Podcasts about s2352

This World Shared Practice Forum Podcast episode features a discussion on the article "Building Global Collaborative Research Networks in Pediatric Critical Care: A Roadmap," published in Lancet Child and Adolescent Health in February 2025. The conversation, led by Dr. Jeff Burns with guests Professor Luregn Schlapbach and Professor Padmanabhan Ramnarayan, explores the challenges and strategies for creating effective global research networks in pediatric critical care. The speakers highlight the importance of collaboration, the need for a robust evidence base, and the potential of large data models to drive the future of precision medicine and improve patient outcomes. LEARNING OBJECTIVES - Understand the current landscape and challenges of pediatric critical care research - Identify the key components and benefits of global collaborative research networks - Learn about the action plans and goals for advancing global pediatric critical care research AUTHORS Luregn Schlapbach, MD, PhD, Prof, FCICM Head, Department of Intensive Care and Neonatology University Children's Hospital in Zurich, Switzerland Padmanabhan "Ram" Ramnarayan, MBBS, MD, FRCPCH, FFICM Professor of Paediatric Critical Care Imperial College London Jeffrey Burns, MD, MPH Emeritus Chief Division of Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anesthesia Harvard Medical School DATE Initial publication date: May 26, 2025. ARTICLE REFERENCED Schlapbach LJ, Ramnarayan P, Gibbons KS, et al. Building global collaborative research networks in paediatric critical care: a roadmap. Lancet Child Adolesc Health. 2025;9(2):138-150. doi:10.1016/S2352-4642(24)00303-1 TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/at/7hptjhbmtkv8sqx7m86934/202505_WSP_Schlapbach_and_Ramnarayan_Transcript-3864x5000-258ba60.pdf Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Schlapbach LJ, Ramnarayan P, Burns JP. Building Global Pediatric Research Networks. 05/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/building-global-pediatric-research-networks-by-l-schlapbach-p-ramnarayan-openpediatrics.

Send us a textMeet Dr. Mark Mofid, inventor of Sylke, the first wound dressing made of pure hypoallergenic silk fibroin.  Could this really be the end of "contact dermatitis" in wound closure?In this episode you will learn:Why super glue triggers contact dermatitisThe benefits of silk fibroin for woundsWhy my Mom hates staplesWhat Ortho can learn from Plastics regarding marketingWhat happened to Michael Jackson's noseWhy the subject of Buttock augmentation is EVEN on the show!...and so much more!This is a special episode, as it's so informative on so many different topics.  Make sure to listen to the end, as I share my personal experience with this product in MY bag!Contact them today at: devicenation@sylke.comLearn more here: https://www.sylke.com/RUSH paper: https://pubmed.ncbi.nlm.nih.gov/40349859/Arthroplasty Today: https://www.arthroplastytoday.org/article/S2352-3441(25)00055-X/fulltextModern Aesthetics: https://modernaesthetics.com/news/meet-sylke-the-first-wound-dressing-made-of-pure-hypoallergenic-silk-fibroinAesthetic Surgery Journal: https://academic.oup.com/asjopenforum/article/doi/10.1093/asjof/ojad071/7238111?login=falseSupport the show

Send us a textHigher versus lower nasal continuous positive airway pressure for extubation of extremely preterm infants in Australia (ÉCLAT): a multicentre, randomised, superiority trial.Kidman AM, Manley BJ, Boland RA, Malhotra A, Donath SM, Beker F, Davis PG, Bhatia R.Lancet Child Adolesc Health. 2023 Dec;7(12):844-851. doi: 10.1016/S2352-4642(23)00235-3. Epub 2023 Oct 27.PMID: 38240784 Clinical Trial.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this World Shared Practice Forum podcast, Dr. Jeffrey Burns converses with experts Drs. Akash Deep, James Squires, and Barbara Wildhaber about pediatric acute liver failure and the intricacies of deciding when a child is unsuitable for liver transplantation. Discussing insights from their 2024 Lancet Child Health and Adolescent Health paper, they emphasize the importance of a multidisciplinary approach in evaluating clinical, biochemical, psychosocial, and ethical factors. The conversation highlights challenges with exclusion criteria, risks associated with severe multi-organ failure, and the necessity of balancing technical feasibility with overall patient prognosis, while also addressing the ethical implications of organ allocation. LEARNING OBJECTIVES - Identify key clinical and biochemical factors in evaluating pediatric liver transplant suitability - Discuss the ethical and logistical considerations impacting transplant decisions in critically ill children with liver failure - Summarize multidisciplinary approaches for determining when a child may be unsuitable for a liver transplant AUTHORS Akash Deep, MD, FRCPCH Director - Paediatric Intensive Care Unit and Staff Governor King's College Hospital, London Professor in Paediatric Critical Care King's College London James Squires, MD, MS Associate Professor, Pediatrician UPMC Children's Hospital of Pittsburgh Barbara Wildhaber, MD Professor University Hospitals of Geneva Chief Physician Child and Adolescent Surgery Swiss Pediatric Liver Center Jeffery Burns, MD, MPH Emeritus Chief Division of Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anesthesia Harvard Medical School DATE Initial publication date: February 25, 2025. ARTICLE REFERENCED Deep A, Alexander EC, Brierley J, Damian M, Gupta A, McLin V, Sarma MS, Squires JE, Wildhaber BE. Paediatric acute liver failure: a multidisciplinary perspective on when a critically ill child is unsuitable for liver transplantation. Lancet Child Adolesc Health. 2024 Dec;8(12):921-932. doi: 10.1016/S2352-4642(24)00255-4. TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/at/kn5r4s2wrnh3pm24gb9hkpvk/022025_WSP_Deep_Transplant_Challenges_in_Pediatric_Liver_Failure_Transcript.pdf Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Deep A, Squires J, Wildhaber BE, Burns JP. Transplant Challenges in Pediatric Liver Failure. 02/2025. OPENPediatrics. Online Podcast: https://soundcloud.com/openpediatrics/transplant-challenges-in-pediatric-liver-failure-by-a-deep-et-al-openpediatrics.

We are back with more exciting IDWeek 2024 content. In this episode, Breakpoints hostesses Drs. Erin McCreary, Julie Ann Justo, Jeannette Bouchard, and Megan Klatt highlight more of our favorite sessions and posters at IDWeek, this episode is a must listen if you are an IDWeek nerd like us! References: Perret et al. Application of OpenAI GPT-4 for the retrospective detection of catheter-associated urinary tract infections in a fictitious and curated patient data set. 10.1017/ice.2023.189 Wiemken et al. Assisting the infection preventionist: Use of artificial intelligence for health care–associated infection surveillance. 10.1016/j.ajic.2024.02.007 Leekha et al. Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study. 10.1136/bmjqs-2023-016831 Diekema et al. Are Contact Precautions "Essential" for the Prevention of Healthcare-associated Methicillin-Resistant Staphylococcus aureus? 10.1093/cid/ciad571 Martin et al. Contact precautions for MRSA and VRE: where are we now? A survey of the Society for Healthcare Epidemiology of America Research Network. 10.1017/ash.2024.350 Browne et al. Investigating the effect of enhanced cleaning and disinfection of shared medical equipment on health-care-associated infections in Australia (CLEEN): a stepped-wedge, cluster randomised, controlled trial. 10.1016/S1473-3099(24)00399-2 Protect trial: Decolonization in Nursing Homes to Prevent Infection and Hospitalization. 10.1056/NEJMoa2215254 Aldardeer et al. Early Versus Late Antipseudomonal β-Lactam Antibiotic Dose Adjustment in Critically Ill Sepsis Patients With Acute Kidney Injury: A Prospective Observational Cohort Study. 10.1093/ofid/ofae059 Schmiemann et al. Effects of a multimodal intervention in primary care to reduce second line antibiotic prescriptions for urinary tract infections in women: parallel, cluster randomised, controlled trial. 10.1136/bmj-2023-076305 Vernacchio et al. Improving Short Course Treatment of Pediatric Infections: A Randomized Quality Improvement Trial. 10.1542/peds.2023-063691 Advani et al. Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria. 10.1001/jamanetworkopen.2024.2283 Saif et al. Clinical decision support for gastrointestinal panel testing. 10.1017/ash.2024.15 Bekker et al. Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women. 10.1056/NEJMoa2407001 Montini et al. Short Oral Antibiotic Therapy for Pediatric Febrile Urinary Tract Infections: A Randomized Trial. 10.1542/peds.2023-062598 Nielsen et al. Oral versus intravenous empirical antibiotics in children and adolescents with uncomplicated bone and joint infections: a nationwide, randomised, controlled, non-inferiority trial in Denmark. 10.1016/S2352-4642(24)00133-0 Kaasch et al. Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial. 10.1016/S1473-3099(23)00756-9 AMIKINHAL: Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia. 10.1056/NEJMoa2310307 PROPHY-VAP: Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial. 10.1016/S2213-2600(23)00471-X AVENIR: Azithromycin to Reduce Mortality — An Adaptive Cluster-Randomized Trial. 10.1056/NEJMoa2312093 Thomas et al. Comparison of Two High-Dose Versus Two Standard-Dose Influenza Vaccines in Adult Allogeneic Hematopoietic Cell Transplant Recipients. 10.1093/cid/ciad458 Schuster et al. The Durability of Antibody Responses of Two Doses of High-Dose Relative to Two Doses of Standard-Dose Inactivated Influenza Vaccine in Pediatric Hematopoietic Cell Transplant Recipients: A Multi-Center Randomized Controlled Trial. 10.1093/cid/ciad534 Mahadeo et al. Tabelecleucel for allogeneic haematopoietic stem-cell or solid organ transplant recipients with Epstein-Barr virus-positive post-transplant lymphoproliferative disease after failure of rituximab or rituximab and chemotherapy (ALLELE): a phase 3, multicentre, open-label trial. 10.1016/S1470-2045(23)00649-6 Khoury et al. Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant. 10.1016/j.ajt.2024.04.009 Spec et al. MSG-15: Super-Bioavailability Itraconazole Versus Conventional Itraconazole in the Treatment of Endemic Mycoses—A Multicenter, Open-Label, Randomized Comparative Trial. 10.1093/ofid/ofae010

