Podcasts about Vancomycin

Dhineli Perera talks to pharmacists Amy Legg and Tony Lai about their paper on the safe and effective use of vancomycin. They discuss the evolution of vancomycin therapeutic drug monitoring, including trough concentrations, and demystify AUC monitoring. They cover current recommendations, including targets for drug efficacy and safety, and priority patient groups. Read the full article by Amy, Tony, and their co-authors, in Australian Prescriber.

Show notes at pharmacyjoe.com/episode1001. In this episode, I’ll discuss the impact of compounded oral vancomycin liquid on hospital readmission for C diff infection. The post 1001: Saving Money on Oral Vancomycin Is Great For Inpatients But Can Cause Problems On Discharge appeared first on Pharmacy Joe.

On episode #73 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/16/25 – 1/29/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral AGA clinical practice guideline on the prevention and treatment of hepatitis B virus reactivation (Gastroenterology) Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients (Nature Communications) Insect-specific RNA viruses detection in Field-Caught Aedes aegypti mosquitoes from Argentina using NGS technology (PLoS Neglected Tropical Diseases) Bacterial Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis (NEJM) Impact of antibiotic treatment and predictors for subsequent infections in multidrug-resistant Pseudomonas aeruginosa catheter-associated asymptomatic bacteriuria (American Journal of Infection Control) Identification of the skip phenomenon among patients With Staphylococcus lugdunensis infective endocarditis (OFID) Emergence of infective endocarditis due to Serratia spp. (OFID) Reduction of vancomycin-associated acute kidney injury with montelukast (JID) Fungal The Last of US Season 2 (YouTube) Pulmonary co-infection of Pneumocystis jirovecii and Aspergillus species (OFID) Impact of fluconazoleon outcomes of patients with primary pulmonary coccidioidomycosis (CID) Parasitic Comparative outcomes of Babesiosis in immunocompromised and non-immunocompromised hosts (CID) Miscellaneous Hidradenitis suppurativa (LANCET) A severe case associated with mixed infections of Pasteurella multocida, Bacteroides pyogenes and Fusobacterium necrophorum due to a snow leopard bite (CMI: Clinical Microbiology and Infection) INSIDE-OUT: Introduction of speakers at IDWeek events (OFID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

TWiM explains how ticagrelor alters the membrane of S. aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance, and the development of a novel continuous disinfectant technology that decreases healthcare-associated infections in ICUs by 70%. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Become a patron of TWiM. Links for this episode Ticagrelor and S. aureus (mBio) Novel disinfectant technology (Am J Inf Control) UVC-LED to inactivate foodborne pathogens (Appl Envir Micro) UV disinfection systems (ACS Photonics) High-touch surfaces in specialized patient care area (CDC) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv  

Over 380K vancomycin treatment courses were used to evaluate the predictive performance of various vancomycin PK models across diverse age and BMI categories. Learn how to apply these findings to your patient. Full text of the Open Access manuscript is available at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.4613.

On episode #67 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 10/24 – 11/6/24. Host: Daniel Griffin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia(Nature) Bacterial Implementation of a Pharmacist-Driven Vancomycin Area Under the Concentration-Time Curve Monitoring Program Using Bayesian Modeling in Outpatient Parenteral Antimicrobial Therapy (OFID) Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin (Nature) Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureus Bacteremia or Endocarditis(CID) Fungal The Last of US Season 2 (YouTube) Notes from the Field: Trichophyton mentagrophytes Genotype VII — New York City, April–July 2024 (CDC MMWR) Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients(Transplant Infectious Disease) Parasitic Outcomes of kidney transplant recipients exposed to Chagas disease under Benznidazole prophylaxis(Transplant Infectious Disease) Fake Aristotle Fakely Rails Against Fighting Inequality (Sententiae Antiquae) Need for a paradigm shift in soil-transmitted helminthiasis control (PLoS Neglected Tropical Diseases) Miscellaneous IDSA Advocacy Results in Big Win for ID in 2025 Final Medicare Rule (IDSA) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice

On episode #66 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/8 – 10/23/24. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Prevalence of Human Papillomavirus (HPV) and HPV Type Distribution in Penile Samples in Young Men in Denmark: Results 10 Years After Implementation of a Girls-Only HPV Vaccination Program (JID) Primary Care Guidance for Providers of Care for Persons With Human Immunodeficiency Virus: 2024 Update by the HIV Medicine Association of the Infectious Diseases Society of America (CID) Bacterial Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation (LANCET: Infectious Diseases) Time to turn off the toxins: adjuvant suppression of group A streptococcus (LANCET: Infectious Diseases) Comparing rates of recurrent infection for first occurrence of Clostridioides difficile between tapered oral vancomycin and standard vancomycin: a retrospective, propensity matched cohort study(Infection Control and Hospital Epidemiology) Evaluation of primary oral vancomycin prophylaxis against C. difficile infection during autologous stem cell transplantation (OFID) Oral Vancomycin to Prevent C. difficile in Stem Cell Transplant Recipients: The last frontier in antimicrobial prophylaxis (OFID) First Report of a Fatal Septicemia Case Caused by Vibrio metoecus: A Comprehensive Functional and Genomic Study (JID) Fungal The Last of US Season 2 (YouTube) A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group(PLoS Neglected Tropical Diseases) Epidemiological and clinical features of a large blastomycosis outbreak at a paper mill in Michigan (CID) Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris? (PLoS Pathogens) Parasitic Beyond Human Babesiosis: Prevalence and Association of Babesia Coinfection with Mortality in the United States, 2015–2022: A Retrospective Cohort Study (OFID) New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine (LANCET: Infectious Diseases) Miscellaneous Social and Environmental Benefitsof Pediatric Infectious Disease Telemedicine (Journal of the Pediatric Infectious Diseases Society) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Enterococci are commensal microbes, part of the healthy microflora populating the human gut. But they are also opportunistic pathogens and notorious nosocomial agents with intrinsic traits that promote their pathogenesis and make them difficult to kill. In the third instalment of the Nightmare Series, hosts Angela Huttner and Thomas Tängdén are joined by enterococcal experts Kimberly Kline (University of Geneva) and Louis Rice (Brown University) to discuss what make vancomycin-resistant enterococci, or VRE, such a clinical nightmare. Enterococcus faecalis and Enterococcus faecium are the focus. This episode was edited by Kathryn Hostettler and peer-reviewed by Dr. Nunzia Esposito of the University of Naples Federico II, Naples, Italy. Literature  Stellfox ME et al. J Antimicrob Chemother 14 Feb 2024. doi: 10.1128/mbio.03396-23  Rogers R & Rice LB. Clin Infect Dis 15 Jan 2024. doi: 10.1093/cid/ciad613 Lebreton F et al. Cell 18 May 2017. doi: 10.1016/j.cell.2017.04.027 Donskey CJ et al. N Engl J Med 28 Dec 2000. doi: 10.1056/NEJM200012283432604

