Podcasts about Annals

How do we decide who gets financial support from the government? Usually, it comes down to the federal poverty line. You might think a lot of data and research goes into establishing that number. But in reality, it’s much squishier. So squishy in fact that it involves Jello... Today, a special episode brought to us by our friends at Control F: the surprising history of the federal poverty line. Sources in this episode: U.S. Census Bureau Timeline of Poverty Measure, 2014 How the U.S. Census Bureau Measures Poverty, 2022 What does living at the poverty line look like?, USA Facts, 2023 Poverty Guidelines vs Poverty Thresholds, U.S. Department of Health and Human Services Poverty Line Matrix, U.S. Department of Health and Human Services, 2026 Remembering Mollie Orshansky — The Developer of the Poverty Thresholds, Society Security Administration, 2008 Relatively Deprived, New Yorker, 2006 Mollie Orshansky, Statistician, Dies at 91, The New York Times, 2007 Mollie Orshansky: Inventor of the Poverty Line, NPR, 2007 Thrifty Food Plan, U.S. Department of Agriculture, 2021 Thrifty Food Plan: Better planning and accountability could help ensure quality of future reevaluations, U.S. Government Accountability Office Report to Congressional Requesters, 2022 Family Food Plans and Food Costs, U.S. Department of Agriculture, 1962 The Indians in the Lobby, Season 3, Episode 8, The West Wing, 2001 NPR audience call out on SNAP benefits, 2025 Legacies of the War on Poverty, The ANNALS of the American Academy of Political & Social Science, 2024 Control F wants to answer your questions about how our world works! Click here to submit a question using their online form, or email the team at ControlF@kuow.org Do you have a tip for the Booming team? Give us a call at (206) 221-7158 and leave a voicemail. You can also email us at booming@kuow.org.Thank you to the supporters of KUOW, you help make this show possible! If you want to help out, go to kuow.org/donate/boomingnotes.Booming is a production of KUOW in Seattle, a proud member of the NPR Network. Our editor is Carol Smith. Our producers are Lucy Soucek and Alec Cowan. Our hosts are Joshua McNichols and Monica Nickelsburg.Support the show: https://kuow.org/donateSee omnystudio.com/listener for privacy information.

Wie kann uns „Achtsames Selbstmitgefühl“ unterstützen, in herausfordernden Beziehungen auf gesunde Art und Weise mit schwierigen Gefühlen (wie Wut) umzugehen? Wie kann ich in helfenden Berufen oder wenn ich mich zuhause um jemanden kümmere, liebevoll und verbunden bleiben, ohne dabei auszubrennen? Sinja und Cäcilia sprechen über die Möglichkeiten für einen mitfühlenden Umgang in herausfordernden zwischenmenschlichen Momenten. Es geht dabei auch um die sogenannte „Fürsorgemüdigkeit“, den Unterschied zwischen Empahtie und Mitgefühl und wie uns Gleichmut helfen kann.Umfrage: Wie gefällt dir Verstehen, fühlen, glücklich sein? Erzähle es uns ⁠⁠⁠⁠⁠hier⁠⁠⁠⁠⁠.Hintergründe und Studien:Zu MSC-Kursen geht es: Hier Gallese, V., Eagle, M. N., & Migone, P. (2007). Intentional attunement: Mirror neurons and the neural underpinnings of interpersonal relations. _Journal of the American psychoanalytic Association_, _55_(1), 131-175. Link zur Studie Rizzolatti, G., Fadiga, L., Gallese, V., & Fogassi, L. (1996). Premotor cortex and the recognition of motor actions. _Cognitive brain research_, _3_(2), 131-141. Link zur Studie Bernhardt, B. C., & Singer, T. (2012). The neural basis of empathy. _Annual review of neuroscience_, _35_, 1-23. Link zur Studie Cacioppo, J. T., & Decety, J. (2011). Social neuroscience: challenges and opportunities in the study of complex behavior. _Annals of the New York Academy of Sciences_, _1224_(1), 162-173. Link zur Studie Saarela, M. V., Hlushchuk, Y., Williams, A. C. D. C., Schürmann, M., Kalso, E., & Hari, R. (2007). The compassionate brain: humans detect intensity of pain from another's face. _Cerebral cortex_, _17_(1), 230-237. Link zur Studie Klimecki, O. M., Leiberg, S., Ricard, M., & Singer, T. (2014). Differential pattern of functional brain plasticity after compassion and empathy training. _Social cognitive and affective neuroscience_, _9_(6), 873-879. Link zur Studie Leiberg, S., Klimecki, O., & Singer, T. (2011). Short-term compassion training increases prosocial behavior in a newly developed prosocial game. _PloS one_, _6_(3), e17798. Link zur Studie Stebnicki, M. A. (2007). Empathy fatigue: Healing the mind, body, and spirit of professional counselors. _American journal of psychiatric rehabilitation_, _10_(4), 317-338. Link zur Studie

Die akute Herzinsuffizienz ist häufig die gemeinsame Endstrecke ganz unterschiedlicher Erkrankungen. Umso wichtiger ist es, die zugrunde liegenden Ursachen zu erkennen und die Zeichen einer kardialen Dekompensation richtig zu deuten.In dieser Folge von Rettungsdienst LUKS – der Notfallmedizin Podcast widmen wir uns der Pathophysiologie der akuten Herzinsuffizienz. Anhand des Akronyms CHAMPIT strukturieren wir die häufigsten Ursachen einer akuten Dekompensation und unterscheiden vier klinische Phänotypen – warm, kalt, feucht und trocken – als Grundlage für die initiale Therapiestrategie in der Präklinik.Rettungsdienst LUKS – Der Notfallmedizin Podcast mit dem Thema: Wenig vorwärts, viel rückwärts - Herzinsuffizienz systematisch erklärtIn dieser Folge: - Pathophysiologie der Herzinsuffizienz. Symptomatik des Vorwärts- und des Rückwärtsversagens- Ursachenforschung zur akuten Herzinsuffizenz mit dem Akronym CHAMPIT- Warm, kalt, feucht oder trocken? Anhand der vier Phänotypen die Herzinsuffizenz richtig TherapierenHomepage des Rettungsdienst LUKSLink zur letzten Folge zum Thema: Adieu „Grand mal“ – Neuroanatomie, Klinik und Semiologie epileptischer Anfälle  (und zu allen anderen Folgen)Alle Evidenzen zu dieser Folge findest du hier: Schmitt, D., & Güder, G. (2021). Die akute Herzinsuffizienz: Weit mehr als nur ein kardiales Problem. Notfallmedizin up2date, 16(03), 299–321. https://doi.org/10.1055/a-1341-6616Silvers, S. M., Gemme, S. R., Hickey, S., et al. (2022). Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Heart Failure Syndromes. Annals of Emergency Medicine, 80(4), e31–e59. https://doi.org/10.1016/j.annemergmed.2022.05.027Heidenreich, P. A., Bozkurt, B., Aguilar, D., et al. (2022). 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. Journal of the American College of Cardiology, 79(17), e263–e421. https://doi.org/10.1016/j.jacc.2021.12.012Theresa A McDonagh, Marco Metra, Marianna Adamo, Roy S Gardner et al., 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC, European Heart Journal, Volume 44, Issue 37, 1 October 2023, Pages 3627–3639, https://doi.org/10.1093/eurheartj/ehad195Tharmaratnam, G., Wunderl, M., Schebler, K., Jacko, T., Hossfeld, B., & Gässler, H. (2020). Die vier Schockformen – Teil 2: Kardiogener Schock. Der Notarzt, 36(01), 46–53. https://doi.org/10.1055/a-0991-5525Van Der Meer, P., Gaggin, H. K., & Dec, G. W. (2019). ACC/AHA Versus ESC Guidelines on Heart Failure. Journal of the American College of Cardiology, 73(21), 2756–2768. https://doi.org/10.1016/j.jacc.2019.03.478Bundesärztekammer, Kassenärztliche Bundesvereinigung und Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften. Nationale VersorgungsLeitlinie Chronische Herzinsuffizienz – Langfassung, 2019; 3. Auflage. doi:10.6101/AZQ/000465. Im Internet (Stand: 22.07.2021): https://www.leitlinien.de/themen/herzinsuffizienzDisclaimerDie Inhalte des Podcast Rettungsdienst LUKS - Der notfallmedizin Podcast sind rein akademisch. Sie dienen nur Informations-, Lern- und Trainingszwecken und sind für ärztliches Personal, Rettungssanitäter:innen und andere im Gesundheitswesen und der Akutmedizin Tätige bestimmt. Die Inhalte sind nicht zur Behandlung realer Fälle geeignet und ersetzen keinen Arztbesuch. Der Podcast wird mit größtmöglicher Sorgfalt erstellt. Das Luzerner Kantonsspital übernimmt jedoch keine Gewähr für die Richtigkeit, Vollständigkeit und Aktualität der Inhalte.

This week on the Nutshell , Daisy and Clare discuss whether paying more for organic produce pays off in terms of health benefits. There are lots of things to think about from pesticide burden to the nutrient values in the foods themselves. But with ever rising food bills,  should you prioritise organic, or can we afford not to? Smith-Spangler C, Bravata DM, Hunter-Goren A, et al.“Are organic foods safer or healthier than conventional alternatives? A systematic review.”Annals of Internal Medicine, 2012; 157(5):348–366.DOI: 10.7326/0003-4819-157-5-201209040-00007Baranski M, Średnicka-Tober D, Volakakis N, et al.Higher antioxidant and lower cadmium concentrations and lower incidence of pesticide residues in organically grown crops: a systematic literature review and meta-analyses.British Journal of Nutrition. 2014;111(5):794–811.doi: 10.1017/S000711451300284XBaudry, J., Assmann, K. E., Touvier, M., Allès, B., Seconda, L., Latino-Martel, P., Hercberg, S. (2018). Association of frequency of organic food consumption with cancer risk: Findings from the NutriNet-Santé prospective cohort study.mJAMA Internal Medicine, 178(12), 1597–1606.https://doi.org/10.1001/jamainternmed.2018.4357https://www.ewg.org/foodnews/dirty-dozen.phphttps://www.pan-europe.info/https://www.pan-uk.org/https://hodmedods.co.uk/If you'd like to support our work and be part of a growing community of like-minded people working towards creating a healthier and more sustainable future please join the Plant-Based Health Professionals UK following the link below:https://plantbasedhealthprofessionals.com/membershipYou don't have to be a health care professional to join, but by doing so you're not only supporting our work, you'll be improving your own health;  with membership starting from as little as £15 a year, join us now and be part of the change you want to see.

In this new episode of Speaking of Surgonc, Dr. Rick Greene & Dr. Elena Panetti discuss the article: Short- and Long-Term Outcomes After Hepatectomy in Patients Receiving Triplet Versus Doublet Preoperative Chemotherapy for Colorectal Liver Metastases, from the January 2026 issue of the Annals of Surgical Oncology.

