Podcasts about myopathy

Nutritionist Leyla Muedin discusses research showing simple strength tests—grip strength and a five-rep sit-to-stand chair test—predict longevity in older women. In a University at Buffalo study of over 5,000 women ages 63–99 followed for eight years, stronger grip and faster chair-stand times were linked to lower mortality; every additional 7 kg of grip strength corresponded to a 12% reduction in death risk, and faster chair-stands were also associated with improved survival, even after adjusting for activity, cardiovascular fitness, and inflammation. She emphasizes prioritizing muscle-strengthening alongside aerobic exercise and suggests accessible resistance options (weights, bodyweight moves, or household items) with professional guidance as needed. She then cites UK Biobank data linking long-term statin use to declines in grip strength and appendicular lean mass, urging discussion with physicians and added vigilance, especially for those also using GLP-1 drugs that may reduce protein intake and muscle mass.

Cutaneous findings in statin-induced necrotizing myopathy [article]ACD to diabetes devices (part 1) [article]Trichophyton indotineae - use itraconazole! [article]Eosinophilic pustular folliculitis in infants [article]Green beans for diaper rash in the NICU [article]Confocal in kids [article] Trichophyton indotineae laboratory resources:Fungus Testing Laboratory — UT Health San AntonioCenter for Medical Mycology — University Hospitals Cleveland Medical CenterMycology Laboratory — Wadsworth Center, NYS Department of HealthBako Diagnostics (BakoDx)Check out Luke's Urticaria CME experience! aaaaicsu.gathered.com/invite/KQe1wPZbJY Learn more about the U of U Dermatology ECHO model! physicians.utah.edu/echo/dermatology-primarycare Want to donate to the cause? Do so here!Donate to the podcast: ⁠uofuhealth.org/dermasphere⁠Check out our video content on YouTube:⁠www.youtube.com/@dermaspherepodcast⁠and VuMedi!: ⁠www.vumedi.com/channel/dermasphere/⁠The University of Utah's DermatologyECHO: ⁠⁠physicians.utah.edu/echo/dermatology-primarycare⁠ Connect with us!- Web: ⁠⁠dermaspherepodcast.com/⁠⁠ - Twitter: @⁠DermaspherePC⁠- Instagram: dermaspherepodcast- Facebook: ⁠www.facebook.com/DermaspherePodcast/⁠- Check out Luke and Michelle's other podcast, SkinCast! ⁠⁠healthcare.utah.edu/dermatology/skincast/⁠⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at:- ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge)- ⁠⁠www.levelex.com/games/top-derm⁠⁠ (A free dermatology game to learn more dermatology!

Leyla Muedin, a registered dietitian nutritionist, discusses a UK Biobank analysis published in the Journal of Cachexia, “Sarcopenia and Muscle” (Nov 2025) linking continuous long-term statin use (e.g., Lipitor, Zocor, Crestor) to accelerated declines in grip strength and appendicular lean mass compared with never-users. Among 35,557 with follow-up data, grip strength declined by a mean 0.315 kg/year and appendicular lean mass by 0.057 kg/year in statin users; findings persisted after adjustment for age, sex, BMI, comorbidities, and a pharmacogenomic statin-response score. Leyla notes possible mechanisms (CoQ10/mevalonate pathway effects, mitochondrial dysfunction, apoptosis, calcium disruption, insulin resistance) and advises monitoring musculoskeletal health, supporting diet and regular physical activity, while not interpreting results as a reason to stop prescribing statins.

To have Dr. Morse answer a question, visit: https://drmorses.tv/ask/   00:00:00 - Intro - Books 00:02:42 - Skinny - Malabsorption - Autism 00:35:45 - Necrotizing Myopathy 00:49:23 - Acid Reflux - Anxiety - No Energy - Obese - Acne  01:10:28 - Difficulty Breathing - Lack of Smell - Brain Fog - Fatigue - HSV-2 - Scoliosis 01:35:28 - Weight 01:59:45 - Tooth Cavities 02:09:57 - Type 1 Diabetes 02:23:07 - Autistic - Giardia 02:41:57 - Grade 2 Varicocele 00:02:42 - Skinny - Malabsorption - Autism My son is 4 years old and he's never spoken a word in his life.  00:35:45 - Necrotizing Myopathy I wasn't mindful of my diet and was taking whey protein and waxy maize supplements, to build muscle.  00:49:23 - Acid Reflux - Anxiety - No Energy - Obese - Acne I know all raw fruit is the only way forward, but I was hoping for some pointers to ease the detox symptoms.  01:10:28 - Difficulty Breathing - Lack of Smell - Brain Fog - Fatigue - HSV-2 - Scoliosis Can't seem to find joy in anything anymore and don't feel like myself. 01:35:28 - Weight I don't understand why it's so difficult for me to keep the weight down.  01:59:45 - Tooth Cavities My saliva pH is alkaline, but my kidneys aren't filtering. 02:09:57 - Type 1 Diabetes Have you ever completely cured a Type 1 Diabetes patient with a purely fruit-based diet? 02:23:07 - Autistic - Giardia He has declined so much so that he won't really chew food, so I have to blend everything he eats. 02:41:57 - Grade 2 Varicocele The allopathic doctors have of course told me to get surgery.

