Podcasts about Annals

Mary Mallon became known as Typhoid Mary in the early 20th century. She has often been vilified in in modern references, though her story is actually quite complex. Research: "Mary Mallon." Encyclopedia of World Biography Online, vol. 21, Gale, 2001. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/K1631007781/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=23f34010. Accessed 3 Aug. 2026. Brooks, J. “The sad and tragic life of Typhoid Mary.” CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne vol. 154,6 (1996): 915-6. https://pmc.ncbi.nlm.nih.gov/articles/PMC1487781/ Brooks, Janet. “The Sad and Tragic Life of Typhoid Mary.” Canadian Medical Association Journal. Vol. 154, No. 6. 3/15/1996. Cutter, Laura. “Typhoid Mary/Mary Mallon: An Asymptomatic Carrier of Salmonella typhi.” National Museum of Health and Medicine. 6/18/2020. https://medicalmuseum.health.mil/micrograph/index.cfm/posts/2020/typhoid_mary_mary_mallon_salmonella “Research Starter: Typhoid Mary.” https://www.ebsco.com/research-starters/life-sciences/typhoid-mary Faherty, Anna. “The cook who became a pariah.” Wellcome Collection. 6/29/2017. https://wellcomecollection.org/stories/WsT4Ex8AAHruGfW_ Leavitt, Judith Walzer. “‘Typhoid Mary’ Strikes Back: Bacteriological Theory and Practice in Early Twentieth-Century Public Health.” Isis , Dec., 1992, Vol. 83, No. 4 (Dec., 1992). Via JSTOR. https://www.jstor.org/stable/234261 Leavitt, Judith Walzer. "Typhoid Mary: Captive to the Public Health." Beacon Press. 1997. Mallon, Mary. Letter to Dr. William H. Park. June 1909. Via PBS NOVA. https://www.pbs.org/wgbh/nova/typhoid/letter.html Marineli, Filio et al. “Mary Mallon (1869-1938) and the history of typhoid fever.” Annals of gastroenterology vol. 26,2 (2013): 132-134. https://pmc.ncbi.nlm.nih.gov/articles/PMC3959940/ Mason, W.P. “Typhoid Mary.” Science. Vol. 30, No. 760. 7/23/1909. Via JSTOR. https://www.jstor.org/stable/1635174 Murtagh, Joseh. “David DeKok presents gripping, heartbreaking view into Ithaca’s 1903 typhoid outbreak.” Ithica.com. 4/11/2012. https://www.ithaca.com/visit_ithaca/david-dekok-presents-gripping-heartbreaking-view-into-ithaca-s-1903-typhoid-outbreak/article_943a556c-6b6d-11e0-92b9-001cc4c002e0.html New York Times. “Hospital Epidemic from Typhoid Mary.” 3/28/1915. New York Times. “HOSPITAL EPIDEMIC FROM TYPHOID MARY; Germ Carrier, Cooking Under False Name, Spread Disease in Sloane Institution. CAUGHT HIDING IN QUEENS Blamed for Twenty-five Cases of Fever Among Doctors and Nurses -- Now In Quarantine.” 2/28/1915. https://www.nytimes.com/1915/03/28/archives/hospital-epidemic-from-typhoid-mary-germ-carrier-cooking-under.html?eafs_enabled=false Ogan, ML. “Immunization in a Typhoid Outbreak in the Sloane Hospital for Women.” New York Medical Journal. 3/27/1915. 609-610. Othman, Amani and William W. Darrow. “The Wall, the Ban, and the Objectification of Women.” The International Journal of Social Quality, Winter 2019, Vol. 9, No. 2 (Winter 2019). https://www.jstor.org/stable/10.2307/26948452 Poczai P and Karvalics LZ (2022) The little-known history of cleanliness and the forgotten pioneers of handwashing. Front. Public Health 10:979464. doi: 10.3389/fpubh.2022.979464 Prabhu, Maya. “The tragedy of Typhoid Mary.” Gavi. 6/18/2021. https://www.gavi.org/vaccineswork/tragedy-typhoid-mary Pusey, Allen. “Precedents.” ABA Journal. Vol. 104, No. 3. March 2018. Via JSTOR. https://www.jstor.org/stable/10.2307/26516280 Sawyer, Wilbur. “The Efficiency of Various Anti-Typhoid Vaccines.” Journal of the American Medical Association. Vol. LXV, No. 17. 10/13/2015. Soper, G A. “The Curious Career of Typhoid Mary.” Bulletin of the New York Academy of Medicine vol. 15,10 (1939): 698-712. https://pmc.ncbi.nlm.nih.gov/articles/PMC1911442/ Soper, George A. “The Curious Career of Typhoid Mary.” Read May 10, 1939 before the Section of Historical and Cultural Medicine. Bulletin of the New York Academy of Medicine. Vol. 15, No. 10. October 1939. https://pmc.ncbi.nlm.nih.gov/articles/PMC1911442/ Soper, George A. “Typhoid Mary.” The Military Surgeon. Vol. XLV. No. 1. July 1919. Soper, George. A. “The Work of a Chronic Typhoid Germ Distributor.” Journal of the American Medical Association. Vol. XLVIII. No. 24. 6/15/1907. Teicher, Amir. “Typhoid Mary Was Not a Super-Spreader (and Super-Spreaders Are Not "Typhoid Marys").” American journal of public health vol. 113,12 (2023): 1249-1253. doi:10.2105/AJPH.2023.307434 See omnystudio.com/listener for privacy information.

LISTENER DISCRETION IS ADVISED! References: Alam N, Oskam E, et. al. PHANTASi Trial Investigators and the ORCA (Onderzoeks Consortium Acute Geneeskunde) Research Consortium the Netherlands. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018 Jan;6(1):40-50. Jouffroy, R., Annane, D., et. al. (2026). A 1-hour resuscitation bundle for prehospital management of septic shock. Critical Care Medicine. Knack, S. K. S., Scott, N., Driver, B. E., et al. (2024). Early physician gestalt versus usual screening tools for the prediction of sepsis in critically ill emergency patients. Annals of Emergency Medicine. Kotnarin R, Sirinawee P, Supasaovapak J. Impact of Prehospital Antibiotics on in-Hospital Mortality in Emergency Medical Service Patients with Sepsis. Open Access Emerg Med. 2023 May 26;15:199-206. Poynter, M. J., Farrugia, A., Kelly, E., & Simpson, P. M. (2023). Prehospital administration of antibiotics in addition to usual care versus usual care alone for patients with suspected sepsis – A systematic review. Paramedicine, 21, 52–65. Scales DC, et. al. Prehospital antibiotics and intravenous fluids for patients with sepsis: protocol for a 2×2 factorial randomised controlled trial. BMJ Open. 2025 May 27;15(5):e104257.

Today, we are taking a deep dive into a medical truth thatsounds completely counterintuitive, almost upside down, based on everything you think you know about women's health. But here's the kicker: it's actually nothing new at all. For over two decades, ever since the landmark Women'sHealth Initiative (WHI) study made global headlines back in 2002, the blanket narrative surrounding menopausal hormone therapy has been clear and persistent: hormones equal breast cancer risk. But there is a massive asterisk in thatscience that got completely lost in the media noise. While combination therapy with conjugated equine estrogens paired with medroxyprogesterone acetate (CEE +MPA) did show an increased risk, the story for estrogen-only therapy (mainly CEE) in women wh had a hysterectomy is entirely different. In fact, an overwhelming mountain of growing data shows that estrogen-only therapy is protectiveagainst both breast cancer incidence and breast cancer mortality. In this episode, we're unpacking the latest high-level evidence that cements this crucial distinction. We'll examine the broad statistical landscape, including a comprehensive meta-analysis by Qing et al. (officially set for the December 2026 issue of Annals of Medicine, following its ahead-of-print release in March 2026). Their work breaks down how randomized controlled trial data consistentlypoint to estrogen-only therapy having a protective effect, in stark contrast to combination therapy. We'll also dive into a brand-new Clinical Perspective published in mid-August 2026 in Obstetrics & Gynecology (the Green Journal) by Drs. Andrew Kaunitz and Jason Wright. They call urgent attention to this phenomenon, highlighting RCT meta-analyses that demonstrate a 23% reduction in breast cancer incidence with estrogen alone (RR = 0.77), alongside striking cohort data showing a dramatic risk reduction even in high-risk populations, like carriers of the BRCA mutation.  Listenin for details.1.     Wu Q, Shen L, Hu S, Yang R, Wang Y, Xue D, SunY, Ma H, Dai Z. Relationship between menopausal hormone therapy and incidencerisk of breast cancer: systematic review and meta-analysis. Ann Med. 2026Dec;58(1):2640244. doi: 10.1080/07853890.2026.2640244. Epub 2026 Mar.2.     Kaunitz, Wright. Menopausal Estrogen Therapy andRisk of Breast Cancer. Obstet Gynecol. Aug 20263.     Chlebowski RT, Aragaki AK, Pan K, et al.Randomized Trials of Estrogen-Alone and Breast Cancer Incidence: AMeta-Analysis. Breast Cancer Research and Treatment. 2024. 4.     Writing Group for the Women's Health InitiativeInvestigators. (2002). Risks and benefits of estrogen plus progestin in healthypostmenopausal women: Principal results from the Women's Health Initiativerandomized controlled trial. JAMA, 288(3), 321–333.

In part two of our deep dive into China (and part four of our socialist organization series), we break down how Mao attempted to dialectically sublate a national front and a united front. We explore the structural inclusion of the "patriotic national bourgeoisie" into the block of four classes (symbolized by the stars on the Chinese flag) and contrast it with classical Soviet developmental theory and orthodox Marxism.We also dive into:- The historical debate between Chen Duxiu, Li Dazhao, Lenin, and Trotsky.- Why modern "Hoxhaists" and Left Communists consider New Democracy to be revisionist.- The evolution of class structures under Deng Xiaoping and Jiang Zemin's "Three Represents" doctrine (allowing billionaires into the Party).- The reality of modern China's development: Is it a transitioning socialist project, or an hyper-competent form of state capitalism and developmental liberalism?Don't forget to like, subscribe, and hit the notification bell for Episode 5, where we pivot to National Frontism and National Bolshevism.Journal ArticlesDirlik, A. (1970). The ideological foundations of the Chinese Revolution. Journal of Contemporary History, 5(3), 39–54.Dittmer, L. (1977). Line struggle: Notes on its organizational context and theoretical development. Modern China, 3(3), 303–312.Fogel, J. A. (1980). Ai Siqi, establishment intellectual by Joshua A. Fogel. Modern China, 6(1), 23–47.Hammond, E. R. (1978). Marxism and the mass line [Doctoral dissertation, University of California, Berkeley]. ProQuest Dissertations and Theses Global.Korolev, A. (2017). De-ideologized mass line, regime responsiveness, and state-society relations. China Review, 17(2), 7–36.Lyman, S. V. (1970). The Chinese Communist Party in the United Front, 1937–1945 [Doctoral dissertation, University of California, Berkeley]. ProQuest Dissertations and Theses Global.Mazur, M. G. (1995). The United Front of the 1940s: A social and cultural perspective. Modern China, 21(4), 431–456.Selden, M. (1971). The Yenan Way in revolutionary China. The China Quarterly, (45), 263–294.Steiner, H. A. (1951). Current mass line tactics in Communist China. The Annals of the American Academy of Political and Social Science, 277(1), 422–436.Teiwes, F. C. (1978). The origins of rectification: Inner-party purgation in the 1930s. The China Quarterly, (74), 181–201.Tokuda, N. (1971). The mass line during the Yenan period. The China Quarterly, (47), 1–18.Townsend, J. R. (1967). Political participation in Communist China. University of California Press.Womack, B. (1980). The phase of de-Maoization in China. China Report, 16(1), 7–21.Womack, B. (1991). Mao Zedong and the sinification of Marxism. The China Quarterly, (126), 1–15.Young, G. (1980). On New Democracy and the transition to socialism. Modern China, 6(1), 3–22.Books & Primary SourcesCoble, P. M. (2023). The collapse of Nationalist China: How Chiang Kai-shek lost China's civil war. Cambridge University Press.Elbaum, M. (2018). Revolution in the air: Sixties radicals turn to Lenin, Mao and Che. Verso Books.Hirata, K. (2024). Making Mao's steelworks: Industrial Manchuria and the transnational origins of Chinese socialism. Cambridge University Press.Karl, R. E. (2010). Mao Zedong and China in the twentieth-century world: A concise history. Duke University Press.Li, H. (2024). Fighting on the cultural front: U.S.-China relations in the Cold War. Columbia University Press.Lin, C. (2019). Mass line. In C. Sorace, I. Franceschini, & N. Loubere (Eds.), Afterlives of Chinese Communism: Political concepts from Mao to Xi (p. 122). ANU Press.Lovell, J. (2019). Maoism: A global history. Knopf Doubleday Publishing Group.Lowe, D. M. (1966). The function of "China" in Marx, Lenin, and Mao. University of California Press.Mao, Z. (1940). On New Democracy. Marxists Internet Archive.Mao, Z. (1977). A critique of Soviet economics. Monthly Review Press.Moufawad-Paul, J. (2016). Continuity and rupture: Philosophy in the Maoist terrain. Zero Books.Schram, S. R. (Ed.). (2005). Mao's road to power: Revolutionary writings 1912–1949: Vol. VII. New Democracy, 1939–1941. M.E. Sharpe.Zheng, Q. (Ed.). (2020). An ideological history of the Communist Party of China (Vol. 2) (L. Sun & S. Bryant, Trans.). Royal Collins Publishing Group.Send us Fan Mail Musis by Bitterlake, Used with Permission, all rights to BitterlakeSupport the showCrew:Host: C. Derick VarnIntro and Outro Music by Bitter Lake.Intro Video Design: Jason MylesArt Design: Corn and C. Derick VarnLinks and Social Media:twitter: @varnvlogblue sky: @varnvlog.bsky.socialYou can find the additional streams on YoutubeCurrent Patreon at the Sponsor Tier: Jordan Sheldon, Mark J. Matthews, Lindsay Kimbrough, RedWolf, DRV, Kenneth McKee, JY Chan, Matthew Monahan, Parzival, Adriel Mixon, Buddy Roark, Daniel Petrovic,Julian, Drea, Free Beer 

Do GLP-1 medications improve metabolic health as much as they support weight loss? A new observational study in the Annals of Internal Medicine raises an important question about semaglutide, insulin discontinuation, type 2 diabetes, and what meaningful metabolic improvement may require.In this episode of Metabolic Mind, Dr. Bret Scher breaks down a real-world study of more than 9,000 veterans with type 2 diabetes who were using insulin and then added either a GLP-1 receptor agonist, SGLT2 inhibitor, or DPP4 inhibitor. Despite semaglutide's stronger association with weight loss, the study found similar insulin discontinuation rates across all three groups over three years.Dr. Scher covers:Why weight loss and metabolic health improvements may not always move togetherWhat insulin discontinuation can reveal about insulin resistance and beta cell functionWhy semaglutide did not outperform older diabetes medications in this studyThe limitations of observational research and real-world medication dataHow GLP-1 medications and therapeutic carbohydrate reduction may work through complementary mechanismsWhy combining GLP-1s with therapeutic carbohydrate reduction may be an important area for future research and clinical practiceThis conversation takes a closer look at what metabolic health means, and why the path from weight loss to insulin independence may be more complex than the scale alone can show.