Robotic surgery has moved from novelty to norm, and in this episode of Behind the Knife, Drs. James Jung and Joey Lew sit down with urologic pioneer and Medtronic CMO Dr. Jim Porter to dissect how we got here, what the data really say about “the death of laparoscopy,” and where competing robotic platforms like Hugo may take the field next. From ergonomics and education to economics and global access, they tackle both the hype and the hard questions around robotics as the future of minimally invasive surgery.Hosts: ·      James Jung, MD, PhD, Assistant Professor of Surgery, Duke University·      Joey Lew, MD, MFA, Surgical resident PGY-3, Duke University, @lew__actuallyLearning Goals: By the end of this episode, listeners will be able to:·      Describe key clinical, ergonomic, and educational drivers behind the rapid adoption of robotic surgery in the United States and globally.·      Summarize current evidence comparing robotic and laparoscopic approaches for common procedures, including where outcomes are equivalent, inferior, or clearly superior.·      Explain how surgeon ergonomics, trainee experience, and video-based learning influence practice patterns and learning curves in minimally invasive surgery.·      Discuss the role of cost, reimbursement structures, and market competition (e.g., Medtronic Hugo vs da Vinci) in shaping robotic adoption across different health systems.·      Anticipate how next-generation, task- or organ-specific robotic platforms may further change standards of care in minimally invasive surgery.References:·      Violante T, Ferrari D, Novelli M, Larson DW. The Death of Laparoscopy - Volume 2: A Revised Prognosis. A retrospective study. Ann Surg. 2025 Jun 16. doi: 10.1097/SLA.0000000000006792. Epub ahead of print. PMID: 40518997. https://pubmed.ncbi.nlm.nih.gov/40518997/·      Yu Yoshida, Yoshiro Itatani, Takehito Yamamoto, Ryosuke Okamura, Koya Hida, Kazutaka Obama, Single-incision plus one robot-assisted surgery (SIPORS) using the Hugo robotic-assisted surgery (RAS) system for rectal cancer, Annals of Coloproctology, 10.3393/ac.2025.00787.0112, 41, 6, (586-591), (2025). https://pubmed.ncbi.nlm.nih.gov/41486916/Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

Listener discretion is advised. References: Varney J, Motawea KR, Mostafa MR, AbdelQadir YH, Aboelenein M, Kandil OA, Ibrahim N, Hashim HT, Murry K, Jackson G, Shah J, Boury M, Awad AK, Patel P, Awad DM, Rozan SS, Talat NE. Efficacy of heads-up CPR compared to supine CPR positions: Systematic review and meta-analysis. Health Sci Rep. 2022 May 24;5 Norii T, Lukas G, Samantaray A, Yabuki M, Olasveengen TM, Bray JE; International Liaison Committee on Resuscitation ILCOR Basic Life Support Task Force. Effects of head-up CPR on survival and neurological outcomes: A systematic review. Resusc Plus. 2025 Jun 16 Kim DW, Choi JK, Won SH, Yun YJ, Jo YH, Park SM, Lee DK, Jang DH. A new variant position of head-up CPR may be associated with improvement in the measurements of cranial near-infrared spectroscopy suggestive of an increase in cerebral blood flow in non-traumatic out-of-hospital cardiac arrest patients: A prospective interventional pilot study. Resuscitation. Huang CC, Chen KC, Lin ZY, Chou YH, Chen WL, Lee TH, Lin KT, Hsieh PY, Chen CH, Chou CC, Lin YR. The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis. Crit Care. 2021 Oct 30;25(1):376. Swaminathan, A., Mohan, M. (2023). Heads Up! Data Dredging Coming Through: Heads Up Cardiopulmonary Resuscitation Does Not Improve Outcomes. February 2023 Annals of Emergency Medicine Journal Club

Join host David Watson for a candid and wide-ranging conversation with his returning guest, author Martin R. Nelson. In this episode, they tackle everything from the universal comfort of cookies and milkshakes to the heavy burdens of self-doubt and financial struggle. Martin opens up about his hectic life juggling a full-time teaching job, a move, and a second child on the way, all while promoting his latest high-fantasy novel, The Culling of Souls, the sequel to Children of the Dying Hearth. He shares the profound themes of his Annals of Tessian series, exploring how characters must leave their comfort zones and "cull their souls" to grow. The discussion then pivots to the harsh realities of the creative world. Martin and David have a raw and honest talk about the challenges of indie publishing, the feeling of creating for an empty stadium, and the constant battle with the question: "What will people think?" They also dive into broader societal issues, touching on the housing market, the paradox of tolerance, and the state of free speech and politics in the UK and beyond. This is a must-watch for aspiring authors, fantasy fans, and anyone who has ever questioned their own worth or path in life. Timestamps: 0:00 - Intro & Martin's Busy Life 1:45 - The Power of Cookies & Milkshakes 7:00 - The Gift That Gets You Out of Trouble 10:16 - The Male Struggle with Self-Worth & Spending 12:36 - David's Story: Bankruptcy and Homelessness 17:08 - Then vs. Now: The Housing Market Crisis 19:00 - The Frugal Path to Home Ownership 24:04 - The Man Who Chose Status Over Freedom 29:58 - The Problem with Class and Status Systems 34:02 - The Japanese Mindset of Service 45:00 - Airport Horror Stories 51:19 - Focusing on the Books! 52:10 - Introducing the Annals of Tessian Series 58:45 - The Theme of Children of the Dying Hearth 1:00:12 - The Theme of The Culling of Souls 1:03:00 - Trauma, Growth, and Using Emotions as a Window 1:09:15 - The Creator's Dilemma: Self-Doubt & The Empty Stadium 1:18:03 - The Gatekeepers of Publishing & The Noise of Indie Authorship 1:25:15 - The Power of a "Body of Work" 1:31:00 - The Humanizing Power of a Conversation 1:49:00 - Tolkien, Politics, and the Real-World Scouring of the Shire 1:55:00 - The State of Free Speech in the UK 2:06:00 - The Epstein Files, Legal Realities, and Systemic Corruption 2:19:50 - A Ruler's True Role: To Serve 2:22:59 - Outro Find Martin's Books: https://martinraynelson.com/

Fantasy author Martin R. Nelson joins David Watson for a candid conversation about the brutal reality of the creative life, the deep themes in his high fantasy series "The Annals of Tessian," and the relentless struggle to get noticed in a saturated world. We dive into his new book, "The Culling of Souls," and its predecessor, "Children of the Dying Hearth," exploring the powerful ideas that fuel them. Martin breaks down how the first book is about the courage to leave your comfort zone—a theme embodied by a teenage boy who might be the heir to a lost empire, a 600-year-old elf who's still just a kid, and a noble ruler forced to get his hands dirty. The sequel, "The Culling of Souls," tackles a more internal battle: the painful but necessary act of cutting away the parts of yourself that hold you back, like a traumatic memory that no longer has to define your tomorrow. This isn't just a book talk; it's a raw look into the heart of an indie author. Martin opens up about the crushing self-doubt that comes with asking people to buy your work, the frustration of hitting a wall with gatekeepers and expensive (and sometimes useless) editorial reviews, and the overwhelming noise of 4,000+ books published every single day. He shares the "empty stadium" feeling of creating incredible work with no crowd watching, and the crucial difference between an athlete's measurable "personal best" and a creator's invisible race. But the conversation is also filled with hope and hard-won wisdom. They discuss the power of building a "body of work" and waiting for that one brick to be knocked out of the wall, as described by podcaster Dan Carlin, so the people on the other side can finally see you. Martin shares stories from the band Stereophonics about how their biggest hit was a song they almost threw away, proving that sometimes you just have to keep showing up. They also touch on the practical side of book promotion, debating the merits of targeted Amazon ads versus scattergun PR and the hilarious potential (and pitfalls) of using AI to create promotional videos. If you're a writer, artist, or anyone trying to create something meaningful, this episode is a must-watch. It's a testament to the idea that even if the stadium is empty, you have to lace up your boots and run the race anyway—because the only thing you can control is showing up for tomorrow. Timestamps: 0:00 - The Indie Author's Dilemma 1:09 - Introducing Martin R. Nelson & "The Annals of Tessian" 2:18 - The Theme of "Children of the Dying Hearth": Leaving Your Comfort Zone 4:45 - The 600-Year-Old Elf: A Fun Fantasy Trope 6:00 - The Honorable Ruler Who Needs to Get His Hands Dirty 8:14 - The Bilbo Baggins Principle: No Hero's Journey from an Armchair 9:07 - "The Culling of Souls": Cutting Away What Holds You Back 11:13 - The Trauma That Defines You vs. The Trauma You Learn From 14:34 - Emotions Are a Window to the Soul 16:11 - The Truman Show: How Trauma Traps You 17:02 - The Universal Struggle: Jesus, Buddha, and Marcus Aurelius 18:36 - The Crushing Self-Doubt of Selling Your Own Work 20:11 - The Joe Rogan Comparison & The Empty Stadium 22:50 - The Athlete's "Personal Best" vs. The Creator's Invisible Race 24:02 - Van Gogh, Bob Ross & Finding Success After You're Gone 26:25 - The Power of a Good Conversation (and Respecting Boundaries) 29:01 - The Stereophonics Story: "Just Some Shit" Becomes a Hit 32:13 - Dan Carlin's "Wall" Theory & the Body of Work 34:39 - The Gatekeepers: Agents, Publishers, and 4,000 Daily Books 38:10 - The $700 Kirkus Review That Was Total Garbage 40:06 - AI Video Promotion: Hilarious Failures & Huge Potential 43:56 - Amazon Ads: Targeting the Right Niche 45:05 - The Power of the "Everyman" Podcast 48:06 - Turning Up the Volume for the RIGHT People 51:00 - The Fascination with the "Everyman" in History 52:28 - How You Can Support Indie Authors Martin https://martinraynelson.com/

Contributor: Aaron Lessen, MD Educational Pearls: What is anaphylaxis and what are its treatments?  Anaphylaxis is a broad term for potentially life threatening allergic reactions that can progress to cardiovascular collapse (anaphylactic shock).  It is triggered by IgE and antigen cross-linking on mast cells to induce degranulation and the release of histamines, which can cause diffuse vasodilation and respiratory involvement with end-organ hypoperfusion. First line treatment is the immediate administration of epinephrine at 0.01 mg/kg (max dose for pediatrics is 0.3 mg and for adults is 0.5 mg) as well as removal of the offending agent causing the reaction. Additional pharmacologic treatments such as anti-histamines and steroids should be considered but not used instead of epinephrine when anaphylactic shock is evident as the sole therapy. What is biphasic anaphylaxis and what is its occurrence? Biphasic anaphylaxis is the return of anaphylactic symptoms after the initial anaphylactic event. Previous studies have reported an incidence ranging from 1-20% of patients having an initial anaphylactic reaction having biphasic anaphylaxis, at a range of time from 1-72 hours. The mechanism of biphasic anaphylaxis is not completely known, but can be contributed to by initial interventions wearing off (and why patients will be monitored for 2-4 hours after initial symptoms and treatment), or delayed immune mediators beginning to take effect. Recent studies show that the rate of biphasic anaphylaxis may be closer to 16% occurrence with a median time of occurrence being around 10 hours. What is the key take away and patient education on biphasic anaphylaxis? After patients have been observed for the initial 2-4 hours in the emergency room, they are generally safe to go home. Patients should be informed of the need to carry an Epi-Pen for similar anaphylactic reactions, and informed that there is a chance within the next day (10-20 hours) that they may have the symptoms occur once again. The biphasic reaction may be more mild, and patients should be educated on how to treat it and to seek immediate emergency care if the symptoms do not improve. References Golden DBK, Wang J, Waserman S, et al. Anaphylaxis: A 2023 practice parameter update. Annals of Allergy, Asthma & Immunology. 2024;132(2):124-176. doi:10.1016/j.anai.2023.09.015 Rubin S, Drowos J, Hennekens CH. Anaphylaxis: Guidelines From the Joint Task Force on Allergy-Immunology Practice Parameters. afp. 2024;110(5):544-546. Weller KN, Hsieh FH. Anaphylaxis: Highlights from the practice parameter update. CCJM. 2022;89(2):106-111. doi:10.3949/ccjm.89a.21076 Gupta RS, Sehgal S, Brown DA, et al. Characterizing Biphasic Food-Related Allergic Reactions Through a US Food Allergy Patient Registry. The Journal of Allergy and Clinical Immunology: In Practice. 2021;9(10):3717-3727. doi:10.1016/j.jaip.2021.05.009 Summarized by Dan Orbidan OMS2 | Edited by Dan Orbidan & Jorge Chalit OMS4 Donate: https://emergencymedicalminute.org/donate/ Join our mailing list: http://eepurl.com/c9ouHf

