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Depo-Provera was approved in 1992 by U.S. regulators. About 1 in 4 sexually active women in the United States have used the shot at some point, according to the U.S. Centers for Disease Control and Prevention (CDC). Meningiomas are common intracranial tumors with a female predominance. In fact, they are the most common primary brain tumor in women, with an incidence of approximately 12.76 per 100,000 in the general female population. The vast majority of these tumors are benign (World Health Organization [WHO] grade 1) while 15% to 20% of these tumors can behave atypically (WHO grade 2) and rarely, in 1% to 2% of cases, these tumors can be malignant (WHO grade 3). We covered the relationship between Depo-Provera, as a contraceptive agent, and brain meningiomas back in March 2024. With the increase in data, the ACOG released a patient centered counseling tool titled, “Counseling Patients on Birth Control Injection and Meningioma”. The most recent update on this story comes from the FDA, which has granted a medication label change to Depo-Provera (Pfizer) warning of this association. Even though association does not prove causation, the association between depo and meningiomas seems strong (with new data from the US). Does this warning extend to other progestins? Listen in for details. 1. https://podcasts.apple.com/us/podcast/dr-chapas-obgyn-clinical-pearls/id1412385746?i=10006508795722. ACOG's “Counseling Patients on Birth Control Injection and Meningioma” 3. https://www.statnews.com/pharmalot/2025/12/17/fda-pfizer-contraception-cancer-preemption-depoprovera/4. Xiao T, Kumar P, Lobbous M, et al. Depot Medroxyprogesterone Acetate and Risk of Meningioma in the US. JAMA Neurology. 2025;82(11):1094-1102. doi:10.1001/jamaneurol.2025.3011.5. de Dios E, Näslund O, Choudhry M, et al.Prevalence and Symptoms of Incidental Meningiomas: A Population-Based Study.Acta Neurochirurgica. 2025;167(1):98. doi:10.1007/s00701-025-06506-7.6. Schaff LR, Mellinghoff IK.Glioblastoma and Other Primary Brain Malignancies in Adults: A Review. JAMA. 2023;329(7):574-587. doi:10.1001/jama.2023.0023.7. BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-078078 (Published 27 March 2024) Cite this as: BMJ 2024;384:e078078
From Freudian fashion to sumptuous saris, courtly courtesans to iconic opera costumes, we take you "behind the seams" of our recent fashion history-packed day tours of New York City spent at the Fashion Institute of Technology, The New York Historical Society, The Metropolitan Opera and the Metropolitan Museum of Art. Further learning: Valerie Steele's Dress, Dreams, and Desire at the Museum at FIT The New York Sari and The Gay Harlem Renaissance at the New York Historical Discounted tickets for The Metropolitan Opera Antonio Ratti Center Noel Catherine Vorlée 1783 and ca. 1804 at the Metropolitan Museum of Art Man's Jama with Poppies Want more Dressed: The History of Fashion? Our website and classes Our Instagram Our bookshelf with over 150 of our favorite fashion history titles Learn more about your ad choices. Visit megaphone.fm/adchoices
Obesity affects more than 1 billion people worldwide and is recognized by the World Health Organization as a chronic, relapsing disease. WHO recently published a guideline in JAMA on the use and indications of GLP-1 therapies for the treatment of #obesity in adults. Francesca Celletti, MD, PhD, and Ezekiel Emanuel, MD, PhD, join JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss. Related Content: World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults
This episode centers on the critical gap in nutrition education within medical training and efforts to bridge it. Guest Akash Patel, a medical student who led a pilot nutrition curriculum, discusses why doctors receive little formal training in nutrition despite poor diet being a major driver of disease. With diet-related conditions (obesity, diabetes, cardiovascular disease, etc.) contributing heavily to morbidity and healthcare costs, the conversation highlights a pivotal push to better equip physicians in nutritional knowledge and counseling. Patel's work comes at a turning point: there are now calls for standardized nutrition competencies in medical education (e.g., a recent JAMA consensus) and a growing recognition that improving doctors' nutrition literacy could enhance patient care and public trust. But at the same time, medical programs already have a huge workload and little space is available for appropriate training. Others state that nutrition shouldn't fall within the remit of doctors. So how do we reconcile all this? While this episode focuses on the United States context, the concepts apply to other countries, as it outlines both the challenges and the emerging solutions for closing the nutrition training gap in medicine. Timestamps [03:21] Akash Patel's background and interests [05:22] Current state of nutrition education in medical schools [07:55] Akash's pilot program and initial findings [13:37] Challenges and considerations for curriculum integration [15:11] Effective curriculum design for nutrition education [23:38] Debating the role of nutrition education in medical training [29:00] Practical scenarios and the role of doctors [33:58] Advice for implementing nutrition education initiatives [38:15] Future directions in nutrition and medicine [43:07] Key ideas segment Links & Resources Go to episode page (with studies listed & linked) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Instagram: @withakashpatel @dannylennon_sigma @sigmanutrition
Welcome to Episode 51 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Segment 1 Rodríguez, M. Á., Quintana-Cepedal, M., Cheval, B., Thøgersen-Ntoumani, C., Crespo, I., & Olmedillas, H. (2025, October 7). Effect of exercise snacks on fitness and cardiometabolic health in physically inactive individuals: Systematic review and meta-analysis. British Journal of Sports Medicine. Advance online publication. https://doi.org/10.1136/bjsports-2025-110027 Rodgers, L. (2025, October 17). As pickleball continues to gain players, injuries are increasing. JAMA. https://doi.org/10.1001/jama.2025.18833 Segment 2 Baos, S., Lui, M., Walker-Smith, T., Pufulete, M., Messenger, D., Abbadi, R., Batchelor, T., Casali, G., Edwards, M., Goddard, N., Abu Hilal, M., Alzetani, A., Vaida, M., Martinovsky, P., Saravanan, P., Cook, T., Malhotra, R., Simpson, A., Little, R., Wordsworth, S., Stokes, E., Jiang, J., Reeves, B., Culliford, L., Collett, L., Maishman, R., Chauhan, N., McCullagh, L., McKeon, H., Abbs, S., Lamb, J., Gilbert, A., Hughes, C., Wynick, D., Angelini, G., Grocott, M., Gibbison, B., & Rogers, C. A. (2025). Gabapentin for pain management after major surgery: A placebo-controlled, double-blinded, randomized clinical trial (the GAP Study). Anesthesiology, 143(4), 851-861. https://doi.org/10.1097/ALN.0000000000005655 NEJM Journal Watch. (2024, December 30). Growing evidence of harms associated with gabapentinoid drugs. JWatch. https://www.jwatch.org/na58203/2024/12/30/growing-evidence-harms-associated-with-gabapentinoid-drugs Moeindarbari, S., Beheshtian, N., & Hashemi, S. (2022). Cerebral vein thrombosis in a woman using oral contraceptive pills for a short period of time: A case report. Journal of Medical Case Reports, 16, Article 260. https://doi.org/10.1186/s13256-022-03473-w Peckham, A. M., Evoy, K. E., Ochs, L., & Covvey, J. R. (2018). Gabapentin for off-label use: Evidence-based or cause for concern? Substance Abuse: Research and Treatment, 12, 1178221818801311. https://doi.org/10.1177/1178221818801311 The 2 View: Emergency Medicine PAs & NPs. (2025, January 22). 41 – RCVS and CVT, CPR care science, prehospital tourniquets, blood pressure [Audio podcast episode]. Fireside. https://2view.fireside.fm/41 Strahan, A. E., Rikard, S. M., Schmit, K. M., Zhang, K., Guy, G. P., Jr., & [Additional Authors]. (2025). Trends in dispensed gabapentin prescriptions in the United States, 2010 to 2024. Annals of Internal Medicine. Advance online publication. https://doi.org/10.7326/ANNALS-25-01750 Segment 3 Brown, R. F., Lopez, K., Smith, C. B., & Charles, A. (2025). Diverticulitis: A review. JAMA, 334(13), 1180-1191. https://doi.org/10.1001/jama.2025.10234 Carr, S., & Velasco, A. L. (2024, July 25). Colon diverticulitis. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK541110/ Bob Tubbs on Emergency Radiology: https://youtu.be/Jg1JG67eoJQ Our social media: TikTok: https://www.tiktok.com/@ccmecourses Instagram: https://www.instagram.com/ccmecourses Facebook: https://www.facebook.com/CenterForMedicalEducation LinkedIn: https://www.linkedin.com/in/rickbukata Our podcasts: The 2 View Podcast (Free): Subscribe on Apple Podcasts https://apple.co/3rhVNZw Subscribe on Google Podcasts: http://bit.ly/2MrAHcD Subscribe On Spotify: http://spoti.fi/3tDM4im Risk Management Monthly Podcast (Paid CME): https://www.ccme.org/riskmgmt ** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. emergencymedicine #cme
In this episode, Michael speaks with attorney Shane Pennington, a leading expert on cannabis rescheduling, about reports that President Trump is preparing an executive order to reclassify marijuana from Schedule I to Schedule III. Pennington explains what a reclassification would mean for consumers, the legal cannabis industry, medical research, criminal justice, and state–federal power. Michael also explores the contrasting New York Times and JAMA analysis questioning the medical benefits of cannabis—and hears from listeners whose real-world experiences tell a different story. A fast-moving, deeply informative conversation about federal drug policy, politics, and the shifting landscape of cannabis in America. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.
