Podcasts about Annals

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/latin-american-studies

In this episode of the Glowing Older podcast, host Nancy Griffin interviews Dr. Kenneth Pelletier, a clinical professor of medicine and psychiatry at UCSF, about the science of longevity and the role of epigenetics. Dr. Pelletier shares insights into the importance of healthspan over lifespan, and the impact of diet, stress, exercise, and social support on longevity. He also discusses the potential and limitations of biohacking and the growing field of integrative medicine. About Dr. Pelletier Kenneth R. Pelletier, PhD, MD is a Clinical Professor of Medicine, Department of Medicine; Department of Family and Community Medicine; and Department of Psychiatry at the University of California School of Medicine (UCSF) in San Francisco; and a Clinical Professor of Medicine in the Department of Medicine and Department Family and Community Medicine at the University of Arizona School of Medicine in Tucson. At the present time, Dr. Pelletier is a medical and business consultant to the US Department of Health and Human Services, the World Health Organization (WHO), the National Business Group on Health, the Federation of State Medical Boards, the Wild Dolphin Project, and major corporations including Cisco, IBM, American Airlines, Prudential, Dow, Disney, Ford, Mercer, Merck, Pepsico, Ford, Pfizer, Walgreens, NASA, Microsoft ENCARTA, Blue Cross/Blue Shield, United Healthcare, Health Net, the Pasteur Institute of Lille, France, the Alpha Group of Mexico, and the Singapore Ministry of Health. He also serves on the boards of the Rancho la Puerta (Mexico), Nova Institute, Fries Foundation, American Institute of Stress (AIS), American Journal of Health Promotion (AJHP), as a Founding Board Member of the American Board of Integrative Medicine (ABOIM), and as a peer reviewer for the Journal of the American Medical Association (JAMA), the Journal of Occupational and Environmental Medicine (JOEM), Annals of Internal Medicine, Health Affairs, and webMD.  Dr. Pelletier is listed in Who's Who in America and in Who's Who in the World. He has been featured on ABC World News, the Today program, Good Morning America, Dr Oz, the CBS Evening News, 48 Hours, the McNeil-Lehrer Newshour, CNN, FOX News, and CBS Sunday Morning.Dr. Pelletier is the author of 15 major books including the international bestseller Mind as Healer, Mind as Slayer; Holistic Medicine: From Stress to Optimum Health; Longevity: Fulfilling Our Biological Potential; Healthy People in Unhealthy Places; Stress and Fitness at Work; Sound Mind – Sound Body: A New Model for Lifelong Health; The Best Alternative Medicine: What Works? What Does Not?; Stress Free for Good: Ten Scientifically Proven Life Skills for Health and Happiness; New Medicine: How to Integrate Conventional and Alternative Medicine for the Safest and Most Effective Treatment and Change Your Genes – Change Your Life: Creating Optimal Health with the New Science ofEpigenetics.Key TakeawaysEpigenetics is a relatively new science, developed in the last 15 years. Epigenetics are all of the influences that determine our health, wellbeing, and life expectancy after the sperm and ovum unite. Epigenetics plays a crucial role in determining health and life expectancy – 95 % of health, illness, and life expectancy are due to factors other than our genes. The role of diet, stress, physical activity and social support significantly influence genetic expression.There are no longitudinal studies for biohacking. Don'tgo into the periphery and engage in questionable practices. Sort hope from hype.Equal criteria for evaluating the outcomes of alternative and conventional medicine must be applied; both should be held to the same rigorous scientific standards to ensure their acceptability and effectiveness.

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/world-affairs

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/american-studies

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/eastern-european-studies

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/politics-and-polemics

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices

A podcast from Cornell University's Brooks School of Public Policy Center on Global Democracy About the Podcast Each week, co-hosts Rachel Beatty Riedl and Esam Boraey bring together leading scholars, policymakers, and practitioners to explore the challenges and possibilities facing democracy around the world. Produced by Cornell's Center on Global Democracy, Democratic Dialogues bridges academic research with real-world debates — from democratic backsliding and authoritarian resurgence to civic resistance, renewal, and reform. We look at new books, groundbreaking articles, and the ideas reshaping how we understand and practice democracy today. Listen on YouTube, NBN, or wherever you get your podcasts. Episode 1 Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries This week, we feature an episode with Kenneth Roberts, Jennifer McCoy, and Murat Somer, joining co-hosts Rachel Riedl and Esam Boraey to discuss their collaborative article, “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” recently published in The Annals of the American Academy of Political and Social Science. Together, they unpack how democracies don't collapse overnight, but instead erode through different pathways — from executive aggrandizement to elite collusion — and how societies can resist or even partially recover. The conversation examines how these dynamics unfold in contexts as varied as Latin America, Turkey, Hungary, and the United States, and what practical lessons citizens and policymakers can draw today. This is an essential conversation for understanding how democracies falter, and how collective action, civic mobilization, and institutional renewal can push them back from the brink. Books, Links, & Articles “Pathways of Democratic Backsliding, Resistance, and (Partial) Recoveries,” Annals of the American Academy of Political and Social Science (2025) Jennifer McCoy & Murat Somer, Pernicious Polarization and Its Global Impact Kenneth Roberts, Populism, Political Mobilization, and the Latin American Left Rachel Beatty Riedl, Authoritarian Origins of Democratic Institutions in Africa Upcoming Episodes Our next episode features Susan C. Stokes (University of Chicago) discussing her book The Backsliders: Why Leaders Undermine Their Own Democracies. Stay tuned for an in-depth conversation on why democratic leaders sometimes turn against the institutions that empower them — and what can be done to safeguard democracy in an era of uncertainty. Subscribe and follow us on YouTube and social media for new releases every month. Learn more about your ad choices. Visit megaphone.fm/adchoices

Over 3 million clinicians around the world depend on UpToDate to guide patient care, and now the gold standard in clinical decision support is integrating generative AI. But in a world where AI models often hallucinate, how do you build something that doctors can actually trust?In this episode, Halle talks with Dr. Holly Urban, VP of Business Development and Strategy at Wolters Kluwer Health, about UpToDate Expert AI, a new tool trained exclusively on UpToDate's physician-authored content — not the open internet — and what it means for the future of medicine.We cover:

In episode 65 we discuss varenicline and bupropion for alcohol use disorder.  Söderpalm B, Lidö H, Franck J, Håkansson A, Lindqvist D, Heilig M, Guterstam J, Samuelson M, Askerup B, Wallmark-Nilsson C, de Bejczy A. Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310.     We also discuss medical marijuana for anxiety in Pennsylvania, and RFK's embrace of psychedelic therapy.  Annals of Internal Medicine: Medical Cannabis Certifications After Pennsylvania Added Anxiety Disorders as a Qualifying Condition  Annals of Internal Medicine: High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes: A Systematic Review  MedPageToday: Will RFK Jr.'s Push for Psychedelic Therapy Help or Hamper the Emerging Field?  ---  This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.  CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/   ---  Original theme music: composed and performed by Benjamin Kennedy  Audio editing: Michael Bonanno  Executive producer: Dr. Patrick Beeman  A podcast from Ars Longa Media  ---  This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.   ---  The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.  Email: addictionmedicinejournalclub@gmail.com   Facebook: @AddictionMedJC  Facebook Group: Addiction Medicine Journal Club  Instagram: @AddictionMedJC   Threads: @AddictionMedJC  YouTube: addictionmedicinejournalclub   Twitter/X: @AddictionMedJC    ---  Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices

Did you know that congenital heart defects (CHDs) affect nearly 40,000 babies born in the United States every year? On this episode, Pediatric Cardiologist Dr. Melissa Lefebvre and medical student Marina Hashim discuss the evaluation and management of common acyanotic congenital heart conditions. Specifically, they will: Review the classification of CHDs as cyanotic versus acyanotic. Discuss the pathophysiology of the three most common acyanotic CHDs – ASD, PDA, and VSD. Describe early clinical findings and use of diagnostic tools. Cover management options, ranging from spontaneous closure to surgical intervention. Explore prognosis and long-term outcomes on physical activity, neurodevelopment, and overall health. Special thanks to Dr. Rebecca Yang and Dr. Abeer Hamdy for peer reviewing this episode. CME available free with sign up: Link Coming Soon! References: Dimopoulos, K., Constantine, A., Clift, P., & Condliffe, R. (2023). Cardiovascular complications of down syndrome: Scoping review and expert consensus. Circulation, 147(5). https://doi.org/10.1161/CIRCULATIONAHA.122.059706   Dugdale, D. C. (Ed.). (n.d.). Pediatric heart surgery - discharge. Mount Sinai. Retrieved April 26, 2024, from https://www.mountsinai.org/health-library/discharge-instructions/pediatric-heart-surgery-discharge   Eckerström, F., Nyboe, C., Maagaard, M., Redington, A., & Hjortdal, V. (2023). Survival of patients with congenital ventricular septal defect. European Heart Journal,  44 (1,1), 54-61. https://doi.org/10.1093/eurheartj/ehac618   Heart MRI. (2022, July 24). Cleveland Clinic. Retrieved April 19, 2024, from https://my.clevelandclinic.org/health/diagnostics/21961-heart-mri Leihao, S., Yajiao, L., Yunwu, Z., Yusha, T., Yucheng, C., & Lei, C. (2023). Heart-brain axis: Association of congenital heart abnormality and brain diseases. Frontiers in Cardiovascular Medicine, 10. https://doi.org/10.3389/fcvm.2023.1071820 Meyer, K. (Ed.). (2022, May 1). What is a ventricular septal defect (VSD)? Cincinnati Children's. Retrieved March 12, 2024, from https://www.cincinnatichildrens.org/health/v/vsd Minette, M. S., & Sahn, D. S. (2006). Ventricular septal defects. Circulation, 114(20). https://doi.org/10.1161/CIRCULATIONAHA.106.618124 Mussatto, K. A., Hoffmann, R. G., Hoffman, G. M., Tweddell, J. S., Bear, L., Cao, Y., & Brosig, C. (2014). Risk and prevalence of developmental delay in young children with congenital heart disease. Pediatrics, 133(3), e570–e577. https://doi.org/10.1542/peds.2013-2309 Pruthi, S. (Ed.). (2022, October 21). Ventricular septal defect (VSD). Mayo Clinic. Retrieved April 9, 2024, from https://www.mayoclinic.org/diseases-conditions/ventricular-septal-defect/symptoms-causes/syc-20353495     Right heart catheterization. (2022, July 24). Cleveland Clinic. Retrieved April 19, 2024, from https://my.clevelandclinic.org/health/diagnostics/21045-right-heart-catheterization Shah, S., Mohanty, S., Karande, T., Maheshwari, S., Kulkarni, S., & Saxena, A. (2022). Guidelines for physical activity in children with heart disease. Annals of pediatric cardiology, 15(5-6), 467–488. https://doi.org/10.4103/apc.apc_73_22 Sigmon, E., Kellman, M., Susi, A., Nylund, C., & Oster, M. (2019). Congenital heart disease and Autism: A case-control study. Pediatrics, 144(5). https://doi.org/10.1542/peds.2018-4114 Thacker, D. (Ed.). (2022, January 1). Ventricular septal defect (VSD). Nemours Kids Health. Retrieved April 10, 2024, from https://kidshealth.org/en/parents/vsd.html   Tierney, S., & Seda, E. (2020). The benefit of exercise in children with congenital heart disease. Current Opinion in Pediatrics, 32(5), 626-632. https://doi.org/10.1097/MOP.0000000000000942  Ventricular septal defects (VSD). (2021, November 9). Cleveland Clinic. Retrieved April 2, 2024,from https://my.clevelandclinic.org/health/diseases/17615-ventricular-septal-defects-vsd    Ventricular septal defect surgery for children. (n.d.). Johns Hopkins Medicine. Retrieved April 11,2024, from https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/ventricular-septal-defect-surgery-for-children#:~:text=During%20this%20surgery%2C%20a%20surgeon,the%20hole%20between%20the%20ventricles Wernovsky, G., & Licht, D. J. (2016). Neurodevelopmental Outcomes in children with congenital heart disease - what can we impact?. Pediatric Critical Care Medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 17(8 Suppl 1), S232–S242. https://doi.org/10.1097/PCC.0000000000000800