Ticagrelor vs prasugrel, a new LAAC device, pulsed field ablation AF results, lifestyle intervention in AF, the term "provider" vs "doctor," and coffee are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I TUXEDO-2 Trial TUXEDO-2 Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2844869 ISAR-REACT 5 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973 II VERITAS Study of Dual-Seal LAAO VERITAS Study https://doi.org/10.1016/j.jacep.2026.01.021 III PFA vs RF over 4 years Advent-LTO study https://www.nature.com/articles/s41591-026-04246-4 ADVENT Study https://www.nejm.org/doi/full/10.1056/NEJMoa2307291 SPHERE PER-AF Study https://www.nature.com/articles/s41591-024-03022-6 SINGLE SHOT CHAMPION Study https://www.nejm.org/doi/full/10.1056/NEJMoa2502280 BEAT PAROX-AF Trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829 IV What's in a Name — Use of the Term "Provider" Physicians Are Not Providers: The Ethical Significance of Names https://www.acpjournals.org/doi/10.7326/ANNALS-25-03852 V Coffee and Dementia Risk Coffee/Tea Intake and Dementia Risk https://jamanetwork.com/journals/jama/fullarticle/2844764 Mandrola Commentary: Enough With the Coffee Research and Other Distractions https://www.medscape.com/viewarticle/883709 VI Lifestyle interventions Post AF ablation Improving Outcomes of AF by Lifestyle Interventions https://academic.oup.com/eurheartj/article/47/6/669/8243674 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (From Wikipedia.)This is a collaborative reading.Translated by Alfred J. Church and William J. Brodribb.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (From Wikipedia.)This is a collaborative reading.Translated by Alfred J. Church and William J. Brodribb.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (From Wikipedia.)This is a collaborative reading.Translated by Alfred J. Church and William J. Brodribb.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (From Wikipedia.)This is a collaborative reading.Translated by Alfred J. Church and William J. Brodribb.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (From Wikipedia.)This is a collaborative reading.Translated by Alfred J. Church and William J. Brodribb.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (From Wikipedia.)This is a collaborative reading.Translated by Alfred J. Church and William J. Brodribb.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

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Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-471 Overview: Discover how flexible physical activity patterns can reduce mortality and cardiovascular risk in patients with diabetes. This episode translates evidence on “weekend warrior” vs regular exercise into practical counseling strategies, empowering you to help time-constrained patients achieve the mortality benefits of weekly moderate-to-vigorous physical activity—regardless of scheduling pattern. Episode resource links: Wu, Z., Sheng, C., Guo, Z., Zheng, Y., Zheng, D., Li, X., Guo, X., & Li, H. (2025). Association of Weekend Warrior and Other Physical Activity Patterns With Mortality Among Adults With Diabetes : A Cohort Study. Annals of internal medicine, 178(9), 1279–1286. https://doi.org/10.7326/ANNALS-25-00640 Guest: Jill M. Terrien PhD, ANP-BC  Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-471 Overview: Discover how flexible physical activity patterns can reduce mortality and cardiovascular risk in patients with diabetes. This episode translates evidence on “weekend warrior” vs regular exercise into practical counseling strategies, empowering you to help time-constrained patients achieve the mortality benefits of weekly moderate-to-vigorous physical activity—regardless of scheduling pattern. Episode resource links: Wu, Z., Sheng, C., Guo, Z., Zheng, Y., Zheng, D., Li, X., Guo, X., & Li, H. (2025). Association of Weekend Warrior and Other Physical Activity Patterns With Mortality Among Adults With Diabetes : A Cohort Study. Annals of internal medicine, 178(9), 1279–1286. https://doi.org/10.7326/ANNALS-25-00640 Guest: Jill M. Terrien PhD, ANP-BC  Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Peter Robbins returns to the show to continue our discussion about Wilhelm Reich. We talk about Peters' latest book, called Deception, and do get into varies discussion about UFO's, and then get into Reich, Cloudbusting, and UFO's.Peter Robbins was first introduced to the books of Wilhelm Reich as a teenager by a college roommate, to whom he remains deeply indebted. In 1976 he met Dr. Elsworth F. Baker, Reich's first assistant for the last eleven years of his life. Soon after this he became a patient of Dr. Baker and entered into almost seven years of medical orgone therapy with the distinguished orgonomist.Robbins went on to enroll in the classes New York University offered in scientific and social orgonomy which was taught by the Reich scholars Professors John Bell and Paul Matthews. They in turn invited him to become a member of their ongoing Seminar in Social and Scientific Orgonomy, patterned after the seminars which Sigmund Freud presided over during the nineteen twenties. Peter spent much of the nineteen eighties involved with this group, presenting a variety of papers to his fellow seminar members under Matthews' and Bell's guidance and leadership.Peter was a volunteer fundraiser for the American College of Orgonomy's (ACO) Building Fund and had two papers on Wilhelm Reich and UFOs published in the Journal of Orgonomy. He was part of a select group of volunteers invited to witness a demonstration of cloudbusting technology and presented on the subject of Reich and UFOs at the ACO's Princeton NJ facility, and at international conferences on the life and work of Reich in New York City, Ashland Oregon, Niece France and Karavomilos Greece. His lectures have been well received at numerous scientific and UFO conferences both here and abroad while his articles on the subject have been published in a variety of print and web publications. Robbins' extensively researched paper, “Politics, Religion and Human Nature: Practical Problems and Roadblocks on the Path Toward Official UFO Acknowledgment” is scheduled to be published in the upcoming issue of Annals of the Institute for Orgonomic Science. Hosted on Acast. See acast.com/privacy for more information.