You've probably heard both sides of this argument: that organic and conventional produce are nutritionally identical, and that homegrown vegetables blow store-bought out of the water. Which one is true? In this episode, I dig through the peer-reviewed research on three separate questions: whether organic farming produces more nutritious food, whether soil health itself changes the nutrient content of what we eat, and what happens to those nutrients in the days between harvest and the moment food lands on your plate. I'm treating this as a real meta-analysis, pulling together findings from major systematic reviews, long-term field trials, and postharvest storage studies, and following the data wherever it leads. The answer is more interesting, and more useful for your own garden, than either side of the argument usually admits. By the end, you'll know exactly which parts of the nutrient-density conversation hold up under scrutiny and which parts are oversimplified, plus what it means for the food coming out of your own backyard. Let's dig in! Get your bag of Larry's Coffee and a free gift from their fair-trade partners at https://LarrysCoffee.com/JustGrow Peer-Reviewed Sources Smith-Spangler et al. (2012), Annals of Internal Medicine — Are Organic Foods Safer or Healthier Than Conventional Alternatives?: https://www.acpjournals.org/doi/10.7326/0003-4819-157-5-201209040-00007 Baranski et al. (2014), British Journal of Nutrition — Higher Antioxidant and Lower Cadmium Concentrations in Organically Grown Crops (343-study meta-analysis): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141693/ Worthington (2001), Journal of Alternative and Complementary Medicine — Nutritional Quality of Organic Versus Conventional Fruits, Vegetables, and Grains: https://pubmed.ncbi.nlm.nih.gov/11327522/ Hunter et al. (2011), Critical Reviews in Food Science and Nutrition — Evaluation of the Micronutrient Composition of Plant Foods Produced by Organic and Conventional Methods: https://pubmed.ncbi.nlm.nih.gov/21929333/ Montgomery & Biklé (2021), Frontiers in Sustainable Food Systems — Soil Health and Nutrient Density: Beyond Organic vs. Conventional Farming: https://www.frontiersin.org/journals/sustainable-food-systems/articles/10.3389/fsufs.2021.699147/full Lehmann et al. (2014), Soil Biology and Biochemistry — Arbuscular Mycorrhizal Influence on Zinc Nutrition in Crop Plants: A Meta-Analysis: https://www.sciencedirect.com/science/article/abs/pii/S0038071713004045 Reganold et al. (2010), PLOS ONE — Fruit and Soil Quality of Organic and Conventional Strawberry Agroecosystems: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012346 Helfenstein et al. (2016), PLOS ONE — Organic Wheat Farming Improves Grain Zinc Concentration: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160729 Hepperly, Omondi & Seidel (2018), MOJ Food Processing & Technology — Soil Regeneration Increases Crop Nutrients, Antioxidants and Adaptive Responses (Rodale Institute Farming Systems Trial): https://medcraveonline.com/MOJFPT/soil-regeneration-increases-crop-nutrients-antioxidants-and-adaptive-responses.html Davis, Epp & Riordan (2004), Journal of the American College of Nutrition — Changes in USDA Food Composition Data for 43 Garden Crops, 1950 to 1999: https://pubmed.ncbi.nlm.nih.gov/15637215/ Marles (2017), Journal of Food Composition and Analysis — Mineral Nutrient Composition of Vegetables, Fruits and Grains: The Context of Reports of Apparent Historical Declines: https://www.sciencedirect.com/science/article/pii/S0889157516302113 Favell (1998), Food Chemistry — A Comparison of the Vitamin C Content of Fresh and Frozen Vegetables: https://www.sciencedirect.com/science/article/abs/pii/S0308814697001659 Rickman, Barrett & Bruhn (2007), Journal of the Science of Food and Agriculture — Nutritional Comparison of Fresh, Frozen and Canned Fruits and Vegetables, Part 1: https://scijournals.onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.2825 Li, Pegg, Eitenmiller, Chun & Kerrihard (2017), Journal of Food Composition and Analysis — Selected Nutrient Analyses of Fresh, Fresh-Stored, and Frozen Fruits and Vegetables: https://www.sciencedirect.com/science/article/abs/pii/S0889157517300418 Galani et al. (2017), Antioxidants — Storage of Fruits and Vegetables in Refrigerator Increases Their Phenolic Acids but Decreases the Total Phenolics, Anthocyanins and Vitamin C: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618087/ Jo, Shin & Lee (2003), Journal of Agricultural and Food Chemistry — The Effect of Post-Harvest and Packaging Treatments on Glucoraphanin Concentration in Broccoli: https://pubs.acs.org/doi/10.1021/jf0203592 Just Grow Something: https://justgrowsomething.com Gardening Courses: https://justgrowsomething.com/courses Just Grow Something Merch and Downloads: https://justgrowsomething.com/shop Just Grow Something Gardening Friends Facebook Group: https://www.facebook.com/share/g/18YgHveF5P/ Check out how you can become a patron on Patreon: https://www.patreon.com/JustGrowSomething Feed my coffee habit: https://buymeacoffee.com/justgrowsomething Amazon storefront: https://www.amazon.com/shop/justgrowsomething Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In Acts 11:26 we read that the disciples were called Christians first at Antioch. "Disciple" is the most used word in the New Testament to describe followers of Jesus. It is used 261 times. The word "Christian" is used only 3 times in the New Testament. Brothers and sisters, believers, followers are also used but "disciples" is Jesus' favorite word to describe His followers.   Matthew 29:19-20 - the Great Commission - Jesus says, "Therefore go and make disciples of all nations, baptizing them in the name of the Father and of the Son and of the Holy Spirit, and teaching them to obey everything I have commanded you. And surely I am with you always, to the very end of the age."   The other 2 uses of Christian: Acts 26:28 Then Agrippa said to Paul, "Do you think that in such a short time you can persuade me to be a Christian?" 1 Peter 4:16 However, if you suffer as a Christian, do not be ashamed, but praise God that you bear that name.   The New Testament word appears to be invented by the opposition, a derisive term patterned after the names of Roman political parties; Example those following Herod = Herodians, or followers of Pompe = Pompeians.   Christian = Christ followers. Or "Christ-ers."   Followers of Jesus accepted and reveled in the name.  In the writings of non-Christian people we see them embracing that term. "And the tribe of the Christians so called after him, has still to this day not disappeared." - Josephus, Antiquities, Book 18 (ca. 93A.D.)    Another example from an adamant unbeliever: "Consequently, to get rid of the reports, Nero fastened the guilt and inflicted the most exquisite tortures on a class hated for their abominations, called Christians by the populace. Christus, from whom the name had its origin, suffered the extreme penalty during the reign of Tiberius at the hands of one of our procurators, Pontius Pilat…" Tacitus, The Annals, Book 15 (ca.118 A.D.)   Christian is all about the Messiah, the Christ of God, the Lord Jesus our Savior and the world's Savior.  It's also about our mission to bring others to Christ where there is healing, forgiveness, and hope of eternal life.     We are called to bear His Name with joy, confidence and power!!     Now What? Learn about God at https://www.awakeusnow.com EVERYTHING we offer is FREE.   View live or on demand: https://www.awakeusnow.com/tuesday-bible-class   For the full list of videos in this series, Dig Deeper, https://www.awakeusnow.com/dig-deeper   For more check out our Sunday series, God ACTS! https://www.awakeusnow.com/god-acts-then-now   Join us Sundays  https://www.awakeusnow.com/sunday-service   Or watch from our Youtube channel https://www.youtube.com/@AwakeUsNow/videos     Watch via our app. Text HELLO to 888-364-4483 to download our app.

Welcome to the latest episode (August 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Updates: Hirsh Elhence, Jennifer L. Dodge, Stephen Fuest, et al. National Prevalence of Clinical Obesity by BMI Class: A National Cross-Sectional Study. Ann Intern Med. [Epub 2 June 2026]. doi:10.7326/ANNALS-25-05287 Eva Johnsen, et al. Achieving at Least 15% Weight Loss Within 2 Years of Type 2 Diabetes Diagnosis Is Associated With Lower Risks of Macrovascular and Microvascular Complications: A U.K. Cohort Study. Diabetes Care 20 July 2026; 49 (8): 1480–1489. doi.org/10.2337/dc26-0937 Carel W. le Roux, et al. Survodutide Once Weekly for the Treatment of Adults with Obesity. The New England Journal of Medicine June 2026 DOI: 10.1056/NEJMoa2600751 Yu Wang, Shichao Tang, Xilin Zhou, Ping Zhang. National Trends in Out-of-Pocket Cost for Glucose-Lowering Drugs Among U.S. Adults With Diabetes, 2000–2022. Diabetes Care 20 July 2026; 49 (8): 1414–1419. https://doi.org/10.2337/dc25-2040 Jelle M. Beernink, et al. Effect of Finerenone on Albuminuria in Type 1 Diabetes by Baseline HbA1c Level and Diabetes Duration: An Exploratory Analysis of the FINE-ONE Trial. Diabetes Care 20 July 2026; 49 (8): 1434–1441. https://doi.org/10.2337/dc26-0882 Welch M, Forst T, Jia W et al. Orforglipron compared with dapagliflozin in adults with type 2 diabetes and inadequate glycaemic control with metformin (ACHIEVE-2): a multicentre, randomised, non-inferiority, open-label, phase 3 trial. The Lancet, 2026; 408, 125-140 DOI: 10.1016/S0140-6736(26)00800-7 Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health DOC Updates is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's three science and medical journals—Diabetes, Diabetes Care, and Diabetes, Obesity, and CardioMetabolic CARE. Intended for practicing physicians and health care professionals, DOC Updates discusses how the latest research is relevant in clinical practice. For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, click here.

The 2025 measles outbreak in New Mexico cost that state an estimated $5.4 million. That's according to an analysis in the Annals of Internal Medicine published on Aug. 3.

With increasing efforts to scale into international markets, what can we expect from China's drug development industry? Joining the podcast is Daphne Smyth, head of global regulatory programs at Veristat, who shares her experience at this year's BioChina and what to expect for drug development on a global scale. Smyth explains why North America and Europe have been attractive market destinations for the Chinese market now more than ever, the regulatory reforms, and the potential bumps on the road getting Chinese drugs to foreign markets. Plus, host Deborah Borfitz gives you the latest news on the quantified financial value of risk-based quality management, a shingles vaccine for lowering dementia risk, a Parkinson's disease drug for treating depression, an AI for treating neuroblastoma, a link between hormonal birth control and brain health in older age, and Bayer's first strategic alliance with an academic medical center focused on clinical trials collaboration. Financial value of RBQM Study in Therapeutic Innovation & Regulatory Science News release from CluePoints Shingles vaccine may lower dementia risk Study in Annals of Internal Medicine  News on the Brown University website  Parkinson's drug for treatment-resistant depression Study in Nature Medicine  News on the Lund University website AI for improving neuroblastoma outcomes Research article in APL Quantum  News on the University of Utah website Brain-protecting effect of hormone therapies Study in NeuroImage News on the University of Kansas website  Bayer's alliance with academic medical center News on the University of Colorado Anschutz website Guest Daphne Smyth, head of global regulatory programs for Veristat  Article in Clinical Research News about opportunities in China The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider's look at clinical research today.  

Hosts Pastor Rico Basso and Pastor Lloyd Pulley Question Timestamps: Randy, email (2:56) - What does the Bible say about families serving together at church? Should we serve in the same ministry or different ministries? Joe, email (7:44) - Does my depression mean that I am not saved? Arthur, YouTube (10:08) - Should my friend still leave her boyfriend, even though he only goes to church for her? Sarah, NJ (13:52) - How do I know what voices to listen to when it comes to Bible teaching? Load Hauler, YouTube (17:35) - Where would you say the Book of the Annals is? William, SC (21:02) - If John the Baptist was the last prophet, how do you define or explain the role of a prophet described by Paul, or the modern prophets in prosperity churches? Jennifer, AL (27:58, continued after break at 33:23) - Should my boyfriend work? How do I convince him to help meet our needs? Dawn, NJ (38:34) - How should I handle my husband with his alcoholism and narcissism? Aisha, NJ (44:07) - Are random acts of violence, such as children getting killed, part of God's will? Arthur, YouTube (49:48) - How does the sin of covetousness destroy a person? Sandy, email (53:55) - What should or can I do to be an influence in schools against abortion as a teacher? Ask Your Questions: Call: 888-712-7434 Email: Answers@bbtlive.org

In this new episode of Speaking of SurgOnc, Dr. Rick Greene discusses with Dr. Sara Mansfield the article: "Surgical Management and Outcomes in Pediatric Adrenocortical Carcinoma: A Pediatric Surgical Oncology Research Collaborative Study" from the March 2026 Issue of the Annals of Surgical Oncology.

Circulating tumor DNA (ctDNA), a minimally invasive blood-based biomarker, has emerged as one of the most promising advances in cancer surveillance. Today, we will explore how ctDNA is transforming the management of colorectal cancer and anal squamous cell cancer across the disease continuum—from risk stratification and adjuvant therapy decision-making to surveillance and early detection of recurrence. Through landmark clinical trials, real-world applications, and emerging research, we will examine how ctDNA is helping move cancer care closer to the goal of truly personalized medicine.Hosts: ·       Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center·       Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian·       Dr. Philip Bauer, Assistant Professor of Surgery, Division of Colon and Rectal Surgery, The Ohio State University Wexner Medical Center, Arthur G. James Cancer Hospital·       Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer CenterGuests:Dr. Paul Romessor ·      Director of Colorectal and Anal Cancer, Department of Radiation Oncology·      Associate Attending Radiation OncologistMemorial Sloan Kettering Cancer CenterDr. Jeanne Tie ·      Medical Oncologist | Lower GI Unit ·      Lower GI Research Lead ·      Chair | Lower GI Working Party | GI Cancer TrialsPeter MacCallum Cancer Centre Dr. Takayuki Yoshino·      Professor, Global Center of Research Excellence for Advanced Medicine (G-CORE),Keio University School of Medicine·      Executive Advisor to Hospital East Director·      Director, Department of Global Oncology·      Chief, Department of Gastrointestinal OncologyNational Cancer Center Hospital EastLearning Objectives:·      Describe the biological basis and clinical applications of circulating tumor DNA (ctDNA) as a biomarker of minimal residual disease (MRD) in colorectal cancer.·      Interpret the prognostic significance of postoperative and longitudinal ctDNA testing and its role in predicting recurrence risk across stages of colorectal cancer.·      Evaluate evidence from landmark clinical trials, including DYNAMIC and GALAXY, supporting ctDNA-guided treatment de-escalation and escalation strategies in colorectal cancer.·      Discuss emerging applications of ctDNA monitoring in personalized cancer care, including surveillance, treatment response assessment, and future clinical trial directions. References:·      Ando, K. et al. (2026). Molecular Residual Disease and Recurrence in Rectal Cancer Patients Undergoing Upfront Surgery: A Prospective Cohort Study. Annals of Surgery. https://pubmed.ncbi.nlm.nih.gov/39854721/ (Note: If direct access is limited, the article is available via PMC: PMC12695342)·      Romesser, P. B. et al. (2026). Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma. Nature Communications. https://pubmed.ncbi.nlm.nih.gov/38347209/·      Tie, J. et al. (2025). Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial. Nature Medicine. https://pubmed.ncbi.nlm.nih.gov/39943485/·      Tie, J. et al. (2025). Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial. Nature Medicine. https://pubmed.ncbi.nlm.nih.gov/39974258/Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

What really helps you live a long, healthy life? Can healthy ageing be as simple as a few everyday habits? In this episode, Dr. Ezekiel Emanuel, world-leading oncologist, bioethicist and World Health Organization adviser, shares six rules from his book Eat Your Ice Cream that may help lower your risk of dementia, heart disease, cancer and early death.  Ezekiel explores the science of healthy ageing, longevity and disease prevention, and explains why many wellness trends distract us from what matters most. By the end of the episode, you'll have six practical habits that have the biggest impact on living well for longer. From building stronger relationships and staying mentally active to improving your diet, exercise and sleep, Ezekiel offers a simple framework designed to support health over decades, not weeks. If you want to live a longer, healthier life, are you focusing on the habits that matter most? 

Do you have trouble sleeping? An occasional late night or early morning is probably not dangerous, but too many people get too little sleep on a regular basis. How does that affect their health? Even more importantly, what can they do to change the situation? You'll want to listen to find out if you need a sleep reset. At The People's Pharmacy, we strive to bring you up to date, rigorously researched insights and conversations about health, medicine, wellness and health policies and health systems. While these conversations intend to offer insight and perspective, the content is provided solely for informational and educational purposes. Please consult your healthcare provider before making any changes to your medical care or treatment. How You Can Listen You could listen through your local public radio station or get the live stream at 7 am EST on Saturday, July 18, 2026, through your computer or smart phone (wunc.org). Here is a link so you can find which stations carry our broadcast. If you can't listen to the broadcast, you may wish to hear the podcast later. You can subscribe through your favorite podcast provider, download the mp3 using the link at the bottom of the page, or listen to the stream on this post starting on July 20, 2026. The podcast will be available on Monday (July 20, 2026) Do You Need a Sleep Reset? Why is sleep so important for good health? Our guest is a sleep medicine specialist who uses a metaphor of Disneyland. Crucial maintenance on the theme park happens at night, when there are no visitors. Streets are cleaned, flower beds are weeded, and rides are inspected and, if needed, repaired. None of that can happen while the park is open for business. Our bodies and brains also need time for maintenance and repair, and some of that happens while we are sleeping. When we don't get the rest we need, we may find ourselves at increased risk for diabetes, cardiovascular problems, cancer, cognitive challenges and even premature death. Unfortunately, anxiety about not sleeping can keep people awake all on its own. How can people break that cycle? We'll also discuss ways that people can get help avoiding screens at night. That is an important part of a sleep reset. Blue light from the screen signals the brain to be alert instead of relax. Scrolling social media can often be emotionally upsetting, which also makes it more difficult to fall asleep. Is Your Diet Keeping You Awake? Most of us recognize that a big midnight snack, á la Dagwood Bumstead of the Blondie comic, is probably not conducive to sleeping well. How does nighttime eating affect our circadian rhythm? Are there diets that we should avoid because of their impact on sleep? Dr. Seheult describes a study in which volunteers had their sleep stages monitored closely during the time they were consuming different diets (Obesity, July 2023). When they followed a high-fat, high-sugar diet, it disturbed the pattern of their brain waves during what should have been restorative sleep. How Do Sleep Problems Affect Eating Habits? A lot of us are aware that when we are sleep deprived, we are more inclined to become hangry and we may be less discerning about what we eat. A recent study shows that the sleep deprivation can have an effect even if it is fairly mild and short-term. Scientists recruited people who normally sleep seven to eight hours a night and asked them to stay up an extra hour and a half (Annals of Internal Medicine, July 7, 2026).  During the six weeks of that part of the experiment, people were less active during the day. They also ate more, so they gained about a pound, on average, during those six weeks. Presumably, disrupting sleep for a longer period of time would result in greater weight gain and metabolic disruption. Would a Ketogenic Diet Help with a Sleep Reset? A ketogenic diet, in which the body relies on ketones rather than glucose for energy production, may be helpful. In particular, fasting overnight for at least 14 hours helps the body do what it must during sleep time. To figure out when you should stop eating, identify when you usually start to feel sleepy. That should be your bedtime. Having your last meal of the day about three hours before that will generally offer enough time for digestion so that you don't experience reflux in the middle of the night. Morning Light and Afternoon Naps Your sleep reset may depend on getting your own circadian rhythm to synchronize with the rest of the world. That is where early exposure to morning light comes in. It's beginning to feel a bit like The People's Pharmacy is on repeat: get morning light exposure! It sets your system up for feeling awake and alert during the day and starting to feel sleepy as the light fades in the evening. Obviously, this is most helpful for people who work during daylight hours. Those working overnight shifts would have to organize their days differently. People who have trouble falling asleep may be tempted to take a nap in the afternoon to make up for the lost sleep. That could be a mistake, as it relieves the sleep pressure that helps people fall asleep without trying. Learning to Fall Asleep If you interact with parents of very young children, you may have heard of sleep training. People have strong feelings about this, both pro and con. Adults rarely need sleep training, though. What we are more likely to need is “not-sleeping un-training.” Too many people approach the bedroom as though it were a stage, and sleep is the performance. No wonder they may develop some performance anxiety about sleeping! Other individuals have learned to associate the bedroom with tossing, turning and watching the clock. Consequently, their bodies tense up instead of relaxing when they get between the sheets. There is no easy quick fix for this problem, but cognitive behavior therapy for insomnia has been proven effective for most people. How About PM Pain Relievers? Even though there isn't an easy fix for sleep troubles, many people want one. They reach for the PM pain reliever and hope it will offer them a good night's sleep without a prescription. The “PM” part of that pain reliever is an old-fashioned antihistamine called diphenhydramine. You might be more familiar with its brand name: Benadryl. You'll also find it in Tylenol PM, Advil PM and all the other PM meds because it tends to make people feel drowsy. What's wrong with that? To start with, it isn't clear that it remains effective after a week or two. In addition, people with restless leg syndrome often find that it makes their condition worse. Other folks report that diphenhydramine can result in an unpleasant “hangover” the next day, in which they feel drowsy though not asleep for a good part of their waking hours. What Wakes You Up at Night? If your sleep problem is waking in the wee hours and having trouble getting back to sleep, you should consider the possibility that you have sleep apnea. The REM sleep of those early morning hours is not as deep as some other sleep stages. Consequently, an alarm signal from your brain saying you haven't taken a breath for 20 or 30 seconds may be more likely to wake you. Sleep apnea may be treated by providing air so that the pressure props the collapsing airway open. We discuss this in greater detail along with a new alternative to a CPAP machine in the podcast for this week. This Week’s Guest Dr. Roger Seheult is an Associate Clinical Professor at the University of California, Riverside School of Medicine. He is also an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple board-certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine, and Sleep Medicine through the American Board of Internal Medicine. His current practice is in Beaumont, California. He is a critical care physician, pulmonologist, and sleep physician at Optum California. Dr. Seheult lectures routinely across the country at conferences and for medical, PA, and RT societies. He is the director of a sleep lab and the Medical Director for the Crafton Hills College Respiratory Care Program. He is co-founder and presenter for MedCram.com, a site that offers concise and easy-to-follow medical videos on a range of topics. Roger Seheult, MD, MedCram, Loma Linda, UC-Riverside Listen to the Podcast The podcast of this program will be available Monday, July 20, 2026, after broadcast on July 18. You can stream the show from this site and download the podcast for free. Download the mp3, or listen to the podcast on Apple Podcasts or Spotify.