Autism isn't new, but our understanding of it has changed dramatically. It's now recognized as a broad neurodevelopmental spectrum that shapes how millions of people perceive, process, and interact with the world. In this episode, we explore what autism is AND isn't, from its earliest signs in infancy to its deep genetic roots, and why misinformation about it continues to spread. We speak with three remarkable experts leading the field in early detection, genetics, and public education: DR. AMI KLIN, PhD, Director of the Marcus Autism Center at Emory University and a pioneer in early autism research, whose work shows autism can be identified in babies as young as two months old. DR. JOSEPH BUXBAUM, PhD, Director of the Seaver Autism Center at Mount Sinai and a global leader in autism genetics, uncovering hundreds of genes linked to the condition. DR. ANDREA LOVE, immunologist, microbiologist, and founder of ImmunoLogic, known for her clear, evidence-based communication about vaccines, immunity, and autism myths. Together, we discuss: • What autism really is, and how the definitions have evolved • How it develops in infancy (and why early diagnosis can be so critical) • The powerful genetic evidence behind autism • The persistence of vaccine myths, and how misinformation spreads • How technology like eye-tracking can detect autism early • The rise of “profound autism” and what it means for families • The future of genetics-based treatments and therapy Whether you're autistic yourself, a parent navigating a new diagnosis, or simply seeking understanding, we're thrilled to share this extensive, in-depth episode with you. This is... Your Brain On Autism. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ ‘Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Autism' • SEASON 6 • EPISODE 1 LINKS Dr. Ami Klin at Emory University: https://ctsn.emory.edu/faculty/klin-ami.html Dr. Ami Klin at Marcus Autism Center: https://www.marcus.org/about-marcus-autism-center/meet-our-leadership/ami-klin  Dr. Joseph Buxbaum at Mount Sinai: https://profiles.icahn.mssm.edu/joseph-d-buxbaum  Dr. Andrea Love's website: https://www.immunologic.org/ Dr. Andrea Love on Instagram: https://www.instagram.com/dr.andrealove  REFERENCES Autism Spectrum Disorder: A Review. JAMA, 2023. https://jamanetwork.com/journals/jama/article-abstract/2800182  Is There a Bias Towards Males in the Diagnosis of Autism? A Systematic Review and Meta-Analysis. https://link.springer.com/article/10.1007/s11065-023-09630-2  Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. https://pubmed.ncbi.nlm.nih.gov/38592388/  Eye-Tracking–Based Measurement of Social Visual Engagement Compared With Expert Clinical Diagnosis of Autism. https://jamanetwork.com/journals/jama/fullarticle/2808996  Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. https://www.nature.com/articles/s41588-022-01104-0  Rare coding variation illuminates the allelic architecture, risk genes, cellular expression patterns, and phenotypic context of autism. https://www.medrxiv.org/content/10.1101/2021.12.20.21267194v1  Andrew Wakefield and the fabricated history of the alleged vaccine-autism link. https://geneticliteracyproject.org/2024/04/29/andrew-wakefield-and-the-fabricated-history-of-the-alleged-vaccine-autism-link/ VACCINES & AUTISM 1. Major Cohort Studies Hviid et al., 2019 – Annals of Internal Medicine A nationwide study of 657,461 Danish children found no increased risk of autism in vaccinated children compared to unvaccinated peers — even among those with risk factors such as a sibling with autism. Ann Intern Med. 2019;170(8):513–520 Madsen et al., 2002 – New England Journal of Medicine In 537,303 Danish children, researchers found no difference in autism rates between vaccinated and unvaccinated groups, and no relationship with age, timing, or date of vaccination. NEJM. 2002;347:1477–1482 Jain et al., 2015 – Journal of the American Medical Association (JAMA) A U.S. cohort of 95,727 children — including those with siblings with autism — showed no link between MMR vaccination and autism risk, even in genetically predisposed children. JAMA. 2015;313(15):1534–1540 Madsen et al., 2003 – JAMA A study of 467,450 Danish children found no relationship between thimerosal-containing vaccines and autism. JAMA. 2003;290(13):1763–1766 DeStefano et al., 2022 – Vaccine A retrospective cohort of over 500,000 U.S. children with ASD found no increase in adverse events or worsening of autism-related symptoms following vaccination. Vaccine. 2022;40(16):2391–2398 2. Population-Level Epidemiologic Evidence Taylor et al., 1999 – The Lancet One of the earliest large epidemiological studies found autism prevalence was the same in vaccinated and unvaccinated children, and the age of onset was unrelated to the timing of MMR vaccination. Read: Lancet. 1999;353(9169):2026–2029 Institute of Medicine (U.S.) Immunization Safety Review, 2011 A global review of studies from the U.S., Denmark, Sweden, and the U.K. concluded there is no causal relationship between vaccination status and autism, and no plausible biological mechanism linking vaccines (including thimerosal) to ASD. Read: National Academies Press / PubMed 20669467 3. Systematic Reviews and Meta-Analyses Taylor et al., 2014 – Vaccine A comprehensive meta-analysis of 10 studies including over 1.2 million children found no association between vaccination and autism or ASD. Vaccine. 2014;32(29):3623–3629 Maglione et al., 2014 – Pediatrics Review of 67 high-quality studies covering the full U.S. immunization schedule concluded that vaccines are safe, adverse events are rare, and there is no link to autism, type 1 diabetes, or other chronic conditions. Pediatrics. 2014;134(2):325–337 Parker et al., 2004 – Pediatrics Systematic review of 10 primary studies examining thimerosal exposure found no relationship between vaccines and ASD. Authors noted that studies showing an association were methodologically flawed or biased, while robust studies consistently showed safety. Pediatrics. 2004;113(6):1904–1910 Offit & Hackett, 2003 – Clinical Infectious Diseases Review of immunology and epidemiology concluded that claims that vaccines “overwhelm” or “damage” the immune system are not biologically plausible based on how the immune system actually functions. Clin Infect Dis. 2003;46(9):1450–1456

Dr. Centor revisits information included in the Annals of Internal Medicine supplement "What You May Have Missed in 2024."

¿Qué hacemos cuando el brazo no se mueve? En este episodio hablamos de ese punto de partida que tanto intimida: el miembro superior completamente pléjico tras un ictus. A partir de la experiencia clínica y la neurofisiología más actual, exploramos cómo comenzar a activar un brazo desde cero. Abordamos estrategias basadas en evidencia como el trabajo en carga en cadena cinética cerrada, la electroestimulación funcional multicanal, el uso de herramientas como el PANAt Laptool, el entrenamiento bilateral y los paradigmas de uso forzado inspirados en Forced-Use Utley/Woll. También repasamos el papel del entrenamiento con soporte de peso, ese enfoque nacido de los laboratorios de Dewald y Ellis que ha cambiado la forma de entender la sinergia flexora. Un episodio para fisioterapeutas y terapeutas ocupacionales que quieren comprender no solo qué hacer, sino por qué hacerlo. Referencias del episodio: 1. Arya, K. N., & Pandian, S. (2014). Interlimb neural coupling: implications for poststroke hemiparesis. Annals of physical and rehabilitation medicine, 57(9-10), 696–713. https://doi.org/10.1016/j.rehab.2014.06.003 (https://pubmed.ncbi.nlm.nih.gov/25262645/). 2. Cauraugh, J. H., & Summers, J. J. (2005). Neural plasticity and bilateral movements: A rehabilitation approach for chronic stroke. Progress in neurobiology, 75(5), 309–320. https://doi.org/10.1016/j.pneurobio.2005.04.001 (https://pubmed.ncbi.nlm.nih.gov/15885874/). 3. Chen, S., Qiu, Y., Bassile, C. C., Lee, A., Chen, R., & Xu, D. (2022). Effectiveness and Success Factors of Bilateral Arm Training After Stroke: A Systematic Review and Meta-Analysis. Frontiers in aging neuroscience, 14, 875794. https://doi.org/10.3389/fnagi.2022.875794 (https://pubmed.ncbi.nlm.nih.gov/35547621/). 4. Ellis, M. D., Carmona, C., Drogos, J., & Dewald, J. P. A. (2018). Progressive Abduction Loading Therapy with Horizontal-Plane Viscous Resistance Targeting Weakness and Flexion Synergy to Treat Upper Limb Function in Chronic Hemiparetic Stroke: A Randomized Clinical Trial. Frontiers in neurology, 9, 71. https://doi.org/10.3389/fneur.2018.00071 (https://pubmed.ncbi.nlm.nih.gov/29515514/) 5. Jang, S. H., & Lee, S. J. (2019). Corticoreticular Tract in the Human Brain: A Mini Review. Frontiers in neurology, 10, 1188. https://doi.org/10.3389/fneur.2019.01188 (https://pubmed.ncbi.nlm.nih.gov/31803130/). 6. Khan, M. A., Fares, H., Ghayvat, H., Brunner, I. C., Puthusserypady, S., Razavi, B., Lansberg, M., Poon, A., & Meador, K. J. (2023). A systematic review on functional electrical stimulation based rehabilitation systems for upper limb post-stroke recovery. Frontiers in neurology, 14, 1272992. https://doi.org/10.3389/fneur.2023.1272992 (https://pubmed.ncbi.nlm.nih.gov/38145118/). 7. Langhorne, P., Wu, O., Rodgers, H., Ashburn, A., & Bernhardt, J. (2017). A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial. Health technology assessment (Winchester, England), 21(54), 1–120. https://doi.org/10.3310/hta21540 (https://pubmed.ncbi.nlm.nih.gov/28967376/). 8. Michielsen, M., Cornelis, L., Cruycke, L., De Smedt, A., Fobelets, M., Putman, K., Vander Plaetse, M., Verheyden, G., & Meyer, S. (2025). Arm-hand BOOST (AHA-BOOST) therapy to improve recovery of the upper limb after stroke: rationale and description by means of the TIDieR checklist. Frontiers in neurology, 16, 1599762. https://doi.org/10.3389/fneur.2025.1599762 (https://pubmed.ncbi.nlm.nih.gov/41001199/). 9. Schick, T., Kolm, D., Leitner, A., Schober, S., Steinmetz, M., & Fheodoroff, K. (2022). Efficacy of Four-Channel Functional Electrical Stimulation on Moderate Arm Paresis in Subacute Stroke Patients-Results from a Randomized Controlled Trial. Healthcare (Basel, Switzerland), 10(4), 704. https://doi.org/10.3390/healthcare10040704 (https://pubmed.ncbi.nlm.nih.gov/35455881/). 10. Sukal, T. M., Ellis, M. D., & Dewald, J. P. (2007). Shoulder abduction-induced reductions in reaching work area following hemiparetic stroke: neuroscientific implications. Experimental brain research, 183(2), 215–223. https://doi.org/10.1007/s00221-007-1029-6 (https://pubmed.ncbi.nlm.nih.gov/17634933/) 11. Whitall, J., McCombe Waller, S., Silver, K. H., & Macko, R. F. (2000). Repetitive bilateral arm training with rhythmic auditory cueing improves motor function in chronic hemiparetic stroke. Stroke, 31(10), 2390–2395. https://doi.org/10.1161/01.str.31.10.2390 (https://pubmed.ncbi.nlm.nih.gov/11022069/).

One of the most common questions Dr. Kristina Spaulding hears is whether stress “stays in the system” for three days. In this episode, she digs into what that really means, what the research shows, and why the truth is more complex than a simple yes or no.She begins with the biology of the stress response—how the HPA axis and sympathetic nervous system work together, the roles of cortisol and corticosterone, and why not all stress is bad. Then she takes on the central question: how long does stress actually last? You'll learn how long it typically takes for stress hormones to peak and return to baseline, and the many factors that influence recovery, making exact estimates of the duration of the stress response extremely difficult.Dr. Spaulding also explores sensitization and cross-sensitization—how prior stress can make animals more reactive to future challenges, even entirely different ones. This has big implications for understanding anxiety, PTSD, and the impacts of stress on behavior. Finally, she discusses chronic and developmental stress and why a blunted stress response doesn't necessarily mean an animal is “fine.”The idea that stress lingers for three days is a myth. Hormones often normalize within hours, but the effects of stress—especially repeated or early-life stress—can last for days, weeks, or even a lifetime.Resources:Garcia, Arantxa, Octavi Marti, Astrid Valles, Silvina Dal-Zotto, and Antonio Armario. “Recovery of the Hypothalamic-Pituitary-Adrenal Response to Stress: Effect of Stress Intensity, Stress Duration and Prevention Stress Exposure.” Neuroendocrinology 72, no. 2 (August 2000): 114–25.Belda, X., Rotllant, D., Fuentes, S., Delgado, R., Nadal, R., & Armario, A. (2008). Exposure to severe stressors causes long‐lasting dysregulation of resting and stress‐induced activation of the hypothalamic‐pituitary‐adrenal axis. Annals of the New York Academy of Sciences, 1148(1), 165-173.For more information, please check out my website and social media links below! Website: https://sciencemattersllc.com/ Unlocking Resilience: https://sciencemattersllc.com/unlocking-resilience Research Bites: https://sciencemattersllc.com/research-bites Join the Science Matters newsletter Facebook ...

