of nivolumab and relatlimab. So just wondering, do you think that the molecule in terms of VEGF inhibition, so bevacizumab versus lenvatinib, can really make a difference or is going to be just a mechanism of action? Of course, we don't have the results from this trial but just wondering if you could give us a general comment or your opinion on the topic. Dr. Harriet Kluger So that's a really great question. The trial of pembrolizumab and lenvatinib was our answer to the fact that bevacizumab is not manufactured by the same company as pembrolizumab, and we're trying to give a practical answer to our next study that might enable us to take this approach further. But it does turn out from our preclinical studies that bevacizumab and VEGF receptor inhibition aren't actually the same thing in terms of the effects on the blood-brain barrier or the perilesional tumor microenvironment in the brain. And these studies were done in mice and in in vitro models. Very different effects. The lenvatinib has stronger effect on the tumors themselves, the tumor cells themselves, than the bevacizumab, which has no effect whatsoever. But the lenvatinib doesn't appear to tighten up that blood-brain barrier. Dr. Davide Soldato Thank you. I think that's very interesting, and I think it's going to be interesting to see also results of these trials to actually improve and give more options to our patients in terms of different mechanism of action, different side effects. Because in the end, one thing that we discussed is that some combination may be useful in some specific clinical situation while others cannot be applicable, like, for example, an all immunotherapy-based combination. Just one final comment, because I think that we focused a lot on the intracranial response and progression-free survival. You briefly mentioned this but just wanted to reinforce the concept. Did you see any differences in terms of intracranial versus extracranial response for those patients who also had extracranial disease with the combination of pembro and bevacizumab? Dr. Harriet Kluger So the responses were almost always concordant. There were a couple of cases that might have had a body response and not an intracranial response and vice-versa, but the vast majority had concordant response or progression. We do believe that it's a biological phenomenon. The type of tumor that tends to go to the brain is going to be the type of tumor that will respond to whatever the regimen is that we're giving. In the previous trial also, we saw concordance of responses in the body and the brain. Dr. Davide Soldato Thank you very much. Just to highlight that really the combination is worth pursuing considering that there was not so much discordant responses, and the results, even in a phase 2 trial, were very, very promising. So thank you again, Dr. Kluger, for joining us today and giving us a little bit of insight into this very interesting trial. Dr. Harriet Kluger Thank you for having me. Dr. Davide Soldato So we appreciate you sharing more on your JCO article titled "Phase 2 Trial of Pembrolizumab in Combination with Bevacizumab for Untreated Melanoma Brain Metastases," which gave us the opportunity to discuss current treatment landscape in metastatic melanoma and future direction in research for melanoma brain metastasis. If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