Reviewing 3 recent AML publications Double-Dauno (90 mg/m2 vs. 60 mg/m2): https://doi.org/10.1200/JCO.24.00235 AML60+ Risk Stratification: https://doi.org/10.1200/JCO.23.02631 Decitabine-Ven as bridge to Allo HSCT: https://doi.org/10.1016/S2352-3026(24)00241-2

Host: Jennifer Caudle, DO Guest: Samuel R. Wilson, MD Sickle cell disease is among the most common inherited conditions globally, affecting more than seven million individuals worldwide.1-3 Given its prevalence, it is important to understand all of the complexities surrounding this disease. Joining Dr. Jennifer Caudle to discuss the pathophysiology, clinical presentation, burden, and unmet needs of sickle cell disease is Dr. Samuel R. Wilson, Assistant Professor of Medicine in the Division of Hematology at the University of North Carolina School of Medicine. References: Sedrak A, Kondamudi NP. Sickle cell disease. StatPearls Publishing; 2023. Updated August 12, 2023. Accessed April 16, 2024. https://www.ncbi.nlm.nih.gov/books/NBK482384/. Thomson AM, McHugh TA, Oron AP, et al. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Haematol. 2023;10(8):e585-e599. doi:10.1016/S2352-3026(23)00118-7. CDC. Data & statistics on sickle cell disease. Centers for Disease Control and Prevention. Published May 2, 2022. Accessed April 16, 2024. https://www.cdc.gov/ncbddd/sicklecell/data.html/. Agios Pharmaceuticals, Inc. © 2024 All right reserved.SCD-US-0095 / June 2024

Host: Jennifer Caudle, DO Guest: Samuel R. Wilson, MD Sickle cell disease is among the most common inherited conditions globally, affecting more than seven million individuals worldwide.1-3 Given its prevalence, it is important to understand all of the complexities surrounding this disease. Joining Dr. Jennifer Caudle to discuss the pathophysiology, clinical presentation, burden, and unmet needs of sickle cell disease is Dr. Samuel R. Wilson, Assistant Professor of Medicine in the Division of Hematology at the University of North Carolina School of Medicine. References: Sedrak A, Kondamudi NP. Sickle cell disease. StatPearls Publishing; 2023. Updated August 12, 2023. Accessed April 16, 2024. https://www.ncbi.nlm.nih.gov/books/NBK482384/. Thomson AM, McHugh TA, Oron AP, et al. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Haematol. 2023;10(8):e585-e599. doi:10.1016/S2352-3026(23)00118-7. CDC. Data & statistics on sickle cell disease. Centers for Disease Control and Prevention. Published May 2, 2022. Accessed April 16, 2024. https://www.cdc.gov/ncbddd/sicklecell/data.html/. Agios Pharmaceuticals, Inc. © 2024 All right reserved.SCD-US-0095 / June 2024

In this episode, we delve into a pivotal multi-center study validating the Pediatric Emergency Care Applied Research Network (PECARN) prediction rules for using CT imaging in children with blunt abdominal and minor head trauma. We discuss with the authors the study's impact, how these validated rules can optimize pediatric trauma care, minimize radiation risks, and what this means for emergency practices worldwide. This conversation not only sheds light on the study's intricate processes and outcomes, but also emphasizes the vital role of evidence-based guidelines in enhancing patient safety and care quality. Host: Dr. Julia Magaña, Associate Professor of Pediatric Emergency Medicine at UC Davis Guests: Dr. Nate Kuppermann, Pediatric Emergency Physician, Professor and Chair of the UC Davis Department of Emergency Medicine, Founding Chair of the PECARN Steering Committee Dr. James Holmes, Professor of Emergency Medicine at UC Davis Resources: Holmes JF, Yen K, Ugalde IT, Ishimine P, Chaudhari PP, Atigapramoj N, Badawy M, McCarten-Gibbs KA, Nielsen D, Sage AC, Tatro G, Upperman JS, Adelson PD, Tancredi DJ, Kuppermann N. PECARN prediction rules for CT imaging of children presenting to the emergency department with blunt abdominal or minor head trauma: a multicentre prospective validation study. Lancet Child Adolesc Health. 2024 May;8(5):339-347. doi: 10.1016/S2352-4642(24)00029-4. PMID: 38609287. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(24)00029-4/abstract ***** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.

Neste Episodio falaremos da Fisetina, um Stack Senoliticos, que mata células Senis. O que é Fisetina? Onde encontro na Natureza? Doses? Quais promessas e Riscos? Quais Evidencias? Aprofunde seus Conhecimentos na nossa Pos Graduação de Medicina integrativa: https://drdupr.at/pos Referências: •https://www.frontiersin.org/articles/10.3389/fphar.2022.1015835/full• doi: 10.3390/biom9050174 doi: 10.1007/s10522-023-10064-9.  doi: 10.1152/physrev.00020.2018. doi: 10.1172/JCI95148.  https://www.thelancet.com/article/S2352-3964(1830373-6/fulltext#articleInformation•  doi: 10.1016/j.ebiom.2018.09.015. https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions https://doi.org/10.1038/s41598-021-87257-0

Aggressive hematologic malignancy publications can be challenging to interpret and translate to clinical practice. We look at two recent studies to illustrate this point. Elderly AML: 10-day decitabine vs. 7 + 3 (https://doi.org/10.1016/S2352-3026(23)00273-9) Burkitt Lymphoma: R-CODXO-M/R-IVAC vs. DA-R-EPOCH (https://doi.org/10.1016/S2352-3026(23)00279-X)

Find Monica:  Website: https://monicasdeepdives.com Twitter: https://twitter.com/monicaperezshow Rokfin: https://rokfin.com/deepdives Rumble: https://rumble.com/user/monicaperezshow YouTube: https://www.youtube.com/c/MonicaPerez  Shownotes: 1) EMA Quality Report - Rapporteurs-Rolling-Review-Report-Quality-COVID-19-mRNA-Vaccine- BioNTec.doc (live.com) 2) SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination: https://onlinelibrary.wiley.com/doi/10.1111/apm.13294 3) Biodistribution of mRNA COVID-19 vaccines in human breast milk https://www.thelancet.com/action/showPdf?pii=S2352-3964%2823%2900366-3 4) FDA - Emergency Use Authorization (EUA) for an Unapproved Product Review Memorandum https://www.fda.gov/media/144416/download 5) EMA Comirnaty Assessment Report - https://www.ema.europa.eu/en/documents/assessment- report/comirnaty-epar-public-assessment-report_en.pdf 6) Three decades of messenger RNA vaccine development - ScienceDirect 7) Frontiers | Are There Hidden Genes in DNA/RNA Vaccines? (frontiersin.org) 8) Effect of mRNA Vaccine Manufacturing Processes on Efficacy and Safety Still an Open Question | The BMJ 9) Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line (nih.gov) 10) dsDNA variance in Pfizer Docs - by Anandamide (substack.com) 11) COVID-19 primary series and booster vaccination and immune imprinting https://www.medrxiv.org/content/10.1101/2022.10.31.22281756v1.full.pdf 12) Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025 13) A SYSTEMATIC REVIEW OF AUTOPSY FINDINGS IN DEATHS AFTER COVID-19 VACCINATION: https://zenodo.org/record/8120771 14) Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine (Cleveland Clinic Study): https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false 15) Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents: https://pubmed.ncbi.nlm.nih.gov/36006288/ 16) Deep sequencing of the Moderna and Pfizer bivalent vaccines identifies contamination of expression vectors designed for plasmid amplification in bacteria | Kevin McKernan: https://rumble.com/v2c785k-march-8-2023.html?mref=umbzp&mc=dprv6 17) BNT162b2 Vaccine-Associated Myo/Pericarditis in Adolescents: A Stratified Risk-Benefit Analysis: https://onlinelibrary.wiley.com/doi/10.1111/eci.13759 18) SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents: https://jamanetwork.com/journals/jamacardiology/fullarticle/2791253 19) Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults: https://www.sciencedirect.com/science/article/pii/S0264410X22010283 20) N1 methylpseudouridine is incorporated with higher fdelity than pseudouridine in synthetic RNAs (demonstrates high error rates) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335462/pdf/41598_2022_Article_17249.pdf 22) LNP packaging of dsDNA: https://anandamide.substack.com/p/lnp-packaging-of-dsdna 23) IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/ 24) COVID-19 vaccine-associated mortality in the Southern Hemisphere: https://correlation- canada.org/covid-19-vaccine-associated-mortality-in-the-southern-hemisphere/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Find Monica:  Website: https://monicasdeepdives.com Twitter: https://twitter.com/monicaperezshow Rokfin: https://rokfin.com/deepdives Rumble: https://rumble.com/user/monicaperezshow YouTube: https://www.youtube.com/c/MonicaPerez  Shownotes: 1) EMA Quality Report - Rapporteurs-Rolling-Review-Report-Quality-COVID-19-mRNA-Vaccine- BioNTec.doc (live.com) 2) SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination: https://onlinelibrary.wiley.com/doi/10.1111/apm.13294 3) Biodistribution of mRNA COVID-19 vaccines in human breast milk https://www.thelancet.com/action/showPdf?pii=S2352-3964%2823%2900366-3 4) FDA - Emergency Use Authorization (EUA) for an Unapproved Product Review Memorandum https://www.fda.gov/media/144416/download 5) EMA Comirnaty Assessment Report - https://www.ema.europa.eu/en/documents/assessment- report/comirnaty-epar-public-assessment-report_en.pdf 6) Three decades of messenger RNA vaccine development - ScienceDirect 7) Frontiers | Are There Hidden Genes in DNA/RNA Vaccines? (frontiersin.org) 8) Effect of mRNA Vaccine Manufacturing Processes on Efficacy and Safety Still an Open Question | The BMJ 9) Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line (nih.gov) 10) dsDNA variance in Pfizer Docs - by Anandamide (substack.com) 11) COVID-19 primary series and booster vaccination and immune imprinting https://www.medrxiv.org/content/10.1101/2022.10.31.22281756v1.full.pdf 12) Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025 13) A SYSTEMATIC REVIEW OF AUTOPSY FINDINGS IN DEATHS AFTER COVID-19 VACCINATION: https://zenodo.org/record/8120771 14) Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine (Cleveland Clinic Study): https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false 15) Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents: https://pubmed.ncbi.nlm.nih.gov/36006288/ 16) Deep sequencing of the Moderna and Pfizer bivalent vaccines identifies contamination of expression vectors designed for plasmid amplification in bacteria | Kevin McKernan: https://rumble.com/v2c785k-march-8-2023.html?mref=umbzp&mc=dprv6 17) BNT162b2 Vaccine-Associated Myo/Pericarditis in Adolescents: A Stratified Risk-Benefit Analysis: https://onlinelibrary.wiley.com/doi/10.1111/eci.13759 18) SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents: https://jamanetwork.com/journals/jamacardiology/fullarticle/2791253 19) Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults: https://www.sciencedirect.com/science/article/pii/S0264410X22010283 20) N1 methylpseudouridine is incorporated with higher fdelity than pseudouridine in synthetic RNAs (demonstrates high error rates) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335462/pdf/41598_2022_Article_17249.pdf 22) LNP packaging of dsDNA: https://anandamide.substack.com/p/lnp-packaging-of-dsdna 23) IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/ 24) COVID-19 vaccine-associated mortality in the Southern Hemisphere: https://correlation- canada.org/covid-19-vaccine-associated-mortality-in-the-southern-hemisphere/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Este podcast está presentado por los médicos neonatólogos Dani de Luis Rosell, Elena Itriago, y Carolina Michel; nuestras futuras doctoras Valentina Giraldo y Laura Molina y su anfitriona Maria Flores Cordova, médico residente de pediatría. Creado originalmente por el Dr. Ben Courchia y la Dra. Daphna Yasova Barbeau. No dudes en enviarnos preguntas, comentarios o sugerencias a nuestro correo electrónico: nicupodcast@gmail.com Los artículos que se tratan en el episodio de hoy están listados aquí: Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H.Epilepsia. 2023 Oct;64(10):2550-2570. doi: 10.1111/epi.17745. Epub 2023 Sep 1.Apgar Score and Neurodevelopmental Outcomes at Age 5 Years in Infants Born Extremely Preterm.Ehrhardt H, Aubert AM, Ådén U, Draper ES, Gudmundsdottir A, Varendi H, Weber T, Zemlin M, Maier RF, Zeitlin J; EPICE-SHIPS Research Group.JAMA Netw Open. 2023 Sep 5;6(9):e2332413. doi: 10.1001/jamanetworkopen.2023.32413.Prenatal Brain Maturation is Delayed in Neonates with Congenital Diaphragmatic Hernia.Johng S, Licht DJ, Hedrick HL, Rintoul N, Linn RL, Gebb JS, Xiao R, Massey SL.J Pediatr. 2023 Sep 16;264:113738. doi: 10.1016/j.jpeds.2023.113738. Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study.Ohuma EO, Jabin N, Young MF, Epie T, Martorell R, Peña-Rosas JP, Garcia-Casal MN; INTERBIO-21st Consortium; Papageorghiou AT, Kennedy SH, Villar J.Lancet Haematol. 2023 Sep;10(9):e756-e766. doi: 10.1016/S2352-3026(23)00170-9.Prenatal Intravenous Magnesium at 30-34 Weeks' Gestation and Neurodevelopmental Outcomes in Offspring: The MAGENTA Randomized Clinical Trial.Crowther CA, Ashwood P, Middleton PF, McPhee A, Tran T, Harding JE; MAGENTA Study Group.JAMA. 2023 Aug 15;330(7):603-614. doi: 10.1001/jama.2023.12357. Bienvenidos a La Incubadora: una conversación sobre neonatología y medicina basada en evidencia. Nuestros episodios ofrecen la dosis ideal (en mg/kg) de los más recientes avances para el neonato y para las increíbles personas que forman parte de la medicina neonatal. Soy tu host, Maria Flores Cordova, MD. Presentado por los Neonatólogos Elena Itriago MD, Dani de Luis Rosell MD, Carolina Michel MD, las futuras doctoras Marla Fortoul, Valentina Giraldo, Laura Molina. Creado originalmente por Ben Courchia MD y Daphna Yasova Barbeau MD http://www.the-incubator.org