In this episode of VarnVlog, we are joined by Brandon Lightly to discuss the complex and often misunderstood history of Maoism. We dive deep into the theoretical underpinnings of the "mass line" and "new democracy," exploring how these concepts served as an internal critique of Marxism and a departure from Soviet-style bureaucracy.Key Topics Covered:Defining the Mass Line: Is it just populism, or a sophisticated leadership feedback loop?The Historical Origins: From the Hunan Report to the Long March and the second United Front.Theoretical Innovations: Mao's 1961 critique of Joseph Stalin and the rejection of the "Great Man" theory of history.Fragmentation: Why there are so many different Maoist tendencies (MLM, MIM, Third Worldism).Praxis: The rectification movement and the relationship between urban intellectuals and the rural peasantry.Journal ArticlesDirlik, A. (1970). The ideological foundations of the Chinese Revolution. Journal of Contemporary History, 5(3), 39–54.Dittmer, L. (1977). Line struggle: Notes on its organizational context and theoretical development. Modern China, 3(3), 303–312.Fogel, J. A. (1980). Ai Siqi, establishment intellectual by Joshua A. Fogel. Modern China, 6(1), 23–47.Hammond, E. R. (1978). Marxism and the mass line [Doctoral dissertation, University of California, Berkeley]. ProQuest Dissertations and Theses Global.Korolev, A. (2017). De-ideologized mass line, regime responsiveness, and state-society relations. China Review, 17(2), 7–36.Lyman, S. V. (1970). The Chinese Communist Party in the United Front, 1937–1945 [Doctoral dissertation, University of California, Berkeley]. ProQuest Dissertations and Theses Global.Mazur, M. G. (1995). The United Front of the 1940s: A social and cultural perspective. Modern China, 21(4), 431–456.Selden, M. (1971). The Yenan Way in revolutionary China. The China Quarterly, (45), 263–294.Steiner, H. A. (1951). Current mass line tactics in Communist China. The Annals of the American Academy of Political and Social Science, 277(1), 422–436.Teiwes, F. C. (1978). The origins of rectification: Inner-party purgation in the 1930s. The China Quarterly, (74), 181–201.Tokuda, N. (1971). The mass line during the Yenan period. The China Quarterly, (47), 1–18.Townsend, J. R. (1967). Political participation in Communist China. University of California Press.Womack, B. (1980). The phase of de-Maoization in China. China Report, 16(1), 7–21.Womack, B. (1991). Mao Zedong and the sinification of Marxism. The China Quarterly, (126), 1–15.Young, G. (1980). On New Democracy and the transition to socialism. Modern China, 6(1), 3–22.Books & Primary SourcesCoble, P. M. (2023). The collapse of Nationalist China: How Chiang Kai-shek lost China's civil war. Cambridge University Press.Elbaum, M. (2018). Revolution in the air: Sixties radicals turn to Lenin, Mao and Che. Verso Books.Hirata, K. (2024). Making Mao's steelworks: Industrial Manchuria and the transnational origins of Chinese socialism. Cambridge University Press.Karl, R. E. (2010). Mao Zedong and China in the twentieth-century world: A concise history. Duke University Press.Li, H. (2024). Fighting on the cultural front: U.S.-China relations in the Cold War. Columbia University Press.Lin, C. (2019). Mass line. In C. Sorace, I. Franceschini, & N. Loubere (Eds.), Afterlives of Chinese Communism: Political concepts from Mao to Xi (p. 122). ANU Press.Lovell, J. (2019). Maoism: A global history. Knopf Doubleday Publishing Group.Lowe, D. M. (1966). The function of "China" in Marx, Lenin, and Mao. University of California Press.Mao, Z. (1940). On New Democracy. Marxists Internet Archive.Mao, Z. (1977). A critique of Soviet economics. Monthly Review Press.Moufawad-Paul, J. (2016). Continuity and rupture: Philosophy in the Maoist terrain. Zero Books.Schram, S. R. (Ed.). (2005). Mao's road to power: Revolutionary writings 1912–1949: Vol. VII. New Democracy, 1939–1941. M.E. Sharpe.Zheng, Q. (Ed.). (2020). An ideological history of the Communist Party of China (Vol. 2) (L. Sun & S. Bryant, Trans.). Royal Collins Publishing Group.Send us Fan Mail Musis by Bitterlake, Used with Permission, all rights to BitterlakeSupport the showCrew:Host: C. Derick VarnIntro and Outro Music by Bitter Lake.Intro Video Design: Jason MylesArt Design: Corn and C. Derick VarnLinks and Social Media:twitter: @varnvlogblue sky: @varnvlog.bsky.socialYou can find the additional streams on YoutubeCurrent Patreon at the Sponsor Tier: Jordan Sheldon, Mark J. Matthews, Lindsay Kimbrough, RedWolf, DRV, Kenneth McKee, JY Chan, Matthew Monahan, Parzival, Adriel Mixon, Buddy Roark, Daniel Petrovic,Julian, Drea, Free Beer 

Cash-Pay Generic Drugs Are a Functioning Market in Healthcare, and Policymakers Could Break It. Episode 520. Cash-pay generic drugs are one of the few corners of US healthcare where a real, functioning market already exists — which is why Stacey Richter argues policymakers need to tread carefully when trying to "fix" drug affordability. In this solo episode, Stacey explains why cash generic prices can run as low as $1 a prescription, then plays clips from four past guests — Ge Bai, PhD, CPA; Bryce Platt, PharmD; Benjamin Jolley, PharmD; and Luke Slindee, PharmD — showing how inserting a PBM extracts $41 out of every $100 spent, leaving patients paying more for the "privilege" of using their insurance. WHAT YOU'LL LEARN ✅ Why cash-pay generic drugs are one of the few genuinely functioning markets left in US healthcare, with multisource manufacturer competition keeping prices as low as $1 to $18 per prescription ✅ Why using insurance/PBM coverage makes the 20 most prescribed generics more expensive 43% of the time overall, and up to 79% of the time in the deductible phase, per Ge Bai, PhD, CPA's research in Annals of Internal Medicine ✅ How PBMs extract $41 out of every $100 spent on generic drugs that cost roughly 47 cents to manufacture, largely through the administrative overhead of risk pooling ✅ How Most Favored Nation "lesser of" clauses in PBM-pharmacy contracts punish pharmacies for lowering their cash prices, and why Luke Slindee, PharmD, argues removing that single clause could unlock a more robust cash-pay market without pulling generics from insurance entirely ✅ Why generic drug adoption has slowed from about one month to six months to reach peak uptake, which Bryce Platt, PharmD, ties to PBM formulary control rather than reduced competition or prescriber resistance ✅ Four policy ideas Stacey floats for keeping generics affordable without wrecking the underlying market: eliminating MFN clauses, funded wallets or prepaid cards, pre-funded cash-pay pharmacy relationships, and removing generics from PBM adjudication entirely WHY THIS MATTERS Generic drugs are one of the only truly functioning markets left in US healthcare, and cash prices are already low because of it. But policymakers trying to make medications more affordable often reach for the same lever — routing everything through insurance/PBM adjudication — which the data shows frequently raises what patients pay while handing PBMs a 41-cent cut of every dollar spent. As Stacey puts it, "you have to be really careful what levers you push because you can't see what they're attached to," and the wrong fix could break the one part of healthcare that's actually working. MENTIONED IN THIS EPISODE EP444 with Ann Kempski: Apple Podcasts | Spotify | Other Apps LinkedIn Post by Bryce Platt, PharmD EP495 with Mick Connors, MD: Apple Podcasts | Spotify | Other Apps EP420 with Ge Bai, PhD, CPA: Apple Podcasts | Spotify | Other Apps EP422 with Benjamin Jolley, PharmD: Apple Podcasts | Spotify | Other Apps EP517 with Stacey: Apple Podcasts | Spotify | Other Apps LinkedIn Post by Bryce Platt, PharmD EP439 with Luke Slindee, PharmD: Apple Podcasts | Spotify | Other Apps LinkedIn Post by Patrick Moore EP465 with Chris Crawford: Apple Podcasts | Spotify | Other Apps === LINKS ===

Cancer has long been associated with aging, but in recent years, doctors have seen an alarming rise in colorectal cancer and other cancers among younger adults. In this episode of Health Matters, host Courtney Allison speaks with Dr. Dorna Jafari, chief of colorectal surgery at NewYork-Presbyterian Brooklyn Methodist Hospital, about what may be contributing to this growing public health concern. Dr. Jafari explains that colorectal cancer is now the leading cause of cancer death in people under age 50 and discusses the "birth cohort effect" researchers have identified among people born after 1960. She explores several factors that may be influencing cancer risk, including changes in diet, increased consumption of ultra-processed foods, disruptions to the gut microbiome, antibiotic exposure, and the growing presence of microplastics in the environment. The conversation also focuses on prevention. Dr. Jafari shares practical steps people can take to support a healthy microbiome and reduce cancer risk, including increasing fiber intake, staying physically active, limiting sugary beverages, and making realistic lifestyle changes over time. Finally, she discusses the exciting advances changing the future of oncology. From targeted cancer therapies and immunotherapy to AI-assisted diagnosis and improved screening tools, Dr. Jafari explains why cancer outcomes continue to improve and why early detection remains one of the most powerful tools available—especially when it comes to colorectal cancer screening. Chapters 00:00 – Why Are More Young People Getting Cancer? Understanding the rise of early-onset cancers and why colorectal cancer rates are increasing in adults under 50 03:15 – Diet, Microbiome, and Environmental Risks How ultra-processed foods, sugary drinks, antibiotics, and microplastics may influence cancer risk 07:20 – New Advances in Cancer Treatment The shift toward targeted therapies, immunotherapy, AI, and personalized cancer care 10:15 – Screening, Prevention, and Living Healthier Why colonoscopies remain the gold standard and the lifestyle habits that can help lower risk Key Topics Covered Early-onset colorectal cancer Rising cancer rates in young adults Colorectal cancer mortality trends Ultra-processed foods and cancer risk Sugar-sweetened beverages Gut microbiome health Antibiotic exposure and cancer Microplastics and potential health effects Fiber and digestive health Cancer prevention strategies Targeted cancer therapies Immunotherapy Artificial intelligence in oncology Colonoscopy screening Blood-based cancer screening tests Fertility preservation during cancer treatment Holistic cancer care Cancer survivorship and outcomes Key Takeaway While cancer is increasingly affecting younger adults, there are meaningful steps people can take to reduce their risk. Prioritizing screening, maintaining a healthy diet rich in fiber, limiting ultra-processed foods and sugary drinks, staying active, and paying attention to symptoms can make a difference. At the same time, advances in targeted therapies, immunotherapy, and AI-driven diagnostics are helping improve outcomes and offering new hope for the future of cancer care. Doctor Bio Dr. Mehraneh Dorna Jafari is chief of colorectal surgery at NewYork-Presbyterian Brooklyn Methodist Hospital and associate professor of surgery at Weill Cornell Medicine. She is the director of clinical research in the department of surgery at NewYork-Presbyterian/Weill Cornell Medical Center. She is board-certified in general surgery and colon and rectal surgery. Dr. Jafari specializes in the comprehensive care of colorectal cancer patients, patients with peritoneal surface disease as well as those patients with benign colorectal disease. Dr Jafari works with a world-renowned group of multidisciplinary specialists to help promote a patient centered treatment plan for her patients, including radiation oncologists, medical oncologists, radiologists, pathologists, gastroenterologists, and interventional radiologists. Her goal is to provide precision medicine to patients that is safe and effective. Dr. Jafari has expertise in minimal access techniques, including laparoscopic, and robotic surgery. In addition, she has special interests in sphincter preserving surgery (helping rectal cancer patients avoid a permanent ostomy), maintaining fertility in cancer patients, and improving quality of life and bowel function after rectal surgery.  Dr Jafari has been at forefront of research with regards to improving outcomes using enhanced recovery and narcotic sparing protocols. Dr. Jafari is among a small number of surgeons who offers surgery for metastatic colon, appendiceal and peritoneal surface disease. She utilizes cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), which involves heated chemotherapy applied directly within the abdominal cavity following removal of cancerous tumors. Dr. Jafari's clinical research focuses on quality of life and oncological outcomes for colorectal cancer patients. Her main area of expertise is starting chemotherapy earlier in cancer treatment to allow patients to recover their quality of life sooner. Dr. Jafari has written extensively and published in many major journals, including the Journal of the American Medical Association (JAMA), Annals of Surgery, and the Journal of the American College of Surgeons. She has led numerable courses teaching surgeons around the country how to perform minimal invasive surgery. Dr. Jafari is actively involved in many national surgical and oncologic societies, including the American College of Surgeons, Society of Surgical Oncologists, American Society of Colon and Rectal Surgeons and Association of Women Surgeons.

The Blasters & Blades PodcastToday, we are interviewing the stellar team of authors behind The Annals of the Auran Empire live on BackerKit! If you love classic, high-stakes epic fantasy, incredible worldbuilding, and supporting independent creators, this is the interview you've been waiting for. Tune in as the authors share exclusive story details, talk about the art of writing in a shared universe, and explain why this campaign is a must-back for fantasy lovers. Listen to the episode, head over to their BackerKit page, and claim your place in the Empire! Seriously, this was a fun interview, so go check it out. Co-Hosts:JR Handley (Author) (Grunt)Nick Garber (Comic Book Artist) (Super Grunt)Madam Stabby Stab (Uber Fan) (Horror Nerd)Jana S Brown (Author) (Chief Shenanigator)We work for free, so if you wanna throw a few pennies our way there is a linked Buy Me A Coffee site where you can do so. Just mention the podcast in the comments when you donate, and I'll keep the sacred bean water boiling!Support the Show: https://www.buymeacoffee.com/AuthorJRHandley Our LinkTree: https://linktr.ee/blastersandbladespodcast Today's SponsorThe Annals of the Auran Empire Crowdfunding: https://www.backerkit.com/call_to_action/8b8be898-82a5-4dc9-868d-aa9a9b449f6e/landing Follow Alexander Macris on social mediaAlexander's Amazon: https://www.amazon.com/stores/Alexander-Macris/author/B00O0I1S9AAlexander's Website: https://www.autarch.co/Alexander's Twitter: https://x.com/archonAlexander's Facebook: https://facebook.com/AutarchCo Alexander's YouTube: https://www.youtube.com/@TheArbiterOfWorldsAlexander's Patreon: https://www.patreon.com/c/AutarchAlexander's Substack: https://arbiterofworlds.substack.com/Alexander's Alternate Website: https://www.autarchemporium.com/Follow B.K. Gibson on social mediaGibson's Amazon: https://www.amazon.com/author/bkgibsonwriterGibson's Website: https://www.bkgibson.com/Gibson's Facebook: https://www.facebook.com/profile.php?id=61589323534470Gibson's Podcast: https://www.youtube.com/@DirtbaggeryBookReviews/streamsFollow Sam Robb on social mediaSam's Amazon: https://www.amazon.com/author/samrobbSam's Website: https://www.samrobbwrites.com/Sam's Twitter: https://x.com/SamRobbWritesSam's Facebook: https://www.facebook.com/samrobbwritesSam's Instagram: https://www.instagram.com/samrobbwrites/Sam's Substack: https://samrobbwrites.substack.com/Sam's Goodreads: https://www.goodreads.com/author/show/21563661.Sam_RobbFollow Zane Voss on social mediaZane's Amazon: www.amazon.com/stores/Zane-Voss/author/B087V3J7HJZane's Website: https://zanevoss.substack.com/Zane's Twitter: https://x.com/ZaneVoss#scifishenanigans #scifishenaniganspodcast #bbp #blastersandblades #blastersandbladespodcast #podcast #scifipodcast #fantasypodcast #scifi #fantasy #books #rpg #comics #fandom #literature #comedy #veteran #army #armyranger #ranger #scififan #redshirts #scifiworld #sciencefiction #scifidaily #scificoncept #podcastersofinstagram #scificons #podcastlife #podcastsofinstagram #scifibooks #awardwinningscifi #newepisode #podcastersofinstagram #podcastaddict #podcast #scifigeek #scifibook #sfv #scifivisionaries #firesidechat #chat #panel #fireside #religionquestion #coffee #tea #coffeeortea #CoffeeBrandCoffee #JRHandley #NickGarber #MadamStabby #JanaSBrown #JenaRey #OpalKingdomPress #AlexanderMacris #Archon #BKGibson #SamRobb #ZaneVoss #Backerkit #AnnalsOfTheAuranEmpire #Crowdfunding #elf #dwarves #halfling #Gnomes #HalfOrc #ogres #troll #minion #human #sword #LotR #LordOfTheRings #Tolkien #JRRTolkien #Andúril #FlameOfTheWest #Glamdring #Foe-hammer #HammerOfTheEnemy #Sting #Gúthwinë #Battle-friend #Herugrim #FierceSword #Orcrist #Goblin-cleaver #TheSilmarillion #Narsil #Anglachel #Gurthang #Ringil #Aranrúth #archer #bow #crossbow #LongBow #SwordAndShield #Sword&Shield #Sledgehammer #ChainSword #Warhammer40K #Axe #Battleaxe #Conan #ConanTheBarbarian #Barbarian #HALO

There's no shortage of health advice these days—but more information doesn't always lead to better results.Every day we're told to try a new diet, buy another supplement, follow the latest trend, or completely change the way we eat. The problem isn't that all of the advice is wrong. It's that most of it is just noise.In this episode, I break down one of the most important lessons I've learned on my own health journey: how to separate the signal from the noise. We also explore what decades of research on successful weight maintenance reveal about the habits that actually move the needle—and why consistency will always beat perfection.In this episode: What "signal vs. noise" means for your health  Why more information isn't always the answer  The common habits of people who lose weight and keep it off  Why quick recovery is more important than perfect consistency  How to stop letting one off-plan meal turn into weeks off track  The role of nutrition, movement, sleep, and self-monitoring  Why focusing on the fundamentals leads to lasting success Key Takeaways: Prioritize nutritious foods most of the time.  Move your body consistently.  Pay attention to your habits without becoming obsessive.  Protect your sleep and recovery.  When life happens, get back to your routine as quickly as possible. You don't need another diet, another supplement, or another health hack.You need a better filter.When you learn to tune out the noise and focus on the habits that truly matter, sustainable health becomes much simpler.References National Weight Control Registry. Long-term studies of successful weight-loss maintainers.Rena R. Wing & James O. Hill. Research on long-term weight-loss maintenance behaviors.Arlet V. Nedeltcheva et al. (2010). Insufficient Sleep Undermines Dietary Efforts to Reduce Adiposity. Annals of Internal Medicine.American College of Sports Medicine. Physical activity recommendations for adults.Centers for Disease Control and Prevention. Adult sleep and healthy lifestyle recommendations.Support the showGet Weekly Health Tips:  thrivehealthcoachllc.comJoin the Thrive Collective Facebook groupLet's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.comPodcast Produced by Virtually You!

