GameChangers |  CEimpact

It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration! GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music! Reference: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. PMID: 29032957. Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020 Jan;99(1):57-63. doi: 10.1007/s00277-019-03871-z. Epub 2019 Dec 6. PMID: 31811360. Visapää JP, Tillonen JS, Kaihovaara PS, et al. Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother. 2002 Jun;36(6):971-4. doi: 10.1345/aph.1A066. PMID: 12022894. Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018 May 1;75(5):566-572. doi: 10.1001/jamaneurol.2017.5144. PMID: 29482205; PMCID: PMC5885255. CPE details for GameChangers Podcast April 2021 Learning Objective: Discuss the evidence-based dosing of oral iron supplementation. 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

Alzheimer's Disease and Related Dementias are a terrible disease on individuals, caregivers, and communities. There are no cures. However, new data has come out discussing the risk factors, polypharmacy, and a potential early detection opportunity. It's time to de-prescribe and follow the money. Reference: Nicholas LH, Langa KM, Bynum JPW, Hsu JW. Financial Presentation of Alzheimer Disease and Related Dementias. JAMA Intern Med. 2021;181(2):220–227. doi:10.1001/jamainternmed.2020.6432 Maust DT, Strominger J, Kim HM, et al. Prevalence of Central Nervous System–Active Polypharmacy Among Older Adults With Dementia in the US. JAMA. 2021;325(10):952–961. doi:10.1001/jama.2021.1195 CPE details for GameChangers Podcast April 2021 Learning Objective: Discuss if adverse financial outcomes may be a risk factor for future dementia diagnosis. 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  Disclosure: Dr. Galdo is a member of the Board of Directors for the Alabama Chapter of the Alzheimer's Association. See omnystudio.com/listener for privacy information.

More and more vaccines are getting authorization in the United States to prevent COVID-19. However, sometimes a vaccine trial is not always effective. But even failure can provide new insights. Learn about the Janssen COVID-19 vaccine and what happened with the recent Hepatitis C vaccine candidate. This podcast was recorded prior to the joint CDC and FDA statement on the Johnson & Johnson/Janssen COVID-19 vaccine on April 13th. On April 13th, 2021, the CDC and FDA issued a joint statement recommending a pause on the use of the Johnson & Johnson/Janssen COVID-19 vaccine until further notice. Click here for the full statement. Reference: Page K, Melia M, Veenhuis R, et al. Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection. N Engl J Med 2021; 384:541-549. DOI: 10.1056/NEJMoa2023345 Fact Sheet for Healthcare Providers Administering Vaccine Emergency Use Authorization of the Janssen COVID-19 Vaccine to Prevent Coronavirus Disease 2019. https://www.fda.gov/media/146304/download  CPE details for GameChangers Podcast April 2021 Learning Objective: Describe the outcomes of a recently published trial on hepatitis C vaccine candidates. 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

The battle against the COVID-19 pandemic has continued for over a year. The evidence continues to update and change, and more and more people are becoming vaccinated. This episode provides a review of the newest literature including guidance on vaccinated individuals. But, remember, don't stop wearing a mask now! Reference: Interim Public Health Recommendations for Fully Vaccinated People. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/fully-vaccinated-guidance.html. CPE details for GameChangers Podcast April 2021 Learning Objective: Describe evidence-based recommendations to mitigate SARS-CoV-2 infections 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

Recently the American Gastroenterological Society updated their guidelines for treatment for a true medical emergency: gastric and esophageal bleeding. This episode reviews the guidelines and highlights the importance of several changes to management. Today's episode is sponsored by a special CEimpact FREE Law focused webinar: Make sure to save your spot for FREE LIVE LAW CE April 1st. 7PM. https://ceimpact.com/law  Reference: Henry Z, Patel K, Patton H, et al. AGA Clinical Practice Update on Management of Bleeding Gastric Varices: Expert Review. Clinical Gastroenterology and Hepatology. 2021. https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S154235652100077X?returnurl=null&referrer=null  CPE details for GameChangers Podcast March 2021 Learning Objective: Identify appropriate therapy for individuals with variceal bleeds based on the new guidelines 0107-0000-21-097-H01-P 0.25 CEU/2.5 Hrs (Knowledge) Initial Release Date: 03/02/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

