The Lancet Respiratory Medicine

Bianca Brandon, Senior Editor at The Lancet Respiratory Medicine, is joined by Professor Hjalmar Bouma to discuss a new review on sepsis in immunocompromised patients, exploring the diagnostic challenges, complexities of immune status, and future directions for targeted therapies. The episode also analyses the increased vulnerability of specific patient groups, the importance of biomarker-driven personalised medicine, and the need for improved representation of immunosuppressed patients in clinical trials. Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00124-9/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lanresContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Deputy Editor of The Lancet Respiratory Medicine Ari Colosio discusses the critical findings of a new epidemiological study on pulmonary embolism in children and adolescents with Simon Wolf from the University Hospital of Zurich. This episode delves into the prevalence, risk factors, and clinical implications of this rare but serious condition, highlighting the need for increased awareness and further research.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00412-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Sandeep Sahay and Professor Franck Rahaghi discuss their Personal View on future treatment paradigms in pulmonary arterial hypertension.Read the full paper, Future treatment paradigms in pulmonary arterial hypertension: a personal view from physicians, health authorities, and patients, here: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00425-9/fulltextContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Il Professor Sergio Harari commenta i risultati di un trial clinico di fase 2 volto a valutare l'attivita' e la sicurezza del farmaco nintedanib come trattamento in pazienti affetti da linfangioleiomiomatosi (LAM).Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor Sergio Harari joins us to discuss the results of a phase 2 clinical trial evaluating activity and safety of nintedanib in people with lymphangioleiomyomatosis (LAM).Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Robert Kullberg joins us to discuss his Viewpoint on empiric antibiotic therapy for sepsis and the importance of reducing unnecessary use of anti-anaerobic antibiotics.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00257-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor Heather Zar joins The Lancet Respiratory Medicine to discuss early-life RSV disease and long-term respiratory health. This topic will be covered in one of four Series papers in a cross-journal Series with The Lancet.You can read the Series of papers at:https://www.thelancet.com/series/respiratory-syncytial-virus?dgcid=buzzsprout_icw_podcast_genericContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Margaux Mesle discusses estimates of lives directly saved by COVID-19 vaccination programs in the WHO European Region in the period from 2020 to 2023 and public health implications.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00179-6?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor James Hull joins us to discuss his recent Spotlight on protecting the respiratory health of athletes ahead of the Summer Olympics and Paralympics.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00183-8?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor Eric Lim discusses the outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone for pleural mesothelioma.Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Anne Chang discusses the burden of chronic respiratory diseases in Indigenous people.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00008-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor Daniel Steinfort and Professor Shankar Siva discuss the effect of systematic endoscopic mediastinal staging on radiotherapy field planning in patients with locally advanced non-small-cell lung cancer.Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Prof Daniel Prieto-Alhambra, Dr Annika Jödicke, and Dr Martí Català discuss the effectiveness of COVID-19 vaccines to prevent Long COVID, estimated to affect up to 20% of those infected with SARS-CoV-2.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00414-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Tim Nicholson and Dr Sarah Gorst discuss the development of an international Delphi consensus study on a core outcome measurement set for long COVID and how it will be used to inform future research and clinical care.Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Betty Raman discusses multiorgan MRI findings in patients after hospitalisation with COVID-19.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00262-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanresContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Keith Chappell discusses the bivalent recombinant vaccine for COVID-19 following the study by Dayan and colleagues, with focus on vaccine access, variants and boosters, tolerability and side effects, as well as hopes for future trials.Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Prof. James Chalmers discusses the characteristics of patients with bronchiectasis across Europe, the differences between countries, and possible differences in clinical outcomes, based on data from the EMBARC registry.Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00093-0/fulltext?dgcid=buzzsprout_tlv_episode-notes_general_generalContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Prof Richard Costello discusses the use of digital measurements of medication adherence and lung function to guide management of uncontrolled asthma.Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Keiju Aokage discusses segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less.Read the full article:Segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less including ground-glass opacity (JCOG1211): a multicentre, single-arm, confirmatory, phase 3 trialContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Carol Hodgson discusses recent advances in our understanding of in-hospital and post-discharge outcomes in critically ill patients who receive ECMO.Read the full article:Comparative outcomes of extracorporeal membrane oxygenation for COVID-19 delivered in experienced European centres during successive SARS-CoV-2 variant outbreaks (ECMO-SURGES)Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Emma Grainger, Editor-in-Chief of The Lancet Respiratory Medicine, discusses the January issue and plans to celebrate the 10-year anniversary of the journal. Read the Editorial from the 10th anniversary issue:Past learnings and new beginnings in the digital age

Vivienne Kahlmann and Catharina Moor discuss a study looking at online mindfulness-based cognitive behaviour treatment to address fatigue associated with sarcoidosis. Read the full article:Online mindfulness-based cognitive therapy for fatigue in patients with sarcoidosis (TIRED)