TCW Podcast Episode 248 - An Act of Control We look at Japan's Act on Control and Improvement of Amusement Business and its impact on the arcade industry in Japan. In the late 1970s and early 1980s, video games became increasingly popular in Japan, drawing public concern over how much time and money players were spending in game centers. With little cultural context for games as entertainment, many assumed there must be some form of gambling or prize element involved, leading to growing moral panic. These concerns culminated in a 1985 amendment to an existing law that brought game centers under strict regulation. We examine the role of industry trade groups during this period, including the NRO, an operators organization that supported regulation under the belief it would disadvantage large arcades while leaving smaller venues such as department store rooftops and grocery stores unaffected. That assumption proved incorrect. At the same time, JAMA, representing manufacturers, organized its own operator segment to counter the NRO's influence. Because the law was written broadly, regulators were left to define what qualified as a controlled amusement, resulting in a chilling effect on arcades across Japan. These regulations reshaped the industry and pushed many companies to shift their focus toward home consoles and other markets. TCW 008 - Birth of the Japanese Game Center: https://podcast.theycreateworlds.com/e/birth-of-the-japanese-game-center/ Act on Control and Improvement of Amusement Business: https://www.japaneselawtranslation.go.jp/en/laws/view/4234/en Abroad in Japan - Pachinko - Japan's Biggest Gaming Obsession: https://www.youtube.com/watch?v=-tBy2jemw4s Masumi Akagi - "It Started with Pong": https://www.amazon.co.jp/%E3%81%9D%E3%82%8C%E3%81%AF%E3%80%8C%E3%83%9D%E3%83%B3%E3%80%8D%E3%81%8B%E3%82%89%E5%A7%8B%E3%81%BE%E3%81%A3%E3%81%9F-%E3%82%A2%E3%83%BC%E3%82%B1%E3%83%BC%E3%83%89TV%E3%82%B2%E3%83%BC%E3%83%A0%E3%81%AE%E6%88%90%E3%82%8A%E7%AB%8B%E3%81%A1-%E8%B5%A4%E6%9C%A8%E7%9C%9F%E6%BE%84/dp/4990251202 Rotamint - "Royal Super": https://www.youtube.com/watch?v=KRPBQ2cwAas Rotomint - Jackpot: https://www.youtube.com/watch?v=RgrmntnQfP4 TCW 077 - Invading Taito Part 1: https://podcast.theycreateworlds.com/e/invading-taito-part-1/ TCW 078 - Invading Taito Part 2: https://podcast.theycreateworlds.com/e/invading-taito-part-2/ TCW 195 - Finding Video Game Copyright: https://podcast.theycreateworlds.com/e/finding-video-game-copyright Sun Electronics - The Guiness: www.youtube.com/watch?v=zsJHEJHTU1M Fred Rogers Congress Public Funding: https://www.youtube.com/watch?v=fKy7ljRr0AA New episodes are on the 1st and 15th of every month! TCW Email: feedback@theycreateworlds.com Twitter: @tcwpodcast Patreon: https://www.patreon.com/theycreateworlds Alex's Video Game History Blog: http://videogamehistorian.wordpress.com Alex's book, published Dec 2019, is available at CRC Press and at major on-line retailers: http://bit.ly/TCWBOOK1 Intro Music: Josh Woodward - Airplane Mode - Music - "Airplane Mode" by Josh Woodward. Free download: http://joshwoodward.com/song/AirplaneMode Outro Music: RoleMusic - Bacterial Love: http://freemusicarchive.org/music/Rolemusic/Pop_Singles_Compilation_2014/01_rolemusic_-_bacterial_love Copyright: Attribution: http://creativecommons.org/licenses/by/4.0/
Un caro ascoltatore mi segnala un articolo uscito su JAMA, il Journal of the American Medical Association, in cui si parla dell'effetto del divieto di usare una serie di parole sul sistema sanitario statunitense. Ma cosa succede quando “chi comanda” manomette le parole, sia negli Stati Uniti sia da noi? La parola della settimana è omonazionalismo. - When Words Disappear: How Banning Words Imperils Health Care Communication- Atreju, Bernini contestata dagli studenti di Medicina: “Siete sempre dei poveri comunisti”- Simone Alliva, newsletter Prima che sia notte Ci sono anche altri podcast del Post: la rassegna stampa Morning, le Altre Indagini di Stefano Nazzi, gli approfondimenti di Francesco Costa su Wilson, e molti altri che parlano di scienza, esteri, linguaggio. E poi c'è quello su Sanremo. Sono i podcast dedicati a chi ha un abbonamento al Post, che a Natale puoi regalare, o farti regalare. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup. Related Content: Research of the Year 2025
Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, Preeti Malani, MD, MSJ, Deputy Editor, and Christopher W. Seymour, MD, MSc, Associate Editor of JAMA, the Journal of the American Medical Association, for articles published from December 6-12, 2025.
durée : 00:03:59 - Chroniques littorales - par : Jose Manuel Lamarque - Olivier Guyonvarch a été ambassadeur de France en Jamaïque et représentant permanent auprès de l'Autorité Internationale des Fonds Marins. C'est la raison pour laquelle on l'appelle le diplomate marin... Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
Send us a textContent warning: There is a discussion of suicide and self-harm during this episode. It is important and contextualised but this is a content warning nonetheless. If you are struggling, there is help available. In the UK, you can call Samaritans free on 116 123, You can also email jo@samaritans.org. If phone calls aren't accessible for you, text SHOUT to 85258.In the US, call or text 988 for the Suicide and Crisis Lifeline. They also have a web chat. And there's the Crisis Text Line - text HELLO to 741741.Elsewhere, the International Association for Suicide Prevention has a directory of crisis centres worldwide www.iasp.info Papers used in preparation of this episode include:Link to Roper et al. 2025 https://link.springer.com/article/10.1186/s13229-025-00693-x Link to Chikaura et al. 2025 https://onlinelibrary.wiley.com/doi/10.1002/aur.70137 Link to 2023 meta-analysis: https://link.springer.com/article/10.1186/s13229-023-00544-7Link to DBT RCT: https://www.cambridge.org/core/journals/psychological-medicine/article/effectiveness-and-safety-of-dialectical-behavior-therapy-for-suicidal-ideation-and-behavior-in-autistic-adults-a-pragmatic-randomized-controlled-trial/4464CA3C0D3DDEF5F3A4BD45415B9B50Link to AASP download: https://research.ncl.ac.uk/neurodisability/leafletsandmeasures/autismadaptedsafetyplans/Link to UK Suicide Prevention Strategy: https://www.gov.uk/government/publications/suicide-prevention-strategy-for-england-2023-to-2028Link to JAMA paper on autism/TGNC intersection: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824667Autistic identity systematic review: https://pubmed.ncbi.nlm.nih.gov/38334318/Interpersonal Theory in autism: https://molecularautism.biomedcentral.com/articles/10.1186/s13229-022-00495-5Camouflaging and suicide: https://pubmed.ncbi.nlm.nih.gov/31820344/988 autism resources: https://988lifeline.org/help-yourself/if-youre-neurodivergent/Autistica suicide page: https://www.autistica.org.uk/what-is-autism/suicide-and-autismTrevor Project autism brief: https://www.thetrevorproject.org/research-briefs/mental-health-among-autistic-lgbtq-youth-apr-2022/Warning signs resource (988): https://988lifeline.org/wp-content/uplAs ever we thank you, our loyal listeners for sticking with us. We would love to hear from you so look for our contact details in your podcast app or via our website.
