Podcasts about Arc

Chrome 的時代即將終結？AI 正在改寫你的上網體驗！過去數十年，Chrome 幾乎是瀏覽器的代名詞，穩坐網路入口的霸主地位。但現在，一股強大的 AI 浪潮正從四面八方席捲而來，預示著一場前所未有的瀏覽器大戰！Google 剛剛才在反壟斷案中驚險過關，Chrome 卻意外免於拆分？ 與此同時，Perplexity Comet 以最強 AI 代理模式迅速圈粉，Atlassian 更豪擲 6.1 億美金，賭上一切要重新定義「知識工作者」的瀏覽器，連 OpenAI 都準備加入戰局！瀏覽器，這個你每天開啟無數次的應用，不再只是上網工具，它將成為你專屬的 AI 大腦！這集我們就來聊聊：

In this fourth episode of the Special Chronicles Podcast LIVE Coverage, host Daniel Smrokowski talks with Deanna E from Envision Unlimited. We're excited to announce that Special Chronicles provided exclusive LIVE and On-Demand Coverage of the The Arc of Illinois #SUSO2025 – the annual Speak Up and Speak Out Summit that celebrates the voices of people with disabilities. You'll hear directly from disability self-advocates, families, speakers, and professionals as they share their voices on leadership, advocacy, and inclusion. This annual self-advocacy conference empowers people with disabilities to speak up for themselves, take action, and create positive change in their communities. Let's Speak Up. Let's Speak Out. Let's Be Heard. Join The Conversation

"Search for Truth 65" | Pastor Evan Hood | 9.10.25 by ARC of Carson City, NV

In this third episode of the Special Chronicles Podcast LIVE Coverage, host Daniel Smrokowski talks with April McHenry and Leanne Mull who have been at the first SUSO 20 years ago. We're excited to announce that Special Chronicles provided exclusive LIVE and On-Demand Coverage of the The Arc of Illinois #SUSO2025 – the annual Speak Up and Speak Out Summit that celebrates the voices of people with disabilities. You'll hear directly from disability self-advocates, families, speakers, and professionals as they share their voices on leadership, advocacy, and inclusion. This annual self-advocacy conference empowers people with disabilities to speak up for themselves, take action, and create positive change in their communities. Let's Speak Up. Let's Speak Out. Let's Be Heard. Join The Conversation

In this second episode of the Special Chronicles Podcast LIVE Coverage, host Daniel Smrokowski talk to Eva Kott and her parents Michael and Alena about her self-advocacy story, first-time speaking at this conference, and her empowering story.  We're excited to announce that Special Chronicles provided exclusive LIVE and On-Demand Coverage of the The Arc of Illinois #SUSO2025 – the annual Speak Up and Speak Out Summit that celebrates the voices of people with disabilities. You'll hear directly from disability self-advocates, families, speakers, and professionals as they share their voices on leadership, advocacy, and inclusion. This annual self-advocacy conference empowers people with disabilities to speak up for themselves, take action, and create positive change in their communities. Let's Speak Up. Let's Speak Out. Let's Be Heard. Join The Conversation

In this episode of our kid-focused Dungeons & Dragons adventure, our heroes have finally gained access to the inner vault! As they seek answers, they discover one member of the party has secrets yet to be uncovered... To find StoryGuider: Coloring Book Adventures for Kids Ages 2-7, visit Backerkit or TTRPGKids.itch.io! About us: When kids are at the table, everyone wins! Playing TTRPGs levels up kids' critical thinking, creativity, communication, collaboration, & confidence. That's why we create our kid-inclusive D&D show, tips for playing with kids, and campaigns to bring the adventures home! Our Kids' Adventures:  Our Website Support Our Work:  Patreon Follow Us: YouTube, Instagram, TikTok, Facebook   Shoutout to our incredible partners: Emberglow Gaming - GM Shield (affiliate, 10% off: TheKidsTable) Roll & Play Press - D&D Ideas (10% off affiliate link) The Shop of Many Things - Puzzle Box (30% off affiliate link) 1985 Games - Maps (10% off: KIDSTABLE) DnD Adventure Club - Kids' Adventures (10% off: KIDSTABLE10) Monument Studios - Music (30% off: KIDSTABLE) Mordenkatie's Magnificent Minis - PC Minis (10% off: KIDSTABLE) Trillium Rose Acres - Monster Minis (15% off: THEKIDSTABLE) Daily Hero Forge - PC Mini Design Ember Rest - Game Host   0:00 Recap 0:20 Episode 17 (Skip Intro) 18:05 Arc 6 Interlude: Where's Vee Been? #dungeonsanddragons #actualplay #familyfriendly

Alex Jordan may spend his nine-to-five building animatronics and puppets for places like Universal and Disney, but that's just the beginning of his welding story. After hours, Alex runs his own job shop, dives into 3D printing as a fabrication tool, and shares his knowledge through YouTube and social media. In this episode, we talk about how 3D printers can transform a weld shop, the craftsmanship behind theme park projects like Raptors and parade floats, and how Alex turned a simple county fair project into a 15-year career. We also get into his custom electric pit bike builds, the importance of teaching what you know, and how community events like maker gift exchanges are fueling the next generation of creators. This conversation is full of innovation, hustle, and inspiration — don't miss it!   Arc Junkies Podcast: Instagram: @Arcjunkiespodcast YouTube: https://www.youtube.com/@arcjunkiespodcast9253 Email: Show@arcjunkies.com LinkedIn: https://www.linkedin.com/in/jason-becker-45407b72?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base_contact_details%3BKipEwR3uQXCmCjaEfNzo6w%3D%3D Arc Junkies Website: https://arcjunkies.com Arc junkies Merch: https://shop.threadmob.com/arcjunkie/shop/home Underground Metal Works: https://www.underground-metalworks.com/   Friends of the Show: American Welding Society Conferences Pipeline Conference https://www.aws.org/community-and-events/conferences-and-events/pipeline/ Use ARCJUNKIES at Checkout and get a free gift at the event.   Outlaw Leather LLC Outlawleather.com Instagram: @outlawleatherusa Use ARCJUNKIES for 15% off all in-stock leather goods     Everlast Welders Instagram: @everlastwelders  YouTube: Everlast Welders         Online: https://bit.ly/37xJstI Use Codeword ARCJUNKIES at checkout to get upgraded to a free Nova Foot Pedal and TIG Torch with the purchase of any machine that comes with a stock foot pedal and TIG Torch. Fronius: Instagram: @FroniusUSA Website: Fronius.us ISOTUNES: Instagram: @isotunesaudio Online: https://shop.isotunes.com/arcjunkies10.  Use ARCJUNKIES10 at checkout and save $10 on your purchase    