Free book is here at https://www.memorizingpharm.com/books Summary 3.20 Vancomycin  The chapter covers vancomycin, a glycopeptide antibiotic used for treating serious infections like MRSA. It works by inhibiting bacterial cell wall synthesis. Vancomycin is typically administered via IV for systemic infections and orally for C-diff. Key concerns include nephrotoxicity, ototoxicity, and "red man syndrome," which occurs with rapid infusion. Monitoring of renal function and trough levels is crucial. Multiple Choice Questions What is vancomycin primarily used to treat? a) Viral infections b) MRSA c) Fungal infections d) Diabetes How does vancomycin work? a) Disrupts protein synthesis b) Inhibits cell wall synthesis c) Increases glucose uptake d) Enhances DNA replication What condition can occur if vancomycin is infused too quickly? a) Hair loss b) Red man syndrome c) Weight gain d) Increased appetite How is vancomycin administered for systemic infections? a) Orally b) Topically c) Intravenously d) Subcutaneously Which function should be closely monitored during vancomycin therapy? a) Cardiac function b) Renal function c) Respiratory function d) Blood glucose levels Answer Key b) MRSA b) Inhibits cell wall synthesis b) Red man syndrome c) Intravenously b) Renal function

Show notes at pharmacyjoe.com/episode956. In this episode, I'll discuss the possibility of vancomycin treatment failure with old CVVHDF dosing regimens. The post 956: Beware of vancomycin treatment failure with old CVVHDF dosing regimens appeared first on Pharmacy Joe.

Pharmacotherapy specialist Kristin Zeitler, PharmD, from Tampa General Hospital in Tampa, FL, presents this talk on the basics of antimicrobial therapy management for hospital patients. Dr. Zeitler begins by emphasizing the important of the ID clinical pharmacist. She then compares and contrasts Pharmacokinetics (PK) , the way drugs move through the body, with Pharmacodynamics (PD), the relationship between serum drug concentration and the therapeutic/toxic effects of the drug. PK/PD effects of antimicrobials are then further explored. Dr. Zeitler goes on to discuss Vancomycin dosing strategies, the effects of serum albumin on serum antimicrobial drug levels, drug penetration into the site of interest, drug dosing strategies for patients with renal insufficiency, and the effects of obesity and critical illness on antimicrobial dosing strategies.

On episode #56 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/28 – 6/5/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Highly pathogenic H5N1 in US dairy cattle and 2 human cases (MMWR) Developing novel treatments for acute COVID-19 should address long COVID (JID) Reactivation of inherited HHV 6B in transplant recipient (JID) Bacterial Suppressive antibiotic therapy after DAIR for acute periprosthetic joint infections (OFID) Piperacillin-tazobactam vs cefepime for sepsis treatment (JAMA Internal Medicine) Are the new diagnostic algorithms for pulmonary tuberculosis more sensitive? (OFID) Social factors associated with congenital syphilis (CID) Oral vancomyin treatment influences Clostridioides difficile recurrence in patients on concurrent systemic antibiotics Association between infectious diseases consultation and morality in Gram negative infected patients (CID) Fungal Not washing your hands: fluconazole-resistant Candida parapsilosis epidemiology (OFID) Retrospective case series: how Candida auris blood infections effect left ventricular assist devices (OFID) Trichophyton indotineae: clinical course, suspectibility and genome sequence (JAMA Dermatology) Screening serum for cryptococcal antigen in liver transplant recipients (OFID) Parasitic US outbreak of human trichinellosis (MMWR) Plague-ing the Pawlowsky glands of human body lice and transmission by bite(PLoS Biology) Miscellaneous Global change drivers and risk of infectious disease (Nature) ID specialists should care about ventilation (CMI) Music is by Ronald Jenkees