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Beppe, a native Italian, started his journey in active travel over two decades ago and, with the help of his wife Heather, co-founded Tourissimo, one of the top adventure travel companies in Italy. With years of expertise designing cycling and adventure tours across all 20 regions of Italy, Beppe and Heather have the inside scoop on the most authentic and unforgettable experiences Italy has to offer.So grab your espresso (or a glass of vino Italiano), and let's explore Italy region by region!Northern Italy: Adventure, Culture, and Alpine BeautyLombardy (Lombardia)Running along the Swiss border, Lombardy is Italy's largest and wealthiest region—a land of striking contrasts and cultural riches. Home to nearly 10 million people, Lombardy contains 12 of Italy's largest cities: Milan, Bergamo, Brescia, Como, Mantua, Pavia, Cremona, Lecco, Lodi, Monza, Sondrio, and Varese. The region blends modern sophistication with old-world charm, from the fashion capital and bustling metropolis of Milan to the serene, postcard-perfect landscapes of Lake Como.Lombardy is dotted with some of Italy's most beloved lakes, including Lake Maggiore, Lake Como, Lake Garda, Lake Iseo, Lake Idro, and many more. Picturesque villages like Bellagio offer sun-drenched escapes along Lake Como's shores, while the medieval towns of Bergamo and Mantova enchant visitors with cobblestone streets, sweeping views, and centuries of history.Culinary lovers will be spoiled for choice with Lombardy's 60 Michelin-starred restaurants—3 with three stars, 6 with two stars, and 51 with one star. Be sure to savor the region's iconic Risotto alla Milanese, a creamy saffron-infused dish that's a local staple. Wine enthusiasts won't want to miss a glass of Franciacorta, Italy's sparkling answer to Champagne.November is a wonderful time to visit, with cooler temperatures and fewer tourists. It's also the perfect season to explore Lombardy's slice of the Alps, where charming mountain towns await nestled among the peaks. For an unforgettable adventure, consider attending the 2025 Winter Olympics, which will be held in Milan-Cortina d'Ampezzo!Tourissimo Tip– If you are flying into Milan, select the correct airport because Milan has two airports! For info, check out the following Tourissimo blog: https://www.tourissimo.travel/blog/avoid-this-common-travel-mistake-know-milans-two-airportsVenetoVeneto, the birthplace of Prosecco, Polenta, and the iconic Spritz, is a region rich in charm, culture, and culinary delights. Stretching from the Italian Riviera to the Venetian Pre-Alps and the stunning Dolomites, Veneto is home to both natural beauty and historic towns. Its capital, the enchanting floating city of Venice, is world-famous for its canals, gondolas, labyrinthine streets, and undeniable romance.Each of Venice's islands offers something special: admire the colorful houses of Burano, renowned for its lace-making traditions; visit Murano, celebrated for its centuries-old glassblowing artistry; and soak up the peaceful atmosphere of Torcello. Exploring these islands by vaporetto (water bus) offers a quieter, more authentic glimpse into Venetian life. Tourissimo Tip–For a few more suggestions, check out Tourissimo's blog on the Venetian Lagoon: https://www.tourissimo.travel/blog/our-favorite-destinations-in-the-venetian-lagoonBeyond Venice, Veneto boasts a treasure trove of picturesque towns. Verona, Padua, Vicenza, and Asolo each offer their own distinct history and beauty. Visit Castelfranco Veneto for a charming escape or head to Bardolino to enjoy a boat ride on Italy's largest lake, Lago di Garda. Stroll the waterfront in Castelletto sul Garda or circle the freshwater moat of Cittadella, a red-brick medieval town full of character.In the countryside, the hills of Prosecco promise stunning vineyard views, while the medieval town of Montagnana offers a taste of the past. Nature lovers can visit the volcanic Euganean Hills in Este, and cheese lovers shouldn't miss the small town of Asiago, home to one of Italy's most famous cheeses.Veneto's culinary scene shines with 34 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 29 with one star. Indulge in local specialties like Bigoli in Salsa, a hearty Venetian pasta with anchovy sauce, and toast with a glass of Prosecco, Grappa, or the regional favorite, the Select Spritz. And don't forget—Venetians love to celebrate, so let loose and join the party!Tourissimo Tips–Another fun suggestion is Veneto Marostica, the City of Chess, where they do a living chess match with hundreds of people dressed in medieval costumes every two years: https://www.tourissimo.travel/blog/marostica-the-city-of-chessPiedmont (Piemonte)Nestled at the foot of the Alps and bordered on three sides by the Mediterranean Sea, Piedmont is one of Italy's most underrated gems. With a diverse landscape that offers adventure and beauty year-round, this region is perfect for both winter skiing and summer hiking and biking, thanks to its stunning Alpine scenery.But Piedmont isn't just about breathtaking views—it's steeped in rich history and cultural significance. As the first capital of Italy, it boasts grand palaces, remarkable art, and sacred relics like the famed Shroud of Turin. The capital city of Turin is a vibrant hub, home to Europe's largest outdoor food market and the monthly Gran Balon flea market, a haven for vintage and antique lovers.Venture beyond the city and you'll discover a region bursting with charm and flavor. Tour the Langhe Hills, a paradise for vineyard visits, and sample Bagna Cauda, a warm anchovy and garlic dip beloved by locals. Wander the lakeside town of Stresa on Lake Maggiore, or stroll the cobbled streets of Neive, where views of rolling hills and storybook cottages create an unforgettable setting. In Asti, you can witness the September medieval horse races and visit the majestic Cattedrale di Santa Maria Assunta e San Gottardo. For a true fairy-tale escape, head to Macugnaga in the valley of Monte Rosa, a perfect base for both skiing and hiking. And just outside of Turin lies the hidden gem of Lake Orta, a peaceful retreat away from the crowds.Piedmont's culinary scene is just as spectacular. With 35 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 30 with one star—the region is a paradise for food lovers. Dine in Alba during white truffle season (September to January), and savor iconic regional dishes like Agnolotti del Plin and Coniglio Arrosto. Wine enthusiasts will be in heaven here—Piedmont is the land of Barolo, the "king of wines," and Barbaresco, two of Italy's most prestigious reds.Tourissimo Tips:Piedmont is home to the Slow Food movement: https://www.tourissimo.travel/blog/why-piedmont-is-renowned-for-its-slow-foodTourissimo Tip–Check out this blog for a guide to a day of eating in Turin: https://www.tourissimo.travel/blog/a-day-of-eating-in-turinTourissimo Tip–One of the Best Meals of Your Life will be at the Piazza Duomo in Alba!Emilia-RomagnaLocated in central Italy along the Adriatic coast, Emilia-Romagna is a vibrant and diverse region known for its perfect blend of “slow food” and “fast cars.” This area is considered both the culinary and automotive capital of Italy, offering rich traditions, warm hospitality, and unforgettable experiences.Food lovers will be in heaven here. Emilia-Romagna is the birthplace of iconic Italian delicacies such as Mortadella, Tortellini in Brodo, Parmigiano-Reggiano, Prosciutto di Parma, traditional Balsamic Vinegar, Lambrusco, and egg-based fresh pastas like lasagna, tortellini, and tagliatelle. A visit to Parma lets you savor authentic Parmigiano-Reggiano and world-class Prosciutto, as well as enjoy the elegant Teatro Regio opera house.The region also has a need for speed—it's home to legendary automotive brands like Ferrari, Lamborghini, and Maserati. For car enthusiasts, the Ferrari Museum in Modena is a must-see. Emilia-Romagna even has a dedicated cycling tourism office, and in summer 2023, it played host to several stages of the Tour de France, which began in nearby Florence.Beyond the food and cars, Emilia-Romagna offers a range of enchanting destinations. The capital city of Bologna is known for its Piazza Maggiore, the Two Towers, and the scenic Santuario Madonna di San Luca. In Ravenna, marvel at the dazzling, colorful mosaics and the historic San Vitale Basilica. Along the coast, vibrant seaside resorts like Cervia, Cesenatico, and Rimini create a lively, carnival-like party atmosphere from late May through September. For a more peaceful experience, explore the medieval gem of Brisighella, a lesser-known treasure full of charm.When it comes to fine dining, Emilia-Romagna doesn't disappoint. The region boasts 24 Michelin-starred restaurants, including one three-star, three two-star, and twenty one-star establishments. Visitors are often struck by the warmth and generosity of the locals—some of the most hospitable people in Italy—who express their love through exceptional food and outstanding service.Tourissimo Tips:Did you know that there is a whole other country within Emilia Romagna? https://www.tourissimo.travel/blog/san-marino-the-other-small-country-within-italyTourissimo Tip–Pietra di Bismantova was an inspiration for Dante: https://www.tourissimo.travel/blog/pietra-di-bismantova-the-inspiration-for-dantes-purgatoryTourissimo Tip–You can cross the Rubicon: https://www.tourissimo.travel/blog/crossing-the-rubiconTrentino-South TyrolNestled along Italy's northern border with Switzerland, Trentino–South Tyrol is a stunning mountainous region that blends Italian and Austrian influences, making it a top destination for nature lovers and outdoor enthusiasts. With its striking Alpine scenery, exceptional cuisine, and rich cultural duality, this region offers the best of both worlds.The South Tyrol capital, Bolzano, is renowned for having the highest quality of life in Italy, combining the clean, efficient infrastructure often associated with Germany with the flavorful food and spirited lifestyle of Italian culture.Outdoor adventurers will be captivated by the Dolomites, with their dramatic limestone peaks—ideal for hiking, skiing, and breathtaking vistas. Don't miss the Alpe di Siusi, Europe's largest Alpine meadow, which is especially stunning in spring and summer. Explore shimmering Lake Garda and uncover the region's medieval past through spectacular castles like Schloss Tirol, Castel Roncolo, and Castel d'Appiano.Tourissimo Tip–An off-the-beaten-path outdoor paradise can be found in the Alps of Trentino. Check out the Val di Sole. This is one of the areas that Beppe and Heather regularly go to on their personal vacations in Italy: https://www.tourissimo.travel/blog/the-wild-dolomitesThe culinary offerings here reflect the region's unique blend of cultures. Traditional dishes range from Bratwurst and Goulash to Italian-style pastas with hearty meats like deer. Foodies should try Speck, a savory smoked ham, perfectly paired with a glass of Gewürztraminer, a fragrant white wine native to the area. The region also produces excellent white wines and lighter reds that pair beautifully with its alpine cuisine.When it comes to fine dining, Trentino–South Tyrol excels with 33 Michelin-starred restaurants, including three three-star, five two-star, and twenty-five one-star establishments, making it one of Italy's most impressive gourmet regions.LiguriaLocated along Italy's rugged northwestern coastline, Liguria—also known as the Italian Riviera—boasts dramatic cliffs, colorful seaside villages, and incredible culinary traditions. The region is best known for the five picturesque villages of Cinque Terre, as well as the glamorous resort towns of Portofino and Santa Margherita Ligure.Tourissimo Tip– If you visit the Cinque Terre, don't forget to look up, and hike up away from the crowds to see the heroic vineyards: https://www.tourissimo.travel/blog/the-heroic-winemaking-of-the-cinque-terreBecause of the narrow, winding roads with steep drop-offs, many travelers prefer to explore the region via the local train or by public or private boat. If you're planning to hike the famous trails, be aware that entrance permits are now required due to landslides and overtourism.In the regional capital of Genoa, dive into maritime history, visit the iconic San Lorenzo Cathedral, and wander the city's old port area. Just outside Genoa, discover the secluded San Fruttuoso Abbey, accessible only by boat or footpath. In Vernazza, one of the Cinque Terre towns, visit the Doria Castle and the beautiful Santa Margherita Church.Liguria is also a celebrity hotspot, and its cuisine is just as impressive as its scenery. Known as the birthplace of pesto, the region is famous for Pesto alla Genovese, made with a special local basil. Be sure to try the region's olive oil, garlic, cheeses, and exceptional seafood, especially the anchovies. Other regional specialties include Focaccia di Recco, a cheese-filled flatbread, and lighter olive oils that perfectly complement Ligurian dishes.For fine dining, Liguria is home to seven Michelin-starred restaurants, all with one star, offering refined cuisine rooted in the region's coastal and agricultural traditions.Friuli-Venezia Giulia (Friuli)Tucked between Veneto, Austria, and Slovenia, Friuli-Venezia Giulia is a lesser-known gem that offers a unique blend of Alpine landscapes, rich cultural heritage, and coastal charm. The region features part of the Dolomites, ideal for hiking, skiing, and capturing breathtaking scenery.The capital, Trieste, is a refined port city with a fascinating blend of Italian, Austro-Hungarian, and Slavic influences. Don't miss the Miramare Castle, perched over the sea with stunning views. In Cividale del Friuli, stroll through cobbled streets and sample Frico, a savory, crispy dish made of cheese and potatoes, best enjoyed with a glass of Schioppettino, a bold red wine native to the region.For outdoor adventures and relaxation, spend a beach day at Lignano Sabbiadoro, camp in Sistiana, bike the trails around Grado, or explore the ancient Roman ruins in Aquileia, a UNESCO World Heritage Site. Be sure to visit the enormous Grotta Gigante (Giant Cave), stroll through Unity of Italy Square, and tour the Revoltella Museum for modern art.Friuli-Venezia Giulia is also home to seven Michelin-starred restaurants, including two two-star establishments and five one-star venues, reflecting the region's quiet but impressive culinary scene.Tourissimo Tip– A hotel that Heather and Beppe love in Cormons is La Subida. It's a unique, high-end, and rustic property nestled in nature that boasts a 1-Michelin star restaurant: https://www.tourissimo.travel/blog/hotels-we-love-la-subidaAosta ValleyNestled in the northwestern tip of Italy, where it borders Switzerland and France, the Aosta Valley is Italy's smallest and highest region—a true mountain paradise. This alpine jewel is renowned for its dramatic snowcapped peaks, storybook castles, and a unique blend of French and Italian culture, as both languages are spoken here.The region is home to Mont Blanc (Monte Bianco), Europe's highest peak, which straddles the borders of Italy, France, and Switzerland. While the summit lies on the French side, visitors on the Italian side can experience the Skyway Monte Bianco, a breathtaking cable car ride offering panoramic views of the Alps.Key landmarks include the striking Matterhorn, the impressive Fénis and Savoy Castles, and the Bard Fortress, one of the largest and most remarkable fortifications in the Alps. After a day in the mountains, relax in one of the region's thermal spas, and indulge in Fonduta, a rich, velvety cheese fondue perfect for chilly alpine evenings.Wine lovers should sample the region's distinctive red mountain wines, especially Enfer d'Arvier, known for its bold flavor and high-altitude character.Tourissimo Tip–A fun tradition is the Friendship Cup, a communal cup of coffee: https://www.tourissimo.travel/blog/the-friendship-cup-of-valle-daostaCentral Italy: History, Art, and Rolling HillsTuscany (Toscana)Tuscany, the heart of the Renaissance, is a captivating region of rolling hills, cypress-lined roads, vineyards, and timeless art and architecture. Located just below Italy's northern regions, it's a haven for art lovers, history buffs, and food and wine enthusiasts alike. From Chianti to Brunello di Montalcino, the region offers a wide variety of world-class wines.The regional capital, Florence, is one of Italy's most walkable and safe major cities, making it ideal for solo travelers. Admire its architectural wonders while sipping on Chianti Classico and indulging in a local favorite—Bistecca alla Fiorentina. Must-see landmarks in Florence include the Cathedral of Santa Maria del Fiore (Duomo), Ponte Vecchio, Palazzo Vecchio, the Uffizi Gallery, and the Galleria dell'Accademia, home to Michelangelo's David. For iconic views, head to Piazzale Michelangelo.Beyond Florence, explore the historic cities of Siena, Lucca, and San Gimignano, each offering its own charm. Don't miss the Leaning Tower of Pisa or the Siena Cathedral, and spend time in the picturesque public squares like Piazza del Campo, Piazza della Signoria, and Piazza del Duomo.For off-the-beaten-path adventures, discover medieval hilltop villages such as Sorano, or head to the Maremma coast for scenic beaches and bold wines. Tuscany also shines in its culinary excellence, boasting 41 Michelin-starred restaurants—including 1 three-star, 5 two-star, and 35 one-star establishments.Tourissimo Tip–3 places in Tuscany you didn't know existed: https://www.tourissimo.travel/blog/three-places-in-tuscany-you-did-not-know-existedUmbriaUmbria, often called the "Green Heart of Italy," is the country's only completely landlocked region, nestled between Tuscany, Lazio, and Le Marche. Though it lacks large cities, Umbria more than makes up for it with breathtaking natural beauty, medieval towns, and a rich culinary tradition.One of Umbria's most impressive sights is the Cascata delle Marmore (Marmore Falls)—the second tallest waterfall in Europe. Nature lovers and photographers alike will be amazed by its dramatic 165-meter drop. The region is also home to Assisi, the birthplace of St. Francis, one of Italy's most revered saints, and a major pilgrimage destination.Food lovers will delight in Umbria's hearty, earthy cuisine, featuring lentils, mushroom-based dishes, cured meats, and the prized black truffle (Tartufo Nero di Norcia). Pair these specialties with a glass of Sagrantino di Montefalco, a robust red wine unique to the region.Umbria's culinary excellence is further reflected in its four Michelin-starred restaurants: Casa Vissani, Vespasia, Ada, and Elementi. Each holds one Michelin star, offering refined takes on the region's rustic flavors.Tourissimo Tip–Norcia is definitely one of Italy's culinary gems: https://www.tourissimo.travel/blog/norcia-one-of-italys-culinary-gemsMarcheLocated in central Italy on the Adriatic side, Marche is a beautiful region with a population of 1 million people, known for its charming towns, rich history, and welcoming, hardworking culture. The region offers stunning destinations like Urbino and Ancona, along with pristine beaches such as Spiaggia della Due Sorelle, Parco Naturale Monte San Bartolo, Mezzavalle, and the Riviera del Conero, not to mention many picturesque nature reserves.Must-see landmarks include Castello di Gradara, Palazzo Ducale di Urbino, the Sanctuary of the Holy House of Loreto, Cattedrale di San Ciriaco, Tempio del Valadier, and the breathtaking underground Frasassi Caves. Marche's favorite cities and nearby towns also include Gubbio, Assisi, Perugia, Orvieto, and Cascia.For those drawn to religious history, highlights include the Papal Basilica of Saint Francis, the Sacred Convent