Dr. Monty Pal and Dr. Atul Batra discuss the PLANeT study from India, which evaluated low-dose pembrolizumab in addition to neoadjuvant chemotherapy for triple-negative breast cancer, and its place among a growing body of international research on improving efficacy while reducing costs and toxicity with lower doses of immunotherapy. TRANSCRIPT Dr. Monty Pal: Hello and welcome to the ASCO Daily News Podcast. I'm your host, Dr. Monty Pal. I'm a medical oncologist, professor, and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center, Los Angeles. My guest today, I think, is going to be a really riveting one. It's Dr. Atul Batra, who is an additional professor of medical oncology at the All India Institute of Medical Sciences, or AIIMS, in New Delhi. And he's also the senior author of the PLANeT study. It's a very compelling study that evaluated low-dose pembrolizumab in addition to neoadjuvant chemotherapy for triple-negative breast cancer. And it's really a big part of a growing body of research that's showing balanced efficacy when we use lower doses of immunotherapy instead of standard doses to reduce cost, as well as potentially toxicity. I think this has huge implications for our global audience, and I'm so thrilled to have you on the podcast today, Dr. Atul Batra, welcome. Dr. Atul Batra: Thank you, Dr. Pal. Dr. Monty Pal: And we'll just take it with first names from here since we're both friends. I have to give the audience some context. Atul, I had the great honor of visiting AIIMS New Delhi. For those that don't know, this is really, you know, the Harvard Medical School of India. It's the most competitive institution for medical training. And on the back end of that, there's also incredible resources when it comes to clinical trials and infrastructure. I just wanted to have you give the audience sort of a scope of the types of trials that you've been able to do at AIIMS New Delhi. Dr. Atul Batra: Thank you, Monty. So, I work at the All India Institute of Medical Sciences, and we had the honor and pleasure of having Monty here this month. And people are still in awe of his lectures that he delivered there. Coming back to our institute, so it's kind of a medical college. It's one of the oldest ones, it was built in 1956. We are lucky enough that we get the best of the residents and fellows because they have to go through an exam, a competitive exam, and mostly it's them who come to us and we're able to do some good work out here. Regarding the trials that we have conducted, we do conduct some investigator-initiated studies, and we try to answer the questions where we can help our own patients. Like, for example, this PLANeT study. Every other patient in the clinic was almost not able to afford Keytruda at the full dose, pembrolizumab, and we had a lot of evidence creeping in that a lower dose might be helpful. And that's how we planned this study. Before that, there are certain cancers that are peculiar to India, like gallbladder cancer, head and neck cancers. These are much more common in India as compared to the U.S., and there are some good studies that have been conducted from our own institute by our senior colleagues which have been presented at ASCO and published in the JCO. We also did the capecitabine hand-foot syndrome study that was known as the D-ToRCH study: 1% diclofenac gel that became the standard of care to prevent hand-foot syndrome.  So, that's kind of a brief overview of investigator-initiated studies. India is slowly and steadily becoming a partner of the global registration trials. And it's more recently, the last five years or so, we have seen that the number of phase 2 and phase 3 trials are increasing and we are able to offer now these trials as well to our patients. Dr. Monty Pal: That was a terrific overview. I just want to highlight for the audience, as we go through some of your discussions today around specific trials, the speed at which this can be done. Just for context, for me to accrue a clinical trial of 30 patients – I think many people have probably come across some of the work that I've done in the microbiome space – at a single institution, 30 patients, right, takes me about a year and a half, two years. We're going to go through some trials today where Dr. Batra and his team have actually, in fact, accrued close to 200 patients over a span of just a year, which is just remarkable by, I would say, any American standard. So, I see a real need for partnership and Atul, I'll kind of get back to that at the end. But without further ado, the focus of this podcast today, I think, is really this terrific presentation you gave in an oral session at ESMO and subsequently published in Annals of Oncology related to the PLANeT study. Would you give the listeners some context around what the study entailed and population and so forth? Dr. Atul Batra: So, we know the KEYNOTE-522 became the standard of care for triple-negative breast cancer, where Keytruda, when added at 200 mg, the standard dose every three weeks with neoadjuvant, increases the pCR from around 51% to 64% by a magnitude of around 13%. However, in India and other low-middle income countries, less than 5% of the patients actually have access to this dose of pembrolizumab. So, our standard of care was actually just chemotherapy till now. And this kind of led us to design this trial. There are data that come from previous trials conducted in India, from the Tata Memorial, done in head and neck space, some other studies done in Hodgkin's lymphoma, that a much lower dose, probably around one-tenth of the dose, works well in these cancers. So, that's where we designed the PLANeT study, where we gave the standard neoadjuvant chemotherapy in the control arm, and in the experimental arm we added 50 mg of pembrolizumab. This was given every six weeks for three doses. So, that's a total of 150 mg over the neoadjuvant period as compared to 1,600 mg that was given in the KEYNOTE-522 study. So, this was almost one-tenth of the study. Dr. Monty Pal: So, a tenth of the dose, which is just remarkable. I mean, that's just such an interesting concept. Dr. Atul Batra: And the results, when we – the primary outcome, this was a phase 2 study. We just wanted to see, is there a signal of activity? And to even our surprise, when we looked at the pathological complete response rates, in the control arm this was 40.5%, and in the experimental arm this was 53.8%. So, a difference came to around 13.3%; it was numerically, I mean, so much similar to what KEYNOTE-522 had with just these many doses. So, this was around 160 patients randomized over one year. We could randomize them in one year because of the load that we see. And the primary endpoint was met, and we could see that the path complete response did show a remarkable increase. We are still following these patients to see whether there is a difference in event-free survival at a longer follow-up. Until now, it's a small follow-up, so the number of events absolute, are different: four events in the experimental arm and 11 events in the control arm. So, we are seeing some signal even in this much short follow-up period as well. But we need to see more of what happens in the longer term. Dr. Monty Pal: That's so impressive. I wonder, with this lower dose, do you attenuate toxicity at all as far as you can gather? Dr. Atul Batra: So, although we shouldn't be doing kind of cross-trial comparisons, but if you look at thyroid dysfunction, we saw that around 10% of our patients had this thyroid dysfunction. This was compared to 15% in the KEYNOTE-522, that was a larger sample size though. But we're seeing that all the toxicities are somewhat less as compared to those in the standard dose. So, the exposure is less, but I mean, I can't really commit definitely on this. For this we would need much more data to say this with more confidence. Dr. Monty Pal: Yeah. I'm going to ask you a really tough question to follow up, and this is probably something that's on everyone's mind after reading a study like this. Is this something that is disease-specific that needs to be replicated across other histologies? The reason I ask this is, you know, you think about paradigms like, for instance, in the States we're toying between intravenous versus subcutaneous delivery of checkpoint inhibitors, and we have studies focused in specific histologies that might justify use across all histologies. With this particular phenomenon, do you think we need to do dedicated studies in renal cell or in colon cancer and other places where, you know, in selected settings we might use checkpoint inhibitors and then decide whether or not there's this dose equivalence, if you will? Dr. Atul Batra: That's a real tough one, though. But I'm happy to share that there are several ongoing studies within India currently. At our institute, my colleagues are leading studies in lung cancer space, cervical cancer. There was already a publication from Tata Memorial Hospital in head and neck cancers and we see that the signal has been consistent throughout. Regarding renal cancer, there was one study that was presented for sure at ASCO from CMC Vellore, that's again a center in South India. That was in RCC at a much lower dose. And for patients who cannot take the full dose, we actually are offering lower dose nivolumab in such patients and we are seeing responses. I mean, we haven't done those randomized trials again because the numbers are much lower in kidney cancers, we know. We could do this trial in triple-negative ones because we had support and we had numbers to conduct this trial. But I'm sure this should be a class effect. I mean, when we can get tumor-agnostic approvals, then some real-world data has come up in almost all tumors, we have seen that consistent effect across tumors. And as we speak of today, I'm also delighted to share that in India, yesterday, we had the first biosimilar of nivolumab and that's now available at a much, much lower price than the original patent product. There was a long ongoing lawsuit that was there, that's over now, and from yesterday onwards, I'm so happy to share here that we would have the first biosimilar of nivolumab that's available. That's going to bring the cost to almost like one-tenth already. Dr. Monty Pal: Wow. That's huge.  I'm going to be very selfish here for a second and focus on a study that is in the renal cell space that your group has done. You know, when it came out, I was really sort of intrigued by this study as well and it reflects sort of a different capability, I think, of AIIMS New Delhi, and that's in the, what I'm going to call, biomarker space. This, for the audience, was a prospective effort to characterize germline variants in patients with advanced kidney cancer. And it's something that we talk about a lot in the kidney cancer literature, whether or not we're missing a lot of these so-called hereditary patterns of RCC. Can you tell us a little bit about that study too? Dr. Atul Batra: Yeah, so that was led by one of our fellows, Chitrakshi Nagpal, and she's just completed her fellowship. And two years back we published that. So, that was done in almost 160 consecutive patients that we recruited over the span of just one year and we saw, apart from the common known mutations in RCC, that was around 5% or so, but a lot of other mutations were also seen that we don't generally see in kidney cancers and we see in other cancers like BRCA1, BRCA2 and others. We are still, I mean, doing those analyses to see whether we get more things out of there in the somatic: is there a loss of heterozygosity or was it just present and in there? Dr. Monty Pal: I thought it was a terrific study and again, I was just so blown away at the pace. I mean, as I look at 140 patients accrued over a span of one year, this is something that would take us perhaps three times as long at City of Hope, and that's with a very sort of, what I consider to be large and dedicated kidney cancer program. So, it really underscores, I think, the need for collaboration. And ever since I came back from my visit to you at AIIMS Delhi, I think I've just been sort of transformed in the sense of trying to think of better ways for us to collaborate. One tangible thing that I'm going to get cracking on is seeing whether or not perhaps we can form some partnerships through SWOG or what we call the NCTN, the National Clinical Trials Network here within the U.S. Talk to me about collaboration. I mean, you've been really terrific at this. How do you sort of envision collaboration enhancing the global landscape of oncology? Dr. Atul Batra: That's really amazing, Monty. That's what we need. We have the infrastructure, we have the manpower, we have patients. I mean, these are all high-volume centers. Unfortunately, we are a little less in numbers, so we are more clinically occupied as well. So, sometimes it's kind of tougher, but again, when it comes to helping out the patients, global collaboration, we need to kind of take you guys along with us and have our patients finish trials earlier. This is a win-win situation for patients, one, because they also get exposure or an option to participate in the clinical trials, and second, we can answer all these scientific questions that we have at a much faster pace. All those things can be done within a much shorter span of time for sure. We are so happy to hear that, and with open hands we are ready to collaborate for all these efforts. Dr. Monty Pal: That's awesome. You know, I came back thinking, gosh, this would be so ideal for some of these rare subtypes of kidney cancer. Prospective clinical trials that I'm running in that space where really we're threatened with closure all the time. And if we just sort of extended a hand to, you know, our partners in India and other countries, you know, I'm sure we could get this research done in a meaningful way and that's got to be a win for patients. Atul, I had such a terrific time chatting with you today. I'm looking forward to seeing lots more productivity from your group there. By the way, for our viewership here, take a look and see what AIIMS New Delhi is doing under the leadership of Dr. Batra and others. It is just a real powerhouse and I think that after doing so, you'll be enticed to collaborate as well.  I'm hoping this is the first of many times that we have you on the podcast. Thank you so much for joining. Dr. Atul Batra: Thank you so much for having me here, Monty. It was a pleasure as always speaking to you. And thank you again. Dr. Monty Pal: You got it.  Well, and thanks to our listeners. I encourage you to check out Dr. Batra's paper. We'll actually have a link to the study in the transcript of this episode.  Finally, if you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. More on today's speakers:     Dr. Monty Pal   @montypal Dr. Atul Batra @batraatulonc Follow ASCO on social media:          ASCO on X    ASCO on Bluesky         ASCO on Facebook          ASCO on LinkedIn          Disclosures:       Dr. Monty Pal:      Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview     Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical     Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis     Dr. Atul Batra: Stock and Other Ownership Interests: Zydus Pharmaceuticals, Glenmark, Caplin Point Laboratories, Laurus Research Funding: AstraZeneca, Astellas Pharma, Alkem Laboratories

On this month's episode of the Annals of Emergency Medicine podcast, Ryan and Rory discuss TXA in trauma, scores to predict large vessel occlusions in stroke, atrial fibrillation, and much more.

In this episode, I sit down with one of my former mentors and professors, Dr. Alan Penzias, Medical Director at Boston IVF and Associate Professor at Harvard Medical School, to discuss his recent editorial in the Annals of Internal Medicine titled "The Weighty Issue of Obesity and Reproductive Success."  Read the full show notes on Dr. Aimee's website.  We dive deep into how age and weight factor into the fertility equation and why these conversations are so critical for anyone trying to conceive. Dr. Penzias shares his decades of experience helping patients navigate the complex intersection of body mass index, maternal age, and reproductive success, offering practical guidance on when to seek treatment and how to optimize your health before trying to get pregnant. In this episode, we cover: How age remains the strongest predictor of fertility success and why both partners should consider timing The U-shaped curve of BMI and fertility: why both low and high body mass index can impact conception Practical strategies for doctors for discussing weight and fertility with patients in a shame-free, empowering way When to prioritize immediate fertility treatment versus taking time for weight optimization based on age The role of GLP-1 medications (like Tirzepatide) in fertility treatment and safe protocols for use Why unexplained infertility may have hidden explanations related to weight and metabolic health The "do the as if" philosophy: building sustainable health habits one step at a time Resources: Dr. Alan Penzias and Boston IVF: BostonIVF.com Dr. Penzias's editorial: "The Weighty Issue of Obesity and Reproductive Success" - Annals of Internal Medicine https://www.acpjournals.org/doi/10.7326/ANNALS-25-02742  Dr. Penzias's YouTube video: "Evidence-Based Approach to Unexplained Infertility" https://youtu.be/9j4lNvmaXts?si=zmMFZFOno0sWnhcn  American Society for Reproductive Medicine (ASRM) Practice Committee resources on overweight and fertility https://www.asrm.org/ Dr. Stephanie Fein  - Fertility Weight Loss Specialist: https://www.stephaniefeinmd.com/  Hillary Wright, Nutritionist at Boston IVF: https://www.bostonivf.com/physicians/hillary-wright Do you have questions about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, February 9, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!Subscribe to the newsletter to get updates  

🧭 REBEL Rundown 📝Introduction Welcome to this special edition of the REBEL Cast, where we unravel key highlights and educational insights from the IncrEMentuM Conference in Spain. This event is a cornerstone for advancing emergency medicine education, drawing esteemed speakers and participants from around the globe. As emergency medicine gains traction in Spain, this conference has become an essential platform for knowledge exchange and professional growth. Today, host Dr. Mark Ramzy shines a spotlight on two phenomenal educators: Drs. Sara Crager and Ryan Ernst who shared their expertise and experiences at this transformative gathering last spring. Click here for Direct Download of the Podcast. 🤔What's IncrEMentuM? A new conference and a pivotal gathering for emergency medicine professionals worldwide, has become an essential platform for education, collaboration, and advocacy, especially in light of emergency medicine’s recent recognition as a specialty in Spain. The conference is praised for its outstanding production quality, engaging speakers, and its capacity to foster a global community of emergency care professionals. ️What's an Essential Question? Essential questions are open-ended, thought-provoking, and intellectually engaging inquiries that inspire deeper exploration into topics. In the context of medical education, they challenge practitioners to think critically and reflect on their practice deeply. By focusing on essential questions, medical educators aim to inculcate a culture of continuous learning and curiosity, ensuring that medical professionals stay adaptable and insightful in their approach to patient care. 🎮Rapid Sequence (no not the intubating style...)  The Rapid Sequence game is an innovative tool that Sara and Ryan designed to enhance the learning experience for emergency medicine clinicians. It mimics real-life scenarios requiring rapid decision-making in high-pressure situations, such as those faced in emergency medical settings. This clinical case-based game aims to improve cognitive and procedural skills, allowing participants to hone their ability to respond effectively under pressure, thereby enhancing their real-world clinical performance.You can try it out for free on their website here!Their work was featured in the September 2025 edition of Annals of Emergency Medicine as a 2025 ACEP Abstract 🌳The Arboretum Teaching Collective An arboretum is a space that cultivates a wide variety of diverse, unique, and symbiotic growth. Arboretum provides a creative space to decrease barriers, open opportunities, and support the development of extraordinary teachers. The Arboretum Teaching Collective is a non-profit organization dedicated to supporting emergency medicine education in countries where it is a new or evolving specialty.  Their aim to facilitate the development of expert teachers by reducing barriers, providing opportunities, and curating talent.  Their goal is to create a community of educators around the globe who share a vision of bringing excellent, innovative emergency medicine teaching to where it is most needed.  Their approach is driven by curiosity, humility, and sustainability.If you want to learn more and get involved, check out the Arboretum Teaching Collective Website Here ️ See you in Spain! The upcoming conference aims to gather world-class educators once more and promises an enriching experience for all attendees. Drs. Sara Crager and Ryan Ernst, along with many others, will be there at the event. For more information on the IncrEMentuM Conference and to register, visit their website! See you there! Sara Crager, MD Associate Professor, Critical Care and Emergency Medicine UCLA, Los Angeles, CA Ryan Ernst, MD Assistant Professor of Emergency Medicine, Section Chief of Global EM University of Utah, Salt Lake City, UT Mark Ramzy, DO Co-Editor-in-Chief Rutgers Health / RWJBH, Newark, NJ 🔎 Your Deep-Dive Starts Here REBEL CAST – IncrEMentuM26 Speaker Spotlight : Drs. Sara Crager and Ryan Ernst Host Dr. Mark Ramzy shines a spotlight on two phenomenal ... Resuscitation Read More REBEL CAST – IncrEMentuM26 Speaker Spotlight : Drs. Tarlan Hedayati, Jess Mason and Simon Carley Host Dr. Mark Ramzy shines a spotlight on three distinguished ... Resuscitation Read More REBEL CAST – IncrEMentuM26 Speaker Spotlight : George Willis and Mark Ramzy 🧭 REBEL Rundown 📝Introduction In this exciting episode of REBEL ... Endocrine, Metabolic, Fluid, and Electrolytes Read More Incrementum Conference 2026: Revolutionizing Emergency Medicine in Spain In this special episode of Rebel Cast, we spotlight the ... Read More The post REBEL CAST – IncrEMentuM26 Speaker Spotlight : Drs. Sara Crager and Ryan Ernst appeared first on REBEL EM - Emergency Medicine Blog.

