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This week’s Pulm PEEPs Pearls episode is a focused discussion between Furf and Monty about non-pharmacologic techniques for airway clearance in the non-Cystic Fibrosis bronchiectasis population. This is a focused, high-yield discussion of the key points about airway clearance, including practical tips and a discussion of the evidence. This episode was prepared in conjunction with George Doumat MD. Goerge is an internal medicine resident at UT Southwestern and joined us for a Pulm PEEPs – BMJ Thorax journal club episode. He is now acting as a Pulm PEEPs Editor for the Pulm PEEPs Pearls series. Key Learning Points 1) Why airway clearance matters in non-CF bronchiectasis Non-CF bronchiectasis is defined by irreversible bronchial dilation with impaired mucociliary clearance, leading to mucus retention. Retained sputum drives the classic vicious cycle: mucus → infection → neutrophilic inflammation → airway damage → worse clearance. Airway clearance techniques (ACTs) are meant to interrupt this cycle, primarily by improving mucus mobilization and symptom control. 2) What ACTs are trying to achieve clinically Main benefits are: More effective sputum clearance Reduced cough/dyspnea burden Improved activity tolerance and quality of life Effects on spirometry are usually small. Exacerbation reduction is possible, but evidence is mixed—some longer-term data suggest benefit for specific techniques. 3) The main ACT “families” and when to use them Breathing-based techniques (device-free, flexible) ACBT (Active Cycle of Breathing Technique): breath control → deep breaths with holds → huffing. Pros: portable, adaptable, good first-line option. Key requirement: teaching/coaching to get technique right. Autogenic drainage: controlled breathing at different lung volumes to move mucus from peripheral → central airways. Pros: no device, can work well once learned. Cons: more technically demanding, needs training and practice. PEP / Oscillatory PEP (stents airways + “vibrates” mucus loose) PEP: back-pressure helps prevent small airway collapse during exhalation; often paired with huff/cough. Oscillatory PEP (Flutter/Acapella/Aerobika): adds oscillation that many patients find easy and satisfying to use. Good fit for: people who benefit from airway stenting, want something portable, and prefer a device. Mechanical/manual techniques (help when patient can't self-clear well) HFCWO (“the vest”): external chest wall oscillation; helpful for high sputum volumes, dexterity limits, or difficulty coordinating breathing maneuvers. Postural drainage/percussion/vibration: caregiver/therapist-assisted options; still useful but consider: GERD/reflux risk with certain positions Hemoptysis risk with vigorous techniques 4) How to choose the “right” technique (the practical framework) There is no one-size-fits-all. Match the tool to the patient: Sputum burden (volume/viscosity) Strength, coordination, cognition, dexterity Comorbidities (GERD, hemoptysis history, severe obstruction/airway collapse) Lifestyle + portability (what they'll actually do) Cost/access and availability of respiratory therapy/physio support A key mindset from the script: this is not a lifetime contract—reassess and adjust over time with shared decision-making. 5) Evidence takeaways (what improves, what doesn't) ACTs reliably improve sputum expectoration and often symptoms/QoL. QoL/cough scores (e.g., SGRQ, LCQ) tend to improve modestly, particularly with oscillatory PEP and some vest studies. Lung function: typically minimal change; occasional short-term FEV₁ benefit is reported in some vest trials. Exacerbations: mixed overall; the script highlights a longer-term RCT of ELTGOL showing fewer exacerbations at 12 months vs placebo exercises. Safety: generally excellent; main cautions are hemoptysis and reflux (depending on technique/positioning). 6) Special population pearls Hemoptysis / fragile airways: start with gentle breathing-based ACTs (ACBT, controlled huffing); avoid overly vigorous oscillatory/manual methods if concerned. Severe obstruction or early airway collapse: PEP/oscillatory PEP can help by keeping small airways open on exhalation. Mobility/coordination barriers: consider HFCWO vest or simple oscillatory PEP devices to enable daily adherence. During exacerbations: keep it simple—1–2 reliable techniques, prioritize daily consistency, and re-check technique. 7) The “real” bottom line Start with simple, self-manageable options (often ACBT ± PEP). The “best” ACT is the one the patient will do consistently. Reassess technique and fit over time; education and demonstration are part of the therapy. References and Further Reading Lee AL et al., “Airway clearance techniques for bronchiectasis,” Cochrane Database Syst Rev. 2015; PMC7175838. PMID: 26591003. Athanazio RA et al., “Airway Clearance Techniques in Bronchiectasis,” Front Med (Lausanne). 2020; PMC7674976. PMID: 33251032. Iacono R et al., “Mucociliary clearance techniques for treating non-cystic fibrosis bronchiectasis,” Eur Rev Med Pharmacol Sci. 2015; PMID: 26078380. Polverino E et al., “European Respiratory Society statement on airway clearance techniques in bronchiectasis,” Eur Respir J. 2023; PMID: 37142337. Doumat G, Aksamit TR, Kanj AN. Bronchiectasis: A clinical review of inflammation. Respir Med. 2025 Aug;244:108179. doi: 10.1016/j.rmed.2025.108179. Epub 2025 May 25. PMID: 40425105.
