Podcasts about Definition

Angioedema – Recognition and Management in the ED Hosts: Maria Mulligan-Buckmiller, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Angioedema.mp3 Download Leave a Comment Tags: Airway Show Notes Definition & Pathophysiology Angioedema = localized swelling of mucous membranes and subcutaneous tissues due to increased vascular permeability. Triggers increased vascular permeability → fluid shifts into tissues. Etiologies Histamine-mediated (anaphylaxis) Associated with urticaria/hives, pruritus, and redness. Triggered by allergens (foods, insect stings, medications). Rapid onset (minutes to hours). Bradykinin-mediated Hereditary angioedema (HAE): C1 esterase inhibitor deficiency (autosomal dominant). Acquired angioedema: Associated with B-cell lymphoma, autoimmune disease, MGUS. Medication-induced: Most commonly ACE inhibitors; rarely ARBs. Typically lacks urticaria and itching. Gradual onset, can last days if untreated. Idiopathic angioedema Unknown cause; diagnosis of exclusion. Clinical Presentations Swelling Asymmetric, non-pitting, usually non-painful. May involve lips, tongue, face, extremities, GI tract. Respiratory compromise Upper airway swelling → stridor, dyspnea, sensation of throat closure. Airway obstruction is the most feared complication. Abdominal manifestations

Where can you actually use AlloClae? Dr. Franco breaks down how this first-of-its-kind filler for the body is changing what's possible. From subtle refinements to shape and volume exactly where you want it, AlloClae is donor fat processed for safety, ready off the shelf, and made specifically for larger body areas that traditional fillers can't handle. Patients love that it skips major surgery, keeps downtime low, and still delivers natural-looking results that blend perfectly with your anatomy. Popular areas to enhance: Hip dips, butt contour, calves Lipo irregularities, dents, or trauma spots Breast rippling, asymmetry, small touch-ups Muscle definition for pecs, shoulders, abs and more Arms, thighs, hands — anywhere you want a smooth shape AlloClae gives you more control, better shape, and results that look like you — just more sculpted. If you've ever wished you could fix tiny details without another round of surgery, or shape areas you can't hit with the gym alone, this opens a whole new world. Watch the full deep dive on YouTube or tune in wherever you get your favorite podcasts.  

The guys talk about NFL trade rumors, Jonathan Kuminga trade offers, and NBA offseason moves.

If you're a creative person, going abroad, exploring the world, living in new surroundings, seeing new things can add a new dimension to your work. It can inspire you to see your practice in a new light. The influences you gather over time, especially through travel, can only enrich what you create. On this episode of The Unfinished Print, a mokuhanga podcast, I speak with printmaker Kay Watanabe. Kay has spent many years splitting her time between Australia and Japan, and in doing so, she's developed her mokuhanga and other print work across two distinct cultural landscapes. We discuss what it means to create in those two different spaces under different circumstances and how Kay navigates this duality, we also discuss her love of washi, the way she develops her prints, and how mokuhanga fits into her broader artistic process. Please follow The Unfinished Print and my own mokuhanga work on Instagram @andrezadoroznyprints or email me theunfinishedprint@gmail.com Notes: may contain a hyperlink. Simply click on the highlighted word or phrase. Artists works follow after the note if available. Pieces are mokuhanga unless otherwise noted. Dimensions are given if known. Print publishers are given if known. Kay Watanabe - website Instagram Gallery Camellia - is an art gallery in the historic Okuno Building in Ginza, Tokyo, Japan.  Munakata Shikō (志功棟方) - (1903-1975) arguably one of the most famous modern printmakers; Shikō is renowned for his prints of women, animals, the supernatural and Buddhist deities. He made his prints with an esoteric fervour where his philosophies about mokuhanga were just as interesting as his print work.  Helen Frankenthaler (1928–2011) was a prominent American abstract expressionist painter known for her role in the Color Field painting movement. Her innovative technique involved staining unprimed canvas with thinned oil paint, creating a distinctive luminous effect. "Mountains and Sea" (1952) is a notable example of her influential work. Frankenthaler's contributions have left a lasting impact on postwar American art. Frankenthaler began to make woodcut prints in 1973 and was influenced by Utagawa Hiroshige (1797–1858).  More info about her prints can be found at  the Frankenthaler Foundation, here. Yoshida Hiroshi (1876-1950) - a watercolorist, oil painter, and woodblock printmaker. Is associated with the resurgence of the woodblock print in Japan, and in the West. It was his early relationship with Watanabe Shōzaburō, having his first seven prints printed by the Shōzaburō atelier. This experience made Hiroshi believe that he could hire his own carvers and printers and produce woodblock prints, which he did in 1925.  Gary Shinfield - is a draighstman, painter and printmaker based in Australia.  Seraphina Martin - is a printmaker based in Australia. More info can be found here, at Sydney Printmakers.  Terry McKenna  is a mokuhanga printmaker and teacher residing in Karuizawa, Japan. He received guidance in the art form from Richard Steiner, a prominent mokuhanga printmaker based in Kyoto. Terry established the Karuizawa Mokuhanga School, a renowned residency dedicated to mokuhanga education, located in Karuizawa, Japan.  Further details about Terry and his school can be found, here. Additionally, you can listen to Terry's interview with The Unfinished Print: A Mokuhanga Podcast, here and Richard Steiner's interview here.  mokulito - a type of lithography which incorporated woodblock. Artist Danielle Creenaune uses mokulito in her work. She has a fine detailed explanation on its uses, here.   International Mokuhanga Conference - is a bi-yearly conference dedicated to mokuhanga which started in 2011 by the International Mokuhanga Association. Each conference is themed. The latest conference was in 2021, delayed a year because of the pandemic. More information can be found, here. monotype print - is a unique print created from an image painted or drawn on a smooth surface, such as glass or metal, and then transferred to paper. Unlike most printmaking methods, where multiple copies of the same image can be produced, a monotype typically has a single, one-of-a-kind image. It's called a "mono" type because it is not part of an edition like traditional prints (e.g., lithographs, etchings), where you can make multiple copies.  © Popular Wheat Productions logo designed and produced by Douglas Batchelor and André Zadorozny  Disclaimer: Please do not reproduce or use anything from this podcast without shooting me an email and getting my express written or verbal consent. I'm friendly :)  Слава Українi If you find any issue with something in the show notes please let me know. ***The opinions expressed by guests in The Unfinished Print podcast are not necessarily those of André Zadorozny and of Popular Wheat Productions.***    

Wed, 30 Jul 2025 03:45:00 +0000 https://jungeanleger.podigee.io/2451-borsepeople-im-podcast-s20-04-kay-bommer 959ad82187df666fd54f3325985622e1 Kay Bommer ist Geschäftsführer des Deutschen Investor Relations Verbands DIRK. Der Jurist ist 2001 zum 1994 gegründeten DIRK gestossen, wir reden zu Beginn über Kays Zeit vor dem DIRK incl. Australien und dann über DIRKs Zeit vor Kay incl. Kreis. Die folgende 24-Jahre-Reise in die Ist-Zeit geht schnell, weil ich sehr viele Fragen zu ebendieser habe. Wie läuft der Austausch von Emittenten, Kapitalgebern sowie den relevanten Intermediären mit dem DIRK? Wie gross ist der Verband? Was sind die Megatrends 2025? Wie läuft die Zusammenarbeit mit der österreichischen CIRA? Wie ist die junge ESG-IR-Generation integriert? Und wie kann man die junge ETF-Privatanleger:innen-Generation verstärkt auch wieder für Einzelaktien gewinnen? Was muss man mitbringen, um IR-Manager:in zu werden? Bottom Line ist es ein Deep Dive in Selbstverständnis, Definition und Leitbild der Investor Relations in Deutschland geworden. http://www.dirk.org http://www.cira.at About: Die Serie Börsepeople des Podcasters Christian Drastil, der im Q4/24 in Frankfurt als "Finfluencer & Finanznetworker #1 Austria" ausgezeichnet wurde, findet im Rahmen von http://www.audio-cd.at und dem Podcast "Audio-CD.at Indie Podcasts" statt. Es handelt sich dabei um typische Personality- und Werdegang-Gespräche. Die Season 20 umfasst unter dem Motto „25 Börsepeople“ 25 Talks. Presenter der Season 20 ist Steiermärkische Sparkasse Private Banking https://www.sparkasse.at/steiermaerkische/privatkunden zum 200. Geburtstag des Instituts. Welcher der meistgehörte Börsepeople Podcast ist, sieht man unter http://www.audio-cd.at/people. Der Zwischenstand des laufenden Rankings ist tagesaktuell um 12 Uhr aktualisiert. Bewertungen bei Apple (oder auch Spotify) machen mir Freude: http://www.audio-cd.at/spotify , http://www.audio-cd.at/apple . 2451 full no Christian Drastil Comm. 2322

The peak body for organic producers is raising concerns about proposed changes to the definition of genetic modification. Food Standards for Australia and New Zealand is proposing food which has been 'gene edited' NOT be labelled as genetically modified. Australian Organic says the move would strip consumers of the right to know what they are buying, and could also pose a trade barrier. Rural Editor Emily Minney spoke with Chief Executive Jackie Bryan about the concerns.See omnystudio.com/listener for privacy information.