It's part 2 of our dive into the Insect Apocalypse, with our good friend Dr. Jason Dombroskie from the Cornell University Insect Collection!In this part, Jason fills us in on the drivers of the Insect Apocalypse and - most importantly - what we can do about it.This episode was recorded on August 21, 2025 at Rattlesnake Hill Wildlife Management Area in Dalton, NY.. Episode NotesDuring the episode, we made the claim that 40 million acres of the US is lawn, and that that area is equal to all of the country's National Parks put together. True? Well, sort of. The claim that the U.S. has about 40 million acres of lawn—roughly equal to all our national parks combined—is only partly true. A NASA-funded study led by Cristina Milesi estimated that turfgrass covers about 128,000 km² (≈31 million acres) of the continental U.S., making it the largest irrigated “crop” in the country (Milesi et al., Environmental Management, 2005; NASA Earth Observatory). Later analyses and popular summaries often round that up to ≈40 million acres (e.g., Scienceline, 2011; LawnStarter, 2023). By comparison, the total land area of all officially designated U.S. National Parks is about 52.4 million acres, while the entire National Park System—which also includes monuments, preserves, and historic sites—covers about 85 million acres (National Park Service, 2024). So while lawns and parks occupy areas of similar magnitude, lawns do not actually equal or exceed the combined area of the national parks. Is it better to mulch leaves on your lawn or leave them be? Here's what we found: It's generally best to mulch your leaves with a mower rather than rake or remove them. Research from Michigan State University found that mowing leaves into small pieces allows them to decompose quickly, returning nutrients to the soil and reducing weeds like dandelions and crabgrass (MSU Extension, “Don't rake leaves — mulch them into your lawn”, 2012). Cornell University studies similarly show that mulched leaves improve soil structure, moisture retention, and microbial activity (Cornell Cooperative Extension, “Leaf Mulching: A Sustainable Alternative”, 2019). However, in garden beds, wooded edges, or under shrubs, it's often better to leave leaves whole, since they provide winter habitat for butterflies, bees, and other invertebrates that overwinter in leaf litter (National Wildlife Federation, “Leave the Leaves for Wildlife”, 2020). The ideal approach is a mix: mow-mulch leaves on grassy areas for turf health and leave them intact where they naturally fall to support biodiversity and soil ecology. Episode LinksThe Cornell University Insect Collection Also, check out their great Instagram feedAnd their annual October event InsectapaloozaFind out more about the recently discovered species of Swallowtail, Papilio solstitius, commonly known as the Midsummer Tiger Swallowtail- https://www.sci.news/biology/papilio-solstitius-13710.htmlSponsors and Ways to Support UsThank you to Always Wandering Art (Website and Etsy Shop) for providing the artwork for many of our episodes.Support us on Patreon.Works CitedBiesmeijer, J.C., Roberts, S.P., Reemer, M., Ohlemuller, R., Edwards, M., Peeters, T., Schaffers, A.P., Potts, S.G., Kleukers, R.J.M.C., Thomas, C.D. and Settele, J., 2006. Parallel declines in pollinators and insect-pollinated plants in Britain and the Netherlands. Science, 313(5785), pp.351-354. Boyle, M.J., Bonebrake, T.C., Dias da Silva, K., Dongmo, M.A., Machado França, F., Gregory, N., Kitching, R.L., Ledger, M.J., Lewis, O.T., Sharp, A.C. and Stork, N.E., 2025. Causes and consequences of insect decline in tropical forests. Nature Reviews Biodiversity, pp.1-17. Burghardt, K.T., Tallamy, D.W., Philips, C. and Shropshire, K.J., 2010. Non‐native plants reduce abundance, richness, and host specialization in lepidopteran communities. Ecosphere, 1(5), pp.1-22. Colla, S.R. and Packer, L., 2008. Evidence for decline in eastern North American bumblebees (Hymenoptera: Apidae), with special focus on Bombus affinis Cresson. Biodiversity and Conservation, 17(6), pp.1379-1391. Crossley, M.S., Meier, A.R., Baldwin, E.M., Berry, L.L., Crenshaw, L.C., Hartman, G.L., Lagos-Kutz, D., Nichols, D.H., Patel, K., Varriano, S. and Snyder, W.E., 2020. No net insect abundance and diversity declines across US Long Term Ecological Research sites. Nature Ecology & Evolution, 4(10), pp.1368-1376. DeWalt, R.E., Favret, C. and Webb, D.W., 2005. Just how imperiled are aquatic insects? A case study of stoneflies (Plecoptera) in Illinois. Annals of the Entomological Society of America, 98(6), pp.941-950. Edwards, C.B., Zipkin, E.F., Henry, E.H., Haddad, N.M., Forister, M.L., Burls, K.J., Campbell, S.P., Crone, E.E., Diffendorfer, J., Douglas, M.R. and Drum, R.G., 2025. Rapid butterfly declines across the United States during the 21st century. Science, 387(6738), pp.1090-1094. Gaona, F.P., Iñiguez-Armijos, C., Brehm, G., Fiedler, K. and Espinosa, C.I., 2021. Drastic loss of insects (Lepidoptera: Geometridae) in urban landscapes in a tropical biodiversity hotspot. Journal of Insect Conservation, 25(3), pp.395-405. Gardiner, M.M., Allee, L.L., Brown, P.M., Losey, J.E., Roy, H.E. and Smyth, R.R., 2012. Lessons from lady beetles: accuracy of monitoring data from US and UK citizen‐science programs. Frontiers in Ecology and the Environment, 10(9), pp.471-476. Groenendijk, D. and van der Meulen, J., 2004. Conservation of moths in The Netherlands: population trends, distribution patterns and monitoring techniques of day-flying moths. Journal of Insect Conservation, 8(2), pp.109-118. Haddad, N.M., Haarstad, J. and Tilman, D., 2000. The effects of long-term nitrogen loading on grassland insect communities. Oecologia, 124(1), pp.73-84. Hallmann, C.A., Sorg, M., Jongejans, E., Siepel, H., Hofland, N., Schwan, H., Stenmans, W., Müller, A., Sumser, H., Hörren, T. and Goulson, D., 2017. More than 75 percent decline over 27 years in total flying insect biomass in protected areas. PLoS ONE12 (10): e0185809 Hallmann, C.A., Ssymank, A., Sorg, M., de Kroon, H. and Jongejans, E., 2021. Insect biomass decline scaled to species diversity: General patterns derived from a hoverfly community. Proceedings of the National Academy of Sciences, 118(2), p.e2002554117. Harris, J.E., Rodenhouse, N.L. and Holmes, R.T., 2019. Decline in beetle abundance and diversity in an intact temperate forest linked to climate warming. Biological Conservation, 240, p.108219. Hembry, D.H., 2013. Herbarium Specimens Reveal Putative Insect Extinction on the Deforested Island of Mangareva (Gambier Archipelago, French Polynesia). Pacific Science, 67(4), pp.553-560. Høye, T.T., Loboda, S., Koltz, A.M., Gillespie, M.A., Bowden, J.J. and Schmidt, N.M., 2021. Nonlinear trends in abundance and diversity and complex responses to climate change in Arctic arthropods. Proceedings of the National Academy of Sciences, 118(2), p.e2002557117. Huryn, A.D. and Wallace, J.B., 2000. Life history and production of stream insects. Annual review of entomology, 45(1), pp.83-110. Kawahara, A.Y., Reeves, L.E., Barber, J.R. and Black, S.H., 2021. Eight simple actions that individuals can take to save insects from global declines. Proceedings of the National Academy of Sciences, 118(2), p.e2002547117. Leuenberger, W., Doser, J.W., Belitz, M.W., Ries, L., Haddad, N.M., Thogmartin, W.E. and Zipkin, E.F., 2025. Three decades of declines restructure butterfly communities in the Midwestern United States. Proceedings of the National Academy of Sciences, 122(33), p.e2501340122. Liang, M., Yang, Q., Chase, J.M., Isbell, F., Loreau, M., Schmid, B., Seabloom, E.W., Tilman, D. and Wang, S., 2025. Unifying spatial scaling laws of biodiversity and ecosystem stability. Science, 387(6740), p.eadl2373. Lister, B.C. and Garcia, A., 2018. Climate-driven declines in arthropod abundance restructure a rainforest food web. Proceedings of the National Academy of Sciences, 115(44), pp.E10397-E10406. Owens, A.C., Pocock, M.J. and Seymoure, B.M., 2024. Current evidence in support of insect-friendly lighting practices. Current Opinion in Insect Science, 66, p.101276. Myers, L.W., Kondratieff, B.C., Grubbs, S.A., Pett, L.A., DeWalt, R.E., Mihuc, T.B. and Hart, L.V., 2025. Distributional and species richness patterns of the stoneflies (Insecta, Plecoptera) in New York State. Biodiversity Data Journal, 13, p.e158952. Pilotto, F., Kühn, I., Adrian, R., Alber, R., Alignier, A., Andrews, C., Bäck, J., Barbaro, L., Beaumont, D., Beenaerts, N. and Benham, S., 2020. Meta-analysis of multidecadal biodiversity trends in Europe. Nature communications, 11(1), p.3486. Pinkert, S., Farwig, N., Kawahara, A.Y. and Jetz, W., 2025. Global hotspots of butterfly diversity are threatened in a warming world. Nature Ecology & Evolution, pp.1-12. Raven, P.H. and Wagner, D.L., 2021. Agricultural intensification and climate change are rapidly decreasing insect biodiversity. Proceedings of the National Academy of Sciences, 118(2), p.e2002548117. Rodrigues, A.V., Rissanen, T., Jones, M.M., Huikkonen, I.M., Huitu, O., Korpimäki, E., Kuussaari, M., Lehikoinen, A., Lindén, A., Pietiäinen, H. and Pöyry, J., 2025. Cross‐Taxa Analysis of Long‐Term Data Reveals a Positive Biodiversity‐Stability Relationship With Taxon‐Specific Mechanistic Underpinning. Ecology Letters, 28(4), p.e70003. Salcido, D.M., Forister, M.L., Garcia Lopez, H. and Dyer, L.A., 2020. Loss of dominant caterpillar genera in a protected tropical forest. Scientific reports, 10(1), p.422. Sánchez-Bayo, F. and Wyckhuys, K.A., 2019. Worldwide decline of the entomofauna: A review of its drivers. Biological conservation, 232, pp.8-27. Schowalter, T.D., Pandey, M., Presley, S.J., Willig, M.R. and Zimmerman, J.K., 2021. Arthropods are not declining but are responsive to disturbance in the Luquillo Experimental Forest, Puerto Rico. Proceedings of the National Academy of Sciences, 118(2), p.e2002556117. Sedlmeier, J.E., Grass, I., Bendalam, P., Höglinger, B., Walker, F., Gerhard, D., Piepho, H.P., Brühl, C.A. and Petschenka, G., 2025. Neonicotinoid insecticides can pose a severe threat to grassland plant bug communities. Communications Earth & Environment, 6(1), p.162. Shortall, C.R., Moore, A., Smith, E., Hall, M.J., Woiwod, I.P. and Harrington, R., 2009. Long‐term changes in the abundance of flying insects. Insect Conservation and Diversity, 2(4), pp.251-260. Soga, M. and Gaston, K.J., 2018. Shifting baseline syndrome: causes, consequences, and implications. Frontiers in Ecology and the Environment, 16(4), pp.222-230. Stork, N.E., 2018. How many species of insects and other terrestrial arthropods are there on Earth?. Annual review of entomology, 63(2018), pp.31-45. Tallamy, D.W., Narango, D.L. and Mitchell, A.B., 2021. Do non‐native plants contribute to insect declines?. Ecological Entomology, 46(4), pp.729-742. Thomas, J.A., Telfer, M.G., Roy, D.B., Preston, C.D., Greenwood, J.J.D., Asher, J., Fox, R., Clarke, R.T. and Lawton, J.H., 2004. Comparative losses of British butterflies, birds, and plants and the global extinction crisis. Science, 303(5665), pp.1879-1881. Tierno de Figueroa, J.M., López-Rodríguez, M.J., Lorenz, A., Graf, W., Schmidt-Kloiber, A. and Hering, D., 2010. Vulnerable taxa of European Plecoptera (Insecta) in the context of climate change. Biodiversity and conservation, 19(5), pp.1269-1277. Turin, H. and Den Boer, P.J., 1988. Changes in the distribution of carabid beetles in The Netherlands since 1880. II. Isolation of habitats and long-term time trends in the occurence of carabid species with different powers of dispersal (Coleoptera, Carabidae). Biological Conservation, 44(3), pp.179-200. Van Deynze, B., Swinton, S.M., Hennessy, D.A., Haddad, N.M. and Ries, L., 2024. Insecticides, more than herbicides, land use, and climate, are associated with declines in butterfly species richness and abundance in the American Midwest. PLoS One, 19(6), p.e0304319. Van Klink, R., Bowler, D.E., Gongalsky, K.B., Swengel, A.B., Gentile, A. and Chase, J.M., 2020. Meta-analysis reveals declines in terrestrial but increases in freshwater insect abundances. Science, 368(6489), pp.417-420. Wagner, D.L., Fox, R., Salcido, D.M. and Dyer, L.A., 2021. A window to the world of global insect declines: Moth biodiversity trends are complex and heterogeneous. Proceedings of the National Academy of Sciences, 118(2), p.e2002549117. Wagner DL, Grames EM, Forister ML, Berenbaum MR, Stopak D. Insect decline in the Anthropocene: Death by a thousand cuts. Proceedings of the National Academy of Sciences. 2021 Jan 12;118(2):e2023989118. WallisDeVries, M.F. and van Swaay, C.A., 2017. A nitrogen index to track changes in butterfly species assemblages under nitrogen deposition. Biological Conservation, 212, pp.448-453. Warren, M.S., Hill, J.K., Thomas, J.A., Asher, J., Fox, R., Huntley, B., Roy, D.B., Telfer, M.G., Jeffcoate, S., Harding, P. and Jeffcoate, G., 2001. Rapid responses of British butterflies to opposing forces of climate and habitat change. Nature, 414(6859), pp.65-69. Warren, M.S., Maes, D., van Swaay, C.A., Goffart, P., Van Dyck, H., Bourn, N.A., Wynhoff, I., Hoare, D. and Ellis, S., 2021. The decline of butterflies in Europe: Problems, significance, and possible solutions. Proceedings of the National Academy of Sciences, 118(2), p.e2002551117. Wilson, E.O., 1987. The little things that run the world (the importance and conservation of invertebrates). Conservation biology, pp.344-346. Yang, L.H. and Gratton, C., 2014. Insects as drivers of ecosystem processes. Current opinion in insect science, 2, pp.26-32.Visit thefieldguidespodcast.com for full episode notes, links, and works cited.