While genetic testing has replaced muscle biopsy in the diagnosis of many genetic myopathies, clinical assessment and the integration of clinical and laboratory findings remain key elements for the diagnosis and treatment of muscle diseases. In this episode, Casey Albin, MD, speaks with Margherita Milone, MD, PhD, FAAN, FANA, author of the article “A Pattern Recognition Approach to Myopathy” in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Milone is a professor of neurology and the director of the Muscle Pathology Laboratory at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. Additional Resources Read the article: A Pattern Recognition Approach to Myopathy Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello, this is Dr Casey Albin. Today I'm interviewing Dr Margherita Milone on her article on a pattern recognition approach to myopathy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Welcome to the podcast, Dr Milone. Thank you so much for joining us. I'll start off by having you introduce yourself to our listeners. Dr Milone: Hello Casey, thank you so much for this interview and for bringing the attention to the article on muscle diseases. So, I'm Margherita Milone. I'm one of the neuromuscular neurologists at Mayo Clinic in Rochester. I have been interested in muscle disorders since I was a neurology resident many years ago. Muscle diseases are the focus of my clinical practice and research interest. Dr Albin: Wonderful. Thank you so much. When I think about myopathies, I generally tend to think of three large buckets: the genetic myopathy, the inflammatory myopathies, and then the necrotizing myopathies. Is that a reasonable approach to conceptualizing these myopathies? Dr Milone: Yeah, the ideology of the myopathies can be quite broad. And yes, we have a large group of genetic muscle diseases, which are the most common. And then we have immune-mediated muscle diseases, which include inflammatory myopathies as well as some form of necrotizing myopathies. Then we have some metabolic myopathies, which could be acquired or could be genetic. And then there are muscle diseases that are due to toxins as well as to infection. Dr Albin: Wow. So, lots of different etiologies. And that really struck me about your article, is that these can present in really heterogeneous ways, and some of them don't really read the rule book. So, we have to have a really high level of suspicion, for someone who's coming in with weakness, to remember to think about a myopathy. One of the things that I like to do is try to take us through a little bit of a case to sort of walk us through how you would approach if someone comes in. So, let's say you get, you know, a forty-year-old woman, and she's presenting with several months of progressive weakness. And she says that even recently she's noted just a little bit of difficulty swallowing. It feels to her like things are getting stuck. What are some of the things when you are approaching the history that would help you tease this to a myopathy instead of so many other things that can cause a patient to be weak? Dr Milone: Yes. So, as you mentioned, people who have a muscle disease have the muscle weakness often, but the muscle weakness is not just specific for a muscle disease. Because you can have a mass weakness in somebody who has a neurogenic paralysis. The problem with diagnosis of muscle diseases is that patients with these disorders have a limited number of symptom and sign that does not match the large heterogeneity of the etiology. So, in someone who has weakness, that weakness could represent a muscle disease, could represent an anterior horn cell disease, could represent a defect of neuromuscular junction. The clinical history of weakness is not sufficient by itself to make you think about a muscle disease. You have to keep that in the differential diagnosis. But your examination will help in corroborating your suspicion of a muscle disease. Let's say if you have a patient, the patient that you described, with six months' history of progressive weakness, dysphagia, and that patient has normal reflexes, and the patient has no clinical evidence for muscle fatigability and no sensory loss, then the probability that that patient has a myopathy increases. Dr Albin: Ah, that's really helpful. I'm hearing a lot of it is actually the lack of other findings. In some ways it's asking, you know, have you experienced numbness and tingling? And if not, that's sort of eliminating that this might not be a neuropathy problem. And then again, that fatigability- obviously fatigability is not specific to a neuromuscular junction, but knowing that is a hallmark of myasthenia, the most common of neuromuscular disorders. Getting that off the table helps you say, okay, well, it's not a neuromuscular junction problem, perhaps. Now we have to think more about, is this a muscle problem itself? Are there any patterns that the patients describe? I have difficulty getting up from a chair, or I have difficulty brushing my hair. When I think of myopathies, I historically have thought of, sort of, more proximal weakness. Is that always true, or not so much? Dr Milone: Yeah. So, there are muscle diseases that involve predominantly proximal weakness. For example, the patient you mentioned earlier could have, for example, an autoimmune muscle disease, a necrotizing autoimmune myopathy; could have, perhaps, dermatomyositis if there are skin changes. But a patient with muscle disease can also present with a different pattern of weakness. So, myopathies can lead to this weakness, and foot drop myopathies can cause- can manifest with the weakness of the calf muscles. So, you may have a patient presenting to the clinic who has no the inability to stand on tiptoes, or you may have a patient who has just facial weakness, who has noted the difficulty sealing their lips on the glasses when they drink and experiencing some drooling in that setting, plus some hand weakness. So, the muscle involved in muscle diseases can vary depending on the underlying cause of the muscle disease. Dr Albin: That's really helpful. So, it really is really keeping an open mind and looking for some supporting features, whether it's bulbar involvement, extraocular eye muscle involvement; looking, you know, is it proximal, is it distal? And then remembering that any of those patterns can also be a muscle problem, even if sometimes we think of distal being more neuropathy and proximal myopathy. Really, there's a host of ranges for this. I really took that away from your article. This is, unfortunately, not just a neat way to box these. We really have to have that broad differential. Let me ask another question about your history. How often do you find that patients complain of, sort of, muscular cramping or muscle pain? And does that help you in terms of deciding what type of myopathy they may have? Dr Milone: Many patients with muscle disease have muscle pain. The muscle pain could signal a presence of inflammation in skeletal muscle, could be the result of overuse from a muscle that is not functioning normally. People who have myotonia experience muscle stiffness and muscle pain. Patients who have a metabolic myopathy usually have exercise-induced muscle pain. But, as we know, muscle pain is also very nonspecific, so we have to try to find out from the patient in what setting the pain specifically occurs. Dr Albin: That's really helpful. So, it's asking a little bit more details about the type of cramping that they have, the type of pain they may be experiencing, to help you refine that differential. Similarly, one of the things that I historically have always associated with myopathies is an elevation in the CK, or the creatinine kinase. How sensitive and specific is that, and how do you as the expert sort of take into account, you know, what their CK may be? Dr Milone: So, this is a very good point. And the elevation of creatine kinase can provide a clue that the patient has a muscle disease, but it is nonspecific for muscle disease because we know that elevation of creatine kinase can occur in the setting of a neurogenic process. For example, we can see elevation of the creatine kinase in patients who have ALS or in patients who have spinal muscular atrophy. And in these patients---for example, those with spinal muscular atrophy---the CK elevation can be also of significantly elevated up to a couple of thousand. Conversely, we can have muscle diseases where the CK elevation does not occur. Examples of these are some genetic muscle disease, but also some acquired muscle diseases. If we think of, for example, cases where inflammation in the muscle occurs in between muscle fibers, more in the interstitium of the muscle, that disease may not lead to significant elevation of the CK. Dr Albin: That's super helpful. So, I'm hearing you say CK may be helpful, but it's neither completely sensitive nor completely specific when we're thinking about myopathic disorders. Dr Milone: You are correct. Dr Albin: Great. So, coming back to our patients, you know, she says that she has this dysphasia. How do bulbar involvement or extraocular eye movement involvement, how do those help narrow your differential? And what sort of disorders are you thinking of for patients who may have that bulbar or extraocular muscle involvement? Dr Milone: Regarding dysphagia, that can occur in the setting of acquired myopathies relatively frequent; for example, in inclusion body myositis or in other forms of inflammatory myopathy. Your patient, I believe, was in their forties, so it's a little bit too young for inclusion body myositis. Involvement of the extraocular muscles is usually much more common in genetic muscle diseases and much less frequent in hereditary muscle disease. So, if there is involvement of the extraocular muscles, and if there is a dysphagia, and if there is a proximal weakness, you may think about oculopharyngeal muscular dystrophy, for example. But obviously, in a patient who has only six months of history, we have to pay attention of the degree of weakness the patient has developed since the symptom onset. Because if the degree of weakness is mild, yes, it could still be a genetic or could be an acquired disease. But if we have a patient who, in six months, from being normal became unable to climb stairs, then we worry much more about an acquired muscle disease. Dr Albin: That's really helpful. So, the time force of this is really important. And when you're trying to think about, do I put this in sort of a hereditary form of muscle disease, thinking more of an indolent core, something that's going to be slowly progressive versus one of those inflammatory or necrotizing pathologies, that's going to be a much more quick onset, rapidly progressive, Do I have that right? Dr Milone: In general, the statement is correct. They tend, acquired muscle disease, to have a faster course compared to a muscular dystrophy. But there are exceptions. There have been patients with immune mediated necrotizing myopathy who have been misdiagnosed as having limb-girdle muscular dystrophy just because the disease has been very slowly progressive, and vice versa. There may be some genetic muscle diseases that can present in a relatively fast way. And one of these is a lipid storage myopathy, where some patients may develop subacutely weakness, dysphagia, and even respiratory difficulties. Dr Albin: Again, I'm hearing you say that we really have to have an open mind that myopathies can present in a whole bunch of different ways with a bunch of different phenotypes. And so, keeping that in mind, once you suspect someone has a myopathy, looking at the testing from the EMG perspective and then maybe laboratory testing, how do you use that information to guide your work up? Dr Milone: The EMG has a crucial role in the diagnosis of muscle diseases. Because, as we said earlier, weakness could be the result of muscle disease or other form of neuromuscular disease. If the EMG study will show evidence of muscle disease supporting your diagnostic hypothesis, now you have to decide, is this an acquired muscle disease or is this a genetic muscle disease? If you think that, based on clinical history of, perhaps, subacute pores, it is more likely that the patient has an acquired muscle disease, then I would request a muscle biopsy. The muscle biopsy will look for structural abnormalities that could help in narrowing down the type of muscle disease that the patient has. Dr Albin: That's really helpful. When we're sending people to get muscle biopsies, are there any tips that you would give the listeners in terms of what site to biopsy or what site, maybe, not to biopsy? Dr Milone: This is a very important point. A muscle biopsy has the highest diagnostic yield if it's done in a muscle that is weak. And because muscle diseases can result in proximal or distal weakness, if your patient has distal weakness, you should really biopsy a distal muscle. However, we do not wish to biopsy a muscle that is too weak, because otherwise the biopsy sample will result just in fibrous and fatty connected tissue. So, we want to biopsy a muscle that has mild to moderate weakness. Dr Albin: Great. So, a little Goldilocks phenomenon: has to be some weak, but not too weak. You got to get just the right feature there. I love that. That's a really good pearl for our listeners to take. What about on the flip side? Let's say you don't think it's an acquired a muscular disease. How are you handling testing in that situation? Dr Milone: If you think the patient has a genetic muscle disease, you pay a lot of attention to the distribution of the weakness. Ask yourself, what is the best pattern that represent the patient's weakness? So, if I have a patient who has facial weakness, dysphagia, muscle cramping, and then on examination represent myotonia, then at that point we can go straight to a genetic test for myotonic dystrophy type one. Dr Albin: That's super helpful. Dr Milone: So, you request directly that generic test and wait for the result. If positive, you will have proof that your diagnostic hypothesis was correct. Dr Albin: You're using the genetic testing to confirm your hypothesis, not just sending a whole panel of them. You're really informing that testing based on the patient's pattern of weakness and the exam findings, and sometimes even the EMG findings as well. Is that correct? Dr Milone: You are correct, and ideally, yes. And this is true for certain muscle diseases. In addition to myotonic dystrophy type one, for example, if you have a patient who has fascial scapulohumeral muscular weakness, you can directly request a test for FSHD. So, the characterization of the clinical phenotype is crucial before selecting the genetic test for diagnosis. Dr Albin: Wonderful. Dr Milone: However, this is not always possible, because you may have a patient who has just a limb-girdle weakness, and the limb-girdle weakness can be limb-girdle muscular dystrophy. But we know that there are many, many types of limb-girdle muscular dystrophies. Therefore, the phenotype is not sufficient to request specific genetic tests for one specific form of a limb-girdle muscular dystrophy. And in those cases, more complex next-generation sequencing panels have a higher chance of providing the answer. Dr Albin: Got it, that makes sense. So, sometimes we're using a specific genetic test; sometimes, it is unfortunate that we just cannot narrow down to one disease that we might be looking for, and we may need a panel in that situation. Dr Milone: You are correct. Dr Albin: Fantastic. Well, as we wrap up, is there anything on the horizon for muscular disorders that you're really excited about? Dr Milone: Yes, there are a lot of exciting studies ongoing for gene therapy, gene editing. So, these studies are very promising for the treatment of genetic muscle disease, and I'm sure there will be therapists that will improve the patient's quality of life and the disease outcome. Dr Albin: It's really exciting. Well, thank you again. Today I've been interviewing Dr Margarita Malone on her article on a pattern recognition approach to myopathy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining us today. And thank you, Dr Milone. Dr Milone: Thank you, Casey. Very nice chatting with you about this. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Statin Myopathy   Guest: Stephen Kopecky, M.D. Host: Sharonne Hayes, M.D.   Statins are very helpful to lower LDL cholesterol and subsequently lower cardiovascular risk.  Studies of statins have excluded subjects that are statin intolerant which is usually due to muscle symptoms such as aches, called myalgias, muscle cramps, or weakness.  One of the most significant predictors of statin intolerance is the dose -the higher the dose, the more likely to develop intolerance.  Accepted in recommended ways to minimize intolerance is to use generic combination therapy with a lower dose statin and a cholesterol absorption inhibiting agent such as ezetimibe.  Newer agents such as PCS K 9 inhibitors and inclisiran, both given subQ, and bempedoic acid may reduce statin muscle symptoms.   Topics Discussed: Is any statin more or less likely to cause statin associated muscle symptoms? Are there any protective medications that can minimize statin myalgias? What newer non-statin agents have been shown to reduce risk of myalgias? How is treating high cholesterol levels becoming more like treating blood pressure?     Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode.   Podcast episode transcript found here.