In this episode, Dr. Zanotti discusses the role of Procalcitonin in the ICU. He is joined by Dr. Simran Gupta, an infectious disease specialist at Brigham & Women's Hospital in Boston. Dr. Gupta has additional training in Clinical Research, Transplant, and Infectious Disease. She recently published an article on reassessing the role of Procalcitonin in critically ill patients with sepsis. Additional resources: Reassessing Procalcitonin-Guided Antibiotic Therapy in Critically Ill Patients with Sepsis: Lessons from the ADAPT-Sepsis Trial. S. Gupta, et al. Clinical Infectious Disease 2025: https://pubmed.ncbi.nlm.nih.gov/40579227/ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial. JAMA 2025: https://pubmed.ncbi.nlm.nih.gov/39652885/ Procalcitonin-guided antibiotic therapy may shorten the length of treatment and may improve survival- a systematic review and meta-analysis. M Papp, et al. Crit Care 2023: https://pubmed.ncbi.nlm.nih.gov/37833778/ Books and entertainment mentioned in this episode: Shantaram: A Novel. By Gregory David Roberts: https://bit.ly/4ovVHKX SHANTARAM – Apple TV series: https://tv.apple.com/us/show/shantaram/umc.cmc.atxsrive40xli3zh3uxjimut
Interview with Molly N. Huston, MD, and William A. Strober, MD, MSCI, authors of Biofeedback vs Respiratory Retraining for Inducible Laryngeal Obstruction: A Randomized Clinical Trial. Hosted by Paul C. Bryson, MD, MBA. Related Content: Biofeedback vs Respiratory Retraining for Inducible Laryngeal Obstruction
Dans ce nouvel épisode de Eau-de-Vie, nous vous proposons une immersion totale dans l'univers fascinant de Planteray Rum, guidés par la passion d'Angélique Jullienne, Directrice marketing et communication de la Maison Ferrand. Bien plus qu'une simple présentation de gamme, cet échange lève le voile sur la philosophie unique d'une maison qui redéfinit les codes du rhum.Au programme de cette conversation riche en enseignements :De Plantation à Planteray : Angélique revient sur les coulisses de ce changement d'identité historique. Découvrez pourquoi et comment, après plus de deux ans de recherches et d'introspection collective, la marque a choisi ce nouveau nom. Une évolution porteuse de sens.L'art du Double Vieillissement : C'est la signature gustative qui fait la renommée de Planteray Rum. Nous explorons cette technique séculaire remise au goût du jour par Alexandre Gabriel : une première maturation tropicale intense dans le pays d'origine (Barbade, Jamaïque, Fidji...), suivie d'un affinage en fûts de cognac au cœur de la Charente. Angélique nous explique comment cette méthode sculpte l'élégance et la complexité aromatique de cuvées emblématiques comme le fameux XO 20th Anniversary.L'Odyssée de la West Indies Rum Distillery : Voyagez jusqu'à la Barbade pour découvrir comment l'acquisition de cette distillerie mythique a transformé la maison. Des archives séculaires aux alambics restaurés, c'est un véritable laboratoire d'histoire et d'innovation. C'est ici qu'est né le projet fou du Cut & Dry, un rhum à la noix de coco 100% naturel. Vous apprendrez comment il a fallu quatre ans de R&D et un partenariat agricole durable avec les fermiers locaux pour capturer le vrai goût de la coco fraîche, sans aucun artifice.Engagement et Avenir : Enfin, l'épisode aborde la place de l'humain et l'inclusivité dans l'industrie des spiritueux, notamment à travers l'implication d'Angélique dans l'association Women Leading Rum.Une écoute incontournable pour comprendre ce qui se cache réellement derrière chaque bouteille de Planteray Rum et pour saisir l'âme d'une maison qui allie avec brio héritage séculaire et créativité débridée.Pour en savoir plus sur Planteray Rum et sa Tropical Week
Editor's Summary by Preeti Malani, MD, MSJ, and Christopher C. Muth, MD, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from November 22 - December 5, 2025.
In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Elizabeth H. Mack, MD, MS, FCCM, speaks with Rebecca Mitting, MD, MRCPCH, consultant pediatric intensivist and clinical lead for the PICU at Imperial College Healthcare NHS Trust in London. They discuss Dr. Mitting's article, “Sedation and Ventilator Weaning Bundle and Time to Extubation in Infants With Bronchiolitis: Secondary Analysis of the Sedation AND Weaning in Children (SANDWICH) Trial,” published in the April 2025 issue of Pediatric Critical Care Medicine. The SANDWICH trial, conducted in the United Kingdom, evaluated a nurse-led intervention of sedation scoring, goal-based sedation weaning, and protocolized extubation readiness testing. While the original trial demonstrated only a modest reduction in ventilation duration, Dr. Mitting's subgroup analysis of infants with bronchiolitis found a reduction of median time to successful extubation by approximately 16 to 17 hours. Dr. Mitting highlights the importance of these findings during the winter season when bronchiolitis drives up PICU occupancy and strain. The critical trade-off between minimizing ventilator days and avoiding extubation failure is discussed, as well as implementation challenges after the COVID-19 pandemic, the importance of protocolized care under resource strain, and future directions for predictive models and personalized strategies to optimize extubation timing. Listeners will gain practical insights into evidence-based approaches for improving outcomes in infants with bronchiolitis and the broader implications for PICU workflow and patient safety. Resources referenced in this episode: Sedation and Ventilator Weaning Bundle and Time to Extubation in Infants With Bronchiolitis: Secondary Analysis of the Sedation AND Weaning in Children (SANDWICH) Trial (Mitting RB, et al. Pediatr Crit Care Med. 2025;26:e423-e431). Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial (Blackwood B, et al. JAMA. 2021;326:401-410).
In this high-impact solo episode, Darin strips away the noise, hacks, and hype to deliver a clear, no-BS roadmap for transforming your body, brain, energy, and direction in life. This is a straight-talk breakdown of the 5 foundational habits that matter most — the habits backed by science, ancient wisdom, and Darin's decades-long experience living this work every day. Expect practical steps, micro-experiments, timing rules, and the mindset needed to reclaim sovereignty in a world full of distraction. If you're ready to build a stronger, clearer, more powerful version of yourself… this is the episode. What You'll Learn 00:00 – Welcome to SuperLife How this podcast helps you build sovereignty through real habits, real truth, and real practices. 03:07 – Why this episode is different Darin lays out the mission: habits, hacks, hard truths — without dogma or fluff. 03:44 – The 5 foundational moves that change your biology A preview of the metabolic, physical, mental, and behavioral levers that create huge shifts. 1. METABOLIC EDGE — Eat Like You're Building a Future 04:03 – Terrain theory + why your food timing matters How altering the internal environment of your cells changes everything. 05:02 – The two levers that unlock metabolic health Time-restricted eating + plant-forward whole foods. 05:23 – Compressing your eating window Why 8–10 hours is ideal, how it improves glucose, insulin, weight, and inflammation. 06:18 – Practical weekly ramp-up Week 1: 12 hours. Week 2: 8–10 hours. Simple, sustainable, achievable. 07:10 – Darin's personal eating window 10 a.m. to 6 p.m. — and why eating earlier aligns with digestive fire. 2. MOVEMENT THAT MATTERS — Strength Is Survival 11:04 – Why strength training is non-negotiable Muscle protects metabolism, bone density, insulin sensitivity, and longevity. 11:51 – What the evidence says Huge cohort studies show strength training reduces all-cause mortality. 12:23 – The perfect weekly formula 3x/week compound lifts + daily movement + micro-bursts every hour. 13:06 – Real-life practicality Darin's routine of walking, sprinting dogs, mountain biking, and breaking up the day with movement. 3. SLEEP — The Ultimate Biological Reset 16:26 – The truth everyone ignores You cannot out-supplement or out-biohack poor sleep. 16:40 – The real impact of chronic sleep loss Cognition, memory, hormones, emotional regulation — all decline. 17:37 – The universal rule: consistent timing Same bedtime ± 30 minutes, every night. 17:52 – 60-minute wind-down protocol Screens off, light down, nervous system softening. 18:32 – Using sauna as a down-regulation tool Infrared benefits + why Darin does it twice a day in winter. 