On this episode of Dynamo Faithful, the lads recap the match vs San DIego, talk about the latest dynanews, preview the match vs SKC, then wrap up by picking where they might want to see Raines land in Europe.Be sure to follow us on Instagram and Twitter @Dynamo_Faithful and let us know what you think! We appreciate any feedback on how to improve the pod going forward, and please consider rating and reviewing us on your favorite podcast platform!Appearing on this episode are Chris Sinski, Krystopher Scroggins, and Manny Farciert.Produced & Edited by Ian Gregory-GraffSocial Media & Design by Zacj BellotMusic from Pixabay: Intro/Outro Song: Indie Folk (King Around Here) by Alex Grohl

Sara dives into one of the most unforgettable parts of drinking → hangovers. From her worst-ever hangover in Punta Cana to the subtle shame-filled Sundays that followed too many nights out, Sara breaks down how hangovers evolved throughout her drinking years and how they became one of the biggest motivators for her sobriety. She doesn't stop at personal stories. Sara also explores the science of hangovers: what's actually happening inside your body and brain when you're feeling miserable the next day. You'll learn why alcohol leads to dehydration, inflammation, anxiety, and that 3 a.m. wake-up, plus why “hair of the dog” only keeps the cycle going. If you've ever wondered why hangovers hit so hard or need a vivid reminder of what you're leaving behind, this episode is your reality check and your motivation to keep choosing a hangover-free life. 00:00 Introduction to the Podcast and Today's Topic 02:28 The Worst Hangover Experience 09:00 Evolution of Hangovers Over the Years 15:34 The Science Behind Hangovers 25:06 Conclusion

Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks.This month we're discussing:Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trialDOI: https://doi.org/10.1016/S0140-6736(25)01665-4Increasing the Potassium Level in Patients at High Risk for Ventricular ArrhythmiasDOI: ⁠https://doi.org/⁠10.1056/NEJMoa2509542Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled TrialDOI: https://doi.org/10.7326/ANNALS-25-00388Scientific team:Ricardo Ladeiras Lopes, Mário Santos and João Sérgio NevesDiscover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://linktr.ee/medicalportfolioapp⁠⁠

Author and researcher D. H. Morris reveals the gripping true story behind her historical novel The Girl of Many Crowns, following Princess Judith of Francia and Baldwin “Iron Arm.” We dig into how Deborah turned medieval annals, songs, and court records into a vivid, faith-infused saga of love, power, and defiance—plus the surprising family link that started it all. If you love stories where history breathes and the stakes are royal, this one's for you. Sponsored byDaniel McGhee & the Victory Team Guest Bio:  D. H. (Deborah) Morris is a playwright, world traveler, and historical-fiction author whose research spans medieval Latin sources and English scholarship. After tracing her own genealogy, she uncovered the real saga of Princess Judith of Francia and Baldwin Iron Arm, inspiring her debut novel The Girl of Many Crowns. A former theater professional and devoted researcher, Morris blends scholarly rigor with dramatic storytelling—and donates a portion of her book's proceeds to anti-trafficking efforts.  Main Topics: ·         How a genealogy puzzle led Deborah to Princess Judith & Baldwin Iron Arm. ·         Turning dense medieval sources into living scenes (annals, riddles, liturgy, songs). ·         Historical fiction vs. strict history: staying faithful while filling the gaps. ·         Judith's early marriages, agency, and defiance in a world of kings and councils. ·         Vikings, ransoms, and realpolitik: how raids, slavery, and silver shaped the plot. ·         Writing the audiobook herself—acting craft, character voice, and production. ·         Prequel in progress: Empress Judith, Charlemagne's court, and civil war stakes. ·         Why she donates proceeds to OUR/Operation Underground Railroad.  Resources mentioned: ·         The Girl of Many Crowns novel·         Princess Judith of Francia; Baldwin (Iron Arm); Alfred the Great; Charlemagne; Louis the Pious; Hincmar of Reims; Aachen. ·         Annals of St. Bertin Send us a textThe Victory TeamLOOKING TO BUY OR SELL A HOME Go with the Agent that was voted Harford's Best & won the Harford CouDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showRate & Review on Apple Podcasts Follow the Conversations with Rich Bennett podcast on Social Media:Facebook – Conversations with Rich Bennett Facebook Group (Join the conversation) – Conversations with Rich Bennett podcast group | FacebookTwitter – Conversations with Rich Bennett Instagram – @conversationswithrichbennettTikTok – CWRB (@conversationsrichbennett) | TikTok Sponsors, Affiliates, and ways we pay the bills:Hosted on BuzzsproutSquadCast Subscribe by Email

In this second part of our conversation with Professor Rylee Dionigi, we continue exploring the Masters sport phenomenon from a socio-cultural perspective. Ageing-as-decline discourse is nowadays challenged by active, healthy and successful ageing discourses. What are the opportunities but also potential problems associated with these competing discourses? What are the implications for exercise and health promotion with older adults? We also explore methodologies and methods that have been useful in Prof. Dionigi's research into Masters sport and physical activity. Rylee Dionigi is a professor in of Sport and Exercise Science at Charles Sturt University with expertise in qualitative research as well as sociology of active living and ageing. She has studied Masters sports for over 20 years and shared her insights from this extensive work in the podcast. Interested in exploring further? You can read more in Prof. Dionigi's works: Dionigi, R. A. (2015). Pathways to masters sport: Sharing stories from sport 'continuers','rekindlers' and 'late bloomers' In Physical activity and sport in later life (pp. 54-68). Palgrave Macmillan, London.   Dionigi, R. A. (2016). The Competitive Older Athlete. Topics in Geriatric Rehabilitation, 32(1), 55-62.   Dionigi, R. A. (2017). I would rather die than live sedentary. Topics in Geriatric Rehabilitation, 33(3), 156-161.   Dionigi, R. A. (2021). From fascination to revelation: my research journey with older MastersVeteran athletes. In Research Handbook on Sports and Society (pp. 244-259). Edward Elgar Publishing.   Dionigi, R. A., & Gard, M. (2018). Sport and Physical Activity across the Lifespan Critical Perspectives. Springer.   Gard, M., Dionigi, R. A., Horton, S., Baker, J., Weir, P., & Dionigi, C. (2017). The normalization of sport for older people?. Annals of leisure research, 20(3), 253-272.

Opportunities for involvement in sports in later life have increased significantly and many sports around the globe have competitions and categories for Masters/Veteran athletes. At the same time, researchers have explored the experiences and meanings of being an older athlete, showing tensions in individual experiences as well as in shifting social discourse surrounding sport and ageing. We have shifted from ageing-as-decline to active ageing discourses, which provide different imagination of growing old. But are there also some darker sides in the shift towards more positive visions of ageing? Rylee Dionigi is a professor in of Sport and Exercise Science at Charles Sturt University with expertise in qualitative research as well as sociology of active living and ageing. She has studied Masters sports for over 20 years and shared her insights from this extensive work in the podcast. Questions explored in the conversation include: How did the cultural discourses shift in the last 20 years? Have athletes' experiences and meanings of sport also shifted at the same time? What are the different pathways to Masters sport and do they map into different relationships with sport? Why are active ageing discourses also potentially problematic? Interested? You can read more in Prof. Dionigi's works: Dionigi, R. A. (2015). Pathways to masters sport: Sharing stories from sport 'continuers','rekindlers' and 'late bloomers' In Physical activity and sport in later life (pp. 54-68). Palgrave Macmillan, London.   Dionigi, R. A. (2016). The Competitive Older Athlete. Topics in Geriatric Rehabilitation, 32(1), 55-62.   Dionigi, R. A. (2017). I would rather die than live sedentary. Topics in Geriatric Rehabilitation, 33(3), 156-161.   Dionigi, R. A. (2021). From fascination to revelation: my research journey with older MastersVeteran athletes. In Research Handbook on Sports and Society (pp. 244-259). Edward Elgar Publishing.   Dionigi, R. A., & Gard, M. (2018). Sport and Physical Activity across the Lifespan Critical Perspectives. Springer.   Gard, M., Dionigi, R. A., Horton, S., Baker, J., Weir, P., & Dionigi, C. (2017). The normalization of sport for older people?. Annals of leisure research, 20(3), 253-272.

You don't need to “fix” your metabolism—because it's probably not broken.In this episode, I'm cutting through all the BS around metabolism, especially the myths that have kept women stuck, frustrated, and blaming their hormones, their carbs, or their age. Based on game-changing science (yes, real science), you'll learn what actually influences your metabolism—and how to take back control of your energy, body composition, and long-term health.Spoiler: it's not about eating less, working out more, or chasing hacks. It's about supporting your fat tissue so it supports you.Here's what we cover:The groundbreaking study that reshaped everything we thought about metabolismWhy your metabolism likely hasn't slowed down (even in your 40s or 50s)What fat tissue has to do with energy, cravings, and inflammationThe real impact of carbs, hormones, and “starvation mode”5 foundational shifts that actually improve metabolic healthYour metabolism isn't the villain. And you're not broken. You just need to stop fighting your body—and start working with it.Get Weekly Health Tips:  thrivehealthcoachllc.comLet's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.comPodcast Produced by Virtually You! Sources:Hall, K. D., Kahan, S., & Gallagher, I. H. (2016). Energy balance and its components: Implications for body weight regulation. The American Journal of Clinical Nutrition, 104(4), 989–1003. https://doi.org/10.3945/ajcn.116.133280Koliaki, C., & Roden, M. (2016). Alterations of mitochondrial function and insulin sensitivity in human obesity and diabetes mellitus. Annual Review of Nutrition, 36, 337–367. Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes MellitusPontzer, H., Yamada, Y., Sagayama, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., … & Speakman, J. R. (2021). Daily energy expenditure through the human life course. Science, 373(6556), 808–812. Daily energy expenditure through the human life courseSpiegel, K., Tasali, E., Penev, P., & Van Cauter, E. (2004). Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Annals of Internal Medicine, 141(11), 846–850. Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite | Annals of Internal Medicine