Breath to Breath Film that celebrates the contributions by Dr. Michael WelshA Conversation with Dr. Michael Welsh: The Science That is Saving LivesIt's always such a privilege to feature CF icons on the podcast. Over the years, we've been fortunate to host some of the most influential names in cystic fibrosis research, including Dr. Francis Collins, the former director of the NIH and one of the authors of the Human Genome Project, and his longtime friend Dr. Mitch Drumm, who was working on his doctorate when the CF gene was discovered back in 1989.I actually saw Mitch recently at a dinner, and as many of you know, Dr. Collins continues to be a tireless advocate for good science and for sharing its importance with the world.And now, we add another legend to that list: Dr. Michael Welsh from the University of Iowa.Dr. Welsh tells his story beautifully in the University's film Breath by Breath: Living with Cystic Fibrosis. In it, he describes how his curiosity about the CFTR protein led to groundbreaking discoveries that ultimately laid the foundation for CF therapies, the very treatments that have changed (and saved) thousands of lives, including the lives of my daughters.Dr. Welsh's career is extraordinary, spanning decades of research, mentorship, and discovery. He's the Carver Professor of Internal Medicine and Molecular Physiology and Biophysics at the University of Iowa, and from 1989 to 2024, he served as an Investigator with the Howard Hughes Medical Institute. He currently directs both the Pappajohn Biomedical Institute and the Cystic Fibrosis Research Center.We've linked both his full bio and the film in the show notes, and I highly encourage you to check them out. His accolades could fill pages, actually, an entire book! We had so many laughs too in this podcast! So much fun. You'll really enjoy it.Dr. Welsh shared insights not only into his scientific journey, but also the heart behind the work. He recently received the Lasker Award for pioneering CF research that led to life-saving therapies, a recognition that celebrates decades of persistence, curiosity, and collaboration.We discussed so much:How his team began unraveling the mystery of the CFTR protein and what that breakthrough moment felt likeWhat it's like to see patients thriving because of the treatments that grew from that workWhy the University of Iowa decided to produce Breath by Breath, and what the film means to him personallyWhat new treatments and discoveries he's exploring nowHearing Dr. Welsh describe the intersection of science, hope, and humanity is powerful. You can tell that for him, this work isn't just research, it's a mission.As the documentary shows, CF isn't just a disease studied under a microscope. It's a lived experience for patients and families, one that now includes real hope thanks to the breakthroughs made by scientists like Dr. Michael Welsh.Biography:Dr. Michael Welsh is the Carver Professor of Internal Medicine and Molecular Physiology andBiophysics at the University of Iowa. From 1989-2024, he was an Investigator of the HowardHughes Medical Institute. He directs the Pappajohn Biomedical Institute and the Cystic FibrosisResearch Center.Dr. Welsh obtained an MD and completed an internal medicine residency at the University ofIowa. He then trained in pulmonary medicine and research at the University of California, SanFrancisco and physiology at the University of Texas, Houston.Dr. Welsh and his colleagues discovered that the protein affected in cystic fibrosis is an anionchannel, elucidated its functional mechanisms, discovered ways that mutations disrupt function,and showed that mutations can be rescued. This work led directly to development of medicinesthat target CFTR and are highly effective for most cystic fibrosis patients. To understand diseasepathogenesis, he and his collaborators developed cystic fibrosis pigs, the first mammal, otherthan mice, in which a gene was targeted to generate a disease model.His clinical activities focused on pulmonary diseases. He has trained many physicians andscientists and received the Distinguished Mentor Award, University of Iowa Carver College ofMedicine.To watch the film, click here: https://uihealthcare.org/cystic-fibrosis-research-iowa#documentaryTo learn more about Dr. Welsh: https://internalmedicine.medicine.uiowa.edu/profile/michael-welsh Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Beyond the Pearls: Cases for Med School, Residency and Beyond (An InsideTheBoards Podcast)
Today's Case A 30-year-old nulliparous Caucasian woman comes in for her routine gynecology appointment. She tells you that she would like to discontinue her birth control as she and her partner are planning to become pregnant in the next year. The patient says that one of her family members has cystic fibrosis (CF). Today's Reader Dr. Kada Fehlman is an Internal Medicine Resident at Huntington Health Cedars-Sinai. About Dr. Raj Dr Raj is a quadruple board certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctors for the past 7 seasons and has a weekly medical segment on ABC news Los Angeles. More from Dr. Raj The Dr. Raj Podcast Dr. Raj on Twitter Dr. Raj on Instagram Want more board review content? USMLE Step 1 Ad-Free Bundle Crush Step 1 Step 2 Secrets Beyond the Pearls The Dr. Raj Podcast Beyond the Pearls Premium USMLE Step 3 Review MedPrepTGo Step 1 Questions MedPrepTGo Step 2 Questions Learn more about your ad choices. Visit megaphone.fm/adchoices
How is cystic fibrosis diagnosis evolving? In this second deep dive, Nicholas Simmonds explores advances in diagnostic tools and shares his experience with the CF registry, highlighting its value as a powerful resource for tracking long-term treatment effectiveness. A must-listen for clinicians and anyone interested in how cystic fibrosis is diagnosed, and how progress is monitored over time. Timestamps: 00:00 – Introduction 00:52 – Adulthood diagnosis 06:00 – Advanced diagnostics 10:37 – Survival variability 15:05 – CF Registry
In this third and final deep-dive episode, Nicholas Simmonds highlights the importance of collaborative networks, such as the European Cystic Fibrosis Society (ECFS) Clinical Trials Network, in enabling global clinical trials. He also emphasises the central role of the patient voice in developing new therapies, using CFTR modulators as a key example. Timestamps: 00:00 – Introduction 00:55 – ECFS Network 03:29 – Trial design 04:54 – Therapy frontiers 07:48 – Curative approaches 13:07 – Clinician message
In this rapid-fire episode, Nicholas Simmonds answers key questions about cystic fibrosis (CF), from common misconceptions and the value of registry data to CF testing, and the transition from paediatric to adult care. Perfect for listeners short on time.
Nicholas Simmonds joins host Saranya Ravindran for a deep dive into how adult cystic fibrosis (CF) care is evolving. Drawing on decades of experience, he discusses the major shifts in adult CF management, the vulnerable transition from paediatric to adult services, and strategies that ensure a smooth handover. Explore how longer survival brings new challenges, from fertility to mental health and emerging comorbidities, and why continuity of multidisciplinary care is more crucial than ever. Timestamps: 00:00 – Introduction 01:15 – Adult care 04:12 – Smooth handover 10:10 – Evolving needs
There have been great advances in the treatment of cystic fibrosis, but nevertheless it remains a progressive, life‑shortening genetic disease as many patients still don't reach normal function and continue to face infections, exacerbations, and impaired quality of life. Siona Therapeutics is building a new generation of small‑molecule therapies that directly stabilize the region most affected by the most common mutation underlying the disease for the roughly 90 percent of patients who carry the defect. We spoke to Mike Cloonan, CEO of Sionna, about its experimental therapy that stabilizes the misfolded protein at the heart of the disease, its exploration of combination therapies with existing and proprietary therapies, and its $219 million IPO in February, despite the difficult financing environment for development-stage biotechs.