Episode Notes The Society of Infectious Diseases Pharmacists is excited to invite you to the first ever meeting (via Breakpoints) of The Tortured Stewards & Surgeons Department. Today's agenda items: optimal management of perioperative antibiotics and prevention of surgical site infections. Drs. Trisha Peel (@DrTrishaPeel), Michael Calderwood (@CalderwoodMD) and Patch Dellinger join Dr. Jillian Hayes (@thejillianhayes) to discuss some of the controversies we encounter while managing antibiotics in the perioperative space. Does anyone really need post-op antimicrobial prophylaxis longer than 24 hours? Where should vancomycin be fitting into surgical prophylaxis regimens? Can we truly give pre-operative cefazolin to patients with a penicillin allergy? Tune in for the answers to these questions and more! Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About X: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp If you'd like more information about the CALIPSO trial, please visit this link: https://www.anzca.edu.au/profiles/ctn-trials/underway/calipso Bibliography SSI Infection Prevention Review: https://jamanetwork.com/journals/jama/article-abstract/2800424#:~:text=Six%20are%20supported%20by%20randomized,use%20a%20chlorhexidine%20gluconate%2Dalcoho Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update: https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/strategies-to-prevent-surgical-site-infections-in-acutecare-hospitals-2022-update/2F824B9ADD6066B29F89C8A2A127A9D American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update: https://journals.lww.com/journalacs/citation/2017/01000/american_college_of_surgeons_and_surgical.8.aspx  2017 CDC Guidelines: https://jamanetwork.com/journals/jamasurgery/fullarticle/2623725  2018 WHO Guidelines: https://arthroplasty.biomedcentral.com/articles/10.1186/s42836-022-00113-y  ASHP Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery: https://www.ashp.org/surgical-guidelines  Surgeons as Stewards: https://journals.lww.com/journalacs/citation/2020/12000/perioperative_antibiotic_prophylaxis__surgeons_as.23.aspx  Li et al, Arthroplasty 2022: https://arthroplasty.biomedcentral.com/articles/10.1186/s42836-022-00113-y  Dutch Arthroplasty Register Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023957/  de Jonge Meta-Analysis on duration and incidence of SSI: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30084-0/abstract  Prolonged Antibiotic Prophylaxis After Cardiovascular Surgery and Its Effect on Surgical Site Infections and Antimicrobial Resistance: https://www.ahajournals.org/doi/10.1161/01.cir.101.25.2916?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed RCT - Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs: https://jamanetwork.com/journals/jama/article-abstract/2810510  NYU Langone Study - Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin Ointment and Nasal Povidone-Iodine Solution: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=91dee3e1445adb80d533f2c210816a3285254e3a  Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty: https://www.nejm.org/doi/full/10.1056/NEJMoa2301401 What Is the Primary Driver of Preoperative Vancomycin Use? It's Not Methicillin-resistant Staphylococcus aureus—or Allergy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744972/  Drug allergy: a 2022 practice parameter update: https://www.jacionline.org/article/S0091-6749(22)01186-1/fulltext  Perioperative use of cefazolin without preliminary skin testing in patients with reported penicillin allergy: https://www.surgjournal.com/article/S0039-6060(18)30307-6/abstract#%20  Timing of Surgical Prophylaxis RCT: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(17)30176-7/abstract  Propensity Score-Weighted Analysis of Postoperative Infection in Patients With and Without Preoperative Urine Culture: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2815528