This AANEM podcast features Dr. Joome Suh, a neurologist and neuromuscular specialist at Brigham and Women's Hospital, interviewed by neuromuscular fellow Dr. Nadia Khalil. They discuss HMG-CoA reductase immune-mediated necrotizing myopathy (HMGCR IMNM), a rare autoimmune muscle disease often associated with statin use. The discussion covers clinical presentation, epidemiologic considerations, histopathologic findings, and treatment approaches, with special focus on Dr. Suh's recent research published in Muscle and Nerve with co-author Dr. Anthony Amato. Their study found that patients receiving maintenance IVIG as part of their regimen were more likely to have a normal CK at 6 months and the daily prednisone-equivalent was lower. A sub-group analysis suggested IVIG as monotherapy is effective.

Commentary by Dr. Jafar Al-Mondhiry.

Hey everyone, it's Erica. A few months ago, I was scrolling through reels on Instagram, when I came across Louann's page, which is called @themarionnettepianist. Louann is diagnosed with mitochondrial myopathy, a disease that can cause severe muscle weakness. She is also diagnosed with epilepsy. However, she is more importantly a board-certified neurologist and a talented classical pianist. On Louann's feed, what instantly caught my eye were the two intricate harnesses supporting her forearms to play piano. As someone who grew up classically trained in piano and also majored in music, I was really intrigued by her setup, and wanted to chat with her more about it. In this episode, we talk a lot about our favorite composers, the accommodations Louann has had to make for her work and her music, and her incredible sense of resilience through it all. I really enjoyed listening to Louann's story, and hope you will too. Follow Louann and her music here: Youtube: https://www.youtube.com/@UCvxsVb5YnMuBoF1-BobVXgA Instagram: https://www.instagram.com/themarionettepianistFollow the Just Say Maybe Podcast IG here: www.instagram.com/justsaymaybepodcastDisclaimer: This podcast is not a replacement for therapy. Please seek professional help from a licensed clinician or therapist.

In this episode, Prof. Murrell, Head of the Dermatology Department at the St George Hospital, with an academic appointment at the NSW (Sydney, Australia) and several academic appointments in Europe, UK, USA, delves into the fascinating world of autoimmune blistering diseases, joined by her guest, Ailin He, a medical student who recently published ground-breaking research in the Journal of Dermatology and Venereology (JEADV). In their article, Autoimmune blistering diseases treated with glucocorticoids: An international study of steroid-induced myopathy, they present a multi-country study involving 139 patients, revealing the prevalence, risk factors, and recovery patterns of this condition. Together, the two speakers explore steroid-induced myopathy, a complication of prolonged glucocorticoid use often overlooked in dermatology. Tune in to learn about the innovative Glucocorticoid Toxicity Index (GTI), the impact of cumulative steroid doses, and strategies to improve patient outcomes and offering a hopeful outlook for managing complex autoimmune conditions. Find the link to the article here: https://onlinelibrary.wiley.com/doi/10.1111/jdv.20149 Don't miss out!   Link to video version: https://www.youtube.com/playlist?list=PL2DbuyADMP5mFx4sZqS_vQtdTGOGIbwb1   You are invited to participate in our survey to improve the show. Your feedback is valued and appreciated to allow us to better serve our audience: https://eadv.org/eadv-podcast-survey/  

This week I am joined by special guest, Dr. Katie Young, an equine nutritionist who consults for Kentucky Equine Research and who councils clients independently. Dr. Young has spend her career in the equine feed industry and is a wealth of experience an knowledge! This week, Dr. Young talks about Myofibrillar Myopathy (MFM) in horses. We'll discuss how it differs from polysaccharide storage myopathy (PSSM) (types 1 and 2), what to look for and how to support MFM from a dietary standpoint. Horses with MFM may present with decreased performance or unwillingness to go forward. Dietary management is quite different from PSSM. Listen in to learn more!*Cover Art Graphic from: Koutakis, et al., 2015. Abnormal Accumulation of Desmin in Gastrocnemius Myofibers of Patients with Peripheral Artery Disease: Association with Altered Myofiber Morphology and Density, Mitochondrial Dysfunction and Impaired Limb Function. Journal of Histochemistry and Cytochemistry. DOI:10.1369/0022155415569348 Additional reading on MFM can be found at these links:https://ker.com/nmdl/resources/mfm/Valberg, et al., 2017. Clinical and histopathological features of myofibrillar myopathy in Warmblood horses. Equine Vet J.;49(6):739-745. Online at: https://pubmed.ncbi.nlm.nih.gov/28543538/ Dr. Stephanie Valberg herself explains the diagnostics of MFM: https://www.youtube.com/watch?v=HdkNMUMhQvY