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-493 Overview: Chronic kidney disease (CKD) is increasingly managed in primary care—but are you up to date on the latest guidance? This episode reviews current clinical practice guidelines and standards of care to help you confidently diagnose and classify CKD, apply evidence-based management strategies, and know when nephrology referral is warranted. Episode resource links: https://doi.org/10.7326/ANNALS-25-03499 Diabetes Care. 2024;48(Supplement_1):S239-S251. doi:10.2337/dc25-S011 Guest: Robert A. Baldor MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-493 Overview: Chronic kidney disease (CKD) is increasingly managed in primary care—but are you up to date on the latest guidance? This episode reviews current clinical practice guidelines and standards of care to help you confidently diagnose and classify CKD, apply evidence-based management strategies, and know when nephrology referral is warranted. Episode resource links: https://doi.org/10.7326/ANNALS-25-03499 Diabetes Care. 2024;48(Supplement_1):S239-S251. doi:10.2337/dc25-S011 Guest: Robert A. Baldor MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

In this episode of Keeping Abreast, Dr. Jenn Simmons sits down with Ivy Harris, a homeschool mom of four, researcher, and soon-to-be certified homeopath behind the blog Done with Diligence, for part one of a two-part conversation on the hidden risks of mammograms and breast cancer screening. Ivy is not a doctor. She's a mom who decided she wasn't going to walk into her first mammogram without doing her own homework first, and what she found is the reason this episode exists.It started with one post, Ivy broke down what she'd learned about mammograms into five parts, shared it, and watched it split her audience in half, with some women thanking her and others telling her she was going to get people killed. Dr. Jenn picks up exactly where Ivy left off and does the math no one does at check-in: 40 million screening mammograms a year, and by the numbers in the study Ivy found, the radiation alone works out to tens of thousands of cancers and over a thousand deaths a year. This is the episode you'll want to send to every woman who's ever been told a mammogram is simply safe, simply necessary, and not worth questioning.What You'll LearnThe naming decision behind "mammogram" that Dr. Jenn says was never an accidentIonizing radiation is a classified carcinogen, and why radiologists won't apply that logic to their own testThe cross-country flight radiation comparison doctors use to reassure you, and why it doesn't hold upHow breast density and size can mean 10x more radiation for one woman than another in the same mammogramWhy younger breast tissue takes more damage from radiation as screening age keeps getting pushed lowerOverdiagnosis: the NIH's own number is as high as 1 in 2 women screenedWhy DCIS, diagnosed in 90,000 women a year, has no physical route to become life-threatening breast cancerHow standard DCIS treatment can raise heart failure and fracture risk higher than the diagnosis itselfFalse positives and the 80% benign biopsy rate hiding behind every mammogram callbackWhat a 2026 American College of Physicians paper found on mammograms and breast cancer mortality, at every ageWhy decades of mammography have increased mastectomies by 20%, the opposite of what screening promisedLead time bias: how a screening test can look life-saving on paper without changing when anyone actually diesThe UK surgeon forced to resign for telling women the truth about mammogram screeningEpisode Timeline:00:00 Introducing Ivy Harris and Done with Diligence02:27 Why Ivy researched mammogram safety before her first screening03:00 Going past the rumors to the actual breast cancer research04:13 Her viral mammogram post and the backlash that followed05:32 Standing firm on breast cancer screening controversy07:39 Radiation risks: why a mammogram is a breast x-ray09:12 The studies linking mammogram radiation to breast cancer11:14 How radiation damages younger breast tissue13:36 The math: 40 million mammograms and radiation-induced cancer deaths17:59 Overdiagnosis and unnecessary breast cancer treatment26:14 The train analogy for mammogram overdiagnosis28:12 How breast cancer actually progresses versus the screening myth32:29 The real harm of overdiagnosis and overtreatment34:54 Why mammograms don't reduce all-cause breast cancer mortality50:15 Lead time bias and misleading screening survival statistics52:04 Michael Baum, saving breasts, and a Part 2 previewResources Mentioned:American College of Physicians, Annals of Internal Medicine, April 2026: https://www.acpjournals.org/doi/10.7326/M22-3424Guest: Ivy HarrisWhere to find her: Done with Diligence  & @donewithdiligenceTo talk to a member of Dr. Jenn's team and learn more about working privately with Dr. Jenn visit: https://calendly.com/stephanie-1031/clarity-callTo get your copy of Dr. Jenn's book, The Smart Woman's Guide to Breast Cancer, visit: https://tinyurl.com/SmartWomansBreastCancerGuideTo purchase the auria breast cancer screening test go here https://auria.care/ and use the code DRJENN20 for 20% Off.Connect with Dr. Jenn:Website: https://www.jennsimmonsmd.com/Facebook: https://www.facebook.com/DrJennSimmonsInstagram: https://www.instagram.com/drjennsimmons/YouTube: https://www.youtube.com/@dr.jennsimmons

Dr Nuno Castel-Branco is a Research Fellow at All Souls College, Oxford. He completed his Ph.D. in the history of science at Johns Hopkins University in 2021 after earning a Bachelor's and Master's in Physics at the University of Lisbon. Previously, he worked as a Research Fellow at Harvard University's Villa I Tatti in Florence and at the Max Planck Institute for the History of Science in Berlin. His first book, The Traveling Anatomist: Nicolaus Steno and the Intersection of Disciplines in Early Modern Science was published by the University of Chicago Press in October 2025. Dr Castel-Branco's research has been generously supported by institutions such as the Fulbright Program, the Andrew Mellon Foundation, the Royal Society and, more recently, the John Fell Fund from the University of Oxford. His writing has also appeared in publications such as Isis, Renaissance Quarterly and Annals of Science, as well as in the Wall Street Journal, The Washington Post and Scientific American.Substack "Stories of Science" https://nunocastelbranco.substack.com/Link to book: https://www.amazon.com/Traveling-Anatomist-Nicolaus-Intersection-Disciplines/dp/0226842290

In this new episode of Speaking of SurgOnc, Dr. Rick Greene & Dr. Aatur Singhi discuss the article: "PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study" from the April 2026 issue of the Annals of Surgical Oncology.

LISTENER DISCRETION IS ADVISED!!! References: Carunchio, M. (July 2020). Atypical Stroke Presentations. EMS World. Available: https://www.hmpgloballearningnetwork.com/site/emsworld/article/1224541/atypical-stroke-presentations Clawson, J. J., Scott, G., Gardett, I., et al. (2016). Predictive Ability of an Emergency Medical Dispatch Stroke Diagnostic Tool in Identifying Hospital-Confirmed Strokes. Journal of Stroke and Cerebrovascular Diseases, 25, 2031-2042. Gardett, Olola, Scott, Broadbent, & Clawson. (March 22, 2017). Comparison of EMD Stroke Identification and Paramedic On-Scene Stroke Assessment. Annals of Emergency Dispatch & Response. Peter Antevy Substack Article on RQI. Available: https://handtevymd.substack.com/p/jalen-brunson-didnt-win-a-championship?r=khz4&utm_campaign=post-expanded-share&utm_medium=post%20viewer&triedRedirect=true Prehospital Stroke ID Article: Caffarelli M, Wood AJ, Crowe RP, Amorim E, Kamel H, Kim AS, Guterman EL. PMID: 39398987.

The same glucosamine pill millions take for joint pain may protect a healthy brain — and accelerate Alzheimer's in a brain already in decline. Here's the science.In this episode of Health Longevity Secrets, Robert Lufkin MD breaks down the 2026 plot twist on glucosamine and dementia: why a supplement once hailed as a longevity hack now carries an Alzheimer's warning, and why the answer comes down to one thing — the state of your metabolism. The same molecule helped the metabolically healthy and may have harmed the metabolically broken. The supplement didn't change; the soil it landed on did.Chapters:00:00 — Introduction00:39 — The Supplement Everyone Trusted01:06 — UK Biobank: Glucosamine and 15% Lower Death Risk01:38 — Why Glucosamine Looked Like a Longevity Hack02:48 — The 2026 Plot Twist: Nature Metabolism Study03:53 — Alzheimer's Mice and the Glucosamine Pathway04:13 — How Sugar Tagging (Glycosylation) Explains Both04:57 — Hyperglycosylation in the Alzheimer's Brain05:34 — The Honest Caveat: Association vs Causation06:55 — The Takeaway: Metabolic Health Decides EverythingKey takeaways:In healthy, cognitively normal adults, regular glucosamine use has been tied to lower all-cause mortality and lower risk of dementia — especially vascular dementia.A June 2026 University of Florida study in Nature Metabolism found the opposite signal in sick brains: in people with mild cognitive impairment, glucosamine use was associated with a 25% higher likelihood of progressing to Alzheimer's, and a 25% higher death risk in those already diagnosed.In Alzheimer's mice, glucosamine made memory worse; blocking the same sugar-tagging pathway made it better.The mechanism is metabolic: glucosamine feeds glycosylation (sugar-tagging of proteins). A healthy brain handles it fine; an Alzheimer's brain is already hyperglycosylated, so adding more is "pouring gasoline on the fire."This is association, not proof of cause — and the literature is genuinely mixed. If you're healthy, it's not a fire alarm. If you or a loved one has MCI or dementia, talk to your physician before the next refill.Studies & sources:Hawkinson et al., "Hyperglycosylation is a metabolic driver of Alzheimer's disease," Nature Metabolism 2026 (University of Florida)University of Florida news release on the glucosamine–dementia findingZheng et al., "Association of regular glucosamine use with incident dementia," BMC Medicine 2023 (UK Biobank)Habitual glucosamine use, APOE genotypes, and cause-specific dementia in older adults (UK Biobank)Li et al., "Associations of regular glucosamine use with all-cause and cause-specific mortality," Annals of the Rheumatic Diseases 2020 (UK Biobank)Read Dr. Lufkin's book "Lies I Taught in Medical School".⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPart 1 focuses on the drum as an ancient technology of altered consciousness. The argument is not that every beat causes trance, or that neuroscience has proven spirits. The stronger argument is that rhythm enters the human organism through hearing, motor prediction, breath, movement, attention, emotion, expectation, culture, and social synchrony. The drum becomes powerful when sound, body, group, ritual frame, and meaning converge. These sources support the archaeology, neuroscience, EEG research, shamanic studies, possession studies, Indigenous and culturally specific drum traditions, ritual theory, placebo and meaning-response research, ceremonial magic, and modern witchcraft material used in the episode.Core Academic and Scientific SourcesHuels, Emma R., Hyoungkyu Kim, UnCheol Lee, Tirsa Bel-Bahar, Ana V. Colmenero, Alexandra Nelson, Stefanie Blain-Moraes, George A. Mashour, and Richard E. Harris. “Neural Correlates of the Shamanic State of Consciousness.” Frontiers in Human Neuroscience 15 (2021): 610466.Gordon, Yoel, Golan Karvat, Noa Dagan, and Ayelet N. Landau. “Neural Tracking at Theta Predicts Drumming-Induced Altered States of Consciousness.” Scientific Reports 16, no. 1 (2026): Article 10204.Aparicio-Terrés, R., et al. “The Neurobiology of Altered States of Consciousness Induced by Drumming and Other Rhythmic Sound Patterns.” Annals of the New York Academy of Sciences, 2025.Neher, Andrew. “Auditory Driving Observed with Scalp Electrodes in Normal Subjects.” Electroencephalography and Clinical Neurophysiology 13 (1961): 449–451.Neher, Andrew. “A Physiological Explanation of Unusual Behavior in Ceremonies Involving Drums.” Human Biology 34, no. 2 (1962): 151–160.Maurer, R., V. K. Kumar, L. Woodside, and R. J. Pekala. “Phenomenological Experience in Response to Monotonous Drumming and Hypnotizability.” American Journal of Clinical Hypnosis 40, no. 2 (1997): 130–145. Use for monotonous drumming, subjective altered experience, imagery, absorption, and hypnotizability.Maxfield, Melinda C. “Effects of Rhythmic Drumming on EEG and Subjective Experience.” PhD diss., Institute of Transpersonal Psychology, 1990. Use as older supporting context on drumming, EEG, imagery, body-image changes, and subjective altered experience. Do not make this the main scientific proof; use it as background.Nozaradan, Sylvie, Isabelle Peretz, and André Mouraux. “Tagging the Neuronal Entrainment to Beat and Meter.” The Journal of Neuroscience 31, no. 28 (2011): 10234–10240. Use for EEG evidence that the brain can track beat and meter. This supports the claim that the brain does not merely hear rhythm as background sound; it can represent rhythmic structure in measurable ways.Nozaradan, Sylvie. “Exploring How Musical Rhythm Entrains Brain Activity with Electroencephalogram Frequency-Tagging.” Philosophical Transactions of the Royal Society B 369, no. 1658 (2014). Use as broader rhythm/EEG entrainment support. This helps explain frequency-tagging, beat tracking, meter, neural entrainment, and the measurable relationship between rhythmic structure and brain activity.Thaut, Michael H., Gerald C. McIntosh, and Volker Hoemberg. “Neurobiological Foundations of Neurologic Music Therapy: Rhythmic Entrainment and the Motor System.” Frontiers in Psychology 5 (2015). Use for rhythm as motor-system timing information. This supports the claim that a beat can become bodily instruction, not just sound for the ear. Especially useful when discussing rhythmic auditory stimulation, motor planning, gait, entrainment, and the auditory-motor bridge.Ross, Jessica M., John R. Iversen, and Ramesh Balasubramaniam. “Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction.” 2022. Use for rhythm, timing, prediction, sensorimotor entrainment, and the way musical rhythm interacts with time perception.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960. Use for synchrony and social bonding. This helps support the group-body argument: moving or acting in time with others can increase affiliation.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5. Use for the claim that synchronized movement can increase cooperation and attachment among participants.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096. Use for music, synchrony, bonding, endorphin/social mechanisms, and why group rhythm can feel like more than private listening.Fancourt, Daisy, Rosie Perkins, Sara Ascenso, Louise Atkins, Fatima Kilfeather, and Aaron Williamon. “Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users.” PLOS ONE 11, no. 3 (2016): e0151136. Use for modern group-drumming research showing psychological and physiological effects, including anxiety, depression, social resilience, wellbeing, and inflammatory immune response. Use carefully: this does not make group drumming a cure-all. It supports the more grounded claim that embodied rhythm and group participation can affect mood, social connection, and body chemistry.Bittman, Barry B., et al. “Composite Effects of Group Drumming Music Therapy on Modulation of Neuroendocrine-Immune Parameters in Normal Subjects.” Alternative Therapies in Health and Medicine 7, no. 1 (2001): 38–47. Use as older supporting material on group drumming and neuroendocrine-immune measures. Keep secondary. Fancourt is cleaner for the main script body.Archaeology and Deep History of DrumsLawergren, Bo. “Neolithic Drums in China.” In Music Archaeology in China. 2006. Use for clay drums in Neolithic China and the deep-history claim that drums are not just poetic symbols of antiquity. They appear in the archaeological record as instruments tied to early sound-making, ceremony, and social order.Both, Arnd Adje. “Music Archaeology: Some Methodological and Theoretical Considerations.” Use as general support for why ancient instruments should be treated as ritual and social evidence, not merely decorative objects.Anthropology, Ethnomusicology, Ritual, and TranceRouget, Gilbert. Music and Trance: A Theory of the Relations Between Music and Possession. Translated by Brunhilde Biebuyck. Chicago: University of Chicago Press, 1985. Essential source. Use for the caution that music does not mechanically or universally cause trance. Rouget helps keep the argument academically serious by emphasizing culture, ritual frame, meaning, and expectation.Becker, Judith. Deep Listeners: Music, Emotion, and Trancing. Bloomington: Indiana University Press, 2004. Use for music-linked trancing, emotional absorption, religious experience, and culturally trained ways of listening. This supports the “hearing versus entering” distinction.McNeill, William H. Keeping Together in Time: Dance and Drill in Human History. Cambridge, MA: Harvard University Press, 1995. Use for marching, dance, drill, muscular bonding, synchronized movement, and rhythm as social glue. This is useful both for Part 1's group-body material and Part 2's war-drum material.Eliade, Mircea. Shamanism: Archaic Techniques of Ecstasy. Princeton: Princeton University Press, 1964. Use carefully. Eliade's phrase “archaic techniques of ecstasy” is powerful, but the episode should also note that later scholarship criticizes his tendency to universalize shamanism.Winkelman, Michael. Shamanism: A Biopsychosocial Paradigm of Consciousness and Healing. 2nd ed. Santa Barbara, CA: Praeger, 2010. Use for shamanism as a ritual technology involving altered consciousness, healing, social integration, symbolism, and body-brain processes.Winkelman, Michael. “Shamanism and Psychedelics: A Biogenetic Structuralist Paradigm of Ecopsychology.” European Journal of Ecopsychology 4 (2013): 90–115. Use as supplemental background on shamanism, altered consciousness, and comparative models of trance and visionary states.Kontouli, Athanasia, Michael J. Hove, Alexandre Lehmann, Peter Vuust, and Peter E. Keller. “The Rhythms of Trance: Cultural Phenomenology and Neural Mechanisms of Music-Induced Lewis-Williams, David. The Mind in the Cave: Consciousness and the Origins of Art. London: Thames & Hudson, 2002. Use cautiously for altered states, entoptic imagery, ritual vision, and the relationship between neuropsychology and symbolic culture.Non-Ordinary States of Consciousness.” Neuroscience & Biobehavioral Reviews, 2026. Use for the bridge between cultural phenomenology and neuroscience. This supports the point that music-induced trance is not only acoustics; it involves body, training, expectation, culture, environment, and interpretation.Tart, Charles T., ed. Altered States of Consciousness. New York: Wiley, 1969. Use as classic altered-state background.Hultkrantz, Åke. “The Drum in Shamanism.” Use for classic comparative material on the shamanic drum, especially Arctic, SiberiAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