4. MINDSET & CONSCIOUSNESS — Your Attention Is Your Power 20:00 – Why optimization fails without attention training You can master food, workouts, and sleep — but scattered attention destroys progress. 20:48 – Darin's morning protocol Water → elixir → infrared pad → meditation → visualization → journaling. Every day. Everywhere. 21:01 – Meta-analysis proof Meditation reduces anxiety, depression, stress — and rewires your brain. 21:23 – The perfect 10-minute breathwork formula 5–5–5–5 or 4–4–4–4 cycles for nervous system reset. 21:56 – Journaling as medicine Stream-of-consciousness to activate clarity and emotional release. 5. WEALTH — Treat Your Time Like Capital 22:36 – Redefining wealth It's not money — it's your magnetism, output, relationships, and purpose. 23:16 – The compounding effect of tiny decisions Time batching, micro-actions, and protecting your attention from the social media attention economy. 24:02 – Mini productivity framework 90 seconds → 3 important calls. Every Friday → 1 paragraph on what scaled this week. 25:14 – Darin's post-meditation rule No scrolling — replace with proactive actions: reading, outreach, Patreon replies. FINAL TAKEAWAYS 26:02 – The master checklist: • Time-restricted eating • Plant-focused meals • Resistance training • Daily meditation • Consistent sleep • Sauna recovery • Treating time like capital 26:11 – The real danger Chasing hacks before mastering fundamentals leads to burnout, confusion, and stress. 27:58 – Your power is in the basics These are simple, accessible, and life-changing. 28:04 – Closing message "Have your best Super Life Day ever." Thank You to Our Sponsors Our Place: Toxic-free, durable cookware that supports healthy cooking. Go to their website at fromourplace.com/darin and get 35% off sitewide in their largest sale of the year. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Key Takeaway "Your biology changes when your decisions change. Nail your sleep, nail your strength, honor your attention, and treat your time like capital — and you will build a Super Life from the ground up." Bibliography Time-restricted eating (human RCTs / reviews) — Wilkinson et al., 10-hour TRE reduced weight and improved cardiometabolic markers (2019). PMC Intermittent fasting / metabolic health review — comprehensive reviews showing metabolic switching benefits. PMC+1 Plant-forward/vegetarian diets & cardiometabolic outcomes — BMJ/Nutrition reviews and JAMA network evidence showing improved CVD risk markers and metabolic benefits. BMJ Nutrition+1 Sleep and cognition / brain health — Nature/Harvard coverage & meta-analyses: short sleep impairs cognition and links to amyloid processes. Nature+1 Resistance training & mortality / physical function — systematic and cohort evidence that muscle-strengthening activity lowers risk and preserves function. British Journal of Sports Medicine+1 Mindfulness & mental health meta-analysis — Goyal et al. 2014 and subsequent meta-analyses showing reductions in anxiety/stress. PubMed+1 Sauna bathing and cardiovascular outcomes — JAMA Internal Medicine / Mayo Clinic Proceedings reviews on sauna and lower CVD risk signals.
Christmas is a time of celebration, when friends and family gather to enjoy meals together. However, many of us overindulge, which leaves us feeling tired, bloated, and guilty. What actually happens to our bodies when we overeat, drink more, and swap fibre for sugar? And is there a way to enjoy the season's pleasures without starting January full of regret? In this episode, ZOE's Head Nutritionist, Dr Federica Amati, joins Jonathan to explore how festive food traditions shape our health and how to navigate them without guilt or restriction. Dr Federica shares practical suggestions for gut-friendly food swaps, festive traditions worth reviving, and the one ingredient she always includes on her own Christmas table. This episode is full of helpful advice on how to care for your body in a season that often asks us to do the opposite. Unwrap the truth about your food
Send us a Text Message (please include your email so we can respond!)Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/ANDROMEDA SHOCK 2(JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840823If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
In the last ten years, 'diagnostic stewardship' has emerged as a core principle of good clinical practice whose implementation impacts both the individual patient and public health at large. In this episode of Communicable, hosts Angela Huttner and Annie Joseph invite two experts in the field, Daniel Morgan (Maryland, USA) and Valerie Vaughn (Utah, USA), to discuss diagnostic stewardship in the context of infectious diseases, hospital medicine, and healthcare in general. Other topics covered include practical interventions for better testing practices and the role of artificial intelligence in the future of diagnostics. The episode highlights how thoughtful, intentional diagnostic practices can enhance clinician workflows and improve patient outcomes.This episode is a follow-up from Morgan's recently published commentary in CMI Communications on diagnostic testing, and the need for evaluating its clinical impact [1]. The episode was peer reviewed by Özlem Türkmen Recen of Çınarcık State Hospital, Yalova, Türkiye. ReferencesBaghdadi JD & Morgan DJ. Diagnostic tests should be assessed for clinical impact. CMI Comms 2024. DOI: 10.1016/j.cmicom.2024.105010Further readingAdvani S and Vaughn VM. Quality Improvement Interventions and Implementation Strategies for Urine Culture Stewardship in the Acute Care Setting: Advances and Challenges. Curr Infect Dis Rep 2021. DOI: 10.1007/s11908-021-00760-3 Core Elements of Hospital Antibiotic Stewardship Programs, https://www.cdc.gov/antibiotic-use/hcp/core-elements/hospital.html Core Elements of Hospital Diagnostic Excellence (DxEx), https://www.cdc.gov/patient-safety/hcp/hospital-dx-excellence/index.htmlCosgrove SE & Srinivasan A. Antibiotic Stewardship: A Decade of Progress. Infect Dis Clin North Am 2023. DOI: 10.1016/j.idc.2023.06.003 Dik JH, et al. Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship). J Clin Microbiol 2017. DOI: 10.1128/jcm.01283-17Fabre V, et al. Principles of diagnostic stewardship: A practical guide from the Society for Healthcare Epidemiology of America Diagnostic Stewardship Task Force. Infect Control Hosp Epidemiol 2023. DOI: 10.1017/ice.2023.5 Huttner A, et al. Re: ‘ESR and CRP: it's time to stop the zombie tests' by Spellberg et al. CMI 2025. DOI: 10.1016/j.cmi.2024.09.016 Morgan DJ, et al. Diagnostic Stewardship—Leveraging the Laboratory to Improve Antimicrobial Use. JAMA 2017. DOI: 10.1001/jama.2017.8531 Messacar K, et al. Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol 2017. DOI: 10.1128/jcm.02264-16Messacar K, et al. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022. DOI: 10.1016/j.jpeds.2022.02.002 Qian ET, et al. Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial. JAMA 2023. DOI: 10.1001/jama.2023.20583 Siontis KC et al. Diagnostic tests often fail to lead to changes in patient outcomes. J Clin Epidemiol 2014. DOI: 10.1016/j.jclinepi.2013.12.008Vaughn VM, et al. Antibiotic Stewardship Strategies and Their Association With Antibiotic Overuse After Hospital Discharge. Clin Infect Dis 2022. DOI: 10.1093/cid/ciac104Vaughn VM, et al. A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria. JAMA Intern Med 2023. DOI: 10.1001/jamainternmed.2023.2749