of Saint Francis, Basilica di Santa Maria degli Angeli, and Basilica di Santa Chiara in Assisi, as well as the Basilica of Santa Rita da Cascia. History lovers should visit Rocca Paolina, Piazza IV Novembre, Fontana Maggiore, Piazza del Comune, and Grotta di Monte Cucco, while museums like Narni Sotterranea, the National Gallery, and Nobile Collegio del Cambio offer rich cultural experiences.This region is famous for its culinary tradition, especially its mastery of seafood, and is home to seven Michelin-starred restaurants — including Uliassi in Senigallia, proudly holding three Michelin stars, along with one two-star and five one-star establishments. No visit would be complete without tasting Olive all'Ascolana, fried stuffed olives that perfectly capture Marche's local flavor. All of this, combined with the region's natural beauty and warm, fun, and friendly locals, makes Marche a truly unforgettable destination in the heart of Italy.Tourissimo Tip–Ascoli Piceno, the town where the Ascoli olive is from, is beautiful, especially at night when it appears to glow: https://www.tourissimo.travel/blog/ascoli-piceno-the-italian-town-that-glows-at-nightLazioLazio, one of Italy's central regions, though often considered a southern region by Italians, is a place rich with history, iconic landmarks, and hidden gems. At its heart is the capital city of Rome, a destination overflowing with opportunities for exploration. Essential sites include the Colosseum, Trevi Fountain, Pantheon, Roman Forum, Spanish Steps, St. Peter's Basilica, the Sistine Chapel, and countless other remarkable attractions. No visit to Rome is complete without savoring its famous dishes, including Cacio e Pepe — a creamy cheese and pepper pasta — along with local favorites like Spaghetti alla Gricia, Pasta all'Amatriciana, and Pasta Carbonara, best enjoyed with a glass of crisp Frascati wine while taking in views of the Colosseum. Lazio as a whole has 107 two-star Michelin restaurants and 105 one-star restaurants. If you find yourself in the Trastevere neighborhood, there are many wonderful popular restaurants, including La Scaletta and Le Mani in Pasta.Another must-see is Vatican City, home to the Vatican and its world-renowned religious and artistic treasures. In December 2025, Rome will host the Jubilee, or Holy Year — a significant Catholic Church event focused on forgiveness, reconciliation, and spiritual renewal, held only once every 25 years and drawing pilgrims from across the globe.Beyond Rome, Lazio offers a beautiful coastline and peaceful countryside, perfect for travelers seeking quieter escapes. Among its hidden gems is Ostia Antica, an ancient Roman city that once served as the bustling port of Rome, located at the mouth of the Tiber River. With its blend of legendary landmarks, culinary traditions, religious significance, and off-the-beaten-path treasures, Lazio is a captivating region waiting to be explored.Tourissimo Tip–There's a wonderful project underway to create a cycle path around the perimeter of Rome: https://www.tourissimo.travel/blog/cycling-in-rome-grab-a-bike-and-bike-the-grabAbruzzoAbruzzo, known as Italy's green region, lies in the central-eastern part of the country and boasts a stunning combination of mountains, coastline, and unspoiled nature. Along the beautiful Trabocchi Coast, visitors can admire the historic trabocchi — ingenious wooden fishing structures built by fishermen centuries ago to safely fish the Adriatic waters, many of which have now been converted into charming seaside restaurants where you can dine on fresh seafood while suspended above the waves with sunsets as your backdrop. When it comes to dining, Abruzzo currently boasts four Michelin-starred restaurants; there are three 1-star restaurants and one 3-star restaurant. Food lovers shouldn't miss Arrosticini, the region's famous grilled lamb skewers, or a glass of bold Montepulciano d'Abruzzo red wine. Outdoor enthusiasts have countless opportunities for adventure, from swimming at the Stiffe Caves and strolling the Ponte del Mare to relaxing on the beaches of Riserva Naturale Guidata Punta Aderci and hiking to the iconic Rocca Calascio. Lakeside escapes await at Lago di Scanno and Lago di Barrea, while the towering Gran Sasso d'Italia and the expansive Parco Nazionale d'Abruzzo, and Lazio e Molise offer breathtaking scenery and pristine trails. The region is home to many national parks — Abruzzo, Lazio, Molise National Park, Gran Sasso and Laga Mountains National Park, and Maiella National Park — perfect for hiking, biking, trail running, and spotting the highest peaks of the Apennine Mountain Range. Cyclists can enjoy the Bike to Coast cycle path, a 131 km (81.4 mile) route running along the Adriatic coast from Pescara to Vasto. History and architecture lovers will appreciate sites like Basilica di Santa Maria di Collemaggio, Centro Storico di Sulmona, Santo Stefano di Sessanio, Abbey of San Giovanni in Venere, and the Medieval Village of Pacentro. For a uniquely tranquil experience, visit the enchanting Gardens of Ninfa. Abruzzo is also a fabulous winter skiing destination and keeps traditions alive with events like Transumanza, the seasonal migration of livestock, primarily sheep, between the high-altitude pastures of the region. With its mountain majesty, historic villages, flavorful cuisine, and coastal charm, Abruzzo offers something unforgettable for every traveler.Tourissimo Tips:More info on the trabocchi coast: https://www.tourissimo.travel/blog/abruzzos-trabocchi-coastAbruzzo Bike to Coast is a beautiful bike path along the coast: https://www.tourissimo.travel/blog/cycling-along-abruzzos-coastMoliseOne of Italy's most untouched and lesser-known regions, Molise is famously nicknamed “the region that doesn't exist,” though it's rich in history, traditions, and natural beauty. This quiet region offers a mix of beaches and mountains, including part of the National Park of Abruzzo within the Apennines mountain range, filled with abundant wildlife, hiking trails, and winter ski opportunities. Tourissimo Tip–The Region That Doesn't Exist: https://www.tourissimo.travel/blog/the-italian-region-that-doesnt-existThe capital city, Campobasso, is home to notable sites like Monforte Castle and several Romanesque churches, while the charming coastal town of Termoli draws visitors for its beaches, trabucchi (historic fishing huts now serving fresh seafood), and local specialties like brodetto, a traditional seafood stew. Along the Molise coast in Termoli, dining at a trabucchi offers fresh catches with a side of Adriatic views. History buffs should visit the Samnite ruins in the Pietrabbondante archaeological area, the well-preserved Saepinum Archaeological Area, and landmarks like Lago di Castel San Vincenzo, the Cathedral of Saint Mary of the Purification, Monforte Castle, and the Basilica of Saint Mary of Sorrow. A must-see is the Marinelli Bell Foundry, founded in 1339. It's the oldest continuously operating bell foundry in the world, Italy's oldest family business, and the official provider of bells to the Vatican. Food lovers can sample Cavatelli, a local pasta specialty, paired with Tintilia, a rare red wine unique to Molise. The region is also home to seven one-star Michelin restaurants and several local food tours that showcase its rustic culinary traditions. While Molise's quiet charm and untouched landscapes make it a special destination, visitors should note that English is not widely spoken, making it a truly authentic Italian experience for those eager to explore one of the country's hidden gems.Southern Italy: Sun, Sea, and Ancient WondersCampania The birthplace of Neapolitan pizza, the Mediterranean Diet, and Mozzarella di Bufala, Campania is one of Italy's most vibrant and culturally rich regions. Home to the bustling regional capital Naples (Napoli), it boasts some of the country's most iconic destinations, including Pompeii, the stunning Amalfi Coast, and the tranquil Cilento Coast.Along the sparkling, deep-blue waters of the Golfo di Napoli, you'll find must-visit coastal towns like Positano, Amalfi, and Ravello, as well as the famous islands of Ischia, Capri, and the colorful Procida. Visitors can hike the breathtaking Path of the Gods, explore the hauntingly preserved ruins of Archaeological Pompeii, forever shadowed by the gray cone of Mt. Vesuvius, and savor the region's culinary gems like ultra-fresh seafood and crisp Falanghina wine.History and culture lovers shouldn't miss Sansevero Chapel Museum, San Carlo Theatre, the Catacombs of San Gennaro, and the lush Villa Cimbrone Gardens. Campania also impresses with its historic castles, including the Royal Palace of Caserta, Ovo Castle, and Castello Aragonese d'Ischia. Wine enthusiasts should head to the province of Avellino, known for producing some of the best wines in southern Italy.Tourissimo Tip–Wine is also grown inland on the Amalfi Coast, and there are some vines that are 250 years old (pre-phylloxera): https://www.tourissimo.travel/blog/old-vines-on-the-amalfi-coastNature lovers will be drawn to the Cilento, Vallo di Diano, and Alburni National Park, a UNESCO World Heritage Site celebrated for its biodiversity, dramatic landscapes, and cultural heritage, featuring ancient ruins like Paestum and Velia, the majestic Padula Charterhouse, and idyllic coastal villages.Campania is also a paradise for food lovers, home to 51 Michelin-starred restaurants, including one three-star, eight two-star, and forty-two one-star establishments. From world-famous landmarks to hidden treasures, Campania offers an irresistible blend of history, nature, food, and coastal charm.CalabriaWith its rugged coastlines, dramatic landscapes, and hidden treasures, Calabria is a must-visit region in southern Italy. Known for its bold flavors and rich culinary traditions, visitors should sample 'Nduja, a spicy, spreadable sausage paste, and the region's famous Calabrian chiles. The local cuisine embraces cucina povera, a tradition of simple, hearty dishes featuring handmade pasta made with just flour and water. Calabria offers a growing fine dining scene with six one-star Michelin restaurants. For nature lovers, Calabria is home to three stunning national parks — Sila, Aspromonte, and Pollino — ideal for hiking, wildlife spotting, and immersing in untouched landscapes. Along the coast, Capo Vaticano stands out as one of the world's most beautiful beaches, offering breathtaking views and crystal-clear waters. History buffs and castle enthusiasts can explore impressive fortresses like Castello Ruffo di Scilla, Castello Murat, Castello di Le Castella, and Castello Aragonese. Don't miss charming towns and villages such as Tropea, famous for its clifftop views and beaches, as well as Scilla, Pentedattilo, and Le Castella. With its authentic culture, stunning coastlines, flavorful cuisine, and rich history, Calabria remains one of Italy's most captivating yet underrated regions.Tourissimo Tip–Way off the beaten path, lies a  unique museum in Mammola, Calabria https://calabriastraordinaria.it/en/news/visit-to-musaba-the-sistine-chapel-of-calabriaPugliaKnown as the Maldives of Italy, Puglia is a sun-drenched region celebrated for its whitewashed hill towns, ancient olive groves, and miles of stunning coastline. With a dry Mediterranean climate and scenery that often feels more Greek than Italian, Puglia is famed for its beaches in Salento, crystal-clear waters, and charming seaside towns. One of its most iconic sights is the fairytale-like trulli houses of Alberobello, a UNESCO World Heritage Site. This region is also a food lover's paradise, offering specialties like Orecchiette pasta with turnip greens, the classic Fave e Cicoria (fava bean purée with wild chicory), and fresh seafood paired with crisp vegetables. Wine lovers can savor Primitivo, a bold local red. For fine dining, the region boasts nine one-star Michelin restaurants, blending rustic flavors with refined culinary creativity.Puglia is dotted with unique cities and towns worth exploring, including Locorotondo, Otranto, Lecce, Monopoli, Ostuni, Gallipoli, Bari, Alberobello, and Polignano a Mare. Nature and history enthusiasts will enjoy visiting extraordinary sites like the Grotte di Castellana, the dramatic Cave of Poetry, the ancient Basilica San Nicola, and the scenic Gargano Peninsula. With its thousand-year-old olive trees, Puglia is the largest olive oil producer in the world, known for its strong, spicy oils. The locals here are famously warm and welcoming, going out of their way to make visitors feel at home.Puglia's blend of natural beauty, rich tradition, and heartfelt hospitality makes it one of Italy's most captivating and underrated destinations.Tourissimo Tip–Here are some of the gems of Puglia: https://www.tourissimo.travel/blog/some-of-the-gems-of-pugliaBasilicataBasilicata, a remote yet captivating region with a population of just 500,000, offers a wealth of unique experiences despite its secluded location. Among its most intriguing destinations are the ghost town of Craco and the ancient cave city of Matera, both steeped in history and cinematic charm. Other towns worth visiting include Maratea and Palombaroa, each offering its own cultural and scenic appeal.Tourissimo Tip–Matera is magical! https://www.tourissimo.travel/blog/destination-highlight-matera-the-city-of-stonesThe region is rich in historical and religious landmarks, such as the Crypt of Original Sin with its remarkable frescoes, and the medieval Melfi Castle. Don't miss the towering Statue of Christ the Redeemer in Maratea, a striking monument that overlooks the Tyrrhenian coast.For a taste of local flavor, try Peperoni Cruschi—crispy, sun-dried peppers that are a beloved regional delicacy. Basilicata is also known for its exceptional wines, especially the bold, full-bodied reds of Aglianico del Vulture DOC, made primarily from the Aglianico grape. White wine lovers will appreciate the region's Greco di Tufo and Fiano varietals as well. Basilicata also has a total of 14 one-star Michelin restaurants. Adventurers can experience an adrenaline rush on The Angel's Flight, a giant zip line that offers stunning views and a thrilling ride through the Lucanian landscape.SicilySicily, the largest island in the Mediterranean Sea, is a world of its own, offering a diverse landscape of coastlines, mountains, and magical towns such as Cefalù, Palermo, Taormina, Catania, Noto, Agrigento, and Syracuse. Palermo serves as the cultural and diplomatic capital of the region, while Catania stands as its business hub.A volcanic island and UNESCO World Heritage Site, Sicily boasts a rich collection of cultural and natural treasures. Highlights include the awe-inspiring Valley of the Temples, the active volcano Mount Etna, the stunning Duomo di Cefalù, and the picturesque islands of Stromboli, Bella, and Ortigia. The region is also home to the renowned Baroque Triangle in the Val di Noto region of southeastern Sicily, where the eight towns of Caltagirone, Militello Val di Catania, Catania, Modica, Noto, Palazzolo Acreide, Ragusa, and Scicli have been recognized by UNESCO for their outstanding examples of late Baroque architecture.Sicily's culinary scene is just as impressive. Indulge in traditional Sicilian cannoli, filled with sheep's milk ricotta cheese and always stuffed fresh to order. Take a street food tour to savor local favorites like arancini, and don't miss sipping on a glass of Nero d'Avola, one of Sicily's most famous wines. The region is also internationally celebrated for its top-tier agriculture and winemaking.For a taste of authentic Italian charm beyond the tourist trail, explore the towns featured in I Borghi Più Belli d'Italia—Italy's list of its most beautiful hidden gems. Tourissimo Tip–This is a great tip for all 20 regions of Italy. Find out more here: https://www.tourissimo.travel/blog/the-most-beautiful-small-towns-in-italyFood lovers will be delighted to know that Sicily is also home to 23 Michelin-starred restaurants, including three two-star establishments and twenty with one star.Tourissimo Tip–If you visit Corleone, you should definitely learn about the legacy of the Mafia. We in North America tend to have a romanticized view of the mafia, but for the locals, the history is more brutal. See some photos and learn more here: https://www.tourissimo.travel/blog/letizia-battaglia-groundbreaking-photojournalist-who-fearlessly-documented-the-mafia-in-her-native-sicilySardiniaSardinia, the second-largest island in the Mediterranean after Sicily, is a rugged, rural paradise known for its natural beauty, deep-rooted traditions, and ancient history. The island is home to features like the Apennine Coast, the Adriatic Coast, and the Apennine Mountains. Most of Sardinia's population lives in the capital region of Cagliari, but much of the island remains untouched, offering visitors a glimpse into authentic Italian island life.One of Sardinia's most fascinating distinctions is that the Barbagia region is recognized as a Blue Zone—an area with an unusually high number of centenarians. This longevity is attributed to the region's healthy diet, active lifestyle, and strong sense of community. For outdoor enthusiasts, inland Sardinia offers some of the best biking and hiking experiences in all of Italy.Tourissimo Tip–What is a Blue Zone? https://www.tourissimo.travel/blog/blue-zoneThe island's coastlines are just as enticing. Costa Smeralda is often described as paradise on earth, with stunning beaches like Spiaggia di Tuerredda, Cala Goloritzé, and Spiaggia di Porto Giunco perfect for sunbathing and swimming. Don't miss the La Maddalena Archipelago National Park (Parco Nazionale dell'Arcipelago di La Maddalena), a protected area with crystal-clear waters and pristine landscapes.Charming towns such as Alghero, Bosa, and Cagliari add to the island's appeal. Many of Sardinia's towns are nestled in the mountains located in the island's center, offering a peaceful and scenic escape.Cultural and historical attractions abound. Must-see sites include the Nora Archaeological Park, Bastione di Saint Remy, Parco Archeologico Naturalistico di Santa Cristina, and the Museo Archeologico Nazionale di Cagliari. For an unforgettable natural wonder, venture into the Frecce delle grotte srl and Neptune's Grotto, stunning sea caves accessible by boat or stairs carved into cliffs.Sardinia is also home to a unique ancient civilization. Scattered across the island are over 7,000 nuraghe—megalithic stone structures built during the Nuragic Age (c. 1900–730 BC). These mysterious, tower-like buildings are the island's most iconic symbol, and some scholars believe there were once over 10,000 nuraghe structures in total.Religious architecture also impresses, with highlights like the Cattedrale di Santa Maria Assunta e Santa Cecilia, the Church of the Holy Trinity of Saccargia, and the Basilica di San Simplicio showcasing Sardinia's spiritual and artistic heritage.Sardinian cuisine reflects its mountainous geography. Surprisingly, for an island, the diet leans more toward land-based ingredients than seafood. Signature dishes include Porceddu (roast pig), Fregola (a traditional Sardinian pasta), and the adventurous Casu marzu—a sheep's milk cheese intentionally infested with live maggots and considered a local delicacy. Sardinia also holds 16 one-star Michelin restaurants.To accompany these flavors, try a glass of Cannonau red wine, known for its high polyphenol content and potential health benefits, or the refreshing Vermentino white wine, perfect for warm Mediterranean days.Tourissimo Tip–Magic Trick or Pasta Making? https://www.tourissimo.travel/blog/magic-trick-or-pasta-making From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio!From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio! 