Is Zone 2 cardio really the key to longevity and fat loss—or have we been misled? In this solo episode, Louisa challenges the fitness status quo and reveals why low-intensity steady-state cardio might be wasting your time—especially if you're a woman. Drawing on new 2025 research and her deep background in exercise physiology, Louisa explains how men and women respond differently to training, and why higher-intensity workouts may be far more effective for improving mitochondrial health, brain aging, VO2 max, and metabolic flexibility. If you're a woman in your 30s, 40s, 50s, or 60s trying to optimize your longevity, brain function, and body composition—this is a must-listen.  True optimization and longevity never come from comfort alone. You'll learn: Why Zone 2 may not improve mitochondrial health like you think The real training zones that boost VO2 max, fat oxidation & brain function How perimenopausal and menopausal women must train differently The exact weekly routine to optimize longevity, body comp & cognition *** Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Troscriptions: Head to www.troscription.com/neuro | Code: NEURO for 10% your first order Boncharge: Head to www.boncharge.com | Code: NEURO15 for 15% off Ketone IQ: Head to www.ketone.com/NEURO for 30% OFF your subscription order + receive a free gift with your second shipment. Manukora: Head to www.manukora.com/neuro to save up to 31% plus $25 worth of free gifts with the Starter Kit. *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Topics discussed: 00:00:00: Exercising in zone 2 is a waste of time 00:00:43: Research that shifted her views, especially for women 00:01:41: What Is Zone 2? – Definition and physiology explained 00:02:17: Zone 2 in Practice – How it's measured in real-world settings  00:03:23: Comfort Zone Training – Why Zone 2 is easy but not effective  00:04:16: Elite Athletes vs. The Rest of Us 00:05:10: Why intensity matters more 00:08:11: Time efficiency and real-life experience 00:09:23: Brain Health & Mitochondria – Higher intensity for cognition  00:10:15: Why Zone 2 doesn't have special signaling power  00:12:25: Why higher zones burn fat better  00:13:35: Zones 1 through 5 explained 00:14:00: Zone 5: The Death Zone 00:15:18: Menopause & Muscle Fibers  00:16:55: Lactate Fuels the Brain 00:18:11: How to Train for Longevity – Resistance, intensity, and logic 00:23:59: VO2 Max   00:26:40: Norwegian 4x4 and weekly training strategy  00:30:00: Resistance Training 101 – 5x5 sets, compound lifts, and strength focus  00:31:38: Zone 2 as Recovery – When and how to actually use it 00:33:07: Final Takeaway – Zone 2 isn't bad, but it shouldn't be your priority 

On episode 1171 of Daytime Confidential, Luke Kerr, Jillian Bowe, Joshua Baldwin and Melodie Aikels dish the latest Beyond the Gates, The Bold and the Beautiful, Days of Our Lives, General Hospital and The Young and the Restless headlines and storylines, including:  Nicole faces off with Bill on Beyond the Gates after she learns the full truth from Martin. Kat and Tomas hit the sheets.  The Bold and the Beautiful goes to Italy. Can Nick get Brooke back? Why is B&B making a point to celebrate 8 toe Sheila?  Days of Our Lives is renewed for two more seasons. Johnny's trial begins and his grandma Susan returns to Salem. Could Marlena be EJ's shooter?  Willow is the definition of a Karen on General Hospital. Curtis spills Nina and Drew's secret to Willow. Lucas rushes to save Marco from Sonny's wrath. Is Drew GH's version of Grant Harrison from Another World?  Is it time for a new headwriter at The Young and the Restless? In the wake of Y&R killing off Chance, whose legacy dates back to the show's early days. There was no reason to kill off Chance. All this and more on the latest Daytime Confidential podcast! Bluesky: @DCConfidential, LukeKerr, JillianBowe, Josh Baldwin, and Melodie Aikels. Facebook: Daytime Confidential Subscribe to Daytime Confidential on iTunes, Google Play, and Spotify.  

This episode is brought to you by CLEARSTEM! If you're looking for skincare that's both anti-acne and anti-aging, CLEARSTEM has you covered. Their science-backed formulas help you achieve clear, glowing skin without pore-clogging ingredients. And we have a special deal for you—get 15% off your order when you visit https://www.clearstem.com/valeria and use the code VALERIA at checkout! In this week's episode of Not Alone, Valeria sits down with wellness expert, author, and content creator Aggie Lal for a refreshingly honest conversation about the current state of modern health culture for women, and what it really means to feel well in today's world. Aggie shares her personal journey from rigid routines, veganism, and biohacking for good labs to finding balance by reconnecting with her intuition, hormones, and overall purpose. Together, she and Valeria dive deep into the pressure to be “healthy” at the expense of joy, the shame around beauty choices like Botox, and why women are often left out of mainstream health narratives. Plus, a powerful discussion on how to separate your roles from your identity - so you can thrive, not just survive. Whether you're burnt out by wellness trends or looking to redefine your relationship with health and womanhood, this episode is a must-listen. Follow Aggie on Instagram: https://www.instagram.com/aggie Follow me: https://www.instagram.com/valerialipovetsky/  Shop my looks from this episode: intro/ads: https://shopmy.us/collections/1952399  aggie: https://shopmy.us/collections/1983674  What we talked about:  0:55 - Valeria's Family trip to Spain 3:29 - Introducing Aggie Lal 5:40 - Aggie's First Impressions of Valeria 7:13 - The World of Biohacking 9:35 - Being Vegan 10:30 - Body Trends 11:59 - Clearstem Ad 13:50 - Pillars of Biohacking  15:25 - What is Different for Females 18:00 - Aggie's Favorite Health Rituals 19:08 - Hypnotheray  23:45 - 4 Pillars of Health 24:10 - The Importance of Purpose 27:20 - Valeria's POV on Motherhood 29:55 - The Role of Mothers 31:57 - Best Methods of Recovery 38:04 - Ways to Connect with your Partner 40:32 - Pushing the Definition of Wellness 42:33 - Health Habits that Don't Work 45:52 - Aggie's Pregnancy 49:15 - Everything Women Must Juggle 51:30 - The Importance of Rest 53:50 - The Beauty of Feeling Free 56:25 - What's Next for Aggie Learn more about your ad choices. Visit megaphone.fm/adchoices

Elizabeth Weil, founder and managing partner of Scribble Ventures, just closed an $80 million Fund III focused on AI-native startups.She spent seven years at Twitter during hypergrowth from 60 to 2,500 employees, then built the Market Development team at Andreessen Horowitz.⭐ Sponsored by Podcast10x - Podcasting agency for VCs - https://podcast10x.comKey Topics discussed:The Scribble Network- 100+ operators and executives providing deal flow and portfolio support- Strategic angels helping companies scale- "Unfair advantages" through warm connectionsAI Investment Philosophy- Backing "AI-native" founders who "grew up" with the technology- Focus on proprietary data and unique workflows- Moat matters more than ever in a noisy landscapeBold Predictions- Every person will have a personalized tutor in their pocket- Digital immortality: preserving knowledge beyond physical existence- AI transforming healthcare, education, and daily behaviorsFounder Evaluation- Key question: "Why are you the team on this planet that is going to be able to build this company?"- Looking for "guttural desire" vs. whiteboard solutions- Warm introductions as primary signalFund Details- $80M Fund III for pre-seed and seed- $750K - $1.5M initial checks- Can lead, co-lead, or follow rounds- Intentionally generalist despite AI focusContact:- Website: scribble.vc- Email: hello@scribble.vc- X: @elizabethTimestamps:(00:00) Introduction(02:39) Elizabeth's journey from Stanford to Twitter(03:08) Early career and how she got into tech and startups(08:57) The Scribble Network and how it helps portfolio companies(12:21) Definition of AI-native companies and key characteristics of founding teams(14:17) Assessing the defensibility of a startup's data strategy(15:39) Learnings from operating at Twitter and Andreessen Horowitz(18:08) Key factors for investing at pre-seed and seed stages(20:13) Fundraising experience for Fund Three and navigating the LP landscape(23:03) Approach to valuations in the AI startup ecosystem(24:28) Exciting AI sub-sectors and areas with potential(30:15) Evaluating startups in a rapidly evolving AI landscape(31:51) Advice for early-stage founders on building their venture(34:08) Rapid fire round of questions about Scribble Ventures' investment strategyFor sponsorship or guest appearance requests, write to prashantchoubey3@gmail.comSubscribe to VC10X on Youtube, Spotify, Apple Podcasts.