How can the threat of antimicrobial resistance be mitigated? In this second deep-dive episode, Lisa Saiman shares insights into the value of antibiotic stewardship and the nuance of microbial susceptibility testing in patients with cystic fibrosis. A must-listen for anyone curious about the overlap between cystic fibrosis and pathogen resistance. Timestamps: 00:00 – Introduction 03:30 – Antimicrobial resistance threat 04:20 – Antibiotic stewardship 07:00 – Hospital lessons 10:00 – New antimicrobials
In the final instalment of this episode on paediatric cystic fibrosis, Lisa Saiman explores the global inequities that persist, noting how progress is hindered by limited access to advanced antimicrobial resistance prevention tools such as sequencing and pathogen identification. She emphasises the need for strengthened international collaboration to help bridge these gaps. Timestamps: 00:00 – Introduction 00:56 – Care inequities 03:30 – Global lessons 07:08 – Global collaborations 08:56 – Future directions
Thomas English talks with a guest from Wrapping For A Cure in Nevada about their holiday wrapping initiative. The guest is Denna Archer. She discusses the origins of the initiative and how Cystic Fibrosis has affected her family. She also discusses how the Wrapping For A Cure program works and how residents can take advantage of it. Other topics include how to donate and other ways to get involved.
Lisa Saiman joins host Saranya Ravindran to discuss infection prevention in children with cystic fibrosis, exploring evolving hospital and clinical practices, key respiratory pathogens, and practical strategies to reduce infection risk at home. Learn about how the risk of infection affects the day-to-day lives of patients with cystic fibrosis. Timestamps: 00:00 – Introduction 01:05 – Prevention importance 04:34 – International management 05:58 – Cross-infection risk 06:55 – COVID-19 lessons 07:43 – Home risk 10:57 – Childhood pathogens
In this rapid-fire episode, Lisa Saiman answers key questions about infections in children with cystic fibrosis, from everyday prevention measures to the threat of antimicrobial resistance. Perfect for listeners short on time but eager to boost their paediatric cystic fibrosis knowledge in just a few short minutes.
Landon Carpenter is a volunteer in Blue student ministry. He sits down with Noisy Narratives to talk about how he met his wife, what it means to love and partner with a spouse with Cystic Fibrosis, and how he feels God prepared him for their life. Landon's perspective is encouraging and his story is a testament to God's faithfulness. Landon's wife, Angela, shared her story in an earlier season - you can listen here.PROGRAM NOTE - please pardon the audio issues during the intro. Equipment problems created some challenges - but we will have them fixed for next week. The interview audio is good!
This Giving Tuesday, we have a special episode of the ATS Breathe Easy podcast. Wildfires are a destructive phenomenon that decimates communities, infrastructure, and wildlife. But wildfires and wildfire smoke are also severely damaging to human health, especially for those who have lung disease. Stacie Reveles, of the Cystic Fibrosis Research Institute, talks about her struggles living in wildfire country with a child who has cystic fibrosis. She discusses everything from dealing with medications and evacuations, the mental toll, and the importance of continued research into these illnesses. Air Health Our Health podcast creator Erika Moseson, MD, MA, of Legacy Health in Oregon hosts. Donate to the ATS Research Program today to help families like Stacie's: https://aeugmntn.donorsupport.co/page/Stacie The ATS Wildfire Disaster Guidance sheet: https://www.thoracic.org/patients/patient-resources/resources/wildfires.pdf Listen to the Our Health in Wildfire Season episode of Air Health Our Health for how to prepare your home and community: https://creators.spotify.com/pod/profile/airhealthourhealth/episodes/Our-Health-in-Wildfire-Season-e162en9/a-a2ata11
Asthma and COPD may be the ‘bread and butter' of the respiratory conditions seen in primary care, but other respiratory conditions, such as bronchiectasis, will also be seen. In this episode of the MIMS Learning Clinical Update podcast, MIMS Learning editors Dawn and Pat survey the wide range of respiratory conditions seen in primary care that are not COPD or asthma. They look at the diagnosis of bronchiectasis, improvements in managing cystic fibrosis, the rising incidence of tuberculosis (TB), and how the NHS Lung Cancer Screening Programme is enabling earlier diagnosis.Educational objectivesAfter listening to this podcast, healthcare professionals should be better able to: Describe the pathophysiology of bronchiectasisReview how developments in screening and management has improved outcomes in cystic fibrosisDiscuss which socioeconomic groups are at increased risk of tuberculosisRecall the number of lung cancers detected through the NHS lung cancer screening programmeYou can access the website version of this podcast, along with a list of key learning points, on MIMS Learning - and make notes for your appraisal. MIMS Learning offers hundreds of hours of CPD for healthcare professionals, along with a handy CPD organiser.Please note: this podcast is presented by medical editors and discusses educational content written or presented by doctors, nurses and other healthcare professionals on the MIMS Learning website and at live events.MIMS LearningSubscribe to MIMS LearningBronchiectasis: clinical reviewCystic fibrosis: clinical reviewInflammatory bowel disease mimicsLung cancer: presentation and referralPodcast: advanced nurse practitioner Beverley Bostock on asthma and COPDPodcast bonus episode: Dr Steve Holmes on asthma in pregnancy and childhood wheezeMIMSEarly start to flu season prompts warning for healthcare professionalsInfluenza vaccines 2025/2026Influenza vaccines, which vaccine to offer Hosted on Acast. See acast.com/privacy for more information.
She was given a "use by date" of 12 years old.In this episode I sit down with Tayla to chat about the reality of living with Cystic Fibrosis. (I had no idea what it really was) We get into the "invisible" struggles that you'd never see just by looking at her, the time her sweat turned into actual salt crystals in her soccer gear (wild), and the groundbreaking drug trial that changed her life right when things were looking their worst. Plus, we bond over my theory that humans are basically just used cars waiting for a mechanic, and she teaches me that sometimes, a dark sense of humour is the best survival mechanism you can have.You can support Tayla's fundraising efforts here: https://www.breakasweat.com.au/tayla-purves And if you enjoy this episode, feel free to leave a comment - or maybe rate the podcast if you haven't done so yet? Thanks heaps!!Wanna check out all things Podvan? ⬇️Facebook | Instagram | FB Group | Podvan Website | YouTube | TikTokThis is a Podvan Media production.