In this World Shared Practice Forum podcast, Drs. Suchitra Ranjit and Luregn Schlapbach, discuss a framework to provide individualized hemodynamic support for pediatric patients with septic shock, especially those in lower and middle-income countries. The authors discuss considerations described in their expert group's recent article, including how to administer and assess the response of various therapies such as fluids, inotropes, and pressors. LEARNING OBJECTIVES By the end of this podcast, learners will be able to: - Describe the challenges to the early recognition of septic shock in children through a global lens - Introduce the concepts of flow, pressure, and filling in the context of septic shock and their clinical application - Discuss the individualized approach to fluid use in the treatment of septic shock in pediatric patients - Review the literature surrounding the use of fluids in pediatrics and adults AUTHORS Suchitra Ranjit, MD Chief, Pediatric Intensive Care Unit Apollo Children's Hospital, Chennai, India Luregn Schlapbach, Prof, MD, PhD, FCICM Head, Department of Intensive Care and Neonatology University Children`s Hospital Zurich, Switzerland DATES: Initial publication: August 22, 2023 CITATION: Ranjit S, Schlapbach LJ, O'Hara JE, Wolbrink TA. Individualized Hemodynamic Support for Pediatric Patients with Septic Shock. 08/2023. OPENPediatrics. Online Podcast. YT: https://youtu.be/AK6Uz_hZ_SY SC: https://soundcloud.com/openpediatrics/individualized-hemodynamic-support-for-pediatric-patients-with-septic-shock. ARTICLED REFERENCED: - Ranjit S, Kissoon N, Argent A, et al. Haemodynamic support for paediatric septic shock: a global perspective. Lancet Child Adolesc Health. 2023;7(8):588-598. doi:10.1016/S2352-4642(23)00103-7 - Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223-230. doi:10.1016/S2213-2600(18)30063-8 (1:15) - Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011;364(26):2483-2495. doi:10.1056/NEJMoa1101549 (4:58) - Gu W, Deng X, Lee M, et al. Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids. Nat Med. 2021;27(1):115-124. doi:10.1038/s41591-020-1105-z (14:02) - Meyhoff TS, Hjortrup PB, Wetterslev J, et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med. 2022;386(26):2459-2470. doi:10.1056/NEJMoa2202707 (24:50) - National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023;388(6):499-510. doi:10.1056/NEJMoa2212663 (24:52) Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Find the transcript and full list of references here (partial list below): ⁠My book, I Have Hashimoto's, Now What? ⁠ is now available! In this episode, we explore the vital role of iron in managing Hashimoto's! We're going to unpack the importance of iron for overall health, its specific function in thyroid hormone production, and the potential impact of iron deficiency on those with Hashimoto's. We're also going to delve into the strategies for dealing with iron deficiency, including dietary adjustments and targeted supplementation. If you're dealing with Hashimoto's, or are interested in understanding more about this autoimmune disorder, this episode provides valuable insights drawn from research and from personal experience. Listen in to shed light on how addressing iron deficiency can be a significant part of managing Hashimoto's and improving your thyroid health! Resources Favorite Brands of Iron Supplements (FYI not sponsored but affiliate links to help support the pod) Opti-Ferrin C. This product includes vitamin C for better absorption. It's the highest quality one in this list, but I need to take it with food or else it hurts my stomach. Liquid Iron. Taking iron in liquid form can help with absorption and be easier on the stomach. However, taking it in liquid form is not for everyone because it's a bit messier. It's up to you! Blood Builder. This brand can be found at Whole Foods and it's the first brand I found that basically did not hurt my stomach at all. I didn't even need to take it with food. And I think it was pretty effective. Book⁠⁠: I Have Hashimoto's, Now What? ⁠⁠Workbook⁠⁠: Hashimoto's Self-Care Checklist Journal Let's Stay Connected! Instagram Newsletter Podcast References Find a full list of references in the transcript! Zimmermann, M. B., & Köhrle, J. (2002). The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid, 12(10), 867-878. DOI: 10.1089/105072502761016494 Erdogan, M., Kösenli, A., Ganidagli, S., & Kulaksizoglu, M. (2012). Characteristics of anemia in subclinical and overt hypothyroid patients. Endocrine Journal, 59(3), 213-220. DOI: 10.1507/endocrj.EJ11-0255 Hershko, C., & Skikne, B. (2009). Pathogenesis and management of iron deficiency anemia: emerging role of celiac disease, helicobacter pylori, and autoimmune gastritis. Seminars in Hematology, 46(4), 339-350. DOI: 10.1053/j.seminhematol.2009.06.001 Stoffel, N. U., Cercamondi, C. I., Brittenham, G., Zeder, C., Geurts-Moespot, A. J., Swinkels, D. W., ... & Zimmermann, M. B. (2017). Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. The Lancet Haematology, 4(11), e524-e533. DOI: 10.1016/S2352-3026(17)30182-5 Lopez, A., Cacoub, P., Macdougall, I. C., & Peyrin-Biroulet, L. (2016). Iron deficiency anaemia. The Lancet, 387(10021), 907-916. DOI: 10.1016/S0140-6736(15)60865-0