Dive into the intricate world of the Uniform Commercial Code (UCC) with our latest episode. Designed for law students and professionals alike, this episode unpacks the UCC's foundational principles, focusing on its role in simplifying and modernizing commercial transactions. Explore key articles, from sales and secured transactions to negotiable instruments, and understand how the UCC fosters uniformity and flexibility in the ever-evolving landscape of commerce. Whether you're preparing for exams or seeking practical insights, this episode is your essential guide to mastering the UCC.Purpose of the UCC: The UCC aims to simplify, clarify, and modernize the law governing commercial transactions. It also seeks to permit the continued expansion of commercial practices through custom, usage, and agreement, and to make the law uniform among various jurisdictions.Variation by Agreement: The effect of UCC provisions can be varied by agreement, unless otherwise specified. However, the obligations of good faith, diligence, reasonableness, and care cannot be disclaimed by agreement, though parties may determine the standards for performance if those standards are not manifestly unreasonable.Definition of "Agreement" vs. "Contract": "Agreement" refers to the actual bargain of the parties as found in their language or implied from circumstances like course of dealing or usage of trade. "Contract" is the total legal obligation that results from the parties' agreement as affected by the UCC and other applicable rules of law.Good Faith Obligation: Every contract or duty within Subtitle I imposes an obligation of good faith in its performance or enforcement. This means parties must act with honesty in fact and, in the case of a merchant, observe reasonable commercial standards of fair dealing.Formation of a Sales Contract: A contract for the sale of goods can be made in any manner sufficient to show agreement, including conduct by both parties. Even if one or more terms are left open, a contract does not fail for indefiniteness if the parties intended to make one and there is a reasonably certain basis for an appropriate remedy.Statute of Frauds for Sales: A contract for the sale of personal property is generally not enforceable beyond $5,000 in amount or value unless there is a writing indicating a contract for sale, stating a price, reasonably identifying the subject matter, and signed by the party against whom enforcement is sought. This specific rule does not apply to contracts for the sale of goods covered by Article 2.Merchantability Warranty: If the seller is a merchant with respect to goods of the kind, an implied warranty of merchantability is given, meaning the goods must be fit for the ordinary purposes for which such goods are used, among other requirements. This includes the serving of food or drink for value.Holder in Due Course Requirements: To be a holder in due course, a person must take the instrument for value, in good faith, and without notice that it is overdue, has been dishonored, or has any defense against or claim to it on the part of any person. These elements ensure the holder is a legitimate and unsuspecting party.Security Interest Definition: A "security interest" is defined as an interest in personal property or fixtures that secures payment or performance of an obligation. A seller's retention or reservation of title to goods after shipment or delivery to the buyer is limited in effect to a reservation of a security interest.Scope of Article 9 (Secured Transactions): Article 9 applies to any transaction intended to create a security interest in personal property or fixtures (including goods, documents, instruments, accounts, contract rights, chattel paper, general intangibles) and to any sale of accounts, contract rights, or chattel paper. It broadly covers various forms of security agreements.

Episode 99.  What is your definition of success? What happens when we fail? What is the impact of AI on our work, goals and ability to fail or succeed.In this episode of the Lifetime at Work podcast, host Greg Martin interviews Minyang Jiang (MJ), Chief Strategy Officer at the FinTech company Credibly. MJ shares insights from her career journey, which includes a strong educational background at Harvard and Wharton and professional experiences at Ford Motor Company. The conversation delves into the evolving role of AI in FinTech, how AI is expected to transform education and the workplace, and the personal impact of career failures. Min Yang Jang emphasizes the importance of fostering curiosity, adapting to technological changes, and finding new ways to derive meaning and success through collaborative efforts and continuous learning.00:00 Introduction to the Podcast and Guest01:08 MJ's Background and Career Journey02:38 The Value of Education in Career Development04:38 The Future of Education and AI's Role07:22 Lessons from Failure and Personal Growth15:56 Transition to Credibly and Role Overview17:03 AI's Impact on FinTech and Business Strategy26:30 Embracing AI with a Sense of Wonder28:13 The Impact of AI on Careers and Workplaces28:56 Raising the Bar: The Future of Expertise31:12 The Quest for Meaning in the Age of AI38:00 The Role of Teams and Collaboration41:35 Comparing Innovation Models: China vs. the US47:03 Final Thoughts and Advice for the Future

In Episode 259 our guest host, Danielle, answers our questions about her tastes, preferences, and feelings about the board gaming hobby as a casual board gamer. Timestamps:00:00 Introduction01:05 Definition of a Casual Board Gamer05:30 Thinking About Board Games10:21 Buying/Looking For New Games17:10 Learning New Games32:45 Board Game Complexity33:09 Board Game Conventions36:00 Board Game Annoyances47:03 Listener ShoutoutIf you enjoy the show, please consider supporting us at https://www.patreon.com/boardgamehottakesFollow us on BlueSky: https://bsky.app/profile/boardgamehottakes.bsky.socialJoin our Board Game Arena Community: https://boardgamearena.com/group?id=11417205Join our Discord server at: ⁠⁠⁠⁠⁠⁠⁠⁠https://discord.gg/vMtAYQWURd

Tuesday Headlines: Trump will ‘bring an end to the misery' in Gaza, New child safety bill could see providers feel force of law within weeks, Equality body to argue over whether sex is ‘binary biological reality’, Webjet has been hit with a $9 million fine from the ACCC, and Bend It Like Beckham is set for a re-boot. Deep Dive: Would you pay for a second chance at life after death? Many Aussies are, having already signed up, and now paying to be the next to undergo cryogenic freezing when they die. Two people have undergone the procedure at a cryonics facility in Australia so far, and while it's drawn its critics, enthusiasts say most of history’s greatest achievements first endured similar sentiment. In this episode of The Briefing, Tara Cassidy speaks with South Australian resident Alex, a Southern Cryonics member, who’s signed up to see what the future holds. Follow The Briefing: TikTok: @thebriefingpodInstagram: @thebriefingpodcast YouTube: @LiSTNRnewsroom Facebook: @LiSTNR NewsroomSee omnystudio.com/listener for privacy information.