Join Oliver and Anthony as they recap a third win on the spin against Genoa and preview the dress rehearsal of the Coppa Italia final against Bologna.This week's topics include… ↳ Maignan Magic at the Marassi↳ Leao, Gimenez and Joao Felix change the game↳ Bologna: Act I↳ Sporting director latest and listener questions This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sempremilan.substack.com/subscribe

Il #milan vince 2-1 a #genova contro il #genoa in #seriea in una partita senza peso e senza obiettivi , ma Sergio #conceicao infila la terza vittoria consecutiva.Diventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.

«Siamo alla vigilia di un’invasione massiccia di Gaza, secondo le raccomandazioni dello Stato maggiore», così il Primo Ministro israeliano Benjamin Netanyahu in un video pubblicato sui suoi account social. Parliamo di questo e delle ultime notizie che arrivano dal Medio Oriente con Giuseppe Dentice, analista OSMED – Osservatorio sul Mediterraneo.Al via oggi il processo contro Sean Combs, il rapper noto come Puff Daddy. Con noi Veronica Maffei, collaboratrice da Los Angeles.Altri arresti nelle curve di Milano: in sette fra ultras di Inter e Milan. Ne parliamo con Pierpaolo Romani, coordinatore nazionale di Avviso Pubblico, ha lavorato all’interno della commissione parlamentare d’inchiesta sul fenomeno delle mafie nel gruppo di lavoro su “Mafia e Calcio” e autore di “Calcio criminale” (Pierpaolo Romani, Rubettino).Questa sera in campo Genoa contro Milan. Tutti gli aggiornamenti da Giovanni Capuano.

Il #milan questa sera sfida il #genoa in #seriea ma è già proiettato al #bologna : sia per la finale di #coppaitalia , sia per le voci che riguardano Vincenzo #italiano come prossimo allenatore #rossoneroDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.

Questa sera contro il Genoa si vedrà la formazione che affronterà il Bologna in finale di Coppa Italia (mentre venerdì, sempre contro il Bologna ma in campionato, ci sarà ampio turnover).Diventa un supporter di questo podcast: https://www.spreaker.com/podcast/radio-rossonera--2355694/support.

The end of Summer: Alison Lanier leaves Y&R!; Sally and Chelsea double quit Marchetti; Lauren warns Michael about Victor; Call an ambulance for Cole!; Mariah returns… with a secret!; and Billy tells Diane he hates the mansion redo! Hey everybody! Why not pick up a bonus Y&R Chat episode at: http://www.GenoaCitySoap.com I love hearing from […]

Six-Time James Beard Finalist, Cathy Whims, of Portland's Nostrana, on her new book.Welcome back to Pizza Quest!This week we welcome six-time James Beard Award finalist, Chef Cathy Whims, owner of Portland's beloved restaurant, Nostrana. which celebrates its 20th anniversary this year. I first met Cathy when she was the chef and co-owner of Portland's celebrated fine dining Italian restaurant Genoa, where I enjoyed a memorable six-course tasting menu along with the famous bread book author, Carol Field (The Italian Baker). That was over 25 years ago. Genoa closed a few years later, and Nostrana emerged, but it's quite different from Genoa, serving wonderful rustic Italian food and Neapolitan pizzas to its large and loyal following. This month also marks the publication of Cathy's first book,The Italian Summer Kitchen, full of wonderful, easy-to-make recipes as well as the stories behind them.I felt like we were all so young when we first met (and Cathy is still far younger than I), but now it feels like we're like the surviving old timers. I remember reading the sobering news when Carol Field passed away eight years ago -- she was an esteemed mentor to many of us, and now we've inherited that same mentorship mantle for the next generation, which is why Cathy's new book is so important.  We'll hear all about her long journey from Chapel Hill, NC on her way to becoming hailed, as one writer called her, the unofficial Doyenne of Italian cooking for the Pacific Northwest. It's all here in this week's edition of Pizza Quest.