Atlassian compra The Browser Company por 610 millones, apostando por Dia como navegador empresarial con IA mientras Arc queda en mantenimiento. Una startup que prometía revolucionar la navegación prioriza el camino corporativo sobre la innovación radical.Loop Infinito, podcast de Applesfera, de lunes a viernes a las 7.00 h (hora española peninsular). Presentado por Javier Lacort. Editado por Alberto de la Torre.Contacto:lacort@xataka.comX: @jlacort

Matty Dalrymple talks with Michael La Ronn about FROM BETA READERS TO BETTER STORY, including how authors can use alpha readers, beta readers, and ARC teams to strengthen their manuscripts and connect with their audience. They discuss when to bring in beta readers, how to choose the right people, and the differences between feedback from writers versus readers. Michael also shares strategies for paying beta readers, managing volunteer feedback, and using early input to improve both your story and your marketing.   Interview video at https://bit.ly/TIAPYTPlaylist Show notes at https://www.theindyauthor.com/episodes-all   If you find the information in this video useful, please consider supporting The Indy Author! https://www.patreon.com/theindyauthor https://www.buymeacoffee.com/mattydalrymple   Michael La Ronn has published many science fiction & fantasy books and self-help books for writers. He built a writing career publishing many books per year while raising a family, working a full-time job, and even attending law school classes in the evenings. Visit his fiction website at www.michaellaronn.com and his resources for writers at www.authorlevelup.com   Matty Dalrymple is the author of the Lizzy Ballard Thrillers, beginning with ROCK PAPER SCISSORS; the Ann Kinnear Suspense Novels, beginning with THE SENSE OF DEATH; and the Ann Kinnear Suspense Shorts. She is a member of International Thriller Writers and Sisters in Crime. Matty also writes, speaks, and consults on the writing craft and the publishing voyage, and shares what she's learned on THE INDY AUTHOR PODCAST. She has written books on the business of short fiction and podcasting for authors; her articles have appeared in "Writer's Digest" magazine. She serves as the Campaigns Manager for the Alliance of Independent Authors.

In this first episode of the Special Chronicles Podcast LIVE Coverage, host Daniel Smrokowski talks with Speaker, Comedian and Television Writer Zach Anner about his Keynote Presentation “Joyful Grit: Turning Setbacks Into Setups” and about his role as a television writer on the hit ABC sitcom “Speechless. We're excited to announce that Special Chronicles provided exclusive LIVE and On-Demand Coverage of the The Arc of Illinois #SUSO2025 – the annual Speak Up and Speak Out Summit that celebrates the voices of people with disabilities. You'll hear directly from disability self-advocates, families, speakers, and professionals as they share their voices on leadership, advocacy, and inclusion. This annual self-advocacy conference empowers people with disabilities to speak up for themselves, take action, and create positive change in their communities. Let's Speak Up. Let's Speak Out. Let's Be Heard. Join The Conversation

Wade shares updates on Ally Munitions' latest projects, from new 6mm ARC barrels and small batch rifle releases to upcoming ammo offerings. He also breaks down the buzz around potential suppressor legislation and what it could mean for shooters. Plus, talk on 22 ARC, 6.5 Creedmoor, and more.Stay connected: https://allymunitions.com

Show DescriptionChris is updating us on the progress of his CSS reset, thoughts on The Browser Company and Arc being bought by Atlassian, and in 2025 why would anyone build a website? Listen on WebsiteLinks Bend Old-Time Jams and Events Join or Die Join or Die on Netflix Bowling Alone - Wikipedia Microsoft CTO Kevin Scott on the Birth of the Agentic Web - The Verge Chris' CSS Starter

Emmet Kennedy is joined by Adam Mills (Total Performance Data), Jamie Wrenn, and on-course bookmaker Michael Cannon to review a pivotal weekend in Europe's racing calendar. The Arc trials at Paris Longchamp reshaped the betting market, while shocks at Kempton and in the Moulin raised serious questions.

On this week's episode, Brad and Eric explore all the fun stuff in 40k. You know, same as last week but different. Meanwhile, Berilio quickly rushes this editing, including this text description, so he can lay down in bed and Silk his Song. Just tell Brad the edit job was good, I bet he won't test listen to know anyway.   POORHAMMER MERCH! https://orchideight.com/collections/poorhammer PATREON: https://www.patreon.com/SolelySingleton YOUTUBE: https://www.youtube.com/@thepoorhammerpodcast TWITCH: https://www.twitch.tv/poorhammer Website: https://poorhammer.libsyn.com/   RELATED TO THIS EPISODE: Every SPACE MARINE model: https://www.youtube.com/watch?v=ZO6xJGBM5lY Every AELDARI model: https://www.youtube.com/watch?v=oEnL6f1dV3Y Every ADEPTUS MECHANICUS model: https://www.youtube.com/watch?v=IkEdNsHul9E   TIMESTAMPS: 00:00 Hello and Welcome 01:05 Intro 02:56 Space Marines (SM) 07:35 Adepta Sororitas (Sisters) 11:03 Adeptus Custodes (Custodes) 12:02 Grey Knights (GK) 13:21 Adeptus Mechanicus (AdMech) 16:22 Istra Gilitarum (IG) 17:29 Imperial Agents  18:14 Imperial Knights 20:31 Chaos Knights 20:49 Chaos Daemons 22:13 Chaos Space Marines, Thousand Sons and World Eaters 24:06 Emperor's Children 26:26 Death Guard 28:39 Aeldari 31:21 Drukhari 33:39 Ynnari 34:23 Leagues of Votann 37:13 Tyranids 38:44 Genestealer Cults 39:11 Life Here at Poorhammer 39:47 Orks 42:01 T'au Empire 45:08 Necrons 48:21 Final Thoughts 50:38 Alright Audio Audience Our Producers for AUGUST: 3D Frank A healthy ammount of piranhas airbrush video revenue that got lost in the couch Blizted_Brain BrokenReaper45 Corvus DemolitionMann Dixie Normous Drinking vodka and playing aerial gunlance just to feel something DrLace GilgameshVS iwonderhowlongittakesbeforbloodclawsaccepttheorgys Jan Geisse Jeric Foster Kiwifruitbird Le BloupBloup mistahsquiggems Mr Festastic #WheresMikesBaneblade n0rth the H3retic Nj harlan Off topic but where's the nearest Cracker Barrel, I'm eggin for a peggin ON MAH' WAY TA' STEAL A SNAZZWAGON! Pizza00100 Ratchet7989 thatmoiety The Idiot with grey knights VictorianBatman Wargame Simulator   Our Biggest Supporters: A certain grey baneblade A Pulsating Ball of Pure Energy A Suspicious Looking Guy Addoxin Adrian Franke Aetherion Collector of Slaaneshi thighs and regret Alex Fuja amdragon Amists Andreas Another hairy Sasquatch Ava Warrior Princess Ave Dominus Nuts Bigs The Purple Necron Blubbles 180 Bob Meyers Bobqer BRB gotta snazz my wagon Canuk-eh Carnuvex Chad the Frog Christopher Gargagliano Chroma Veil Colin. H Craig Judge Crazyshak48 Cube1359 Dairy Sorceror, addicted to mana potions Daniel Field5150 Darth Vergeance DasGoopy Dominick Colacicco Dylan Baker Edward Lawrence Enchantedgalaxycat Fay FlawlessOyster Freedom is only three edibles away Gathering Clouds GearOverlord Geete Hoss Hammond How are those rivets going Eric Hyena Beans HypnoticSpecter I read the Space Wolves Codex and all I got out of it was wolfwolfwolfwolfwolfwolfwolfwolf Illindi IrisHFoXRR isaac hall J3C GAM1NG James coe Jarrett DiPerna Jolyne Justin Yudichak kalex Kaydien moore Kentorb Kozak Krishna Chanamolu L'Etranger (Lukus) Lord of Chaos LSJay Madison Ramanama Malcador the Rizzler-ite Matthew Tsushima Michael Melcher Mitchell Mixolydius mmmm burnt toast Monkey218 morfiel55 Not-Gafie NotEE Omegashark Pierce forgot about changing their name as a bit for a while Protius7331 Qelan Rock roguetraderjake RossWarlock Rothana's All Terrain Tactical Enforcer Rymora saft SarahchaSauce Shaxxs pet otter Solonite Struggle_l3us The Mailman The Other Mailman Thecrusader13 TheFishboi Thrango