In this JCO Article Insights episode, Michael Hughes summarizes “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma" by Avet-Loiseau et al. published on June 09, 2025 along with an interview with author Dr Nikhil C. Munshi, MD. TRANSCRIPT Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I am interviewing Dr. Nikhil Munshi on the “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma” by Avet-Loiseau et al. At the time of this recording, our guest has disclosures that will be linked in the transcript. While some patients with multiple myeloma live for decades after treatment, others exhibit refractory or rapidly relapsing disease irrespective of treatment administered. We term this “high-risk myeloma.” Multiple risk stratification systems have been created, starting with the Durie-Salmon system in 1975 and evolving with the advent of novel therapeutics and novel treatment approaches. In 2015, the Revised International Staging System (R-ISS) was introduced, which incorporated novel clinical and cytogenetic markers and remained, until recently, a mainstay of risk stratification in newly diagnosed disease. Myeloma as a field has, just in the past few years, though, undergone explosive changes. In particular, we have seen groundbreaking advances not only in treatments - the introduction of anti-CD38 agents and the advent of cellular and bispecific therapies - but also in diagnostic technology and our understanding of the genetic lesions in myeloma. This has led to the proliferation of numerous trials employing different definitions of high-risk myeloma, a burgeoning problem for patients and providers alike, and has prompted attempts to consolidate definitions and terminology. Regarding cytogenetic lesions, at least, Kaiser et al's federated meta-analysis of 24 therapeutic trials, published here in the JCO in February of 2025 and recently podcasted in an interview with associate editor Dr. Suzanne Lentzsch, posited a new cytogenetic classification system to realize a shared platform upon which we might contextualize those trial results. This article we have here by Dr. Avet-Loiseau, Dr. Munshi, and colleagues, published online in early June of this year and hot off the presses, is the definitive joint statement from the International Myeloma Society (IMS) and the International Myeloma Working Group (IMWG). What is high-risk multiple myeloma for the modern era? The IMS and IMWG Genomics Workshop was held in July 2023 and was attended by international myeloma experts, collaborating to reach consensus based on large volumes of data presented and shared. The datasets included cohorts from the Intergroupe Francophone du Myélome (IFM); the HARMONY project, comprised of multiple European academic trials; the FORTE study, findings from which solidified KRd as a viable induction regimen; the Grupo Español de Mieloma Múltiple (GEM) and the PETHEMA Foundation; the German-Speaking Myeloma Multicenter Group (GMMG); the UK-based Myeloma XI, findings from which confirmed the concept of lenalidomide maintenance; Emory 1000, a large, real-world dataset from Emory University in Atlanta; the Multiple Myeloma Research Foundation Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass) dataset; and some newly diagnosed myeloma cohorts from the Mayo Clinic. Data were not pooled for analyses and were assessed individually - that is to say, with clear a priori understanding of whence the data had been gathered and for what original purposes. Consensus on topics was developed based on the preponderance of data across studies and cohorts. In terms of results, substantial revisions were made to the genomic staging of high-risk multiple myeloma, and these can be sorted into three major categories: A) alterations to the tumor suppressor gene TP53; B) translocations involving chromosome 14: t(14;16) (c-MAF overexpression), t(14;20) (MAFB overexpression), and t(4;14) (NSD2 overexpression); and C) chromosome 1 abnormalities: deletions of 1p or additional copies of 1q. In terms of category A, TP53 alterations: Deletion of 17p is present in up to 10% of patients at diagnosis and is enriched in relapsed or refractory disease. This is well-documented as a high-risk feature, but the proportion of the myeloma cells with deletion 17p actually impacts prognosis. GEM and HARMONY data analyses confirmed the use of 20% clonal cell fraction as the optimal threshold value for high-risk disease. That is to say, there must be the deletion of 17p in at least 20% of the myeloma cells on a FISH-analysis of a CD138-enriched bone marrow sample to qualify as high-risk disease. TP53 mutations can also occur. Inactivating mutations appear to have deleterious effects similar to chromosomal losses, and the biallelic loss of TP53, however it occurs, portends particularly poor prognosis. This effect is seen across Myeloma XI, CoMMpass, and IFM cohorts. Biallelic loss is rare, it appears to occur in only about 5% of patients, but next-generation sequencing is nevertheless recommended in all myeloma patients. Category B, chromosome 14 translocations: Translocation t(14;16) occurs in about 2% to 3% of patients with newly diagnosed disease. In the available data, primarily real-world IFM data, t(14;16) almost always occurs with chromosome 1 abnormalities. Translocation t(4;14) occurs in about 10% to 12% of newly diagnosed disease, but only patients with specific NSD2 alterations are, in fact, at risk of worse prognosis, which clinically appears to be about one in every three of those patients. And so together, the CoMMpass and Myeloma XI data suggest that translocation t(4;14) only in combination with deletion 1p or gain or amplification of 1q correlates with worse prognosis. Translocation t(14;20) occurs in only 2% of newly diagnosed disease. Similar to translocation t(4;14), it doesn't appear to have an effect on prognosis, except if the translocation co-occurs with chromosome 1 lesions, in which case patients do fare worse. Overall, these three translocations - t(14;16), t(4;14), and t(14;20) - should be considered high-risk only if chromosome 1 aberrations are also present. In terms of those chromosome 1 aberrations, category C, first deletions of 1p: Occurring in about 13% to 15% of newly diagnosed disease, deletion 1p eliminates critical cell checkpoints and normal apoptotic signaling. In the IFM and CoMMpass dataset analyses, biallelic deletion of 1p and monoallelic deletion of 1p co-occurring with additional copies of 1q denote high-risk. In terms of the other aberration in chromosome 1 possible in myeloma, gain or amplification of 1q: This occurs in up to 35% to 37% of newly diagnosed disease. It upregulates CKS1B, which is a cyclin-dependent kinase, and ANP32E, a histone acetyltransferase inhibitor. GEM and IFM data suggest that gain or amplification of 1q - there was no clear survival detriment to amplification - is best considered as a high-risk feature only in combination with the other risk factors as above. Now, in terms of any other criteria for high-risk disease, there remains one other item, and that has to do with tumor burden. There has been a consensus shift, really, in both the IMS and IMWG to attempt to develop a definition of high-risk disease which is based on biologic features rather than empirically observed and potentially temporally dynamic features, such as lactate dehydrogenase. Beta-2 microglobulin remains an independent high-risk indicator, but care must be taken when measuring it, as renal dysfunction can artificially inflate peripheral titers. The consensus conclusion was that a beta-2 microglobulin of at least 5.5 without renal failure should be considered high-risk but should not preclude detailed genomic profiling. So, in conclusion, the novel 2025 IMS-IMWG risk stratification system for myeloma is binary. It's either high-risk disease or standard-risk disease. It's got four criteria. Number one, deletion 17p and/or a TP53 mutation. Clonal cell fraction cut-off, remember, is 20%. Or number two, an IGH translocation - t(4;14), t(14;16), t(14;20) - with 1q gain and/or deletion of 1p. Or a monoallelic deletion of 1p with 1q additional copies or a biallelic deletion of 1p. Or a beta-2 microglobulin of at least 5.5 only when the creatinine is normal. This is a field-defining work that draws on analyses from across the world to put forward a dominant definition of high-risk disease and introduces a new era of biologically informed risk assessment in myeloma. Now, how does this change our clinical approach? FISH must be performed on CD138-enriched samples and should be performed for all patients. Next-generation sequencing should also be performed on all patients. Trials will hopefully now begin to include this novel definition of high-risk multiple myeloma. It does remain to be seen how data from novel therapeutic trials, if stratified according to this novel definition, will be interpreted. Will we find that therapies being evaluated at present have differential effects on myelomas with different genetic lesions? Other unanswered questions also exist. How do we go about integrating this into academic and then community clinical practice? How do we devise public health interventions for low-resource settings? To discuss this piece further, we welcome the esteemed Dr. Nikhil Munshi to the podcast. Dr. Munshi is a world-renowned leader in multiple myeloma and the corresponding author on this paper. As Professor of Medicine at Harvard Medical School, Director of the Multiple Myeloma Effector Cell Therapy Unit, and Director of Basic and Correlative Science at the Jerome Lipper Multiple Myeloma Center of the Dana-Farber Cancer Institute, he has presided over critical discoveries in the field.  Thank you for joining us, Dr. Munshi. Dr. Nikhil Munshi: Oh, it's my pleasure being here, Michael, to discuss this interesting and important publication. Michael Hughes: I had a few questions for you. So number one, this is a comprehensive, shall we say, monumental and wide-ranging definition for high-risk myeloma. How do you hope this will influence or impact the ways we discuss myeloma with patients in the exam room? And how do we make some of these components recommended, in particular next-generation sequencing, feasible in lower-resource settings? Dr. Nikhil Munshi: So those are two very important questions. Let's start with the first: How do we utilize this in our day-to-day patient care setting? So, as you know well, we have always tried to identify those patients who do not do so well with the current existing treatment. And for the last 30 years, what constitutes a myeloma of higher risk has continued to change with improvement in our treatment. The current definition basically centers around a quarter of the patients whose PFS is less than 2 to 3 years. And those would require some more involved therapeutic management. So that was a starting point of defining patients and the features. As we developed this consensus amongst ourselves - and it's titled as “International Myeloma Society, International Myeloma Working Group Consensus Recommendation” - this IMS-IMWG type of recommendation we have done for many years, improvising in various areas of myeloma care. Now, here, we looked at the data that was existing all across the globe, utilizing newer treatment and trying to identify that with these four-drug regimens, with transplant and some of the immunotherapy, which group of patients do not do as well. And this is where this current algorithm comes up. So before I answer your question straight, “How do we use it?” I might like to just suggest, “What are those features that we have identified?” There are four features which constitute high-risk disease in the newer definition. Those with deletion 17p with 20% clonality and/or TP53 mutation. Number two, patients with one of the translocations - t(4;14), t(14;16), or t(14;20) - co-occurring with 1q amplification or deletion 1p32. And that's a change. Previously, just the translocation was considered high-risk. Now we need a co-occurrence for it to be called high-risk. The third group is patients having biallelic deletion 1p32 or monoallelic deletion 1p32 along with 1q amplification. And finally, patients with high beta-2 microglobulin, more than or equal to 5.5 mg/dL, with normal creatinine less than 1.2 mg/dL. And the question, “How do we use this?” There are multiple areas where we incorporate high-risk features in our treatment algorithm. One of the first areas is where we would consider the induction regimen. If a patient has a high-risk disease, we would definitely consider a four-drug regimen rather than a three-drug regimen, although we are beginning to incorporate four-drug for all groups. That's one important thing. Number two, those are the patients where we do consider consolidation with transplant or maybe in the new world, considering some of the immunotherapeutic consolidation more early or more aggressively. Number three, these are the patients who get a little bit more maintenance therapy. So normally, lenalidomide might end up being our standard maintenance regimen. In patients who have high-risk disease, we incorporate either addition of daratumumab or the anti-CD38 targeting antibody and/or addition of proteasome inhibitor, either bortezomib or carfilzomib. So you would have multi-drug maintenance therapy in these patients. And in high-risk patients, we follow them with maintenance longer periods of time. One very critically important point to keep in mind is that to get the better outcome in high-risk disease, we must try to get them into MRD negativity because there is clear data that patients who do achieve MRD negativity, despite having high-risk disease, have a much superior outcome. They become near to standard-risk disease. And so, in high-risk patients, I would try to do whatever various options I have to try and get them into MRD-negative status. And when these patients relapse, we do not wait for the classic progression criteria to be met before we intervene. We would propose and suggest that we intervene earlier before the disease really blasts off. And so there are a number of areas in our setting where this high-risk definition will help us intervene appropriately and also with appropriate aggressiveness to achieve better outcome, to make this similar to standard-risk disease. Michael Hughes: Thank you, Dr. Munshi. And thoughts on how to really integrate this not only into academic centers but also lower-resource settings? Dr. Nikhil Munshi: So that's a very important question, Michael. And when we were developing this consensus, we were very cognizant of that fact. So wherever available, I think we are recommending that over a period of next 2, 3, 5 years, we should begin to switch over to sequencing-based methods because two components of this definition, one is TP53 mutation, which we cannot do without sequencing, and also reliably detecting deletion 1p requires sequencing-based method. So in the low-resource countries - and there are many in this world, and also even in our own country, patients may not be able to afford it - the older method with FISH or similar such technology, which is more affordable, is also acceptable for current time. They may miss a very small number of patients, maybe 2% to 3%, where these finer changes are not picked up, but a majority of this would be captured by them. So the current practice might still be applicable with some limitation in those patient populations, and that's what we would recommend. What is happening, fortunately, is that actually sequencing-based method is becoming cheaper. And in many centers, it is cheaper to do the sequencing rather than to do the FISH analysis. And so my hope is that even in low-resource centers, sequencing might be more economical in the end. It's, I think, the access to technology, which is a little bit limited currently, but it's hopefully becoming available soon. Michael Hughes: Thank you, Dr. Munshi. And staying for a minute and looking at the multiple myeloma subsets which might be missed by this really still very broad-ranging high-risk definition, at least by prior risk stratification systems, right, there is this group of patients who have standard-risk cytogenetics by R-ISS or R2-ISS, but they have primary refractory disease or they relapse early. We call these, as you are well aware, functionally high-risk disease. What proportion of previously FHR, functionally high-risk, myeloma patients do you expect to be captured by this novel definition? Dr. Nikhil Munshi: So I think the newer definition - and we can look at it both ways, but the newer definition should capture most of the functionally high-risk definition. To put it differently, Michael, there are patients who we know are, as you mentioned, functionally high-risk. Those are the patients who might have plasma cell leukemia, those who might have extramedullary disease, those who might not respond to our four-drug induction. If you don't respond to the four-drug induction, almost by definition, they are high-risk. However, a majority of them have one of the abnormalities that we are describing here. There would be a very small proportion which may not have. And if they do not have, we know one of the important components of this definition here is also that the genome, we know, keeps on evolving. So there may be a very small clone with the high-risk feature which was not obvious in the beginning. Following treatments or following relapse, that clone predominates, and now the patient's disease becomes high-risk.  So the definition would incorporate or would capture these functional high-risk patients, but as you said, in countries where resources are not available, using this functional high-risk would also be helpful and advantageous. Sometimes LDH ends up being a high-risk. In our studies, LDH has not come out to be high-risk anymore because the features we are describing captures most of those patients, but those alternatives, older, can still be considered if other newer techniques are not available. Michael Hughes: Got you. And in terms of these older definitions, yes, that incorporate tumor burden, these empirical observations about how myeloma presents, do you foresee any additional tumor burden indicators being added to future definitions of high-risk disease? Or do you instead see this particular definition as a major waypoint on the journey towards a fully biologically grounded definition of high-risk disease? Dr. Nikhil Munshi: I think your second part is what is going to happen. I think the tumor burden-related definition is being now replaced by the biological or genomic-based definition. And I think at some point, it will be quite fully replaced. One component not here, and it is because one thing, we don't have enough data; number two, we don't know how it will pan out, is also the influence of the microenvironment on the risk definition. For example, the immune system, the immune function, etc. But not enough data exists to suggest how it would change the current definition. So in future, would a definition be totally genomic or it could be more integrative? And my personal guess is that it would be more integrative and that some immune features might come into the picture, especially now that we are using immune-based therapy as a very important component of treatment - CAR T-cells, bispecific, and antibody-based treatments. What role the immune system plays in either supporting tumor or what role suppression of the anti-tumor immunity plays? They all will be important how patient outcomes end up being, and which in turn could translate into how patient's risk stratification might happen. So I think the older tumor burden-related definitions probably will become things of the past. What we have currently proposed and consensus developed is the new path forward, and over time, some microenvironmental influences, if defined and found to be important, may get some more incorporation if it compares favorably with the genomic features. Michael Hughes: Thank you, Dr. Munshi for that enlightening response.  To conclude the podcast, I'd like to look to the future and to the immediate future, what are the next steps for high-risk disease definition between now and discussing an integrated genomic-microenvironment-based definition? Will we see attempts to refine? Will we see a multi-level system, things like this? Dr. Nikhil Munshi: Yeah, so I think the current definition will be here to stay for the next 10 years or so. I think this has been developed using a large amount of data, so we do believe that this will remain fine. It has been validated now within the last six months by a few of the other studies. So there won't be a quick change. But we will try to, all of us will try to innovate. And as you very rightly bring up, the areas of research would include looking at the expression or transcriptomic component. Does that matter? And we do believe a small number of patients will have transcriptomic changes, not looked at the DNA changes, and may play a role. There are newer components, so long non-coding RNA, for example, is going to be an important component to look at, how it impacts the disease outcome, etc. There are also some of the proteomic-related changes which may become important in our studies. And then as we discussed, microenvironment and immunological changes. So these are the future areas of ongoing research where we all should collect data, and then in the next 5 to 10 years, we'll have another group meeting to see has anything changed or any of the features have become more important.  Most of the time, some of the older features are lost because they are not as critically high-risk, and the newer features come in. And so the historical background for just one second, there was a time when chromosome 13 was considered a high-risk disease. We now don't even mention it because it's not high-risk. The newer treatments have improved the outcome. t(4;14) used to be a high-risk disease. Now by itself today, in this definition by itself is not; it needs to be with something else. And so I think this is a great sign of progress. As we improve the treatment and outcomes, some of the features will become less important, new features will come up, and we'll need to keep on evolving with time and with technology and make it better for patients. Michael Hughes: Thank you so much, Dr. Munshi, for your wisdom, for your sagacity, for your historical perspective as well.  Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries. And be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