Brooklyn/ Botswana/Ariège x Paris/Londres/Kingston, à vos marques ! Notre 1ère invitée est l'artiste américaine Natalia M. King pour la sortie de son 8ème album Afroblues. Natalia M. King est une chanteuse, compositrice et guitariste américaine qui fusionne blues, jazz, soul et folk. Voix puissante du blues et du jazz modernes, elle captive par ses interprétations émouvantes. En 2025, elle franchit une nouvelle étape avec AfroBlues, un album mêlant pop dansante, afrobeat et sonorités blues. Son premier extrait, «Dumela», rend hommage à son voyage au Botswana, à sa terre rouge et à son peuple, capturant la beauté et la sagesse de ce lieu à travers sa musique. AfroBlues sera une fusion audacieuse des genres, réunissant les rythmes contagieux de l'afrobeat, des éléments de danse électronique et le soupçon de blues qui a défini sa carrière. Ce virage musical représente l'évolution continue de Natalia M. King en tant qu'artiste ne craignant pas d'expérimenter de nouveaux sons et styles. L'album est une exploration du rythme, de l'énergie et de la fusion culturelle, autour des thèmes de l'autonomisation, de la joie et de la résilience qui sont au cœur de l'album. Grâce à sa capacité à mélanger divers éléments musicaux, AfroBlues promet d'être un ajout unique et passionnant à sa discographie. À propos du premier single «Dumela» : Il existe un petit «Royaume-Uni» qui borde l'Afrique du Sud de Nelson Mandela. Une merveilleuse opportunité, par le biais de l'amour, m'y a transportée au printemps 2024 dans le merveilleux pays africain du Botswana. Les paysages, les odeurs et les sons m'ont rappelé des souvenirs oubliés. «Dumela», qui signifie bonjour en setswana (ou tswana), est mon hommage à cette mémoire oubliée et aux belles âmes que j'ai rencontrées là-bas. Je remercie les pluies et la terre rouge qui m'ont inspirée... Dumela Botswana ! Dumela Afrique ! Merci pour votre sagesse et nous nous reverrons. Natalia M. King Titres interprétés au grand studio - Dumela Live RFI - Lost & Everywhere, extrait de l'album - I Love A Woman Live RFI. Line Up : Natalia M. King (voix, guitare), Vince Laurent (batterie) & Damien Argentieri (claviers & moog). Son : Mathias Taylor & Jérémie Besset ► Album AfroBlues (Natalia M. King / Modulor 2025). Instagram - Facebook - YouTube. Puis nous recevons l'artiste britannique ALA.NI pour la sortie de Sunshine Music Lorsque ALA.NI a commencé à écrire Sunshine Music, son troisième album, l'hiver parisien de 2023 battait son plein, avec un froid mordant. Composant sous des couches de couettes dans son appartement de l'Opéra, elle puisait sa chaleur non pas dans son environnement, mais dans les souvenirs du soleil des Caraïbes qu'elle venait de quitter. Ce qui devait être un voyage de deux semaines en décembre 2020 s'est transformé en deux ans et demi entre la Barbade, la Grenade — où ses parents avaient grandi — puis la Jamaïque, un long séjour qui lui a offert un nouveau sentiment d'identité. «Vivre en Jamaïque, c'était la première fois que j'habitais dans un pays à majorité noire», dit-elle. «Les Jamaïcains sont très eux-mêmes, sans s'excuser. J'ai choisi de vivre à Paris, et je me sens plus moi-même, plus expressive et plus à l'aise ici qu'à Londres, et davantage appréciée et reconnue en tant qu'artiste aussi. Mais il y a des microagressions et des microracismes auxquels nous devons faire face chaque jour en tant que personnes de couleur. Quand je suis sortie de cet environnement, je me suis dit : «Merde, c'est ça que je gérais tout ce temps.» J'avançais simplement en acceptant certains comportements négatifs comme un acte de survie mentale.» En Jamaïque, elle a collaboré avec Sly Dunbar, l'un des batteurs légendaires de l'île, le sortant presque de sa retraite pour une session improvisée. Sunshine Music vibre du souvenir de cette chaleur : une tapisserie d'influences mêlant calypso, jazz, bossa nova et le grand répertoire d'après-guerre, le tout tissé par la voix et la sensibilité singulières d'ALA.NI. Tout au long de l'album, des styles familiers sont honorés sans pastiche : la langueur du reggae, le souffle d'un rythme bossa nova, la diction nette du théâtre musical. Titres interprétés au grand studio - Seaweed Live RFI - Tief, extrait de l'album - This is Why Live RFI. RFI Vidéos YT Line Up : Alani (chant), Thomas Naïm (guitare) Son : Mathias Taylor, Benoît Letirant ► Album Sunshine Music (No Format 2025). Instagram - Bandcamp - YT Concert 9 février 2026, Théâtre Athénée Louis Jouvet, Paris.
Brooklyn/ Botswana/Ariège x Paris/Londres/Kingston, à vos marques ! Notre 1ère invitée est l'artiste américaine Natalia M. King pour la sortie de son 8ème album Afroblues. Natalia M. King est une chanteuse, compositrice et guitariste américaine qui fusionne blues, jazz, soul et folk. Voix puissante du blues et du jazz modernes, elle captive par ses interprétations émouvantes. En 2025, elle franchit une nouvelle étape avec AfroBlues, un album mêlant pop dansante, afrobeat et sonorités blues. Son premier extrait, «Dumela», rend hommage à son voyage au Botswana, à sa terre rouge et à son peuple, capturant la beauté et la sagesse de ce lieu à travers sa musique. AfroBlues sera une fusion audacieuse des genres, réunissant les rythmes contagieux de l'afrobeat, des éléments de danse électronique et le soupçon de blues qui a défini sa carrière. Ce virage musical représente l'évolution continue de Natalia M. King en tant qu'artiste ne craignant pas d'expérimenter de nouveaux sons et styles. L'album est une exploration du rythme, de l'énergie et de la fusion culturelle, autour des thèmes de l'autonomisation, de la joie et de la résilience qui sont au cœur de l'album. Grâce à sa capacité à mélanger divers éléments musicaux, AfroBlues promet d'être un ajout unique et passionnant à sa discographie. À propos du premier single «Dumela» : Il existe un petit «Royaume-Uni» qui borde l'Afrique du Sud de Nelson Mandela. Une merveilleuse opportunité, par le biais de l'amour, m'y a transportée au printemps 2024 dans le merveilleux pays africain du Botswana. Les paysages, les odeurs et les sons m'ont rappelé des souvenirs oubliés. «Dumela», qui signifie bonjour en setswana (ou tswana), est mon hommage à cette mémoire oubliée et aux belles âmes que j'ai rencontrées là-bas. Je remercie les pluies et la terre rouge qui m'ont inspirée... Dumela Botswana ! Dumela Afrique ! Merci pour votre sagesse et nous nous reverrons. Natalia M. King Titres interprétés au grand studio - Dumela Live RFI - Lost & Everywhere, extrait de l'album - I Love A Woman Live RFI. Line Up : Natalia M. King (voix, guitare), Vince Laurent (batterie) & Damien Argentieri (claviers & moog). Son : Mathias Taylor & Jérémie Besset ► Album AfroBlues (Natalia M. King / Modulor 2025). Instagram - Facebook - YouTube. Puis nous recevons l'artiste britannique ALA.NI pour la sortie de Sunshine Music Lorsque ALA.NI a commencé à écrire Sunshine Music, son troisième album, l'hiver parisien de 2023 battait son plein, avec un froid mordant. Composant sous des couches de couettes dans son appartement de l'Opéra, elle puisait sa chaleur non pas dans son environnement, mais dans les souvenirs du soleil des Caraïbes qu'elle venait de quitter. Ce qui devait être un voyage de deux semaines en décembre 2020 s'est transformé en deux ans et demi entre la Barbade, la Grenade — où ses parents avaient grandi — puis la Jamaïque, un long séjour qui lui a offert un nouveau sentiment d'identité. «Vivre en Jamaïque, c'était la première fois que j'habitais dans un pays à majorité noire», dit-elle. «Les Jamaïcains sont très eux-mêmes, sans s'excuser. J'ai choisi de vivre à Paris, et je me sens plus moi-même, plus expressive et plus à l'aise ici qu'à Londres, et davantage appréciée et reconnue en tant qu'artiste aussi. Mais il y a des microagressions et des microracismes auxquels nous devons faire face chaque jour en tant que personnes de couleur. Quand je suis sortie de cet environnement, je me suis dit : «Merde, c'est ça que je gérais tout ce temps.» J'avançais simplement en acceptant certains comportements négatifs comme un acte de survie mentale.» En Jamaïque, elle a collaboré avec Sly Dunbar, l'un des batteurs légendaires de l'île, le sortant presque de sa retraite pour une session improvisée. Sunshine Music vibre du souvenir de cette chaleur : une tapisserie d'influences mêlant calypso, jazz, bossa nova et le grand répertoire d'après-guerre, le tout tissé par la voix et la sensibilité singulières d'ALA.NI. Tout au long de l'album, des styles familiers sont honorés sans pastiche : la langueur du reggae, le souffle d'un rythme bossa nova, la diction nette du théâtre musical. Titres interprétés au grand studio - Seaweed Live RFI - Tief, extrait de l'album - This is Why Live RFI. RFI Vidéos YT Line Up : Alani (chant), Thomas Naïm (guitare) Son : Mathias Taylor, Benoît Letirant ► Album Sunshine Music (No Format 2025). Instagram - Bandcamp - YT Concert 9 février 2026, Théâtre Athénée Louis Jouvet, Paris.
Cette semaine, focus sur une véritable légende de la musique : Jimmy Cliff. Premier artiste à faire rayonner le reggae bien au-delà des frontières de la Jamaïque, chanteur et compositeur, il a marqué l'histoire de ce genre engagé. De ses débuts marqués par la pauvreté à ses plus grands succès internationaux, il a consacré plus de 50 ans à une musique porteuse de sens. Décédé à l'âge de 81 ans ce lundi 24 novembre, il laisse derrière lui l'héritage d'un artiste qui voyait sa musique comme un moyen de rendre le monde meilleur.