No one wants to be surveilled. It's the reason we put tape over our webcams and diligently monitor privacy settings on our phones. Being watched makes you feel like you're already guilty, and someone is just waiting for you to slip up. For people living with HIV, being monitored—and being treated like criminals—isn't some speculative, dystopian fear. It's a constant reality. And as we'll explore in this episode, it's a reality that could see innocent people serving lifetime sentences simply for engaging in consensual sex. Our guests are: Alexander McClelland, an interdisciplinary socio-legal researcher working to reform HIV criminalization policies in Canada. He recounts his experiences with having his sex life policed and scrutinized since being diagnosed with HIV at age 18. McClelland also shares harrowing details about the lengths some people living with HIV must go to in order to prove they have disclosed their status with partners. Robert Suttle, an HIV racial justice leader who serves on the HIV Justice Network's Global Advisory Panel. He shares his story of losing his job, getting arrested, and being forced to register as a sex offender when a former partner accused him of failing to disclose his HIV status. This podcast was created and fully funded by Gilead Sciences, Inc. GILEAD, the GILEAD logo, and the & design are trademarks of Gilead Sciences, Inc. © 2023 Gilead Sciences, Inc. All rights reserved. IHQ-UNB-4185 Date of Preparation July 2023. References: Sullivan PS, Woodyatt C, Koski C, et al. A data visualization and dissemination resource to support HIV prevention and care at the local level: analysis and uses of the AIDSVu Public Data Resource. Journal of medical Internet research. 2020;22(10):e23173. Calabrese SK, Mayer KH. Lancet: Providers Should Discuss U=U with All Patients Living with HIV. Lancet HIV. 2019;6(4):e211-e213. doi: 10.1016/S2352-3018(19)30030-X US Department of Health and Human Services. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. March 2023. Accessed July 7, 2023. Available at: https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/adult-adolescent-arv/guidelines-adult-adolescent-arv.pdf Kavanagh MM, Agbla SC, Joy M, et al. Law, criminalisation and HIV in the world: have countries that criminalise achieved more or less successful pandemic response? BMJ Global Health. 2021;6:e006315. doi:10.1136/bmjgh-2021-006315 McClelland A. The Criminalization of HIV Non-Disclosure in Canada: Experiences of People Living with HIV. 2019 Ratevosian J. Legal and policy barriers for an effective HIV/AIDS response. Lancet. 2023;401(10386):1405-1407. doi: 10.1016/S0140-6736(23)00729-8 Symington A, Bernard EJ, et al. Advancing HIV Justice 4: Understanding Commonalities, Seizing Opportunities. HIV Justice Network; Amsterdam. July 2022. Fact sheet 2022. Global HIV statistics. Accessed July 7, 2023. https://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf

Be honest. How often do you start your morning pounding the snooze button or scrolling your phone under the covers? I'm going to be real with you: You're sabotaging your entire day when you start your morning that way. This week, I'm breaking down the science behind why starting your morning off on the right foot doesn't just give you a natural energy boost. It also dictates your mood, performance, and energy levels from morning to night. And not only that—you sleep better when you start your day off right, too!  Here's the good news: There are three super easy steps you can take to kick off a great morning—including one I was very skeptical about, but is now something I'll never give up. And the best part is, these daily habits are free and accessible to all. Plus, towards the end of the show, I'm revealing my personal morning routine (hint: it involves some shivering).  Tune in today so you can start doing these three things tomorrow!  Full show notes: jjvirgin.com/peakenergy Andrew Huberman recommends 2-10 minutes of morning sunlight exposure to improve mood, energy, and focus. Learn more at: Andrew Huberman's Light & Sun Exposure Guide https://medium.com/@podclips/andrew-hubermans-light-sun-exposure-guide-dd62a43314df Read the study on how sun exposure can improve sleep and mood: https://www.sleephealthjournal.org/article/S2352-7218(17)30041-4/fulltext Use light-therapy lamps with 10,000 LUX output to mimic natural sunlight. To try, visit: https://amzn.to/3BYHgt3 I just learned about using a Philips sunrise alarm clock to wake peacefully to natural light and the sounds of chirping birds. Get yours at: https://amzn.to/43vDIKv Make sure you have a full-spectrum light bulb with sun-mimicking technology to boost energy and mood. To try, visit: https://amzn.to/3ON692N  At night, switch your bulbs over to red to remind your brain it's time to wind down. To try, visit: https://amzn.to/3MZAwSf Use blue-blocker glasses to minimize blue-light exposure before bed. Use my code JJ10 to get 10% off stylish TrueDark Premium blue-light glasses: https://truedark.com/?ref=ntrhmgv2   Dr. Joe Dispenza's meditation retreats helped me improve my life. Try one of his guided morning meditations here: https://drjoedispenza.com/?rfsn=6914154.37386a&utm_source=refersion&utm_medium=affiliate&utm_campaign=6914154.37386a  Or if you like relaxing music, I love the meditations he does with Barry Goldstein's music. Find one here: https://drjoedispenza.com/products/ambiology-1-the-heart-by-barry-goldstein-music-compilation-download?rfsn=6914154.37386a&utm_source=refersion&utm_medium=affiliate&utm_campaign=6914154.37386a Try different methods of meditation to see what works for you. A favorite of mine is The Tapping Solution by Nick Ortner. Try it here: https://thetappingsolutionapp.com/jj  Read the study on how meditation can change the structure of your brain associated with memory, learning, emotional regulation, and perspective taking: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004979/: Finding your personal mantra with Ziva Meditation might be another way you release stress and learn to love meditation. Try it now: https://cd371.isrefer.com/go/3secrets/JJ110/ Read the study on why working out in the morning is better for fat loss: https://www.pnas.org/doi/10.1073/pnas.2218510120  Starting my day with a cold plunge refreshes my mind and body. Use my code JJVIP1000 for $1,000 off of yours: https://www.koorucoldplunges.com

The seminal publication of the AAP's Guideline on the Evaluation and Treatment of Children and Adolescents with Obesity serves as the source of our fifth episode in the series on Health Equity in Children.  The best practices for managing obesity go beyond discussions of beauty and body image to include systemic racism, obesity as a chronic disease, and the reckoning that children and adolescents with obesity are people first. Want to make a bigger difference in health equity? Complete an anonymous survey here after you listen to the episode or visit www.thepedsnp.com and click the “Complete a Survey” button at the top of the page. The responses will provide greater insight into how podcasts impact education and behavior through microlearning of health equity concepts. After you complete a survey, you'll receive a separate link to enter your email to a raffle for a $15 Amazon gift card.  Winners will be chosen at random and notified by email one week after the original publication date. This raffle was made possible by grant funding from the sources below.  Disclaimer: This series was supported by the North Carolina Chapter of the National Association of Pediatric Nurse Practitioners (NAPNAP) Dr. Rasheeda Monroe Health Equity grant whose mission is to support research and quality improvement aimed at improving health equity among infants, children, and adolescents. The content of this episode reflects my views and does not necessarily represent, nor is an endorsement of, NC NAPNAP or the Dr. Rasheeda Monroe Health Equity grant.  For more information, please community.napnap.org/northcarolinachapter. References Bell, C. N., Kerr, J., & Young, J. L. (2019). Associations between Obesity, Obesogenic Environments, and Structural Racism Vary by County-Level Racial Composition. International journal of environmental research and public health, 16(5), 861. https://doi.org/10.3390/ijerph16050861 Centers for Disease Control and Prevention. (2022). Inclusive communication principles. Gateway to Health Communication. https://www.cdc.gov/healthcommunication/Key_Principles.html Gmeiner, M. S., & Warschburger, P. (2020). Intrapersonal predictors of weight bias internalization among elementary school children: a prospective analysis. BMC pediatrics, 20(1), 408. https://doi.org/10.1186/s12887-020-02264-w Hadjiyannakis, S., Ibrahim, Q., Li, J., Ball, G. D. C., Buchholz, A., Hamilton, J. K., Zenlea, I., Ho, J., Legault, L., Laberge, A. M., Thabane, L., Tremblay, M., & Morrison, K. M. (2019). Obesity class versus the Edmonton Obesity Staging System for Pediatrics to define health risk in childhood obesity: results from the CANPWR cross-sectional study. The Lancet. Child & adolescent health, 3(6), 398–407. https://doi.org/10.1016/S2352-4642(19)30056-2 Hampl, S. E., Hassink, S. G., Skinner, A. C., Armstrong, S. C., Barlow, S. E., Bolling, C. F., Avila Edwards, K. C., Eneli, I., Hamre, R., Joseph, M. M., Lunsford, D., Mendonca, E., Michalsky, M. P., Mirza, N., Ochoa, E. R., Sharifi, M., Staiano, A. E., Weedn, A. E., Flinn, S. K., Lindros, J., … Okechukwu, K. (2023). Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity. Pediatrics, 151(2), e2022060640. https://doi.org/10.1542/peds.2022-060640 Haqq, A. M., Kebbe, M., Tan, Q., Manco, M., & Salas, X. R. (2021). Complexity and Stigma of Pediatric Obesity. Childhood obesity (Print), 17(4), 229–240. https://doi.org/10.1089/chi.2021.0003 Puhl, R. M., & Himmelstein, M. S. (2018). Adolescent preferences for weight terminology used by health care providers. Pediatric obesity, 13(9), 533–540. https://doi.org/10.1111/ijpo.12275 Puhl, R. M., Peterson, J. L., & Luedicke, J. (2011). Parental perceptions of weight terminology that providers use with youth. Pediatrics, 128(4), e786–e793. https://doi.org/10.1542/peds.2010-3841 Yan J, Liu L, Zhu Y, Huang G, Wang PP. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health. 2014 Dec 13;14:1267. doi: 10.1186/1471-2458-14-1267. PMID: 25495402; PMCID: PMC4301835.