What if one of the most important health crises affecting men today wasn't being caused by aging, but by the environment we live in? In this eye-opening solo episode, Darin Olien investigates the alarming decline in testosterone levels, fertility, and reproductive health among men worldwide. Drawing on decades of research, epidemiological studies, environmental science, endocrinology, and public health data, Darin examines the growing evidence connecting endocrine-disrupting chemicals, microplastics, sleep deprivation, chronic stress, poor lifestyle habits, and environmental toxins to declining testosterone levels across generations. From BPA, phthalates, atrazine, PFAS, and microplastics to sleep quality, circadian rhythms, cholesterol metabolism, cortisol regulation, and natural testosterone-supporting strategies, this episode explores what may be one of the most underreported public health issues of our time—and what men can do to take control of their health today.     What You'll Learn Why testosterone levels have been declining for decades The startling research on global sperm count decline How endocrine-disrupting chemicals interfere with hormone production Why BPA and phthalates may disrupt testosterone synthesis The role of atrazine, PFAS, and environmental toxins How chronic stress diverts resources away from testosterone production Why sleep may be the most important testosterone intervention The connection between cholesterol and hormone production How microplastics are being found throughout the human body The surprising relationship between statins and testosterone levels Natural lifestyle strategies that support healthy hormone production Practical steps to reduce environmental exposure and improve health     Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Fatty15 and cellular health 00:04:17 – The testosterone collapse explained 00:04:51 – Testosterone levels have been declining for decades 00:06:03 – Global sperm count decline and accelerating trends 00:07:02 – Why treating symptoms misses the root cause 00:07:27 – The hidden public health crisis 00:08:03 – Why low testosterone isn't just about aging 00:09:12 – Why hormone health affects longevity 00:09:53 – Low testosterone and increased mortality risk 00:10:35 – Testosterone's role in metabolism and cardiovascular health 00:11:27 – Endocrine-disrupting chemicals and hormone disruption 00:12:44 – BPA and its effects on testosterone production 00:13:59 – Phthalates and their impact on hormone pathways 00:16:00 – Glyphosate, atrazine, and pesticide exposure 00:17:07 – PFAS and reproductive health concerns 00:17:55 – Environmental toxins and population-wide effects 00:18:11 – Sponsor: Shakeology 00:20:02 – Cholesterol and hormone production 00:20:53 – Chronic stress and cortisol dominance 00:21:45 – Actionable solutions begin 00:21:56 – Why sleep is essential for testosterone production 00:23:07 – How sleep deprivation rapidly lowers testosterone 00:23:21 – Light pollution and circadian disruption 00:23:41 – Foods and nutrients needed for hormone health 00:24:23 – Microplastics and testicular tissue 00:24:53 – Statins and unintended hormonal consequences 00:25:39 – A practical testosterone sovereignty protocol 00:25:48 – Water filtration and reducing toxic exposure 00:26:13 – Eliminating plastics and fragrance chemicals 00:26:35 – Why organic food matters 00:26:45 – Sunlight and vitamin D 00:27:05 – Magnesium, omega-3s, and iodine 00:27:26 – Pine pollen and natural androgen support 00:28:01 – Tongkat Ali and ashwagandha 00:28:48 – Strength training and lifestyle interventions 00:29:10 – Habits that naturally support testosterone 00:29:27 – Darin's approach to healthy aging 00:29:37 – Plants, herbs, and common sense 00:29:51 – Reclaiming your health and sovereignty 00:30:00 – Final thoughts and closing message     Thank You to Our Sponsors Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Shakeology: Get 15% off with code DARINO1BODI at Shakeology.com.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness     Key Takeaway "The testosterone crisis may be about far more than aging. It may be a reflection of the modern environment itself—one increasingly saturated with endocrine-disrupting chemicals, chronic stress, poor sleep, circadian disruption, and toxic exposures. While many of these forces feel outside our control, the encouraging reality is that many of the most powerful interventions remain accessible: improving sleep, reducing toxic load, eating whole foods, getting sunlight, managing stress, exercising regularly, and reclaiming responsibility for our health. The goal isn't fear. The goal is awareness—and action."     Bibliography/Sources: The Decline — Primary Research Levine, H., Jørgensen, N., Martino-Andrade, A., et al. (2022). Temporal trends in sperm count: A systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Human Reproduction Update, 29(2), 157–176. https://doi.org/10.1093/humupd/dmac035 Lokeshwar, S. D., Patel, P., Fantus, R. J., et al. (2021). Decline in testosterone levels in men aged 15–40: Results from the National Health and Nutrition Examination Survey (NHANES), 1999–2016. World Journal of Urology, 39(2), 447–452. https://doi.org/10.1007/s00345-020-03227-1 Spital Clinic. (2026, March). Declining testosterone levels by generation. https://www.spitalclinic.com Travison, T. G., Araujo, A. B., O'Donnell, A. B., Kupelian, V., & McKinlay, J. B. (2007). A population-level decline in serum testosterone levels in American men. The Journal of Clinical Endocrinology & Metabolism, 92(1), 196–202. https://doi.org/10.1210/jc.2006-1375 Low Testosterone — Mortality & Disease Risk Muraleedharan, V., Marsh, H., Kapoor, D., Channer, K. S., & Jones, T. H. (2013). Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. European Journal of Endocrinology, 169(6), 725–733. https://doi.org/10.1530/EJE-13-0321 Shores, M. M., et al. (2006). Low testosterone associated with increased all-cause and cardiovascular mortality. Archives of Internal Medicine, 166(15), 1660–1665. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/410754 Yeap, B. B., Marriott, R. J., Dwivedi, G., et al. (2024). Associations of testosterone and related hormones with all-cause and cardiovascular mortality and incident cardiovascular disease in men. Annals of Internal Medicine. https://doi.org/10.7326/M23-2781 Endocrine Disrupting Chemicals Associations between endocrine-disrupting chemical exposure and fertility outcomes: A decade of human epidemiological evidence. (2024). PubMed Central (PMC12299029). https://pmc.ncbi.nlm.nih.gov/articles/PMC12299029/ Hayes, T. B., Haston, K., Tsui, M., et al. (2002). Herbicides: Feminization of male frogs in the wild. Nature, 419, 895–896. https://doi.org/10.1038/419895a Mechanisms of testicular disruption from exposure to BPA and phthalates. (2020). Journal of Clinical Medicine, 9(2), 471. https://pmc.ncbi.nlm.nih.gov/articles/PMC7074154/ Meeker, J. D., Calafat, A. M., & Hauser, R. (2014). Urinary phthalate metabolites and their biotransformation products: Predictors and temporal variability among men and women. Journal of Exposure Science & Environmental Epidemiology. https://www.sciencedaily.com/releases/2014/08/140814124330.htm Zhao, Q., et al. (2023). Male reproductive toxicity of microplastics: Head and tail of the sperm. Science of the Total Environment, 872, 162181. https://doi.org/10.1016/j.scitotenv.2023.162181 Zhong, B., et al. (2024). Mixed EDC exposure associated with reductions in testosterone and free androgen index. Scientific Reports. https://doi.org/10.1038/s41598-024-76972-z Cortisol, Stress & the HPG Axis Bielohuby, M., et al. (2012). Swiss military cadets prolonged stress study. Psychoneuroendocrinology. Preprints.org. (2025). Sleep deprivation: A modifiable cause. https://doi.org/10.20944/preprints202505.0580.v1 SiPhox Health. (n.d.). Summary of Journal of Clinical Endocrinology & Metabolism data. https://www.siphoxhealth.com Viau, V. (2002). Functional cross-talk between the hypothalamic-pituitary-gonadal and -adrenal axes. Journal of Neuroendocrinology, 14(6), 506–513. https://doi.org/10.1046/j.1365-2826.2002.00798.x Sleep & Testosterone Leproult, R., & Van Cauter, E. (2011). Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA, 305(21), 2173–2174. https://jamanetwork.com/journals/jama/fullarticle/1029127 Reiter, R. J., et al. (2021). Melatonin and male reproductive health: Relationship to oxidative stress, mitochondrial function, and Leydig cell protection. Endocrine. Tan, D. X., Hardeland, R., Manchester, L. C., et al. (2023). Melatonin as a pleiotropic antioxidant hormone. Journal of Pineal Research. Nutrition — Zinc, Vitamin D, Cholesterol Corona, G., et al. (2010). Statin therapy and testosterone levels in men: A systematic review. The Journal of Sexual Medicine. Daniell, H. W. (2002). Hypogonadism in men consuming sustained-action oral opioids. The Journal of Pain, 3(5), 377–384. https://doi.org/10.1054/jpai.2002.126790 Pilz, S., Frisch, S., Koertke, H., et al. (2011). Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43(3), 223–225. https://doi.org/10.1055/s-0030-1269854 Prasad, A. S., Mantzoros, C. S., Beck, F. W., Hess, J. W., & Brewer, G. J. (1996). Zinc status and serum testosterone levels of healthy adults. Nutrition, 12(5), 344–348. https://doi.org/10.1016/S0899-9007(96)80058-X Natural Testosterone Support — Botanical Evidence Pine pollen impacts testosterone-related symptoms in men. (2024). ACMCR Case Reports, 14(5), 1–9. Chinnappan, S. M., George, A., et al. (2021). Effect of Eurycoma longifolia standardised extract Physta on testosterone levels in ageing males: A randomised, double-blind, placebo-controlled multicentre study. Food & Nutrition Research, 65. https://doi.org/10.29219/fnr.v65.5647 Lazarev, A., & Bezuglov, E. (2021). Testosterone boosters intake in athletes: Current evidence and further directions. Endocrines, 2(2), 109–120. https://doi.org/10.3390/endocrines2020011 Leisegang, K., et al. (2022). Eurycoma longifolia (Tongkat Ali) improves serum total testosterone in men. Food & Nutrition Research. https://pubmed.ncbi.nlm.nih.gov/36013514/ Leitão, A. E., et al. (2021). 6-month double-blind RCT: Eurycoma longifolia 200mg + concurrent training. Maturitas. https://doi.org/10.1016/j.maturitas.2020.10.005 Lopresti, A. L., Smith, S. J., et al. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha extract. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186 Pandit, S., Biswas, S., Jana, U., De, R. K., Mukhopadhyay, S. C., & Biswas, T. K. (2016). Clinical evaluation of purified shilajit on testosterone levels in healthy volunteers. Andrologia, 48(5), 570–575. https://doi.org/10.1111/and.12482 Saden-Krehula, M., Tajic, M., & Kolbah, D. (1971). Testosterone, epitestosterone and androstenedione in the pollen of Scotch pine Pinus sylvestris L. Experientia, 27(1), 108–109. https://doi.org/10.1007/BF02137731 Wankhede, S., Langade, D., Joshi, K., et al. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial. Journal of the International Society of Sports Nutrition, 12, 43. https://doi.org/10.1186/s12970-015-0104-9

This is The Briefing, a daily analysis of news and events from a Christian worldview.On today's edition of The Briefing, Dr. Mohler discusses the G7 and ceasefire with Iran, the thwarted drone attack at the White House, the collision of the Giants Pride night with religious liberty, and the two documents signed by Abraham Lincoln that will be on display at the Lincoln Memorial for America's 250th birthday.Part I (00:14 – 06:36)The G7 and the Ceasefire with Iran: President Trump Claims Victory Before World Leaders, But the Next 60 Days are CrucialPart II (06:36 – 13:20)A Thwarted Drone Attack at the White House: The Big Problem of Disaffected Young Men in the Digital AgePart III (13:20 – 21:50)Pride Night Collides with Religious Liberty and the San Francisco Giants: Three Pitchers Exercise Religious Freedom on Pride Night, and LGBTQ Revolutionaries are Up in ArmsMLB issues warning to Giants pitchers who wrote Bible verses on Pride Night caps by The Athletic (Steve Berman)Hawley Demands Answers from MLB for Penalizing Christian Players by U.S. Senator for Missouri (Senator Josh Hawley)Part IV (21:50 – 27:56)The Importance of Words in the Annals of History: Two Documents Signed by Abraham Lincoln Will Be on Display at the Lincoln Memorial for America's 250th BirthdayA look at the rare historic documents heading to the Lincoln Memorial by The Washington Post (Michael E. Ruane)Sign up to receive The Briefing in your inbox every weekday morning.Follow Dr. Mohler:X | Instagram | Facebook | YouTubeFor more information on The Southern Baptist Theological Seminary, go to sbts.edu.For more information on Boyce College, just go to BoyceCollege.com.To write Dr. Mohler or submit a question for The Mailbox, go here.

Doctor Mau Informa ®️ #drmauinforma Durante medio siglo, la endocrinología consideró al glucagón como el "villano" del metabolismo: la hormona responsable de subir el azúcar en la sangre. Sin embargo, ¿qué pasaría si pudiéramos domesticar a este villano para activar la quema extrema de grasa de forma segura. En este episodio de Doctor Mau Informa, analizamos la fascinante evolución científica que nos llevó desde tumores pancreáticos hasta el desarrollo del Retatrutide, un revolucionario fármaco "triple agonista". Descubre cómo la ciencia logró combinar tres señales hormonales (Glucagón, GLP-1 y GIP) en una sola inyección semanal para alcanzar resultados de pérdida de peso metabólica que antes solo le pertenecían al bisturí de la cirugía bariátrica. En este episodio aprenderás: → La balanza de la pérdida de peso: Por qué los medicamentos anteriores solo te quitaban el hambre, y cómo la nueva generación también acelera tu gasto energético. → El secreto del Glucagón: Cómo esta hormona del ayuno saca la grasa del hígado y eleva el metabolismo. → La evolución del GLP-1: El papel protector de la insulina natural para contrarrestar el azúcar y permitir una pérdida de peso segura. → Cirugía vs. Fármacos: Por qué los resultados de los nuevos tratamientos crónicos están cambiando el paradigma médico para siempre. → La realidad clínica: Efectos secundarios, la importancia de la titulación médica y por qué esto no es una "dieta milagro".

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBiblioBernardi, Luciano, Peter Sleight, Gabriele Bandinelli, Simone Cencetti, Luciano Fattorini, Johanna Wdowczyc-Szulc, and Alfonso Lagi. “Effect of Rosary Prayer and Yoga Mantras on Autonomic Cardiovascular Rhythms: Comparative Study.” BMJ 323, no. 7327 (2001): 1446–1449.Benson, Herbert, John W. Lehmann, Mark S. Malhotra, Ralph F. Goldman, Jeffrey Hopkins, and Mark D. Epstein. “Body Temperature Changes During the Practice of g Tum-mo Yoga.” Nature 295 (1982): 234–236.Benson, Herbert, Mark S. Malhotra, Ralph F. Goldman, Gregory D. Jacobs, and Jeffrey Hopkins. “Three Case Reports of the Metabolic and Electroencephalographic Changes During Advanced Buddhist Meditation Techniques.” Behavioral Medicine 16, no. 2 (1990): 90–95.Bremer, Brandon, Lorenzo Wu, Zoran Josipovic, and colleagues. “Mindfulness Meditation Increases Default Mode, Salience, and Central Executive Network Connectivity.” Scientific Reports 12 (2022).Brewer, Judson A., Patrick D. Worhunsky, Jeremy R. Gray, Yi-Yuan Tang, Jochen Weber, and Hedy Kober. “Meditation Experience Is Associated with Differences in Default Mode Network Activity and Connectivity.” Proceedings of the National Academy of Sciences 108, no. 50 (2011): 20254–20259.Britton, Willoughby B. and colleagues. Research associated with the “Varieties of Contemplative Experience” project on meditation-related challenges, adverse effects, and safety considerations in contemplative practice.Crowley, Aleister. Liber E vel Exercitiorum sub figura IX. In the A∴A∴ training corpus. Relevant sections include asana, pranayama, and dharana as foundational magical exercises.Dennison, Paul. “Insights From an EEG Study of Buddhist Jhāna Meditation.” Frontiers in Human Neuroscience 13 (2019).Fialoke, Shantala, Helen Weng, and colleagues. “Functional Connectivity Changes in Meditators and Novices During Yoga Nidra Practice.” Scientific Reports 14 (2024).Fox, Kieran C. R., Savannah Nijeboer, Matthew L. Dixon, James L. Floman, Melissa Ellamil, Samuel P. Rumak, Peter Sedlmeier, and Kalina Christoff. “Is Meditation Associated with Altered Brain Structure? A Systematic Review and Meta-analysis of Morphometric Neuroimaging in Meditation Practitioners.” Neuroscience & Biobehavioral Reviews 43 (2014): 48–73.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.Kozhevnikov, Maria, Olesya Louchakova, Zoran Josipovic, and Michael A. Motes. “The Enhancement of Visuospatial Processing Efficiency Through Buddhist Deity Meditation.” Psychological Science 20, no. 5 (2009): 645–653.Kozhevnikov, Maria, John A. Elliott, Jennifer Shephard, and Klaus Gramann. “Neurocognitive and Somatic Components of Temperature Increases During g-Tummo Meditation: Legend and Reality.” PLOS ONE 8, no. 3 (2013): e58244.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217.Lomas, Tim, Juan Carlos Ivtzan, and Itai K. Fu. “A Systematic Review of the Neurophysiology of Mindfulness on EEG Oscillations.” Neuroscience & Biobehavioral Reviews 57 (2015): 401–410.Lott, James P., Richard J. Davidson, John D. Dunne, Thupten Jinpa, Antoine Lutz, and colleagues. “No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam.” Frontiers in Psychology 11 (2021): 599190.Lutz, Antoine, Lawrence L. Greischar, Nancy B. Rawlings, Matthieu Ricard, and Richard J. Davidson. “Long-term Meditators Self-induce High-amplitude Gamma Synchrony During Mental Practice.” Proceedings of the National Academy of Sciences 101, no. 46 (2004): 16369–16373.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLoS ONE 3, no. 3 (2008): e1897.Matko, Karin, Peter Sedlmeier, and colleagues. “Adverse Effects of Meditation and Mindfulness in Clinical Practice.” 2025.Patanjali. Yoga Sutras. Especially Book III, traditionally describing dharana, dhyana, and samadhi.Riegner, Gretchen, Fadel Zeidan, and colleagues. “Disentangling Self from Pain: Mindfulness Meditation-Induced Pain Relief Is Driven by Thalamic-Default Mode Network Decoupling.” Pain 164, no. 2 (2023): 280–291.Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience 16 (2015): 213–225.Vago, David R., and David A. Silbersweig. “Self-awareness, Self-regulation, and Self-transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6 (2012): 296.Zeidan, Fadel, and colleagues. Research on mindfulness meditation, pain modulation, attention, and the neural mechanisms of pain relief.Slagter, Heleen A., Antoine Lutz, Lawrence L. Greischar, Andrew D. Francis, Sander Nieuwenhuis, James M. Davis, and Richard J. Davidson. “Mental Training Affects Distribution of Limited Brain Resources.” PLOS Biology 5, no. 6 (2007): e138. Use for: Attentional blink, limited attention, and meditation changing how the brain allocates resources.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43. Use for: Neuroplasticity, repeated practice leaving measurable marks on the brain, and the “practice writes itself into the practitioner” idea.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217. Use for: Predictive processing, the brain as a prediction machine, meditation loosening automatic models, and the “veil” argument.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLOS ONE 3, no. 3 (2008): e1897. Use for: Compassion meditation, loving-kindness, emotional circuitry, and training compassion as a repeatable state rather than just a moral idea.Kok, Bethany E., Kimberly A. Coffey, Michael A. Cohn, Lahnna I. Catalino, Tanya Vacharkulksemsuk, Sara B. Algoe, Marc A. Brantley, and Barbara L. Fredrickson. “How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone.” Psychological Science 24, no. 7 (2013): 1123–1132. Use for: Loving-kindness, social connection, vagal tone, and the cautious “social nervous system” bridge.Black, David S., and George M. Slavich. “Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences 1373, no. 1 (2016): 13–24. Use for: Immune-system caution, inflammation markers, cell-mediated immunity, biological aging, and why this material should be framed as tentative rather than miracle healing.Burić, Ivana, Miguel Farias, Jonathan Jong, Christopher Mee, and Inti A. Brazil. “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” Frontiers in Immunology 8 (2017): 670. Use for: Stress biology, inflammatory gene expression, NF-kB-related language, and the cautious claim that mind-body practices may affect biology below ordinary mood.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