Aspirgillosis is a deadly fungal infection that is a major cause of mortality in patients with impaired immune systems. The current standard of care has been voriconazole due to the favorable side effect profile compared to amphotericin. However, posaconazole may not have there adverse effects and be a reasonable course of therapy. Is voriconazole just just a phase? Today's episode is sponsored by a special CEimpact FREE Law focused webinar:  Save your spot - FREE LIVE LAW CE webinar on April 1st.  SPOTS ARE LIMITED! https://ceimpact.com/law  Reference: Maertens JA, Rahav G, Lee DG, et al. Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial. Lancet. 2021 Feb 6;397(10273):499-509. doi: 10.1016/S0140- 6736(21)00219-1. PMID: 33549194. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, Volume 63, Issue 4, 15 August 2016, Pages e1–e60, hMps://doi.org/10.1093/cid/ciw326 CPE details for GameChangers Podcast March 2021 Learning Objective: Develop appropriate treatment of aspergillosis infections based on clinical studies. 0107-0000-21-097-H01-P 0.25 CEU/2.5 Hrs (Knowledge) Initial Release Date: 03/02/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

The recently published STEP trial showed a dramatic effect on weight loss with the weekly injectable semaglutide versus placebo. Lay media picked up the headlines from this potential "GameChanger" medication for weight loss. With this one shot will patient lose themselves? Reference: Wilding J, Batterham R, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. February 10, 2021. DOI: 10.1056/NEJMoa2032183 CPE details for GameChangers Podcast March 2021 Learning Objective: Discuss the design of the STEP trial 0107-0000-21-097-H01-P 0.25 CEU/2.5 Hrs (Knowledge) Initial Release Date: 03/02/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

The endocannabinoid system is influenced by compounds found the Cannabis genus of plants and involves two compounds: cannabidiol (CBD) and tetrahydrocannabinol (THC). Federal and state regulation is changing, so the medicinal and recreatoinal use of cannabis-related prodcuts continues to increase. Although not life-threatening, some patients may experience Cannabis Hyperemesis Syndrome. Fortunately, a narrative review outlines the causes and treatment to help get out the weeds of treatment. Reference: Perisetti A, Gajendran M, Dasari C, et al. Cannabis hyperemesis syndrome: an update on the pathophysiology and management. Annals of Gastroenterology (2020) 33, 1-8. http://www.annalsgastro.gr/files/journals/1/earlyview/2020/ev-09-2020-01-AG_5230-0528.pdf  CPE details for GameChangers Podcast March 2021 Learning Objective: Describe the potential mechanisms and treatment options for Cannabis Hyperemesis Syndrome. 0107-0000-21-097-H01-P 0.25 CEU/2.5 Hrs (Knowledge) Initial Release Date: 03/02/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

The recently published (in a pre-print server) COLCORONA study, sponsored by the Montreal Heart institute and conducted in 6 countries aimed to show if using colchicine would decrease risk of hospitalization and death in outpatients with COVID-19. Will it work? How's the study design? Learn the facts. Reference: Tardif J, Bouabdallaoui N, L'Allier P, et al. Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19. Pre-Print. https://www.medrxiv.org/content/10.1101/2021.01.26.21250494v1 CPE details for GameChangers Podcast March 2021 Learning Objective: Apply the results of the CORCORONA study to patients with COVID-19 disease. 0107-0000-21-097-H01-P 0.25 CEU/2.5 Hrs (Knowledge) Initial Release Date: 03/02/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

The United States Preventative Services Task Force (USPSTF) recommendations for tobacco cessation have been recently updated. While no major changes to pharmacotherapy recommendations are in the new guidelines, the paper does emphasize that all health care providers can work with patients to help them achieve tobacco freedom. Learn how to support patients in your community. Reference: USPSTF Recommendation: https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions  CPE details for GameChangers Podcast February 2021 Learning Objective: Discuss the rates of tobacco cessation and adverse effects of current Food and Drug Administration approved therapy for tobacco cessation. 0107-0000-21-083-H01-P 0.2 CEU/2.0 Hrs (Knowledge) Initial Release Date: 02/23/21 Expiration Date: 02/23/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