✈️ In this episode of the Special Chronicles Podcast's Unified at Work Series, host Daniel Smrokowski welcomes Samantha Alloway, Executive Director of The Arc of Illinois, for an inspiring conversation about the Wings for All program. Recorded following the August 16, 2025 Wings for All event at Chicago O'Hare International Airport (ORD) in partneship with United Airlines' Bridge Disability Business Resource Group, this episode dives into: What Wings for All is and why it matters for travelers with autism and intellectual/developmental disabilities (IDD). Behind-the-scenes stories from the event at O'Hare. Heartwarming family moments, including a child who overcame fears to board an aircraft for the first time. The importance of inclusion in airports, workplaces, schools, and communities.

Join Maddy Playle, Chris Cook and Liam Headd to discuss a lively week in racing, including Arc trials' day at Longchamp on Sunday.  Last year's runner-up Aventure shot to favouritism for the French showpiece after winning the Prix Vermeille, with Whirl's defeat the second notable disappointment for the race after Kalpana's loss to Giavellotto in the September Stakes at Kempton. The team also review comments by John Gosden and Aidan O'Brien regarding Ombudsman and Delacroix in the Irish Champion Stakes, with the Ballydoyle maestro suggesting the British trainer was a sore loser after ruling out Godolphin's colt from the Group 1 clash. Finally, the panel ponder how effective Wednesday's strike action will be as racing figures prepare to gather in Westminster.

Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.”  Our full disclosures are available in the transcript of this episode.  And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%.  And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting.  So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL  for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course.  And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media:        @ASCO on X (formerly Twitter)        ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck  Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera    

Episode 182 - Every Faction's Afterlife   In this week's episode, Brad and Eric explore all the fun stuff in 40k. You know, same as last week but different. Meanwhile, Berilio quickly rushes this editing, including this text description, so he can lay down in bed and Silk his Song. Just tell Brad the edit job was good, I bet he won't test listen to know anyway.   POORHAMMER MERCH! https://orchideight.com/collections/poorhammer PATREON: https://www.patreon.com/SolelySingleton YOUTUBE: https://www.youtube.com/@thepoorhammerpodcast TWITCH: https://www.twitch.tv/poorhammer Website: https://poorhammer.libsyn.com/   RELATED TO THIS EPISODE: Every SPACE MARINE model: https://www.youtube.com/watch?v=ZO6xJGBM5lY Every AELDARI model: https://www.youtube.com/watch?v=oEnL6f1dV3Y Every ADEPTUS MECHANICUS model: https://www.youtube.com/watch?v=IkEdNsHul9E   TIMESTAMPS: 00:00 Hello and Welcome 01:05 Intro 02:56 Space Marines (SM) 07:35 Adepta Sororitas (Sisters) 11:03 Adeptus Custodes (Custodes) 12:02 Grey Knights (GK) 13:21 Adeptus Mechanicus (AdMech) 16:22 Istra Gilitarum (IG) 17:29 Imperial Agents  18:14 Imperial Knights 20:31 Chaos Knights 20:49 Chaos Daemons 22:13 Chaos Space Marines, Thousand Sons and World Eaters 24:06 Emperor's Children 26:26 Death Guard 28:39 Aeldari 31:21 Drukhari 33:39 Ynnari 34:23 Leagues of Votann 37:13 Tyranids 38:44 Genestealer Cults 39:11 Life Here at Poorhammer 39:47 Orks 42:01 T'au Empire 45:08 Necrons 48:21 Final Thoughts 50:38 Alright Audio Audience Our Producers for AUGUST: 3D Frank A healthy ammount of piranhas airbrush video revenue that got lost in the couch Blizted_Brain BrokenReaper45 Corvus DemolitionMann Dixie Normous Drinking vodka and playing aerial gunlance just to feel something DrLace GilgameshVS iwonderhowlongittakesbeforbloodclawsaccepttheorgys Jan Geisse Jeric Foster Kiwifruitbird Le BloupBloup mistahsquiggems Mr Festastic #WheresMikesBaneblade n0rth the H3retic Nj harlan Off topic but where's the nearest Cracker Barrel, I'm eggin for a peggin ON MAH' WAY TA' STEAL A SNAZZWAGON! Pizza00100 Ratchet7989 thatmoiety The Idiot with grey knights VictorianBatman Wargame Simulator   Our Biggest Supporters: A certain grey baneblade A Pulsating Ball of Pure Energy A Suspicious Looking Guy Addoxin Adrian Franke Aetherion Collector of Slaaneshi thighs and regret Alex Fuja amdragon Amists Andreas Another hairy Sasquatch Ava Warrior Princess Ave Dominus Nuts Bigs The Purple Necron Blubbles 180 Bob Meyers Bobqer BRB gotta snazz my wagon Canuk-eh Carnuvex Chad the Frog Christopher Gargagliano Chroma Veil Colin. H Craig Judge Crazyshak48 Cube1359 Dairy Sorceror, addicted to mana potions Daniel Field5150 Darth Vergeance DasGoopy Dominick Colacicco Dylan Baker Edward Lawrence Enchantedgalaxycat Fay FlawlessOyster Freedom is only three edibles away Gathering Clouds GearOverlord Geete Hoss Hammond How are those rivets going Eric Hyena Beans HypnoticSpecter I read the Space Wolves Codex and all I got out of it was wolfwolfwolfwolfwolfwolfwolfwolf Illindi IrisHFoXRR isaac hall J3C GAM1NG James coe Jarrett DiPerna Jolyne Justin Yudichak kalex Kaydien moore Kentorb Kozak Krishna Chanamolu L'Etranger (Lukus) Lord of Chaos LSJay Madison Ramanama Malcador the Rizzler-ite Matthew Tsushima Michael Melcher Mitchell Mixolydius mmmm burnt toast Monkey218 morfiel55 Not-Gafie NotEE Omegashark Pierce forgot about changing their name as a bit for a while Protius7331 Qelan Rock roguetraderjake RossWarlock Rothana's All Terrain Tactical Enforcer Rymora saft SarahchaSauce Shaxxs pet otter Solonite Struggle_l3us The Mailman The Other Mailman Thecrusader13 TheFishboi Thrango