Support Us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://libri-vox.org/donateAnnals of a Quiet Neighbourhood (Pt.3)This delightful story begins in a little town called Marshmallows, where a young man, the new vicar, Harry Walton, has just arrived. As he begins his work Harry realizes that everything is not quite 'right' in his little parish and it all seems to center around Oldcastle Hall. As he wins the affection of the people secrets begin to unfold, and Harry Walton attempts to free them from guilt of the past, help them overcome pride and while he is at it, he falls in love with a woman whose past is the most mysterious yet, and whose tyrannical mother is the mistress of Oldcastle Hall.This Is a wonderful, heartwarming romance and a unique mystery, told from the viewpoint of the young vicar. (Summary by Fiddlesticks )The trilogy:⁠Annals of a Quiet Neighbourhood⁠⁠The Seaboard Parish⁠⁠The Vicar's Daughter⁠Genre(s): Romance, Christian FictionLanguage: EnglishKeyword(s): ⁠fiction⁠ (1599), ⁠romance⁠ (1076), ⁠Mystery⁠ (782), ⁠england⁠ (373), ⁠scotland⁠ (88), ⁠country life⁠ (10), ⁠vicar⁠ (2)Support Us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://libri-vox.org/donate

Support Us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://libri-vox.org/donateThis delightful story begins in a little town called Marshmallows, where a young man, the new vicar, Harry Walton, has just arrived. As he begins his work Harry realizes that everything is not quite 'right' in his little parish and it all seems to center around Oldcastle Hall. As he wins the affection of the people secrets begin to unfold, and Harry Walton attempts to free them from guilt of the past, help them overcome pride and while he is at it, he falls in love with a woman whose past is the most mysterious yet, and whose tyrannical mother is the mistress of Oldcastle Hall.This Is a wonderful, heartwarming romance and a unique mystery, told from the viewpoint of the young vicar. (Summary by Fiddlesticks )The trilogy:⁠Annals of a Quiet Neighbourhood⁠⁠The Seaboard Parish⁠⁠The Vicar's Daughter⁠Genre(s): Romance, Christian FictionLanguage: EnglishKeyword(s): ⁠fiction⁠ (1599), ⁠romance⁠ (1076), ⁠Mystery⁠ (782), ⁠england⁠ (373), ⁠scotland⁠ (88), ⁠country life⁠ (10), ⁠vicar⁠ (2)Support Us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://libri-vox.org/donate

Support Us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://libri-vox.org/donateThis delightful story begins in a little town called Marshmallows, where a young man, the new vicar, Harry Walton, has just arrived. As he begins his work Harry realizes that everything is not quite 'right' in his little parish and it all seems to center around Oldcastle Hall. As he wins the affection of the people secrets begin to unfold, and Harry Walton attempts to free them from guilt of the past, help them overcome pride and while he is at it, he falls in love with a woman whose past is the most mysterious yet, and whose tyrannical mother is the mistress of Oldcastle Hall.This Is a wonderful, heartwarming romance and a unique mystery, told from the viewpoint of the young vicar. (Summary by Fiddlesticks )The trilogy:Annals of a Quiet NeighbourhoodThe Seaboard ParishThe Vicar's DaughterGenre(s): Romance, Christian FictionLanguage: EnglishKeyword(s): fiction (1599), romance (1076), Mystery (782), england (373), scotland (88), country life (10), vicar (2)Support Us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://libri-vox.org/donate

D'abord, oui, on le sait désormais, l'allaitement maternel diminue légèrement, mais réellement, le risque de cancer du sein — et cet effet protecteur augmente avec la durée totale d'allaitement au cours de la vie.La preuve la plus souvent citée vient d'une méta-analyse géante publiée dans The Lancet : elle regroupe les données individuelles de 47 études menées dans 30 pays, soit plus de 50 000 femmes atteintes d'un cancer du sein comparées à près de 97 000 femmes non atteintes.Conclusion : le risque relatif de cancer du sein diminue d'environ 4,3% pour chaque 12 mois d'allaitement, et cela en plus de la baisse de risque déjà associée au fait d'avoir eu des enfants. Autrement dit : l'allaitement n'est pas un “bouclier magique”, mais il contribue à réduire le risque, de façon dose-dépendante (plus longtemps = plus protecteur).Pourquoi l'allaitement protège ?Plusieurs mécanismes biologiques sont proposés :pendant l'allaitement, certaines hormones (notamment les œstrogènes) sont plus basses, ce qui réduit la stimulation hormonale du tissu mammaire ;la grossesse et l'allaitement entraînent une maturation des cellules mammaires, qui les rendrait moins susceptibles de devenir cancéreuses ;après l'allaitement, la “remise à zéro” du tissu mammaire (involution) éliminerait aussi certaines cellules potentiellement anormales.Est-ce vrai pour tous les cancers du sein ?L'effet protecteur semble particulièrement marqué pour certains sous-types, notamment les cancers dits hormono-négatifs, comme le triple négatif (plus agressif, plus fréquent chez les femmes jeunes). Une méta-analyse (Annals of Oncology, 2015) retrouve justement une association protectrice plus nette pour ces formes-là. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Smartband-Based Smoking Detection and Real-Time Brief Mindfulness Intervention: Findings from a Feasibility Clinical TrialIn this episode, Dr. Jud examines the groundbreaking results from a feasibility trial exploring the use of smartbands for smoking cessation. This innovative study showcases how wearable technology can detect smoking events in real time and deliver brief mindfulness interventions to address cravings. Dr. Jud discusses the study's design, key findings, and their implications for the future of digital health interventions. Learn how the integration of real-time behavioral data with mindfulness-based techniques holds the potential to transform smoking cessation efforts globally.Reference:Horvath M, Pittman B, O'Malley SS, Grutman A, Khan N, Gueorguieva R, Brewer JA, Garrison KA. Smartband-Based Smoking Detection and Real-Time Brief Mindfulness Intervention: Findings from a Feasibility Clinical Trial. Annals of Medicine. 2024;56(1):2352803. DOI: 10.1080/07853890.2024.2352803Let's connect on Instagram

Episode Summary By Concierge Medicine Today JANUARY 2026 - Concierge medicine and direct primary care didn't just grow — they surged more than 80% in five years. Headlines are spinning this as a threat to access and equity. But is that the full story? In this episode, the Editor-In-Chief of the industry's trade publication, Concierge Medicine Today, author and Host, Michael Tetreault, breaks down the latest national research and explains what's really happening beneath the surface. This isn't about luxury medicine. It's about physician burnout, broken reimbursement models, administrative overload, and doctors quietly redesigning their careers to survive. You'll hear why this shift is less about "escaping responsibility" and more about reclaiming sustainability, why corporate ownership is rising fast, and why concierge medicine didn't create the primary care shortage — it exposed it. If you care about the future of medicine, physician retention, and building healthcare that actually works, this conversation matters.

Die Themen in den Wissensnachrichten: +++ Sterberaten bei Lungenkrebs gehen zurück +++ Zahl möblierter Wohnungen hat sich seit 2012 verdoppelt +++ Pollensaison hat begonnen +++**********Weiterführende Quellen zu dieser Folge:European cancer mortality predictions for the year 2026: the levelling of female lung cancer mortality/ Annals of Oncology, 18.01.2026Mietwohnungssegmente Bedeutung und Auswirkungen auf den Mietwohnungsmärkten/ BBSR, Januar 2026People Underestimate the Acceptability of Canceling Plans with Others/ PsyrArxiv, 08.01.2026Pollenflug-Gefahrenindex/ DWD, 19.01.2026Astronauts as a Human Aging Model: Epigenetic Age Responses to Space Exposure/ Aging Cell, 11.01.2026Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Peter Robbins returns to the show to continue our discussion about Wilhelm Reich. First we discuss some happenings in the UFO world, before delving into some of Reich's theories, Orgone, connections to Eastern philosophy, sex, and even Aleister Crowley. Peter Robbins was first introduced to the books of Wilhelm Reich as a teenager by a college roommate, to whom he remains deeply indebted. In 1976 he met Dr. Elsworth F. Baker, Reich's first assistant for the last eleven years of his life. Soon after this he became a patient of Dr. Baker and entered into almost seven years of medical orgone therapy with the distinguished orgonomist. Robbins went on to enroll in the classes New York University offered in scientific and social orgonomy which was taught by the Reich scholars Professors John Bell and Paul Matthews. They in turn invited him to become a member of their ongoing Seminar in Social and Scientific Orgonomy, patterned after the seminars which Sigmund Freud presided over during the nineteen twenties. Peter spent much of the nineteen eighties involved with this group, presenting a variety of papers to his fellow seminar members under Matthews' and Bell's guidance and leadership. Peter was a volunteer fundraiser for the American College of Orgonomy's (ACO) Building Fund and had two papers on Wilhelm Reich and UFOs published in the Journal of Orgonomy. He was part of a select group of volunteers invited to witness a demonstration of cloudbusting technology and presented on the subject of Reich and UFOs at the ACO's Princeton NJ facility, and at international conferences on the life and work of Reich in New York City, Ashland Oregon, Niece France and Karavomilos Greece. His lectures have been well received at numerous scientific and UFO conferences both here and abroad while his articles on the subject have been published in a variety of print and web publications. Robbins' extensively researched paper, “Politics, Religion and Human Nature: Practical Problems and Roadblocks on the Path Toward Official UFO Acknowledgment” is scheduled to be published in the upcoming issue of Annals of the Institute for Orgonomic Science. Hosted on Acast. See acast.com/privacy for more information.