In this episode of ListenABLE, host Angus O'Loughlin sits down with Amy Evans—a dynamic 26-year-old and owner of 'Little Black Digital' marketing agency, living with a rare genetic condition called Nemaline Rod Muscular Myopathy. Amy opens up about her journey growing up as a twin who has the same disability and the power of support systems. As well as the inclusive world of fashion, horse racing and what it's like to live in a day with Nemaline Myopathy. Amy also shares a confronting behind the curtain look of the critical impacts of COVID-19 when it came to healthcare access for those with disabilities.  "We are contributing members of our society that pay our taxes... why should someone like us not be prioritised..." Want to support Amy and her business/content? Instagram: https://www.instagram.com/amy_c_evans/ Little Black Dress Digital: https://lbddigital.com.au/ Watch the Full Episode with Captions Here: https://youtu.be/Fi4WhhHVDVM Grab our first merch release at our website Session in Progress.Recorded, edited and produced by Angus' Podcast Company: www.sessioninprogress.com.auSee omnystudio.com/listener for privacy information.

Drs. Gordon Smith, Shahar Shelly, and Teerin Liewluck discuss the correlation between CMAP duration and myosin loss and their effect on mortality by comparing between patients with CIM with and without myosin loss.  Show references: https://www.neurology.org/doi/10.1212/WNL.0000000000209496 

Dr. Gordon Smith talks with Drs. Shahar Shelly and Teerin Liewluck about the correlation between CMAP duration and myosin loss and their effect on mortality by comparing between patients with CIM with and without myosin loss. Read the related article in Neurology.  Disclosures can be found at Neurology.org.

In this episode of My Thyroid Health, we discover the connection between hypothyroidism and the muscle weakness known as myopathy. What you will learn: What is hypothyroid myopathy? What are the causes and symptoms of hypothyroid myopathy? What are the four subtypes of hypothyroid myopathy How is hypothyroid myopathy diagnosed and treated? A note from Paloma ⁠Check out our blog and read the full article here.⁠ About Paloma Health: ⁠⁠⁠Paloma Health⁠⁠⁠ is an online medical practice focused exclusively on treating hypothyroidism. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you.  ⁠⁠⁠Become a member⁠⁠⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout. Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Our Carrier Connections program features a different X-linked condition each month with the goal to increase awareness of X-linked conditions and how they impact the lives of women and girls. This month, we are featuring myotubular myopathy (MTM). MTM is an X-linked genetic disorder characterized by moderate to severe muscle weakness and decreased muscle tone. Manifesting female carriers of an MTM1 mutation express a range of symptoms that vary in severity, but the following describe the general pattern seen across studies: Muscle weakness in upper and lower limbs  Muscle atrophy  Dyspnea  Muscle fatigue Cramping Calf enlargement  Wheelchair dependence Intolerance to physical activity  Contractures  Choking while eating  Vocal changes Today we are bring on Meghan Mustane to discuss her experience of being diagnosed a carrier with MTM. Meghan is an experienced communications professional working in Pharma and is currently on the board for Remember The Girls. She is a carrier of Myotubular Myopathy and always knew there was a chance she was a carrier from her mothers own journey in family planning and child loss. Meghan is a mother of two girls, age 14 and 9 and knows one day they will require testing to find out their own carrier status with the condition. The ethics of when to talk to your daughter and when to find out your children's own carrier journey is always a debated topic in our community and one that is very personal and also very grey. Meghan is passionate about raising awareness for rare diseases and we appreciate her continued efforts and support inside Remember The Girls. Carrier Connections is sponsored by Kyowa Kirin and Amgen. For more information about our organization, check out rememberthegirls.org.

Our Carrier Connections program features a different X-linked condition each month with the goal to increase awareness of X-linked conditions and how they impact the lives of women and girls. This month, we are featuring myotubular myopathy (MTM). MTM is an X-linked genetic disorder characterized by moderate to severe muscle weakness and decreased muscle tone. Manifesting female carriers of an MTM1 mutation express a range of symptoms that vary in severity, but the following describe the general pattern seen across studies: Muscle weakness in upper and lower limbs Muscle atrophy Dyspnea Muscle fatigue Cramping Calf enlargement Wheelchair dependence Intolerance to physical activity Contractures Choking while eating Vocal changes Today we are bring on Kim Engst to discuss her experience being diagnosed with MTM. Kim is a manifesting carrier of MTM. She has a daughter and a son who passed away from MTM. She is a retired Veterinary Technician of 40 years, a career she loved! She is a lizard mom, I have 3 crested geckos: Emilio, Flora and Fauna. She is a voracious reader and enjoy doing paint by numbers kits (great for mental health and keeping her hands moving!) Carrier Connections is sponsored by Kyowa Kirin and Amgen. For more information about our organization, check out ⁠⁠⁠⁠⁠⁠rememberthegirls.org⁠⁠⁠⁠⁠⁠.

Our Carrier Connections program features a different X-linked condition each month with the goal to increase awareness of X-linked conditions and how they impact the lives of women and girls. This month, we are featuring myotubular myopathy (MTM). MTM is an X-linked genetic disorder characterized by moderate to severe muscle weakness and decreased muscle tone. Manifesting female carriers of an MTM1 mutation express a range of symptoms that vary in severity, but the following describe the general pattern seen across studies: Muscle weakness in upper and lower limbs Muscle atrophy Dyspnea Muscle fatigue Cramping Calf enlargement Wheelchair dependence Intolerance to physical activity Contractures Choking while eating Vocal changes Today, we are interviewing Jessica Stanley, a female patient with myotubular myopathy. Jessica was mis-diagnosed multiple times and ultimately found out her MTM diagnosis through genetic testing. She is currently pregnant with twin baby girls and has been contemplating testing for their carrier status in utero. Women patients and carriers of x-linked conditions not only find themselves with physical symptoms of their condition but also the mental load of making these tough decisions can be daunting. Jessica is a beautiful example of how community and staying positive can ultimately help bring women together, sharing their journey with each other. Carrier Connections is sponsored by Kyowa Kirin and Amgen. For more information about our organization, check out ⁠⁠⁠⁠⁠rememberthegirls.org⁠⁠⁠⁠⁠.

This week, we talked more specifically about statin- and cholesterol-lowering medication induced myopathy. Ron is only a tiny bit better but still can’t ride his bike outdoors. We talked about studies showing that athletes and people of lower body habitus tend to have more bad reactions to cholesterol lowering medications. My hypothesis is that doctors […]

This week, we unfortunately found out that Ron had to get off his bike to help his legs heal further. The PCSK-9 inhibitor may still be in his body, and when he exerts himself his muscles hurt. We are doing everything we can to speed the process of healing, including proteolytic enzymes to break down […]

THE PICKLE JARADRENAL INSUFFICIENCY PODCASTFor over 2 years Jill has been trying to FIGURE out what is happening to her hands. Her first symptom was having a hard time opening packages followed by her fingers 'falling' away from the joints. Initial tests show no arthritis, and no carpal tunnel...all the 'usual' causes were eliminated.Living with a RARE chronic illness you are 'warned' these illnesses travel in 'packs'. Instant fear and anxiety...which illness is this now?EMGs, PLASTIC SURGEON, MUSCLE TESTING and more all lead to the conclusion this is a steroid side effect.Today Jill had an appointment with a rheumatologist who agreed. Her tiny hands are losing muscle from over 13 years of steroid use. Watch on YouTube "CHRONICALLY FIT CANADA" and find out what Jill needs to do to BATTLE back against STEROID MYOPATHY. Watch on YOUTUBE "CHRONICALLY FIT CANADA" and if you have experienced this as well Jill would love for you to leave a comment. And if you find value in these episodes make sure you subscribe so you do not miss when one is posted. More details go to:www.chronicallyfitcanada.com