Storie di Calcio - Simone Braglia, Stefano Eranio, Fulvio Collovati e Bruno Longhi ricordano Liverpool Genoa 1992 a Marco Piccari

Join Oli and Anthony as they recap the derby demolition of Inter to reach the Coppa Italia final, another clean sheet vs. Venezia and the trip to Genoa. This week's topics include… ↳ Five derbies unbeaten = cup final!↳ Coasting by the lagoon against Venezia↳ Vieira's Genoa await↳ 3-4-3 system and trophy preference This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sempremilan.substack.com/subscribe

0:00 Milan Beat Venezia 02:25 Pulisic Balls Out20:00 Conceicao Staying? 26:40 Santi Gimenez Scores 45:30 Genoa Preview Twitters:https://twitter.com/ThatMilanPodhttps://twitter.com/Matt_Santangelohttps://twitter.com/MartinoPuccioOther Channel: https://www.youtube.com/@ThatMilanPod

The Abbott Mansion Refresh: Like it or Not?; Adam propose to Chelsea… to be his COO; Tessa teaches Daniel to play guitar; Billy tries to replace Phyllis with Sally; Holden asks Audra for a job; Amy leaves GC for treatment in Boston; Cole coughs, and Kyle and Claire say their first I love yous. Hey […]

The Premier League could be decided this weekend and we have the FA Cup Semis & Copa Del Rey to breakdown Andrew Passaro and Nick Dianni get you ready for the weekend and discuss all of their favorite bets and parlaysFollow Nick:https://twitter.com/NickDianniFollow Andrew https://twitter.com/theplusmoneypod⁠⁠https://twitter.com/AndrewPassaro⁠⁠https://www.instagram.com/theplusmone..⁠.⁠https://www.instagram.com/andrewpassaro/⁠sign up for our newsletter: https://plus-money.beehiiv.com/subscribeTIME CODESINTRO 0:00-2:21Wolves vs Leicester 2:21-5:27Crystal Palace vs Aston Villa 5:27-8:49Nottingham Forest vs Manchester City 8:49-11:37Barcelona vs Real Madrid 11:37- 16:49Como vs Genoa 16:49-17:54Inter Milan vs Roma 17:54-21:58Hoffenheim vs Dortmund 21:58-22:48BTTS Parlay 22:48-26:14

In this episode, we dive into Lazio's 2-0 win over Genoa, highlighted by a stunning goal from Taty Castellanos. Hosted on Acast. See acast.com/privacy for more information.

Former Dublin Ladies Football boss Mick Bohan is here in studio joined by his former goalkeeper Ciara Trant - as well as Ger Gilroy!- 2009, Six Nations Grand SlamParc des princes, Ireland v France.- Italia 90, Genoa, Ireland v Romania.- 2024, Clare hurling final, Feakle v Sixmilebridge.- 2025, Orlando Magic v Atlanta Hawks.- 2017, All-Ireland Final, Dublin v Mayo.Catch The Off The Ball Breakfast show LIVE weekday mornings from 7:30am or just search for Off The Ball Breakfast and get the podcast on the Off The Ball app.SUBSCRIBE at OffTheBall.com/joinOff The Ball Breakfast is live weekday mornings from 7:30am across Off The Ball