In their last episode, Ashley and Megan talk about George Hodel's obsession with the surrealist art movement, which seemingly dictated his values and how he lived his entire adult life. Mark Nelson, author of The Exquisite Corpse, described surrealism as “an interplay of irrationality, eroticism, and violence…recurring in a broad array of writings and art.” Those sound like excellent themes to live by!Trigger Warning: Generally explicit material.Special thanks to Rasha Pecoraro and Yvette Gentile for allowing us to tell their family's story. We respect the hell out of these incredible women.Find the podcast that this season is based on, Root of Evil: The True Story of the Hodel Family and the Black Dahlia, here:https://podcasts.apple.com/us/podcast/root-of-evil-the-true-story-of-the/id1450277129Find Rasha and Yvette's current podcast, Facing Evil, here:https://www.iheart.com/podcast/1119-facing-evil-98407485/Find Megan from Give Us Morgue here:https://giveusmorgue.com/Follow Give Us Morgue on:Instagram: https://www.instagram.com/giveusmorgue/-Audio editing by Jennifer Chen.-Incredible research assistance by Celi Riojas.-Sources:https://www.sleephealthjournal.org/article/S2352-7218(16)30119-X/fulltexthttps://stevehodel.com/2016/12/29/newly-discovered-man-ray-1969-lithograph-les-invendables-unsaleables-includes-surrealists-minotaur-homage-personal-friend-black-dahlia-killer-dr-george-hill-hodel/https://stevehodel.com/2019/09/22/fred-sextons-modernist-painting-death-of-monalita-becomes-fourth-post-black-dahlia-artwork-believed-linked-to-1947-murder-a-sexton-confession-on-canvas/https://www.ranker.com/list/120-days-of-sodom-acts/jacob-sheltonhttps://www.tate.org.uk/art/art-terms/s/surrealismGemma Taccogna: A Fred Sexton Survivor and Artist Extraordinairehttps://www.britannica.com/art/Surrealismhttps://www.theguardian.com/books/2016/oct/07/marquis-de-sade-120-days-of-sodom-published-classicGEORGE HODEL'S EXQUISITE CORPSE(S): BEYOND THE BLACK DAHLIADeath of a Dream: The Black Dahliahttps://www.wsj.com/articles/SB10001424052970203863204574346641329487698https://www.crimetraveller.org/2015/07/william-heirens-the-lipstick-killer/https://www.amazon.com/Exquisite-Corpse-Surrealism-Dahlia-Murder/dp/B000WZTZOUhttps://podcasts.apple.com/us/podcast/root-of-evil-the-true-story-of-the/id1450277129https://www.amazon.com/Black-Dahlia-Avenger-Steve-2012-03-13/dp/B01JXSPKTA

Long-duration shifts, variable shift scheduling, limited time off between shifts, and other factors are linked to fatigue in EMS shift workers. Odds of injury, error and adverse events are higher among U.S.-based EMS clinicians who report fatigue vs. those who do not. Come join us at the next PCRF Journal Club as we review a cluster-randomized trial that tests whether EMS clinicians randomized to receive tailored sleep health education would have improved sleep quality and less fatigue. Article: Patterson PD, Martin SE, Brassil BN, Hsiao WH, Weaver MD, Okerman TS, Seitz SN, Patterson CG, Robinson K. The Emergency Medical Services Sleep Health Study: A cluster-randomized trial. Sleep Health. 2022 Nov 10:S2352-7218(22)00181-4. doi: 10.1016/j.sleh.2022.09.013. Epub ahead of print. PMID: 36372657. Sites referenced: www.emsfatigue.org 412YinzerMedic.orgTo view the video, visit: https://youtu.be/YK7sCztJmhQ

We discuss a phase I study (CALM) of an allogeneic anti-CD19 CART-T product, using aprepitant (?) for pruritis from EGFR TKIs, and the widely discussed NordICC study on colonoscopy screening. CALM: https://doi.org/10.1016/S2352-3026(22)00245-9 Aprepitant vs. desloratidine: https://doi.org/10.1002/cncr.34474 NordICC: https://www.nejm.org/doi/full/10.1056/NEJMoa2208375 NordICC editorial: https://www.nejm.org/doi/full/10.1056/NEJMe2211595

Mleko jest smaczne, zdrowe i stanowi nasz pierwszy pokarm, ale jak to się stało, że możemy go pić także jako dorośli? Pszczoły są świetnymi zapylaczami na lądzie, ale czy ten proces odbywa się też w morskich głębinach, a jeśli tak to kto pełni funkcję owadów? W dzisiejszym odcinku podkastu Naukowo opowiem też o morderczych komórkach naszego ciała zabijających inne komórki bez wyraźnego powodu oraz o mini robocie zbudowanym z DNA. Przyjrzymy się też długości snu o dzieci i jak wpływa ona na ich długoterminowy rozwój. Zapraszam serdecznie!Jeśli uznasz, że warto wspierać ten projekt to zapraszam do serwisu Patronite, każda dobrowolna wpłata od słuchaczy pozwoli mi na rozwój i doskonalenie tego podkastu, bardzo dziękuję za każde wsparcie!Zapraszam również na Facebooka, Twittera i Instagrama, każdy lajk i udostępnienie pomoże w szerszym dotarciu do słuchaczy, a to jest teraz moim głównym celem :) Na stronie Naukowo.net znajdziesz więcej interesujących artykułów naukowych, zachęcam również do dyskusji na tematy naukowe, dzieleniu się wiedzą i nowościami z naukowego świata na naszym serwerze Discord - https://discord.gg/mqsjM5THXrŹródła użyte przy tworzeniu odcinka:Mills, A., Aissaoui, N., Maurel, D. et al. "A modular spring-loaded actuator for mechanical activation of membrane proteins". Nat Commun 13, 3182 (2022). https://doi.org/10.1038/s41467-022-30745-2E. Lavaut, M.-L. Guillemin, S. Colin, A. Faure, J. Coudret, C. Destombe, M. Valero. "Pollinators of the sea: A discovery of animal-mediated fertilization in seaweed". https://doi.org/10.1126/science.abo6661Evershed, R.P., Davey Smith, G., Roffet-Salque, M. et al. "Dairying, diseases and the evolution of lactase persistence in Europe". Nature (2022). https://doi.org/10.1038/s41586-022-05010-7Maayan Zohar-Fux, Aya Ben-Hamo-Arad, Tal Arad, Marina Volin, Boris Shklyar, Ketty Hakim-Mishnaevski, Lilach Porat-Kuperstein, Estee Kurant, Hila Toledano. "The phagocytic cyst cells in Drosophila testis eliminate germ cell progenitors via phagoptosis". https://doi.org/10.1126/sciadv.abm4937Zalecana ilość snu dla populacji dziecięcej: konsensus Amerykańskiej Akademii Medycyny Snu. Shalini Paruthi, MD, Lee J. Brooks, MD, Carolyn D'Ambrosio, MD, Wendy A. Hall, PhD, RN, Suresh Kotagal, MD, Robin M. Lloyd, MD, Beth A. Malow, MD, MS, Kiran Maski, MD, Cynthia Nichols, PhD, Stuart F. Quan, MD, Carol L. Rosen, MD, Matthew M. Troester, DO, and Merrill S. Wise, MD. "Recommended Amount of Sleep for Pediatric Populations: A Consensus Statement of the American Academy of Sleep Medicine". https://doi.org/10.5664/jcsm.5866University of Maryland School of Medicine. "Children Who Lack Sleep May Experience Detrimental Impact on Brain and Cognitive Development That Persists Over Time, UM School of Medicine Study Finds". https://www.newswise.com/articles/children-who-lack-sleep-may-experience-detrimental-impact-on-brain-and-cognitive-development-that-persists-over-time-um-school-of-medicine-study-finds?sc=rslaFan Nils Yang, PhD, Weizhen Xie, PhD, Ze Wang, PhD, "Effects of sleep duration on neurocognitive development in early adolescents in the USA: a propensity score matched, longitudinal, observational study", https://doi.org/10.1016/S2352-4642(22)00188-2

Febrile neutropenia updates on... Short duration antibiotics: https://doi.org/10.1016/S2352-3026(22)00145-4 Same-day pegfilgrastim: https://doi.org/10.2217/fon-2022-0365

Looking at some interesting articles as possible predictors of what to expect next in NSCLC and AML. NADIM: https://pubmed.ncbi.nlm.nih.gov/?term=35576508 Ven + Intensive Chemo: https://doi.org/10.1016/S2352-3026(22)00100-4

Der HAINS Talk Journal Club startet mit einer Doppelfolge aus dem Themenbereich der Notfallmedizin. Wir beschäftigen uns mit der RePHILL-Studie aus Großbritannien (https://doi.org/10.1016/S2352-3026(22)00040-0) zum prähospitalen Einsatz von Blutprodukten sowie der "Prague OHCA"-Studie (https://jamanetwork.com/journals/jama/article-abstract/2789313) zur ECPR. Bei uns diskutieren  Stephan Katzenschlager, wissenschaftlicher Mitarbeiter der Klinik für Anästhesiologie am UKHD und Prof. Erik Popp, Leiter der Sektion Notfallmedizin und Oberarzt der Klinik für Anästhesiologie am UKHD.

Joseph Mikhael, MD, and Irene Ghobrial, MD, discuss screening high-risk populations for early-stage multiple myeloma and new techniques to detect it. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/964336). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852672/ Prevalence of Monoclonal Gammopathies and Clinical Outcomes in a High-Risk US Population Screened by Mass Spectrometry: A Multicentre Cohort Study https://linkinghub.elsevier.com/retrieve/pii/S2352-3026(22)00069-2 Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM): A Population-Based Screening Study for Monoclonal Gammopathy of Undetermined Significance and Randomized Controlled Trial of Follow-up Strategies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128921/ International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma https://linkinghub.elsevier.com/retrieve/pii/S1470-2045(14)70442-5 The IMWG 2/20/20 Risk Stratification Model for Smoldering Multiple Myeloma https://multiplemyelomahub.com/medical-information/the-imwg-22020-risk-stratification-model-for-smoldering-multiple-myeloma

Drs Michael Saag and Constance Benson discuss antiretroviral therapy, maintenance, and switching. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963238). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2021 Update https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2021.pdf AIDS Clinical Trials Group https://actgnetwork.org/ Clarithromycin Therapy for Bacteremic Mycobacterium Avium Complex Disease https://www.acpjournals.org/doi/10.7326/0003-4819-121-12-199412150-00001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed UC San Diego Medical Center https://healthlocations.ucsd.edu/san-diego/200-w.-arbor-drive-hospital Highlights from the Ryan White Clinical Conference https://www.hiv.gov/blog/long-acting-injectables-hold-promise-maintaining-viral-suppression-and-preventing-hiv Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492356/ Key Considerations and Recommendations for Early (Acute and Recent) HIV Infection https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/early-acute-and-recent-hiv-infection?view=full Rising Rates of Recent Preexposure Prophylaxis Exposure Among Men Having Sex with Men Newly Diagnosed With HIV: Antiviral Resistance Patterns and Treatment Outcomes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876422/ Long-acting Cabotegravir Plus Rilpivirine for Treatment in Adults With HIV-1 Infection: 96-week Results of the Randomised, Open-Label, Phase 3 FLAIR Study https://linkinghub.elsevier.com/retrieve/pii/S2352-3018(20)30340-4