About this interview: I've let Adam introduce himself - "I was a high profile, Senior Sports Physiotherapist and Head of Medical for professional sports clubs including regional and national Rugby League and at the PGA Golf Tour, Professional Ballet and MOD. I was extremely physically fit and in very good health. Unfortunately, after having the AstraZeneca, Covid vaccine, I became severely unwell and have experienced Pulmonary Embolisms, Ventricular Tachycardia, Severe demyelination of nerves, Myopathy, Dysautonomia, Chronic chest pain to name only a few of my main health problems sustained. My life has been completely destroyed. I can no longer work and have had to move in with my mum. I'm housebound without help and find it extremely difficult to manage on a day to day basis both physically and mentally and have needed a carer. I am speaking out about my experience to raise awareness and hopefully stop this happening to anybody else. I hope people can learn from my experience. I hope one day all the vaccine injured get justice for themselves and their families." Links - Twitter Adam Rowland Twitter GoFundMe Adam Rowland GoFundMe If you value my podcasts, please support the show so that I can continue to speak up by choosing one or both of the following options - ⁠Buy me a coffee⁠ If you want to make a one off donation. Join my Substack To access additional content, you can upgrade to paid from just £3.50 a month To sponsor the Doc Malik Podcast contact us at ⁠hello@docmalik.com⁠  About Doc Malik: Orthopaedic surgeon Ahmad Malik is on a journey of discovery when it comes to health and wellness. Through honest conversations with captivating individuals, Ahmad explores an array of topics that profoundly impact our well-being and health. You can follow us on social media, we are on the following platforms: ⁠Twitter Ahmad⁠ | ⁠Twitter Podcast⁠ | ⁠Instagram Ahmad⁠ | ⁠Instagram Podcast

Dr. Amel Karaa discusses the use of elamipretide in participants with genetically confirmed primary mitochondrial myopathies. Show references: https://n.neurology.org/content/101/3/e238  

Dr. Justin Abbatemarco talks with Dr. Amel Karaa about the use of elamipretide in participants with genetically confirmed primary mitochondrial myopathies. Read the related article in Neurology.  Visit NPUb.org/Podcast for associated article links.

In episode 57 of the Summits Podcast, co-hosts Vince Todd, Jr. and Daniel Abdallah are joined by Dr. Bill Tierney of the Fairbanks School of Public Health in its Department of Global Health. Tune in as Dr. Tierney shares his long-standing career in medical research and how surviving cancer made him a more empathetic doctor. Subscribe to the audio version of the Summits Podcast https://summitspodcast.fireside.fm Find out more about the Heroes Foundation https://www.heroesfoundation.org Find out more about The Brookfield Group https://thebrookfieldgroup.com Discover Platform 24 co-working https://www.platform24.co What's your cancer story? Hosted by cancer survivor and philanthropist Vince Todd, Jr., Chairman and Co-Founder of the Heroes Foundation, and Heroes Foundation Board Member Daniel Abdallah, the Summits Podcast is a place for people to share their stories. Everyone has a cancer story. From battling a deadly disease to caring for a loved one, when we rise up and face life's greatest challenges, we see with a new vision, feel with a greater passion, and think with a deeper perspective. Along the way, paths cross, journeys intersect, and missions converge. For Vince Todd, it was his own cancer diagnosis that led him and his wife, Cindy, to launch the Heroes Foundation to provide meaningful support to cancer patients, education to promote cancer prevention, and resources to advance research for a cure. What started with friends and family grew into a community. The Summits Podcast is an extension of that community. Our stories are what bring us together. Artists, athletes, doctors, business people - we're all family members, community leaders, and activists. Everyone has a story. Anyone can inspire. No one battles alone. Join the conversation. Let's climb the summit together.

Dr Glenn McConell chats with Professor Mark Tarnopolsky from McMaster University in Canada. Mark has done pioneering studies in many areas including sex differences and exercise, HITT training and creatine supplementation. Today we focus on his remarkable work with muscle myopathies. Exercise can be beneficial in all muscle myopathies in regards to function and/or healthspan and/or lifespan. The type of exercise will differ depending on the myopathy: endurance, resistance, or both.0:00. Introduction and overview of Mark's exercise, clinical and research4:45. McMaster University: Stu Phillips, Marty Gibala and Mark6:30. His sex differences and exercise research8:06. Exosomes re drug delivery and exercise15:48. Types of muscle myopathies19:39. Exercise can improve McArdles disease24:29. Weight training, creatine and McArdles disease28:20. Exercise and glycoytic defects, glucose ingestion/fasting30:53. Creatine phosphate34:50. Rhabdomyolysis39:53. Mark's very impressive sporting background and lab numbers41:45. Mark's cardiac ablations42:48. The heart and VO2 max etc43:49. Mitochondrial disease and exercise/RER48:30. Ex training increases VO2 max in mitochondrial disease51:00. Most common mitochondrial diseases53:20. How does exercise improve exercise in mitochondrial diseases55:00. Muscle affected in different genetic deficits57:26. Neuromuscular junction with Dr Tarnopolsky on YouTube58:17. Exercise beneficial with pretty much every muscle disease58:40. Exercise improves strength in Inclusion body myopathy58:50. Exercise improves function etc in muscular dystrophy59:5 Pompe disease. Exercise better than $1million/yr treatment1:01:18. Tends to be focus on pharma despite exercise being better1:03:35. Duchenne muscular dystrophy, exercise and life expectancy1:09.02. Resistance vs strength vs both in muscle defects1:11:38. Different resistance training tactics in mitochondrial patients1:13:02. Creatine and other supplements in muscle defects1:16:29. Study designs, funding,patents etc1:18:07. Do people who don't have muscle myopathies need supplements?1:19:11. Disclosure: Founder and CEO of the Exerkine Company1:21:40. “Exercise the best supplement”1:23:59. Exokines within exosomes not that useful so far1:28:24. Take away messages1:31:42. Mark's running ability/injuries as age etc.1:33:57. Mark's injuries/diet/supplements1:36:54. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: glenn.mcconell@gmail.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice.Disclosure: Prof Tarnopolsky is the Founder and CEO of the Exerkine Company.

It's another COVID-19 special on this month's JHLT: The Podcast, which features two articles on COVID-19 and thoracic organ transplantation from the April issue of The Journal of Heart and Lung Transplantation.   First, the editors explore a study entitled “Heart transplantation for COVID-19 myopathy in the United States,” which comes from Gill and colleagues at Cedars Sinai Medical Center in Los Angeles.   The editors welcome first author George Gill, MD, to share what brought him from the United Kingdom to the States, and to talk about the findings of the study. The Digital Media Editors want to know how COVID-19 myocarditis impacts immune response in transplantation, how Dr. Gill manages different etiologies of cardiomyopathy, and some of the limitations of the study.   Next, the editors welcome senior author Nicolaus Schwerk, MD, from Hannover Medical School in Germany to discuss the paper, “COVID-19 in pediatric lung transplant recipients: Clinical Course and outcome.”   Dr. Schwerk is an expert in rare diffuse parenchymal lung diseases and end stage lung diseases, as well as congenital thoracic malformations in children, and performs lung transplantation. This single-center study investigated the impact of SARS-COV-2 infection on pediatric lung transplant recipients between March 2020 and June 2022 at Hannover Medical Center. The key finding of the study was that the COVID-19-positive pediatric lung transplant recipients did remarkably well.   The digital media editors dig in with Dr. Schwerk on the pace of COVID-19 infections in Europe, why antivirals are used differently in pediatric patients, and why pediatric patients typically experience a more mild course of disease.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

 On this episode, Karen speaks with Paul Frase, 11-year NFL Super Bowl veteran, and Alison Rockett, CEO and President and Co-Founder of The Joshua Frase Foundation, the parents of Isabella and Joshua. Joshua was born on February 2, 1995, with an ultra-rare and fatal neuromuscular disorder called myotubular myopathy and passed away on December 24, 2010, at the age of 15. Myotubular myopathy claims the lives of 50 percent of its victims before the age of 2. During Joshua's life, Paul and Alison created Joshua's legacy, The Joshua Frase Foundation, a non-profit that raises funds for cutting-edge research in regenerative medicine, gene therapy and genetics. Paul and Alison are here to share the story of their son's life and the impact that The Joshua Frase Foundation has had on finding a cure for myotubular myopathy.