Dr Jess Stokes Parish (science communicator and ICU nurse) joins Preeya to tackle the beast of health misinformation. Why was Belle Gibson so effective at spreading false information? Was Belle unique or is the issue far more widespread? How do you spot dodgy health content online when there's so much of it and even qualified health professionals get confused at times? This episode includes practical tips to navigate this space (for both community members and health professionals). If you want to check out more about the CRABS framework referred to in the episode check out: https://www.jessicastokesparish.com/blog/crabs-the-credibility-frameworkAnti-Vaccine Cartoonhttps://museumandarchives.redcross.org.uk/objects/46927History of Vaccineshttps://historyofvaccines.org/vaccines-101/misconceptions-about-vaccines/history-anti-vaccination-movementsTaylor et al (2014). Vaccines are not associated with autism: an evidence-based meta-analysis of case-control and cohort studies. Vaccine.Hviid et al 2019. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Annals of Internal Medicine.SKAI. 2025. What about autism?  https://skai.org.au/childhood/questions/what-about-autismPugh et al 2022. The unnaturalistic fallacy: COVID-19 vaccine mandates should not discriminate against natural immunity. BMJ Journal of Medical Ethics.CHOP. 2021. Immune System and Vaccines. https://www.chop.edu/vaccine-education-center/human-immune-system/immune-system-and-vaccineshttps://www.aihw.gov.au/reports/australias-health/what-are-determinants-of-healthHealth literacy, social media and misinformationhttps://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-022-13599-7Zang et al 2023. What Do We Mean When We Talk about Trust in Social Media? A Systematic Review. rXiv:2302.03671v1Lewandowsky et al (2012). Misinformation and its correction: continued influence and successful debiasing. DOI: 10.1177/1529100612451018Lewandowsky et al (2020). The Debunking Handbook 2020. DOI:10.17910/b7.1182Al Khaja, K.A.J., AlKhaja, A.K. & Sequeira, R.P. Drug information, misinformation, and disinformation on social media: a content analysis study. J Public Health Pol 39, 343–357 (2018). https://doi.org/10.1057/s41271-018-0131-2Denniss, E., Lindberg, R., Marchese, L.E. et al. #Fail: the quality and accuracy of nutrition-related information by influential Australian Instagram accounts. Int J Behav Nutr Phys Act 21, 16 (2024). https://doi.org/10.1186/s12966-024-01565-yMueller SM, Jungo P, Cajacob L, Schwegler S, Itin P, Brandt OThe Absence of Evidence is Evidence of Non-Sense: Cross-Sectional Study on the Quality of Psoriasis-Related Videos on YouTube and Their Reception by Health SeekersJ Med Internet Res 2019;21(1):e11935Chung et al (2012). Safe infant sleep recommendations on the internet: let's google it.  DOI:https://doi.org/10.1016/j.jpeds.2012.06.004Daraz et al (2019). Can patients trust online health information? a meta-narrative systematic review addressing the quality of health information on the internet. DOI: 10.1007/s116606-019-05109-0Stokes-Parish J. Navigating the Credibility of Web-Based Information During the COVID-19 Pandemic: Using Mnemonics to Empower the Public to Spot Red Flags in Health Information on the Internet. J Med Internet Res 2022;24(6):e38269doi: 10.2196/38269 Sunscreen MisinformationCathal O'Connor, Siobhán Rafferty, Michelle Murphy, A qualitative review of misinformation and conspiracy theories in skin cancer, Clinical and Experimental Dermatology, Volume 47, Issue 10, 1 October 2022, Pages 1848–1852, https://doi.org/10.1111/ced.15249Instagram: ⁠⁠⁠⁠@doctor.preeya.alexander⁠⁠⁠⁠Books: ⁠⁠⁠⁠Eat, Sleep, Play, Love⁠⁠⁠ by Dr Preeya Alexander⁠⁠⁠⁠Full Plate⁠⁠⁠⁠, out nowTo find out more about AIA Australia head to ⁠⁠www.aia.com.au⁠

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Ryan Courtney from the University of New South Wales, Australia. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Ryan Courtney from the National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia In the September podcast Ryan Courtney talks about his recent randomised controlled trial looking at vaporised nicotine products (VNP, e-cigarettes) compared to nicotine replacement therapy (gum/ lozenges) for smoking cessation among people experiencing social disadvantage. This study was funded by Australian National Health and Medical Research Council and included 1045 people at the start of the study with 866 people completing follow up. The verified 6-month continuous abstinence rate was 28.4% (148 of 522) in the e-cigarette group and 9.6% (50 of 523) in the NRT group. Their findings indicate that e-cigarettes are more effective than NRT for smoking cessation in this population. Given the challenges for cessation among these socially disadvantaged populations, the authors of the study consider that e-cigarettes present a promising treatment option for this priority group. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our searches for the EC for smoking cessation review carried out on 1st August and 1st September 2025 found four new studies (10.7326/ANNALS-24-03531 by Courtney et al discussed in this podcast; 10.1016/S2468-2667(25)00101-X; 10.1186/s12916-025-04167-y; 10.1016/j.ypmed.2025.108389). The searches found six papers linked studies included in the review (10.57187/s.4571; 10.1186/s13063-025-08954-z; 10.1111/add.70115; 10.1016/j.ypmed.2025.108353; 10.1016/j.drugalcdep.2025.112821; 10.3310/JHFR0841). Our search for our interventions for quitting vaping review carried out 1st August and 1st September 2025 found two new ongoing studies (NCT07040566; ISRCTN11383698), and one linked paper (10.1016/S2468-2667(25)00145-8). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Send us a Text Message (please include your email so we can respond!)Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM.SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/SBT Timing (Annals ATS): https://www.atsjournals.org/doi/10.1513/AnnalsATS.202502-188OCIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a message with this link, we would love to hear from you. Standard message rates may apply.Colon cancer screening saves lives by catching cancer early and even preventing it, yet only 69% of eligible adults are up to date with their screenings. We explore who needs screening, what tests are available, and how to choose the right one for you.• Most adults should start colon cancer screening at age 45, even if healthy• Family history may mean you need to start screening earlier• Stool-based tests like FIT and Cologuard are convenient home options• Colonoscopy remains the gold standard, allowing doctors to remove polyps• One in 23 men and one in 25 women will develop colorectal cancer• The best screening test is the one you'll actually completePlease get screened! Check with your doctor about which test is right for you based on your risk factors and preferences.References1. Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement From the American College of Physicians (Version 2). Qaseem A, Harrod CS, Crandall CJ, et al. Annals of Internal Medicine. 2023;176(8):1092-1100. doi:10.7326/M23-0779.2. AGA Clinical Practice Update on Risk Stratification for Colorectal Cancer Screening and Post-Polypectomy Surveillance: Expert Review. Issaka RB, Chan AT, Gupta S. Gastroenterology. 2023;165(5):1280-1291. doi:10.1053/j.gastro.2023.06.033.3. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. Davidson KW, Barry MJ, Mangione CM, et al. JAMA. 2021;325(19):1965-1977. doi:10.1001/jama.2021.6238.4. Colorectal Cancer Screening and Prevention. Sur DKC, Brown PC. American Family Physician. 2025;112(3):278-283.5. Increasing Incidence of Early-Onset Colorectal Cancer. Sinicrope FA. The New England Journal of Medicine. 2022;386(16):1547-1558. doi:10.1056/NEJMra2200869.6. From Guideline to Practice: New Shared Decision-Making Tools for Colorectal Cancer Screening From the American Cancer Society. Volk RJ, Leal VB, Jacobs LE, et al. CA: A Cancer Journal for Clinicians. 2018;68(4):246-249. doi:10.3322/caac.21459.7. Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. Lin JS, Perdue LA, Henrikson NB, Bean SI, Blasi PR. JAMA. 2021;325(19):1978-1998. doi:10.1001/jama.2021.4417.8. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. Bibbins-Domingo K, Grossman DC, Curry SJ, et al. JAMA. 2016;315(23):2564-2575. doi:10.1001/jama.2016.5989.9. How Would You Screen This Patient for Colorectal Cancer? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Burns RB, Mangione CM, Weinberg DS, Kanjee Z. Annals of Internal Medicine. 2022;175(10):1452-1461. doi:10.7326/M22-1961.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

We live in a culture obsessed with treating symptoms, weight gain, fatigue, high blood pressure, brain fog, poor sleep, as if each were an isolated problem. But what if these struggles aren't the problem at all? What if they're just the flashing check engine lights on the dashboard of your body, pointing to a deeper issue that's been hiding in plain sight: Metabolic Disease. In this episode, Dr. JC Doornick pulls back the curtain on why nearly every chronic health crisis in America today — from obesity and Type 2 diabetes to heart disease, hypertension, and even dementia — can be traced back to metabolic dysfunction. He explains how the healthcare industry profits from keeping us stuck in a never-ending cycle of pills, injections, and quick fixes, rather than empowering us to address the root cause upstream. You'll also learn about Metabolic Synchronization — a practical, upstream approach that helps realign the body and mind through five key foundations: Proper diet & nutrition Proper movement & muscle development Proper sleep Proper education & mental detox Proper community & support This episode is a wake-up call: the lights are flashing, and the choice is yours. Will you keep patching symptoms downstream, or will you finally pop the hood and reclaim control of your health, your mind, and your future?

Why are we still treating acute uncomplicated diverticulitis with antibiotics? There is plenty of evidence from several randomized controlled trials demonstrating that symptomatic management alone yields similar results. If we should continue prescribing antibiotics for acute uncomplicated diverticulitis, which patients should undergo treatment and when? Join Drs. Jared Hendren, Elissa Dabaghi, Joseph Trunzo, Ajaratu Keshinro, and David Rosen as they discuss the management of uncomplicated diverticulitis while reviewing groundbreaking literature. Hosts: -Jared Hendren, MD Institution: Department of General Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio - Elissa Dabaghi, MD Institution: Department of General Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio - Joseph Trunzo, MD Institution: Department of Colon and Rectal Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio Social Media Handle: X/Twitter @joseph_trunzo - Ajaratu Keshinro, MD Institution: Department of Colon and Rectal Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio Social Media Handle: X/Twitter- @AJKesh - David Rosen, MD Institution: Department of Colon and Rectal Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio Social Media Handle: X/Twitter- @davidrrosenmd Learning Objectives: By the end of this episode, listeners will be able to: 1.     Identify criteria for managing acute uncomplicated diverticulitis without antibiotics based on recent literature 2.     Define uncomplicated and complicated diverticulitis 3.     Discuss nuanced management decisions of patients with uncomplicated diverticulitis to determine when antibiotics may be appropriate for management References: 1.     Azhar, N., Aref, H., Brorsson, A., Lydrup, M.‑L., Jörgren, F., Schultz, J. K., & Buchwald, P. (2022). Management of acute uncomplicated diverticulitis without antibiotics: Compliance and outcomes – a retrospective cohort study. BMC Emergency Medicine, 22(1), Article 28. https://doi.org/10.1186/s12873‑022‑00584‑X  2.     Mora‑López, L., Ruiz‑Edo, N., Estrada‑Ferrer, O., Piñana‑Campón, M. L., Labró‑Ciurans, M., Escuder‑Perez, J., Sales‑Mallafré, R., Rebasa‑Cladera, P., Navarro‑Soto, S., Serra‑Aracil, X., & DINAMO‑study Group. (2021). Efficacy and safety of nonantibiotic outpatient treatment in mild acute diverticulitis (DINAMO‑study): A multicentre, randomised, open‑label, noninferiority trial. Annals of Surgery, 274(5), e435–e442. https://doi.org/10.1097/SLA.0000000000005031 3.     Daniels, L., Ünlü, Ç., de Korte, N., van Dieren, S., Stockmann, H. B., Vrouenraets, B. C., Consten, E. C., van der Hoeven, J. A., Eijsbouts, Q. A., Faneyte, I. F., Bemelman, W. A., Dijkgraaf, M. G., & Boermeester, M. A. (2017). Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT‑proven uncomplicated acute diverticulitis. British Journal of Surgery, 104(1), 52‑61. https://doi.org/10.1002/bjs.10309 4.     Chabok, A., Påhlman, L., Hjern, F., Haapaniemi, S., & Smedh, K.; AVOD Study Group. (2012). Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. British Journal of Surgery, 99(4), 532–539. https://doi.org/10.1002/bjs.8688 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

Dr. Centor revisits information included in the Annals of Internal Medicine supplement "What You May Have Missed in 2024."

Indolent Systemic Mastocytosis (ISM) is a rare but often underrecognized clonal mast cell disorder. From random hives to gut pain and brain fog, ISM can feel like a medical mystery. We continue our review of “Management of indolent mastocytosis and mast cell activation syndrome - A clinical yardstick,” published in June 2025 in The Annals of Allergy, Asthma & Immunology. This is Part 2 of our discussion, with a focus on indolent systemic mastocytosis. We look at what causes it, how it's diagnosed, and how to manage symptoms and improve quality of life. In this episode, we break down this complex mast cell disease and how doctors use baseline serum tryptase, KIT D816V testing, and HaT screening to find answers. Plus, we explain how treatments like antihistamines, mast cell stabilizers, and avapritinib can help people live better with ISM.