Episode 162: Early-Onset Sepsis      Dr. Kooner explains how to diagnose early-onset sepsis by using clinical evaluation and clinical tools. Dr. Schlaerths describes the signs and symptoms of sepsis in neonates, and Dr. Arreaza adds comments about GBS bacteriuria.  Written by Lovedip Kooner, MD, editing Hector Arreaza, MD, and comments by Katherine Schlaerth, MD. Rio Bravo Family Medicine Residency Program.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction:Neonatal sepsis is defined as pathogenic bacterial growth from blood or cerebral spinal fluid culture within the first 28 days of life. Neonatal sepsis can be divided into two categories: early-onset sepsis (EOS) and late-onset.  EOS is neonatal sepsis within 72 hours or 7 days after birth, depending on the specialist. How common is early-onset sepsis (EOS)?According to the CDC, the infant mortality rate rose for the first time in 20 years in the USA. In the U.S., the incidence of EOS is 0.5 in 1,000 live births and carries a mortality rate of about 3%. What causes EOS?Most infections are due to ascending lower vaginal tract flora. Other causes include intra-amniotic infections and maternal hematogenous spread of systemic infections. Group B streptococcus (S. agalactiae) accounts for about 1/3 of the infectious organisms, followed by E. coli which accounts for about 1/4, and Viridans streptococci account for about 1/5 of infections. Cases of E. coli are seen more often with prolonged rupture of membranes and intrapartum antibiotic exposure. Other notable infections are Listeria monocytogenes, coagulase-negative staphylococci (CoNS), herpes simplex virus, and enteroviruses. The role of GBS.Approximately 30% of women have vaginal and rectal GBS colonization and 50% will transmit it to the newborn. Without maternal antibiotic treatment, 1-2% of those infants will develop EOS. The American College of Obstetricians and Gynecologists (ACOG) recommends universal culture-based screening for GBS at 36-37 weeks and 6 days regardless of mode of delivery. GBS bacteriuria: Treat it (symptomatic and asymptomatic) if >105 CFU/mL. Do not treat it in asymptomatic patients if GBS 18 hours, intrapartum fever, or GBS positive in previous pregnancy.Nucleic acid amplification test: NAAT in pregnancy is not recommended to determine colonization status. However, if NAAT is obtained in the intrapartum period, give IAP if positive. But, you must also give IAP if negative + mentioned risk factors (18h, Maternal fever >100.4F)What is considered adequate intrapartum antibiotic prophylaxis? Penicillin and ampicillin are the recommended antibiotics for prophylaxis. Cefazolin can be given if there is a penicillin-allergy with a low risk for anaphylaxis. Clindamycin and vancomycin are reserved for cases of maternal penicillin allergy. Specifically, clindamycin can be used only if GBS is known to be sensitive to clindamycin. Vancomycin must be used if GBS is resistant to clindamycin. Do not use erythromycin. You will Administered at least 4 hours before delivery.IAP is believed to reduce neonatal GBS disease by: (1) temporarily reducing maternal vaginal GBS colonization; (2) preventing colonization of the fetus or newborn's surfaces and mucous membranes; and (3) achieving antibiotic levels in the newborn's bloodstream sufficient to surpass the minimum inhibitory concentration (MIC) for eliminating group B streptococci.Diagnosis of EOS:Clinical presentation: Tachycardia, tachypnea, temperature instability, supplemental oxygen requirement, and lethargy. Hypoglycemia should not be considered a sign of EOS.Diagnosing early-onset sepsis is achieved through blood or cerebrospinal fluid (CSF) cultures. Not effective methods for diagnosing EOS include laboratory tests, such as a complete blood cell count or C-reactive protein (CRP), as well as surface cultures, gastric aspirate analysis, or urine culture.Most infants will generally show signs of EOS GBS infection within the initial 24 hours of birth, with approximately 85% exhibiting symptoms during this timeframe.Waiting for cultures and/or signs can delay lifesaving treatment.Management:According to the American Academy of Pediatrics (AAP), the management of term and late-term infants is undertaken via the clinical condition assessment, the categorical risk factor assessment, and the multivariate risk assessment. As a part of the 2015 AAP guidelines, the Categorical Risk Factor Assessment is more of an algorithmic approach based on the presence or absence of specific risk factor threshold values such as:Ill-appearing infant. Mother diagnosed with chorioamnionitis.Mother GBS positive with inadequate intrapartum prophylaxis.ROM >18 hours.Birth before 37 weeks of gestation.Antibiotics are not always needed, and they can even cause damage. Information taken from the American Academy of Pediatrics, “Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis,” published on December 1, 2018:(1) Any newborn infant who is ill-appearing or (2) when the mother has a clinical diagnosis of chorioamnionitis -> laboratory testing must be ordered, and empirical antibiotic therapy should be started.(3) A mother who is colonized with GBS and who received inadequate intrapartum antibiotic prophylaxis, with a duration of ROM being >18 hours or birth before 37 weeks' gestation -> laboratory testing should be ordered.(4) A mother who is colonized with GBS who received inadequate IAP but with no additional risk factors -> observation in the hospital for ≥48 hours.______________________________Conclusion: Now we conclude episode number 162, “Early-onset Sepsis Introduction.” Dr Kooner explained the role of GBS in the pathophysiology of EOS, Dr. Schlaerth discussed the importance of clinical evaluation and Dr. Arreaza explained that GBS screening in the third trimester is not needed when there is a GBS positive urine culture early in pregnancy. Don't miss part 2 of this discussion. By the way, we do not recommend using feces to prevent or treat sepsis, we just shared anecdotal information to end with a funny note.This week we thank Hector Arreaza, Lovedip Kooner, and Katherine Schlaerth. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Neonatal Early-Onset Sepsis Calculator by Kaiser Permanente, available at: https://neonatalsepsiscalculator.kaiserpermanente.org/.Espinosa K, Brown SR. Neonatal Early-Onset Sepsis Calculator. Am Fam Physician. 2021;104(6):636-637.https://www.aafp.org/pubs/afp/issues/2021/1200/p636.html.Puopolo KM, Benitz WE, Zaoutis TE; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES. Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6):e20182894. doi: 10.1542/peds.2018-2894. PMID: 30455342. https://pubmed.ncbi.nlm.nih.gov/30455342/.Briggs-Steinberg C, Roth P. Early-Onset Sepsis in Newborns. Pediatr Rev. 2023 Jan 1;44(1):14-22. doi: 10.1542/pir.2020-001164. PMID: 36587021. https://pubmed.ncbi.nlm.nih.gov/36587021/.Flannery DD, Puopolo KM. Neonatal Early-Onset Sepsis. Neoreviews. 2022 Nov 1;23(11):756-770. doi: 10.1542/neo.23-10-e756. PMID: 36316253. https://pubmed.ncbi.nlm.nih.gov/36316253/.Polin RA; Committee on Fetus and Newborn. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012 May;129(5):1006-15. doi: 10.1542/peds.2012-0541. Epub 2012 Apr 30. PMID: 22547779. https://pubmed.ncbi.nlm.nih.gov/22547779/.Royalty-free music used for this episode: Good Vibes_Adventure Time by Simon Pettersson, downloaded on July 20, 2023, from https://www.videvo.net/  

Today's episode of The SHEA Podcast discusses vancomycin and how antimicrobial stewardship programs should address its use. Our moderator is Mackenzie Keintz and our guests are Rebekah Moehring and Kimberly Claeys, two experts on the topic that represent the physician and pharmacy perspective of ASP programs. Listen as they discuss why vancomycin is a target for antimicrobial stewardship programs, strategies to target vancomycin use and safety, available alternatives, how to work with over prescribers, and lessons learned from our guests experiences targeting vancomycin use at their institution.

Show notes at pharmacyjoe.com/episode885. In this episode, I ll discuss whether it is ever appropriate for a patient to be on oral and IV vancomycin. The post 885: Don’t Automatically Assume This When Oral Vancomycin is Prescribed appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode885. In this episode, I'll discuss whether it is ever appropriate for a patient to be on oral and IV vancomycin. The post 885: Don’t Automatically Assume This When Oral Vancomycin is Prescribed appeared first on Pharmacy Joe.

On episode #44 of the Infectious Disease Puscast, Sara reviews the infectious disease literature for the weeks of 12/8 – 12/20/23. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Mpox and chickenpox co-infection (J Inf Dis) Corticosteroids for postherpetic neuralgia (Coch Data Syst Rev) Dengue incidence and mortality in Bangladesh (J Inf Dis) ACORN trial vancomycin and piperacillin-tazobactam (Open For Inf Dis) Models for infection risk in children with cancer (J Clin Oncol) Salmonella outbreak from cantaloupes (CDC) Pediatric antimicrobial stewardship programs ( Ped Inf Dis Soc) MRSA nasal swab PCR assay (J Ped Inf Dis Soc) Invasive meningococcal disease (Open For Inf Dis) Probiotics for recurrent UTI (Clin Inf Dis) Preservation fluid contamination and kidney transplant patients (Transpl Inf Dis) Mechanism of zinc prevention of candidiasis (Sci Transl Med) Risk factors for invasive fungal infection (Open For Inf Dis) Genetic variants associated with S. mansoni worm burden (PLoS NTD) Chagas disease GI manifestations (Am J Trop Med Hyg) Wolbachia in Aedes aegypti in Colombia (PLoS NTD) Music is by Ronald Jenkees