The latest JAMA article on keratinocyte carcinomas
A couple of weeks ago, the FDA Commissioner published a WSJ oped “The FDA Liberates Women's Hormone Replacement Therapy” (←gift link) and, with other FDA colleagues, a JAMA essay entitled “Updated Labeling for Menopausal Hormone Therapy” (open-access). That change, and the data cited, led to a series of articles in the days that followed, such as at STAT News “FDA reverses decades-old warning on hormone therapy products for menopause. Agency says the treatments o!fer heart, brain, and bone health benefits” and at the Washington Post “The FDA finally corrects its error on menopause hormone therapy. Women have been needlessly scared away from effective treatments.” If you read through these links, you'll be confused. Does MHT have proven cognitive benefits? What about a study from 1991 that showed ~50% reduction of fatal heart events with MHT? Or the 35% decreased risk of Alzheimer's disease? Or the breast cancer increased risk attributed to medroxyprogesterone acetate?I turned to my go-to gynecologist truth teller, Dr. Jen Gunter, to get her review of the evidence. This is a complex topic, with old data from the 2002 Women's Heath Initiative (WHI), new reports since, population level analysis, changes in preparations of MHT including local delivery, and much more.Here is our conversation which isn't just about MHT but includes “Big Wellness” marketing direct to middle aged women, the new FDA approved drug for hot flashes, the $14 million cut of the NIH's Office of Women's Health , marked increase in philanthropic support of women's health research, the Surgeon General nominee, ovarian failure, and a lightning round on proven benefits of MHT.Here's a brief clip on her views of the women's health “wellness” predatorsWe also discussed the reasons for Dr. Gunter's planned move next year back to Canada after practicing gynecology for 3 decades in the United States. I referred to a recent GT I wrote about the WHI and the potential favorable impact of MHT on the immune system, as suggested by new data on organ clocks. That finding, which has been replicated, may be linked to healthy aging, extending healthspan.****************************Thanks to the >190,000 Ground Truths subscribers from every US state and 210 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile.If you found this interesting PLEASE share it!Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.Thank you Debbie Weil, Cynthia Brumfield, Sara Garcia, Harshi Peiris, Ph.D., Liane Moccia, and over 1,000 others for tuning into my live video with Dr. Jen Gunter! Join me for my next live video in the app. Get full access to Ground Truths at erictopol.substack.com/subscribe
durée : 00:05:57 - Dans la playlist de France Inter - Dans son cinquième album, la chanteuse hyper-star multiplie les cadences et les langues. Parmi les duos remarquables, celui de la reine du dancehall Jamaïcain Shenseea. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
durée : 00:56:11 - Very Good Trip - par : Michka Assayas - Ce soir, une seule voix, celle d'un précurseur qui vient de nous quitter. Et grâce auquel une île, la Jamaïque, qui n'avait jusque-là rien apporté à la musique à l'échelle du monde, s'est mise à exister. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
From 18th century London to the promise of a global cure: the 200-year history of Parkinson's disease. To mark the release of our 'Ask the MD' conversation with The Michael J. Fox Foundation for Parkinson's Research, and to welcome a new influx of listeners, we're sharing one of our very first episodes, first aired in August 2024. Watch our full 'Ask the MD' interview, focused on lifestyle strategies for boosting brain health, on the foundation's website: https://www.michaeljfox.org/news/lifestyle-strategies-boost-brain-health-ask-md-video Parkinson's, a neurodegenerative disorder most commonly characterized by tremors and other motor symptoms, is so complex, many medical professionals are starting to classify it as a group of diseases, rather than a single disease. In this episode, we explain those complexities, including: • The motor symptoms (e.g. cogwheel rigidity, bradykinesia) and non-motor symptoms (e.g. depression, sleep disorders) • How the industrial revolution may have brought about environmental factors which contribute to Parkinson's • The differences and similarities between Parkinson's and other neurodegenerative diseases, like Alzheimer's • How Parkinson's manifests in our brains • Why one nurse was able to detect Parkinson's through smell • The neurogenetics of Parkinson's, and the ethical quandaries of evolving genetic technology • Why lifestyle — nutrition, exercise, etc. — is so key to preventing and managing Parkinson's Joining us for this extensive conversation are three incredible guests: • Dr. Rachel Dolhun, Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research • Dr. Michael Okun, evolutionary biologist, movement disorders specialist, and Director of the Norman Fixel Institute for Neurological Diseases • Dr. Matthew Farrer, neurogenetics expert and Professor Of Neurology at the University of Florida 'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ 'Your Brain On... Parkinson's' • SEASON 6 • EPISODE 4 (SEASON 3 REUPLOAD) ————— LINKS Dr. Rachel Dolhun: At the Michael J. Fox Foundation: https://www.michaeljfox.org/bio/rachel-dolhun-md-dipablm 'Ask the MD' series: https://www.michaeljfox.org/ask-md The Michael J. Fox Foundation on YouTube: https://www.youtube.com/@michaeljfoxfoundation/videos Dr. Michael Okun: At the University of Florida: https://neurology.ufl.edu/profile/okun-michael/ The book 'Ending Parkinson's Disease': https://endingpd.org/ The Norman Fixel Institute: https://fixel.ufhealth.org/ Dr. Matthew Farrer: At the University of Florida: https://neurology.ufl.edu/profile/farrer-matthew/ ————— References: Bloem, B. R., Okun, M. S., & Klein, C. (2021). Parkinson's disease. The Lancet, 397(10291), 2284-2303. Morris, H. R., Spillantini, M. G., Sue, C. M., & Williams-Gray, C. H. (2024). The pathogenesis of Parkinson's disease. The Lancet, 403(10423), 293-304. Dorsey, E., Sherer, T., Okun, M. S., & Bloem, B. R. (2018). The emerging evidence of the Parkinson pandemic. Journal of Parkinson's disease, 8(s1), S3-S8. Dorsey, E. R., Okun, M. S., & Tanner, C. M. (2021). Bad Air and Parkinson Disease—The Fog May Be Lifting. JAMA neurology, 78(7), 793-795. Tsalenchuk, M., Gentleman, S. M., & Marzi, S. J. (2023). Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease. npj Parkinson's Disease, 9(1), 123. Reynoso, A., Torricelli, R., Jacobs, B. M., Shi, J., Aslibekyan, S., Norcliffe‐Kaufmann, L., ... & Heilbron, K. (2024). Gene–Environment Interactions for Parkinson's Disease. Annals of Neurology, 95(4), 677-687. Golsorkhi, M., Sherzai, A., & Dashtipour, K. The Influence of Lifestyle on Parkinson's Disease Management. In Lifestyle Medicine, Fourth Edition (pp. 919-924). CRC Press. Sherzai, A. Z., Tagliati, M., Park, K., Pezeshkian, S., & Sherzai, D. (2016). Micronutrients and risk of Parkinson's disease: a systematic review. Gerontology and geriatric medicine, 2, 2333721416644286. ————— FOLLOW US Join NEURO Instagram: @thebraindocs Website: TheBrainDocs.com More info and episodes: TheBrainDocs.com/Podcast
What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis! Intro 0:13 GCA at ACR 2025 00:30 How Brown has approached framing this episode 1:01 A primer leading us to GCA 3:15 Let's get to the story 4:02 The man who couldn't wear a hat 4:57 Dr. Bayard Horton's 7:40 A tangent on cluster headaches 8:27 Let's get back to GCA 13:16 The first temporal artery biopsy 14:28 Vision loss and other puzzle pieces of GCA 16:27 What about jaw claudication? 21:15 Could GCA be transmissible? Injecting ground temporal arteries into healthy volunteers 24:13 Oxygen? Histamines? Adrenal cortical extract? Looking for GCA treatments 26:55 Steroids and GCA 28:40 A quote from the 1959 Mayo Clinic Board of Governors 32:24 Extracranial involvement in GCA 33:24 When did we recognize aorta involvement? Syphilis enters the picture 35:08 A recap of the history of GCA 41:25 Thanks for listening 42:19 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Boes CJ, Cephalalgia. 2007;doi:10.1111/j.1468-2982.2007.01238.x Cummer CL, et al. JAMA. 1912;doi:10.1001/jama.1912.04270080101004 Horton BT, Proc Cent SOC Clin Res. 1946 Sproul EE, et al. Am J Pathol. 1937;PMID: 19970328 Disclosures: Brown reports no relevant financial disclosures.