The National Asthma Education and Prevention Program released the 2020 Asthma Guideline Update in December 2020. This guideline, published in JAMA, is different from the internal Global Initative for Asthma (GINA) guidelines and represents the first update since 2007. Learn about what makes these guidelines unique and how healthcare providers can maintain breaths. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! Reference: Commentary: Cloutier MM, Dixon AE, Krishnan JA, Lemanske RF, Pace W, Schatz M. Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program. JAMA. 2020;324(22):2301–2317. doi:10.1001/jama.2020.21974  Guidelines: 2020 Focused Updates to the Asthma Management Guidelines. https://www.nhlbi.nih.gov/health-topics/all-publications-and-resources/2020-focused-updates-asthma-management-guidelines  CPE details for GameChangers Podcast February 2021 Learning Objective: Describe recommended therapy based on the staging on asthma in individuals 12 years or older Guest Faculty: Kelli Cunningham, PharmD, BCPS Dr. Cunningham reports no actual or potential conflicts of interest in relation to this episode of GameChangers. 0107-0000-21-083-H01-P 0.2 CEU/2.0 Hrs (Knowledge) Initial Release Date: 02/23/21 Expiration Date: 02/23/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

Irritable bowel syndrome is a common disorder that exacts a significant toll on quality of life. For the first time, the American College of Gastroenterology has published guidelines on the diagnosis and treatment for this disorder. This episode is accredited for CPE. Subscribe at CEimpact ( https://www.ceimpact.com/pharmacist ) and claim your CE today! Reference: Lacy, Brian E. PhD, MD, FACG1; Pimentel, Mark MD, FACG2; Brenner, Darren M. MD, FACG3; Chey, William D. MD, FACG4; Keefer, Laurie A. PhD5; Long, Millie D. MDMPH, FACG (GRADE Methodologist)6; Moshiree, Baha MD, MSc, FACG7 ACG Clinical Guideline: Management of Irritable Bowel Syndrome, The American Journal of Gastroenterology: January 2021 - Volume 116 - Issue 1 - p 17-44 doi: 10.14309/ajg.0000000000001036. Accessed at https://journals.lww.com/ajg/Fulltext/2021/01000/ACG_Clinical_Guideline__Management_of_Irritable.11.aspx  Bristol stool scale (recommend tertiary references): Lewis, SJ; Heaton, KW (September 1997). "Stool form scale as a useful guide to intestinal transit time". Scand. J. Gastroenterol. 32 (9): 920–4. doi:10.3109/00365529709011203. PMID 9299672. CPE details for GameChangers Podcast February 2021 Learning Objective: Discuss appropriate treatments for irritable bowel syndrome 0107-0000-21-083-H01-P 0.2 CEU/2.0 Hrs (Knowledge) Initial Release Date: 02/23/21 Expiration Date: 02/23/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

Lyme disease is a complex infection and post infection syndrome can lead to serious outcomes, including death. A new guideline was developed for the diagnosis and treatment of this infection. Spoon! This episode is accredited for CPE. Subscribe at CEimpact ( https://www.ceimpact.com/pharmacist ) and claim your CE today! Reference: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases, November 30, 2020. https://doi.org/10.1093/cid/ciaa1215. Accessed at https://www.idsociety.org/practice-guideline/lyme-disease/  CPE details for GameChangers Podcast February 2021 Learning Objective: Discuss treatment for different forms of lyme disease infections depending on the severity of symptoms 0107-0000-21-XXX-H01-P 0.2 CEU/2.0 Hrs (Knowledge) Initial Release Date: 02/23/21 Expiration Date: 02/23/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