Join Dr. Kiltz and special guest Britton Kelley for a captivating conversation on transforming your life, finding your motivation, and inspiring others to become their best selves through improved daily habits and choices.  Britton Kelley is the founder of:  -BKCrew (Fitness and nutritional life stylist)  -The 5 Day Fat Adaptation Plan  -Modified Carnivore Omad Lifestyle  Britton has been a strength and conditioning specialist over the last 3 decades. His clients range from professional athletes across multiple different teams to Hollywood actors throughout the world.  Britton's work has had an extreme impact on the NBA and many of its players.    After a near-death experience in 2022, it was declared that he would probably never walk again and would be reliant on the all-so-powerful Vancomycin antibiotic for the rest of his life.  Through the power of determination, he was able to heal himself through nutrition and come off of all medicines , regain full mobility of his legs and resume daily functions. He has made it his life's passion to help people worldwide heal their mind and body through the choices they make daily.    Britton has obtained multiple training certifications ranging from NASM certified fitness specialist to RTS resistance training specialist program. He studied Nutrition and Wellness at Black Hills State University where he also started as a defensive linebacker.  Hailing from New York, Britton is on a relentless mission to impact the world with his Modified Carnivore and OMAD approach to life.    In this episode you will discover:   The “modified carnivore” diet  Motivation for change  Building the right fitness routine for you  Living your dream life  Thoughts on inspiring others    Connect with Britton:   Instagram  YouTube  Website    Connect more with Dr. Kiltz:  Website  Kiltz Mighty Tribe - Free membership and 30-Day Course   Doctor Kiltz Nutritional Solutions  Instagram  Tiktok  Facebook  Amazon   

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Vancomycin⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

On episode #40 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/13 – 10/25/23. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Sustained viral suppression with dolutegravir monotherapy over 192 weeks in patients starting combination antiretroviral therapy during primary HIV infection (CID) Dolutegravir monotherapy possibly boosted by highly active natural immunity (CID) Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet) Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis (JID) Adjunctive dexamethasone for tuberculous meningitis in HIV-positive adults (NEJM) Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection (JAMA) Acute kidney injury with empirical antibiotics for sepsis (JAMA) Mycobacterium abscessus outbreak related to contaminated water among  ventilator-dependent residents of a pediatric facility (CDC) Trial of Vancomycin and Cefazolin as surgical prophylaxis in arthroplasty (NEJM) Trimethoprim-sulfamethoxazole significantly reduces the risk of nocardiosis in solid organ transplant recipients (CMI) Risk of hematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals (CMI) In vitro susceptibility patterns for slowly growing non-tuberculous mycobacteria (JAC) Real-world use of mold-active triazole prophylaxis in the prevention of invasive fungal diseases (OFID) Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 (INI) Real-time dermoscopy of numerous mites crawling on the crusted scabies (CMI) The African eye worm: current understanding of the epidemiology, clinical disease, and treatment of loiasis (The Lancet) Decolonization in nursing homes to prevent infection and hospitalization (NEJM) Can chatbot artificial intelligence replace ID physicians in the management of bloodstream infections (CID) Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in ICUs (JAMA) FDA Approves PENBRAYATM for the prevention of the five most common serogroups causing meningococcal disease in adolescents (Pfizer) Music is by Ronald Jenkees

Contributor: Meghan Hurley MD Educational Pearls: What is Cellulitis? A common and potentially serious bacterial skin infection. Caused by various types of bacteria, with Streptococcus and Staphylococcus species being the most common. What is Preseptal Cellulitis and why is it more serious than facial cellulitis? Preseptal Cellulitis, also known as Periorbital Cellulitis, is a bacterial infection of the soft tissues in the eyelid and the surrounding area. This requires prompt and aggressive treatment to avoid progression into Orbital Cellulitis. How is Preseptal Cellulitis treated? Oral antibiotics for five to seven days. In the setting of trauma (scratching bug bites) Clindamycin or TMP-SMX (for MRSA coverage) and Amoxicillin-clavulanic acid or Cefpodoxime or Cefdinir. If there is no trauma, monotherapy with amoxicillin-clavulanic acid is appropriate. Check immunization status against H.influenzae and adjust appropriately. What is Orbital Cellulitis, how is it diagnosed, and why is it more serious than Preseptal Cellulitis? Orbital cellulitis involves the tissues behind the eyeball and within the eye socket itself. Key features include: Eye pain. Proptosis (Bulging of the eye out of its normal position). Impaired eye movement. Blurred or double vision. This can lead to three very serious complications: Orbital Compartment Syndrome. This can push eye forward, stretch optic nerve, and threaten vision. Meningitis given that the meninges of the brain are continuous with optic nerve. Endophthalmitis, which is inflammation of the inner coats of the eye. This can also threaten vision. If suspected, get a CT of the orbits and/or an MRI to look for an abscess behind the eyes. How is Orbital Cellulitis treated? IV antibiotics. Cover for meningitis with Ceftriaxone and Vancomycin. Add Metronidazole until intracranial involvement has been ruled out. Drain the abscess surgically. Usually this is performed by an ophthalmologist or an otolaryngologist. Admit to the hospital. References Bae C, Bourget D. Periorbital Cellulitis. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29261970. Chaudhry IA, Shamsi FA, Elzaridi E, Al-Rashed W, Al-Amri A, Al-Anezi F, Arat YO, Holck DE. Outcome of treated orbital cellulitis in a tertiary eye care center in the middle East. Ophthalmology. 2007 Feb;114(2):345-54. doi: 10.1016/j.ophtha.2006.07.059. PMID: 17270683. Seltz LB, Smith J, Durairaj VD, Enzenauer R, Todd J. Microbiology and antibiotic management of orbital cellulitis. Pediatrics. 2011 Mar;127(3):e566-72. doi: 10.1542/peds.2010-2117. Epub 2011 Feb 14. PMID: 21321025. Wong SJ, Levi J. Management of pediatric orbital cellulitis: A systematic review. Int J Pediatr Otorhinolaryngol. 2018 Jul;110:123-129. doi: 10.1016/j.ijporl.2018.05.006. Epub 2018 May 8. PMID: 29859573. Summarized by Jeffrey Olson MS2 | Edited by Meg Joyce & Jorge Chalit, OMSII  