CME in Minutes: Education in Rheumatology, Immunology, & Infectious Diseases
Please visit answersincme.com/KUS860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in pulmonary medicine discusses the treatment of patients with non–cystic fibrosis bronchiectasis (NCFB) using dipeptidyl peptidase 1 (DPP1) inhibitors. Upon completion of this activity, participants should be better able to: Recognize the rationale for targeting neutrophilic inflammation in non–cystic fibrosis bronchiectasis (NCFB); Describe the clinical impact of DPP1 inhibitors for treating NCFB, in the context of conventional therapy; Outline strategies to individualize the selection of neoadjuvant, adjuvant, or perioperative immunotherapy approaches for patients with resectable stage IIB/C and stage III/IV melanomaApply strategies to enhance outcomes for patients with NCFB as the treatment landscape evolves; and Apply strategies to enhance outcomes for patients with NCFB as the treatment landscape evolves.
Please visit answersincme.com/KUS860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in pulmonary medicine discusses the treatment of patients with non–cystic fibrosis bronchiectasis (NCFB) using dipeptidyl peptidase 1 (DPP1) inhibitors. Upon completion of this activity, participants should be better able to: Recognize the rationale for targeting neutrophilic inflammation in non–cystic fibrosis bronchiectasis (NCFB); Describe the clinical impact of DPP1 inhibitors for treating NCFB, in the context of conventional therapy; Outline strategies to individualize the selection of neoadjuvant, adjuvant, or perioperative immunotherapy approaches for patients with resectable stage IIB/C and stage III/IV melanomaApply strategies to enhance outcomes for patients with NCFB as the treatment landscape evolves; and Apply strategies to enhance outcomes for patients with NCFB as the treatment landscape evolves.
What defines excellence in cystic fibrosis clinical care? Peter Mogayzel discusses the latest therapeutic guidelines, managing pulmonary exacerbations, the role of home monitoring, and how multidisciplinary teams work together to support patients in leading full, active lives. Timestamps: 00:00 – Introduction 00:41 – Key guidelines 01:54 – Multisystem disease 02:32 – Pulmonary exacerbations 04:04 – Chronic medications 05:37 – Home monitoring 08:15 – Multidisciplinary care
From CFTR modulators to gene therapy, what's next in cystic fibrosis research? Peter Mogayzel examines future therapies, ongoing access challenges, and the crucial link between advocacy, innovation, and global health equity in cystic fibrosis care. Timestamps: 00:00 – Introduction 01:05 - CFTR modulators 03:35 – Anti-inflammatory drugs 04:18 – mRNA therapy 04:53 – Side effects 07:13 – Access to care 08:37 – Exercise 10:00 – Final thoughts
Delivering Hope across Continents. The why and how Summer Bauder got involved with CF Vests Worldwide.Summer Bauder is a remarkable woman whose story embodies compassion, perseverance, and global impact.Summer's journey began as a stay-at-home mom managing a bustling household a life filled with love, chaos, and purpose. But everything changed when her brother-in-law's daughter was diagnosed with cystic fibrosis (CF). What started as a family connection to CF grew into a calling that now spans continents.Today, Summer serves as a key volunteer for CF Vest Worldwide, a nonprofit that provides life-changing airway clearance vests to people with CF who can't afford them. Her days are filled with cleaning, sorting, and shipping donated vests to families across the globe, and sometimes, personally delivering them.From India to Colombia to Ecuador, Summer has met families whose gratitude reminds her daily why this work matters. She shares powerful, heartwarming moments, like watching a child take easier breaths for the first time, and the challenges of navigating logistics, language barriers, and limited resources.Next up? Honduras, where Summer delivers 10 vests to families in need.Balancing her large family and international volunteer work hasn't been easy, but Summer says her experiences at home prepared her for the organizational and emotional demands of this mission. Her story is a reminder that one person — one family — can make a global difference.This episode shines a light on the power of community, family support, and the ripple effect of kindness.If you'd like to support Summer's efforts, CF Vest Worldwide is currently accepting donations of child-sized garmentsused to distribute vests to children with CF around the world.What's her connection? Her why? It's her brother, Josh Bauder.To see more about Summer's work, watch her video: https://youtu.be/sHSB9kIp060To contact CFVWW: rod@cfvww.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
In this quickfire introduction, Peter J. Mogayzel answers fast questions about the evolution of cystic fibrosis care in the USA, from early screening and survival milestones to innovation, policy, and equitable access. A perfect primer on where cystic fibrosis care stands today.
How did the USA build one of the world's most comprehensive cystic fibrosis care systems? In Part 1 of our deep dive, Peter Mogayzel explores the development of national cystic fibrosis centres, the impact of newborn screening, and how a strong foundation in care standards transformed outcomes across generations. Timestamps: 00:00 – Introduction 01:38 – Care models 02:40 – Early screening 04:20 – CF Foundation 05:33 – What's changed?