Beppe, a native Italian, started his journey in active travel over two decades ago and, with the help of his wife Heather, co-founded Tourissimo, one of the top adventure travel companies in Italy. With years of expertise designing cycling and adventure tours across all 20 regions of Italy, Beppe and Heather have the inside scoop on the most authentic and unforgettable experiences Italy has to offer.So grab your espresso (or a glass of vino Italiano), and let's explore Italy region by region!Northern Italy: Adventure, Culture, and Alpine BeautyLombardy (Lombardia)Running along the Swiss border, Lombardy is Italy's largest and wealthiest region—a land of striking contrasts and cultural riches. Home to nearly 10 million people, Lombardy contains 12 of Italy's largest cities: Milan, Bergamo, Brescia, Como, Mantua, Pavia, Cremona, Lecco, Lodi, Monza, Sondrio, and Varese. The region blends modern sophistication with old-world charm, from the fashion capital and bustling metropolis of Milan to the serene, postcard-perfect landscapes of Lake Como.Lombardy is dotted with some of Italy's most beloved lakes, including Lake Maggiore, Lake Como, Lake Garda, Lake Iseo, Lake Idro, and many more. Picturesque villages like Bellagio offer sun-drenched escapes along Lake Como's shores, while the medieval towns of Bergamo and Mantova enchant visitors with cobblestone streets, sweeping views, and centuries of history.Culinary lovers will be spoiled for choice with Lombardy's 60 Michelin-starred restaurants—3 with three stars, 6 with two stars, and 51 with one star. Be sure to savor the region's iconic Risotto alla Milanese, a creamy saffron-infused dish that's a local staple. Wine enthusiasts won't want to miss a glass of Franciacorta, Italy's sparkling answer to Champagne.November is a wonderful time to visit, with cooler temperatures and fewer tourists. It's also the perfect season to explore Lombardy's slice of the Alps, where charming mountain towns await nestled among the peaks. For an unforgettable adventure, consider attending the 2025 Winter Olympics, which will be held in Milan-Cortina d'Ampezzo!Tourissimo Tip– If you are flying into Milan, select the correct airport because Milan has two airports! For info, check out the following Tourissimo blog: https://www.tourissimo.travel/blog/avoid-this-common-travel-mistake-know-milans-two-airportsVenetoVeneto, the birthplace of Prosecco, Polenta, and the iconic Spritz, is a region rich in charm, culture, and culinary delights. Stretching from the Italian Riviera to the Venetian Pre-Alps and the stunning Dolomites, Veneto is home to both natural beauty and historic towns. Its capital, the enchanting floating city of Venice, is world-famous for its canals, gondolas, labyrinthine streets, and undeniable romance.Each of Venice's islands offers something special: admire the colorful houses of Burano, renowned for its lace-making traditions; visit Murano, celebrated for its centuries-old glassblowing artistry; and soak up the peaceful atmosphere of Torcello. Exploring these islands by vaporetto (water bus) offers a quieter, more authentic glimpse into Venetian life. Tourissimo Tip–For a few more suggestions, check out Tourissimo's blog on the Venetian Lagoon: https://www.tourissimo.travel/blog/our-favorite-destinations-in-the-venetian-lagoonBeyond Venice, Veneto boasts a treasure trove of picturesque towns. Verona, Padua, Vicenza, and Asolo each offer their own distinct history and beauty. Visit Castelfranco Veneto for a charming escape or head to Bardolino to enjoy a boat ride on Italy's largest lake, Lago di Garda. Stroll the waterfront in Castelletto sul Garda or circle the freshwater moat of Cittadella, a red-brick medieval town full of character.In the countryside, the hills of Prosecco promise stunning vineyard views, while the medieval town of Montagnana offers a taste of the past. Nature lovers can visit the volcanic Euganean Hills in Este, and cheese lovers shouldn't miss the small town of Asiago, home to one of Italy's most famous cheeses.Veneto's culinary scene shines with 34 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 29 with one star. Indulge in local specialties like Bigoli in Salsa, a hearty Venetian pasta with anchovy sauce, and toast with a glass of Prosecco, Grappa, or the regional favorite, the Select Spritz. And don't forget—Venetians love to celebrate, so let loose and join the party!Tourissimo Tips–Another fun suggestion is Veneto Marostica, the City of Chess, where they do a living chess match with hundreds of people dressed in medieval costumes every two years: https://www.tourissimo.travel/blog/marostica-the-city-of-chessPiedmont (Piemonte)Nestled at the foot of the Alps and bordered on three sides by the Mediterranean Sea, Piedmont is one of Italy's most underrated gems. With a diverse landscape that offers adventure and beauty year-round, this region is perfect for both winter skiing and summer hiking and biking, thanks to its stunning Alpine scenery.But Piedmont isn't just about breathtaking views—it's steeped in rich history and cultural significance. As the first capital of Italy, it boasts grand palaces, remarkable art, and sacred relics like the famed Shroud of Turin. The capital city of Turin is a vibrant hub, home to Europe's largest outdoor food market and the monthly Gran Balon flea market, a haven for vintage and antique lovers.Venture beyond the city and you'll discover a region bursting with charm and flavor. Tour the Langhe Hills, a paradise for vineyard visits, and sample Bagna Cauda, a warm anchovy and garlic dip beloved by locals. Wander the lakeside town of Stresa on Lake Maggiore, or stroll the cobbled streets of Neive, where views of rolling hills and storybook cottages create an unforgettable setting. In Asti, you can witness the September medieval horse races and visit the majestic Cattedrale di Santa Maria Assunta e San Gottardo. For a true fairy-tale escape, head to Macugnaga in the valley of Monte Rosa, a perfect base for both skiing and hiking. And just outside of Turin lies the hidden gem of Lake Orta, a peaceful retreat away from the crowds.Piedmont's culinary scene is just as spectacular. With 35 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 30 with one star—the region is a paradise for food lovers. Dine in Alba during white truffle season (September to January), and savor iconic regional dishes like Agnolotti del Plin and Coniglio Arrosto. Wine enthusiasts will be in heaven here—Piedmont is the land of Barolo, the "king of wines," and Barbaresco, two of Italy's most prestigious reds.Tourissimo Tips:Piedmont is home to the Slow Food movement: https://www.tourissimo.travel/blog/why-piedmont-is-renowned-for-its-slow-foodTourissimo Tip–Check out this blog for a guide to a day of eating in Turin: https://www.tourissimo.travel/blog/a-day-of-eating-in-turinTourissimo Tip–One of the Best Meals of Your Life will be at the Piazza Duomo in Alba!Emilia-RomagnaLocated in central Italy along the Adriatic coast, Emilia-Romagna is a vibrant and diverse region known for its perfect blend of “slow food” and “fast cars.” This area is considered both the culinary and automotive capital of Italy, offering rich traditions, warm hospitality, and unforgettable experiences.Food lovers will be in heaven here. Emilia-Romagna is the birthplace of iconic Italian delicacies such as Mortadella, Tortellini in Brodo, Parmigiano-Reggiano, Prosciutto di Parma, traditional Balsamic Vinegar, Lambrusco, and egg-based fresh pastas like lasagna, tortellini, and tagliatelle. A visit to Parma lets you savor authentic Parmigiano-Reggiano and world-class Prosciutto, as well as enjoy the elegant Teatro Regio opera house.The region also has a need for speed—it's home to legendary automotive brands like Ferrari, Lamborghini, and Maserati. For car enthusiasts, the Ferrari Museum in Modena is a must-see. Emilia-Romagna even has a dedicated cycling tourism office, and in summer 2023, it played host to several stages of the Tour de France, which began in nearby Florence.Beyond the food and cars, Emilia-Romagna offers a range of enchanting destinations. The capital city of Bologna is known for its Piazza Maggiore, the Two Towers, and the scenic Santuario Madonna di San Luca. In Ravenna, marvel at the dazzling, colorful mosaics and the historic San Vitale Basilica. Along the coast, vibrant seaside resorts like Cervia, Cesenatico, and Rimini create a lively, carnival-like party atmosphere from late May through September. For a more peaceful experience, explore the medieval gem of Brisighella, a lesser-known treasure full of charm.When it comes to fine dining, Emilia-Romagna doesn't disappoint. The region boasts 24 Michelin-starred restaurants, including one three-star, three two-star, and twenty one-star establishments. Visitors are often struck by the warmth and generosity of the locals—some of the most hospitable people in Italy—who express their love through exceptional food and outstanding service.Tourissimo Tips:Did you know that there is a whole other country within Emilia Romagna? https://www.tourissimo.travel/blog/san-marino-the-other-small-country-within-italyTourissimo Tip–Pietra di Bismantova was an inspiration for Dante: https://www.tourissimo.travel/blog/pietra-di-bismantova-the-inspiration-for-dantes-purgatoryTourissimo Tip–You can cross the Rubicon: https://www.tourissimo.travel/blog/crossing-the-rubiconTrentino-South TyrolNestled along Italy's northern border with Switzerland, Trentino–South Tyrol is a stunning mountainous region that blends Italian and Austrian influences, making it a top destination for nature lovers and outdoor enthusiasts. With its striking Alpine scenery, exceptional cuisine, and rich cultural duality, this region offers the best of both worlds.The South Tyrol capital, Bolzano, is renowned for having the highest quality of life in Italy, combining the clean, efficient infrastructure often associated with Germany with the flavorful food and spirited lifestyle of Italian culture.Outdoor adventurers will be captivated by the Dolomites, with their dramatic limestone peaks—ideal for hiking, skiing, and breathtaking vistas. Don't miss the Alpe di Siusi, Europe's largest Alpine meadow, which is especially stunning in spring and summer. Explore shimmering Lake Garda and uncover the region's medieval past through spectacular castles like Schloss Tirol, Castel Roncolo, and Castel d'Appiano.Tourissimo Tip–An off-the-beaten-path outdoor paradise can be found in the Alps of Trentino. Check out the Val di Sole. This is one of the areas that Beppe and Heather regularly go to on their personal vacations in Italy: https://www.tourissimo.travel/blog/the-wild-dolomitesThe culinary offerings here reflect the region's unique blend of cultures. Traditional dishes range from Bratwurst and Goulash to Italian-style pastas with hearty meats like deer. Foodies should try Speck, a savory smoked ham, perfectly paired with a glass of Gewürztraminer, a fragrant white wine native to the area. The region also produces excellent white wines and lighter reds that pair beautifully with its alpine cuisine.When it comes to fine dining, Trentino–South Tyrol excels with 33 Michelin-starred restaurants, including three three-star, five two-star, and twenty-five one-star establishments, making it one of Italy's most impressive gourmet regions.LiguriaLocated along Italy's rugged northwestern coastline, Liguria—also known as the Italian Riviera—boasts dramatic cliffs, colorful seaside villages, and incredible culinary traditions. The region is best known for the five picturesque villages of Cinque Terre, as well as the glamorous resort towns of Portofino and Santa Margherita Ligure.Tourissimo Tip– If you visit the Cinque Terre, don't forget to look up, and hike up away from the crowds to see the heroic vineyards: https://www.tourissimo.travel/blog/the-heroic-winemaking-of-the-cinque-terreBecause of the narrow, winding roads with steep drop-offs, many travelers prefer to explore the region via the local train or by public or private boat. If you're planning to hike the famous trails, be aware that entrance permits are now required due to landslides and overtourism.In the regional capital of Genoa, dive into maritime history, visit the iconic San Lorenzo Cathedral, and wander the city's old port area. Just outside Genoa, discover the secluded San Fruttuoso Abbey, accessible only by boat or footpath. In Vernazza, one of the Cinque Terre towns, visit the Doria Castle and the beautiful Santa Margherita Church.Liguria is also a celebrity hotspot, and its cuisine is just as impressive as its scenery. Known as the birthplace of pesto, the region is famous for Pesto alla Genovese, made with a special local basil. Be sure to try the region's olive oil, garlic, cheeses, and exceptional seafood, especially the anchovies. Other regional specialties include Focaccia di Recco, a cheese-filled flatbread, and lighter olive oils that perfectly complement Ligurian dishes.For fine dining, Liguria is home to seven Michelin-starred restaurants, all with one star, offering refined cuisine rooted in the region's coastal and agricultural traditions.Friuli-Venezia Giulia (Friuli)Tucked between Veneto, Austria, and Slovenia, Friuli-Venezia Giulia is a lesser-known gem that offers a unique blend of Alpine landscapes, rich cultural heritage, and coastal charm. The region features part of the Dolomites, ideal for hiking, skiing, and capturing breathtaking scenery.The capital, Trieste, is a refined port city with a fascinating blend of Italian, Austro-Hungarian, and Slavic influences. Don't miss the Miramare Castle, perched over the sea with stunning views. In Cividale del Friuli, stroll through cobbled streets and sample Frico, a savory, crispy dish made of cheese and potatoes, best enjoyed with a glass of Schioppettino, a bold red wine native to the region.For outdoor adventures and relaxation, spend a beach day at Lignano Sabbiadoro, camp in Sistiana, bike the trails around Grado, or explore the ancient Roman ruins in Aquileia, a UNESCO World Heritage Site. Be sure to visit the enormous Grotta Gigante (Giant Cave), stroll through Unity of Italy Square, and tour the Revoltella Museum for modern art.Friuli-Venezia Giulia is also home to seven Michelin-starred restaurants, including two two-star establishments and five one-star venues, reflecting the region's quiet but impressive culinary scene.Tourissimo Tip– A hotel that Heather and Beppe love in Cormons is La Subida. It's a unique, high-end, and rustic property nestled in nature that boasts a 1-Michelin star restaurant: https://www.tourissimo.travel/blog/hotels-we-love-la-subidaAosta ValleyNestled in the northwestern tip of Italy, where it borders Switzerland and France, the Aosta Valley is Italy's smallest and highest region—a true mountain paradise. This alpine jewel is renowned for its dramatic snowcapped peaks, storybook castles, and a unique blend of French and Italian culture, as both languages are spoken here.The region is home to Mont Blanc (Monte Bianco), Europe's highest peak, which straddles the borders of Italy, France, and Switzerland. While the summit lies on the French side, visitors on the Italian side can experience the Skyway Monte Bianco, a breathtaking cable car ride offering panoramic views of the Alps.Key landmarks include the striking Matterhorn, the impressive Fénis and Savoy Castles, and the Bard Fortress, one of the largest and most remarkable fortifications in the Alps. After a day in the mountains, relax in one of the region's thermal spas, and indulge in Fonduta, a rich, velvety cheese fondue perfect for chilly alpine evenings.Wine lovers should sample the region's distinctive red mountain wines, especially Enfer d'Arvier, known for its bold flavor and high-altitude character.Tourissimo Tip–A fun tradition is the Friendship Cup, a communal cup of coffee: https://www.tourissimo.travel/blog/the-friendship-cup-of-valle-daostaCentral Italy: History, Art, and Rolling HillsTuscany (Toscana)Tuscany, the heart of the Renaissance, is a captivating region of rolling hills, cypress-lined roads, vineyards, and timeless art and architecture. Located just below Italy's northern regions, it's a haven for art lovers, history buffs, and food and wine enthusiasts alike. From Chianti to Brunello di Montalcino, the region offers a wide variety of world-class wines.The regional capital, Florence, is one of Italy's most walkable and safe major cities, making it ideal for solo travelers. Admire its architectural wonders while sipping on Chianti Classico and indulging in a local favorite—Bistecca alla Fiorentina. Must-see landmarks in Florence include the Cathedral of Santa Maria del Fiore (Duomo), Ponte Vecchio, Palazzo Vecchio, the Uffizi Gallery, and the Galleria dell'Accademia, home to Michelangelo's David. For iconic views, head to Piazzale Michelangelo.Beyond Florence, explore the historic cities of Siena, Lucca, and San Gimignano, each offering its own charm. Don't miss the Leaning Tower of Pisa or the Siena Cathedral, and spend time in the picturesque public squares like Piazza del Campo, Piazza della Signoria, and Piazza del Duomo.For off-the-beaten-path adventures, discover medieval hilltop villages such as Sorano, or head to the Maremma coast for scenic beaches and bold wines. Tuscany also shines in its culinary excellence, boasting 41 Michelin-starred restaurants—including 1 three-star, 5 two-star, and 35 one-star establishments.Tourissimo Tip–3 places in Tuscany you didn't know existed: https://www.tourissimo.travel/blog/three-places-in-tuscany-you-did-not-know-existedUmbriaUmbria, often called the "Green Heart of Italy," is the country's only completely landlocked region, nestled between Tuscany, Lazio, and Le Marche. Though it lacks large cities, Umbria more than makes up for it with breathtaking natural beauty, medieval towns, and a rich culinary tradition.One of Umbria's most impressive sights is the Cascata delle Marmore (Marmore Falls)—the second tallest waterfall in Europe. Nature lovers and photographers alike will be amazed by its dramatic 165-meter drop. The region is also home to Assisi, the birthplace of St. Francis, one of Italy's most revered saints, and a major pilgrimage destination.Food lovers will delight in Umbria's hearty, earthy cuisine, featuring lentils, mushroom-based dishes, cured meats, and the prized black truffle (Tartufo Nero di Norcia). Pair these specialties with a glass of Sagrantino di Montefalco, a robust red wine unique to the region.Umbria's culinary excellence is further reflected in its four Michelin-starred restaurants: Casa Vissani, Vespasia, Ada, and Elementi. Each holds one Michelin star, offering refined takes on the region's rustic flavors.Tourissimo Tip–Norcia is definitely one of Italy's culinary gems: https://www.tourissimo.travel/blog/norcia-one-of-italys-culinary-gemsMarcheLocated in central Italy on the Adriatic side, Marche is a beautiful region with a population of 1 million people, known for its charming towns, rich history, and welcoming, hardworking culture. The region offers stunning destinations like Urbino and Ancona, along with pristine beaches such as Spiaggia della Due Sorelle, Parco Naturale Monte San Bartolo, Mezzavalle, and the Riviera del Conero, not to mention many picturesque nature reserves.Must-see landmarks include Castello di Gradara, Palazzo Ducale di Urbino, the Sanctuary of the Holy House of Loreto, Cattedrale di San Ciriaco, Tempio del Valadier, and the breathtaking underground Frasassi Caves. Marche's favorite cities and nearby towns also include Gubbio, Assisi, Perugia, Orvieto, and Cascia.For those drawn to religious history, highlights include the Papal Basilica of Saint Francis, the Sacred Convent of Saint Francis, Basilica