Time to "idiot proof" the myth of bactericidal being better than bacteriostatic agents onthis collaborative episode with the ID_IOTS podcast.About our Guest: Jame and Callum are the hosts of the ID_IOTS podcast, an Infectious Disease podcast. You can find them through https://idiotspodcasting.buzzsprout.com/share wherever you get your podcasts and also on Twitter as @IDiots_pod References from this episode: https://idiotspodcasting.buzzsprout.com/1782416/12537247-44-the-basics-of-beta-lactamase-inhibitorsWald-Dickler N, Holtom P, Spellberg B. Busting the Myth of ‘Static vs Cidal': A Systemic Literature Review. Clin Infect Dis. 2018 17;66(9):1470–4.Use of bacteriostatic agents in Neutropenic fever: DOI: 10.1586/eri.09.11. Jaksic B, Martinelli G, Oteyza JP, Hartman CS, Leonard LB, Tack KJ. Efficacy and Safety of Linezolid Compared with Vancomycin in a Randomized, Double-Blind Study of Febrile Neutropenic Patients with Cancer.Clinical Infectious Diseases. 2006 Mar 1;42(5):597–607https://www.bradspellberg.com/shorter-is-better Visit the Microbe Mail website to sign up for updates E-mail: mail.microbe@gmail.comYouTube: Microbe MailInstagram: Microbe_Mail

Dr. Kristen Zeitler, a pharmacist and pharmacotherapy specialist at Tampa General Hospital, discusses basic information about how to properly dose antimicrobial agents in hospital patients. Dr. Zietler begins by discussing the role that ID clinical pharmacist play in hospitals. She then compares and contrasts the differences between pharmacokinetics (PK) and pharmacodynamics (PD). The principles of pharmacokinetics are then covered, with regard to absorption, distribution, metabolism, and elimination. Next, PK/PD concepts are explored, especially as it relates to Vancomycin. Lastly, adjustment of dosing in renal insufficiency or dialysis is explored.

In this podcast, Dr. Meredith Oliver and Dr. Lizbeth Hansen discuss the AJHP Descriptive Report, “Considerations for implementation of vancomycin Bayesian software monitoring in a level IV NICU population within a multisite health system,” with host and AJHP Editor in Chief Dr. Daniel Cobaugh. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

Show notes at pharmacyjoe.com/episode797. In this episode, I’ll discuss empiric dosing of vancomycin for patients on CRRT. The post 797: What is a good empiric dose of vancomycin for patients on CRRT? appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode797. In this episode, I’ll discuss empiric dosing of vancomycin for patients on CRRT. The post 797: What is a good empiric dose of vancomycin for patients on CRRT? appeared first on Pharmacy Joe.

2023 SCCM PharmD Star Researchers 03:10 – Restrictive Resuscitation in Patients with Sepsis: A Systematic Review with Trial Sequential analysis with Sylvia Stefanos, PharmD  10:50 – Incidence of Acute Kidney Injury in Traumatic Brain Injury Patients Treated with Hypertonic Saline with Jesse Briscoe, PharmD 19:42 – Comparison of Factor Products for Uncontrolled Bleeding Related to Cardiac Surgery with Lauren Caldwell, PharmD, BCCCP 28:00 – Validation of Heparin-Induced Thrombocytopenia Risk Stratification Tools in Post-Surgical Cardiovascular Patients with Shahristan Kokoy, PharmD, BCPS 39:16 – Naloxone Co-prescribing for Emergency Medicine and Trauma Patients at High-risk for Opioid Overdose with William Peppard, PharmD, BCPS, FCCM 52:20 – Incidence of Detectable Drug Levels with Inhaled Aminoglycoside Therapy in Critically Ill Adults with Jenny Schultheis, PharmD, BCPS, BCCCP 63:28 – Evaluation of Achieving Targeted Vancomycin Levels in Augmented Renal Clearance with Sydney Wilson, PharmD 73:30 – Vancomycin and Piperacillin/tazobactam or Cefepime and Sepsis-Associated AKI Trajectory with Michael Behal, PharmD, BCCCP PharmacyToDose.Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Generic Name vancomycin Trade Name Vancocin Indication life threatening infections, sepsis Action bactericidal, inhibits cell wall synthesis Therapeutic Class anti-infectives Pharmacologic Class glycopeptides Nursing Considerations • can cause ototoxicity, nausea, vomiting, nephrotoxicity, anaphylaxis, red-man syndrome • assess for infection • obtain culture prior to initiating therapy • monitor blood pressure • dose dependent draw serum trough levels frequently • administer over at least 60 minutes to avoid skin irritation

Show notes at pharmacyjoe.com/episode788. In this episode, I'll discuss persistent MRSA bacteremia after vancomycin therapy. The post 788: Persistent MRSA bacteremia after vancomycin therapy appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode788. In this episode, I ll discuss persistent MRSA bacteremia after vancomycin therapy. The post 788: Persistent MRSA bacteremia after vancomycin therapy appeared first on Pharmacy Joe.