On the December issue of the Annals of Emergency Medicine podcast, Ryan and Rory discuss ultrasound to assist in the diagnosis of septic arthritis, targeted temperature management in post-cardiac arrest care, the safety of ketamine for procedural sedation, and much more.

On episode #97 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 12/18/25 – 12/31/25. Host: Daniel Griffin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza (OFID) Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1 (Annals of Internal Medicine) Bacterial GeoSentinel Analysis of Travelers' Diarrhea Antimicrobial Resistance Patterns (JAMA Open Network) Rapid direct disk diffusion testing for antibiotic resistance in urinary tract infections: a bacterial concentration-adjusted approach (Microbiology Spectrum) Impact of an Educational Leaflet About Asymptomatic Bacteriuria and Urinary Tract Infection on Antibiotic Preferences Among US Adults ≥65 Years: An Online Randomized Controlled Survey Experiment (OFID) Fungal The Last of US Season 2 (YouTube) Real-world Evaluation of Histoplasmosis Diagnosis and Treatment in Patients From a Michigan Health System (OFID) Parasitic Progress Toward Eradication of Dracunculiasis (Guinea Worm Disease) — Worldwide, January 2024–June 2025 (CDC: MMWR) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Michael Grunwald is an environmental journalist who sees maximizing efficient production as the most important sustianbility strategy. His book, "We Are Eating the Earth," brings fresh attention to an old debate. Episode Links We Are Eating the Earth Grunwald, M. (2024, December 13). Opinion | Sorry, but This Is the Future of Food. The New York Times. https://www.nytimes.com/2024/12/13/opinion/food-agriculture-factory-farms-climate-change.html The Useful Idiot, Land Food Nexus rebuttal to Grunwald's NYT piece The Enduring Fantasy of Feeding the World, Spectre Journal Historians rethink the Green Revolution The Globalization of Wheat: A Critical History of the Green Revolution Max Ajl's A People's Green New Deal On the contribution of yields to hunger abatement:  Smith, L. C., & Haddad, L. (2015). Reducing Child Undernutrition: Past Drivers and Priorities for the Post-MDG Era. World Development, 68, 180–204. https://doi.org/10.1016/j.worlddev.2014.11.014 On the role of intensive agriculture in failing to reduce deforestation: Ceddia, M. G., Bardsley, N. O., Gomez-y-Paloma, S., & Sedlacek, S. (2014). Governance, agricultural intensification, and land sparing in tropical South America. Proceedings of the National Academy of Sciences, 111(20), 7242–7247. https://doi.org/10.1073/pnas.1317967111 Pratzer, M., Fernández-Llamazares, Á., Meyfroidt, P., Krueger, T., Baumann, M., Garnett, S. T., & Kuemmerle, T. (2023). Agricultural intensification, Indigenous stewardship and land sparing in tropical dry forests. Nature Sustainability, 1–12. https://doi.org/10.1038/s41893-023-01073-0 Thaler, G. M. (2017). The Land Sparing Complex: Environmental Governance, Agricultural Intensification, and State Building in the Brazilian Amazon. Annals of the American Association of Geographers, 107(6), 1424–1443. https://doi.org/10.1080/24694452.2017.1309966 Land sparers feel thier oats Thaler, G. M. (2024). Saving a Rainforest and Losing the World: Conservation and displacement in the global tropics. Yale University Press.   The IEA on competing theories of Indirect Land Use Change and biofuels: Towards an improved assessment of indirect land-use change – Evaluating common narratives, approaches, and tools   More Work for Mother: The Ironies Of Household Technology From The Open Hearth To The Microwave | Ruth Cowan Munro, K. (2025). Reconsidering the relationship between home appliance ownership and married women's labor supply: Evidence from Brazil (No. 2509). The Global Alliance for the Future of Food call for investment in food systems transition The World Resources Institute report on Denmark's Green Tripartite Agreement Behind the Danish Green Tripartite – Democracy, Smallholders and the Rights of Rural People Grunwald debates an agroecologist At COP30, Brazilian Meat Giant JBS Recommends Climate Policy    About Landscapes Landscapes is produced by Adam Calo. A complete written transcript of the episode can be found on Adam's newsletter: Land Food Nexus. Send feedback or questions to adamcalo@substack.com or Bluesky Music by Blue Dot Sessions: "Kilkerrin" by Blue Dot Sessions (www.sessions.blue).      

Welcome to Episode 51 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Segment 1 Rodríguez, M. Á., Quintana-Cepedal, M., Cheval, B., Thøgersen-Ntoumani, C., Crespo, I., & Olmedillas, H. (2025, October 7). Effect of exercise snacks on fitness and cardiometabolic health in physically inactive individuals: Systematic review and meta-analysis. British Journal of Sports Medicine. Advance online publication. https://doi.org/10.1136/bjsports-2025-110027 Rodgers, L. (2025, October 17). As pickleball continues to gain players, injuries are increasing. JAMA. https://doi.org/10.1001/jama.2025.18833 Segment 2 Baos, S., Lui, M., Walker-Smith, T., Pufulete, M., Messenger, D., Abbadi, R., Batchelor, T., Casali, G., Edwards, M., Goddard, N., Abu Hilal, M., Alzetani, A., Vaida, M., Martinovsky, P., Saravanan, P., Cook, T., Malhotra, R., Simpson, A., Little, R., Wordsworth, S., Stokes, E., Jiang, J., Reeves, B., Culliford, L., Collett, L., Maishman, R., Chauhan, N., McCullagh, L., McKeon, H., Abbs, S., Lamb, J., Gilbert, A., Hughes, C., Wynick, D., Angelini, G., Grocott, M., Gibbison, B., & Rogers, C. A. (2025). Gabapentin for pain management after major surgery: A placebo-controlled, double-blinded, randomized clinical trial (the GAP Study). Anesthesiology, 143(4), 851-861. https://doi.org/10.1097/ALN.0000000000005655 NEJM Journal Watch. (2024, December 30). Growing evidence of harms associated with gabapentinoid drugs. JWatch. https://www.jwatch.org/na58203/2024/12/30/growing-evidence-harms-associated-with-gabapentinoid-drugs Moeindarbari, S., Beheshtian, N., & Hashemi, S. (2022). Cerebral vein thrombosis in a woman using oral contraceptive pills for a short period of time: A case report. Journal of Medical Case Reports, 16, Article 260. https://doi.org/10.1186/s13256-022-03473-w Peckham, A. M., Evoy, K. E., Ochs, L., & Covvey, J. R. (2018). Gabapentin for off-label use: Evidence-based or cause for concern? Substance Abuse: Research and Treatment, 12, 1178221818801311. https://doi.org/10.1177/1178221818801311 The 2 View: Emergency Medicine PAs & NPs. (2025, January 22). 41 – RCVS and CVT, CPR care science, prehospital tourniquets, blood pressure [Audio podcast episode]. Fireside. https://2view.fireside.fm/41 Strahan, A. E., Rikard, S. M., Schmit, K. M., Zhang, K., Guy, G. P., Jr., & [Additional Authors]. (2025). Trends in dispensed gabapentin prescriptions in the United States, 2010 to 2024. Annals of Internal Medicine. Advance online publication. https://doi.org/10.7326/ANNALS-25-01750 Segment 3 Brown, R. F., Lopez, K., Smith, C. B., & Charles, A. (2025). Diverticulitis: A review. JAMA, 334(13), 1180-1191. https://doi.org/10.1001/jama.2025.10234 Carr, S., & Velasco, A. L. (2024, July 25). Colon diverticulitis. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK541110/ Bob Tubbs on Emergency Radiology: https://youtu.be/Jg1JG67eoJQ Our social media: TikTok: https://www.tiktok.com/@ccmecourses Instagram: https://www.instagram.com/ccmecourses Facebook: https://www.facebook.com/CenterForMedicalEducation LinkedIn: https://www.linkedin.com/in/rickbukata Our podcasts: The 2 View Podcast (Free): Subscribe on Apple Podcasts https://apple.co/3rhVNZw​ Subscribe on Google Podcasts: http://bit.ly/2MrAHcD​ Subscribe On Spotify: http://spoti.fi/3tDM4im Risk Management Monthly Podcast (Paid CME): https://www.ccme.org/riskmgmt ** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. emergencymedicine #cme

Ground-level falls are a leading reason older adults get head CTs in the ER, largely because current rules treat age > 65 as a risk factor by itself. Yet many emergency physicians question whether that's always necessary for well-appearing patients. A new systematic review and meta-analysis in Annals of Emergency Medicine digs deeper, asking: what other factors truly predict intracranial hemorrhage after ground-level falls? Join Dr. Snyder as she explores the findings, limitations, and what they mean for everyday practice.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-462 Overview: In this episode, we examine migraine—a leading cause of disability worldwide that is often underdiagnosed and undertreated in primary care. You'll learn how to distinguish migraine from other headache disorders, identify who is most affected, and explore both acute pharmacologic options and preventive strategies that can reduce attack frequency and improve patients' quality of life. Episode resource links: El Hussein, M. T., & Fraser, L. (2025). Pharmacologic Management of Migraine in Primary Care: Nurse Practitioner Guide. The Journal for Nurse Practitioners, 21(9), 105501. Qaseem, A., Tice, J. A., Etxeandia-Ikobaltzeta, I., Wilt, T. J., Harrod, C. S., Cooney, T. G., ... & Yost, J. (2025). Pharmacologic treatments of acute episodic migraine headache in outpatient settings: a clinical guideline from the American College of Physicians. Annals of internal medicine, 178(4), 571-578. Charles, A. C., Tepper, S. J., & Ailani, J. (2025). State of the art in the management of migraine—A response to the American College of Physicians migraine preventive treatment guideline. Headache: The Journal of Head and Face Pain. Vélez-Jiménez MK, et al. Comprehensive Preventive Treatments for Episodic Migraine: Systematic Review. Front Neurol. 2025 Lanteri-Minet, M., Casarotto, C., Bretin, O., Collin, C., Gugenheim, M., Raclot, V., ... & Lefebvre, H. (2025). Prevalence, characteristics and management of migraine patients with triptan failure in primary care: the EMR France-Mig study. The Journal of Headache and Pain, 26(1), 153. Guest: Mariyan L. Montaque, DNP, FNP-BC   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-462 Overview: In this episode, we examine migraine—a leading cause of disability worldwide that is often underdiagnosed and undertreated in primary care. You'll learn how to distinguish migraine from other headache disorders, identify who is most affected, and explore both acute pharmacologic options and preventive strategies that can reduce attack frequency and improve patients' quality of life. Episode resource links: El Hussein, M. T., & Fraser, L. (2025). Pharmacologic Management of Migraine in Primary Care: Nurse Practitioner Guide. The Journal for Nurse Practitioners, 21(9), 105501. Qaseem, A., Tice, J. A., Etxeandia-Ikobaltzeta, I., Wilt, T. J., Harrod, C. S., Cooney, T. G., ... & Yost, J. (2025). Pharmacologic treatments of acute episodic migraine headache in outpatient settings: a clinical guideline from the American College of Physicians. Annals of internal medicine, 178(4), 571-578. Charles, A. C., Tepper, S. J., & Ailani, J. (2025). State of the art in the management of migraine—A response to the American College of Physicians migraine preventive treatment guideline. Headache: The Journal of Head and Face Pain. Vélez-Jiménez MK, et al. Comprehensive Preventive Treatments for Episodic Migraine: Systematic Review. Front Neurol. 2025 Lanteri-Minet, M., Casarotto, C., Bretin, O., Collin, C., Gugenheim, M., Raclot, V., ... & Lefebvre, H. (2025). Prevalence, characteristics and management of migraine patients with triptan failure in primary care: the EMR France-Mig study. The Journal of Headache and Pain, 26(1), 153. Guest: Mariyan L. Montaque, DNP, FNP-BC   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Peter Robbins returns to the show, and we talk about his return to the UK and Rendlesham, and then get into the life and research of Wilhelm Reich. If you are not familiar with the man, you should be. You will see why on this show. Peter is of course best known for his work on the Rendlesham Forest case, but has an extensive resume dealing with Reich as well. Peter Robbins was first introduced to the books of Wilhelm Reich as a teenager by a college roommate, to whom he remains deeply indebted. In 1976 he met Dr. Elsworth F. Baker, Reich's first assistant for the last eleven years of his life. Soon after this he became a patient of Dr. Baker and entered into almost seven years of medical orgone therapy with the distinguished orgonomist.Robbins went on to enroll in the classes New York University offered in scientific and social orgonomy which was taught by the Reich scholars Professors John Bell and Paul Matthews. They in turn invited him to become a member of their ongoing Seminar in Social and Scientific Orgonomy, patterned after the seminars which Sigmund Freud presided over during the nineteen twenties. Peter spent much of the nineteen eighties involved with this group, presenting a variety of papers to his fellow seminar members under Matthews' and Bell's guidance and leadership.Peter was a volunteer fundraiser for the American College of Orgonomy's (ACO) Building Fund and had two papers on Wilhelm Reich and UFOs published in the Journal of Orgonomy. He was part of a select group of volunteers invited to witness a demonstration of cloudbusting technology and presented on the subject of Reich and UFOs at the ACO's Princeton NJ facility, and at international conferences on the life and work of Reich in New York City, Ashland Oregon, Niece France and Karavomilos Greece. His lectures have been well received at numerous scientific and UFO conferences both here and abroad while his articles on the subject have been published in a variety of print and web publications. Robbins' extensively researched paper, “Politics, Religion and Human Nature: Practical Problems and Roadblocks on the Path Toward Official UFO Acknowledgment” is scheduled to be published in the upcoming issue of Annals of the Institute for Orgonomic Science. Hosted on Acast. See acast.com/privacy for more information.