di Santa Maria degli Angeli, and Basilica di Santa Chiara in Assisi, as well as the Basilica of Santa Rita da Cascia. History lovers should visit Rocca Paolina, Piazza IV Novembre, Fontana Maggiore, Piazza del Comune, and Grotta di Monte Cucco, while museums like Narni Sotterranea, the National Gallery, and Nobile Collegio del Cambio offer rich cultural experiences.This region is famous for its culinary tradition, especially its mastery of seafood, and is home to seven Michelin-starred restaurants — including Uliassi in Senigallia, proudly holding three Michelin stars, along with one two-star and five one-star establishments. No visit would be complete without tasting Olive all'Ascolana, fried stuffed olives that perfectly capture Marche's local flavor. All of this, combined with the region's natural beauty and warm, fun, and friendly locals, makes Marche a truly unforgettable destination in the heart of Italy.Tourissimo Tip–Ascoli Piceno, the town where the Ascoli olive is from, is beautiful, especially at night when it appears to glow: https://www.tourissimo.travel/blog/ascoli-piceno-the-italian-town-that-glows-at-nightLazioLazio, one of Italy's central regions, though often considered a southern region by Italians, is a place rich with history, iconic landmarks, and hidden gems. At its heart is the capital city of Rome, a destination overflowing with opportunities for exploration. Essential sites include the Colosseum, Trevi Fountain, Pantheon, Roman Forum, Spanish Steps, St. Peter's Basilica, the Sistine Chapel, and countless other remarkable attractions. No visit to Rome is complete without savoring its famous dishes, including Cacio e Pepe — a creamy cheese and pepper pasta — along with local favorites like Spaghetti alla Gricia, Pasta all'Amatriciana, and Pasta Carbonara, best enjoyed with a glass of crisp Frascati wine while taking in views of the Colosseum. Lazio as a whole has 107 two-star Michelin restaurants and 105 one-star restaurants. If you find yourself in the Trastevere neighborhood, there are many wonderful popular restaurants, including La Scaletta and Le Mani in Pasta.Another must-see is Vatican City, home to the Vatican and its world-renowned religious and artistic treasures. In December 2025, Rome will host the Jubilee, or Holy Year — a significant Catholic Church event focused on forgiveness, reconciliation, and spiritual renewal, held only once every 25 years and drawing pilgrims from across the globe.Beyond Rome, Lazio offers a beautiful coastline and peaceful countryside, perfect for travelers seeking quieter escapes. Among its hidden gems is Ostia Antica, an ancient Roman city that once served as the bustling port of Rome, located at the mouth of the Tiber River. With its blend of legendary landmarks, culinary traditions, religious significance, and off-the-beaten-path treasures, Lazio is a captivating region waiting to be explored.Tourissimo Tip–There's a wonderful project underway to create a cycle path around the perimeter of Rome: https://www.tourissimo.travel/blog/cycling-in-rome-grab-a-bike-and-bike-the-grabAbruzzoAbruzzo, known as Italy's green region, lies in the central-eastern part of the country and boasts a stunning combination of mountains, coastline, and unspoiled nature. Along the beautiful Trabocchi Coast, visitors can admire the historic trabocchi — ingenious wooden fishing structures built by fishermen centuries ago to safely fish the Adriatic waters, many of which have now been converted into charming seaside restaurants where you can dine on fresh seafood while suspended above the waves with sunsets as your backdrop. When it comes to dining, Abruzzo currently boasts four Michelin-starred restaurants; there are three 1-star restaurants and one 3-star restaurant. Food lovers shouldn't miss Arrosticini, the region's famous grilled lamb skewers, or a glass of bold Montepulciano d'Abruzzo red wine. Outdoor enthusiasts have countless opportunities for adventure, from swimming at the Stiffe Caves and strolling the Ponte del Mare to relaxing on the beaches of Riserva Naturale Guidata Punta Aderci and hiking to the iconic Rocca Calascio. Lakeside escapes await at Lago di Scanno and Lago di Barrea, while the towering Gran Sasso d'Italia and the expansive Parco Nazionale d'Abruzzo, and Lazio e Molise offer breathtaking scenery and pristine trails. The region is home to many national parks — Abruzzo, Lazio, Molise National Park, Gran Sasso and Laga Mountains National Park, and Maiella National Park — perfect for hiking, biking, trail running, and spotting the highest peaks of the Apennine Mountain Range. Cyclists can enjoy the Bike to Coast cycle path, a 131 km (81.4 mile) route running along the Adriatic coast from Pescara to Vasto. History and architecture lovers will appreciate sites like Basilica di Santa Maria di Collemaggio, Centro Storico di Sulmona, Santo Stefano di Sessanio, Abbey of San Giovanni in Venere, and the Medieval Village of Pacentro. For a uniquely tranquil experience, visit the enchanting Gardens of Ninfa. Abruzzo is also a fabulous winter skiing destination and keeps traditions alive with events like Transumanza, the seasonal migration of livestock, primarily sheep, between the high-altitude pastures of the region. With its mountain majesty, historic villages, flavorful cuisine, and coastal charm, Abruzzo offers something unforgettable for every traveler.Tourissimo Tips:More info on the trabocchi coast: https://www.tourissimo.travel/blog/abruzzos-trabocchi-coastAbruzzo Bike to Coast is a beautiful bike path along the coast: https://www.tourissimo.travel/blog/cycling-along-abruzzos-coastMoliseOne of Italy's most untouched and lesser-known regions, Molise is famously nicknamed “the region that doesn't exist,” though it's rich in history, traditions, and natural beauty. This quiet region offers a mix of beaches and mountains, including part of the National Park of Abruzzo within the Apennines mountain range, filled with abundant wildlife, hiking trails, and winter ski opportunities. Tourissimo Tip–The Region That Doesn't Exist: https://www.tourissimo.travel/blog/the-italian-region-that-doesnt-existThe capital city, Campobasso, is home to notable sites like Monforte Castle and several Romanesque churches, while the charming coastal town of Termoli draws visitors for its beaches, trabucchi (historic fishing huts now serving fresh seafood), and local specialties like brodetto, a traditional seafood stew. Along the Molise coast in Termoli, dining at a trabucchi offers fresh catches with a side of Adriatic views. History buffs should visit the Samnite ruins in the Pietrabbondante archaeological area, the well-preserved Saepinum Archaeological Area, and landmarks like Lago di Castel San Vincenzo, the Cathedral of Saint Mary of the Purification, Monforte Castle, and the Basilica of Saint Mary of Sorrow. A must-see is the Marinelli Bell Foundry, founded in 1339. It's the oldest continuously operating bell foundry in the world, Italy's oldest family business, and the official provider of bells to the Vatican. Food lovers can sample Cavatelli, a local pasta specialty, paired with Tintilia, a rare red wine unique to Molise. The region is also home to seven one-star Michelin restaurants and several local food tours that showcase its rustic culinary traditions. While Molise's quiet charm and untouched landscapes make it a special destination, visitors should note that English is not widely spoken, making it a truly authentic Italian experience for those eager to explore one of the country's hidden gems.Southern Italy: Sun, Sea, and Ancient WondersCampania The birthplace of Neapolitan pizza, the Mediterranean Diet, and Mozzarella di Bufala, Campania is one of Italy's most vibrant and culturally rich regions. Home to the bustling regional capital Naples (Napoli), it boasts some of the country's most iconic destinations, including Pompeii, the stunning Amalfi Coast, and the tranquil Cilento Coast.Along the sparkling, deep-blue waters of the Golfo di Napoli, you'll find must-visit coastal towns like Positano, Amalfi, and Ravello, as well as the famous islands of Ischia, Capri, and the colorful Procida. Visitors can hike the breathtaking Path of the Gods, explore the hauntingly preserved ruins of Archaeological Pompeii, forever shadowed by the gray cone of Mt. Vesuvius, and savor the region's culinary gems like ultra-fresh seafood and crisp Falanghina wine.History and culture lovers shouldn't miss Sansevero Chapel Museum, San Carlo Theatre, the Catacombs of San Gennaro, and the lush Villa Cimbrone Gardens. Campania also impresses with its historic castles, including the Royal Palace of Caserta, Ovo Castle, and Castello Aragonese d'Ischia. Wine enthusiasts should head to the province of Avellino, known for producing some of the best wines in southern Italy.Tourissimo Tip–Wine is also grown inland on the Amalfi Coast, and there are some vines that are 250 years old (pre-phylloxera): https://www.tourissimo.travel/blog/old-vines-on-the-amalfi-coastNature lovers will be drawn to the Cilento, Vallo di Diano, and Alburni National Park, a UNESCO World Heritage Site celebrated for its biodiversity, dramatic landscapes, and cultural heritage, featuring ancient ruins like Paestum and Velia, the majestic Padula Charterhouse, and idyllic coastal villages.Campania is also a paradise for food lovers, home to 51 Michelin-starred restaurants, including one three-star, eight two-star, and forty-two one-star establishments. From world-famous landmarks to hidden treasures, Campania offers an irresistible blend of history, nature, food, and coastal charm.CalabriaWith its rugged coastlines, dramatic landscapes, and hidden treasures, Calabria is a must-visit region in southern Italy. Known for its bold flavors and rich culinary traditions, visitors should sample 'Nduja, a spicy, spreadable sausage paste, and the region's famous Calabrian chiles. The local cuisine embraces cucina povera, a tradition of simple, hearty dishes featuring handmade pasta made with just flour and water. Calabria offers a growing fine dining scene with six one-star Michelin restaurants. For nature lovers, Calabria is home to three stunning national parks — Sila, Aspromonte, and Pollino — ideal for hiking, wildlife spotting, and immersing in untouched landscapes. Along the coast, Capo Vaticano stands out as one of the world's most beautiful beaches, offering breathtaking views and crystal-clear waters. History buffs and castle enthusiasts can explore impressive fortresses like Castello Ruffo di Scilla, Castello Murat, Castello di Le Castella, and Castello Aragonese. Don't miss charming towns and villages such as Tropea, famous for its clifftop views and beaches, as well as Scilla, Pentedattilo, and Le Castella. With its authentic culture, stunning coastlines, flavorful cuisine, and rich history, Calabria remains one of Italy's most captivating yet underrated regions.Tourissimo Tip–Way off the beaten path, lies a  unique museum in Mammola, Calabria https://calabriastraordinaria.it/en/news/visit-to-musaba-the-sistine-chapel-of-calabriaPugliaKnown as the Maldives of Italy, Puglia is a sun-drenched region celebrated for its whitewashed hill towns, ancient olive groves, and miles of stunning coastline. With a dry Mediterranean climate and scenery that often feels more Greek than Italian, Puglia is famed for its beaches in Salento, crystal-clear waters, and charming seaside towns. One of its most iconic sights is the fairytale-like trulli houses of Alberobello, a UNESCO World Heritage Site. This region is also a food lover's paradise, offering specialties like Orecchiette pasta with turnip greens, the classic Fave e Cicoria (fava bean purée with wild chicory), and fresh seafood paired with crisp vegetables. Wine lovers can savor Primitivo, a bold local red. For fine dining, the region boasts nine one-star Michelin restaurants, blending rustic flavors with refined culinary creativity.Puglia is dotted with unique cities and towns worth exploring, including Locorotondo, Otranto, Lecce, Monopoli, Ostuni, Gallipoli, Bari, Alberobello, and Polignano a Mare. Nature and history enthusiasts will enjoy visiting extraordinary sites like the Grotte di Castellana, the dramatic Cave of Poetry, the ancient Basilica San Nicola, and the scenic Gargano Peninsula. With its thousand-year-old olive trees, Puglia is the largest olive oil producer in the world, known for its strong, spicy oils. The locals here are famously warm and welcoming, going out of their way to make visitors feel at home.Puglia's blend of natural beauty, rich tradition, and heartfelt hospitality makes it one of Italy's most captivating and underrated destinations.Tourissimo Tip–Here are some of the gems of Puglia: https://www.tourissimo.travel/blog/some-of-the-gems-of-pugliaBasilicataBasilicata, a remote yet captivating region with a population of just 500,000, offers a wealth of unique experiences despite its secluded location. Among its most intriguing destinations are the ghost town of Craco and the ancient cave city of Matera, both steeped in history and cinematic charm. Other towns worth visiting include Maratea and Palombaroa, each offering its own cultural and scenic appeal.Tourissimo Tip–Matera is magical! https://www.tourissimo.travel/blog/destination-highlight-matera-the-city-of-stonesThe region is rich in historical and religious landmarks, such as the Crypt of Original Sin with its remarkable frescoes, and the medieval Melfi Castle. Don't miss the towering Statue of Christ the Redeemer in Maratea, a striking monument that overlooks the Tyrrhenian coast.For a taste of local flavor, try Peperoni Cruschi—crispy, sun-dried peppers that are a beloved regional delicacy. Basilicata is also known for its exceptional wines, especially the bold, full-bodied reds of Aglianico del Vulture DOC, made primarily from the Aglianico grape. White wine lovers will appreciate the region's Greco di Tufo and Fiano varietals as well. Basilicata also has a total of 14 one-star Michelin restaurants. Adventurers can experience an adrenaline rush on The Angel's Flight, a giant zip line that offers stunning views and a thrilling ride through the Lucanian landscape.SicilySicily, the largest island in the Mediterranean Sea, is a world of its own, offering a diverse landscape of coastlines, mountains, and magical towns such as Cefalù, Palermo, Taormina, Catania, Noto, Agrigento, and Syracuse. Palermo serves as the cultural and diplomatic capital of the region, while Catania stands as its business hub.A volcanic island and UNESCO World Heritage Site, Sicily boasts a rich collection of cultural and natural treasures. Highlights include the awe-inspiring Valley of the Temples, the active volcano Mount Etna, the stunning Duomo di Cefalù, and the picturesque islands of Stromboli, Bella, and Ortigia. The region is also home to the renowned Baroque Triangle in the Val di Noto region of southeastern Sicily, where the eight towns of Caltagirone, Militello Val di Catania, Catania, Modica, Noto, Palazzolo Acreide, Ragusa, and Scicli have been recognized by UNESCO for their outstanding examples of late Baroque architecture.Sicily's culinary scene is just as impressive. Indulge in traditional Sicilian cannoli, filled with sheep's milk ricotta cheese and always stuffed fresh to order. Take a street food tour to savor local favorites like arancini, and don't miss sipping on a glass of Nero d'Avola, one of Sicily's most famous wines. The region is also internationally celebrated for its top-tier agriculture and winemaking.For a taste of authentic Italian charm beyond the tourist trail, explore the towns featured in I Borghi Più Belli d'Italia—Italy's list of its most beautiful hidden gems. Tourissimo Tip–This is a great tip for all 20 regions of Italy. Find out more here: https://www.tourissimo.travel/blog/the-most-beautiful-small-towns-in-italyFood lovers will be delighted to know that Sicily is also home to 23 Michelin-starred restaurants, including three two-star establishments and twenty with one star.Tourissimo Tip–If you visit Corleone, you should definitely learn about the legacy of the Mafia. We in North America tend to have a romanticized view of the mafia, but for the locals, the history is more brutal. See some photos and learn more here: https://www.tourissimo.travel/blog/letizia-battaglia-groundbreaking-photojournalist-who-fearlessly-documented-the-mafia-in-her-native-sicilySardiniaSardinia, the second-largest island in the Mediterranean after Sicily, is a rugged, rural paradise known for its natural beauty, deep-rooted traditions, and ancient history. The island is home to features like the Apennine Coast, the Adriatic Coast, and the Apennine Mountains. Most of Sardinia's population lives in the capital region of Cagliari, but much of the island remains untouched, offering visitors a glimpse into authentic Italian island life.One of Sardinia's most fascinating distinctions is that the Barbagia region is recognized as a Blue Zone—an area with an unusually high number of centenarians. This longevity is attributed to the region's healthy diet, active lifestyle, and strong sense of community. For outdoor enthusiasts, inland Sardinia offers some of the best biking and hiking experiences in all of Italy.Tourissimo Tip–What is a Blue Zone? https://www.tourissimo.travel/blog/blue-zoneThe island's coastlines are just as enticing. Costa Smeralda is often described as paradise on earth, with stunning beaches like Spiaggia di Tuerredda, Cala Goloritzé, and Spiaggia di Porto Giunco perfect for sunbathing and swimming. Don't miss the La Maddalena Archipelago National Park (Parco Nazionale dell'Arcipelago di La Maddalena), a protected area with crystal-clear waters and pristine landscapes.Charming towns such as Alghero, Bosa, and Cagliari add to the island's appeal. Many of Sardinia's towns are nestled in the mountains located in the island's center, offering a peaceful and scenic escape.Cultural and historical attractions abound. Must-see sites include the Nora Archaeological Park, Bastione di Saint Remy, Parco Archeologico Naturalistico di Santa Cristina, and the Museo Archeologico Nazionale di Cagliari. For an unforgettable natural wonder, venture into the Frecce delle grotte srl and Neptune's Grotto, stunning sea caves accessible by boat or stairs carved into cliffs.Sardinia is also home to a unique ancient civilization. Scattered across the island are over 7,000 nuraghe—megalithic stone structures built during the Nuragic Age (c. 1900–730 BC). These mysterious, tower-like buildings are the island's most iconic symbol, and some scholars believe there were once over 10,000 nuraghe structures in total.Religious architecture also impresses, with highlights like the Cattedrale di Santa Maria Assunta e Santa Cecilia, the Church of the Holy Trinity of Saccargia, and the Basilica di San Simplicio showcasing Sardinia's spiritual and artistic heritage.Sardinian cuisine reflects its mountainous geography. Surprisingly, for an island, the diet leans more toward land-based ingredients than seafood. Signature dishes include Porceddu (roast pig), Fregola (a traditional Sardinian pasta), and the adventurous Casu marzu—a sheep's milk cheese intentionally infested with live maggots and considered a local delicacy. Sardinia also holds 16 one-star Michelin restaurants.To accompany these flavors, try a glass of Cannonau red wine, known for its high polyphenol content and potential health benefits, or the refreshing Vermentino white wine, perfect for warm Mediterranean days.Tourissimo Tip–Magic Trick or Pasta Making? https://www.tourissimo.travel/blog/magic-trick-or-pasta-making From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio!From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio! 