Host Dr. Paul Whiting interviews paper author Dr. William Obremskey as they discuss this 10 year study outcome relative to infection rates with Vancomycin and analyzing and interpreting the data using Bayesian analysis. This paper was presented at the 2022 OTA Annual Meeting. For additional educational resources visit https://ota.org/ To see the abstract while you listen, as well as explore OTA CME podcast episodes, download the ConveyMED App for free: Apple Store click here  Google Play click here

Show notes at pharmacyjoe.com/episode775. In this episode, I'll discuss a web-based program to estimate vancomycin AUC from a single trough value. The post 775: A web-based program to estimate vancomycin AUC from a single trough value appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode775. In this episode, I ll discuss a web-based program to estimate vancomycin AUC from a single trough value. The post 775: A web-based program to estimate vancomycin AUC from a single trough value appeared first on Pharmacy Joe.

On episode #15 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 10/27/22 – 9/9/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Clinical presentation and severity of adenovirus detection alone vs adenovirus co-detection with other respiratory viruses in US children (JPID) Effectiveness of different antimicrobial strategies for staphylococcal prosthetic joint infection (OFID) Clinical impact of ceftriaxone resistance in E. coli bloodstream infections (OFID)  Adjunctive Gentamicin and Rifampin in staphylococcal prosthetic valve Endocarditis (OFID) Diagnostic performance of physician gestalt for bacteremia in patients in the process of being admitted with suspected infection (OFID) Effectiveness of quinolone prophylaxis in pediatric acute leukemia and hematopoietic stem cell transplantation (OFID) Risk factors for Vancomycin drug reaction with Eosinophilia and Systemic symptoms syndrome (JAMA) Prospective evaluation of the fungitell 1>3 beta-d-glucan assay as a diagnostic tool for invasive fungal disease (Wiley) Safety and efficacy of a monoclonal antibody against malaria in Mali (NEJM) Hospitalizations associated with strongyloidiasis in the United States (CID)  Prophylactic benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs (PLOS NTD) Baker's dozen of top antimicrobial stewardship intervention publications for hospitalized patients (OFID) Baker's dozen of top antimicrobial stewardship intervention publications in non-hospital care settings in 2021 (OFID) Medical student debt and the US ID workforce (CID) Music is by Ronald Jenkees

The Filtrate:Joel TopfSwapnil HiremathNayan AroraPriya YenebereSpecial Guests:Todd Miano, PharmD, PhD @Miano81 Assistant Professor of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine.Show Notes:Early Pip/Tazo article showing nephrotoxicity. Covered by NephJCLinazolid vs Vanco RCT showing excess AKI with Vanco. Yes Vance is a lot less toxic than it was in the Mississippi mud days but your attending telling you it is no longer nephrotoxic is wrong. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study and Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis.Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum CreatinineVancomycin-Associated Cast Nephropathy: Reality or Fantasy?Molecular Epidemiology of SepsiS in the ICU (MESSI) prospective cohort. Learn about it her: A multibiomarker-based outcome risk stratification model for adult septic shock*Cystatin C in acute kidney injury Changing Definitions of SepsisProposed new definitions of AKI incorporating biomarkers: Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference. A Consensus Statement in JAMA Network OpenApplications of propensity score methods in observational comparative effectiveness and safety research: where have we come and where should we go?The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort studyProtective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animalsPulmCrit – Myth-busting the conditional nephrotoxicity of piperacillin-tazobactam by Josh FarkasSharp Objects on Good ReadsBandon Dunes The Ocean Course at Kiawah Island Golf ResortBe Real follow me: BeRe.al/kidney_boySNL spoof of BeReal

On episode #8 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 7/21/22 – 8/3/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Pediatric hepatitis linked to infection with two viruses (BMJ)  Protection duration of Yellow Fever vaccination (CID) Impact of CSF panel on duration of treatment (OFID) Cluster of Parechovirus infections in infants (MMWR) Molecular ecology and risk factors for Escherichia coli (Journal of Antimicrobial Therapy)  Melioidosis endemic in areas of the Mississippi gulf coast (CDC) Early switch from intravenous to oral antibiotics in infections (OFID) Duration of therapy and the use of Quinolone/Rifampin-Based regimens for joint infections (OFID) Efficacy of Doxycycline for mild-to-moderate community-acquired Pneumonia in adults (CID) Effectiveness of a Vancomycin dosing protocol (Cambridge Core) Outcomes of Fungemia in patients receiving extracorporeal membrane oxygenation (IDSA)  Malaria transmission intensity likely modifies RTS, S/AS01 efficacy (IDSA) Ultrashort course antibiotics for suspected pneumonia (CID) Music is by Ronald Jenkees

The post Episode 81. The Blessing of Vancozyn! The Association of Vancomycin and Zosyn in AKI appeared first on The Pharm So Hard Podcast.

This week on Pharm5: Polio in the US COVID vaccines linked to fewer CV events Vancomycin AUC vs. target troughs CMS Star Ratings 2022 Payment model is needed for Paxlovid prescribing Use APhA's pre-written, editable letter to advocate for pharmacist reimbursement for Paxlovid prescribing: https://bit.ly/3cKwm0O References: Meko H. First polio case in nearly a decade is detected in New York State. The New York Times. https://nyti.ms/3JbGLid. Published July 21, 2022. Accessed July 28, 2022. Polio vaccine effectiveness and duration of protection. Centers for Disease Control and Prevention. https://bit.ly/3JhiIyy. Published May 4, 2018. Accessed July 28, 2022. Kim Y-E, Huh K, Park Y-J, Peck KR, Jung J. Association between vaccination and acute myocardial infarction and ischemic stroke after COVID-19 infection. JAMA. July 2022. doi:10.1001/jama.2022.12992 Abdelmessih E, Patel N, Vekaria J, et al. Vancomycin area under the curve versus trough only guided dosing and the risk of acute kidney injury: Systematic Review and meta‐analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. July 2022. doi:10.1002/phar.2722 Chung D, Efta J, Brunsman A, et al. Evaluation of pharmacist time dedicated to vancomycin dosing in adult patients using a 24-hour AUC nomogram or Trough Monitoring Approach: A time motion study. American Journal of Health-System Pharmacy. 2022;79(14):1173-1179. doi:10.1093/ajhp/zxac094 Press release CMS releases 2022 Medicare Advantage and Part D star ratings to help Medicare beneficiaries compare plans. CMS. https://go.cms.gov/3oEzpKM. Accessed July 28, 2022. Emergency action is necessary to provide payment for pharmacist prescribing of Paxlovid. OneClickPolitics. https://bit.ly/3cKwm0O. Accessed July 28, 2022.