Wie kann man Kindern und Jugendlichen helfen, die wochen- oder sogar monatelang unter den Folgen einer SARS-CoV-2-Infektion leiden? Indem man sie ernst nimmt, erfährt Gastgeber Dr. Axel Enninger in der aktuellen Folge zum Thema „Long Covid bei Kindern”. Sein heutiger Gast ist Dr. Daniel Vilser, leitender Oberarzt im Bereich der Kinder-Kardiologie sowie Leiter der Long Covid-Ambulanz für Kinder an der Universitätsklinik Jena. „Unterm Strich bleibt Long Covid eine Ausschluss-Diagnose […] Das heißt, unser Anspruch ist es eine andere Erkrankung zu finden, denn alles andere können wir ja auch viel besser behandeln.” Das Vorgehen im Rahmen der Diagnostik ist dabei sehr umfangreich. Nicht nur Blutbild, Ultraschall, Kreislauf- und Belastungstests, auch die Psyche wird einbezogen und ein individuelles Therapiekonzept entwickelt. Eine kausale Therapie gibt es nicht, doch vieles kann helfen: klassische Rehabilitationsmaßnahmen und vor allem die Berücksichtigung der eigenen Belastbarkeit. Aber auch die Forschung hält spannende Ansätze für die Zukunft bereit. Hören Sie in diesem aktuellen Podcast… …warum man in Jena eine ganzheitliche Sprechstunde eingerichtet hat (1:47) …was gleich und was anders ist, als bei bekannten postviralen Fatigue-Syndromen (5:30) …wie häufig Long Covid tatsächlich vorkommt (6:58) …wie Schweregrad und Mosaiksteinchen bei der Diagnose helfen (12:45) …weshalb in der akuten Phase und bei „Ongoing Covid” Geduld gefragt ist (17:15) …wann sich die Patienten in der Spezial-Sprechstunde vorstellen sollten (21:19) …was zur Diagnostik gehört: Blutbild und Herz-Ultraschall bis psychologisches Assessment (22:53) …wie versucht wird eine individuelle Lösung zu finden – ohne Schwarz-Weiß (36:45) …was es mit Pacing und Crashes auf sich hat und was noch hilft (40:34) …welche Ansätze erforscht werden – es sind vielversprechende dabei (42:45) …was man den Patienten sagen kann, wie lang es noch dauert (48:27) …die „Do's”- und die „Don'ts” von Dr. Vilser (51:15) Weiterführende Links: https://www.uniklinikum-jena.de/kim4/Die+Klinik/Ambulanzen.html (Info zur Post-Covid- Ambulanz am Universitätsklinikum Jena) https://www.awmf.org/uploads/tx_szleitlinien/020- 027l_S1_Post_COVID_Long_COVID_2021-07.pdf (S1-Leitlinie Post-COVID/Long-COVID) Borch, L., Holm, M., Knudsen, M. et al. Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study. Eur J Pediatr (2022) https://doi.org/10.1007/s00431-021-04345-z Kikkenborg Berg S, Dam Nielsen S, Nygaard U, Bundgaard H, Palm P, Rotvig C, et al. Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study. The Lancet Child & Adolescent Health. 2022. https://doi.org/10.1016/S2352-4642(22)00004-9 Stephenson, T., Pinto Pereira, S., Shafran, R. et al. Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study https://doi.org/10.1016/S2352-4642(22)00022-0 Kontakte: Feedback zum Podcast? consilium@infectopharm.com Homepage zum Podcast: www.infectopharm.com/consilium/podcast/ Homepage InfectoPharm: www.infectopharm.com Disclaimer: Der consilium – Pädiatrie-Podcast dient der neutralen medizinischen Information und Fortbildung für Ärzte. Für die Inhalte sind der Moderator und die Gäste verantwortlich, sie unterliegen dem wissenschaftlichen Wandel des Faches. Änderungen sind vorbehalten.

This week we hype the seemingly negative impact of KIR2DS1/HLA-C2/C2 genotype on rituximab benefit in aggressive lymphomas. We also cover updates in breast cancer (pembrolizumab in TNBC; AIs in pre-menopausal women) and cervical cancer (cemiplimab). KIR & Rituximab: https://doi.org/10.1016/S2352-3026(21)00369-0 Keynote-522 Update w/ EFS analysis: https://www.nejm.org/doi/full/10.1056/NEJMoa2112651 Premenopausal Breast Cancer AIs vs. Tam Meta-Analysis: https://doi.org/10.1016/S1470-2045(21)00758-0 Cemiplimab in cervical cancer: https://www.nejm.org/doi/full/10.1056/NEJMoa2112187

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-259   Overview: Per CDC data, approximately 2.5 million Americans present each year to emergency departments with head injuries, and 15% of all high school students report experiencing at least one concussion. Current guidelines recommend physical and cognitive rest for 24-48 hours post-concussion with minimal guidance on screen time parameters. Recent evidence is emerging that supports avoidance of screen time and encouragement of aerobic activity as strategies to shorten and lessen post-concussion symptoms. Join us as we discuss 2 recent studies regarding screen-time and aerobic exercise that add critical information to best practice for reducing post-concussion symptoms.   Episode resource links: John J Leddy, Christina L Master, Rebekah Mannix, Douglas J Wiebe, Matthew F Grady, William P Meehan, Eileen P Storey, Brian T Vernau, Naomi J Brown, Danielle Hunt, Fairuz Mohammed, Andrea Mallon, Kate Rownd, Kristy B Arbogast, Adam Cunningham, Mohammad N Haider, Andrew R Mayer, Barry S Willer. Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial. The Lancet Child & Adolescent Health, 2021; DOI: 10.1016/S2352-4642(21)00267-4   Macnow T, Curran T, Tolliday C, et al. Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial. JAMA Pediatr. Published online September 07, 2021. doi:10.1001/jamapediatrics.2021.2782 https://jamanetwork.com/journals/jamapediatrics/article-abstract/2783638#graphical-abstract-tab   DePadilla L, Miller GF, Jones SE, Peterson AB, Breiding MJ. Self-reported concussions from playing a sport or being physically active among high school students—United States, 2017. MMWR Morb Mortal Wkly Rep. 2018;67(24):682-685. doi:10.15585/mmwr.mm6724a3   University at Buffalo. (2021, September 30). Aerobic exercise after a sport-related concussion speeds recovery in adolescent athletes, study suggests: Daily aerobic exercise significantly reduced the risk of prolonged recovery. ScienceDaily. Retrieved October 2, 2021 from www.sciencedaily.com/releases/2021/09/210930213654.htm   McCrory P ,Meeuwisse W,Dvorak J,etal. Consensus statement on concussion in sport—the 5th International Conference on Concussion in Sport held in Berlin, October 2016. Br J Sports Med. 2017;51(11):838-847. doi:10.1136/bjsports-2017- 097699   Centers for Disease Control and Prevention. Recovery from concussion. Centers for Disease Control and Prevention; 2019. Accessed October 12, 2020. https://www.cdc.gov/headsup/basics/ concussion_recovery.html. Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Richard Onorato  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-259   Overview: Per CDC data, approximately 2.5 million Americans present each year to emergency departments with head injuries, and 15% of all high school students report experiencing at least one concussion. Current guidelines recommend physical and cognitive rest for 24-48 hours post-concussion with minimal guidance on screen time parameters. Recent evidence is emerging that supports avoidance of screen time and encouragement of aerobic activity as strategies to shorten and lessen post-concussion symptoms. Join us as we discuss 2 recent studies regarding screen-time and aerobic exercise that add critical information to best practice for reducing post-concussion symptoms.   Episode resource links: John J Leddy, Christina L Master, Rebekah Mannix, Douglas J Wiebe, Matthew F Grady, William P Meehan, Eileen P Storey, Brian T Vernau, Naomi J Brown, Danielle Hunt, Fairuz Mohammed, Andrea Mallon, Kate Rownd, Kristy B Arbogast, Adam Cunningham, Mohammad N Haider, Andrew R Mayer, Barry S Willer. Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial. The Lancet Child & Adolescent Health, 2021; DOI: 10.1016/S2352-4642(21)00267-4   Macnow T, Curran T, Tolliday C, et al. Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial. JAMA Pediatr. Published online September 07, 2021. doi:10.1001/jamapediatrics.2021.2782 https://jamanetwork.com/journals/jamapediatrics/article-abstract/2783638#graphical-abstract-tab   DePadilla L, Miller GF, Jones SE, Peterson AB, Breiding MJ. Self-reported concussions from playing a sport or being physically active among high school students—United States, 2017. MMWR Morb Mortal Wkly Rep. 2018;67(24):682-685. doi:10.15585/mmwr.mm6724a3   University at Buffalo. (2021, September 30). Aerobic exercise after a sport-related concussion speeds recovery in adolescent athletes, study suggests: Daily aerobic exercise significantly reduced the risk of prolonged recovery. ScienceDaily. Retrieved October 2, 2021 from www.sciencedaily.com/releases/2021/09/210930213654.htm   McCrory P ,Meeuwisse W,Dvorak J,etal. Consensus statement on concussion in sport—the 5th International Conference on Concussion in Sport held in Berlin, October 2016. Br J Sports Med. 2017;51(11):838-847. doi:10.1136/bjsports-2017- 097699   Centers for Disease Control and Prevention. Recovery from concussion. Centers for Disease Control and Prevention; 2019. Accessed October 12, 2020. https://www.cdc.gov/headsup/basics/ concussion_recovery.html. Guest: Guest   Music Credit: Richard Onorato