GUEST 1 OVERVIEW: Pauline Hanson is the Senator for Queensland and Leader of One Nation Party. GUEST 2 OVERVIEW: Adam is a 48 year old father of 4. He was super fit and spent the last 17 years working in professional sport as 'Head of Medical Physiotherapist' and 'Trainer and Strength Conditioner'. Adam also worked in senior roles for 'Northern Ballet', ' England Knights Rugby League', 'Castleford Tigers Rugby League', 'St Helens Rugby League', 'Warrington Rugby League', 'Leigh Rugby League' and 'Widness Rugby League'. ' Also was part of UK Tri Forces Military both in the UK and on an operational overseas basis. Adam was part of the PGA golf tour with Patrick Cantley and Jason Day. Adam had Asrazenaka shot Feb and then May 2021. Since Adam has been vaccinated he has been diagnosed with ..... Heart RVOT VT arthymia, Heart Peri/Myocarditis, a blood clotting disease (still trying to work out what exactly it is), suspected Thrombotic Thrombocytopenia, Severe Vaccine Mediated Thrombotic Vasculitus, Widespread Vascular Neuropathy. Adam is also under investigation for Myopathy. Also has long list of symptoms including non-epileptic fits, tinnitus, blurred vision, dysautonimia. Adam approached approximately 50 mainstream media outlets and was turned away, this did not deter Adam who wants to get his information out there to help prevent people taking the COVID jab and save them from going through similar adverse reactions and/or death which is also classed as a side effect from the COVID19 vaccines. 

A client has pain, tension, and a specific referral pattern between her right shoulder and left leg. She was also born with a rare disease that affects her mitochondria, and that carries a host of complications, like high blood pressure, headaches, and diabetes. Can massage therapy help reduce her tension, even if it is led by mitochondrial dysfunction? We ask that question and discuss on this episode of “I Have a Client Who . . .”   Sponsors:     Books of Discovery: www.booksofdiscovery.com     Host Bio:                    Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com.                     Recent Articles by Ruth:          “Working with Invisible Pain,” Massage & Bodywork magazine, November/December 2022, page 36, http://www.massageandbodyworkdigital.com/i/1481961-november-december-2022/38   “Unpacking the Long Haul,” Massage & Bodywork magazine, January/February 2022, page 35, www.massageandbodyworkdigital.com/i/1439667-january-february-2022/36.   “Chemotherapy-Induced Peripheral Neuropathy and Massage Therapy,” Massage & Bodywork magazine, September/October 2021, page 33, http://www.massageandbodyworkdigital.com/i/1402696-september-october-2021/34.           “Pharmacology Basics for Massage Therapists,” Massage & Bodywork magazine, July/August 2021, page 32, www.massageandbodyworkdigital.com/i/1384577-july-august-2021/34.       Resources:    Pocket Pathology: https://www.abmp.com/abmp-pocket-pathology-app   Mitochondria (no date) Genome.gov. Available at: https://www.genome.gov/genetics-glossary/Mitochondria (Accessed: 2 December 2022).   Mitochondrial Myopathies | National Institute of Neurological Disorders and Stroke (no date). Available at: https://www.ninds.nih.gov/health-information/disorders/mitochondrial-myopathies (Accessed: 1 December 2022).   Mitochondrial Myopathy Fact Sheet | National Institute of Neurological Disorders and Stroke (no date). Available at: https://www.ninds.nih.gov/mitochondrial-myopathy-fact-sheet (Accessed: 1 December 2022).   Philadelphia, T.C.H. of (2019) Mitochondrial Myopathy. The Children's Hospital of Philadelphia. Available at: https://www.chop.edu/conditions-diseases/mitochondrial-myopathy (Accessed: 6 December 2022).   ‘Primary Mitochondrial Myopathies' (no date) NORD (National Organization for Rare Disorders). Available at: https://rarediseases.org/rare-diseases/primary-mitochondrial-myopathies/ (Accessed: 1 December 2022).  

Recap and review the top pearls from recent episodes #339 Hand and Wrist Pain, #348 Foot and Ankle Pain,  and #351 Myopathy and Myositis with Watto and Paul. It's Tales from the Curbside! (TFTC), our monthly series providing a rapid review of recent Curbsiders episodes for your spaced learning. Note No CME for this mini-episode but visit curbsiders.vcuhealth.org to claim credit for shows #339, #348 and #351! Episodes | Subscribe | Spotify | Swag! | Mailing List | askcurbsiders@gmail.com | Free CME! Show Segments Intro, disclaimer, guest bio Hand and Wrist pain: CMC joint arthritis, tenosynovitis, carpal tunnel syndrome, trigger finger Foot and Ankle pain: Ankle sprains, Achilles tendon injuries, Posterior tibial tendon dysfunction Myopathy and Myositis pearls Outro Credits Written, Produced, and Hosted by: Matthew Watto MD, FACP; Paul Williams MD, FACP   Show Notes: Matthew Watto MD, FACP TFTC Cover Art design: Edison Jyang Technical Production: Pod Paste Full transcript HERE

On this episode, Dr. Axtmayer and Dr. Parker talked about sciatica, what causes it, what can people do to rehab it, and more. They also talked about arthritis, statin induced myopathy, and about the importance of knowing some pharmacology if you work in the rehab setting. Enjoy!

TRC Editor, Dr. Lori Dickerson, PharmD, FCCP talks with Joseph Saseen, PharmD, FCCP, FNLA, Associate Dean for Clinical Affairs, Professor, Department of Clinical Pharmacy and Professor, Department of Family Medicine from the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado Anschutz Medical Campus about managing statin intolerance. Listen in as they discuss how to evaluate statin-associated muscle pain...and review strategies to help patients take a statin successfully. You'll also hear practical advice from panelists on TRC's Editorial Advisory Board:Andrea Darby Stewart, MD, Associate Director, Family Medicine Residency at Honor HealthAnthony A. Donato, Jr., MD, MHPE, Associate Program Director, Internal Medicine from the Reading Health System, and Professor of Medicine at the Sidney Kimmel Medical College at Thomas Jefferson UniversitySteven E. Nissen, MD, MACC, the Chief Academic Officer at the Heart and Vascular Institute and the Lewis and Patricia Dickey Chair in Cardiovascular Medicine Professor of Medicine at the Cleveland Clinic Lerner School of Medicine at Case Western Reserve UniversityJoseph Scherger, MD, MPH, Family Physician, Primary Care 365, Eisenhower HealthCraig D. Williams, PharmD, FNLA, BCPS, Clinical Professor, Department of Pharmacy Practice at the Oregon Health and Science UniversityFor the purposes of disclosure, Dr. Steven Nissen reports a relevant financial relationship with AbbVie, Amgen, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Esperion, Medtronic, Novartis, Pfizer, Silence Therapeutics (grants/research support).The other speakers have nothing to disclose. All relevant financial relationships have been mitigated.Pharmacist's Letter offers CE credit for this podcast. Log in to your Pharmacist's Letter account and look for the title of this podcast in the list of available CE courses.If you're not yet a Pharmacist's Letter subscriber, find out more about our product offerings at trchealthcare.com. Follow or subscribe, rate, and review this show in your favorite podcast app. You can also reach out to provide feedback or make suggestions by emailing us at ContactUs@trchealthcare.com. 