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Jamil Abdullah Al-Amin, formerly known as civil rights leader H. Rap Brown, is an American Muslim cleric and former Black Power activist whose life has spanned community organizing, political leadership, and later religious guidance. He died this week at the age of 82 in a correctional medical facility. We'll talk with Kalonji Changa and Dhoruba Bin Wahad about his legacy. Kalonji Jama Changa is an organizer, founder of the FTP Movement, and the co-chair of the Urban Survival and Preparedness Institute and is co-founder of Black Power Media. He is also author of the bestselling book, “How to Build a People's Army” and co-producer of the documentary “Organizing is the New Cool.” Dhoruba bin Wahad is an American political activist and author, former leader of the New York Black Panther Party, and co-founder of the Black Liberation Army. He was one of the Panther 21 defendants charged in 1969 with conspiracy to attack New York City police stations. — Subscribe to this podcast: https://plinkhq.com/i/1637968343?to=page Get in touch: lawanddisorder@kpfa.org Follow us on socials @LawAndDis: https://twitter.com/LawAndDis; https://www.instagram.com/lawanddis/ The post Remembering Jamil Abdullah Al-Amin w/ Dhoruba Bin Wahad and Kalonji Jama Changa appeared first on KPFA.
Send us a message with this link, we would love to hear from you. Standard message rates may apply.Clear guidance on benefits, risks, and how the FDA's label changes shift conversations in the exam room about HRTNikki's Corner• Philly's first Michelin stars and what the tiers mean• Flying taxis in Dubai • A cold case solved by college criminology studentsLearning • What HRT is, routes of therapy, and who benefits• Reframing WHI-era fears with age and timing data• FDA label changes and clinical implications• Contraindications and safer use considerations• Women's health bias and the cost of not listening• Practical steps for shared decisions with cliniciansReferencesThe 2022 Hormone Therapy Position Statement of the North American Menopause Society. Menopause (New York, N.Y.). 2022;29(7):767-794. doi:10.1097/GME.0000000000002028.Management of Menopausal Symptoms: A Review. Crandall CJ, Mehta JM, Manson JE. JAMA. 2023;329(5):405-420. doi:10.1001/jama.2022.24140.Hormone Therapy for Postmenopausal Women. Pinkerton JV. The New England Journal of Medicine. 2020;382(5):446-455. doi:10.1056/NEJMcp1714787.Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement. Grossman DC, Curry SJ, Owens DK, et al. JAMA. 2017;318(22):2224-2233. doi:10.1001/jama.2017.18261.Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. Gartlehner G, Patel SV, Reddy S, et al. JAMA. 2022;328(17):1747-1765. doi:10.1001/jama.2022.18324.Hormone Therapy in the Postmenopausal Years: Considering Benefits and Risks in Clinical Practice. Genazzani AR, Monteleone P, Giannini A, Simoncini T. Human Reproduction Update. 2021;27(6):1115-1150. doi:10.1093/humupd/dmab026.Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment. Flores VA, Pal L, Manson JE. Endocrine Reviews. 2021;42(6):720-752. doi:10.1210/endrev/bnab011.The Women's Health Initiative Randomized Trials and Clinical Practice: A Review. Manson JE, Crandall CJ, Rossouw JE, et al. JAMA. 2024;331(20):1748-1760. doi:10.1001/jama.2024.6542.Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. Mangione CM, Barry MJ, NicSupport the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski
Editor's Summary by Linda Brubaker, MD, and Preeti Malani, MD, MSJ, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from November 15-21 2025.
Major medical societies broadly support the FDA's removal of most boxed warnings from menopausal hormone therapy, emphasizing improved access and the importance of individualized risk assessment. The Americas have lost their measles-free status due to persistent outbreaks driven by low vaccination coverage, prompting PAHO to call for renewed immunization efforts and stronger surveillance. A randomized trial in JAMA found that moderate caffeinated coffee intake may reduce recurrence of atrial fibrillation after cardioversion compared with abstinence.
Radio foot internationale le jeudi 20 novembre 2025 (16h10 TU & 21h10 TU). Au programme : une finale africaine, un tirage explosif, un bilan européen et une nuit de sacres. ; CAF Awards 2025 : Hakimi au sommet, Mayele honoré ; - Mondial 2026 – Barrages Europe & Afrique : les affiches tombent ; - Éliminatoires Europe – Les favoris au rendez-vous ? ; - Finale CAF Ligue des champions féminine : AS FAR – ASEC Mimosas. CAF Awards 2025 : Hakimi au sommet, Mayele honoré Achraf Hakimi (PSG / Maroc) sacré Joueur africain de l'année. Et Fiston Mayele (RDC) récompensé comme Meilleur joueur africain évoluant en Afrique : un signe fort pour le football congolais. Mondial 2026 – Barrages Europe & Afrique : les affiches tombent Tirage tendu : Italie – Irlande du Nord, Turquie – Roumanie, Danemark – Macédoine du Nord, Pays de Galles – Bosnie… Et côté africain, la RDC est fixée : les Léopards joueront leur billet pour le Mondial face au vainqueur de Jamaïque – Nouvelle-Calédonie. Une finale de barrage intercontinental à très haute pression pour rêver de l'Amérique du Nord. Éliminatoires Europe – Les favoris au rendez-vous ? France, Espagne, Allemagne, Portugal, Belgique : les grandes nations ont fait le boulot. D'autres devront encore passer par un barrage piégeux. Le point complet sur une campagne parfois limpide, parfois inquiétante. Finale CAF Ligue des champions féminine : AS FAR – ASEC Mimosas Vendredi en Égypte, les Marocaines de l'AS FAR retrouvent une finale qu'elles connaissent par cœur, face à l'ASEC Mimosas, la sensation ivoirienne de cette édition. Duel d'expérience, talent, et confirmation de l'essor du football féminin sur le continent. Autour d'Annie Gasnier : Hervé Penot, Ludovic Duchesne et Manuel Terradillos. Édition : David Fintzel — Technique/Réalisation : Laurent Salerno.
Radio foot internationale le jeudi 20 novembre 2025 (16h10 TU & 21h10 TU). Au programme : une finale africaine, un tirage explosif, un bilan européen et une nuit de sacres. ; CAF Awards 2025 : Hakimi au sommet, Mayele honoré ; - Mondial 2026 – Barrages Europe & Afrique : les affiches tombent ; - Éliminatoires Europe – Les favoris au rendez-vous ? ; - Finale CAF Ligue des champions féminine : AS FAR – ASEC Mimosas. CAF Awards 2025 : Hakimi au sommet, Mayele honoré Achraf Hakimi (PSG / Maroc) sacré Joueur africain de l'année. Et Fiston Mayele (RDC) récompensé comme Meilleur joueur africain évoluant en Afrique : un signe fort pour le football congolais. Mondial 2026 – Barrages Europe & Afrique : les affiches tombent Tirage tendu : Italie – Irlande du Nord, Turquie – Roumanie, Danemark – Macédoine du Nord, Pays de Galles – Bosnie… Et côté africain, la RDC est fixée : les Léopards joueront leur billet pour le Mondial face au vainqueur de Jamaïque – Nouvelle-Calédonie. Une finale de barrage intercontinental à très haute pression pour rêver de l'Amérique du Nord. Éliminatoires Europe – Les favoris au rendez-vous ? France, Espagne, Allemagne, Portugal, Belgique : les grandes nations ont fait le boulot. D'autres devront encore passer par un barrage piégeux. Le point complet sur une campagne parfois limpide, parfois inquiétante. Finale CAF Ligue des champions féminine : AS FAR – ASEC Mimosas Vendredi en Égypte, les Marocaines de l'AS FAR retrouvent une finale qu'elles connaissent par cœur, face à l'ASEC Mimosas, la sensation ivoirienne de cette édition. Duel d'expérience, talent, et confirmation de l'essor du football féminin sur le continent. Autour d'Annie Gasnier : Hervé Penot, Ludovic Duchesne et Manuel Terradillos. Édition : David Fintzel — Technique/Réalisation : Laurent Salerno.