In this episode Hecate discusses why menstruation can be triggering for survivors, especially for those who have been assaulted during their periods. Hecate provides statistics from medical studies indicating that a significant percentage of SA survivors were menstruating at the time of their assault. The combined social stigmas against speaking about SA and menstruation mean this is an experience that is not being talked about enough, leading to even greater feelings of isolation and shame. The episode also addresses some of the challenges of managing periods post-trauma, and different menstrual products through a survivor's lens. With personal anecdotes and research-backed insights, this episode aims to provide a voice to the often unspoken and overlooked intersection of menstruation and SA trauma. Hecate hopes this episode will help other survivors who have had this experience feel less alone.Tw/Cw: SA (and some details of assaults), R*pe, PTSD, menstruation, substances, and strong language.Links and References:Cardenas, K., Wiersma, G., Dykema, J., Rossman, L., Fedewa, J., & Jones, J. S. (2011). 279 impact of the victim's menstrual cycle phase on genital injuries following sexual assault. Annals of Emergency Medicine, 58(4). https://doi.org/10.1016/j.annemergmed.2011.06.309 Gollapudi, M., Thomas, A., Yogarajah, A., Ospina, D., Daher, J. C., Rahman, A., Santistevan, L., Patel, R. V., Abraham, J., Oommen, S. G., & Siddiqui, H. F. (2024). Understanding the interplay between premenstrual dysphoric disorder (PMDD) and female sexual dysfunction (FSD). Cureus, 16(6). https://doi.org/10.7759/cureus.62788 Noll, J. G., Trickett, P. K., Long, J. D., Negriff, S., Susman, E. J., Shalev, I., Li, J. C., & Putnam, F. W. (2017). Childhood sexual abuse and early timing of puberty. Journal of Adolescent Health, 60(1), 65–71. https://doi.org/10.1016/j.jadohealth.2016.09.008 Vu, A., Moaddel, V., Emmerich, B., Rossman, L., Bach, J., Seamon, J., Barnes, M., Ouellette, L., & Jones, J. (2023). Association between the victim's menstrual cycle phase and genital injuries following sexual assault. Clinical Journal of Obstetrics and Gynecology, 6(2), 038–042. https://doi.org/10.29328/journal.cjog.1001127 *Thank you again to my sister Chie for their invaluable help with research and citations!*Articles about the heavy metals found in tampons: https://factor.niehs.nih.gov/2024/8/feature/3-feature-metals-in-tamponshttps://publichealth.berkeley.edu/articles/spotlight/research/first-study-to-measure-toxic-metals-in-tampons-shows-arsenic-and-leadhttps://www.sciencedirect.com/science/article/pii/S0160412024004355#:~:text=Across%20those%20studies%2C%20a%20range,et%20al.%2C%202022).Lucky Iron Fish: https://luckyironlife.com/?srsltid=AfmBOorbSgfTM6sE3c6r-IRy3MNC0u-i8v-S4-s5lkZPo89aSCXJvEfjFinding OK: https://www.finding-ok.com/Hecate's Links: https://linktr.ee/FindingOK Support the Podcast and become a Patreon member!https://www.patreon.com/c/HecateFindingOKFinding OK is funded entirely by generosity of listeners like you!https://www.finding-ok.com/support/Music is "Your Heart is a Muscle the Size of Your Fist" used with the personal permission of Ramshackle Glory. Go check out their music!https://open.spotify.com/artist/0qdbl...Timestamps:00:00 Introduction and Trigger Warnings01:17 Menstruation and Trauma07:47 Challenges with Sanitary Products12:14 Personal Experiences of Assault During Menstruation15:58 Statistics and Research on Assault During Menstruation21:01 Triggers and Coping Mechanisms32:08 Conclusion and Support3Support the show

In the August issue of the Annals of Emergency Medicine podcast, Ryan and Rory discuss point-of-care high sensitivity troponins, intubation practices in community emergency medicine and much more.

All over the world, for all of human history – and probably going back to our earliest hominid ancestors – people have found ways to try to keep themselves clean. But how did soap come about? Research: “Soap, N. (1), Etymology.” Oxford English Dictionary, Oxford UP, June 2025, https://doi.org/10.1093/OED/1115187665. American Cleaning Institute. “Soaps & Detergents History.” https://www.cleaninginstitute.org/understanding-products/why-clean/soaps-detergents-history Beckmann, John. “History of Inventions, Discoveries and Origins.” William Johnston, translator. Bosart, L.W. “The Early History of the Soap Industry.” The American Oil Chemists' Society. Journal of Oil & Fat Industries 1924-10: Vol 1 Iss 2. Cassidy, Cody. “Who Discovered Soap? What to Know About the Origins of the Life-Saving Substance.” Time. 5/5/2020. https://time.com/5831828/soap-origins/ Ciftyurek, Muge, and Kasim Ince. "Selahattin Okten Soap Factory in Antakya and an Evaluation on Soap Factory Plan Typology/Antakya'da Bulunan Selahattin Okten Sabunhanesi ve Sabunhane Plan Tipolojisi Uzerine Bir Degerlendirme." Art-Sanat, no. 19, Jan. 2023, pp. 133+. Gale Academic OneFile, dx.doi.org/10.26650/artsanat.2023.19.1106544. Accessed 18 Aug. 2025. Costa, Albert B. “Michel-Eugène Chevreul.” Encyclopedia Britannica. https://www.britannica.com/biography/Michel-Eugene-Chevreul Curtis, Valerie A. “Dirt, disgust and disease: a natural history of hygiene.” Journal of epidemiology and community health vol. 61,8 (2007): 660-4. doi:10.1136/jech.2007.062380 Dijkstra, Albert J. “How Chevreul (1786-1889) based his conclusions on his analytical results.” OCL. Vol. 16, No. 1. January-February 2009. Gibbs, F.W. “The History and Manufacture of Soap.” Annals of Science. 1939. Koeppel, Dan. “The History of Soap.” 4/15/2020. https://www.nytimes.com/wirecutter/blog/history-of-soap/ List, Gary, and Michael Jackson. “Giants of the Past: The Battle Over Hydrogenation (1903-1920).” https://www.ars.usda.gov/research/publications/publication/?seqNo115=210614 Maniatis, George C. “Guild Organized Soap Manufacturing Industry in Constantinople: Tenth-Twelfth Centuries.” Byzantion, 2010, Vol. 80 (2010). https://www.jstor.org/stable/44173107 National Museum of American History. “Bathing (Body Soaps and Cleansers).” https://americanhistory.si.edu/collections/object-groups/health-hygiene-and-beauty/bathing-body-soaps-and-cleansers New Mexico Historic Sites. “Making Soap from the Leaves of the Soaptree Yucca.” https://nmhistoricsites.org/assets/files/selden/Virtual%20Classroom_Soaptree%20Yucca%20Soap%20Making.pdf “The history of soapmaking.” 8/30/2019. https://www.open.edu/openlearn/history-the-arts/history/history-science-technology-and-medicine/history-science/the-history-soapmaking Pliny the Elder. “The Natural History of Pliny. Translated, With Copious Notes and Illustrations.” Vol. 5. John Bostock, translator. https://www.gutenberg.org/files/60688/60688-h/60688-h.htm Pointer, Sally. “An Experimental Exploration of the Earliest Soapmaking.” EXARC Journal. 2024/3. 8/22/2024. https://exarc.net/issue-2024-3/at/experimental-exploration-earliest-soapmaking Ridner, Judith. “The dirty history of soap.” The Conversation. 5/12/2020. https://theconversation.com/the-dirty-history-of-soap-136434 Routh, Hirak Behari et al. “Soaps: From the Phoenicians to the 20th Century - A Historical Review.” Clinics in Dermatology. Vol. No. 3. 1996. Smith, Cyril Stanley, and John G. Hawthorne. “Mappae Clavicula: A Little Key to the World of Medieval Techniques.” Transactions of the American Philosophical Society, vol. 64, no. 4, 1974, pp. 1–128. JSTOR, https://doi.org/10.2307/1006317. Accessed 18 Aug. 2025. Timilsena, Yakindra Prasad et al. “Perspectives on Saponins: Food Functionality and Applications.” International journal of molecular sciences vol. 24,17 13538. 31 Aug. 2023, doi:10.3390/ijms241713538 “Craftsmanship of Aleppo Ghar soap.” https://ich.unesco.org/en/RL/craftsmanship-of-aleppo-ghar-soap-02132 “Tradition of Nabulsi soap making in Palestine.” https://ich.unesco.org/en/RL/tradition-of-nabulsi-soap-making-in-palestine-02112 “Soaps.” https://www.fs.usda.gov/wildflowers/ethnobotany/soaps.shtml van Dijk, Kees. “Soap is the onset of civilization.” From Cleanliness and Culture. Kees van Dijk and Jean Gelman Taylor, eds. Brill. 2011. https://www.jstor.org/stable/10.1163/j.ctvbnm4n9.4 Wei, Huang. “The Sordid, Sudsy Rise of Soap in China.” Sixth Tone. 8/11/2020. https://www.sixthtone.com/news/1006041 See omnystudio.com/listener for privacy information.

Send us a message with this link, we would love to hear from you. Standard message rates may apply.The flu vaccine is our best defense against influenza, a contagious respiratory virus that causes millions of illnesses and thousands of deaths in the US each year. Despite being only 40-60% effective, the vaccine significantly reduces hospitalizations, outpatient visits, and deaths while protecting vulnerable populations who cannot be vaccinated.• Influenza causes 9-41 million illnesses, 140,000-960,000 hospitalizations, and 12,000-80,000 deaths annually in the US• Everyone aged six months and older should receive the flu vaccine yearly• The vaccine must be updated annually because the flu virus changes each year• Getting vaccinated helps protect vulnerable populations like infants and immunocompromised individuals• Common misconception that the vaccine causes flu is false – it cannot give you the flu• Only 40-46% of Americans get the flu vaccine annually despite its proven benefits• The best time to get vaccinated is before flu season begins, but getting it later still helps• Flu vaccination reduces strain on hospitals during peak seasonsGo get your flu shot today! It's the best way to protect yourself, your loved ones, and your neighbors ReferencesPrevention and Control of Seasonal Influenza With Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022-23 Influenza Season. Grohskopf LA, Blanton LH, Ferdinands JM, et al. MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports. 2022;71(1):1-28. doi:10.15585/mmwr.rr7101a1. Copyright License: CC0.Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa. Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 2019;68(6):e1-e47. doi:10.1093/cid/ciy866.Influenza Vaccination. Treanor JJ. The New England Journal of Medicine. 2016;375(13):1261-8. doi:10.1056/NEJMcp1512870.Effects of Influenza Vaccination in the United States During the 2017-2018 Influenza Season. Rolfes MA, Flannery B, Chung JR, et al. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 2019;69(11):1845-1853. doi:10.1093/cid/ciz075.Vaccines for Preventing Influenza in Healthy Adults. Demicheli V, Jefferson T, Ferroni E, Rivetti A, Di Pietrantonj C. The Cochrane Database of Systematic Reviews. 2018;2:CD001269. doi:10.1002/14651858.CD001269.pub6.Recommendations for Prevention and Control of Influenza in Children, 2022-2023. Pediatrics. 2022;150(4):e2022059275. doi:10.1542/peds.2022-059275.Influenza. Uyeki TM. Annals of Internal Medicine. 2021;174(11):ITC161-ITC176. doi:10.7326/AITC202111160.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

In the second episode of this new collaboration between BTK and Annals of surgery, we discuss another hot topic: academic surgery. Specifically, we discuss dedicated research time for residents and how surgical leaders think about building the academic surgery enterprise. This discussion was inspired by a couple of recent papers in Annals of Surgery that stirred up a lot of conversation on social media which can be found below.  Host: Cody Mullens, MD MPH — general surgery resident at University of Michigan current BTK Surgery Education Fellow (@Cody_Mullens) Guest: Justin Dimick, MD MPH — Fredrick A Coller Distinguished Professor and Chair of Surgery at the University of you Michigan and Editor in Chief at Annals of Surgery (@jdimick1) Papers:  Career Trajectory After General Surgery Residency Do Academic Program Graduates Pursue Academic Surgery? https://journals.lww.com/annalsofsurgery/abstract/2025/05000/career_trajectory_after_general_surgery_residency_.10.aspx Training the Surgeon-scientist: Time (and Money) Well Spent? https://journals.lww.com/annalsofsurgery/citation/9900/training_the_surgeon_scientist__time__and_money_.1318.aspx Introducing a New Annals of Surgery Section Professional Development for the Contemporary Surgeon https://journals.lww.com/annalsofsurgery/fulltext/2025/08000/introducing_a_new_annals_of_surgery_section_.8.aspx Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen BTK Fan Favorites:  General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