In December 2020, the American College of Cardiology published an Expert Consensus Decision Pathway for Antithrombotic Therapy in Patients undergoing Percutaneous Coronary Intervention. This guideline addresses a timely problem of patients on anticoagulation and antiplatelet therapy. This episode is accredited for CPE. Subscribe at CEimpact ( https://www.ceimpact.com/pharmacist ) and claim your CE today! Reference: 2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. Dec 18, 2020. Epublished DOI: 10.1016/j.jacc.2020.09.011. Accessed at https://www.jacc.org/doi/10.1016/j.jacc.2020.09.011 CPE details for GameChangers Podcast January 2021 Learning Objective: Recommend an appropriate antithrombotic/anticoagulant regimen in a patient who has received percutaneous coronary intervention with stenting 0107-0000-21-079-H01-P 0.2 CEU/2.0 Hrs (Knowledge) Initial Release Date: 01/25/21 Expiration Date: 01/26/24 Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

The unbelievable happened in 2020 - a vaccine was developed with high efficacy within 12 months for a novel virus! In December two vaccines for the prevention of the SARS-CoV-2 virus were approved through Emergency Use Authorization in the US. Is it time to get a shot? This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! Reference: Polack F, Thomas S, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. NEJM. Dec 10, 2020. DOI: 10.1056/NEJM2034577 Baden L, El Sahly H, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. NEJM. Dec 30, 2020. DOI: 10.1056/NEHMoa2035389 ACIP Recommendations: https://www.cdc.gov/vaccines/hcp/acip-recs/vacc-specific/covid-19.html  See omnystudio.com/listener for privacy information.

Every December, the American Diabetes Association updates the Standards of Medical Care in Diabetes. The guidelines cover sixteen sections from diabetes advocacy to technology updates. Start 2021 off right - learn what changed and what matters most for individuals with diabetes. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! Reference: American Diabetes Association. Standards of Medical Care in Diabetes - 2021. Diabetes Cares. January 01, 2021; volume 44, issue supplement 1. https://care.diabetesjournals.org/content/44/Supplement_1  Disclosure: Dr. Jake Galdo is a speaker for Novo Nordisk in 2021. See omnystudio.com/listener for privacy information.

Myopathy is a common reason for discontinuation of statin medications. The recent SAMSON study examined the nocebo effect and how this may bias patients towards treatment failure. How can clinicians overcome the nocebo effect? This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! Reference: Wood F, Howard J, Finegold J, et al. N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects. N Engl J Med 2020; 383:2182-2184. DOI: 10.1056/NEJMc2031173 See omnystudio.com/listener for privacy information.

The efficacy of antiretroviral therapy has led to persons with HIV living a near-normal lifespan. But medications only work when used appropriately. The International Antiviral Society-USA Panel published updated recommendations for the treatment and prevention of HIV infections. Treatment of HIV may be distilled into a simple idea - two "nucs" and something else. Learn how to optimize care for your patients. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! Reference: Saag MS, Gandhi RT, Hoy JF, et al. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2020 recommendations of the International Antiviral Society-USA Panel. JAMA. 2020;324(16):1651-1669. Available at: https://www.iasusa.org/2020/11/12/antiretroviral-drugs-treatment-prevention-hiv-infection-adults-2020-recommendations-of-the-international-antiviral-society-usa-panel/  The CE for this episode is supported by an educational grant from Xellia Pharmaceuticals, a specialty pharmaceutical company focused on providing important anti-infective treatments against serious and often life-threatening infections.  See omnystudio.com/listener for privacy information.

Clostridioides difficile is an important cause of morbidity and mortality in the United States with over 500,000 infections annually. The Infectious Disease Society of America released a clinical quality measure focused on treatment of c diff in March 2020. A review of the diagnosis and treatment will help providers improve quality. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! The CE for this episode is supported by an educational grant from Xellia Pharmaceuticals, a specialty pharmaceutical company focused on providing important anti-infective treatments against serious and often life-threatening infections.  See omnystudio.com/listener for privacy information.

The question of acetaminophen versus ibuprofen may finally be laid to rest. A recent meta-analysis compared the efficacy and safety of ibuprofen versus acetaminophen for the treatment of fever or pain in children younger than 2 years. Is there a drug of choice? Reference: Tan E, Braithwaite I, McKinlay CJD, Dalziel SR. Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(10):e2022398. doi:10.1001/jamanetworkopen.2020.22398 This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! The CE for this episode is supported by an educational grant from Xellia Pharmaceuticals, a specialty pharmaceutical company focused on providing important anti-infective treatments against serious and often life-threatening infections.  See omnystudio.com/listener for privacy information.