In today's MadTech Daily, we discuss the Arc browser maker being acquired, Apple preparing a Siri search tool, OpenAI launching an AI hiring platform, and smartphones pushing streaming past linear TV in Germany.

Recopilamos canciones exclusivamente con números en sus títulos. Se trata de un bodegón sonoro magníficamente surtido y variado, comentado por Ricardo Portman. Esto va desde Prince hasta Soda Stereo. Vamos a escuchar 1999 (Prince), 1979 (The Smashing Pumpkins), 39 (Queen), 1984 (David Bowie), 19-2000 (Gorillaz), 1984 y 5150 (Van Halen), 1969 (The Stooges) y 1990 (Soda Stereo). Recuerden que nuestros programas los pueden escuchar también en: Nuestra web https://ecosdelvinilo.com/ La Música del Arcón - FM 96.9 (Buenos Aires, Argentina) miércoles 18:00 (hora Arg.) Radio M7 (Córdoba) lunes 18:00 y sábados 17:00. Distancia Radio (Córdoba) jueves y sábados 19:00 Radio Free Rock (Cartagena) viernes 18:00. Radio Hierbabuena (Lima, Perú) jueves 20:00 (hora Perú) Onda Wantuki (Madrid) semanal

https://www.youtube.com/live/t0wI68fiSA4?si=6r0JrYUQlg9AYpp0 ✈️ In this episode of the Special Chronicles Podcast's Unified at Work Series, host Daniel Smrokowski welcomes Samantha Alloway, Executive Director of The Arc of Illinois, for an inspiring conversation about the Wings for All program. Recorded following the August 16, 2025 Wings for All event at Chicago O'Hare International Airport (ORD) in partneship … Continue reading Wings for All: Flying with Heart – A Conversation with The Arc’s Samantha Alloway | Unified at Work Series S6:Pt4 The post Wings for All: Flying with Heart – A Conversation with The Arc's Samantha Alloway | Unified at Work Series S6:Pt4 first appeared on Special Chronicles.

Listen to weekly sermons from Velocity Church in Lawrence, KS. Velocity is a vision-fueled and faith-filled community changing lives and transforming a city with the message of Jesus. For more information visit www.findvelocity.org

We're kicking-off Season 20 with Arc of Infinity! This story features Time Lords doing what Time Lords do best, the return of Omega and introduction of his mutant turkey/pterodactyl thing, and some traipsing around Amsterdam. It sounds like it should be quite good. But will the Watchers think that it's the sort of bang that the season should start with – one that caused by anti-matter and matter colliding?   Join us as we discuss our total disdain for the planet Gallifrey and Time Lord society, our love of Action Hero Nyssa, the brain slugs from Futurama, how the Castellan and Commander Maxil seem to be aware of the narrative structure of a Doctor Who story, and how President Borusa is apparently very susceptible to phishing. We also delve into the question of “what is the Matrix?” – because the last time we saw it, it certainly wasn't… whatever the heck we see in this story.   If you would like to watch along with us, you can find this story available for streaming on Britbox in the USA (http://www.britbox.com) and BBC iPlayer in the UK (https://bbc.in/48GSaCB). If you're a little old fashioned and prefer physical media (like our very own Anthony), you can also find it on the Doctor Who Season 20 Blu Ray box set from Amazon US (https://amzn.to/3VyxIPe) and Amazon UK (https://amzn.to/3V2IL34)   Other media mentioned in this episode*: Blake's 7 – The Complete Collection (Amazon US: https://amzn.to/2Zh7045 | Amazon UK: https://amzn.to/39luyGI) The Tripods (Amazon US: https://amzn.to/40Omomf | Amazon UK: https://amzn.to/4ft5w8z) Tenko (Amazon US: https://amzn.to/44vCOzm | Amazon UK: https://amzn.to/3wtYY8D) Z Cars: Complete Collection One & Two (Amazon US: https://amzn.to/3pdDtmF | Amazon UK: https://amzn.to/3lV2cKn) Juliet Bravo: Series 1 (Amazon US: https://amzn.to/3GOLfyc | Amazon UK: https://amzn.to/4iZgvb9) The West Wing (Amazon US: https://amzn.to/46mlIGI | Amazon UK: https://amzn.to/465XhMC) Batman and Robin (Amazon US: https://amzn.to/3I85GHj | Amazon UK: https://amzn.to/4nhPwu3) Batman Forever (Amazon US: https://amzn.to/4n6Iok2 | Amazon UK: https://amzn.to/4miqied) Futurama – Seasons 1-8 (Amazon US: https://amzn.to/3jfbkaQ | Amazon UK: https://amzn.to/3aQeMUL) All Creatures Great and Small: The Complete Collection (Amazon US: https://amzn.to/3FpbQ1J | Amazon UK: https://amzn.to/3iC2xm9) The Great North (USA – Hulu: http://www.hulu.com | UK – Disney+: http://www.disneyplus.co.uk) Dark Souls (Amazon US: https://amzn.to/45OlkRo | Amazon UK: https://amzn.to/3K2p60K) Metroid Prime Remastered (Amazon US: https://amzn.to/4ndcWAE | Amazon UK: https://amzn.to/46msgVW) Neo Pets (https://www.neopets.com)    Finally, you can also follow us and interact with us on Facebook and Instagram. You can also e-mail us at watchers4d@gmail.com, and you can join us on our Discord server. If you're enjoying this podcast, please subscribe to the show, and leave us a rating or review.   *Support Watchers in the Fourth Dimension! We are an Amazon affiliate and earn a small commission from purchases through Amazon links. This goes towards the running costs of the podcast.