Yves Lacasse joins The Lancet Respiratory Medicine to discuss a meta-analysis on the effectiveness of home oxygen use for patients with COPD.Read the full article:Home oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis

Rachael Evans discusses the needs of people with long COVID and the latest findings from the PHOSP-COVID study.Read the full article:Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID)

Daniel Munblit and Dale Needham discuss the importance of developing a core outcome set for post-COVID-19 condition.Read the full Position Paper:A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

Daiana Stolz discusses antibiotic stewardship in patients hospitalised with pneumonia and at risk of Gram-negative bacterial infection. Read the full article:Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II)

Dr Ablo Wachinou discusses the prevalence of sleep disordered breathing in Benin and how awareness and treatment might be improved. 

Professor Peter Openshaw and Dr Felicity Liew discuss the use of inhaled corticosteroids in the early treatment of COVID and the involvement of the respiratory mucosa in response to viral infection. 

Dr Dinh Bui discusses the association between very-to-moderate preterm birth and lung function deficits and COPD at age 53.

Ruvim Izĭckson discusses the safety and immunogenicity of administering a high-dose quadrivalent influenza vaccine together with a third dose of the Moderna COVID-19 vaccine in adults aged 65 years and older.Read the full article:Safety and immunogenicity of a high-dose quadrivalent influenza vaccine administered concomitantly with a third dose of the mRNA-1273 SARS-CoV-2 vaccine in adults aged ≥65 year

Wisia Wedzicha discusses findings of a trial of a vaccine for the prevention of COPD exacerbations and provides her insights for future research.Read the full article:Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease

Eileen Rubin, author of a paper on advancing precision medicine for acute respiratory distress syndrome discusses her delayed diagnosis and how clinician and researcher goals can differ from those of patients.

Daniel Atlmann discusses the duration of immune protection from COVID vaccination and the crucial implications for the implementation of booster vaccination programmes.Read the full article:Waning immunity to SARS-CoV-2: implications for vaccine booster strategies - The Lancet Respiratory Medicine 

Comment author Michael Kreuter discusses a series of papers published in the Lancet and the Lancet Respiratory Medicine on interstitial lung disease.

Bairbre McNicholas and Jie Li discuss an open label superiority meta-trial looking at the efficacy of awake prone positioning for patients with COVID-19 acute hypoxaemic respiratory failure.  

Charles Sprung and fellow co authors Christiane Hartog, Joseph Nates, and Gavin Joynt discuss the Ethicus-II study, which looked at differences in end-of-life care in nearly 200 ICUs across 36 countries.

Christopher Brightling discusses the effect of blocking thymic stromal lymphopoietin (TSLP) with tezepelumab in patients with moderate-to-severe uncontrolled asthma.

Dr. Paul Verweij discusses a Personal View published in TLRM on COVID-19 associated aspergillosis.

Dr. Ignacio Rubio discusses a comprehensive review of the pathophysiology and phenotypes of COVID-19, the first in a Series of four papers about the pathophysiology of acute disease.

Dr. Kiran Shekar discusses a randomized controlled trial looking at cytokine adsorption in patients with severe COVID-19 pneumonia.

Dr Fan Chung discuses confronting COVID-19-associated cough and the post-COVID syndrome

Dr. Joseph Han discusses the results of the phase III SYNAPSE trial, evaluating the efficacy and safety of mepolizumab in patients with chronic rhinosinusitis

Dr. Mona Bafadhel discusses the STOIC trial, which looked at the use of inhaled budesonide in the treatment of early COVID-19.

Dr. Arvinder Soin discusses the use of tocilizumab plus standard care versus standard care alone in the treatment of moderate to severe COVID-19-associated cytokine release syndrome. 

Jordan Feld discusses the use of peginterferon-lambda in the treatment of ambulatory COVID-19 patients.

Rishi Gupta discusses a model to evaluate and predict the risk of clinical deterioration in patients with acute COVID-19

Toby Maher discusses the results of the SENSCIS trial, looking at the safety and efficacy of nintedanib in systemic sclerosis-associated interstitial lung disease (SSc-ILD) treated with mycophenolate.

Dr. Catherine Quantin discusses a new study looking at the ways severe influenza and COVID-19 are similar and differ. 

Dan Lewer of University College London discusses a modelling study that looks at housing strategies for homeless populations in the UK during COVID-19.

Dr. Anna Schultze discusses inhaled corticosteroid use in COPD and asthma patients and whether they have either a protective or harmful effect when related to COVID-19

Richard Beasley discusses a Series of three papers in The Lancet and The Lancet Respiratory Medicine that consider the promise of novel strategies to drive down the global burden of asthma.