The Stages of Labour explained clearly, including the 3 main stages (and an extra 4th!), as well as covering factors affecting delivery (commonly called the 3 P's) and also includes the Cardinal Movements of Labour - the movements the fetus undertakes during delivery! Consider subscribing on YouTube (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 Definition of Labor1:09 Stage 1 of Labor2:49 Stage 2 of Labor3:27 Stage 3 of Labor4:35 The Unofficial Stage 4 of Labor5:03 The 3 P's6:39 Cardinal Movements of LaborPDFs Available Here:www.rhesusmedicine.comPlease remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice. #medicalmnemonic #medicalmnemonics #rhesusmedicine #studymedicine #studygram #medstudent #medicalschool

On this episode, Mark Thornton gives a crash course on the sleight-of-hand world of inflation, how it really works, why the official story doesn't add up, and who benefits from the illusion. Drawing on Austrian insights, Mark dissects the politically engineered cycle of government overspending, Treasury bond issuance, and Federal Reserve money creation. You'll learn how inflation doesn't just “happen”: it's a deliberate policy that distorts markets, transfers wealth, and props up an elite few while undermining the productive economy. The Fed's role isn't heroic. It's central to the problem.Additional Resources"What Is Inflation? Clarifying and Justifying Rothbard's Definition" by Kristoffer Hansen and Jonathan Newman (Quarterly Journal of Austrian Economics): https://mises.org/MI_130_A"Too Much Money Portends High Inflation" by John Greenwood and Steve Hanke (Wall Street Journal): https://mises.org/MI_130_BRegister for the 2025 Mises Institute Supporters Summit in Delray Beach, Florida, October 16–18: https://mises.org/ss25Be sure to follow Minor Issues at https://Mises.org/MinorIssues

The 8am hour of Friday's Mac & Cube continued with us defining what would be a successful season for most of the SEC teams, like Alabama, Auburn, Georgia, Florida, LSU, Arkansas, Oklahoma, Ole Miss, Missouri, and Mississippi State "McElroy & Cubelic In The Morning" airs 7am-10am weekdays on WJOX-94.5!!See omnystudio.com/listener for privacy information.

Friday's 9am hour of Mac & Cube started off with the rest of our discussion on what would make a successful season for the rest of the SEC, like Texas, Tennessee, South Carolina, Vanderbilt, Texas A&M, and Ole Miss; later, Greg reveals a few systems (i.e. nerd numbers) that should help you predict NFL success; and finally, we get excited to watch Happy Gilmore 2 this weekend. "McElroy & Cubelic In The Morning" airs 7am-10am weekdays on WJOX-94.5!!See omnystudio.com/listener for privacy information.