"The Art of Subtraction" | Pastor Hood | 9.7.25 by ARC of Carson City, NV

Its Saturday Its very Special and we are down a couple of members but don't worry or Arc ambassador stepped in to help us out. Listen in to see what we got into...Check us out on all social media at time for another podcast or check out our website at timeforanother.com Send us an email at timeforanotherpodcast@gmail.comSupport this podcast at — https://redcircle.com/time-for-another/exclusive-contentAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

This week we are lucky enough to be reviewing an ARC that we received by Gena Showalter and her publisher Montlake! So thank you for this opportunity to read and give our honest review.  We hope you enjoyed this episode and if you did don't forget to rate us as it helps push this podcast our to more great listeners like you! Make sure you follow us on all our socials here!

Charlotte Greenway brings you the Saturday Edition and starts by look at Saturday's Sprint Cup from Haydock with inout from trainer's Jerome Reynier and James Fanshawe on favourite Lazzat and fellow Wathnan owned Kind of Blue. Then onto France where Rosallion is looking to bag his first group 1 of the season in the Moulin and his trainer Richard Hannon explains the decision to send his colt here, having not been part of the original plan and finally Ed Walker shares his hopes for Almaqam in one of three competitive Arc trials on Sunday.

From his early days with Lodgic and World Trade, his first involvements with Yes and Chris Squire (in Conspiracy), through his solo career, many side projects (The Prog Collective, Circa, Yoso, and Arc of Life), and his eventual return to the Yes fold, Billy Sherwood has sure been around the proverbial block! Join me on […]

The Rhino in the room can't be ignored: after decades in the vault, Buckingham Nicks is finally getting a reissue. eCoustics Editors Eric Pye, Jeremy Sikora, and producer Mitch Anderson team up with mastering engineer Kevin Gray (Cohearent Audio) to dig into why this cult classic vanished, why it's back now, and what it means for fans who've been chasing scratched LPs for years. Along the way, we get into the bigger picture—the state of the reissue market, the future of vinyl cutting, and why Fleetwood Mac drama still drives the mythology around this record. Chaos may have fueled the Mac, but this one's all about clarity.Thank you to Bowers & Wilkins and SVS for their support of our programming!www.svsound.comwww.bowerswilkins.comCredits:• Original intro music by The Arc of All. https://sourceoflightandpower.bandcamp.com• Voice Over Provided by Todd Harrell of SSP Unlimited. https://sspunlimited.com• Production by Mitch Anderson, Black Circle Studios. https://blackcircleradio.comDon't forget to check our website for daily updates on the latest electronics, news, recommendations, and deals on high-end audio, loudspeakers, earphones, TVs, and more.www.ecoustics.com#fleetwoodmac #ecoustics #audiophilereissue #vinylreissue #buckinghamnicks #rhinorecords #kevingray #cohearentaudio #vinylcommunity #classicalbums #hifi #audiophile #vinylmastering #recordindustry #musicindustry

Cette semaine : Hell is Us, Hollow Knight: Silksong, 007: First Light, Qalculate!, Dia et Arc sont rachetés, Instagram dispo sur iPad, Blood Orange - Essex Honey, The Paper, et Dolby Vision 2. Lisez plutôt Torréfaction #343 : Hell is Us, Hollow Knight: Silksong, rachat Dia / Arc, Qalculate! et de la CULTURE avec sa vraie mise en page sur Geekzone. Pensez à vos rétines.

Emmet Kennedy, Andy Newton, George Gorman and Peter Michael return after another huge weekend of winners (20/1, 16/1, 14/1, 7/2, 6/4) with your betting guide to Saturday's live ITV Racing from Haydock, Ascot and Kempton.

"Search for Truth 64" | Pastor Evan Hood | 9.3.25 by ARC of Carson City, NV

Nick is joined by Rishi Persad for a look at today's racing news. With huge autumn targets around the corner, Nick talks to trainers Ed Walker and George Murphy about two talented horses that have bypassed much of the summer. Walker outlines his plans to send Almaqam to the Prix Foy this weekend en route to the Arc, and also has news of a couple of potential Breeders' Cup starters. Meanwhile, Murphy reports White Birch to be spot on for the Irish Champion Stakes next weekend. Also on today's show, Nick and Rishi reflect on Paul Nicholls's comments on the future of Champions:Full Gallop, while Charlie Brooks's Telegraph column on Summer jumping also gets some air time, as does the decision of Wimbledon Hawkeye's connections to point towards the Breeders' Cup Turf. Plus, GOFFS Joey Cullen on the 50k bonus scheme plus the success of Orby Book 2, and Klaus Eulenberger is our Weatherbys Guest, looking forward to a huge weekend in Baden-Baden, on the racecourse and in the sales arena.

Continuing in the "Seven Deadly Sins" Arc, the Movie Vault Crew (joined for the first time by Tressel) covers one of Christopher Nolan's underrated works, "The Prestige." The rivalry between the two magicians is ripe with envy. Plus we get a little magic from Nolan himself!Instagram-@TheMovieVaultPodEmail us- themovievaultpod@gmail.comYouTube - https://www.youtube.com/@lastresortnetworkThis episode is brought to you by Point A Insurance (formerly Hedman Anglin Agency). Contact them at 614-486-7300 for your home and auto insurance needs. If you do contact them, make sure to tell them that Ben and Zach sent you! Visit their website for more information at www.HedmanAnglinAgency.com

Hurinfan and Cesky discuss The Hexologists: A Tangle of Time by Josiah Bancroft, the sequel to The Hexologists. This is a SPOILER-FREE chat. Disclaimer: Green Team received an ARC of The Hexologists: A Tangle of Time by Josiah Bancroft courtesy of NetGalley and Orbit Books. We thank them for the early copy for review. All opinions are our own. The Hexologists: A Tangle of Time releases on September 9th, 2025. Hope you enjoy the episode. Music is Galactic Damages by Jingle Punks.Find us on:Discord: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://discord.gg/FNcpuuA⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BlueSky: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bsky.app/profile/greenteampod.bsky.social⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Threads:⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.threads.net/@greenteampod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Reddit: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.reddit.com/r/thelegendarium/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Suggestion Box: ⁠⁠⁠⁠⁠⁠⁠⁠https://forms.gle/Nsz6URWeq3JeeZnGA