Jennifer McKinnon is fierce. Doctors said Jennifer wouldn't live past the age of three.Today, she's a single mom of twins, an unstoppable advocate who's raised over a million dollars for cystic fibrosis research, and the founder of Just One More Breath. Her story is proof that while CF is tough, Jennifer is tougher, and that hope, when held fiercely, can change everything.Jennifer was born in the 1970s with cystic fibrosis, a time when the disease was still cloaked in uncertainty and fear. Few children with CF lived to see adulthood, and the treatments that exist today were still decades away. From the very beginning, every breath she took was a small act of defiance. Hospital rooms became her playgrounds, IV poles her silent companions, and the steady rhythm of nebulizers the soundtrack of her childhood.But even in those sterile rooms filled with machines and medicine, Jennifer's spirit burned bright. She refused to let CF define her — or defeat her. Through endless hospital stays, setbacks, and the exhausting daily grind of treatments, she found reasons to laugh, to dream, and to keep fighting. Every milestone, every birthday, every deep breath, became a victory.Then came 2019, a year that would rewrite her story once again. With the arrival of Trikafta, the groundbreaking CF modulator, Jennifer's world shifted. Suddenly, life felt lighter — her lungs stronger, her body more capable. For the first time, she could picture a future not limited by her disease but expanded by possibility. She could plan, imagine, and live, truly live, in ways she once only dreamed of.Yet Jennifer's story isn't just about survival; it's about transformation. Rather than turning inward, she turned outward — channeling her strength into action. She's raised over a million dollars for cystic fibrosis research, driven by the belief that every dollar brings us closer to a cure. She became a mother to twins through the extraordinary gift of her sister, proving that family and love can find a way even when the odds seem impossible.Today, Jennifer stands as a single mom, a tireless advocate, and the voice behind Just One More Breath, a platform dedicated to raising awareness, sharing stories, and inspiring others to keep pushing forward ... one breath at a time.Her journey is a powerful reminder that life with cystic fibrosis is unpredictable, yes, but it is also breathtakingly beautiful. It's a life lived with intention, courage, and grace. Jennifer's story teaches us that even when the odds seem insurmountable, resilience can turn pain into purpose, and hope can carry you through the darkest storms.Because for Jennifer, every breath is more than survival.It's a celebration of strength, of love, and of the limitless power of the human spirit.Jennifer on IG: https://www.instagram.com/just.onemorebreath/?hl=enWebsite: https://jennifer-mckinnon.com/? Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
This is Part 2 of Josh and Amy Glasscock's story. We'll hear how Josh's cystic fibrosis has worsened and irreparably damaged his lungs. Soon, they'll be confronted with several life and death decisions. Only God will be able to carry them through the storms ahead. Listen to Part 1 in Episode #38 "Chronically Sick. Abundantly Alive. - Josh & Amy Glasscock, Part 1" Show notes: https://compelledpodcast.com/episodes/josh-amy-glasscock-pt-2 ++++++++++++ Compelled is a seasonal podcast using gripping, immersive storytelling to celebrate the powerful ways God is transforming Christians around the world. These Christian testimonies are raw, true, and powerful. Be encouraged and let your faith be strengthened! Want to help make new episodes? Either make a one-time gift, or become a Monthly Partner at: https://compelledpodcast.com/donate Perks of being a Monthly Partner include: EARLY ACCESS to each new Compelled episode 1 week early! FULL LIBRARY of our unedited, behind-the-scenes interviews with each guest... over 100+ hours of additional stories and takeaways! Become a Monthly Partner by selecting the "Monthly" option during check-out. Show notes, emails, and more at: https://compelledpodcast.com Buy the Compelled book of testimonies, endorsed by Lee Strobel, Marvin Olasky, and more: https://compelledpodcast.com/book Compelled is a member of the Proclaim Podcast Network: https://proclaim.fm Learn more about your ad choices. Visit megaphone.fm/adchoices
Send us a textJohnny and BW talk a bit about last weeks SEC win against Arkansas and preview this weeks game against the Georgia Bulldogs. Then they are joined by Memphis' Action News 5 Anchor Joe Birch. Joe helps support the Cystic Fibrosis foundation and many other local philanthropies in Memphis. He talks a bit about how he ended up in Memphis and ultimately became a news anchor for channel 5. He also discusses his involvement with the St. Jude Marathon. Help support our cause to raise money for Cystic Fibrosis research by ordering a fresh roasted bag of coffee from Johnnypacker.netSupport the show
The Triple Threat to the Rare Disease Ecosystem — A Conversation with Dr. Wendy ChungSometimes you come across someone whose work changes the way you think about an entire field. That's exactly what happened when I read about Dr. Wendy Chung in Rare Revolution Magazine.Dr. Chung is one of those rare people who stands at the intersection of science, medicine, ethics, and humanity. She's a clinical and molecular geneticist, the Chief of Pediatrics at Boston Children's Hospital, and the Mary Ellen Avery Professor at Harvard Medical School. She leads NIH-funded research into the genetics of conditions like pulmonary hypertension, autism, birth defects, and a wide range of rare diseases. She's advanced newborn screening for life-threatening disorders like spinal muscular atrophy and Duchenne muscular dystrophy — work that means the difference between life and death for many families. She's been recognized with the Rare Impact Award from NORD, is a member of the National Academy of Medicine, and is a leading voice on the ethics of genomics.But titles and accolades only tell part of her story. What stands out most is her deep commitment to the people behind the science, the families living day in and day out with conditions that most of the world has never heard of.When we spoke, Dr. Chung described what she calls the “triple threat” to the rare disease ecosystem:Misinformation in health that spreads faster than facts and erodes trust in science.Lack of access to healthcare, leaving too many without the treatments they need, when they need them.Insufficient investment in research, slowing the pace of discovery and delaying life-saving therapies.Each of these challenges is daunting on its own, but together they create a fragile and often hostile environment for progress in rare disease research and care.She pointed out that while most genetic conditions are rare individually, collectively they are surprisingly common — affecting millions worldwide. That's a staggering thought, especially considering how little public awareness and funding rare diseases often receive.We also talked about autism, a condition she has studied extensively. She emphasized that autism is a spectrum, with multiple causes, the majority of which are genetic. Understanding that complexity is crucial, not only for advancing science but also for helping families cope and make informed decisions.One of the threads running through our conversation was the urgent need for better communication in science. In an age where misinformation spreads in seconds, the ability to convey facts clearly and accessibly isn't just a nice skill — it's a necessity. Miscommunication or confusion doesn't just impact public opinion; it influences policy decisions, research funding, and the direction of healthcare itself.Dr. Chung stressed that advocacy matters at every level — from the conversations parents have with their children's doctors to the policies shaped in Washington. Community engagement isn't just a feel-good idea; it's one of the most effective ways to accelerate progress. Patients, families, scientists, and policymakers all have a role to play, and collaboration among them is where breakthroughs happen.In the end, our conversation left me with two truths. First, that rare disease progress depends on persistence from so many people. The researchers who refuse to give up, from families who continue to fight for answers, and from advocates who push for change. Second, that truth itself is a kind of medicine. The more accurately, compassionately, and consistently we can communicate about rare diseases, the better chance we have at building a healthcare ecosystem that works for everyone.Dr. Wendy Chung is leading that charge, not just in the lab, but in the public square. And in this fight, both matter equally. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
What's it like getting pepper-sprayed when you have a chronic lung disease? A homicide detective knows what's up. This week, we sit down with a guest who defies expectations: Jeremy, a homicide detective living with Cystic Fibrosis (CF). We dive into the unique challenges and surprising advantages of managing a demanding, high-stress career alongside a chronic illness. He opens up about the progression of his CF, the profound impact of the life-changing drug Trikafta, and his perspective on life expectancy before and after the medication. You can watch this entire episode over on YouTube.Follow Sickboy on Instagram, TikTok and Discord!
What's it like getting pepper-sprayed when you have a chronic lung disease? A homicide detective knows what's up. This week, we sit down with a guest who defies expectations: Jeremy, a homicide detective living with Cystic Fibrosis (CF). We dive into the unique challenges and surprising advantages of managing a demanding, high-stress career alongside a chronic illness. He opens up about the progression of his CF, the profound impact of the life-changing drug Trikafta, and his perspective on life expectancy before and after the medication. You can watch this entire episode over on YouTube.Follow Sickboy on Instagram, TikTok and Discord!