This week we're traveling back to the 1960s with Nickel Boys! Join us as we learn about the horrific excavations of the Dozier School, the circulation of MLK speeches, Mexican-American identity in the South, and more! Sources: David Canfield Interview with RaMell Ross and Aunjanue Ellis-Taylor, Vanity Fair: https://www.vanityfair.com/hollywood/story/nickel-boys-telluride-exclusive-awards-insider?srsltid=AfmBOor0GmWj9WdElwUsFDSFjin9iJFcXiJGYeKF1ZkLFVGHvogkPHAI How Nickel Boys Was Filmed in First-Person POV: https://www.theverge.com/24318489/nickel-boys-ramell-ross-interview-first-person-cinematography Wikipedia: https://en.wikipedia.org/wiki/Nickel_Boys https://voicesofdemocracy.umd.edu/dr-martin-luther-king-jr-long-not-long-speech-text/ 1968 records, https://www.ebay.com/itm/256940070706?itmmeta=01K2N47HV7MRK73AZVCR13RX76&hash=item3bd2d25732:g:8r0AAOSwBGtoLQ7T&itmprp=enc%3AAQAKAAAA4MHg7L1Zz0LA5DYYmRTS30mP1%2Bszy%2Bf6oVsASGa76%2BT6T7uHacf7Cm%2FjdA%2ByTSvnvFH9qx4MXJebysIfG0bnMzw%2Frg1%2Fj2ZpEvbyaNVVJL8v8uA6ZDH637qT9DBURWwR5AP6X2UyjS84oaicywqrtGRJFmTDHiPdM3AOcdz6K1n9Sg9tqBwFtSjNZN087eDcc2UAPoK1nDJR1pEwKU43A5kTdTzxyUhfWrR84X1Wvn%2F5wP%2Fy%2FZvE88xfgNhiiK%2BHFWS9IiOayG2pBLCwn7ToT1GMXB8COAbYKcPx4%2B%2FF7pie%7Ctkp%3ABk9SR-SfnqSVZg,  https://www.ebay.com/itm/387262357112?itmmeta=01K2N47HV6C6JWENTA1FTVXKMD&hash=item5a2aa29e78:g:n2oAAOSwhKNmrrU-&itmprp=enc%3AAQAKAAAA4MHg7L1Zz0LA5DYYmRTS30m7rHgwCXW5OKCOZBpIuqTDUa8e4Fr6cjGgrnFXY1aiv3R98Ks0x7IkOcBlGJLQthx%2F6C9%2FiHxMFXf5Eu6o0Zyx73WrPpLQ23k2CC1sXLZLjxlzxqNofeY77UCrEUpDt07MjmRwneQ7hfCYySVT%2FHnEqbYH80QduZE01AADrpxFU19AXRUVL4OZpq7uKVG5%2F75WwJbYkvQpU04GmdY1wQgNuF3vEB7kdkDm5o4CeHpXtCZI%2FUMg1Jv1cpG6MKAoWypcYkmc9TmbkVgDdQEHvd6T%7Ctkp%3ABk9SR-KfnqSVZg Jarrod Hanson and Ruben Donato, "The Braceros: Mexican Workers in the Jim Crow South, 1949-1951," Social Education 83, no.1 (2019): 51-57.  Julie M. Weise, "Mexican Nationalisms, Southern Racisms: Mexicans and Mexican Americans in the U.S. South, 1908-1939," American Quarterly 60, no.3 (2008): 749-77.  Tyina Steptoe, ""Blaxicans" and Black Creoles," in Houston Bound: Culture and Color in a Jim Crow City (University of California Press, 2016). https://www.jstor.org/stable/10.1525/j.ctt19633hq.10   Erin Kimmerle et al, Report, Documentation of the Boot Hill Cemetery (8JA1860) at the Former Arthur G. Dozier School for Boys: Interim Report, 2012  https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=1000&context=dozier_school  Erin Kimmerle, "Forensic Anthropology in Long-Term Investigations: 100 Cold Years," Annals of Anthropological Practice 38, 1

You use ketamine. I use ketamine. We all use ketamine. But… how safe it is, really? A new study out of Toronto suggests 30% of patients who receive ketamine have adverse events, a rate higher than seen in the ED. What are we to make of this? I bring Dr Remle Crowe on to discuss…Citations:1.     Kwong JL, Verbeek PR, Leong YC, Turner L, Huiskamp M, Drennan IR, Francom S, Ropp S, Cheskes S: Paramedic use of ketamine for severe agitation and violence. Can J Emerg Med. doi: 10.1007/s43678-025-00963-w (Epub ahead of print).2.     Fernandez AR, Bourn SS, Crowe RP, Bronsky ES, Scheppke KA, Antevy P, Myers JB: Out-of-Hospital Ketamine: Indications for Use, Patient Outcomes, and Associated Mortality. Annals of Emergency Medicine. 2021;78(1):123–31.3.     Brown LH, Crowe RP, Pepe PE, Miller ML, Watanabe BL, Kordik SS, Wampler DA, Page DI, Fernandez AR, Bourn SS, et al.: Adverse events following emergent prehospital sedation of patients with behavioral emergencies: A retrospective cohort study. The Lancet Regional Health - Americas. 2022;May;9:100183.

Mast cell activation syndrome (MCAS) is a confusing and often misunderstood condition. If you've ever wondered about MCAS symptoms, serum tryptase testing, or how treatments like antihistamines, sodium cromolyn, and even omalizumab fit in, this episode is here to help. We review the findings from “Management of indolent mastocytosis and mast cell activation syndrome - A clinical yardstick,” published in June 2025 in The Annals of Allergy, Asthma & Immunology. Because the paper covers both diseases, we've split it into two parts. This episode focuses on mast cell activation syndrome (MCAS). GET THE INFOGRAPHIC - summary of this episode What we cover in our episode about mast cell activation syndrome: Yardsticks explained: Why the ACAAI uses yardsticks as practical, interim guidelines before full consensus statements are available. Classifying mast cell disorders: Primary (clonal), secondary (allergy/autoimmune), and idiopathic (MCAS). MCAS diagnosis criteria: Symptoms in 2 or more organ systems, objective evidence (serum tryptase or urinary metabolites tests), and positive response to therapy. Treatment strategies: Include trigger avoidance, H1/H2 antihistamines, leukotriene blockers, mast cell stabilizers (such as cromolyn and aspirin), off-label biologics like omalizumab, and epinephrine. Neuropsychiatric symptoms: Brain fog, anxiety, and depression are common and require multidisciplinary management. The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. Made in partnership with The Allergy & Asthma Network. Thanks to Blueprint Medicines for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

A silent danger lurks within the descending thoracic aorta. While most Type B aortic dissections are managed medically, up to half of these patients will either require life-saving surgery or die within just five years. So how do we separate those who will quietly recover from those on the edge of catastrophe? How do we protect the spinal cord, bowel, and limbs from the devastating consequences of malperfusion? Join the University of Michigan Department of Vascular Surgery as they tackle the high-stakes decisions behind managing this unpredictable disease—where timing is critical, interventions are evolving, and lives hang in the balance. Hosted by the University of Michigan Department of Vascular Surgery: ·       Robert Beaulieu, Program Director ·       Frank Davis, Assistant Professor of Surgery ·       Luciano Delbono, PGY-5 House Officer ·       Andrew Huang, PGY-4 House Officer ·       Carolyn Judge, PGY-2 House Officer Learning Objectives: 1.         Discuss general approach to diagnosis and management of TBAD. 2.         Identifying high-risk features in uncomplicated TBAD and understanding their role in determining the need for surgical management. 3.         Review endovascular techniques for managing malperfusion of the limbs, viscera, and spinal cord and discuss associated decision making. References:  Authors/Task Force Members, Czerny, M., Grabenwöger, M., Berger, T., Aboyans, V., Della Corte, A., Chen, E. P., Desai, N. D., Dumfarth, J., Elefteriades, J. A., Etz, C. D., Kim, K. M., Kreibich, M., Lescan, M., Di Marco, L., Martens, A., Mestres, C. A., Milojevic, M., Nienaber, C. A., … Hughes, G. C. (2024). EACTS/STS Guidelines for Diagnosing and Treating Acute and Chronic Syndromes of the Aortic Organ. The Annals of Thoracic Surgery, 118(1), 5–115. https://doi.org/10.1016/j.athoracsur.2024.01.021 de Kort, J. F., Hasami, N. A., Been, M., Grassi, V., Lomazzi, C., Heijmen, R. H., Hazenberg, C. E. V. B., van Herwaarden, J. A., & Trimarchi, S. (2025). Trends and Updates in the Management and Outcomes of Acute Uncomplicated Type B Aortic Dissection. Annals of Vascular Surgery, S0890-5096(25)00004-4. https://doi.org/10.1016/j.avsg.2024.12.060 Eidt, J. F., & Vasquez, J. (2023). Changing Management of Type B Aortic Dissections. Methodist DeBakey Cardiovascular Journal, 19(2), 59–69. https://doi.org/10.14797/mdcvj.1171 Lombardi, J. V., Hughes, G. C., Appoo, J. J., Bavaria, J. E., Beck, A. W., Cambria, R. P., Charlton-Ouw, K., Eslami, M. H., Kim, K. M., Leshnower, B. G., Maldonado, T., Reece, T. B., & Wang, G. J. (2020). Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections. Journal of Vascular Surgery, 71(3), 723–747. https://doi.org/10.1016/j.jvs.2019.11.013 MacGillivray, T. E., Gleason, T. G., Patel, H. J., Aldea, G. S., Bavaria, J. E., Beaver, T. M., Chen, E. P., Czerny, M., Estrera, A. L., Firestone, S., Fischbein, M. P., Hughes, G. C., Hui, D. S., Kissoon, K., Lawton, J. S., Pacini, D., Reece, T. B., Roselli, E. E., & Stulak, J. (2022). The Society of Thoracic Surgeons/American Association for Thoracic Surgery Clinical Practice Guidelines on the Management of Type B Aortic Dissection. The Annals of Thoracic Surgery, 113(4), 1073–1092. https://doi.org/10.1016/j.athoracsur.2021.11.002 Papatheodorou, N., Tsilimparis, N., Peterss, S., Khangholi, D., Konstantinou, N., Pichlmaier, M., & Stana, J. (2025). Pre-Emptive Endovascular Repair for Uncomplicated Type B Dissection—Is This an Option? Annals of Vascular Surgery, S0890-5096(25)00007-X. https://doi.org/10.1016/j.avsg.2025.01.003 Trimarchi, S., Gleason, T. G., Brinster, D. R., Bismuth, J., Bossone, E., Sundt, T. M., Montgomery, D. G., Pai, C.-W., Bissacco, D., de Beaufort, H. W. L., Bavaria, J. E., Mussa, F., Bekeredjian, R., Schermerhorn, M., Pacini, D., Myrmel, T., Ouzounian, M., Korach, A., Chen, E. P., … Patel, H. J. (2023). Editor's Choice - Trends in Management and Outcomes of Type B Aortic Dissection: A Report From the International Registry of Aortic Dissection. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery, 66(6), 775–782. https://doi.org/10.1016/j.ejvs.2023.05.015 Writing Committee Members, Isselbacher, E. M., Preventza, O., Hamilton Black Iii, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Jones, W. S., Kalahasti, V., … Woo, Y. J. (2022). 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology, 80(24), e223–e393. https://doi.org/10.1016/j.jacc.2022.08.004 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

What does “great” Medical Affairs look like in 2025? We talk evidence, access, patient voice, and how to work with Commercial without crossing the promotional line. Abdul Hameed Al-Khateeb, Country Medical Director, shares practical lessons on measurement, real-world evidence, and where AI actually helps.Email to your listSubject line options (pick one):Inside Medical Affairs: From Evidence to AccessThe Missing Link Between Science and PatientsWhat Great Medical Affairs Looks Like (and How to Measure It)

We've covered pre-oxygenation strategies and intubation alot on this podcast, mayber more than anyting else. We covered the definition of FPS in E74, the DEVICE trial on DL vs VL in E75, and the PREOXI trial of NIV vs Mask Pre-oxygenation in E86. Now we have another Preoxygenation paper, this one that reports no difference between preoxygenation with BVM and face mask. WTAF? Better listen, because it turns out words matter, definitions are... definitional, and we absolutely MUST read more than just the abstract.  Citations:1.     Gottlieb M, Alexander R, Love AK: Comparison of Preoxygenation Strategies for Intubation of Critically Ill Patients. Annals of Emergency Medicine. doi: 10.1016/j.annemergmed.2025.06.621 (Epub ahead of print).2.     Chou CD, Palakshappa JA, Haynie H, Garcia K, Long D, Gibbs KW, White HD, Ghamande S, Dagan A, Stempek S, et al.: Association of Two Preoxygenation Approaches With Hypoxemia During Tracheal Intubation: A Secondary Analysis. Annals of Emergency Medicine. doi: 10.1016/j.annemergmed.2025.06.003 (Epub ahead of print).3.     Pitre T, Liu W, Zeraatkar D, Casey JD, Dionne JC, Gibbs KW, Ginde AA, Needham-Nethercott N, Rice TW, Semler MW, et al.: Preoxygenation strategies for intubation of patients who are critically ill: a systematic review and network meta-analysis of randomised trials. The Lancet Respiratory Medicine. 2025;July;13(7):585–96.4.     Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, Resnick-Ault D, White HD, Gandotra S, Doerschug KC, et al.: Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. doi: 10.1056/NEJMoa2313680 (Epub ahead of print).5.     Prekker ME, Driver BE, Trent SA, Resnick-Ault D, Seitz KP, Russell DW, Gaillard JP, Latimer AJ, Ghamande SA, Gibbs KW, et al.: Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2023;June 16;389(5):418–29.6.     Trent SA, Kaji AH, Carlson JN, McCormick T, Haukoos JS, Brown CA, National EARI: Video Laryngoscopy is Associated With First-Pass Success in Emergency Department Intubations for Trauma Patients: A Propensity Score Matched Analysis of the National Emergency Airway Registry. Ann Emerg Med. doi: 10.1016/j.annemergmed.2021.07.115 (Epub ahead of print).