“Sonaspection has been keeping inspectors honest since 1980—by making flaws on purpose. This week, Jeremy Ring joins me to talk NDT, mentorship, and how controlled cracks build better inspectors.”   This week on the Arc Junkies Podcast, I'm joined by Jeremy Ring, President of Sonaspection. If you're not familiar with Sonaspection, they've been training inspectors since 1980 by creating controlled flaws in real welded samples. Their work keeps inspectors sharp, welders accountable, and industries safe. Jeremy shares his journey from NASCAR engineering to NDT leadership, and we dig into how flawed specimens help inspectors build the confidence to make the right call in the field. We also talk about mentorship, the future of inspection with AI, the global shortage of inspectors, and why proper training is critical to preventing failures that could put lives at risk. If you've ever wondered how inspectors sharpen their skills—or why “known flaws” are the best teachers—this is an episode you don't want to miss.   Arc Junkies Podcast: Instagram: @Arcjunkiespodcast YouTube: https://www.youtube.com/@arcjunkiespodcast9253 Email: Show@arcjunkies.com LinkedIn: https://www.linkedin.com/in/jason-becker-45407b72?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base_contact_details%3BKipEwR3uQXCmCjaEfNzo6w%3D%3D Arc Junkies Website: https://arcjunkies.com Arc junkies Merch: https://shop.threadmob.com/arcjunkie/shop/home Underground Metal Works: https://www.underground-metalworks.com/   Friends of the Show: American Welding Society Conferences Pipeline Conference https://www.aws.org/community-and-events/conferences-and-events/pipeline/ Use ARCJUNKIES at Checkout and get a free gift at the event.   Outlaw Leather LLC Outlawleather.com Instagram: @outlawleatherusa Use ARCJUNKIES for 15% off all in-stock leather goods     Everlast Welders Instagram: @everlastwelders  YouTube: Everlast Welders         Online: https://bit.ly/37xJstI Use Codeword ARCJUNKIES at checkout to get upgraded to a free Nova Foot Pedal and TIG Torch with the purchase of any machine that comes with a stock foot pedal and TIG Torch. ISOTUNES: Instagram: @isotunesaudio Online: https://shop.isotunes.com/arcjunkies10.  Use ARCJUNKIES10 at checkout and save $10 on your purchase    

From his early days with Lodgic and World Trade, his first involvements with Yes and Chris Squire (in Conspiracy), through his solo career, many side projects (The Prog Collective, Circa, Yoso, and Arc of Life), and his eventual return to the Yes fold, Billy Sherwood has sure been around the proverbial block! Join me this week for a little tour of his vast Musical World!

In this episode of the Live United podcast, co-hosts Janey Kotthoff and Matthew Gleason sit down with Lisa Kelly, CEO of The Arc of Oklahoma, and Erin Shepherd, who leads the Arc@School program. Together, they explore how this initiative, supported by a 2023 Tulsa Area United Way Social Innovations Grant, is breaking down barriers in special education and giving families the tools they need to thrive.Learn more about the Arc of Oklahoma and Arc@School at www.thearcok.org

Emmet Kennedy is joined by Adam Mills (Total Performance Data) and racing expert Jamie Wrenn to dissect a dramatic weekend of racing across Britain, Ireland, and the USA - plus the shock news that Ryan Moore will miss the rest of the season, with Christophe Soumillon stepping in for Aidan O'Brien and Coolmore.

In this week's episode, Brad and Eric go through all the Combat Patrols released for Warhammer 10th Edition and try to figure out if it's worth the purchase… or maybe two purchases… or three. Wait… are you guys purchasing things?   POORHAMMER MERCH! https://orchideight.com/collections/poorhammer PATREON: https://www.patreon.com/SolelySingleton YOUTUBE: https://www.youtube.com/@thepoorhammerpodcast TWITCH: https://www.twitch.tv/poorhammer Website: https://poorhammer.libsyn.com/   RELATED TO THIS EPISODE: Every SPACE MARINE model: https://www.youtube.com/watch?v=ZO6xJGBM5lY Every AELDARI model: https://www.youtube.com/watch?v=oEnL6f1dV3Y Every ADEPTUS MECHANICUS model: https://www.youtube.com/watch?v=IkEdNsHul9E   TIMESTAMPS: 00:00 Intro 00:44 Episode Rules 02:53 Adepta Sororitas 06:03 Adeptus Custodes 08:57 Adeptus Mechanicus 11:40 Astra Militarum 14:38 Imperial Agents 16:41 Grey Knights 19:18 Space Marines 20:28 Black Templars 21:53 Blood Angels 23:05 Dark Angels 25:03 Space Wolves 26:23 Imperial Fists 28:01 Iron Hands 30:18 Ravenguard 31:43 Salamanders 34:09 White Scars 35:08 Chaos Daemons 36:38 Chaos Space Marines 38:04 Death Guard 39:20 Emperor's Children 41:13 Thousand Sons 43:06 World Eaters 44:14 Aeldari 46:27 Genestealer Cults 49:13 Leagues of Votann 51:04 Necrons 53:48 Orks 55:15 T'au Empire 58:14 Tyranids 01:01:31 Drukhari 01:03:50 That Does it For Us this Week 01:04:52 Alright Audio Audience   Our Producers for AUGUST: 3D Frank A healthy ammount of piranhas airbrush video revenue that got lost in the couch Blizted_Brain BrokenReaper45 Corvus DemolitionMann Dixie Normous Drinking vodka and playing aerial gunlance just to feel something DrLace GilgameshVS iwonderhowlongittakesbeforbloodclawsaccepttheorgys Jan Geisse Jeric Foster Kiwifruitbird Le BloupBloup mistahsquiggems Mr Festastic #WheresMikesBaneblade n0rth the H3retic Nj harlan Off topic but where's the nearest Cracker Barrel, I'm eggin for a peggin ON MAH' WAY TA' STEAL A SNAZZWAGON! Pizza00100 Ratchet7989 thatmoiety The Idiot with grey knights VictorianBatman Wargame Simulator   Our Biggest Supporters: A certain grey baneblade A Pulsating Ball of Pure Energy A Suspicious Looking Guy Addoxin Adrian Franke Aetherion Collector of Slaaneshi thighs and regret Alex Fuja amdragon Amists Andreas Another hairy Sasquatch Ava Warrior Princess Ave Dominus Nuts Bigs The Purple Necron Blubbles 180 Bob Meyers Bobqer BRB gotta snazz my wagon Canuk-eh Carnuvex Chad the Frog Christopher Gargagliano Chroma Veil Colin. H Craig Judge Crazyshak48 Cube1359 Dairy Sorceror, addicted to mana potions Daniel Field5150 Darth Vergeance DasGoopy Dominick Colacicco Dylan Baker Edward Lawrence Enchantedgalaxycat Fay FlawlessOyster Freedom is only three edibles away Gathering Clouds GearOverlord Geete Hoss Hammond How are those rivets going Eric Hyena Beans HypnoticSpecter I read the Space Wolves Codex and all I got out of it was wolfwolfwolfwolfwolfwolfwolfwolf Illindi IrisHFoXRR isaac hall J3C GAM1NG James coe Jarrett DiPerna Jolyne Justin Yudichak kalex Kaydien moore Kentorb Kozak Krishna Chanamolu L'Etranger (Lukus) Lord of Chaos LSJay Madison Ramanama Malcador the Rizzler-ite Matthew Tsushima Michael Melcher Mitchell Mixolydius mmmm burnt toast Monkey218 morfiel55 Not-Gafie NotEE Omegashark Pierce forgot about changing their name as a bit for a while Protius7331 Qelan Rock roguetraderjake RossWarlock Rothana's All Terrain Tactical Enforcer Rymora saft SarahchaSauce Shaxxs pet otter Solonite Struggle_l3us The Mailman The Other Mailman Thecrusader13 TheFishboi Thrango