We all know how commonly pediatric surgeons see patients with appendicitis and how frequently new literature is published on its management. Dr. Jose Campos helped us find some of the latest publications on appendicitis management and we discussed a few of the articles featured in this podcast. Hosts: Rodrigo Gerardo & Ellen Encisco Featured articles plus more: RIFT study group. Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study. April 2020. https://doi.org/10.1016/S2352-4642(20)30006-7 Unsdorfer KML, An JY, Binkovitz, LA. Pediatric appendiceal ultrasoun: maintaining accuracy, increasing determinacy and improving clinical outcomes following the introduction of a standardized reporting template. September 2020. https://doi.org/10.1007/s00247-020-04820-z Patkova B, Svenningsson A, et al. Nonoperative Treatment Versus Appendectomy for Acute Nonperforated Appendicitis in Children. June 2020. https://doi.org/10.1097/SLA.0000000000003646 Kashtan MA, Graham DA, et al. Ceftriaxone Combined With Metronidazole is Superior to Cefoxitin Alone in the Management of Uncomplicated Appendicitis in Children. March 2020. https://doi.org/10.1097/SLA.0000000000003704 Cameron DB, Anandalwar SP, et al. Development and Implications of an Evidence-based and Public Health-relevant Definition of Complicated Appendicitis in Children. May 2020. https://doi.org/10.1097/SLA.0000000000003059 Mennie N, Panabokke G, et al. Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial. August 2020. https://doi.org/10.1097/SLA.0000000000003732 Farr BJ, Ranstrom L, Mooney DP. Eliminating Opiate Prescribing for Children after Non-Perforated Appendectomy. June 2020. https://doi.org/10.1016/j.jamcollsurg.2020.03.023 See more articles on the StayCurrent app.

Promoting evidence-based antimicrobial stewardship for patients with immunocompromising conditions can be tricky when they're often excluded from clinical studies. Dr. Zahra Kassamali Escobar (@ZKEPharmD) explores this gray zone with Dr. Catherine Liu and Dr. Justine Ross (@abella_ross) References: Fluoroquinolone Prophylaxis  Bucaneve et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 2005; 353:977-87. DOI: 10.1056/NEJMoa044097  Cullen et al. Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med 2005; 353:988-98. DOI: 10.1056/NEJMoa050078  Drayson et al. Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicenter, double-blind, placebo-controlled, randomized, phase 3 trial. Lancet Oncology  2019; 20(12):1760-72. DOI: 10.1016/S1470-2045(19)30506-6 Satlin et al. Colonization with fluoroquinolone-resistant enterobacterales decreases the effectiveness of fluoroquinolone prophylaxis in hematopoietic cell transplant recipients. Clin Infect Dis 2021 May 6. doi: 10.1093/cid/ciab404.  Antibiotic Treatment and Microbiome Implications Aguilar-Guisado M, et al. Optimisation of empirical antimicrobial therapy in patients with haemotological malignancies and febrile neutropenia (How Long study): an open-label, randomized, controlled, phase 4 trial. Lancet Haematol. 2017 Dec;4(12):e573-83. doi: 10.1016/S2352-3026(17)30211-9. Shono et al. Gut microbiome injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer. 2018;18(5):283-95. doi: 10.1038/nrc.2018.10.  Weber et al. Microbiome disruption induced by early use of broad-spectrum antibiotics is an independent risk factor of outcome after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2017;23(5):845-52. doi: 10.1016/j.bbmt.2017.02.006  Pinato et al. Association of prior antibiotic treatment with survival and response to immune checkpoint inhibitor therapy in patients with cancer. JAMA Oncol. 2019;5(12):1774-78. doi:10.1001/jamaoncol.2019.2785   Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/

Deze opname is gemaakt voor de aanslag op Peter R. de Vries. Ladies and gentlemen, we got him! De mannen van Wester hebben deze aflevering Hugo de Jonge te gast in de podcast. Auke trekt natuurlijk weer het boetekleed aan, het gaat eventjes over vaccineren en mutaties, de druk van het zijn van de coronaminister het afgelopen jaar en de de carrière plannen Hugo de Jonge voor de komende jaren. Bronnen genoemd door Auke: - Bij de in dit paper onderzochte outbreaks op basisscholen in Engeland was bij 48% van de gevallen slechts het personeel besmet. En zowel basisscholen als kinderdagverblijven meegenomen was in 62% van de scholen een personeelslid de indexcase. Ismail, S., Saliba, V., Bernal, J., Ramsay, M., & Ladhani, S. (2021, March). SARS-CoV-2 infection and transmission in educational settings: a prospective, cross-sectional analysis of infection clusters and outbreaks in England. The Lancet Infectious Diseases, 21(3), 244-353. DOI: https://doi.org/10.1016/S1473-3099(20)30882-3 - In het volgende paper werd vastgesteld dat er geen bewijs was dat kinderen naar verhouding meer risico liepen voor de Britse variant van Covid-19 dan voor de oorspronkelijke variant van Covid-19. Brookman, S., Cook, J., Zucherman, M., Broughton, S., Harman, K., Gupta, A. (2021) Effects of the new SARS - CoV-2 variant B.1.1.7 on children and young people. The Lancet Child & Adolescents Health. 5(4), 9-10. DOI: https://doi.org/10.1016/S2352-4642(21)00030-4 Abonneer je op Pa en de Politiek. Pa en de Politiek is een productie van t-talks. Muziek: Cat Stevens - Father and Son

Over the last 50 years, advances in surgical procedures, clinical understandings and targeted treatments have changed the prospects of many cancer diagnoses from terminal to treatable. However, this progress is not evenly distributed across the many different types of cancer, and nowhere is that more keenly felt than in cancers affecting children.  How might the advances and insights in treating blood cancers benefit patients with brain tumours?To answer that question, I am speaking today with Dr David Walker and Dr Chris Halsey about their research connecting trials and treatments across disease types, for the benefit of all patients.Read more: http://dx.doi.org/10.1016/S2352-4642(19)30333-5

In November 2020, Dr Marina Landau published an article in the Journal of American Academy of Dermatology describing an unnerving newly identified complication: morphea-like lesions following Botox injections.In this week's Aesthetics Mastery Show, Dr Tim explores what can only be described as a 'dent' effect in patients' foreheads; unpacks the likely cause; and explains the practical steps practitioners can take to avoid causing the side effect in the first place.Here are the articles Dr Tim mentions in the Show, starting with Dr Landau's research:https://www.jaadcasereports.org/article/S2352-5126(20)30632-9/fulltexthttps://www.sciencedirect.com/science/article/pii/S0022354919300863https://www.jaadcasereports.org/article/S2352-5126(20)30445-8/pdfhttps://www.jaad.org/action/showPdf?pii=S0190-9622%2819%2932460-0Sign up to Dr Tim's free webinar about how to free yourself from complications anxiety: https://www.aestheticcomplications.com/live-training#complications #medicalaesthetics #aesthetics

It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration! GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music! Reference: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. PMID: 29032957. Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020 Jan;99(1):57-63. doi: 10.1007/s00277-019-03871-z. Epub 2019 Dec 6. PMID: 31811360. Visapää JP, Tillonen JS, Kaihovaara PS, et al. Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother. 2002 Jun;36(6):971-4. doi: 10.1345/aph.1A066. PMID: 12022894. Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018 May 1;75(5):566-572. doi: 10.1001/jamaneurol.2017.5144. PMID: 29482205; PMCID: PMC5885255. CPE details for GameChangers Podcast April 2021 Learning Objective: Discuss the evidence-based dosing of oral iron supplementation. 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information. Learn more about your ad choices. Visit megaphone.fm/adchoices

It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration! GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music! Reference: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. PMID: 29032957. Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020 Jan;99(1):57-63. doi: 10.1007/s00277-019-03871-z. Epub 2019 Dec 6. PMID: 31811360. Visapää JP, Tillonen JS, Kaihovaara PS, et al. Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother. 2002 Jun;36(6):971-4. doi: 10.1345/aph.1A066. PMID: 12022894. Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018 May 1;75(5):566-572. doi: 10.1001/jamaneurol.2017.5144. PMID: 29482205; PMCID: PMC5885255. CPE details for GameChangers Podcast April 2021 Learning Objective: Discuss the evidence-based dosing of oral iron supplementation. 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration! GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music! Reference: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. PMID: 29032957. Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020 Jan;99(1):57-63. doi: 10.1007/s00277-019-03871-z. Epub 2019 Dec 6. PMID: 31811360. Visapää JP, Tillonen JS, Kaihovaara PS, et al. Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother. 2002 Jun;36(6):971-4. doi: 10.1345/aph.1A066. PMID: 12022894. Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018 May 1;75(5):566-572. doi: 10.1001/jamaneurol.2017.5144. PMID: 29482205; PMCID: PMC5885255. CPE details for GameChangers Podcast April 2021 Learning Objective: Discuss the evidence-based dosing of oral iron supplementation. 0107-0000-21-158-H01-P 0.2 CEU/2 Hrs (Knowledge) Initial Release Date: 04/06/21 Expiration Date: 03/02/24 Additional CPE information is located at https://www.ceimpact.com/podcast  See omnystudio.com/listener for privacy information.