Support Us: Donation Page – LibriVox Free AudiobooksPublius Cornelius Tacitus (56 - 117)Translated by Alfred John Church (1829 - 1912) and William Jackson Brodribb (1829 - 1905)The Annals was Tacitus' final work, covering the period from the death of Augustus Caesar in the year 14. He wrote at least 16 books, but books 7-10 and parts of books 5, 6, 11 and 16 are missing. Book 6 ends with the death of Tiberius and books 7-12 presumably covered the reigns of Caligula and Claudius. The remaining books cover the reign of Nero, perhaps until his death in June 68 or until the end of that year, to connect with the Histories. The second half of book 16 is missing, ending with the events of the year 66. We do not know whether Tacitus completed the work or whether he finished the other works that he had planned to write; he died before he could complete his planned histories of Nerva and Trajan, and no record survives of the work on Augustus Caesar and the beginnings of the Empire with which he had planned to complete his work as an historian. (Summary from Wikipedia.)Genre(s): Classics (Greek & Latin Antiquity), AntiquityLanguage: EnglishKeyword(s): history (891), rome (75), ancient history (31), Roman history (25), Tacitus (5)Support Us: ⁠Donation Page – LibriVox Free Audiobooks⁠

 In this episode of the podcast, Dr. Zach Portman discusses a new paper addressing the problem of ghost records in bee data. These records often lack physical specimens, creating challenges for verifying data of bee species. Dr. Portman explains the process and complications behind collecting and verifying bee data, emphasizing the importance of preserving specimens. The conversation also delves into the implications of ghost records for conservation efforts and taxonomy, proposing that funding agencies should require proper storage plans for collected specimens. Links: Portman, Z.M., Bruninga-Socolar, B., Chase, M.H., Harrison, T., Arduser, M., Tepedino, V.J. and Cariveau, D.P., 2025. Big data, changing taxonomy, and ghost records: permanent preservation of collected specimens is essential for insect monitoring. Annals of the Entomological Society of America, 118(4), pp.331-345: https://academic.oup.com/aesa/article/118/4/331/8197915 https://www.zportman.com

Each year, the Ig Nobel Prizes recognize scientific research that first makes you laugh, then makes you think. For instance, researchers who investigated the pizza preferences of lizards on the island of Togo. Or a man who kept track of his fingernail growth for 35 years.As is Thanksgiving tradition, we're sharing highlights from this year's Ig Nobels on Science Friday. Annals of Improbable Research editor Marc Abrahams acts as master of ceremonies for the 35th First Annual Ig Nobel Prizes, which include 10 awards, several 24-second scientific lectures, and a mini-opera about indigestion.Guest: Marc Abrahams is the editor and co-founder of Annals of Improbable Research and the founder and master of ceremonies for the Ig Nobel Prize Ceremony in Cambridge, Massachusetts.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Recurrent pregnancy loss (RPL) affects approximately 5% of couples and is an emotional burden on those affected. There is some evidence that vaginal progesterone supplementation may be considered in patients with recurrent pregnancy loss who are experiencing vaginal bleeding during the first trimester. But what about prophylactic low dose aspirin in the first trimester, or preconceptionally, for unexplained RPL? Is that evidence-based? A new publication from the SMFM's journal Pregnancy has examined this. Listen in for details. 1. 22 November 2025: Low-dose aspirin in unexplained recurrent pregnancy loss: A systematic review and meta-analysis (Pregnancy): https://obgyn.onlinelibrary.wiley.com/doi/10.1002/pmf2.700992. American College of Obstetricians and Gynecologists' Committee on Obstetric Practice, T. Flint Porter, Cynthia Gyanff-Bannerman, Tracy Manuck. Low-Dose Aspirin Use During Pregnancy. American College of Obstetricians and Gynecologists (2018)3. Naimi AI, Perkins NJ, Sjaarda LA, et al. The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin-Detected Pregnancy, Pregnancy Loss, and Live Birth : Per Protocol Analysis of a Randomized Trial. Annals of Internal Medicine. 2021;174(5):595-601. doi:10.7326/M20-0469.4. Lee EE, Jun JK, Lee EB.Management of Women With Antiphospholipid Antibodies or Antiphospholipid Syndrome During Pregnancy. Journal of Korean Medical Science. 2021;36(4):e24. doi:10.3346/jkms.2021.36.e24.5. de Assis V, Giugni CS, Ros ST. Evaluation of Recurrent Pregnancy Loss. Obstet Gynecol. 2024 May 1;143(5):645-659. doi: 10.1097/AOG.0000000000005498. Epub 2024 Jan 4. PMID: 38176012.

From 18th century London to the promise of a global cure: the 200-year history of Parkinson's disease. To mark the release of our 'Ask the MD' conversation with The Michael J. Fox Foundation for Parkinson's Research, and to welcome a new influx of listeners, we're sharing one of our very first episodes, first aired in August 2024. Watch our full 'Ask the MD' interview, focused on lifestyle strategies for boosting brain health, on the foundation's website: https://www.michaeljfox.org/news/lifestyle-strategies-boost-brain-health-ask-md-video  Parkinson's, a neurodegenerative disorder most commonly characterized by tremors and other motor symptoms, is so complex, many medical professionals are starting to classify it as a group of diseases, rather than a single disease. In this episode, we explain those complexities, including: • The motor symptoms (e.g. cogwheel rigidity, bradykinesia) and non-motor symptoms (e.g. depression, sleep disorders) • How the industrial revolution may have brought about environmental factors which contribute to Parkinson's • The differences and similarities between Parkinson's and other neurodegenerative diseases, like Alzheimer's • How Parkinson's manifests in our brains • Why one nurse was able to detect Parkinson's through smell • The neurogenetics of Parkinson's, and the ethical quandaries of evolving genetic technology • Why lifestyle — nutrition, exercise, etc. — is so key to preventing and managing Parkinson's Joining us for this extensive conversation are three incredible guests: • Dr. Rachel Dolhun, Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research • Dr. Michael Okun, evolutionary biologist, movement disorders specialist, and Director of the Norman Fixel Institute for Neurological Diseases • Dr. Matthew Farrer, neurogenetics expert and Professor Of Neurology at the University of Florida 'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/  'Your Brain On... Parkinson's' • SEASON 6 • EPISODE 4 (SEASON 3 REUPLOAD) ————— LINKS Dr. Rachel Dolhun: At the Michael J. Fox Foundation: https://www.michaeljfox.org/bio/rachel-dolhun-md-dipablm  'Ask the MD' series: https://www.michaeljfox.org/ask-md  The Michael J. Fox Foundation on YouTube: https://www.youtube.com/@michaeljfoxfoundation/videos  Dr. Michael Okun: At the University of Florida: https://neurology.ufl.edu/profile/okun-michael/  The book 'Ending Parkinson's Disease': https://endingpd.org/  The Norman Fixel Institute: https://fixel.ufhealth.org/ Dr. Matthew Farrer: At the University of Florida: https://neurology.ufl.edu/profile/farrer-matthew/ ————— References: Bloem, B. R., Okun, M. S., & Klein, C. (2021). Parkinson's disease. The Lancet, 397(10291), 2284-2303. Morris, H. R., Spillantini, M. G., Sue, C. M., & Williams-Gray, C. H. (2024). The pathogenesis of Parkinson's disease. The Lancet, 403(10423), 293-304. Dorsey, E., Sherer, T., Okun, M. S., & Bloem, B. R. (2018). The emerging evidence of the Parkinson pandemic. Journal of Parkinson's disease, 8(s1), S3-S8. Dorsey, E. R., Okun, M. S., & Tanner, C. M. (2021). Bad Air and Parkinson Disease—The Fog May Be Lifting. JAMA neurology, 78(7), 793-795. Tsalenchuk, M., Gentleman, S. M., & Marzi, S. J. (2023). Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease. npj Parkinson's Disease, 9(1), 123. Reynoso, A., Torricelli, R., Jacobs, B. M., Shi, J., Aslibekyan, S., Norcliffe‐Kaufmann, L., ... & Heilbron, K. (2024). Gene–Environment Interactions for Parkinson's Disease. Annals of Neurology, 95(4), 677-687. Golsorkhi, M., Sherzai, A., & Dashtipour, K. The Influence of Lifestyle on Parkinson's Disease Management. In Lifestyle Medicine, Fourth Edition (pp. 919-924). CRC Press. Sherzai, A. Z., Tagliati, M., Park, K., Pezeshkian, S., & Sherzai, D. (2016). Micronutrients and risk of Parkinson's disease: a systematic review. Gerontology and geriatric medicine, 2, 2333721416644286. ————— FOLLOW US  Join NEURO  Instagram: @thebraindocs Website: TheBrainDocs.com More info and episodes: TheBrainDocs.com/Podcast