"The Name is the Difference" | Rev. Sam Howard | 8.31.25 by ARC of Carson City, NV

On this encore Special Chronicles Podcast episode: host Daniel Smrokowski shares his keynote from the 2020 Speak Up and Speak Out Summit, presented by The Arc of Illinois and funded by the Illinois Council on Developmental Disabilities. Hear the origin story of Special Chronicles, nearly two decades of disability media storytelling, tips for creating social change, live audience Q&A, and musician Peter Leidy's song “Speak Up and Speak Out.” This episode originally aired on November 17, 2020. Episode 783 ShowNotes & Links Learn more about The Arc of Illinois' Speak Up and Speak Out Summit, a 3 day conference for people with disabilities Listen and Follow at SpecialChronicles.com/Pod

One of the hosts is back, but we're still on the lookout for Joe — if you see him, let us know! The crew kicks off the episode by recapping a fun Labor Day weekend, including catching their favorite cover band and planning to see Fisher at ARC. Then it's on to this week's hot topics: The internet's take on the Cracker Barrel logo change The launch of a women's baseball league • A local high school's bold move to remove bathroom doors • A fake relationship that totally ruins a movie And as always, we wrap things up on a positive note with Feel Good Stories.

In this week's episode, Brad and Eric go through all the Combat Patrols released for Warhammer 10th Edition and try to figure out if it's worth the purchase… or maybe two purchases… or three. Wait… are you guys purchasing things?   POORHAMMER MERCH! https://orchideight.com/collections/poorhammer PATREON: https://www.patreon.com/SolelySingleton YOUTUBE: https://www.youtube.com/@thepoorhammerpodcast TWITCH: https://www.twitch.tv/poorhammer Website: https://poorhammer.libsyn.com/   RELATED TO THIS EPISODE: Every SPACE MARINE model: https://www.youtube.com/watch?v=ZO6xJGBM5lY Every AELDARI model: https://www.youtube.com/watch?v=oEnL6f1dV3Y Every ADEPTUS MECHANICUS model: https://www.youtube.com/watch?v=IkEdNsHul9E   TIMESTAMPS: 00:00 Intro 00:44 Episode Rules 02:53 Adepta Sororitas 06:03 Adeptus Custodes 08:57 Adeptus Mechanicus 11:40 Astra Militarum 14:38 Imperial Agents 16:41 Grey Knights 19:18 Space Marines 20:28 Black Templars 21:53 Blood Angels 23:05 Dark Angels 25:03 Space Wolves 26:23 Imperial Fists 28:01 Iron Hands 30:18 Ravenguard 31:43 Salamanders 34:09 White Scars 35:08 Chaos Daemons 36:38 Chaos Space Marines 38:04 Death Guard 39:20 Emperor's Children 41:13 Thousand Sons 43:06 World Eaters 44:14 Aeldari 46:27 Genestealer Cults 49:13 Leagues of Votann 51:04 Necrons 53:48 Orks 55:15 T'au Empire 58:14 Tyranids 01:01:31 Drukhari 01:03:50 That Does it For Us this Week 01:04:52 Alright Audio Audience   Our Producers for AUGUST: 3D Frank A healthy ammount of piranhas airbrush video revenue that got lost in the couch Blizted_Brain BrokenReaper45 Corvus DemolitionMann Dixie Normous Drinking vodka and playing aerial gunlance just to feel something DrLace GilgameshVS iwonderhowlongittakesbeforbloodclawsaccepttheorgys Jan Geisse Jeric Foster Kiwifruitbird Le BloupBloup mistahsquiggems Mr Festastic #WheresMikesBaneblade n0rth the H3retic Nj harlan Off topic but where's the nearest Cracker Barrel, I'm eggin for a peggin ON MAH' WAY TA' STEAL A SNAZZWAGON! Pizza00100 Ratchet7989 thatmoiety The Idiot with grey knights VictorianBatman Wargame Simulator   Our Biggest Supporters: A certain grey baneblade A Pulsating Ball of Pure Energy A Suspicious Looking Guy Addoxin Adrian Franke Aetherion Collector of Slaaneshi thighs and regret Alex Fuja amdragon Amists Andreas Another hairy Sasquatch Ava Warrior Princess Ave Dominus Nuts Bigs The Purple Necron Blubbles 180 Bob Meyers Bobqer BRB gotta snazz my wagon Canuk-eh Carnuvex Chad the Frog Christopher Gargagliano Chroma Veil Colin. H Craig Judge Crazyshak48 Cube1359 Dairy Sorceror, addicted to mana potions Daniel Field5150 Darth Vergeance DasGoopy Dominick Colacicco Dylan Baker Edward Lawrence Enchantedgalaxycat Fay FlawlessOyster Freedom is only three edibles away Gathering Clouds GearOverlord Geete Hoss Hammond How are those rivets going Eric Hyena Beans HypnoticSpecter I read the Space Wolves Codex and all I got out of it was wolfwolfwolfwolfwolfwolfwolfwolf Illindi IrisHFoXRR isaac hall J3C GAM1NG James coe Jarrett DiPerna Jolyne Justin Yudichak kalex Kaydien moore Kentorb Kozak Krishna Chanamolu L'Etranger (Lukus) Lord of Chaos LSJay Madison Ramanama Malcador the Rizzler-ite Matthew Tsushima Michael Melcher Mitchell Mixolydius mmmm burnt toast Monkey218 morfiel55 Not-Gafie NotEE Omegashark Pierce forgot about changing their name as a bit for a while Protius7331 Qelan Rock roguetraderjake RossWarlock Rothana's All Terrain Tactical Enforcer Rymora saft SarahchaSauce Shaxxs pet otter Solonite Struggle_l3us The Mailman The Other Mailman Thecrusader13 TheFishboi Thrango

Listen to weekly sermons from Velocity Church in Lawrence, KS. Velocity is a vision-fueled and faith-filled community changing lives and transforming a city with the message of Jesus. For more information visit www.findvelocity.org