In this episode of the Rocket Chiro Podcast, Jerry tackles a topic that comes up often in chiropractic circles: the fear of “losing the profession.” Where does this fear come from, and is it justified? Jerry explores five key fears that often drive this concern: Losing Chiropractic Identity The never-ending debate between subluxation-based vs evidence-based chiropractors continues to divide the profession. Jerry shares why this internal conflict may be doing more harm than good, and why the “real chiropractor” argument is a dead-end. Becoming Like Osteopaths What happens if chiropractic loses its distinctiveness? Jerry explains why drifting toward drugs and surgery undermines the very foundation of chiropractic care. Losing Autonomy Like PTs Could chiropractors become mere technicians under the thumb of medical gatekeepers? Jerry unpacks the risks of giving up professional independence for the sake of integration. Over-Restricting Scope of Practice From subluxation-only to short-term pain relief only, both ends of the spectrum are pushing for a narrower version of chiropractic. Jerry offers a balanced take on where scope discussions go off the rails, and where raising the bar might actually help. Insurance Regulation and Reimbursement This is the fear that hits closest to home. Jerry breaks down how forced insurance participation and restricted reimbursement could severely limit chiropractic care, and what chiropractors need to watch out for moving forward. Final Thoughts: The biggest threat to the profession may not be any of these five fears, but rather the lack of agreement about what chiropractic actually is. Without a shared understanding, it's hard to communicate chiropractic's value to the public, policy makers, or even each other. Jerry's Definition (for now): "Chiropractic is a drug-free, non-surgical form of care focused on evaluating and improving the function of the spine and joints. Chiropractic care is designed to restore motion, reduce discomfort, and enhance the body's natural ability to function and heal." If you're a chiropractor looking for help with your website, local SEO, or practice growth, visit RocketChiro.com to learn more. You can also request a free website and SEO review or explore the Next Step program for new and stuck chiropractors. Thanks for listening. Be sure to subscribe, share this episode with a fellow chiropractor, and leave a review if you found it valuable.     Want Help Growing Your Practice? Jerry offers business coaching, website design, SEO, and Google Ads services specifically for chiropractors. If you're ready for less stress and more momentum, visit RocketChiro.com. Free Website/SEO Review: https://rocketchiro.com/chiropractic-practice-assessment Best chiropractic websites: https://rocketchiro.com/best-chiropractic-websites Chiropractic SEO: https://rocketchiro.com/chiropractic-seo Coaching for Chiropractors: https://rocketchiro.com/join

Kettenraucher – Eine Kette zu rauchen, macht keinen Sinn. Mit einem Kettenraucher kann man aber über den Sinn seines Handelns nicht diskutieren.

RIFC can't get the job done on big CBS with the first round of El Clamico ending in a nil nil draw. But it wasn't what happened in the match as much as what happened after the game that has been making most of the news this week.

Darrell Castle talks about what the Director of National Intelligence, Tulsi Gabbard, called a treasonous conspiracy by officials at the highest levels of the Obama White House to subvert the will of the American people. Transcription / Notes THE VERY DEFINITION OF A COUP Hello, this is Darrell Castle with today's Castle Report. This is Friday the 25th day of July in the year of our Lord 2025. I will be talking about what the Director of National Intelligence, Tulsi Gabbard, called a treasonous conspiracy by officials at the highest levels of the Obama White House to subvert the will of the American people.  Before I begin I want to take a moment and recognize that this month is the 15th anniversary of the Castle Report. Yes, folks I have been doing this for 15 years. It was conceived in a hotel in the state of Idaho back in 2010 after a discussion with some friends in the Constitution Party about how we needed people to speak on the issues. I said I will do it but only if no one tries to control what I say or what I talk about and to this point no one has. I will admit that sometimes I wonder if anyone cares about the issues enough to control what I say. Yes, Tulsi made some explosive accusations and she has released the documents to prove them. I'm starting to think that perhaps it was not a good idea for Hillary Clinton to refer to Tulsi as a Russian agent during the 2016 primary campaign. Perhaps it was not even a good idea to have her placed on the terrorist watch list so she would be unnecessarily searched in every airport she traveled through. Maybe you should not have had Tulsi followed by dog teams and maybe you should not have taken her electronic gadgets including her U.S. Army issued laptop and phone as she traveled through airports. Yes, what goes around comes around and now the way Tulsi has been treated by Democrats, especially since she used to be one, is and has been shameful but am I saying she released the documents for revenge. No, I'm not saying that because the documents speak for themselves and Tulsi has demonstrated the honor expected of a 20-year army officer to this point. Revenge can be sweet though, and as they say it is a dish best served cold. How explosive are Tulsi's allegations let's take a look. By the way I assume that everyone is aware of what I'm talking about in regard to the completely false Russia gate accusations against Trump so my intent is to look at the possible ramifications. The word treason is often used because it is a capital offense with no statute of limitations and so the charges can be brought no matter how long ago the alleged offense occurred. Think about it like this folks; the senior official in charge of all American Intelligence operations is now stating unequivocally that former President Obama and the subordinates of his team intentionally sabotaged the peaceful transfer of power in 2016.  She tells us, in effect, that they violated their oaths, betrayed their sworn duty to the American people, and attempted a coup against the legitimate government of the United States. In other words, they set out to weaken and then overthrow the government of the United States. They did all this, allegedly, not on behalf of some foreign power, but on behalf of their own power. They had power and they wanted to keep it because I suppose they had the power addiction really bad and they just couldn't be bothered about the rules of the game. So, do those charges constitute treason. The United States Constitution Article 3 Section 3 defines treason. “Treason against the United States, shall consist only in levying war against them, or in adhering to their enemies, giving them aid and comfort. No person shall be convicted of treason unless on the testimony of two witnesses to the same overt act, or on confession in open court.” So, again do the allegations constitute treason. I suppose one could try to allege that the acts constituted war against the...

Ever wondered what truly qualifies something as "art"? Join us as we dive into fascinating philosophical debates, from chimpanzee painters and curious pieces of driftwood to a giant ketchup bottle that sparked a museum controversy.  We'll explore why defining art has baffled thinkers for centuries, discuss who gets to decide, and reveal how these questions shape our understanding of creativity itself.

This episode begins a two episode arc discussing how changing conditions can change motivation with Wouter Stellaard, Behavior 360 and the Kuzo Group. In this episode Wouter discusses the many, and not exclusive, ways in which we can change conditions to change motivation that do not involve diet management.  The episode begins by discussing motivation as a construct and a label and then breaking down motivating operations and setting events. Wouter educates on the many ways in which we can alter antecedents and the environment in order to effect motivation.  Additionally, Wouter encourages listeners to evaluate ourselves and our shaping plans.  Stay tuned in for Wouter's “Training Tale” about getting into the weeds of training Calm Attentive Behaviors (CAB) with wolves at Bearizona.   For questions or suggestions about the podcast email ⁠abc@theabma.org⁠ and to contact Wouter email wstellaard@behavior360.com or wouters@thekuzogroup.com For more information and to register for the ABMA virtual courses visit this link: ⁠⁠https://www.theabma.org/behavior-management-courses⁠⁠To complete the podcast feedback survey visit this link: ⁠⁠https://lp.constantcontactpages.com/sv/Rspt0Bk/abcpodcast2025⁠⁠Let's talk some training and banter about behavior! 3:50 Introduction to Wouter Stellaard 9:40 A jumping off point for a discussion 11:35 Change from weight management mindset to behavior management mindset15:10 Definition of Motivation18:50 Motivation as a label 22:55 Motivation and the Study of One in One Moment26:20 Definition of Motivating Operations and Setting Events 29:20 Relationship and Trust 30:40 Variety of reinforcers 31:10 Variety of asked behaviors, rate of reinforcement 33:20 Shifting the mindset to what we can do and away from the animal isn't motivated37:10 Antecedents and changing the environment 43:50 Evaluating ourselves 49:55 Differential Outcome Effect52:00 Competing Reinforcers 56:30 Reevaluating our shaping plan59:40 Low Motivation vs Reinforced Behavior 1:03:50 Social Structure and Hierarchy 1:13:50 “Training Tales” 

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Kyle B. Enfield, MD, FCCM, speaks with Brian T. Wessman, MD, FACEP, FCCM, and Fajun Wang, MD, about maximizing professional growth through active engagement with SCCM. Drawing on their personal experiences, the guests reflect on how early involvement through residency, fellowship, and the Fundamental Critical Care Support (FCCS) course ignited long-term involvement in the Society. Drs. Wessman and Wang outline actionable strategies for new and seasoned members alike. They emphasize the value of committee and section participation, trainee liaison roles, and the mentorship programs, particularly the initiative tailored for international medical graduates. The conversation sheds light on the application process and professional significance of becoming a Fellow of the American College of Critical Care Medicine (FCCM). Whether you're navigating your first SCCM Congress or considering applying for FCCM designation, this episode is a comprehensive guide to supersizing your SCCM membership—turning involvement into influence and professional growth into sustained impact. Resources referenced in this episode: SCCM's LearnICU platform  Choosing Wisely for Critical Care: The Next Five (Zimmerman JJ, et al. Crit Care Med. 2021;49:472-481) The Definition of the Intensivist in the Era of Global Healthcare (Wu D, et al. Crit Care Med. 2025;53:e548-e554).