La dernière fois que je me suis fait une bonne bouffe, une question a popé dans ma tête : les aliments, ils viennent d'où ? D'où arrivent les tomates, patates, échalotes, haricots, prunes et pêches qu'on mange, est-ce que tout ça poussait miraculeusement en Europe dès la Préhistoire ? Eh bien sans surprise, c'est non ! En fait, beaucoup de fruits et de légumes ont leur propre histoire et leur propre géographie ! Alors on se lance au cœur de la marmite pour enquêter sur leurs origines, toutes passionnantes !Bonne écoute !

You’re listening to American Ground Radio with Louis R. Avallone and Stephen Parr. This is the full show for June 11, 2026. We open with one of the most disturbing stories we've covered — federal officials have located 146,000 unaccompanied migrant children who entered the country during the Biden administration and disappeared into a broken government tracking system. Nearly half a million unaccompanied children were transferred into federal custody between 2019 and 2023, and the government lost track of three out of every four of them. Over 32,000 failed to appear for immigration court hearings — children who legally don't even have the capacity to be responsible for that. We point out that some sponsors used the same addresses and names over and over to claim multiple children — a hallmark of trafficking networks — and that acting Attorney General Todd Blanch confirmed this program was exploited for sexual assault and trafficking. We make the case that this level of failure isn't incompetence. It's a feature, not a bug, of an administration that prioritized volume over accountability — and we ask where these children go to get their childhoods back. In our Top 3 Things You Need to Know, President Trump paused another round of attacks on Iran after announcing a breakthrough in negotiations, with a final deal expected to be signed in Europe as early as this weekend — including guarantees Iran will never possess a nuclear weapon and that the Strait of Hormuz will reopen to shipping without Iranian tolls. Then the CEO of ActBlue refused to answer questions during a congressional hearing, repeatedly citing attorney-client privilege and Fifth Amendment protections amid allegations of fraudulent campaign donations including foreign contributions. And a Michigan court overturned the conviction of one of the men accused of plotting to kidnap Governor Gretchen Whitmer in 2020, ruling that kidnapping isn't a violent felony under Michigan's terrorism statute — we revisit the role the FBI itself played in organizing that plot. We also cover New York City Mayor Zoran Mamdani attending the NBA Finals at Madison Square Garden with a roughly $1,000 standing-room ticket — despite running a campaign built on taxing the wealthy and claiming he'd have to move back in with his parents due to financial strain. We make the broader point about socialism and its leaders — the people at the top always seem to find their way to the good seats while telling everyone else to live within their needs. Our American Mamas Teri Netterville and Kimberly Burleson tackle the question of whether MAGA is dead, as several prominent former Trump-aligned commentators have recently suggested. They point to Trump-endorsed candidates sweeping primaries in South Carolina, Louisiana, and Texas as evidence the movement is alive and well, and discuss the pattern of high-profile pundits — Megyn Kelly, Tucker Carlson, Candace Owens — making abrupt reversals after years of consistency, while Trump's messaging has remained the same. They draw a comparison to Ann Coulter's earlier break with Trump over the border wall timeline, suggesting some of these breaks come from single-issue voters whose patience ran out on one specific promise. We dig into the controversy over whether ICE enforcement should pause during the World Cup — with activists arguing that immigration enforcement makes undocumented immigrants feel unsafe attending games. We point out the absurdity by comparison — nobody argues pickpocketing laws should be suspended during the Super Bowl. In our Digging Deep segment, we cover the case of a Somali World Cup referee who was denied entry into the United States after Customs and Border Protection flagged his connections to Al-Shabaab, an Al-Qaeda affiliate — and his own social media posts containing antisemitic statements. We walk through why this isn't about ethnicity, despite Al-Shabaab itself issuing a statement calling it racial discrimination, and why a country has every right to keep people connected to designated terrorist organizations out, regardless of their profession. We also cover the first arrest from a new federal fraud task force's top-10 most-wanted list — a $100 million bank fraud case in Orange County involving falsified title insurance documents and altered digital metadata. For our Bright Spot, a new study out of the University of Maryland School of Medicine and published in the Annals of Family Medicine found that patients who received five minutes of intercessory prayer — including the laying on of hands — experienced significantly greater pain and anxiety reduction than those who listened to faith music or meditation, with benefits lasting up to six weeks. Remarkably, the results held regardless of whether the patient receiving prayer was a believer — what mattered was the faith of the person doing the praying. We connect it to the biblical example of the centurion asking Jesus to heal his servant, and note that researchers are now suggesting intercessory prayer become standard medical practice. And we close with Jimmy Kimmel mocking Spencer Pratt over losing his home in the LA wildfires by renting him a U-Haul — which we call exactly what it is, shameful — and the congressional baseball game, where Republicans beat Democrats 11-2, with Florida Rep. Greg Steube striking out five batters and Missouri Senator Eric Schmitt named MVP for a diving catch that left him bloodied. May your pursuit of happiness bring you joy. Listen now wherever you get your podcasts, visit AmericanGroundRadio.com, and join the conversation at 866-AGR-1776!See omnystudio.com/listener for privacy information.

CardioNerds (Drs. Rawan Amir, Tripti Gupta, and Alysha Joseph) discuss the fundamentals of adult congenital heart disease (ACHD) surgery with Dr. Elizabeth Stephens.  Audio editing by CardioNerds academy intern, Grace Qiu.  Using a case of a young adult undergoing a Ross procedure, the episode walks through what happens in the operating room—from induction and intraoperative transesophageal echocardiography (TEE) to cardiopulmonary bypass (CPB), myocardial protection, and surgical repair. The discussion highlights key concepts including cardioplegia, cross-clamp and bypass times, hypothermic circulatory arrest, and the complexity of redo sternotomy. This episode provides learners with a practical framework to interpret operative reports, anticipate postoperative physiology, and better collaborate with surgical teams. This episode was produced by the CardioNerds ACHD Council and planned by Dr. Rawan Amir.  CardioNerds Adult Congenital Heart Disease PageCardioNerds Episode Page Pearls “LV distension kills patients.”Preventing left ventricular distension with appropriate venting and awareness of aortic insufficiency is critical to intraoperative safety.  TEE can change the surgical plan in real time.Findings such as underestimated aortic regurgitation, mitral pathology, or a PFO may directly alter cannulation and cardioplegia strategy.  Cross-clamp time = myocardial ischemic time; bypass time = systemic stress.Both are key predictors of postoperative complications including renal injury, bleeding, and ventricular dysfunction.  Redo sternotomy risk is driven by anatomy, not just number.Aorta adherent to the sternum, conduit position, and chamber pressurization define risk more than the number of prior surgeries.  Think longitudinally—ACHD surgery is lifetime planning.Surgical materials and strategies must account for future interventions, especially in younger patients. Notes: Notes drafted by Dr. Alysha Joseph, aided by generative artificial intelligence. What are the key steps in congenital cardiac surgery from incision to closure? Preoperative planning is multidisciplinary, involving surgeon, anesthesia, cardiology, and ICU teams; high-risk inductions (e.g., critical AS, Williams syndrome) are identified early TEE is performed immediately after induction to reassess anatomy and may reveal new findings (e.g., underestimated AI, mitral disease, PFO) Median sternotomy is performed, followed by creation of a pericardial well to optimize exposure Heparin is administered prior to cannulation; arterial and venous cannulas are placed for initiation of CPB Cross-clamp is applied and cardioplegia delivered to arrest the heart, allowing a still and protected operative field Surgical repair (e.g., Ross procedure) is performed, followed by de-airing, cross-clamp removal, and reperfusion Patient is weaned from bypass with TEE reassessment, hemostasis achieved, and chest closed What is cardioplegia and how is it delivered? Cardioplegia is a potassium-rich solution that arrests myocardial activity and reduces metabolic demand Most commonly used solution in the U.S. is Del Nido cardioplegia, originally developed for pediatric myocardium Delivery strategies include: Antegrade (via aortic root) – standard approach  Ostial (direct coronary delivery) – used when aortic root cannot be relied upon  Retrograde (via coronary sinus) – useful in severe AI or coronary disease NOTE: Severe aortic regurgitation can impair antegrade delivery and requires alternative strategies and LV venting  What do cross-clamp time and bypass time represent clinically? Cross-clamp time = duration of myocardial ischemia while the heart is arrested Bypass time = total duration on CPB, reflecting systemic exposure to non-physiologic circulation Prolonged cross-clamp time (>2–3 hours) increases risk of myocardial dysfunction, especially with poor baseline function Longer bypass time is associated with increased risk of renal injury, coagulopathy, and bleeding These metrics often reflect both case complexity and intraoperative challenges What is hypothermic circulatory arrest (HCA) and when is it used? HCA involves complete cessation of blood flow to allow a bloodless surgical field Typically used in complex aortic arch repairs Patients are cooled to ~18°C to reduce metabolic demand and protect organs Duration is ideally limited to

In this powerful episode of Master Your Marriage, Sharla and Robert Snow explore one of the most misunderstood topics in relationships: forgiveness. They revisit the subject with fresh insights, addressing common misconceptions, the crucial difference between forgiveness and reconciliation, and when it might actually be wise to move slowly on reconciliation — while still choosing internal peace.Through personal stories (including Sharla's transformational experience with ho'oponopono), real client examples, and science-backed research, you'll discover how forgiveness is something you do for yourself — not for the offender. Learn how to let go of resentment without losing your boundaries or compromising your safety.Whether you're working through a small rupture or a deep wound, this episode offers clarity, hope, and practical tools to help you find freedom.Key Takeaways:Forgiveness is an internal process — it does not mean forgetting, excusing, or reconciling.You can forgive someone and still maintain strong boundaries (or even choose not to reconcile).Your peace does not have to wait for the other person to change — that's living at cause.Unforgiveness carries real physical and mental health costs, but forgiveness offers powerful benefits.Resources Mentioned:Companion Episode: Ho'oponopono Forgiveness Meditation (available on Spotify & Apple Podcasts) and available here!Research & Further Reading:Toussaint, L. L., et al. (2016). “Forgiveness, Stress, and Health: A 5-Week Dynamic Parallel Process Study.” Annals of Behavioral Medicine. PubMed Abstract | Full Text (PMC)Toussaint, L. L., et al. (2016). “Effects of Lifetime Stress Exposure on Mental and Physical Health in Young Adulthood: How Stress Degrades and Forgiveness Protects Health.” Journal of Health Psychology. PubMed Abstract | PDFEnright's Process Model of Forgiveness: International Forgiveness InstituteConnect With Us:Website: masteryourmarriage.usSubscribe on your favorite podcast app and leave a 5-star review — it helps us reach more couples!Follow us on social media @MasterYourMarriage

On August 12, 1984, 13-year-old Eugene Wade Martin vanished while delivering newspapers in Des Moines, Iowa. Just two years earlier, another paperboy, Johnny Gosch, disappeared under eerily similar circumstances only miles away. Despite extensive investigations, countless theories, and decades of speculation, neither boy has ever been found. In Part One of The Paper Boy Abductions, I walk you through the mysterious disappearance of Eugene Martin, the haunting parallels to Johnny Gosch's case, and the questions that continue to surround two of Iowa's most infamous unsolved child disappearances.Anyone with information about Eugene Martin is asked to call Det. Jeff Shannon at the Des Moines Police Department at (515) 283-4864. You may also call Det. Larry Penland at (515) 237-1550.Connect with us on Social Media!You can find us at:Instagram: @bookofthedeadpodX: @bkofthedeadpodFacebook: The Book of the Dead PodcastTikTok: BookofthedeadpodOr visit our website at www.botdpod.comAlex, T. (1984, August 16). Branstad gives moral support to Martin family. The Des Moines Register, 15A.Alex, T. (2001, September 3). Officer who investigated missing carrier retires. The Des Moines Register, 2B.Beedle, D. (2020, September 15). Eugene Wade Martin. Find a Grave. https://www.findagrave.com/memorial/215645180/martinCOLD CASE SPOTLIGHT: Johnny Gosch. (2015, June 11). NBC News. https://www.nbcnews.com/feature/cold-case-spotlight/cold-case-spotlight-johnny-gosch-n234291D.M. police don't know where to search. (1984, August 19). The Des Moines Register, 1B-3B.EUGENE WADE MARTIN | Missing Person Information Clearinghouse. (n.d.). https://missingpersons.iowa.gov/divisions/criminal-investigation/missing-persons/eugene-wade-martinGene didn't run away. . .his birthday was coming. (1984, September 2). The Des Moines Register, 1A-7A.Iowa Cold Cases, Inc. (2026, March 28). Eugene Martin | Iowa Cold cases. Iowa Cold Cases. https://iowacoldcases.org/case-summaries/eugene-martin/Krenz, A. (2015, November 6). Eugene Martin case remains open after 31 years. weareiowa.com. https://www.weareiowa.com/article/news/local/eugene-martin-case-remains-open-after-31-years/524-02cb76a5-43bd-4297-af0d-5275df5aee9eMokrzycki, P. (2015). Lost in the Heartland: Childhood, Region, and Iowa's Missing Paperboys. Annals of Iowa, 74(1), 29–69. https://doi.org/10.17077/0003-4827.12170Santiago, F. (1997, August 27). Gosch lives, mom is told. The Des Moines Register, 2A.Santiago, F., & Alex, T. (1994, August 22). Private eye believes Martin disappearance was planned. The Des Moines Register, 2A.Sederstrom, J. (2024, August 22). Why don't missing kids appear on milk cartons anymore? Oxygen. https://www.oxygen.com/the-girl-on-the-milk-carton/crime-news/why-dont-missing-kids-appear-on-milk-cartons-anymoreShort, M. (2025, June 7). Eugene Martin: 1984 Disappearance of Iowa Paperboy Still Unsolved. Medium. https://medium.com/bizarre-unsolved-cases/eugene-martin-1984-disappearance-of-iowa-paperboy-still-unsolved-27d88991a6c1Smith, G. (1985, August 10). Eugene Martin case no closer to solution. The Cedar Rapids Gazette, 5A.Suk, T. (1990, March 27). D.M. officers follow Martin case to Mexico. The Des Moines Register, 9.Tauscheck, M. (2017, October 9). Eugene Martin's brother talks about hope case will be solved. KCCI. https://www.kcci.com/article/eugene-martin-s-brother-talks-about-hope-case-will-be-solved/6923136The Associated Press. (1985, February 10). Parents heat up search. Quad City Times, 8A.The disappearance of Eugene Martin. (2025, April 14). Crime and Coffee Couple. https://crimeandcoffeecouple.wordpress.com/2024/07/11/the-disappearance-of-eugene-martin/The National Missing and Unidentified Persons System (NAMUS). (n.d.). NamUs.gov. https://www.namus.gov/MissingPersons/Case#/6348?navVanBaale, K. W. (2025, September 22). The Legacy of the Paperboy Abductions | A&E. AETV. https://www.aetv.com/articles/paperboy-abductions-milk-cartonIf you enjoyed the episode, consider leaving a review or rating! It helps more than you know! If you have a case suggestion, or want attention brought to a loved one's case, email me at bookofthedeadpod@gmail.com with Case Suggestion in the subject line.Stay safe, stay curious, and stay vigilant.