On episode 144 of "The Places Where We Go", we are taking you on a journey through the beautiful city of Paris, France. Known for its romantic charm and rich history, this city is home to some of the world's most famous museums and monuments. Our stops include the Pantheon, Musee Curie, the Arc de Triomphe, Sainte-Chapelle, the Army Museum, and the National Archives. The Places Where We Go Resources PODCAST: Released every other week in your favorite podcast app WEBSITE & BLOG www.theplaceswherewego.com SUBSCRIBE TO OUR NEWSLETTER YOUTUBE: The Places Where We Go YouTube Channel INSTAGRAM: https://www.instagram.com/theplaceswherewego TWITTER / X: https://twitter.com/theplaceswhere1 FACEBOOK: https://www.facebook.com/ThePlacesWhereWeGo EMAIL: Write to us at comments@theplaceswherewego.com GEAR WE USE: The Places Where We Go Amazon Storefront We'll see you at the places where we go. Julie & Art AFFILIATE LINK DISCLOSURE The Places Where We Go contains affiliate links and is a member of the Amazon Services LLC Associates Program. If you make a purchase using one of these Amazon links, we may receive compensation at no extra cost to you. Read our disclaimer and privacy policy for more information.

Join Brian McWilliams, John Odermatt, Lou Perez and Brian Nichols every other week for the newest show on the Lions of Liberty Network, the Politicks Podcast! And remember, they're all bloodsuckers! This week we talk about: Scottish knife / hatchet girl is famous: the new Joan of Arc? https://x.com/StefanBrakus93/status/1960308698850439384 Another Trans Catholic School Shooter https://nypost.com/2025/08/28/us-news/minneapolis-school-shooter-robin-westman-confessed-he-was-tired-of-being-trans/ Disney Looking to Make Stuff for Gen Z Men https://variety.com/2025/film/news/disney-marvel-lucasfilm-gen-z-1236494681/ Care about your liberty and future? Don't miss the Expat Money Online Summit, October 10–12, hosted by Mikkel Thorup of the Expat Money Show. It's free to attend and features top experts on protecting wealth, securing second residencies, lowering taxes, and owning property abroad. Upgrade for lifetime replay access and VIP panels with promo code LIONS for 20% off. Be sure to subscribe to the standalone Politicks Podcast feed. This is the absolute best way to support the show! Listen and subscribe on Apple Podcasts and Spotify. And remember, they're all Blood Suckers! Follow the Lions of Liberty: Twitter Rumble YouTube Instagram Telegram Get access to all of our bonus audio content, livestreams, behind-the-scenes segments and more for as little as $5 per month by joining the Lions of Liberty Pride on Patreon OR support us on Locals! Check out our merchandise at the Lions of Liberty Store for all of our awesome t-shirts, mugs and hats! Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fair is fair! We didn't start this, we didn't mean it to happen, but we're not giving up until you pay. FAIR IS FAIR!” We watched “The Legend of Billie Jean” with Jesse Krempel, the wonderful host of “Cult Cinema Circle,” and we need to make an appointment with our hairstylist. This often overlooked gem from the 1980s chronicles outlaw teens on the run from the cops, their parents, and a sleazy businessman while going “viral” in a pre-social media world. Billie Jean, played by a drop-dead gorgeous Helen Slater, and her brother Binx (teeny-teen Christian Slater - no relation) run afoul of some local dirtbags who then steal and trash Binx's prize Honda Elite scooter. The stakes are actually sort of low - but it's the principle of the matter which makes Billie Jean and company local folk heroes. In a key moment, Billie Jean chops off her hair after being inspired by Joan of Arc; she is giving us some Vidal Sassoon, Sally Hershberger realness that would make Miss Tyra Banks herself proud. The kids in this movie are so ‘80s it would make the costumers on “Stranger Things” heads spin, and the soundtrack features the absolute BANGER “Invincible” by the legendary Pat Benatar. Stay tuned for the latest Weekly Rewind at the end of the episode! Thank you for listening, and don't forget to subscribe, rate, and review us on Apple Podcasts! www.patreon.com/moviesthatmadeusgay Facebook/Instagram: @moviesthatmadeusgay Bluesky: @MTMUGPod.bsky.social Scott Youngbauer: Twitter @oscarscott / Instagram @scottyoungballer Peter Lozano: Twitter/Instagram @peterlasagna  

Geoff welcomes Luke Crawford with GA Precision to the podcast to talk about the perfect AR build for coyote hunting. They talk about all the options available on AR platform rifles and introduce the new COYOTES FEAR ME edition 22 ARC by GA Precision. Hornady: https://bit.ly/Hornady-Eastmans Kryptek: https://bit.ly/Kryptek-Eastmans Lucky Duck Predator Calls: https://bit.ly/LuckyDuck-Eastmans onX hunt: https://bit.ly/onXHunt-Eastmans SigSauer: https://bit.ly/SIGSAUER-Eastmans Silencer Central: https://bit.ly/SilencerCentral-Eastmans

Now boarding: first class, for the third episode of Zouk's Cubes! Jason Mantzoukas returns for an ATC takeover. This time, Kulap is getting the deets on how SuChin and Jason pack for an international trip. Jason is fresh off ten days in the U.K., while SuChin is prepping for her family's trip to South Korea. It's Jason's jigsaw puzzle packing vs. SuChin's clear Ziploc bags. There will be finger shoving, tarp tucking, and plenty of cubes.  We want to hear from you! Drop us a message on Speakpipe. Subscribe to the Add to Cart newsletter for juicy extras. Please note, Add To Cart contains mature themes and may not be appropriate for all listeners.  To see all products mentioned in this episode, head to @addtocartpod on Instagram. To purchase any of the products, see below.  Missed our previous Zouk's Cubes episodes? Check out ep 1 and the live show!  Trip Tarp for the tarp tuckers out there  You can never have too many totes. Jason uses the Hyperlite Tote Bag and the Tom Bihn Zip-Top Shop Bag. He also likes packable totes from Peak Design, Matador and Bellroy.  Get into these Comrad compression socks on flights  A classic cube: The Evergoods 8L Transit Packing Cube. He also loves the compression cubes from Peak Design and Nomatic.  His packable clothesline is a paracord  Adam Savage from Mythbusters makes pouches! Jason travels with the Rimowa Cabin Plus suitcase  Zouks is the backpack king!  He likes The Tom Bihn Technonaut Backpack and Shadow Guide Backpack , as well as the Arc'teryx Konseal 15 backpack  He wears the Evergoods Civic Access Sling through TSA  What's in Jason's tech bag? The Epicka Universal Travel Adapter  Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia.  Joining Lemonada Premium is a great way to support our show and get bonus content. Subscribe today at bit.ly/lemonadapremium.  Click this link for a list of current sponsors and discount codes for this show and all Lemonada shows: lemonadamedia.com/sponsorsSee omnystudio.com/listener for privacy information.