When Pete Proimos decided to share his cystic fibrosis story at 40, after decades of silence , it marked a turning point. That decision, guided by his philosophy “Out at 40,” sparked a movement built on honesty, empathy, and empowerment.Today, as CEO of the Filotimo Foundation, Pete is redefining what it means to thrive with an invisible illness and helping others find strength in their own stories.Pete is a tireless advocate for people living with cystic fibrosis. Diagnosed at birth, Pete has spent his life navigating the challenges of CF—while rewriting the narrative of what it means to truly thrive with a chronic, invisible illness.Through the Filotimo Foundation, Pete has built a strong network of support for individuals and families—while breaking down the stigma surrounding conditions you can't always see.Whether you live with CF, love someone who does, or simply care about creating a more compassionate world, Pete's story will inspire you.To learn more about Pete's Foundation; https://filotimofoundation.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Our guest this week is a hard-charging Kauai'an, known for paddling into any death pit at Pipe and chasing XXL swells across the globe. His résumé is stacked, winning the Pipeline Invitational in 2014 earning a coveted Pipe Masters wildcard, and taking the crown at the prestigious Da Hui Backdoor Shootout with a $30K payday! Also being awarded “Wave of the Decade” in 2020, add to that multiple “Wave of the Winter” and “XXL Big Wave Award” nominations, it's clear he earned his place as a Big Wave Warrior!But if there's one moment that etched his name into surfing history and mainstream headlines, it was the wild Teahupoo incident when the jet ski he was driving went over the falls, literally launching over the head of Big-Wave Legend Raimana Van Bastolaer. A viral clip that lit up Social Media, covered by Sports Illustrated and major news outlets worldwide.Beyond charging slabs, he's managed the Quiksilver North Shore Athlete House for the last decade, and has the passion and dedicates time to giving back supporting those battling Cystic Fibrosis.We're honored to welcome to the show a true Hawaiian charger and legend of our sport, Reef “BIG CAT” McIntosh!
Coverage that provides news and analysis of national issues significant to regional Australians.
Australian taxpayers will fund a multi-million dollar rescue package for mining giant Glencore to keep copper processing facilities operating in Queensland until the end of 2028.
Turning Diagnosis into Purpose: Deana and Liam's MissionWhen Liam was diagnosed with cystic fibrosis (10 years ago) at just three weeks old, Deana's world shifted overnight. What began as one mother's fight for her child has grown into a movement empowering families, educators, and kids facing chronic illness, all through courage, creativity, and hope.From bestselling advocacy workbooks to emotional wellness initiatives, Deana and Liam are transforming personal challenges into meaningful change. You'll hear how storytelling became their most powerful tool, and why their message, hope is louder, is resonating far beyond the CF community.In this episode, we talk about:How The Ultimate CF Family Workbook came to lifeThe importance of storytelling in chronic illnessTheir upcoming children's book and animated series, Liam's ChroniclesHow they're changing the conversation around invisible illnessLearn more about their work or grab a workbook: [Insert Website or Linktree]Available on Amazon + EtsyFeatured by hospitals like SickKids and CHEOConnect with Deana & Liam:FB: Facebook.com/liamsmission00To order: www.liamsmission.ca IG: Instagram.com/liamsmission Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Men's mental health is still one of the hardest conversations to have, both at work and at home. Despite all the progress in recent years, too many men continue to stay silent, with devastating consequences. In this episode, I'm joined by Tim Wotton, who's faced more challenges than most, living with cystic fibrosis and type 1 diabetes, and yet has built a life defined by resilience, discipline and hope. Tim shares what he's learned about strength, survival, and why it's time we change the way men are supported to talk about their mental health.Highlights:(05:03) Why silence is still mistaken for strength(11:37) Tim's ‘power of three' resilience philosophy(18:18) Discipline as the unglamorous key to survival(27:43) The unseen struggles hidden behind a smile(36:11) Why men still fear showing vulnerabilityFind out more:Paul McGee The SUMO Guy (Shut Up and Move On)‘How Have I Cheated Death? A Short and Merry Life with Cystic Fibrosis' by Tim Wotton HERE and HERE.Take the Aurora 360 Quiz: How Effective Is Your Company's Wellbeing Strategy? Click HereConnect with us here:Website: aurorawellnessgroup.co.ukLinkedIn: NgoziLinkedIn: ObehiAurora Company Profile 2024Book a Call here
Beat Migs! And we talk all about climbing the stairs of T-Mobile Park for Cystic Fibrosis! Plus we go Straight to the Comments about the crazy catch Victor Robles made over the weekend!