Home-delivered DASH-patterned groceries paired with dietitian counseling meaningfully lowered blood pressure and LDL cholesterol among Black adults living in food deserts
In this episode, Dr. Sergio Zanotti discusses the assessment of peripheral perfusion as a tool to guide treatment in septic shock. Specifically, he dives into Capillary Refill Time. He is joined by Dr. Eduardo Kattan, a critical care and anesthesia physician. Dr. Kattan is an Assistant Professor at the Pontificia Catholic University of Chile, where he also serves as Adult Critical Care Program Director and Director of Research and Academics in the Department of Critical Care Medicine. A prolific investigator, he focuses his research on septic shock and medical education. Dr. Rattan is the Co-Principal Investigator of the recently published ANDROMEDA-SHOCK 2 clinical trial. Additional resources: Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock. The ANDORMEDA-SHOCK-2 Randomized Clinical Trial. JAMA 2025: https://jamanetwork.com/journals/jama/fullarticle/2840823 Effect of Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on. 28-Day Mortality Among Patients With Septic Shock. The ANDROMEDA-SHOCK Randomized Clinical Trial. JAMA 2019: https://jamanetwork.com/journals/jama/fullarticle/2724361 Perspectives on peripheral perfusion assessment. Eduardo Kattan, et al. Curr Opin Crit Care 2023: https://pubmed.ncbi.nlm.nih.gov/37078639/ Books mentioned in this episode: The Little Prince. By Antoine de Saint-Exupery: https://bit.ly/49YcSRJ The Autumn Ghost: How the Battle Against a Polio Epidemic Revolutionized Modern Medical Care. By Hannah Wunsch: https://bit.ly/4i9PiUf
Send us a Text Message (please include your email so we can respond!)Episode 78! We start our discussion of the trials that drop with ESICM with the much anticipated BICAR-ICU 2! Then we talk briefly about some changes to the SOFA score with the new SOFA-2 score. BICAR-ICU2: https://pubmed.ncbi.nlm.nih.gov/41159812/BICAR-ICU 2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840824SOFA-2: https://pubmed.ncbi.nlm.nih.gov/41159833/SOFA-2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840822If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-459 Overview: Cognitive decline risk may be reduced through modifiable lifestyle factors, creating an opportunity for early intervention in primary care. Join us as we review findings from the US POINTER trial, which evaluated the impact of structured vs. self-guided lifestyle interventions on the risk of cognitive decline in older adults. Come away with tips to apply this evidence in real-world scenarios with your patients. Episode resource links: Baker LD, Espeland MA, Whitmer RA, et al. Structured vs self-guided multidomain lifestyle interventions for global cognitive function: The US POINTER randomized clinical trial. JAMA. 2025;334(8):681-691. doi:10.1001/jama.2025.12923 Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10421):572-628. doi:10.1016/S0140-6736(24)01296-0 Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-459 Overview: Cognitive decline risk may be reduced through modifiable lifestyle factors, creating an opportunity for early intervention in primary care. Join us as we review findings from the US POINTER trial, which evaluated the impact of structured vs. self-guided lifestyle interventions on the risk of cognitive decline in older adults. Come away with tips to apply this evidence in real-world scenarios with your patients. Episode resource links: Baker LD, Espeland MA, Whitmer RA, et al. Structured vs self-guided multidomain lifestyle interventions for global cognitive function: The US POINTER randomized clinical trial. JAMA. 2025;334(8):681-691. doi:10.1001/jama.2025.12923 Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10421):572-628. doi:10.1016/S0140-6736(24)01296-0 Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Send us a message with this link, we would love to hear from you. Standard message rates may apply.We discuss a clear, practical guide to menopause, explaining what it is, why it happens, and how to manage the most common symptoms with everyday steps and evidence-based options. We set up next week's deep dive on hormone therap. • Defining menopause and typical timing• Why estrogen declines and bodywide effects• Common symptoms across sleep, mood, and metabolism• Hot flashes and night sweats frequency and duration• Vaginal and urinary symptoms that mimic UTIs• Bone density loss and changing heart risk• Lifestyle tactics that actually help• When to ask about hormonal and non-hormonal treatments• Teaser for hormone therapy update next weekSend us an email at yourcheckuppod@gmail.comReferences1. Menopause-Biology, Consequences, Supportive Care, and Therapeutic Options. Davis SR, Pinkerton J, Santoro N, Simoncini T. Cell. 2023;186(19):4038-4058. doi:10.1016/j.cell.2023.08.016.2. The Menopause Transition: Signs, Symptoms, and Management Options. Santoro N, Roeca C, Peters BA, Neal-Perry G. The Journal of Clinical Endocrinology and Metabolism. 2021;106(1):1-15. doi:10.1210/clinem/dgaa764.3. Management of Menopausal Symptoms: A Review. Crandall CJ, Mehta JM, Manson JE. JAMA. 2023;329(5):405-420. doi:10.1001/jama.2022.24140.4. Menopause. Davis SR, Lambrinoudaki I, Lumsden M, et al. Nature Reviews. Disease Primers. 2015;1:15004. doi:10.1038/nrdp.2015.4.5. Menopause: Physiology, Definitions, and Symptoms. Gatenby C, Simpson P. Best Practice & Research. Clinical Endocrinology & Metabolism. 2024;38(1):101855. doi:10.1016/j.beem.2023.101855.6. Reproductive Aging in Biological Females: Mechanisms and Immediate Consequences. Muhammad YA. Frontiers in Endocrinology. 2025;16:1658592. doi:10.3389/fendo.2025.1658592.7. Treating Menopause - MHT and Beyond. Davis SR, Baber RJ. Nature Reviews. Endocrinology. 2022;18(8):490-502. doi:10.1038/s41574-022-00685-4.8. Management of Perimenopausal and Menopausal Symptoms. Duralde ER, Sobel TH, Manson JE. BMJ (Clinical Research Ed.). 2023;382:e072612. doi:10.1136/bmj-2022-072612.9. Hormone Therapy for Postmenopausal Women. Pinkerton JV. The New England Journal of Medicine. 2020;382(5):446-455. doi:10.1056/NEJMcp1714787.10. An Empowerment Model for Managing Menopause. Hickey M, LaCroix AZ, Doust J, et al. Lancet (London, England). 2024;403(10430):947-957. doi:10.1016/S0140-6736(23)02799-X.11. Menopause. Carter AE, Merriam S. The Medical Clinics of North America. 2023;107(2):199-212. doi:10.1016/j.mcna.2022.10.003.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski
Date: November 12, 2025 Reference: Taccone et al. Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury The TRAIN Randomized Clinical Trial. JAMA 2024 Guest Skeptic: Dr. Alex Weiler is an Emergency Department staff physician in the Peterborough Regional Health Centre and is an associate professor with Queen’s University Department of Family Medicine. […] The post SGEM#492: Give Blood – To Anemic Patients with Acute Brain Injuries first appeared on The Skeptics Guide to Emergency Medicine.
It's Nurse Practitioners Week, and today, we have a special episode to highlight a historic moment in time. On November 11, the FDA changed the labeling on hormone replacement therapy. Join me for a short, focused episode where I read a recently published JAMA article detailing those changes, to keep you up to date on this significant development. IN THIS EPISODE, YOU WILL LEARN: How recent FDA updates are changing menopausal hormone therapy The history of estrogen's role in heart and bone health How past research sparked fear around hormone therapy What the new labeling means for patients and prescribers How individualized treatment is reshaping dosage and timing decisions. Updated FDA labeling now distinguishes between systemic and topical therapies Key considerations for menopause-related urinary and genital health How these updates will potentially impact women's long-term health Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com
Since Democrats decided to shut down the government over Affordable Care Act subsidies, now's a good time for a deep dive into what they're even talking about. John Hopkins professor Dr. Ge Bai walks us through the ACA subsidies, the hidden mechanics behind the Affordable Care Act, and its illusion of "affordability." Dr. Bai shows us how regulations and subsidies have quietly reshaped the healthcare market - and how the free market can make it work for patients again. Ge Bai, PhD, CPA is a Professor of Accounting at Johns Hopkins Carey Business School and Professor of Health Policy & Management (joint) at Johns Hopkins Bloomberg School of Public Health. An expert on health care accounting, finance, and policy, Dr. Bai has testified before the House Ways and Means Committee and the Senate HELP Committee, written for the Wall Street Journal and the Washington Post, and published her studies in leading academic journals such as the New England Journal of Medicine, JAMA, and Health Affairs. Find her on X at @GeBaiDC and read her recent WSJ oped here: https://www.wsj.com/opinion/let-the-obamacare-enhanced-premium-subsidies-expire-16ef7e1b
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