In the never ending battle with COVID-19, new studies have demonstrated a role for IVIG in the treatment of acute COVID-19 pneumonia, the potential benefit of honey and black seed in mild to moderate COVID-19, and the efficacy of an mRNA vaccine. What does this all mean for current practice? Additional References: IVIG: Gharebaghi, N., Nejadrahim, R., Mousavi, S.J. et al. The use of intravenous immunoglobulin gamma for the treatment of severe coronavirus disease 2019: a randomized placebo-controlled double-blind clinical trial. BMC Infect Dis 20, 786 (2020). https://doi.org/10.1186/s12879-020-05507-4  Honey: Ashraf S, Ashraf S, Imran M, et al. Efficacy of honey and Nigella sativa against COVID-19: HNS-COVID-PK Trial. medRxiv 2020.10.30.20217364; doi: https://doi.org/10.1101/2020.10.30.20217364  Cleveland Clinic Hospitalization Risk for COVID-19 Positive Calculator: https://riskcalc.org/COVID19Hospitalization/  Cleveland Clinic Predict COVID-19 test result Calculator: https://riskcalc.org/COVID19/  This episode is accredited for CPE. Subscribe at CEimpact https://www.ceimpact.com/pharmacist and claim your CE today! The CE for this episode is supported by an educational grant from Xellia Pharmaceuticals, a specialty pharmaceutical company focused on providing important anti-infective treatments against serious and often life-threatening infections.  See omnystudio.com/listener for privacy information.

Atopic Dermatitis is not extensively taught in pharmacy curriculum. With several international medical societies publishing updated guidelines and newly approved medications, it's time for a review. Clinicians can learn ways to help treat patients under the skin. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! The CE for this episode is supported by an educational grant from Xellia Pharmaceuticals, a specialty pharmaceutical company focused on providing important anti-infective treatments against serious and often life-threatening infections.  See omnystudio.com/listener for privacy information.

The opioid epidemic is helping reduce prescriptions for opioid-based pharmacotherapy. However, parallel to this drop has been an increase in gabapentin and pregabalin prescriptions.  Why has this occurred and what should the clinician know about this phenomenon? Additional Resources/References: Trends, Patient and Prescriber Characteristics in Gabapentinoid Use in a Sample of United States Ambulatory Care Visits from 2003 to 2016. Zhou L, Bhattacharjee S, Kwoh CK, Tighe PJ, Malone DC, Slack M, Wilson DL, Brown JD, Lo-Ciganic WH. J Clin Med. 2019 Dec 29;9(1):83. doi:10.3390/jcm9010083. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

Sodium Glucose Co-Transporter-2 Inhibitors, a medication class for the treatment of diabetes, is now showing benefits in other medical conditions, like heart failure and kidney disease. Is this a class effect? Additional Resources/References: McGuire DK, Shih WJ, Cosentino F, et al. Association of SGLT2 Inhibitors With Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes: A Meta-analysis . JAMA Cardiol. Published online October 07, 2020. doi:10.1001/jamacardio.2020.4511 This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today!   See omnystudio.com/listener for privacy information.

Vancomycin, despite being around for decades, keeps having updates to dosing, formulations, and monitoring. It's important to stay updated on this vital medication for hospital and infusion center practitioners. Are you ready for the changes? Additional Resources/References: https://www.idsociety.org/practice-guideline/vancomycin/ This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! The CE for this episode is supported by an educational grant from Xellia Pharmaceuticals, a specialty pharmaceutical company focused on providing important anti-infective treatments against serious and often life-threatening infections.    See omnystudio.com/listener for privacy information.