Learn to recognize myositis and myopathy (aka the idiopathic inflammatory myopathies), perform the appropriate initial testing, whether or not statins and exercise are safe to continue, and how to partner with our subspecialist colleagues to treat these patients in primary care.  Recorded LIVE at Johns Hopkins, we're joined by Dr. Lisa Christopher-Stine, @DrLisaCS of @HopkinsMedicine, a rheumatologist and leading expert on myositis and myopathy!  Claim free CME for this episode at curbsiders.vcuhealth.org! Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Show Segments Intro, disclaimer, guest bio Guest one-liner, Picks of the Week* Case from Kashlak History and Exam Workup for suspected myositis Cancer screening Safety of statin use and exercise Our role in primary care Audience Questions Outro Credits Written and Produced by: Matthew Watto MD, FACP Show Notes: Matthew Watto MD, FACP Cover Art and Infographic: Andréa Perdigão Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Molly Heublein MD Technical Production: Pod Paste Guest: Lisa Christopher-Stine MD, MPH Sponsor: Grammarly Go to grammarly.com/CURB to sign up for a free account and 20% off when you upgrade to Grammarly Premium. Sponsor: Betterhelp Visit BetterHelp.com/Curb to get 10% off your first month. Sponsor: Wildgrain Sign up at Wildgrain.com/CURB or use CURB at the checkout to get $30 off your first box plus free croissants in every box. Full Transcript HERE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org and search for this episode to claim credit. 

Join us with Stealth BioTherapeutics CEO Travis Wilson and others from the Stealth BT team for a live update from Stealth BT (click here to check out their website), information about Bendavia, and details about StealthBioTherapeutics' 2015 mitochondrial myopathy clinical trial. A Q&A opportunity is included in this important discussion. Parents, patients and families - please join us! This special teleconference/webinar is offered in collaboration by the UMDF and MitoAction. For more information about the Stealth Mitochondrial Myopathy Trial, please call the trial question hotline 1-877-227-5018 Or visit www.clinicaltrials.gov (search Bendavia) Trial Question Hot Line: 1-877-227-5018 https://www.mitoaction.org/resources/stealth-bt-mitochondrial-myopathy-trial/

In this episode we are joined by Senior Clinical Lecturer and Consultant Neurologist Dr James Lilleker to discuss how he approaches the patient presenting with a suspected myopathy

If you are too busy to read the EMEUNET What Is New contributions (https://emeunet.eular.org/what_is_new.cfm), this podcast is exactly for you. Now you can get updated while on the go, with highlights of the most recent publications in the field of Rheumatology, selected for you by EMEUNET members.

Editor's Summary by Kristin Walter, MD, Associate Editor of JAMA, the Journal of the American Medical Association, for the March 22/29, 2022, issue.

AWARENESS IS CRUCIAL FOR LEADERS HOWEVER MYOPATHY AND FOCUS ARE SEPARATED BY A VERY THIN LINE “Leaders must be willing to do the hard work of self leadership, self awareness and personal introspection. Leaders must also understand the line between focus and myopathy. It's entirely too easy to become so wrapped up in personal issues and lose sight of the bigger picture and its global impact. Its great to focus on self improvement and self empowerment just don't lose the perspective of larger reality and the role you play in it.” J Loren Norris WATCH THE VIDEO #leadingleaderspodcast 12-28-21: http://www.jlorennorris.com/podcast/awareness-is-crucial-for-leaders-however-myopathy-and-focus-are-separated-by-a-very-thin-line LOOK FOR LEADING LEADERS ON LIFTABLE.TV ​______________________________ Leading Leaders Podcast is a short but impactful leadership video, blog and podcast distributed 5 days a week by J Loren Norris to promote faith, family and freedom in the face of a global leadership drought. Leadership Training, Interviews and Entertainment #leadingleaderspodcast #storypower #transforminggracetv #jlorennorris jlorennorris.com/podcast Copyright 2021 Tell It Like It Is Inc --- Send in a voice message: https://anchor.fm/j-loren-norris/message

AWARENESS IS CRUCIAL FOR LEADERS HOWEVER MYOPATHY AND FOCUS ARE SEPARATED BY A VERY THIN LINE “Leaders must be willing to do the hard work of self leadership, self awareness and personal introspection. Leaders must also understand the line between focus and myopathy. It's entirely too easy to become so wrapped up in personal issues and lose sight of the bigger picture and its global impact. Its great to focus on self improvement and self empowerment just don't lose the perspective of larger reality and the role you play in it.” J Loren Norris WATCH THE VIDEO #leadingleaderspodcast 12-28-21: http://www.jlorennorris.com/podcast/awareness-is-crucial-for-leaders-however-myopathy-and-focus-are-separated-by-a-very-thin-line LOOK FOR LEADING LEADERS ON LIFTABLE.TV ​______________________________ Leading Leaders Podcast is a short but impactful leadership video, blog and podcast distributed 5 days a week by J Loren Norris to promote faith, family and freedom in the face of a global leadership drought. Leadership Training, Interviews and Entertainment #leadingleaderspodcast #storypower #transforminggracetv #jlorennorris jlorennorris.com/podcast Copyright 2021 Tell It Like It Is Inc --- Send in a voice message: https://anchor.fm/j-loren-norris/message

The guys return again after a false start last year and the mess that was 2020 (and part of 2021.) Will they survive? Will they record again? That's the plan. This week's tangents include: dieting to relieve stress, college radio, the story of why Chad's grandfather believed in UFOS, a strange magazine synchronicity, Dune vs The Foundation, the question of what is Dune really about, mall culture, dealing with PTSD, Cognitive Behavioral Therapy, and why the transporters on Star Trek are murder machines.Mentioned MediaPatreon link: College Dropout Radio #1TV: Star Trek: VoyagerPodcast: Ep 35 - Chaotic Neutral with LamMagazine: FateMovie: DuneTV: FoundationBook: DuneBook: FoundationThe Robot SeriesJasper MallToto- Africa (playing in an empty shopping centre)Book: Born on the Fourth of JulyMovie: Born on the Fourth of JulyBook: Dawn of the New EverythingBook: Get Out of Your Mind and Into Your LifePodcast: Ep 42 - Missing Logic in Missing 411Follow Lam on InstagramSubscribe to C.A.’s Substack Get full access to Graphorrhea at cahall.substack.com/subscribe

The guys return again after a false start last year and the mess that was 2020 (and part of 2021.) Will they survive? Will they record again? That's the plan. This week's tangents include: dieting to relieve stress, college radio, the story of why Chad's grandfather believed in UFOS, a strange magazine synchronicity, Dune vs The Foundation, the question of what is Dune really about, mall culture, dealing with PTSD, Cognitive Behavioral Therapy, and why the transporters on Star Trek are murder machines.Mentioned MediaPatreon link: College Dropout Radio #1TV: Star Trek: VoyagerPodcast: Ep 35 - Chaotic Neutral with LamMagazine: FateMovie: DuneTV: FoundationBook: DuneBook: FoundationThe Robot SeriesJasper MallToto- Africa (playing in an empty shopping centre)Book: Born on the Fourth of JulyMovie: Born on the Fourth of JulyBook: Dawn of the New EverythingBook: Get Out of Your Mind and Into Your LifePodcast: Ep 42 - Missing Logic in Missing 411Follow Lam on InstagramSubscribe to C.A.’s Substack Get full access to It Matters But It Doesn't at itmattersbut.substack.com/subscribe