Show notes at pharmacyjoe.com/episode732. In this episode, I'll discuss an article that suggests the vancomycin - piperacillin-tazobactam AKI interaction just pseudotoxicity. The post 732: Is the vancomycin - piperacillin-tazobactam AKI interaction just pseudotoxicity? appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode732. In this episode, I ll discuss an article that suggests the vancomycin piperacillin-tazobactam AKI interaction just pseudotoxicity. The post 732: Is the vancomycin piperacillin-tazobactam AKI interaction just pseudotoxicity? appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode711. In this episode, I'll discuss the possibility of vancomycin treatment failure with old CVVHDF dosing regimens. The post 711: Beware of vancomycin treatment failure with old CVVHDF dosing regimens appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode711. In this episode, I ll discuss the possibility of vancomycin treatment failure with old CVVHDF dosing regimens. The post 711: Beware of vancomycin treatment failure with old CVVHDF dosing regimens appeared first on Pharmacy Joe.

On the first episode of the Infectious Disease Puscast, Daniel and Sara bring Marc Crislip's well known Puscast back to life, and present a review of the infectious disease literature for the previous two weeks, 4/13 – 4/27/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabies from an anteater (MMWR) Oral Tebipenem Pivoxil Hydrobromide in Complicated UTI (NEJM) Therapeutic monitoring of vancomycin for serious MRSA infections (IDSA) Time to retire Vancomycin for MRAS Endovascular Infections? (Op Forum Inf Dis) Impact of ID consultation on outcome of patients with enterococcal bacteremia (Op Forum Inf Dis) Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia (JAMA) Effect of Antimicrobial Prophylaxis Duration on Health Care-Associated Infections After Clean Orthopedic Surgery (JAMA) Randomized Clinical Trial Comparing Seven Versus Fourteen Days of Antibiotics for Uncomplicated Gram-Negative Bloodstream Infection (Op Forum Inf Dis) Vehicle Windshield Wiper Fluid as Potential Source of Sporadic Legionnaires' Disease in Commercial Truck Drivers (MMWR) Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (NEJM) High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine (JID) Association of Reduced Long-Lasting Insecticidal Net Efficacy and Pyrethroid Insecticide Resistance With Overexpression of CYP6P4, CYP6P3, and CYP6Z1 in Populations of Anopheles coluzzii From Southeast Côte d'Ivoire (J Inf Dis) Intro music is by Ronald Jenkees Send your questions for Puscast to puscast@microbe.tv

Recognize common presentations of anaphylaxis and stop under-treating this deadly allergic reaction with tips from Dr. Olajumoke Fadugba, Assistant Professor of Medicine, University of Pennsylvania! We review the basic pathophysiology and the standard criteria for diagnosing anaphylaxis, treatment basics, the primary importance of epinephrine, and the utility of adjunctive therapies. Also included are great tips on counseling patients about auto-injectable epinephrine, and a reminder not to panic…even when you inject your own thumb?! Original show notes here. Show Notes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Producer, infographic, and cover art: Emi Okamoto MD Hosts: Matthew Watto MD, FACP; Stuart Brigham MD, Emi Okamoto MD Editor: Matthew Watto MD, FACP Guest: Olajumoke Fadugba MD Special thanks to Sarah Phoebe Roberts MPH for booking! Show Segments Intro and disclaimer Guest one-liner, book recommendation, advice to fellows and trainees Case of anaphylaxis with mucocutaneous and GI symptoms Anaphylaxis (IgE mediated mast cell action) vs anaphylactoid (non-IgE mediated mast cell activation; e.g. contrast allergy, vancomycin) Vancomycin and non-IgE mediated reactions Common presentations of anaphylaxis and the three diagnostic criteria Biphasic reactions and predicting severity Counseling patients on the use of epinephrine Stuart's thumb question Adjuvant medications: antihistamines and corticosteroids Are there any contraindications to epinephrine use? Use of tryptase levels when the diagnosis of anaphylaxis is uncertain Outro Sponsor Medmastery - Visit www.medmastery.com/curbsiders for a 15% lifetime discount! 

Show notes at pharmacyjoe.com/episode669. In this episode, I’ll discuss a recent article about vancomycin monitoring. The post 669: Is this the most important article on vancomycin ever published? appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode652. In this episode, I’ll discuss which antibiotic should be given first in sepsis – the beta-lactam or the vancomycin? The post 652: Which should be given first – the beta-lactam or the vancomycin? appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode616. . In this episode, I'll discuss whether it is ever appropriate for a patient to be on oral and IV vancomycin. The post 616: Is it ever appropriate for a patient to be on oral and IV vancomycin? appeared first on Pharmacy Joe.

Show note at pharmacyjoe.com/episode611 . In this episode, I'll discuss what phenotype of patients are most affected by delays in antibiotic therapy. The post 611: How well does Bayesian Vancomycin Monitoring Work in the Critically Ill? appeared first on Pharmacy Joe.