Buchtipp:Luis Paulitsch: Alternative Medien. Definition, Geschichte und Bedeutung. Springer Natur 2025.Zum Verlaghttps://link.springer.com/book/10.1007/978-3-658-47633-5Zum Fall Frauke Brosius-Gersdorfhttps://www.tagesschau.de/inland/innenpolitik/brosius-gersdorf-verfassungsgericht-100.htmlhttps://www.ndr.de/kultur/kritik-an-brosius-gersdorf-lancierte-kampagne-rechtspopulistischer-medien,schimmele-100.html // Die Dunkelkammer ist ein Stück Pressefreiheit. Unabhängigen Journalismus kannst Du mit einer Mitgliedschaft via Steadyunterstützen https://steady.page/de/die-dunkelkammer/aboutVielen Dank! Michael Nikbakhsh im Namen des Dunkelkammer-Teams

In the final hour, Leila Rahimi and Marshall Harris discussed a variety of topics in the 5 On It segment. Later, they listened to Cubs manager Craig Counsell explain why star right fielder Kyle Tucker is out of the starting lineup Wednesday afternoon in the team's series finale against the Royals.

Please help keep this podcast free: https://www.patreon.com/grumpyseoguy1:23 How to plan a SEO Zoom Advisory Call with me2:48 Definition of dr3:17 DR doesn't mean what people think3;55 Low DR backlinks can be good, too4:19 Here's the episode about Marketing SEO Spam4:35 anchortext definition5:44 The problems with high DR websites7:12 Don't buy backlinks based on DR7:29 The episode about lower DR ranking over higher DR8:12 A refersher of a good backlinks:8:16 contextual8:20 likely on a relevant website8:22 on a relevant post8:25 makes sense grammatically and syntactically8:31 doesn't look like it was written for SEO8:36 Episodes 37 and 39 describe more about the difference between a good and bad backlink9:14 Here's the scam10:05 Anything that can be automated will not help SEO11:07 If you're buying backlinks based on DR you are probably going to get scammed11:53 Content wrtiers dislike this podcast12:07 Developers dislike this podcast12:21 The 4 things that are necessary to rank13:13 Dwell time is not a ranking factor13:14 content quality is not a ranking factor13:15 UX is not a ranking factor13:32 How Impressions work13:52 How to know how much traffic you are going to get16:01 Quality of content is not a ranking factor16:04 Dwell time is not a ranking factor16:06 AI is not stealing your traffic16:09 LLMS.txt does nothing16:12 EEAT is not a ranking factor16:19 Even Google admits EEAT is not a ranking factor16:26 Anyone offering you an EEAT audit is scamming you16:30 Anyone offering you an HCU audit is scamming you16:32 Anyone claiming they can get you in the AI tools is probably scamming you or trying to sell you some trash that won't help you16:39 Anyone claiming UX is a ranking factor is scamming you16:54 Don't buy backlinks based on DR17:00 a LEGIT DR80 backlink on a homepage would easily be $10,000 per month.18:12 There are better ways to spend your money18:23 Most DR80 websites are owned by companies and corporations that do not sell backlinks18:29 DON'T BUY BACKLINKS BASED ON DR

As the end of the year creeps closer, nonprofit teams often find themselves overwhelmed, scrambling to meet bold goals with dwindling energy. In this candid episode, I walk you through a powerful mid-year capacity check process that helps you avoid Q4 burnout—and hit your year-end targets with clarity and intention.I dive into why year-end chaos really begins in the summer and how capacity blindness can sabotage even the best-laid plans. I also share a step-by-step process you can use right now to recalibrate your goals, protect your team's bandwidth, and stay aligned with your mission.In this episode, you'll learn:Why “capacity blindness” derails execution—even when your goals are realisticHow to run a simple yet powerful capacity check with your teamWhat mid-year planning can reveal that annual planning often missesKey takeaways:Capacity blindness is not about setting bad goals—it's about underestimating the labor, time, and money needed to meet them.Cognitive simplification protects us in the short term but leads to chaos later without a structured override.A mid-year capacity check brings visibility to hidden resource gaps and lets you recalibrate before burnout sets in.The Mid-Year Capacity Check: Step-by-StepBreak Down Goals into Tasks List every activity required to achieve each goal—no matter how small. Think copywriting, email design, board prep, stewardship steps, etc.Estimate Time, Money, Ownership For each task, estimate how many hours it will take, who will do it, and what it will cost.Assess Current Capacity Ask: Does the person responsible actually have the bandwidth? Is the funding secure? How maxed out are people already?Expand the Definition of Capacity Can you use templates, bring in board members, or lean on partners to lighten the load?Make Strategic Adjustments If capacity doesn't match your goals, now's the time to pivot—not in October when it's too late.Resources Mentioned:

In this unfiltered conversation, I sit down with renowned sex and relationship coach Caitlin V. to explore the truths about male performance anxiety, orgasms, slowing down intimacy, and why men might be misunderstanding their own desires — and women's. We discuss how societal pressures create performance myths, the importance of pacing and communication in the bedroom, why curiosity beats confidence, and the misconceptions around anal play, identity, and masculinity. Plus, Caitlin shares her wildest orgasm story and the fantasy she hasn't tried… yet.

Leisa grew up without a lot of money, so naturally she assumed that if she had money, she wouldn't have problems! While this isn't true, of course, she went down the path to understanding money and teaching others how to come into confidence around money. Her book is a parable about money catalysts because catalysts speed things up. Lauren dives into the 8 money catalysts: Awaken to Possibility, Begin Within, Unearth the Abundant World, Nurture Your Inner Wealth, Define Your Own Abundance, Amplify Your Finances, Navigate Decisions, and Take Inspired Action. They close by discussing what it means to go forward and embrace life's shadows, which you should do too!If you liked this episode, you'll also like episode 204: Definition of Courage: Act in Spite of Fear.About Leisa:Leisa Peterson is a transformational money mindset coach, bestselling author, and financial educator who helps people revolutionize their relationship with money. Drawing from over 30 years in financial services, she founded WealthClinic to guide individuals past financial anxiety toward holistic wealth-building.Author of "The Money Catalyst" and "The Mindful Millionaire," Leisa combines practical financial strategies with mindfulness practices to create lasting transformation. Recognized by Forbes as one of the pioneering "10 Women Driving Growth in Wealth Management and Investing," she hosts The Mindful Millionaire podcast and YouTube channel. Her expertise has been featured in The Wall Street Journal, FastCompany, The Week, Huffington Post, and Gaia Media Network.Winner of SRQ Magazine's 2023 "Women Who Roar" Illuminator award, Leisa empowers clients through online workshops and transformative retreats, particularly supporting those at pivotal crossroads where money intersects with personal vision.Leisa lives in Sedona, Arizona, with her husband Tim and enjoys visits from their two successfully launched children.Connect with Leisa:Lpeterson@wealthclinic.comWebsite: https://wealthclinic.com/The Money Catalyst Book: https://moneycatalystbook.com/ FREE GIFTS including 47 page journal and 10+ guided meditations for book purchase by filling out simple opt-in.Free Resources:https://wealthclinic.com/visionSocial Media:Instagram: https://www.instagram.com/leisapeterson/LinkedIn: https://www.linkedin.com/in/leisapeterson/Facebook: https://www.facebook.com/leisapetersoncoach/YouTube: https://www.youtube.com/c/LeisaPetersonWealthClinicConnect with Lauren:https://www.realadultingiseasy.com/⁠⁠⁠https://twitter.com/AdultingIsEasy https://www.instagram.com/adultingiseasyreal/About Lauren:Lauren Keen Aumond is passionate about personal finance. She hosts the Adulting Is Easy podcast, where she helps make adulting easier for listeners by making money easier. Lauren became a millionaire at age 31 through high income, investing in stocks, and owning and managing real estate. She was able to leave her 9-5 at age 33 and now manages her short- and long-term rentals on the west coast of Florida with her husband. For fun, Lauren plays tennis, spends time with her family, drinks red wine, travels, and boats.