The unstoppable Jennifer Dunlea is an advocate, a fighter, and an all-around powerhouse. Born with Cystic Fibrosis, Jen has faced more medical battles than most people do in a lifetime, including surviving a rare cancer at just 23 years old. She's a two-time double lung transplant recipient, living with diabetes and gastroparesis, and still somehow finds the energy to raise her voice, and awareness, for the CF and transplant communities every single day. You might know her from social media, where she shares her journey with honesty, humor, and heart under the handle @jencantbreathe on TikTok, Instagram, YouTube, and Facebook.Trust me, you're going to be inspired by this conversation.To follow Jen: @jencantbreatheCOTA health fundraising campaign: https://cota.org/cotaforjenslungs/our-story/The Sick Chick Hour: https://open.spotify.com/show/7eegd1SwLueAnrxueC7VVeYoutube for Jen: https://youtube.com/@jencantbreathe?si=QXrvZniAYTwjmv2v Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
The challenges and triumphs of living with a rare disease. Leslie Baldwin shares her personal journey with Common Variable Immune Deficiency and Ehlers-Danlos Syndrome. You'll hear what fueled her passion for advocacy and the creation of Michigan Rare (MI-RARE). Together, they discuss the power of community, the importance of patient empowerment, and how collaboration with policymakers can expand access and resources for those living with rare conditions.TakeawaysAdvocacy is essential for the rare disease community.Building connections provides vital support.Patients should feel empowered to speak up for their health.Collaboration with policymakers can drive positive change.Storytelling inspires and unites the community.Engagement raises awareness and strengthens support networks.Advocacy days introduce rare disease issues to lawmakers.Recognizing unique challenges leads to better understanding.Coalitions amplify the collective voice of rare disease advocates.Empowering patients and caregivers enhances quality of life.About Leslie BaldwinA Michigan native now living in Holt, Leslie is a rare disease advocate. She co-founding MI-RARE, a foundation uniting rare disease voices across Michigan, alongside Kayla Miller, Kathi Luis, Kortney Lee, Chris Draper, and Laura Bonnell.Her advocacy experience is wide-ranging: she has worked with Autism Speaks, National Organization for Rare Disorders (NORD), The EveryLife Foundation, NIH, CMS, and the FDA. As Director of Strategic Advancement with Texas Rare Alliance, she helped pass key legislation that earned her national recognition as a finalist for the 2023 Rare Voice Award in State Advocacy.On September 30th, MI-RARE will host the Michigan Rare Disease State Advocacy Day at the Capitol, a powerful opportunity for patients, families, and caregivers to share their stories with lawmakers and demonstrate that while each condition may be rare, together we are many.To connect go to: MI-rare.org Register for Advocacy Day opens August 4th and ends September 12th, 2025. There is a travel stipend too. Go to the MI-Rare website.To connect with Leslie Baldwin: leslie@mi-rare.org Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Send us a textJohnny and BW recap the Bulldog's victory over Arizona State last week. Bulldog sideline reporter Jay Perry joins Johnny and shares some fun stories from times spent with Dan Mull, Mike Leach and other Bulldog coaches. He talks about being on the sideline for last weeks win over Arizona State and talks about the rest of the season. To support our mission to raise funds and awareness for the Cystic Fibrosis foundation be sure to go to Johnnypacker.net and order a fresh bag of coffee. Support the show
Pulmonologist Michael J. Welsh, MD, is the co-recipient of the 2025 Lasker-DeBakey Clinical Medical Research Award for his research on cystic fibrosis. In this interview, he discusses his early clinical encounters with the disease, the foundational work that led to the lifesaving drug Trikafta, and future directions for cystic fibrosis treatment. Related Content: How Cystic Fibrosis Went From Fatal to Treatable Rewriting the Chapter on Cystic Fibrosis
Miss America 2025 Abbie Stockard: A Champion for Kids, Health, and Cystic FibrosisAbbie Stockard, Miss America 2025, joins us to share her incredible journey, from Auburn University nursing student and Tiger Paws dancer to national advocate and role model. At just 22, Abbie has earned over $89,000 in scholarships through the Miss America Opportunity and is using her platform to promote pediatric health, women's leadership, and awareness for cystic fibrosis (CF).Inspired by her best friend Maddie, Abbie has raised over $200,000 for CF research and was honored as the Cystic Fibrosis Foundation's “2024 Hero of Hope.” She also created High Five for Kids, a wellness program that empowers children—including those with chronic illnesses, to build healthy habits for life.In this episode, Abbie talks about balancing school, service, and advocacy, and how she's using her voice to drive real change in healthcare and beyond. Don't miss this inspiring conversation with a young woman leading with heart, purpose, and unstoppable energy. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
In this deeply moving and inspiring episode of the Tough Girl Podcast, we're joined by Sophie Pierce, a 32-year-old social worker from Pembrokeshire, West Wales, who made history in March 2025 as the first person with Cystic Fibrosis to row an ocean. Diagnosed at just 3 months old, Sophie has lived with the challenges of a genetic condition that affects her lungs and digestive system and once carried a life expectancy of under 30 years. But Sophie's story is not defined by limitation—it's a bold testament to resilience, courage, and the power of hope. From working in fostering services to hiking the Welsh coast with her dogs, swimming in cold water, and sleeping in her campervan—Sophie has never shied away from living life on her terms. In this episode, she opens up about the life-changing impact of the Kaftrio drug trial, how she overcame mental health struggles, and what it truly meant to embrace life beyond the horizon by rowing across the Atlantic. She shares the highs and lows of the row: the months of preparation, team dynamics, magical moments at sea, and how it feels to return to "normal life" after an extraordinary adventure. Sophie's message is powerful and universal—you are capable of so much more than you think. If you're looking for inspiration, perspective, and an honest exploration of living—and thriving—with a life-limiting condition, this episode is not to be missed. New episodes of the Tough Girl Podcast drop every Tuesday at 7 AM (UK time)! Make sure to subscribe so you never miss the inspiring journeys and incredible stories of tough women pushing boundaries. Do you want to support the Tough Girl Mission to increase the amount of female role models in the media in the world of adventure and physical challenges? Support via Patreon! Join me in making a difference by signing up here: www.patreon.com/toughgirlpodcast. Your support makes a difference. Thank you x Show notes Who is Sophie 32 years old Living in Pembrokeshire, West Wales Working as a social worker in fostering service Living with a genetic health condition - Cystic Fibrosis (CF) March 2025 - becoming the first person with CF to row an ocean What is CF Being born with it and getting diagnosed at 3 months old Having a shorter lifespan How CF affects her lungs and digestive system Living with reduced lung function Her younger years and how she was treated Why exercise and being out in the fresh air is actively encouraged Not liking exercise as a child Growing up knowing she had CF and why it was normal Being empowered with CF and how her parents encouraged her Her mum reminding her to stay as well as she could for as long as she could, so she could benefit from treatments in the future. Learning about her shorter life expectancy and managing those feelings Adopting a positive attitude - being determined to live her life and not letting CF hold her back Wanting to make the most of her time Understanding that time is precious Not needing a pension, savings or need to put down roots The help and support available to help manage the mental and emotional challenges Experiencing panic attacks while her health was declining Working with a psychologist Using tools from Acceptance and Commitment Therapy (ACT) Feeling frightened of letting the big feelings of sadness in Feeling so sad about living with CF The drug trial - 5 years ago Taking the Kaftrio drug The challenges of winter for CF patients ‘The Purge' - coughing for 24 hrs How her life and lungs has changed Trustee for CF Trust Being asked to row an ocean Forming a crew of 4 Stumbling blocks and being told no - by the World's Toughest Row Atlantic Dash Securing the finances and managing the stress of getting to the start line Her biggest fear and worrying about staying well enough to do the row Getting out on to the ocean. Having electrical issues with the boat Name of the boat - The Spirit of Bluestone Magical moments on the Atlantic Ocean Day 46 coming to the end of the row Rowing schedule and needing to get extra sleep during the night The challenges of team dynamics Finding their roles within the group Being the social secretary and bringing fun to the boat The biggest lesson from rowing the ocean You can do so much more than you think you can Being supported by the right people around you Dealing with the adventure blues How life in weird after rowing an ocean Being in a really exciting place Future challenges?! Words of advice from the CF perspective Learning to life with CF How to connect with Sophie You are capable of so much more than you think you are Learn to reframe the negative voices in your head Social Media Instagram @sophiefpierce @cruisingfree2025
Final hour Missouri Lieutenant Governor David Wasinger joins to talk about the special session that Gov. Kehoe has called and more. Marc is joined by Host of Show Me St. Louis Mary Caltrider and Producer Mary Thaier to preview the 30th anniversary of Show Me St. Louis. Ryan Wiggins, Host of Wiggins America talks Marty Makary statement on new Covid booster plus Jack Buck story.