A recently published Serial cross-sectional analysis of National Health and Nutrition Examination Survey data has been published suggesting that overall blood pressure control in adults with hypertension over the last 4 years has declined. Why is this? What tips can the pharmacist and prescriber use to improve control? Can these professionals work together to improve BP control? Can we survive under pressure? Additional Resources/References: Muntner P, Hardy ST, Fine LJ, et al. Trends in Blood Pressure Control Among US Adults With Hypertension, 1999-2000 to 2017-2018. JAMA. 2020;324(12):1190–1200. doi:10.1001/jama.2020.14545 This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

The LoDoCo2 Trial suggested that colchicine may improve outcomes in patients with cardiovascular disease. Can a 3,000 year old drug still be a miracle? Additional Resources/References: Nidorf SM, Fiolet ATL, Mosterd A, et al; LoDoCo2 Trial Investigators. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020 Aug 31. doi: 10.1056/NEJMoa2021372. Epub ahead of print. PMID: 32865380. This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

The fear of a "Twindemic," an influenza and COVID-19, double pandemic is starting to rise. But what does the data say about this fear? Is the US in double trouble with BOGO viral infections? This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

Updated osteoporosis guidelines have arrived from the American Association of Clinical Endocrinology. The AACE guidelines include different recommendations from the 2017 National Osteoporosis Foundation guidelines, primarily due to new anabolic agents. Learn about a newly created a new patient risk stratified category, the role of bisphosphonates, and how to approach patient care. Additional Resources/References: FRAX calculator: US version https://www.sheffield.ac.uk/FRAX/tool.aspx?country=9; AACE osteoporosis guidelines https://www.aace.com/disease-stateresources/reproductive-and-gonad/clinical-practiceguidelines-recent-news-and-updates This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

Medications are only 10 percent of total US healthcare expenditure, yet remain a focus of healthcare costs. In this Gamechangers episode, Geoff Wall and guest, Jake Galdo, will discuss two articles evaluating generic utilization on Medicare costs. By giving up brands, can we lower costs? Additional Resource/Reference: https://jamanetwork.com/journals/jamacardiology/article-abstract/2770174 and https://jamanetwork.com/journals/jama/fullarticle/2697695 This episode is accredited for CPE. Subscribe at CEimpact https://www.ceimpact.com/pharmacist  and claim your CE today!   See omnystudio.com/listener for privacy information.

Antibiotics are a risk factor for Clostridium difficile infections. Combining a review of the 2017 Infectious Diseases Society of America and recent literature for prophylactic therapies, learn how to care for patients between a rock and a hard place. Additional Resource/Reference: https://learn.ceimpact.com/library/group/12/course/2313  This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

The TAILOR-PCI Trial evaluates the outcomes between genotype-guided P2Y12 inhibitor selection versus conventional prescribing on ischemic outcomes. Listen to Geoff Wall and guest, Jake Galdo, discuss the role of pharmacogenomics in patient care. Additional Resource/Reference: https://jamanetwork.com/journals/jama/article-abstract/2769725  This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

New guidelines from American College of Physicians suggest that first-line treatment of non-low back musculoskeletal injuries are topical therapies. Topical non-steroidal anti-inflammatory drugs, like diclofenac, are available as over-the-counter products in the US. Learn about the preferred route of care when treating pain. Additional Resource/Reference: https://www.acpjournals.org/doi/10.7326/M19-3602  This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

Community Pharmacies are vital members of neighborhoods and the healthcare community. A major social determinant of health is access to healthcare - both providers and medications. Recently, Berenbrok and colleagues published research that showed community pharmacies are visited almost twice as much compared to primary care providers by Medicare beneficiaries annually. Guest Jake Galdo will be joining our host Geoff Wall to discuss how community pharmacists provide care. Additional Resource/Reference: https://jamanetwork.com/journals/jamanetworkopen/fullarUcle/2768247  This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

The COVID-19 pandemic continues to rage on worldwide. Data surrounding the treatment of patients with COVID-19 respiratory failure is moving at lightning pace, so for this week's episode we will discuss the latest (as of 8/13/20) information surrounding two modalities for COVID-19 treatment: convalescent plasma and tocilizumab.  This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! See omnystudio.com/listener for privacy information.

A recent retrospective database study found that in patients on new oral anticoagulants prescribed clarithromycin, compared to azithromycin, were assocated with an increased risk of major beeding. We will discuss this paper and other common drug interactions the practicing pharmacists should be vigilant about. This episode is accredited for CPE. For CE details and to claim credit, click here: https://bit.ly/3gvDKKA  See omnystudio.com/listener for privacy information.