A headline like “weight loss drugs may reduce breast cancer risk” grabs attention fast, but the real story lives in the fine print. We take you through a new Penn Medicine study that observed lower breast cancer rates among women with overweight or obesity who used GLP-1 medications, then we translate what that finding actually means in plain language. Observational data can reveal a signal worth studying, but it cannot prove the medication caused the outcome, and that distinction matters for your decisions and your expectations. We also zoom out to the bigger why: obesity is not just about body size. Fat tissue is biologically active, shaping chronic inflammation, estrogen exposure after menopause, insulin resistance, and even how well the immune system spots abnormal cells. Those pathways help explain why obesity is linked to many cancers, including postmenopausal breast cancer, and why researchers are curious whether effective obesity treatment could shift risk over time. Then we get practical. We review what stronger evidence from randomized controlled trials says so far: GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound do not appear to increase breast cancer risk in the available trial data, even though most trials were not designed to study cancer outcomes for many years. We also discuss why newer studies seem most suggestive for hormone receptor positive breast cancer, along with the leading theories: weight loss itself, improved metabolic health and insulin signaling, reduced inflammation, and the still-unclear possibility of direct GLP-1 effects in cancer biology. If you like evidence-based medicine with real-world context (and a little Philly-life banter), subscribe, share this episode with a friend, and leave a review so more people can find the show. What question do you want answered next about GLP-1s, obesity treatment, or cancer risk?ReferencesRisk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists : A Systematic Review and Meta-Analysis. Ko A, Chang YC, Bahar F, et al. Annals of Internal Medicine. 2025;. doi:10.7326/ANNALS-25-02237.Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-Analysis. Piccoli GF, Mesquita LA, Stein C, et al. The Journal of Clinical Endocrinology and Metabolism. 2021;106(3):912-921. doi:10.1210/clinem/dgaa891.Glucagon-Like Peptide 1 Receptor Agonists and Cancer Risk: The Good, the Bad and the Unknown. Mannucci E, Dicembrini I. Nature Reviews. Clinical Oncology. 2026;23(6):459-470. doi:10.1038/s41571-026-01135-0.GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women. McDonald ES, Gillis LB, Gabriel P, et al. JCO Oncology Practice. 2026;:101200OP2600485. doi:10.1200/OP-26-00485.GLP-1 therapy and hormone receptor–positive breast cancer risk and survival: A real-world analysis.. Shah Z, Hundal J, Afridi S, et al. Journal of Clinical Oncology. 2026;44(Suppl 16):10548. doi:10.1200/JCO.2026.44.16_suppl.10548.Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer. Tatum KL, Dahman B, Stevenson A, et al. JAMA Network Open. 2026;9(5):e2612133. doi:10.1001/jamanetworkopen.2026.12133.Association of Glucagon-Like Peptide-1 Receptor Agonists With Risk of Cancers-Evidence From a Drug Target Mendelian Randomization and Clinical Trials. Sun Y, Liu Y, Dian Y, et al. International Journal of Surgery (London, England). 2024;110(8):4688-4694. doi:10.1097/JS9.0000000000001514.GLP-1 receptor agonists and breast cancer risk in type 2 diabetes.. Guo Cheng and Amanda Ward. Journal of Clinical Oncology. 2025;43(Suppl 16):10557. doi:10.1200/JCO.2025.43.16_suppl.10557.Glucagon-Like Peptide-1 Analogues and Risk of Breast Cancer in Women With Type 2 Diabetes: Population Based Cohort Study Using the UK Clinical Practice Research Datalink. Hicks BM, Yin H, Yu OH, et al. BMJ (Clinical Research Ed.). 2016;355:i5340. doi:10.1136/bmj.i5340.GLP-1 Receptor Agonists and Cancer: Current Clinical Evidence and Translational Opportunities for Preclinical Research. Valencia-Rincón E, Rai R, Chandra V, Wellberg EA. The Journal of Clinical Investigation. 2025;135(21):e194743. doi:10.1172/JCI194743.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski

Listener discretion is advised!!! References: Gabayan, G. Z., Gould, M. K., Weiss, R. E., Patel, N., Donkor, K. A., Chiu, V. Y., Yiu, S. C., Jones, J. P., Hoffman, J. R., & Sarkisian, C. A. (2016). Poor Outcomes After Emergency Department Discharge of the Elderly: A Case-Control Study. Annals of Emergency Medicine, 68(1), 43–51.e2. Ganetsky M, Lopez G, Coreanu T, Novack V, Horng S, Shapiro NI, Bauer KA. Risk of Intracranial Hemorrhage in Ground-level Fall With Antiplatelet or Anticoagulant Agents. Acad Emerg Med. 2017 Oct;24(10):1258-1266. Gokhroo, R. K., Ranwa, B. L., Kishor, K., et al. (2015). Sweating: A Specific Predictor of ST‐Segment Elevation Myocardial Infarction Among the Symptoms of Acute Coronary Syndrome: Sweating In Myocardial Infarction (SWIMI) Study Group. Clinical Cardiology, 39, 90–95. Knack SKS, Scott N, Driver BE, Prekker ME, Black LP, Hopson C, Maruggi E, Kaus O, Tordsen W, Puskarich MA. Early Physician Gestalt Versus Usual Screening Tools for the Prediction of Sepsis in Critically Ill Emergency Patients. Ann Emerg Med. 2024 Sep;84(3) Koo, A. (Oct 29, 2024). Putting Clinical Gestalt to Work in the Emergency Department. Available: https://www.acepnow.com/article/putting-clinical-gestalt-to-work-in-the-emergency-department/5/?singlepage=1 Long, B., Keim, S. M., Gottlieb, M., Carlson, J., Bedolla, J., & Reisdorff, E. J. (2024). Can I Discharge This Adult Patient with Abnormal Vital Signs From the Emergency Department? The Journal of Emergency Medicine, 67(4), e487–e493. Milner, K. A., Funk, M., Arnold, A., & Vaccarino, V. (2002). Typical symptoms are predictive of acute coronary syndromes in women. American Heart Journal, 143, 283–288.

Welcome to this week's Midlife Minute. Today, I'm focusing on all the questions I received about gallbladder health, including HRT-provoking symptoms, supplements that improve gallbladder health, and evidence-based food interventions. IN THIS EPISODE, YOU WILL LEARN: Why the risk of gallstones and gallbladder inflammation increases during the menopause transition How estrogen and progesterone HRT have different effects on gallbladder functioning The differences in risk between transdermal and oral HRT How the progesterone in HRT can cause gallbladder issues in some women What TUDCA is, and how it supports gallbladder health The value of TUDCA for women who have had their gallbladders removed How various nutrients and supplements support bile flow and gallbladder health What can contribute to gallstone formation Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Gallbladder Research: Cabrera D, Arab JP, Arrese M. UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications. Seminars in Liver Disease. 2019;39(4):397–404. doi:10.1055/s-0039-1696799  Vang S, Longley K, Steer CJ, Low WC. The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases. Global Advances in Health and Medicine. 2014;3(3):58–69. doi:10.7453/gahmj.2014.017  Bai M, Yang L, Liao H, et al. Tauroursodeoxycholic acid improves nonalcoholic fatty liver disease by regulating gut microbiota and bile acid metabolism. Journal of Agricultural and Food Chemistry. 2024;72(41):22655–22668. doi:10.1021/acs.jafc.4c04630  Simon JA, Hudes ES. Relation of serum ascorbic acid to serum vitamin B12, serum ferritin, and kidney stones in US adults. *Archives of Internal Medicine.*1999;159(6):619–624. doi:10.1001/archinte.159.6.619  Walcher T, Haenle MM, Kron M, et al. Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population. BMC Gastroenterology. 2009;9:74. doi:10.1186/1471-230X-9-74  Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term intake of dietary fiber and decreased risk of cholecystectomy in women. American Journal of Gastroenterology. 2004;99(7):1364–1370. doi:10.1111/j.1572-0241.2004.30281.x  Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA, Giovannucci EL. Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology. 2002;123(6):1823–1830. doi:10.1053/gast.2002.37085  Moerman CJ, Smeets FW, Kromhout D. Dietary risk factors for clinically diagnosed gallstones in middle-aged men — a 25-year follow-up study. Annals of Epidemiology. 1994;4(3):248–254. doi:10.1016/1047-2797(94)90099-x Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma. Lipids in Health and Disease. 2024;23(1):82. doi:10.1186/s12944-024-02074-4  Pitt HA, Doty JE, Murphy MM, Schwarz MB. Progesterone alters biliary flow dynamics. Annals of Surgery. 1999;229(2):205–209. doi:10.1097/00000658-199902000-00008

The Enhanced Games, hosted in Las Vegas last Saturday, made a bold claim. With the use of performance-enhancing drugs, enhanced athletes would break not just personal records but world records.  And the end goal? To sell those same drugs to the masses.  It's arguably the biggest marketing stunt of the year so far, and today on Nudge I reveal the psychology behind it.  Did the Enhanced Games succeed? Listen to find out.  --- Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults Subscribe to my newsletter: https://www.nudgepodcast.com/mailing-list  Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/  --- Today's sources  Landy, D., & Sigall, H. (1974). Beauty is talent: Task evaluation as a function of the performer's physical attractiveness. Journal of Personality and Social Psychology, 29(3), 299–304. Miller, A. G. (1970). Role of physical attractiveness in impression formation. Psychonomic Science, 19(4), 241–242. Mujika, I., & Burke, L. M. (2019). Swimming fast when it counts: A 7-year analysis of Olympic and World Championships performance. International Journal of Sports Physiology and Performance. Nicolau, J. L., Mellinas, J. P., & Martín-Fuentes, E. (2020). The halo effect: A longitudinal approach. Annals of Tourism Research, 83, 102938. Nisbett, R. E., & Wilson, T. D. (1977). The halo effect: Evidence for unconscious alteration of judgments. Journal of Personality and Social Psychology, 35(4), 250–256.

Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPart 1: The Road of RhythmPart 1 focuses on the drum as an ancient technology of altered consciousness. The argument is not that every beat causes trance, or that neuroscience has proven spirits. The stronger argument is that rhythm enters the human organism through hearing, motor prediction, breath, movement, attention, emotion, expectation, culture, and social synchrony. The drum becomes powerful when sound, body, group, ritual frame, and meaning converge. These sources support the archaeology, neuroscience, EEG research, shamanic studies, possession studies, Indigenous and culturally specific drum traditions, ritual theory, placebo and meaning-response research, ceremonial magic, and modern witchcraft material used in the episode.Core Academic and Scientific SourcesHuels, Emma R., Hyoungkyu Kim, UnCheol Lee, Tirsa Bel-Bahar, Ana V. Colmenero, Alexandra Nelson, Stefanie Blain-Moraes, George A. Mashour, and Richard E. Harris. “Neural Correlates of the Shamanic State of Consciousness.” Frontiers in Human Neuroscience 15 (2021): 610466. Use for the strongest modern EEG anchor. This study used high-density EEG with shamanic practitioners and controls during rest, shamanic drumming, and classical music listening. It assessed altered-state reports alongside brain measures such as power, connectivity, signal diversity, and criticality. Use carefully: the study does not prove spirits or show that drumming mechanically causes trance in everyone. It supports the more careful claim that trained practitioners entering shamanic states with drumming show measurable brain-state differences.Gordon, Yoel, Golan Karvat, Noa Dagan, and Ayelet N. Landau. “Neural Tracking at Theta Predicts Drumming-Induced Altered States of Consciousness.” Scientific Reports 16, no. 1 (2026): Article 10204. Use for the strongest updated drumming/theta/neural-tracking source. This study tested drumming at theta, delta, and alpha-rate rhythms while recording EEG, and found that stronger rhythmic neural tracking at theta was linked to stronger altered-experience reports. Use carefully: this does not mean theta equals the spirit world or that one frequency opens a portal. The serious point is that altered experience may depend partly on how strongly the nervous system tracks rhythmic stimulation.Aparicio-Terrés, R., et al. “The Neurobiology of Altered States of Consciousness Induced by Drumming and Other Rhythmic Sound Patterns.” Annals of the New York Academy of Sciences, 2025. Use for the newer review literature showing that rhythmic sound is now a serious altered-consciousness research topic. This supports the opening claim that modern academia is examining drumming, rhythmic sound, absorption, relaxation, cognition, and neural activity without reducing the subject to one simple “trance frequency.” The review is especially useful for framing the field as promising but still complex.Neher, Andrew. “Auditory Driving Observed with Scalp Electrodes in Normal Subjects.” Electroencephalography and Clinical Neurophysiology 13 (1961): 449–451. Use for the historical bridge between repetitive sound, EEG, auditory driving, and early scientific interest in rhythmic stimulation.Neher, Andrew. “A Physiological Explanation of Unusual Behavior in Ceremonies Involving Drums.” Human Biology 34, no. 2 (1962): 151–160. Use carefully. This is useful as an early attempt to connect ceremonial drumming and physiology, but it should be balanced with Rouget because the “drum simply causes trance” argument is too mechanical.Maurer, R., V. K. Kumar, L. Woodside, and R. J. Pekala. “Phenomenological Experience in Response to Monotonous Drumming and Hypnotizability.” American Journal of Clinical Hypnosis 40, no. 2 (1997): 130–145. Use for monotonous drumming, subjective altered experience, imagery, absorption, and hypnotizability.Maxfield, Melinda C. “Effects of Rhythmic Drumming on EEG and Subjective Experience.” PhD diss., Institute of Transpersonal Psychology, 1990. Use as older supporting context on drumming, EEG, imagery, body-image changes, and subjective altered experience. Do not make this the main scientific proof; use it as background.Nozaradan, Sylvie, Isabelle Peretz, and André Mouraux. “Tagging the Neuronal Entrainment to Beat and Meter.” The Journal of Neuroscience 31, no. 28 (2011): 10234–10240. Use for EEG evidence that the brain can track beat and meter. This supports the claim that the brain does not merely hear rhythm as background sound; it can represent rhythmic structure in measurable ways.Nozaradan, Sylvie. “Exploring How Musical Rhythm Entrains Brain Activity with Electroencephalogram Frequency-Tagging.” Philosophical Transactions of the Royal Society B 369, no. 1658 (2014). Use as broader rhythm/EEG entrainment support. This helps explain frequency-tagging, beat tracking, meter, neural entrainment, and the measurable relationship between rhythmic structure and brain activity.Thaut, Michael H., Gerald C. McIntosh, and Volker Hoemberg. “Neurobiological Foundations of Neurologic Music Therapy: Rhythmic Entrainment and the Motor System.” Frontiers in Psychology 5 (2015). Use for rhythm as motor-system timing information. This supports the claim that a beat can become bodily instruction, not just sound for the ear. Especially useful when discussing rhythmic auditory stimulation, motor planning, gait, entrainment, and the auditory-motor bridge.Ross, Jessica M., John R. Iversen, and Ramesh Balasubramaniam. “Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction.” 2022. Use for rhythm, timing, prediction, sensorimotor entrainment, and the way musical rhythm interacts with time perception.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960. Use for synchrony and social bonding. This helps support the group-body argument: moving or acting in time with others can increase affiliation.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5. Use for the claim that synchronized movement can increase cooperation and attachment among participants.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096. Use for music, synchrony, bonding, endorphin/social mechanisms, and why group rhythm can feel like more than private listening.Fancourt, Daisy, Rosie Perkins, Sara Ascenso, Louise Atkins, Fatima Kilfeather, and Aaron Williamon. “Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users.” PLOS ONE 11, no. 3 (2016): e0151136. Use for modern group-drumming research showing psychological and physiological effects, including anxiety, depression, social resilience, wellbeing, and inflammatory immune response. Use carefully: this does not make group drumming a cure-all. It supports the more grounded claim that embodied rhythm and group participation can affect mood, social connection, and body chemistry.Bittman, Barry B., et al. “Composite Effects of Group Drumming Music Therapy on Modulation of Neuroendocrine-Immune Parameters in Normal Subjects.” Alternative Therapies in Health and Medicine 7, no. 1 (2001): 38–47. Use as older supporting material on group drumming and neuroendocrine-immune measures. Keep secondary. Fancourt is cleaner for the main script body.Archaeology and Deep History of DrumsLawergren, Bo. “Neolithic Drums in China.” In Music Archaeology in China. 2006. Use for clay drums in Neolithic China and the deep-history claim that drums are not just poetic symbols of antiquity. They appear in the archaeological record as instruments tied to early sound-making, ceremony, and social order.Both, Arnd Adje. “Music Archaeology: Some Methodological and Theoretical Considerations.” Use as general support for why ancient instruments should be treated as ritual and social evidence, not merely decorative objects.Anthropology, Ethnomusicology, Ritual, and TranceRouget, Gilbert. Music and Trance: A Theory of the Relations Between Music and Possession. Translated by Brunhilde Biebuyck. Chicago: University of Chicago Press, 1985. Essential source. Use for the caution that music does not mechanically or universally cause trance. Rouget helps keep the argument academically serious by emphasizing culture, ritual frame, meaning, and expectation.Becker, Judith. Deep Listeners: MAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Listener discretion is advised! References: Buttner & Arlanger. (May 3, 2022). ST depression does not localise. Available: https://litfl.com/st-depression-does-not-localise/ Cannon, J. W., Khan, M. A., Raja, A. S., et al. (2017). Damage control resuscitation in patients with severe traumatic hemorrhage. Journal of Trauma and Acute Care Surgery, 82, 605-617. Kabra, R., Acharya, S., Kamat, S., & Kumar, S. (2022). ST-Segment Elevation in Lead aVR With Global ST-Segment Depression: Never Neglect Left Main Coronary Artery (LMCA) Occlusion. Cureus. Lee, G.-K., Hsieh, Y.-P., Hsu, S.-W., Lan, S.-J., & Soni, K. (2019). Value of ST‐segment change in lead aVR in diagnosing left main disease in Non‐ST‐elevation acute coronary syndrome—A meta‐analysis. Annals of Noninvasive Electrocardiology, 24. Morrison, C. A., Carrick, M. M., Norman, M. A., et al. (2011). Hypotensive Resuscitation Strategy Reduces Transfusion Requirements and Severe Postoperative Coagulopathy in Trauma Patients With Hemorrhagic Shock: Preliminary Results of a Randomized Controlled Trial. Journal of Trauma: Injury, Infection & Critical Care, 70, 652-663. Rossaint, R., Afshari, A., Bouillon, B., et al. (2023). The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Critical Care, 27. Tamura, A. (2014). Significance of lead aVR in acute coronary syndrome. World Journal of Cardiology, 6(7), 630. Uthamalingam, S., Zheng, H., Leavitt, M., Pomerantsev, E., Ahmado, I., Gurm, G. S., & Gewirtz, H. (2011). Exercise-Induced ST-Segment Elevation in ECG Lead aVR Is a Useful Indicator of Significant Left Main or Ostial LAD Coronary Artery Stenosis. JACC: Cardiovascular Imaging, 4, 176–186. Weymouth, W., Long, B., Koyfman, A., & Winckler, C. (2019). Whole Blood in Trauma: A Review for Emergency Clinicians. The Journal of Emergency Medicine, 56, 491-498. Wang, A., Singh, V., Duan, Y., Su, X., Su, H., Zhang, M., & Cao, Y. (2020). Prognostic implications of ST‐segment elevation in lead aVR in patients with acute coronary syndrome: A meta‐analysis. Annals of Noninvasive Electrocardiology, 26.