It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration!GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music!Reference: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. PMID: 29032957.Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020 Jan;99(1):57-63. doi: 10.1007/s00277-019-03871-z. Epub 2019 Dec 6. PMID: 31811360.Visapää JP, Tillonen JS, Kaihovaara PS, et al. Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother. 2002 Jun;36(6):971-4. doi: 10.1345/aph.1A066. PMID: 12022894.Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018 May 1;75(5):566-572. doi: 10.1001/jamaneurol.2017.5144. PMID: 29482205; PMCID: PMC5885255.CPE details for GameChangers Podcast April 2021Learning Objective: Discuss the evidence-based dosing of oral iron supplementation.0107-0000-21-158-H01-P0.2 CEU/2 Hrs (Knowledge)Initial Release Date: 04/06/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

Today we interview Dr. Ghulam Rehman Mohyuddin of Kansas University Medical Center on his new paper out now in The Lancet Haematology titled "Quality of control groups in randomised trials of multiple myeloma enrolling in the USA: a systematic review". Control Groups: doi.org/10.1016/S2352-3026(21)00024-7 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

We start this week's episode by revisiting our discussion from last week on the PNAS study on racial concordance and birthing mortality. We continue our theme of critical appraisal by then tearing apart the recent paper published in BMJ titled "Two metres or one: what is the evidence for physical distancing in covid-19?" and its inability to support its colorful figures. We end the monologue with a few thoughts on academics who somehow author one paper a week. Finally, we turn to the last two segments of the show: the first is a discussion with Dr. Bishal Gyawali on his new paper out now in The Lancet Haematology titled "A survey in Nepalese patients with acute leukaemia: a starting point for defining financial toxicity of cancer care in low-income and middle-income countries" and the second is Journal Club with a Fellow, where we interview Dr. Justine Ryu on a paper published in The Lancet titled "Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial". Racial Concordance: doi.org/10.1073/pnas.1913405117 COVID-19 Risk: doi.org/10.1136/bmj.m3223 Financial Toxicity: doi.org/10.1016/S2352-3026(20)30258-1 HALT-IT: doi.org/10.1016/S0140-6736(20)30848-5 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

While this is a topic best covered with case examples, we do our best to provide the basics in 20 minutes. Experienced clinicians may not be aware of the How Long study briefly discussed in this episode: https://doi.org/10.1016/S2352-3026(17)30211-9

This week we respond to some listener feedback from Dr. Christopher Booth and use it to talk about how to be the best hematologist-oncologist. We also discuss the SADAL study on Selinexor for patients with relapsed refractory diffuse large B-cell lymphoma, as published in The Lancet Haematology. Finally, we interview Drs. Eva Katsoulakis and Michael Kelley on their recent paper out in the Journal of Clinical Oncology: Precision Oncology, titled "Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program". Selinexor: doi.org/10.1016/S2352-3026(20)30120-4 Annotation Services: doi.org/10.1200/PO.19.00118 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: https://www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Cardiovascular Events with CHOP/RCHOP in Non-Hogkin's -Hot-of-the-Press Dr RR Baliga's 'Got Knowledge Doc' PODCASTS for Physicians Published in Lancet Hematology Online March 2nd, 2020 https://doi.org/10.1016/S2352-3026(20)30031-4 Not Medical Advice or Opinion

This week we delve into global pediatric cardiology and review a massive and important work from the Global Burden of Disease study group assessing the trends in congenital heart disease in the world from lower income nations to higher. How has the prevalence of congenital heart disease changed over the past 30 years? How are countries faring in their treatment of congenital heart disease? What are some strategies to address global inequities in care? We discuss these and other questions with the corresponding author of this work, Professor Craig Sable of George Washington University. doi: 10.1016/S2352-4642(19)30402-X

This week we delve into global pediatric cardiology and review a massive and important work from the Global Burden of Disease study group assessing the trends in congenital heart disease in the world from lower income nations to higher. How has the prevalence of congenital heart disease changed over the past 30 years? How are countries faring in their treatment of congenital heart disease? What are some strategies to address global inequities in care? We discuss these and other questions with the corresponding author of this work, Professor Craig Sable of George Washington University. doi: 10.1016/S2352-4642(19)30402-X

This episode is designed to encourage you to take actions to improve your health, fitness and wellness by making changes to your lifestyle, so you can become more fit for life, and thereby move towards your new normal. I tell you about: One recently published scientific paper on sleep I think is worth knowing about Four other recently published scientific papers on sleep you might find worth reading Some books I’ve been reading and recommend for you Some podcasts I’ve been listening to and recommend for you How I went with the 4 challenges I made in the last New Normal in Action episode I invite you to listen to the scientific evidence, experience-based information and real-life stories on this show so you might make choices in leading your life to help you live vibrantly, happily, purposefully, for a long time, disease-free, and above all with a low risk of ever being admitted to the Intensive Care Unit, the place in the hospital I work. Perhaps you might consider a 28 day challenge (or even a 7 day one) yourself. Small steps are important. Incremental change, particularly around habits, can be very beneficial for your health and happiness.   Live well, feel well, do well.   Dr Andrew Davies   ------------------------------------   About the New Normal Project podcast: The podcast is aimed to inspire and empower you to live a life of optimal health, fitness and wellness, by hearing scientific evidence, experience-based information and real-life stories in the areas of the lifestyle pillars such as nutrition, exercise, mindfulness, sleep, connection and purpose. You’ll hopefully glean insights to help you to consider making choices about your daily habits so you become more healthy, fulfilled and conscious. Although I’m a doctor this is not medical advice as I don’t know your personal circumstances or your health conditions. Please see this as general information for you to consider, and then to learn more about, so you can discuss it with your doctor.   ------------------------------------   Links to people and other resources (in order of mentioning) Doctors For Nutrition seminar “The Heart of The Matter” featuring Dr Kim Williams Dr Kim Williams Movie “The Game Changers” Movie “Eating You Alive” Movie “What The Health” Scientific paper on sleep duration healthy diet scores and meal patterns J Clin Sleep Med. 2020 Jan 15; 16(1):9-18. doi: 10.5664/jcsm.8112. EpiHealth study Scientific paper on sleep duration and hand guns Sleep Health. 2020 Jan 13. pii: S2352-7218(19)30259-1. doi: 10.1016/j.sleh.2019.11.008. Scientific paper on sleep health and depression Compr Psychiatry. 2019 Dec 5; 97:152151. doi: 10.1016/j.comppsych.2019.152151. Scientific paper on childhood obesity and sleep timing behaviour J Clin Sleep Med. 2020 Jan 15; 16(1):129-136. doi: 10.5664/jcsm.8080. Scientific paper on "Sleep Is Essential" J Clin Sleep Med. 2020 Jan 15; 16(1):1-2. doi: 10.5664/jcsm.8156. Book “Born To Run” (by Christopher McDougall) Book “Let’s Do This” (by Andy Ramage) Book “Feel Better in 5” (by Rangan Chaterjee) Feel Better Live More Podcast Rich Roll Podcast Rich Roll Podcast with Rangan Chaterjee Feel Better Live More podcast with Rich Roll Rich Roll Podcast with Chadd Wright Rich Roll Podcast with Kelly McGonigal Rich Roll Podcast with Neal Barnard Plant Proof podcast with Sean Ryan Plant-Strong podcast Book “How Not To Diet” (by Michael Greger) Book “Blue Zones” (by Dan Buettner) Phil Dobson   Links related to New Normal Project podcast resources New Normal Project podcast (NNP #2) with Rich Roll & Julie Piatt New Normal Project podcast (NNP #43) with Kim Williams New Normal Project podcast (NNP #45) with Neal Barnard New Normal Project podcast (NNP #46) with Andy Ramage New Normal Project podcast New Normal Project website New Normal Project on Facebook New Normal Project on Instagram: @newnormalproject New Normal Project on Twitter: @newnormalproj Email Andrew Davies Andrew Davies on Instagram: @andrewdavies66 Andrew Davies on Twitter: @andrewdavies66 Andrew Davies on Facebook Subscribe to the New Normal Project newsletter

In today's World Aids Day extravaganza, Annie and Carla interview Asha Persson and Christy Newman, Martin Holt and Limin Mao covering a whole range of issues and cutting-edge research. Timestamps 00:10 - 20:41 Asha Persson and Christy Newman 20:41 - 45:43 Martin Holt 45:43 - 58:05 Limin Mao Links “So Much Is at Stake”: Professional Views on Engaging Heterosexually Identified Men who Have Sex with Men with Sexual Health Care in Australia: https://link.springer.com/article/10.1007%2Fs13178-017-0291-z Challenging Perceptions of “Straight” Heterosexual Men Who Have Sex with Men and the Cultural Politics of Sexual Identity Categories: https://journals.sagepub.com/doi/abs/10.1177/1097184X17718586?journalCode=jmma StraightMSM Study: Heterosexually-Identified Men Who Have Sex With Men Project: https://csrh.arts.unsw.edu.au/research/projects/straight-msm/ Sydney Gay Asian Men Survey: https://csrh.arts.unsw.edu.au/media/CSRHFile/20156_Sydney_Gay_Asian_Men_Survey.pdf Lancet HIV paper on uptake/impact of PrEP: https://doi.org/10.1016/S2352-3018(18)30072-9 Stigma Indicators Monitoring Project: https://csrh.arts.unsw.edu.au/research/projects/stigma-indicators/ For more info: csrh.arts.unsw.edu.au/research/podca…carla-treloar/

In today's World Aids Day extravaganza, Annie and Carla interview Martin Holt covering a whole range of issues and cutting edge research. Links Lancet HIV paper on uptake/impact of PrEP: https://doi.org/10.1016/S2352-3018(18)30072-9 Stigma Indicators Monitoring Project https://csrh.arts.unsw.edu.au/research/projects/stigma-indicators/ For more info: https://csrh.arts.unsw.edu.au/research/podcast-speakeasy-with-annie-madden-and-carla-treloar/

Here we talk about regenerative medicine and how far the field has come! Vacanti Mouse: https://en.wikipedia.org/wiki/Vacanti_mouse Growing the human heart: https://www.popsci.com/scientists-grow-transplantable-hearts-with-stem-cells Anthony Atala and bladder transplants: http://www.wakehealth.edu/News-Releases/2006/Wake_Forest_Physician_Reports_First_Human_Recipients_of_Laboratory-Grown_Organs.htm 3D bioprinting companies: https://3dprint.com/88792/3d-bioprinting-companies/ 3D printed tibia for Reuben Lichter: https://www.brisbanetimes.com.au/national/queensland/gold-coast-man-receives-3d-printed-shinbone-in-world-first-surgery-20170908-p4yvsx.html 3D printed ears: https://3dprintingindustry.com/news/china-researchers-construct-artificial-ears-using-3d-printing-tissue-engineering-128192/ http://www.ebiomedicine.com/article/S2352-3964(18)30016-1/abstract