In his weekly clinical update, Dr. Griffin and Vincent Racaniello are dismayed by the changes on CDC vaccine website positively stating the link between autism and vaccination, the finding of wild type poliovirus 1 in Germany, Marburg virus in Ethiopia, decimation of the elephant breeding colony by H5N1 and the first human case of H5N5 influenza virus infection before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, antibody escape by seasonal flu viruses, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, if resistance exercise aids in recovery from long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Autism and Vaccines (CDC: Vaccine Safety) A new road to eradication- WPV 1 in Germany from Afghanistan (Reuters) Ethiopia confirms first outbreak of Marburg virus disease (WHO: Ethiopia) Highly Pathogenic Avian Influenza Viruses (HPAIV) Associated with Major Southern Elephant Seal Decline at South Georgia (Communications Biology) Avian flu has decimated world's largest breeding colony of southern elephant seals (CIDRAP) Washington resident is infected with a different type of bird flu (AP News) Pelagic Seabirds (OceanAminals) That sounds far away: Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals (Cell Reports) Regional voices, different choices: Parents' and caregivers' HPV vaccine attitudes in the northeast and Southeast United States (Vaccine) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: cliff notes (CDC FluView) ACIP Recommendations Summary (CDC: Influenza) Emergence of seasonal influenza A(H3N2) variants with immune escape potential warrants enhanced molecular and epidemiological surveillance for the 2025–2026 season (University of Toronto Press) Types of Influenza Viruses (CDC: Influenza (flu)) With an absent CDC and mismatched 'subclade K' flu strain, experts face upcoming season with uncertainty (CIDRAP) Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Long-term impact of nirsevimab on prevention of respiratory syncytial virus infection using a real-word global database (Journal of Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Estimating Risk of Guillain-Barré Syndrome in US Medicare-Enrolled Older Adults Following Medically Attended Respiratory Syncytial Virus Disease (CID) FDA Requires Guillain-Barré Syndrome (GBS) Warning in the Prescribing Information for RSV Vaccines Abrysvo and Arexvy: FDA Safety Communication (FDA) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) COVID-19 vaccination is associated with reduced complications in pediatric patients with atopic dermatitis (Annals of Allergy, Asthma and Immunology) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) Risk mitigation of shared room ventilation and filtration on SARS-CoV-2 transmission: a multicenter test-negative study (Infection Control and Hospital Epidemiology) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Resistance Exercise Therapy After COVID-19 Infection(JAMA Open Network) Reaching out to US house representative Letters read on TWiV 1272 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.

"Anything beats writing. Writing is tough," says John McPhee, staff writer for The New Yorker and author of more than thirty books of nonfiction.Hey CNFers, this is Episode 500 of The Creative Nonfiction Podcast, the show where I speak to tellers of true tales about the true tales they tell. There are kilometer stones like 100, 200, 300, and 400, but this one, this is a milestone and it features the writer and journalist who made me want to write narrative nonfiction in the first place: John McPhee.John is a titan, a soft-spoken titan. He is the author of more than 30 books, including A Sense of Where You Are, Levels of the Game, his Pulitzer Prize-winning Annals of the Former World, and the book that made me want to write nonfiction: The Survival of the Bark Canoe. John is 94 years young, still lives in Princeton where he has taught an exclusive masterclass on factual storytelling, a class taken by the likes of David Remnick and the late Grant Wahl, I believe, among countless people who have gone on to write and report with distinction.He's been a staff writer for The New Yorker since the 1960s when William Shawn was the editor. Not long thereafter, he was offered a job to teach at his alma mater Princeton University and he famously edited students' submissions not unlike how Shawn edited him at The New Yorker. He's written about such wide ranging topics from basketball, to tennis, to bark canoes, to Alaska, to lacrosse, to oranges, to myriad topics in geology.John is synonymous with thinking through structure and coming up with unique structures for most of his stories, each one something of a fingerprint: no two are alike and the facts borne out from this intensive, slow reporting dictate the shape of the story he has locked into.His work is methodical and patient. He hangs out. He fills notebook after notebook, rarely uses a recorder, maybe only if there's someone speaking in such technical jargon that there's no way to keep pace. His career has been this wonderful balance of give and take: teach for most of the year and not write; then write and not teach. John is unassuming and gentle and an example of how you can do this work without bombast or pyro and still be riveting and sometimes downright hilarious.So we talk about: The influence of his high school English teacher Olive McKee Living room fighters Writing on spec The notebooks he's used for decades How a lack of confidences is an asset What a good editor does Writing as teaching How having a plan frees you to write The panic of having not written leads to productivity And how proud of his daughters he isParting shot on what it all means at 500 and maybe where I see the show going for the next 500.Order The Front RunnerNewsletter: Rage Against the AlgorithmWelcome to Pitch ClubShow notes: brendanomeara.com

Estudio de Jarvis et al. (2025) Estudio con 12,713 pacientes fuera del hospital (excluyendo paros cardíacos). Cuatro grupos de manejo de vía aérea: RSI: 51.2% Sin medicamentos: 29.6% Solo sedación: 17.9% Solo paralíticos: 1.3% Resultado clave: RSI = mayor éxito al primer intento. OR ajustada RSI: 2.23 vs. sin medicamentos. RSI también superior a solo sedación: OR 2.14 RSI > solo paralítico: ligera diferencia (pero relevante clínicamente) ¿Qué es RSI y por qué importa? Proceso farmacológico controlado: sedante + paralítico. Ventajas: Minimiza reflejos de protección. Mejora la visualización glótica. Facilita una intubación más segura. RSI bien ejecutada reduce riesgos: hipoxia, aspiración, trauma laríngeo. Checklist MSMAID – Preparación Crítica Machine, Suction, Monitors, Airway, IV/IO, Drugs. Previene errores. Parte esencial del curso Advanced Airway Management de ECCtrainings. Éxito al Primer Intento = Indicador de Calidad Cada intento adicional → aumento de complicaciones. RSI reduce intentos → mejora seguridad del paciente. Esto valida incluir RSI como pilar de protocolos de manejo avanzado. Relación con las guías AHA 2025 AHA enfatiza mínima interrupción, máximo éxito en intubación. RSI apoya este objetivo. Guías aplicadas en nuestro currículo del curso Advanced Airway Management. RSI en Ambientes Tácticos y de Conflicto Contextos como TEMS, MCI o conflictos armados. RSI como herramienta clave para control rápido de vía aérea. Capacitación: Técnica y Táctica No es solo meter un tubo. Es dominio del protocolo, juicio clínico y manejo de equipo. Cursos ECCtrainings: simulación, casos reales, entrenamiento con maniquíes de alta fidelidad. Llamado a la acción Si quieres mejorar tu dominio de RSI y otras técnicas avanzadas: Inscríbete en nuestro curso Advanced Airway Management. Visita el calendario de cursos en

All over the world, for all of human history – and probably going back to our earliest hominid ancestors – people have found ways to try to keep themselves clean. But how did soap come about? Research: “Soap, N. (1), Etymology.” Oxford English Dictionary, Oxford UP, June 2025, https://doi.org/10.1093/OED/1115187665. American Cleaning Institute. “Soaps & Detergents History.” https://www.cleaninginstitute.org/understanding-products/why-clean/soaps-detergents-history Beckmann, John. “History of Inventions, Discoveries and Origins.” William Johnston, translator. Bosart, L.W. “The Early History of the Soap Industry.” The American Oil Chemists' Society. Journal of Oil & Fat Industries 1924-10: Vol 1 Iss 2. Cassidy, Cody. “Who Discovered Soap? What to Know About the Origins of the Life-Saving Substance.” Time. 5/5/2020. https://time.com/5831828/soap-origins/ Ciftyurek, Muge, and Kasim Ince. "Selahattin Okten Soap Factory in Antakya and an Evaluation on Soap Factory Plan Typology/Antakya'da Bulunan Selahattin Okten Sabunhanesi ve Sabunhane Plan Tipolojisi Uzerine Bir Degerlendirme." Art-Sanat, no. 19, Jan. 2023, pp. 133+. Gale Academic OneFile, dx.doi.org/10.26650/artsanat.2023.19.1106544. Accessed 18 Aug. 2025. Costa, Albert B. “Michel-Eugène Chevreul.” Encyclopedia Britannica. https://www.britannica.com/biography/Michel-Eugene-Chevreul Curtis, Valerie A. “Dirt, disgust and disease: a natural history of hygiene.” Journal of epidemiology and community health vol. 61,8 (2007): 660-4. doi:10.1136/jech.2007.062380 Dijkstra, Albert J. “How Chevreul (1786-1889) based his conclusions on his analytical results.” OCL. Vol. 16, No. 1. January-February 2009. Gibbs, F.W. “The History and Manufacture of Soap.” Annals of Science. 1939. Koeppel, Dan. “The History of Soap.” 4/15/2020. https://www.nytimes.com/wirecutter/blog/history-of-soap/ List, Gary, and Michael Jackson. “Giants of the Past: The Battle Over Hydrogenation (1903-1920).” https://www.ars.usda.gov/research/publications/publication/?seqNo115=210614 Maniatis, George C. “Guild Organized Soap Manufacturing Industry in Constantinople: Tenth-Twelfth Centuries.” Byzantion, 2010, Vol. 80 (2010). https://www.jstor.org/stable/44173107 National Museum of American History. “Bathing (Body Soaps and Cleansers).” https://americanhistory.si.edu/collections/object-groups/health-hygiene-and-beauty/bathing-body-soaps-and-cleansers New Mexico Historic Sites. “Making Soap from the Leaves of the Soaptree Yucca.” https://nmhistoricsites.org/assets/files/selden/Virtual%20Classroom_Soaptree%20Yucca%20Soap%20Making.pdf “The history of soapmaking.” 8/30/2019. https://www.open.edu/openlearn/history-the-arts/history/history-science-technology-and-medicine/history-science/the-history-soapmaking Pliny the Elder. “The Natural History of Pliny. Translated, With Copious Notes and Illustrations.” Vol. 5. John Bostock, translator. https://www.gutenberg.org/files/60688/60688-h/60688-h.htm Pointer, Sally. “An Experimental Exploration of the Earliest Soapmaking.” EXARC Journal. 2024/3. 8/22/2024. https://exarc.net/issue-2024-3/at/experimental-exploration-earliest-soapmaking Ridner, Judith. “The dirty history of soap.” The Conversation. 5/12/2020. https://theconversation.com/the-dirty-history-of-soap-136434 Routh, Hirak Behari et al. “Soaps: From the Phoenicians to the 20th Century - A Historical Review.” Clinics in Dermatology. Vol. No. 3. 1996. Smith, Cyril Stanley, and John G. Hawthorne. “Mappae Clavicula: A Little Key to the World of Medieval Techniques.” Transactions of the American Philosophical Society, vol. 64, no. 4, 1974, pp. 1–128. JSTOR, https://doi.org/10.2307/1006317. Accessed 18 Aug. 2025. Timilsena, Yakindra Prasad et al. “Perspectives on Saponins: Food Functionality and Applications.” International journal of molecular sciences vol. 24,17 13538. 31 Aug. 2023, doi:10.3390/ijms241713538 “Craftsmanship of Aleppo Ghar soap.” https://ich.unesco.org/en/RL/craftsmanship-of-aleppo-ghar-soap-02132 “Tradition of Nabulsi soap making in Palestine.” https://ich.unesco.org/en/RL/tradition-of-nabulsi-soap-making-in-palestine-02112 “Soaps.” https://www.fs.usda.gov/wildflowers/ethnobotany/soaps.shtml van Dijk, Kees. “Soap is the onset of civilization.” From Cleanliness and Culture. Kees van Dijk and Jean Gelman Taylor, eds. Brill. 2011. https://www.jstor.org/stable/10.1163/j.ctvbnm4n9.4 Wei, Huang. “The Sordid, Sudsy Rise of Soap in China.” Sixth Tone. 8/11/2020. https://www.sixthtone.com/news/1006041 See omnystudio.com/listener for privacy information.