A recent study suggests that SGLT2 drugs - now shown to dramatically improve cardiovascular and renal outcomes in a wide variety of patients - have a higher incidence of euglycemic DKA than previously thought.  If pharmacists see more of this ADR, how do we treat appropriately - especially when a patient's sugars may not be very high? This episode is accredited for CPE. For CE details and to claim credit, click here: https://bit.ly/3gy7F4O  See omnystudio.com/listener for privacy information.

Most prescribers believe that short course of steroids have no serious adverse effects, but a recent study from the Annals of Internal Medicine challenges that notion.  What does the pharmacist need to know about the short and long term adverse effects of steroids and how to proactively prevent them? Additional Resources/References Association between Oral Corticosteroid Bursts and Severe Adverse Events: https://www.acpjournals.org/doi/pdf/10.7326/M20-0432  This episode is accredited for CPE. For CE details and to claim credit, click here: https://bit.ly/2XxYr0T  See omnystudio.com/listener for privacy information.

Ethanol use disorder continues to be a major problem in the U.S.  The stress and anxiety related to the COVID-19 pandemic may exacerbate alcohol use disorder. Tune in to this episode to learn the latest in guideline updates relative to the management of ethanol withdrawal. Additional Resources/References Alcohol Withdrawal Management Guideline: https://www.asam.org/Quality-Science/quality/guideline-on-alcohol-withdrawal-management This episode is accredited for CPE. For CE details and to claim credit, click here: https://bit.ly/2OB3RDi  See omnystudio.com/listener for privacy information.

Geoff Wall, PharmD delivers another great podcast. Pharmacists see skeletal muscle relaxant prescriptions daily but how much real experience  do we  have with these drugs?  Do they work?  Are they safe?  This episode covers what should every pharmacist know about these medications. This episode is accredited for CPE. For CE details and to claim credit, click here: https://bit.ly/2CEy161  See omnystudio.com/listener for privacy information.

Overinflamation or cytokine storm is said to be the driver of acute respiratory disorder disease (ARDS) in COVID patients.   A recent study conducted in the United Kingdom suggests that the steroid dexamethasone may be a weapon for prevention.  In this episode, we discuss the study that caused the National Health Service in the U.K. and the CDC to change their recommendations for steroids and severe COVID. Additional Resources/References Ramdomised Evaluation of COVID-19 Therapy: https://www.recoverytrial.net/  This episode is accredited for CPE. For CE details and to claim credit, click here: https://bit.ly/3h8OfTR  See omnystudio.com/listener for privacy information.

The COVID-19 pandemic has disproportionally affected Latinx Americans.  Learn how pharmacists can optimize patient care for Latinx patients by discussing how to overcome economic and language barriers.  In this episode, we'll talk with Dr. Sally Haack who cares for Latinx patients on a daily basis in her pharmacy practice. Special guest: Sally Haack, PharmD, BCPS Associate Professor Drake University This episode is accredited for CPE.   For CE details and to claim credit click here: https://bit.ly/2YogiIp  See omnystudio.com/listener for privacy information.

Many patients over age 65 take daily medications that have anticholinergic properties. We know the addition of these drugs can affect quality of life and cognition.  In this episode, we talk with Dr. Kristin Meyer, an expert in geriatrics to  explore the latest data and discuss what Pharmacists can do to promote the appropriate use of anticholinergics. Additional Resources/References Beers Criteria: By the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019;67(4):674-694. doi:10.1111/jgs.15767 Anticholinergic Risk Scale: Rudolph JL, Salow MJ, Angelini MC, McGlinchey RE. The Anticholinergic Risk Scale and Anticholinergic Adverse Effects in Older Persons. Arch Intern Med. 2008;168(5):508–513. doi:10.1001/archinternmed.2007.106 Recent arge study associating anticholinergics with dementia: Coupland CAC, Hill T, Dening T, Morriss R, Moore M, Hippisley-Cox J. Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Intern Med. 2019;179(8):1084–1093. doi:10.1001/jamainternmed.2019.0677 This episode is accredited for CPE.  For CE details and to claim credit click here: https://bit.ly/2UT97Ww  See omnystudio.com/listener for privacy information.