The guys return again after a false start last year and the mess that was 2020 (and part of 2021.) Will they survive? Will they record again? That's the plan. This week's tangents include: dieting to relieve stress, college radio, the story of why Chad's grandfather believed in UFOS, a strange magazine synchronicity, Dune vs The Foundation, the question of what is Dune really about, mall culture, dealing with PTSD, Cognitive Behavioral Therapy, and why the transporters on Star Trek are murder machines. Mentioned MediaPatreon link: https://www.patreon.com/posts/college-dropout-55510719?utm_medium=clipboard_copy&utm_source=copy_to_clipboard&utm_campaign=postshare (College Dropout Radio #1) TV: https://reelgood.com/show/star-trek-voyager-1995 (Star Trek: Voyager) Podcast: https://www.itmattersbutitdoesnt.com/35-call-chaotic-neutral-with-lam-nguyen/ (Ep 35 - Chaotic Neutral with Lam) Magazine: https://www.fatemag.com/ (Fate) Movie: https://reelgood.com/movie/dune-2020 (Dune) TV: https://reelgood.com/show/foundation-2020 (Foundation) Book: https://www.amazon.com/gp/product/B00B7NPRY8/ref=as_li_qf_asin_il_tl?ie=UTF8&tag=reawitrazbla-20&creative=9325&linkCode=as2&creativeASIN=B00B7NPRY8&linkId=c73683c1d34d5b2aad88a8f34dad54cc (Dune) Book: https://www.amazon.com/gp/product/B000FC1PWA/ref=as_li_qf_asin_il_tl?ie=UTF8&tag=reawitrazbla-20&creative=9325&linkCode=as2&creativeASIN=B000FC1PWA&linkId=93e25d6944a6030f28b6b4803458843b (Foundation) https://www.goodreads.com/book/show/138551.The_Robot_Novels?from_search=true&from_srp=true&qid=aHBw5yln1l&rank=2 (The Robot Series) https://reelgood.com/movie/jasper-mall-2020 (Jasper Mall) https://youtu.be/D__6hwqjZAs (Toto- Africa (playing in an empty shopping centre)) Book: https://www.amazon.com/gp/product/1617754692/ref=as_li_qf_asin_il_tl?ie=UTF8&tag=reawitrazbla-20&creative=9325&linkCode=as2&creativeASIN=1617754692&linkId=c4fd69ea0988329a73bba64ff657f016 (Born on the Fourth of July) Movie: https://reelgood.com/movie/born-on-the-fourth-of-july-1989 (Born on the Fourth of July) Book: https://www.amazon.com/gp/product/B071RBPV1V/ref=as_li_qf_asin_il_tl?ie=UTF8&tag=reawitrazbla-20&creative=9325&linkCode=as2&creativeASIN=B071RBPV1V&linkId=d491d79dda2696c40ef7adba819f44dc (Dawn of the New Everything) Book: https://www.amazon.com/gp/product/1572244259/ref=as_li_qf_asin_il_tl?ie=UTF8&tag=reawitrazbla-20&creative=9325&linkCode=as2&creativeASIN=1572244259&linkId=43e714fe7e302d2e7e15abebf8aede17 (Get Out of Your Mind and Into Your Life) Podcast: https://www.itmattersbutitdoesnt.com/42-missing-logic-in-missing-411/ (Ep 42 - Missing Logic in Missing 411) https://www.itmattersbutitdoesnt.com/tag/it-podcast/ (C's Solo Podcast: It Matters But It Doesn't) https://patreon.com/chadhall (C's Patreon) https://www.instagram.com/thevacantroom/ (Lam's Instagram) https://twitter.com/lamnguyencomms (Lam's Twitter)

We are joined by our absolute favourite person, Angela Jones, our very own resident Podcast Pet Vet, to talk all about Atypical Myopathy, what's a myopathy? Why is it not typical? Guess you'll have to listen won't you

This week we delve into the world of myocarditis and cardiogenetics when we review a recent work on deleterious cardiomyopathic genes and a possible role for these in patients who have unfavorable myocarditis outcomes. Are cardiomyopathy genes seen more commonly in pediatric patients with myocarditis who die? Is there a role for genetic testing in the myocarditis patient? How might deleterious genetic defects influence outcomes in myocarditis? We speak with Assistant Professor of Medicine at The Icahn School of Medicine at Mount Sinai, Amy Kontorovich who is the first author of this week's work. DOI: 10.1161/CIRCGEN.121.003426

Myopathy is a common reason for discontinuation of statin medications. The recent SAMSON study examined the nocebo effect and how this may bias patients towards treatment failure. How can clinicians overcome the nocebo effect? This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today! Reference: Wood F, Howard J, Finegold J, et al. N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects. N Engl J Med 2020; 383:2182-2184. DOI: 10.1056/NEJMc2031173 See omnystudio.com/listener for privacy information. Learn more about your ad choices. Visit megaphone.fm/adchoices

What is Mitochondrial Myopathy? my·op·a·thy mīˈäpəTHē/ The word “myopathy” means disease of the muscle tissue. As the term implies, mitochondrial myopathy (MM) is a neuromuscular disease caused by damage to the mitochondria. Many patients with mitochondrial disease have a mitochondrial myopathy, either as their sole diagnosis or as an additional, descriptive co-diagnosis as part of their mitochondrial disorder. Mitochondrial myopathy may be present in adults and children, and may occur with or without a genetic mitochondrial disease diagnosis. Further, several clinical trials are currently examining the impact of various therapies or potential treatments for people with mitochondrial myopathy. Join us this month on Friday, November 20th at 12 pm EST with Dr. Bruce Cohen, Director of Pediatric Neurology and then the Director of the NeuroDevelopmental Science Center at Akron Children’s Hospital. Dr. Cohen is well-known and highly respected as an expert author, speaker, clinician and research investigator in mitochondrial disorders. Topics for this important discussion include: What is mitochondrial myopathy? How is it diagnosed? Are there treatments for mitochondrial myopathy? Other management strategies? What are the most common symptoms of mitochondrial myopathy? Who typically is diagnosed with mitochondrial myopathy? About The Speaker Dr. Bruce H. Cohen attended college at Washington University in St. Louis and a BA in chemistry, graduating summa cum laude in 1978. He received his medical degree from the Albert Einstein College of Medicine in Bronx, N.Y. in 1982 and went on to his pediatric residency at the Children’s Hospital of Philadelphia, followed by a residency in neurology at Columbia Presbyterian Medical Center in New York. He then obtained a two-year American Cancer Society fellowship in neuro-oncology at the Children’s Hospital of Philadelphia. In 1989 Dr. Cohen joined the Cleveland Clinic’s department of Neurology, and served as chief of Pediatric Neurology from 1999-2002, with joint appointments in the Clinic’s Taussig Cancer Center, the Eepartment of Neurosurgery and the department of Pediatrics. In 2011, he joined Akron Children’s Hospital in Akron, Ohio, as Director of Pediatric Neurology and then the Director of the NeuroDevelopmental Science Center. He serves in many leadership roles within Akron Children’s Hospital. His specialty interests include adult and pediatric neuro-oncology, mitochondrial medicine, neurofibromatosis, neurometabolic diseases and pediatric neurology. He has served on a number of committees for the Children’s Oncology Group, the American Academy of Neurology (AAN), the Child Neurology Society. He currently serves as chairman of the Coding Subcommittee within the Medical Economics and Management Committee of the AAN, and Secretary-Treasurer of the CNS. His past leadership positions include Chairman of the Pediatric Section of the AAN, Chairman of the Practice Com

An interview with Dr. Andrew Mammen about A novel autoantibody recognizing 200 and 100 kDa proteins is associated with an immune-mediated necrotizing myopathy, Arthritis Rheum. 2010 May 23.

A Practical Approach to the Metabolic Myopathies; Diagnosis and treatment: Glycogen Storage Myopathy by Mark A. Tarnopolsky, MD, PhD