In 1964, the future for children born with Cystic Fibrosis was grim - most faced a life cut tragically short. Today, the majority of people living with CF in the UK are adults, a testament to extraordinary medical progress.We meet Annabelle who lives with Cystic Fibrosis, and once believed she might not see her 18th birthday. And we hear from Dr Imogen Felton, a respiratory consultant at Royal Brompton Hospital, with expertise in cystic fibrosis, who tells us about the therapies crucial to this extended prognosis. The EDITH trial (Early Detection using Information Technology in Health) is testing how AI can help radiologists identify breast cancer at an earlier stage, transforming the future of diagnosis. We speak to Professor Sian Taylor-Philips, Professor of Population Health at the University of Warwick and co-leader of the trial.In 2024, participation in Run Clubs across the UK surged by 64%. But does running in a group lead to better performance? To find out, James laces up for a jog around Hyde Park with the Monday Mood Booster Run Club and speaks with Arran Davis, a postdoctoral researcher at the University of Oxford, who's exploring the links between social interaction and physical activity.Presenter: James Gallagher Producers: Debbie Kilbride, Minnie Harrop & Tom Bonnett Editor: Ilan Goodman Production coordinator: Ishmael Soriano This episode was produced in partnership with The Open University.
What if a scan could do more than show you a picture, what if it could tell you a story about what's happening inside a child's body, in real time?That's exactly what Dr. Chris Flask is working to make possible.Dr. Flask is a Professor of Radiology, Biomedical Engineering, and Pediatrics at Case Western Reserve University and University Hospitals of Cleveland. He's at the forefront of an exciting transformation in medical imaging, one that could change the way we care for children with rare genetic diseases like cystic fibrosis (CF) and polycystic kidney disease (PKD).“Our goal is to turn imaging, instead of just image creation, into data,” says Dr. Flask. “We want to create numbers. So we can say, this is what's going on in the lungs. And when we put these patients on modulator therapies, we can see a 10 percent improvement in their lung disease. And similar responses in the pancreas, the liver, and the gut. That's our goal—quantifying it through this fingerprinting methodology.”This approach, MRI fingerprinting, is a revolutionary leap forward. Developed over the past decade at Case Western's MRI center, it's fast, accurate, and most importantly for kids: it requires no sedation, no radiation, and no contrast agents. Each image slice takes just 15 seconds, making it safer and more accessible for the most vulnerable patients.Dr. Flask's work is supported by the NIH, the Cystic Fibrosis Foundation, and an extraordinary 42-year collaboration with Siemens MRI. Together, they're paving the way for multi-center clinical trials using this technology to better understand disease progression and therapy outcomes.This episode is all about the intersection of science, innovation, and compassion, and the powerful impact of data-driven care.We're honored to welcome Dr. Flask to the show, although he prefers we call him Chris. You won't want to miss this deep dive into what's next for pediatric imaging and precision medicine.Share with anyone who's passionate about medical innovation, pediatric health, or rare disease research. Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Send us a textJohnny and BW are back for a new season of Mississippi State Football.They discuss what they have been doing this summer, why they are doing the show and make their picks and predictions for the 2025 Bulldog Football Season.To support our cause to raise funds and awareness for Cystic Fibrosis go to Johnnypacker.net and order a fresh roasted bag of coffee from High Point Roasters in New Albany MS. Support the show
Pediatric Insights: Advances and Innovations with Children’s Health
This episode focuses on obstructive sleep apnea in children with cystic fibrosis and the critical need for proactive screening.
Dr. John Granton, a critical care and transplant physician at Toronto General Hospital, shares his journey in pulmonary hypertension and lung transplantation, detailing the groundbreaking advancements in transplant technology. He discusses the evolution of lung preservation methods, the challenges of chronic rejection, and the hope for longer-lasting transplants. With a passion for improving patient outcomes, Dr. Granton envisions a future where transplant becomes obsolete—replaced by treatments that cure underlying diseases. Learn more about pulmonary hypertension trials at www.phaware.global/clinicaltrials. Engage for a cure: www.phaware.global/donate #phaware Share your story: info@phaware.com Like, Subscribe and Follow us: www.phawarepodcast.com. @UHN @teamphhope #phawareMD #PHILD #transplant @phacanada
Guest: Dustin and Tequila Menken, Progyny Members at TE Connectivity Host: Dan Bulger, Progyny “I grew up with an expiration date.” Dustin Menken was born with cystic fibrosis, a genetic condition that brought him lifelong health challenges and made him part of the 98% of men with CF who are infertile. He never imagined he'd live to see 40, let alone become a father. But with persistence, support from his wife Tequila and a critical fertility benefit from his employer, TE Connectivity, through Progyny, Dustin beat the odds. Again. In this episode, Dustin and Tequila Menken share their remarkable story: from a childhood spent in hospitals to navigating genetic testing, sperm aspiration, and multiple IVF cycles. They walk us through the setbacks, the emotional toll, and the moment they finally learned they were expecting their daughter, Jannie Bell Allena, who has now arrived healthy and thriving. Tune into this episode for the Menkens story of resilience, partnership, and the power of access. Behind every fertility journey is a deeply personal fight - one that can be helped with the right support. For more information, visit Progyny's Podcast page and Progyny's Education page for more resources. Be sure to follow us on Instagram, @ThisisInfertilityPodcast and use the #ThisisInfertility. Have a question, comment, or want to share your story? Email us at thisisinfertility@progyny.com.
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