The American College of Rheumatology recently published new guidelines for the treatment of Gout. While gout is well understood and the medications to treat gout are both effective and affordable, implementation of the new ARC guidelines will, ideally, lead to improved quality of care for patients with gout.  In this episode, Dr. Wall discusses guideline changes and important pearls so pharmacists may optimize medication therapy for patients suffering from gout. This episode is accredited for CPE.  For CE details and to claim credit click here: https://bit.ly/2YchMVZ  See omnystudio.com/listener for privacy information.

Racism is a public health emergency and a root cause of social determinants of health. If we are to practice patient-centered care, and education our pharmacists to better serve their patients, we ought to act to dismantle structural racism and start by having some honest conversations. In this episode, we'll talk with Dr. Vibhuti Arya about our role as pharmacists in addressing this public health emergency. Special Guest:  Vibhuti Arya, PharmD Associate Clinical Professor, St. John's University Clinical Advisor, New York City Department of Health and Mental Hygiene View Dr. Arya's Tedx Talk here: https://www.youtube.com/watch?v=vnYE0n7Tx_o  This episode is accredited for CPE.  For CE details and to claim credit click here: https://bit.ly/2BgRwRs  Racism, SDOH, social determinants of health, anti-racist   See omnystudio.com/listener for privacy information.

Recently news suggests low vitamin D levels have been associated with increased risk of COVID-related morbidity and mortality. We know that vitamin D is a safe fat soluable vitamin that is difficult to "overdose" on.  What should the pharmacist know in terms of repletion dose and signs of toxicity? Since many patients do not get enough vitamin D in their diets, large medical societies and organizations recommend daily vitamin D for this reason.   This episode will focus not on the claims of efficacy of Vitamin D in COVID, but will instead discuss how your patients can replete vitamin D levels and the risks of toxicity in overrepletion. This episode is accredited for CPE.  For CE details and to claim credit click here: https://bit.ly/2N87PCD  See omnystudio.com/listener for privacy information.

Recently, Remdesivir was given Emergency Use Authorization (EUA) status by the U.S. Food and Drug Administration (FDA) for use in COVID based on a heretofore unpublished study. The study, conducted by NIAID,  is the subject of this episode. This episode is accredited for CPE.  For CE details and to claim credit click here:  https://bit.ly/3hn191p  See omnystudio.com/listener for privacy information.

Buprenorphine has been shown in numerous studies to be safe and effective in opioid use disorder, yet < 10% patients with Opioid Use Disorder receive drug treatment. In this episode, we discuss what the general pharmacist needs to know about the most powerful weapon we have for Opioid Use Disorder: buprenorphine This episode is accredited for CPE.  This episode is accredited for CPE.  For CE details and to claim credit click here:  https://bit.ly/3dPEj0i  See omnystudio.com/listener for privacy information.

Geoff Wall, PharmD & Jamie Pitlick, PharmD discussing SGLT2 inhibitors, also called gliflozins, are a class of medications that inhibit reabsorption of glucose in the kidney and therefore lower blood sugar.  Recently SGLTs, which are currently indicated for Type 2 diabetes, have been investigated and received FDA approval for Heart failure with reduced ejection fraction (HFrEF).  Listen in to this episode to discover more about how these drugs work in this (HFrEF) disease state. This episode is accredited for CPE.  This episode is accredited for CPE.  For CE details and to claim credit click here:  https://bit.ly/2ApMvWw  See omnystudio.com/listener for privacy information.

GameChangers: In this episode, we describe the latest information concerning hypercoagulability with COVID-19 infection.  In this episode, we describe the latest information concerning hypercoagulability with COVID-19 infection.  Emerging evidence suggests that patients with COVID infection may be hypercoagulable and prone to clotting. Listen in as we discuss the evidence surrounding this issue and how to address therapeutic issues in anticoagulation in this population. This episode is accredited for CPE.  This episode is accredited for CPE.  For CE details and to claim credit click here:  https://bit.ly/3he73SF  See omnystudio.com/listener for privacy information.