Jabot vs. Victor Newman; Audra mists Nate… with sexiness!; The return of Abby; Lily asks Damian to help her find out about Dumas; That cool scene with Amy and Traci; and A meeting of the Martin Laurent survivors club. Hey everybody! Why not pick up a bonus Y&R Chat episode at: http://www.GenoaCitySoap.com I love hearing […]

Welcome to the final day of this voyage, Catholic Pilgrims. I feel like this trip was quick. We've been all over the place with Mother Cabrini. We started in Genoa, sailed through the Mediterranean, steamed by the Balearic Islands, Gibraltar, Morocco, the Azores, and now we will read about Mother and her Sisters docking at Hoboken.  I went to look Hoboken up. It's in New Jersey, which I didn't know. It's a terminal that has been used since colonial times. Today, more than 50,000 people come through that terminal daily, which is incredible. There's lots of things there now, it's not just a dock. Since this is the end of a voyage, I will give my short reflection. Let's go ahead and open our books to page 105. Hoboken Docks: https://en.wikipedia.org/wiki/Hoboken_Terminal

Welcome, Catholic Pilgrims. We are nearing the end of this journey. I told my daughter the other night that Mother Cabrini has really made me want to travel with this voyage. There's just so many places to see and so little time.  It's funny, as I was reading through today's letter, I realized just how far I've come in understanding our Catholic faith. Had you given me today's letter to read when I was a Protestant, it would have sailed over my head. Words and phrases like, Holy Charity, Our Lady's Mantle, Immaculate Mother, God's attributes, were utterly foreign to me. I had never heard those topics spoken about once in the first 30 years of my life.  Now, after years of study and having been a Catholic for a little over 15 years, I have been gifted with so much richness and depth to the spiritual life. It's something I'm eternally grateful for AND there's still so much to learn! So, let's learn from Mother Cabrini by turning to page 102.

Martin reveals himself; Traci is devastated; Sharon and Phyllis have their say; Summer and Chance call it quits; and Audra agrees to sabotage Kyle and Claire in exchange for a new company! Hey everybody! Why not pick up a bonus Y&R Chat episode at: http://www.GenoaCitySoap.com I love hearing from YOU! Please feel free to comment, […]

It's time for The Truth!Today, Sam and Dougie are looking at Arsenal and in particular, a big reshuffle in the boardroom that has seen Andrea Berta succeed Edu Gaspar as their Sporting Director. Berta was formerly at Atletico Madrid, forming a (mostly) impressive team with Diego Simeone, and also previously worked at Genoa and Parma in his native Italy. We examine what his record was at Atleti in terms of overseeing signings, discuss which positions and players Arsenal may look to in the summer under his stewardship, and scrutinise how the Manager-SD relationship works at Arsenal in particular with Mikel Arteta. There's a little bit of time too to examine the role of a Sporting Director in the modern game, and look at exactly what falls under their remit, before we round things off. So, is this the appointment that helps steer Arsenal through that final step where they lift a Premier League trophy? Will he mesh with what Arteta wants and needs on the pitch? Or is this simply background shuffles that bark louder than they actually bite? Well, The Truth is somewhere in the middle... And remember, if you'd like more from the Rank Squad, including extra podcasts every Monday and Friday (including our weekly Postbox taking a look at the whole weekend of football) and access to our brilliant Discord community, then why not join us here on Patreon?