A life-long treatment for high LDL, a VESALIUS subanalysis, tirzepatide beats semaglutide again, arrhythmia burden in cardiac amyloidosis, and a lipid guideline rebuttal are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Permanent Lipid Lowering therapy Verve 102 Therapy for FH https://www.nejm.org/doi/full/10.1056/NEJMoa2601283 II Vesalius Substudy on PCSK9i Use in Patients With Previous PCI VESALIUS Subgroup Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080616 VESALIUS Study - NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2514428 III Tirzepatide looking to be best again SURPASS-EARLY Trial https://www.acpjournals.org/doi/10.7326/ANNALS-25-05602 SURMOUNT-5 Trial https://www.nejm.org/doi/abs/10.1056/NEJMoa2416394 IV Arrhythmias in Cardiac Amyloidosis Loop Recorders Reveal Arrhythmias in Cardiac Amyloidosis https://www.medscape.com/viewarticle/loop-recorders-reveal-arrhythmias-cardiac-amyloidosis-2026a1000gq9 EXCALIBUR Study https://www.jacc.org/doi/10.1016/j.jacc.2026.04.030 V Lipid Guidelines ·       In Defense of the 2026 Dyslipidemia Guideline https://www.medscape.com/viewarticle/defense-2026-dyslipidemia-guideline-2026a1000hd0 Lipid Guidelines: Four Major Concerns https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Every standout book has one thing in common: a strong editorial process behind it.  In this episode of “Inside Independent Publishing (with IBPA),” the Editorial Freelancers Association's Director of Professional Development Asher Rose Fox demystifies what it really takes for independent publishers, author-publishers, and authors to transform a manuscript into a market-ready book—covering every stage of editing, what you can expect to invest, and how to collaborate effectively with editors. If you're serious about publishing a book that readers—and reviewers—take seriously; this is an episode you can't afford to miss. PARTICIPANTS Asher Rose Fox (they/them) has been an editor and activist for over 30 years. A longtime member of the Editorial Freelancers Association, Asher is proud to serve the freelance editing community as the EFA's Director of Professional Development. They've held staff editorial roles at Publishers Weekly, About.com, PCMag, and The Annals of Improbable Research; freelanced for innumerable clients, including Strange Horizons, Popular Mechanics, nonsense nyc, Anesthesiology News, and many individual authors; and volunteered with 10%+, Common Cause, the League of Women Voters, Arisia, Readercon, and Kolot Chayeinu/Voices of Our Lives. Asher has also co-edited the groundbreaking and award-shortlisted anthology Long Hidden, delighted Twitter as GRAMMARHULK, and played a human aerodrome for paper airplanes at the Ig Nobel Awards. They make things better. Independent Book Publishers Association is the largest trade association for independent publishers in the United States. As the IBPA Director of Membership & Member Services, Christopher Locke assists the 4,000 members as they travel along their publishing journeys. Major projects include managing the member benefits to curate the most advantageous services for independent publishers and author publishers; managing the Innovative Voices Program that supports publishers from marginalized communities; and hosting the IBPA podcast, “Inside Independent Publishing (with IBPA).” He's also passionate about indie publishing, because he's an author publisher himself, having published two novels so far in his YA trilogy, The Enlightenment Adventures. LINKS Learn more about the Editorial Freelancers Association at https://www.the-efa.org/ Follow the EFA on: Facebook - https://www.facebook.com/EFAFreelancers Instagram - https://www.instagram.com/efafreelancers/ Bluesky - https://bsky.app/profile/efafreelancers.bsky.social YouTube - https://www.youtube.com/@efa1970/featured?themeRefresh=1 LinkedIn - https://www.linkedin.com/company/efafreelancers/ Follow IBPA on: Facebook – https://www.facebook.com/IBPAonline Instagram - https://www.instagram.com/ibpalovesindies/ LinkedIn: https://www.linkedin.com/company/independent-book-publishers-association This episode is presented by Friesens Corporation. Learn more at https://www.friesens.com/

In this episode, I'm breaking down the four pillars of recomposition to help you shrink your body fat, build lean muscle, and reclaim the energy you had in your 20s. For 30 years, the fitness world has preached the same rule: you have to "bulk" to gain muscle, or "cut" to lose fat. But modern science shows us a different path. It is entirely possible to do both at the same time through a process called Body Recomposition. Sponsors: Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: ⁠⁠⁠https://www.youtube.com/@drjoshaxe?sub_confirmation=1⁠⁠⁠ 

This week we pull out The Secret Language of Birthdays from the 90s and read off personality breakdowns and find out which celebrities were born on the same date, plus some love for Broadway's Bob Fosse and how he changed theater and dance. Erin discusses the 5th Circuit Court of Appeals reinstated restrictions on Mifepristone, and how the Supreme Court temporarily restored access to the drug via mail until May 11, 2026. Bryan discusses a study published in Annals of Tourism Research showing how queer men of color from London feel sexier and more noticed on dating apps while on vacation, plus how St. George, Utah has to pay the legal fees for a group of drag queens who sued for being denied a permit for an all-ages drag show in a public park. For all our bonus content and video episodes visit patreon.com/attitudes

What if loneliness isn't just an emotion… but one of the most dangerous biological threats to your health? In this deeply personal and scientifically explosive solo episode, Darin opens up about something he recently realized in his own life: despite being surrounded by people, he was lonely. But what began as an emotional realization quickly became a deep dive into some of the most shocking research he's ever uncovered, showing that chronic loneliness may increase the risk of heart disease, dementia, cancer, autoimmune dysfunction, accelerated aging, and early death. From inflammatory gene expression and cortisol dysregulation to oxytocin, vulnerability, and the collapse of real human connection in the digital age, this episode reveals why loneliness may be the most overlooked "fatal convenience" of modern life, and how vulnerability may be the medicine. What You'll Learn Why loneliness is a biological crisis, not just an emotional feeling The shocking link between loneliness and heart disease, dementia, and early death Why the quality of your relationships is the #1 predictor of long-term health How loneliness activates inflammatory genes inside your body The role of cortisol, sleep disruption, and chronic stress in social isolation Why social media and "surface-level connection" are replacing real intimacy The connection between loneliness and Alzheimer's disease How oxytocin and genuine connection reduce inflammation Why vulnerability is the gateway to meaningful relationships Practical ways to create deeper connection starting today Chapters 00:00:33 – Sponsor: the truth about the exploding NAD supplement market 00:01:04 – Why supplement verification and transparency matter 00:02:17 – Opening: Darin admits something deeply personal 00:02:30 – "I realized recently… I'm lonely" 00:02:37 – The difference between being surrounded by people vs being truly known 00:03:06 – Loneliness as a biological experience, not just an emotional one 00:03:27 – The hidden risks: heart disease, dementia, cancer, early death 00:03:45 – Why this is not fringe science 00:04:13 – The most important predictor of long-term health 00:04:34 – Why relationship QUALITY matters more than quantity 00:05:06 – The global loneliness epidemic 00:05:11 – U.S. Surgeon General advisory on loneliness 00:05:39 – Loneliness declared a public health crisis 00:06:02 – 50% of Americans report measurable loneliness 00:06:22 – "A generational collapse of connection" 00:06:30 – 29% of adults have no close friends 00:06:40 – Face-to-face interactions dramatically declining 00:07:01 – The UK, Japan, and Australia loneliness crisis initiatives 00:07:32 – The paradox: hyperconnected but deeply isolated 00:08:04 – Loneliness as a biological alarm signal 00:08:31 – What loneliness actually looks like in modern life 00:08:42 – The lonely CEO, the unseen mother, the isolated social media addict 00:09:31 – "Perceived social isolation" and why the brain can't tell the difference 00:10:21 – Meta-analysis of 3.4 million people 00:10:55 – Loneliness vs obesity and smoking risk comparisons 00:11:18 – The biology of loneliness begins 00:11:50 – NF-kB: inflammatory gene activation explained 00:12:33 – How loneliness changes gene expression 00:13:02 – Chronic inflammation and disease pathways 00:13:21 – Cortisol, sleep disruption, and immune dysfunction 00:14:00 – How loneliness affects brain repair and amyloid plaque clearing 00:14:21 – Sponsor: Fatty15 and cellular health 00:18:02 – The Alzheimer's and dementia connection 00:18:25 – Loneliness as a major modifiable dementia risk factor 00:18:57 – Cortisol, neuroinflammation, and brain degeneration 00:19:16 – The hippocampus physically shrinking in lonely people 00:19:27 – Social media as a "fatal convenience" 00:19:57 – The oxytocin economy: connection as medicine 00:20:15 – Oxytocin as one of the body's strongest anti-inflammatory molecules 00:20:30 – HeartMath research: emotional synchronization between people 00:20:48 – "You regulate each other's biology" 00:21:07 – The real barrier: vulnerability 00:21:32 – Darin's recent experiences with radical vulnerability 00:21:54 – Conversations with family, ex-partners, and loved ones 00:22:35 – Brené Brown's research on connection and worthiness 00:23:14 – The "depth audit" exercise 00:23:42 – Reaching out, expressing appreciation, and owning your emotions 00:24:01 – Sacred hours: spending time without phones 00:24:13 – Questions that create real intimacy 00:24:30 – Darin's emotional conversation with his brother 00:25:03 – Protecting yourself from social media disconnection 00:25:20 – Becoming a source of joy and connection in everyday life 00:25:25 – Darin reflects on seven years of subtle loneliness 00:25:48 – The shift from surface conversations to meaningful connection 00:26:01 – "If you want love, give love" 00:26:19 – Final message: generate the connection you want to receive 00:26:22 – Closing thoughts and outro Thank You to Our Sponsors Truniagen: Go to www.truniagen.com and use code DARIN20 at checkout for 20% off Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Loneliness isn't weakness. It isn't failure. It's a biological signal telling you that something essential is missing. And in a world addicted to surface-level connection, the real medicine may simply be this: vulnerability, presence, eye contact, honesty, and the courage to let yourself truly be seen." Bibliography/Sources The Loneliness Epidemic & Public Health Data Bureau of Labor Statistics. (2023). American time use survey. U.S. Department of Labor. https://www.bls.gov/tus/ Cigna. (2023). Cigna U.S. loneliness index. Evernorth Health Services. https://newsroom.cigna.com/loneliness-epidemic-continues-to-rise-cigna-study Murthy, V. H. (2023). Our epidemic of loneliness and isolation: The U.S. Surgeon General's advisory on the healing effects of social connection and community. U.S. Department of Health and Human Services. https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf Survey Center on American Life. (2021). The state of American friendship: Change, challenges, and loss. American Enterprise Institute. https://www.americansurveycenter.org/research/the-state-of-american-friendship-change-challenges-and-loss/ Mortality & Systemic Health Risk Cohen, S., Doyle, W. J., Skoner, D. P., Rabin, B. S., & Gwaltney, J. M. (1997). Social ties and susceptibility to the common cold. JAMA, 277(24), 1940–1944. https://pubmed.ncbi.nlm.nih.gov/9200634/ Hawkley, L. C., & Cacioppo, J. T. (2010). Loneliness matters: A theoretical and empirical review of consequences and mechanisms. Annals of Behavioral Medicine, 40(2), 218–227. https://pubmed.ncbi.nlm.nih.gov/20396846/ Holt-Lunstad, J., Smith, T. B., Baker, M., Harris, T., & Stephenson, D. (2015). Loneliness and social isolation as risk factors for mortality: A meta-analytic review. Perspectives on Psychological Science, 10(2), 227–237. https://doi.org/10.1177/1745691614568352 Valtorta, N. K., Kanaan, M., Gilbody, S., Ronzi, S., & Hanratty, B. (2016). Loneliness and social isolation as risk factors for coronary heart disease and stroke. Heart, 102(13), 1009–1016. https://heart.bmj.com/content/102/13/1009 Genetics, Inflammation & The Immune System Cole, S. W. (2013). Social regulation of human gene expression: Mechanisms and implications for public health. American Journal of Public Health, 103(S1), S84–S92. https://pmc.ncbi.nlm.nih.gov/articles/PMC3786756/ Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007). Social regulation of gene expression in human leukocytes. Genome Biology, 8(9), Article R189. https://pmc.ncbi.nlm.nih.gov/articles/PMC2375027/ Sleep & Cognitive Decline Cacioppo, J. T., Hawkley, L. C., Berntson, G. G., Ernst, J. M., Gibbs, A. C., Stickgold, R., & Hobson, J. A. (2002). Do lonely days invade the nights? Potential social modulation of sleep efficiency. Psychological Science, 13(4), 384–387. https://pubmed.ncbi.nlm.nih.gov/12137144/ Holwerda, T. J., Deeg, D. J. H., Beekman, A. T. F., et al. (2014). Feelings of loneliness, but not social isolation, predict dementia onset. Journal of Neurology, Neurosurgery & Psychiatry, 85(2), 135–142. https://jnnp.bmj.com/content/85/2/135 Oxytocin & The Biology of Connection Szeto, A., Sun-Suslow, N., Mendez, A. J., Hernandez, R. I., Wagner, K. V., & McCabe, P. M. (2017). Regulation of the macrophage oxytocin receptor in response to inflammation. American Journal of Physiology—Endocrinology and Metabolism, 312(2), E183–E189. https://journals.physiology.org/doi/full/10.1152/ajpendo.00424.2016 Uvnas-Moberg, K. (2003). The oxytocin factor: Tapping the hormone of calm, love, and healing. Da Capo Press. https://books.google.com/books?id=b-aKjQoB_nQC Psychology, Vulnerability & Relationship Science Aron, A., Melinat, E., Aron, E. N., Vallone, R. D., & Bator, R. J. (1997). The experimental generation of interpersonal closeness. Personality and Social Psychology Bulletin, 23(4), 363–377. https://doi.org/10.1177/0146167297234003 Brown, B. (2010). The gifts of imperfection: Let go of who you think you're supposed to be and embrace who you are. Hazelden Publishing. https://brenebrown.com/book/the-gifts-of-imperfection/ Cacioppo, J. T., & Patrick, W. (2008). Loneliness: Human nature and the need for social connection. W. W. Norton & Company. https://wwnorton.com/books/9780393335286 Dunbar, R. I. M. (2012). Bridging evolutionary approaches to the social brain and social bonding. In F. B. M. de Waal & P. F. Ferrari (Eds.), The primate mind. Harvard University Press. https://www.hup.harvard.edu/books/9780674063104 Dunbar, R. I. M. (2021). Friends: Understanding the power of our most important relationships. Little, Brown and Company. https://www.hachettebookgroup.com/titles/robin-dunbar/friends/9781408711736/ Waldinger, R., & Schulz, M. (2023). The good life: Lessons from the world's longest scientific study on happiness. Simon & Schuster. https://www.simonandschuster.com/books/The-Good-Life/Robert-Waldinger/9781982166694

Braid is known for his work in hypnotism. But he was also a surgeon with a reputation for pioneering new treatments before he became fascinated with the scientific underpinnings of mesmerism. Research: Braid, James, and Arthur Edward Waite, ed. “Braid on hypnotism. Neurypnology; or, The rationale of nervous sleep considered in relation to animal magnetism or mesmerism and illustrated by numerous cases of its successful application in the relief and cure of disease.” London. George Redway. 1899. https://archive.org/details/braidonhypnotism00brai/page/n7/mode/2up “Clubfoot.” Cleveland Clinic. July 6, 2023. https://my.clevelandclinic.org/health/diseases/16889-clubfoot Crabtree A. “1784: The Marquis de Puységur and the psychological turn in the west.” J Hist Behav Sci.2019;55:199–215. https://doi.org/10.1002/jhbs.21974 Fletcher, George. “James Braid Of Manchester.” The British Medical Journal, vol. 2, no. 3590, 1929, pp. 776–77. JSTOR, http://www.jstor.org/stable/25334090 Hull, Clark L. “Hypnotism in Scientific Perspective.” The Scientific Monthly, vol. 29, no. 2, 1929, pp. 154–62. JSTOR, http://www.jstor.org/stable/14677 “Hypnotism.” Yorkville Enquirer. Feb. 23, 1860. https://www.newspapers.com/image/339341468/?match=1&terms=James%20Braid Lafontaine’s Third Conversazione on Mesmerism.” The Manchester Times and Manchester and Salford Advertiser and Chronicle. Nov. 20, 1841. https://www.newspapers.com/image/406088965/?match=1&terms=lafontaine Loudon, I. “Why are (male) surgeons still addressed as Mr?.” BMJ (Clinical research ed.) 321,7276 (2000): 1589-91. doi:10.1136/bmj.321.7276.1589 Macklis, R M. “Magnetic healing, quackery, and the debate about the health effects of electromagnetic fields.” Annals of internal medicine 118,5 (1993): 376-83. doi:10.7326/0003-4819-118-5-199303010-00009 Martin, Christy. “Mesmerized.” Science History Institute. Dec. 6, 2011. https://www.sciencehistory.org/stories/magazine/mesmerized/ Bramwell, J. Milne. “Hypnotism and treatment by suggestion.” New York. Da Capo Press. 1982. Accessed online: https://archive.org/details/hypnotismandtre00bramgoog/page/n6/mode/1up Rouse, Tyler. “The brief and strange history of mesmerism and surgery.” Hektoen International. Winter 2019. https://hekint.org/2018/12/24/the-brief-and-strange-history-of-mesmerism-and-surgery/ Sandby, George. “Mesmerism and its opponents.” London. Longman, Brown, Green and Longmans. 1848. https://archive.org/details/mesmerismandits01sandgoog “Sudden Death of Mr. James Braid, Surgeon.” The Guardian. March 26, 1860. https://www.newspapers.com/image/257847287/?match=1&terms=James%20Braid Weidow, Brandy, M.S. “James Braid.” Ebsco. 2024. https://www.ebsco.com/research-starters/health-and-medicine/james-braid Yeates, Lindsay Bertram. “James Braid: Surgeon, Gentleman Scientist, and Hypnotist.” University of New South Wales, Sydney. 2013. https://unsworks.unsw.edu.au/entities/publication/7573cb34-ceb9-41bb-a8b1-0951e93fdd10 See omnystudio.com/listener for privacy information.