Qianlong's empire shines as a beacon of both martial might and cultural splendor, yet its mirrored glory hides truths too fragile for celestial ambitions. Time Period Covered: ~1770-1799CE Major Historical Figures: Qing Empire: The Qianlong Emperor (Aisin-Gioro Hongli) [r. 1735–1796, d. 1799] Grand Councillor Heshen [1750-1799] Great Britain: Lord George Macartney (1737-1806) Major Sources Cited: Bland, J.O.P. and Lord Edmund Backhouse. Annals and Memoirs of the Court at Peking. Fairbank, John King, and Denis Twitchett, eds. The Cambridge History of China, Volume 9, Part 1: The Ch'ing Empire to 1800. Perdue, Peter. China Marches West: The Qing Conquest of Central Eurasia. Woodside, Alexander. The Qing in the Age of Confucian Empire. Yuan, Wei. Shengwu ji (Sacred Military Achievements). Learn more about your ad choices. Visit megaphone.fm/adchoices

US Health Secretary RFK Jr's call to retract a study on childhood vaccines is resisted by the journal. Also antibiotics get designed by AI, and a new way for stars to die. A study focussing on Danish childhood vaccination data has attracted the US Secretary for Health's anger, as RFK jr calls for the journal in which it was published, the Annals of Internal Medicine, to retract it. The Editor, Christine Laine, talk to Science in Action about the strengths and challenges of observational studies. The cuts to prestigious US federal science funded research continue, as last week it was announced that $500 million funding for future mRNA vaccines would be withdrawn. Barney Graham, one of the pioneers in the field and prominent during the Covid vaccines, argues that the research will still happen, though maybe not in the US, as mRNA has become a fundamental area of global research. Meanwhile, strides are being made in the field of synthetic biology as Jim Collins and colleagues at MIT and Harvard have used AI to design potentially viable antibiotics for two important drug-resistant superbugs. Previously, AI has been used to comb through libraries of known antibiotics. This study has gone a step further, and used generative AI to design new ones, that can then be synthesised using real chemicals. Though a long way from being prescribable drugs, the team think this could herald a new golden age of antibiotic development – something which has been lacking in recent decades. Finally, it seems astronomers may have discovered a new way for a star to die, sort of. Supernova 2023zkd was seen to explode back in 2023, found by a team looking for odd events. It didn't seem quite like normal supernovae, in that it took a bit longer to die down. Then the team looked back, and noticed that it had also been getting slowly brighter for almost a year. At 730 million light years away, in a galaxy far, far away, it also seemed to have been stripped of all its hydrogen and even stranger yet, appeared to have exploded twice. As Ashley Villar of the Harvard Smithsonian Center for Astrophysics explains, the almost unique observation fits with a model of the huge star getting closer to a black hole, the gravity of which may have disrupted the star enough to cause it to explode. Presenter: Roland Pease Producer: Ella Hubber with Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: Child getting a vaccine. Credit: Luis Alvarez via Getty Images)

On this episode, the podcast crew discusses the recent introduction of video laryngoscopy with recording capability at MCHD. What device did you use? How did you train? What lessons have you learned? All these and more will be addressed and answered. REFERENCES: 1. Zhao, Y., Zang, B., & Wang, Q. (2024). The Effectiveness of Bougie Use on First-Attempt Success in Tracheal Intubations. Annals of emergency medicine, 84(3), 331–332. 2. Weingart, S. D., Barnicle, R. N., Janke, A., Bhagwan, S. D., Tanzi, M., McKenna, P. J., Bracey, A., & Resuscitationists Research Group (2023). A taxonomy of key performance errors for emergency intubation. The American journal of emergency medicine, 73, 137–144.

Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I SURPASS CVOT This Week in Cardiology Podcast, August 1 https://www.medscape.com/viewarticle/1002781 Mounjaro Appears More Heart Protective Than Trulicity in Trial Of Eli Lilly Diabetes Drugs https://www.medscape.com/s/viewarticle/mounjaro-proves-more-heart-protective-than-trulicity-trial-2025a1000kct II Catheter and Surgical AF ablation Catheter and Surgical Ablation for AF: Meta-Analysis https://www.acpjournals.org/doi/10.7326/ANNALS-25-00253 III Watchman Air Embolism Alerts Looming Pay Cut to LAAO Triggers Objection From Card Groups https://www.medscape.com/viewarticle/looming-pay-cut-laao-triggers-objection-card-groups-2025a1000l0j FDA Alert https://www.fda.gov/medical-devices/medical-device-recalls/early-alert-watchman-access-system-issue-boston-scientific IV Switching Oral Anticoagulants in Frail Older Adults Patients FRAIL AF Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066485 COMBINE AF Substudy https://doi.org/10.1016/j.jacc.2025.05.060 The Most Important Study From ESC: FRAIL-AF https://www.medscape.com/viewarticle/996063 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

16th-century Swiss physician Paracelsus was frustrated with established medical practice and academia and he was sometimes on the lam because of his beliefs. He wrote at length about the idea that items in the natural world carried “signatures” in their appearance that could tell you visually how they could be used medicinally. Research: Bennett, B.C. Doctrine of Signatures: An explanation of medicinal plant discovery or Dissemination of knowledge?. Econ Bot 61, 246–255 (2007). https://doi.org/10.1663/0013-0001(2007)61[246:DOSAEO]2.0.CO;2 Dafni, Amots, and E. Lev. “The Doctrine of Signatures in Present-Day Israel.” Economic Botany, vol. 56, no. 4, 2002, pp. 328–34. JSTOR, http://www.jstor.org/stable/4256605 “The Doctrine Of Signatures.” The British Medical Journal, vol. 1, no. 627, 1873, pp. 19–19. JSTOR, http://www.jstor.org/stable/25233757 “The Doctrine of Signatures.” John Moore Museum. May 11, 2021. https://www.johnmooremuseum.org/the-doctrine-of-signatures/ The Editors of Encyclopaedia Britannica. "laudanum". Encyclopedia Britannica, 19 Jul. 2025, https://www.britannica.com/science/laudanum The Editors of Encyclopaedia Britannica. "Peasants’ War". Encyclopedia Britannica, 20 Aug. 2020, https://www.britannica.com/event/Peasants-War Grzybowski, Andrzej and Katarzyna Pawlikowska-Łagód. “Some lesser-known facts on the early history of syphilis in Europe.” Clinics in Dermatology. Volume 42, Issue 2. 2024. Pages 128-133. https://doi.org/10.1016/j.clindermatol.2023.12.003. Hargrave, John G. "Paracelsus". Encyclopedia Britannica, 3 Jul. 2025, https://www.britannica.com/biography/Paracelsus “The history of syphilis part two: Treatments, cures and legislation.” Science Museum UK. Nov. 8, 2023. https://www.sciencemuseum.org.uk/objects-and-stories/history-syphilis-part-two-treatments-cures-and-legislation Kikuchihara, Y., Hirai, H. (2015). Signatura Rerum Theory. In: Sgarbi, M. (eds) Encyclopedia of Renaissance Philosophy. Springer, Cham. https://doi.org/10.1007/978-3-319-02848-4_405-1 Lund, F B. “PARACELSUS.” Annals of surgery vol. 94,4 (1931): 548-61. doi:10.1097/00000658-193110000-00009 Michaleas, Spyros N et al. “Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493-1541): The eminent physician and pioneer of toxicology.” Toxicology reports vol. 8 411-414. 23 Feb. 2021, doi:10.1016/j.toxrep.2021.02.012 Paracelsus. “Of the supreme mysteries of nature. : Of the spirits of the planets. of occult philosophy. The magical, sympathetical, and antipathetical cure of wounds and diseases. The mysteries of the twelve signs of the zodiack.” London. 1656. Accessed online: https://archive.org/details/paracelsvsofsupr00para/page/n9/mode/2up Simon, Matt. “Fantastically Wrong: The Strange History of Using Organ-Shaped Plants to Treat Disease.” Wired. July 16, 2014. https://www.wired.com/2014/07/fantastically-wrong-doctrine-of-signatures/ Tampa, M. et al. “Brief history of syphilis.” Journal of medicine and life vol. 7,1 (2014): 4-10.https://pmc.ncbi.nlm.nih.gov/articles/PMC3956094/#R6 Waite, Arthur Edward. “Lives of alchemystical philosophers based on materials collected in 1815 : and supplemented by recent researches with a philosophical demonstration of the true principles of the magnum opus, or great work of alchemical re-construction, and some account of the spiritual chemistry.” London. G. Redway. 1888. Accessed online: https://archive.org/details/livesofalchemyst1888wait See omnystudio.com/listener for privacy information.

Edwin Howard Armstrong isn’t exactly a well-known inventor, but his work in radio literally changed communications around the globe. But his most famous invention – FM radio – became a source of constant frustration after he developed it. Research: Armstrong, Edwin H. “Frequency Modulation and Its Future Uses.” The Annals of the American Academy of Political and Social Science, vol. 213, 1941, pp. 153–61. JSTOR, http://www.jstor.org/stable/1024069 Armstrong, Edwin H. “Personalities in Science.” Scientific American, vol. 154, no. 1, 1936, pp. 3–3. JSTOR, http://www.jstor.org/stable/26144367 “First public radio broadcast.” Guinness World Records. https://www.guinnessworldrecords.com/world-records/381969-first-public-radio-broadcast “FM Inventor Dies in Fall.” The Patriot News. Feb. 2, 1954. https://www.newspapers.com/image/1094174282/?match=1&terms=%22Edwin%20Howard%20Armstrong%22 Lessing, Lawrence P.. "Edwin H. Armstrong". Encyclopedia Britannica, 14 Dec. 2024, https://www.britannica.com/biography/Edwin-H-Armstrong Lessing, Lawrence P. “Man of High Fidelity: Edwin Howard Armstrong.” Bantam. 1969. Lessing, Lawrence P. “The Late Edwin H. Armstrong.” Scientific American, vol. 190, no. 4, 1954, pp. 64–69. JSTOR, http://www.jstor.org/stable/24944524 “Proceedings of the Institute of Radio Engineers, Volume 5.” Institute of Radio Engineers. 1917. Accessed online: https://books.google.com/books?id=YEASAAAAIAAJ&source=gbs_navlinks_s “Radio Broadcast.” Garden City, N.Y.: Doubleday, Page & Co., 1922-1930. https://babel.hathitrust.org/cgi/pt?id=iau.31858044013914&view=1up&seq=277 “Telephoning Without Wires.” The Fort Wayne Journal Gazette. Oct. 20, 1907. https://www.newspapers.com/image/29125618/?match=1&terms=audion%20%22de%20Forest%22 Tsividis, Yannis. “Edwin Armstrong: Pioneer of the Airwaves.” Columbia Magazine. April 1, 2002. https://magazine.columbia.edu/article/edwin-armstrong-pioneer-airwaves Turner, H. M. “Dr. Edwin H. Armstrong, Edison Medalist.” The Scientific Monthly, vol. 56, no. 2, 1943, pp. 185–87. JSTOR, http://www.jstor.org/stable/17796 “What’s the Difference Between AM and FM Radio?” National Inventors Hall of Fame. Aug, 16, 2023. https://www.invent.org/blog/trends-stem/difference-between-am-fm See omnystudio.com/listener for privacy information.