In today's media landscape, journalists are drowning in pitches while PR professionals scramble for attention—often missing the mark entirely. But what if the problem isn't the story, but the way it's being told—and the tools we're using to tell it? In this episode, we sit down with Brett Farmiloe, the revivalist behind Help a Reporter Out (HARO), to unpack why this once-iconic platform fell off the radar, how he brought it back to life, and what it now takes to genuinely stand out in a journalist's inbox.Listen For5:56 Why Journalists Are Still Drowning in Spam7:05 The HARO Pitch Formula: Helpful, Authentic, Relevant, On-Time10:20 Is the Definition of “Journalist” Changing?14:05 What Journalists Really Want from PR People20:15 Answer to Last Episode's Question From Guest Graham Goodkind Guest: Brett FarmiloeWebsite | Email | X | LinkedIn | HARO LinkedInStories and Strategies WebsiteCurzon Public Relations WebsiteApply to be a guest on the podcastConnect with usLinkedIn | X | Instagram | You Tube | Facebook | Threads | Bluesky | PinterestRequest a transcript of this episodeSupport the show

Guest Suggestion Form: ⁠⁠⁠⁠⁠⁠⁠⁠https://forms.gle/bnaeY3FpoFU9ZjA47⁠⁠⁠⁠⁠⁠⁠⁠Disclaimer: This video is intended solely for educational purposes and opinions shared by the guest are his personal views. We do not intent to defame or harm any person/ brand/ product/ country/ profession mentioned in the video. Our goal is to provide information to help audience make informed choices. The media used in this video are solely for informational purposes and belongs to their respective owners.Order 'Build, Don't Talk' (in English) here: ⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.eu/d/eCfijRu⁠⁠⁠⁠⁠⁠⁠⁠Order 'Build Don't Talk' (in Hindi) here: ⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.eu/d/4wZISO0⁠⁠⁠⁠⁠⁠⁠⁠Follow Our Whatsapp Channel: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.whatsapp.com/channel/0029VaokF5x0bIdi3Qn9ef2J⁠⁠⁠⁠⁠⁠⁠⁠Subscribe To Our Other YouTube Channels:-⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@rajshamaniclips⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@RajShamani.Shorts⁠⁠⁠⁠⁠⁠⁠⁠

Is your engineering team running like the wild, wild west? What does engineering excellence look like in practice?In this episode, Ganesh Datta, co-founder and CTO of Cortex, explores what it takes to achieve engineering excellence. Ganesh shares lessons from his own journey, from early bug-fixing to building a company focused on engineering excellence.We discuss how platform engineering and internal developer platforms (IDPs) can help teams scale, improve reliability, and align with business outcomes. Ganesh also explains why culture, leadership, and clear metrics matter more than any single tool.If you're looking to make your engineering team a true business driver, this conversation is for you.Key topics discussed:How to define engineering excellence and why it's tied to business outcomes.The critical role of leadership in connecting engineering initiatives to business values.When to invest in platform engineering and internal developer platforms as your team grows.Common misconceptions about platform engineering.The importance of clear metrics, shared language, and transparency for continuous improvement.Building a culture that supports operational excellence through rituals and repeated messaging.Real-world examples of using generative AI to accelerate platform adoption and incident analysis.Timestamps:(00:00) Trailer & Intro(01:56) Career Turning Points(07:50) The Practice of Finding the Patterns in Issues(11:39) The Definition of Engineering Excellence(17:10) The Leader's Role in Engineering Excellence(22:31) Aligning Engineering Excellence with the Business Outcomes(26:30) The Importance of Metrics in Engineering Excellence(33:35) The Culture that Drives Engineering Excellence(39:05) Platform Engineering and Internal Developer Platform(45:02) The Biggest Misconception of Platform Engineering or IDP(50:36) Cortex as an Engineering Excellence Platform(52:39) Generative AI Use Case in Platform Engineering(55:26) 3 Tech Lead Wisdom_____Ganesh Datta's BioGanesh Datta is a Co-Founder & CTO of Cortex. Before co-founding Cortex, he was a Principal Software Engineer at Mission Lane where he was responsible for driving the development of real-time underwriting infrastructure. At LendUp, Ganesh was a Senior Software Engineer leading the development and optimization of the company's decisioning infrastructure and financial account management system. Ganesh holds a bachelor of science in computer science from the University of California San Diego.Follow Ganesh:LinkedIn – linkedin.com/in/gsdattaTwitter – x.com/gsdattaWebsite – www.cortex.ioEmail – ganesh@cortex.ioJoin Ganesh & Cortex at IDPCon in NYC – ipdcon.comLike this episode?Show notes & transcript: techleadjournal.dev/episodes/225.Follow @techleadjournal on LinkedIn, Twitter, and Instagram.Buy me a coffee or become a patron.

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This week we are covering what is 'traditional' Astrology.  The wonderful AstroWiki where you can read lots of articles about Astrology https://www.astro.com/astrowiki/en/Main_Page Magazines mentioned: Stellar https://www.astrologicalassociation.com/stellar/ The Mountain Astrologer https://mountainastrologer.com/ England's First Astrology Book by Chris Mitchell  https://amzn.to/4lEW5q5 Amazon link I may earn a small commission if you click the link

God's Definition of Church Pt 2 - Brandon Dukes by The Church of Christ Wheeler Area

07-18-25 - Our Sales Dept Has Put Up Posters Of Ted Lasso That Look Like Hitler - Emailer Asks If She's Got Definition Of Slumpbuster Right - Big News Trump Announces Coke Is Putting Sugar Back Into SodaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

07-18-25 - Our Sales Dept Has Put Up Posters Of Ted Lasso That Look Like Hitler - Emailer Asks If She's Got Definition Of Slumpbuster Right - Big News Trump Announces Coke Is Putting Sugar Back Into SodaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A Missoula judge has ordered the state to pay about $95,000 in attorneys' fees in a case over a state law defining male and female.

Nikolay and Michael are joined by Andrew Johnson and Nate Brennand from Metronome to discuss MultiXact member space exhaustion — what it is, how they managed to hit it, and some tips to prevent running into it at scale. Here are some links to things they mentioned:Nate Brennand https://postgres.fm/people/nate-brennandAndrew Johnson https://postgres.fm/people/andrew-johnsonMetronome https://metronome.comRoot Cause Analysis: PostgreSQL MultiXact member exhaustion incidents (blog post by Metronome) https://metronome.com/blog/root-cause-analysis-postgresql-multixact-member-exhaustion-incidents-may-2025Multixacts and Wraparound (docs) https://www.postgresql.org/docs/current/routine-vacuuming.html#VACUUM-FOR-MULTIXACT-WRAPAROUNDmultixact.c source code https://github.com/postgres/postgres/blob/master/src/backend/access/transam/multixact.cAdd pg_stat_multixact view for multixact membership usage monitoring (patch proposal by Andrew, needing review!) https://commitfest.postgresql.org/patch/5869/PostgreSQL subtransactions considered harmful (blog post by Nikolay) https://postgres.ai/blog/20210831-postgresql-subtransactions-considered-harmfulvacuum_multixact_failsafe_age doesn't account for MultiXact member exhaustion (thread started by Peter Geoghegan) https://www.postgresql.org/message-id/flat/CAH2-WzmLPWJk3gbAxy8dHY%2BA-Juz_6uGwfe6DkE8B5-dTDvLcw%40mail.gmail.comAmazon S3 Vectors https://aws.amazon.com/blogs/aws/introducing-amazon-s3-vectors-first-cloud-storage-with-native-vector-support-at-scale/MultiXacts in PostgreSQL: usage, side effects, and monitoring (blog post by Shawn McCoy and Divya Sharma from AWS) https://aws.amazon.com/blogs/database/multixacts-in-postgresql-usage-side-effects-and-monitoring/Postgres Aurora multixact monitoring queries https://gist.github.com/natebrennand/0924f723ff61fa897c4106379fc7f3dc And finally an apology and a correction, the membership space is ~4B, not ~2B as said by Michael in the episode! Definition here:https://github.com/postgres/postgres/blob/f6ffbeda00e08c4c8ac8cf72173f84157491bfde/src/include/access/multixact.h#L31And here's the formula discussed for calculating how the member space can grow quadratically by the number of overlapping transactions:Members can be calculated via: aₙ = 2 + [sum from k=3 to n+1 of k]This simplifies to: aₙ = (((n+1)(n+2))/2) - 1~~~What did you like or not like? What should we discuss next time? Let us know via a YouTube comment, on social media, or by commenting on our Google doc!~~~Postgres FM is produced by:Michael Christofides, founder of pgMustardNikolay Samokhvalov, founder of Postgres.aiWith special thanks to:Jessie Draws for the elephant artwork 

Thanks to The Podcast Academy, Ti King and I got to attend #PopCon with the intention of evangelizing podcasting (and the Academy, of course! See links for joining, below.) After I got used to the costumed attendees of PopCon, and fan-girled a few anime voice talents and celebrities on site, I got down to business and led a panel of podcasting experts on how to create, market, and monetize a podcast. Guests include Brittany Bigelow of Bigelow Creative, Dawn-Michelle Lewis of Salutations Media, filmmaker and podcast host Vergie Rodriguez, and James Starace of Focus 360/Creator Square.  We covered strategies for podcast concept development, the value of niche topics and micro-influencers, technical execution, and effective marketing strategies. The panel also explained their monetization techniques, from securing brand partnerships to leveraging subscriber models. The whole PopCon event was eye-opening, by the way, with more people lined up to meet the faces behind their favorite voices than the known faces playing TV characters! Ti, who graciously captured the video of the panel, Vergie and I also won Best Podcast awards from the organization! Ti King, E.B. Moss - Podcast Award Winners Next year, we're looking forward to a day dedicated to #podcasting, but for now, take advantage of the wisdom captured by this panel of pros on Making, Marketing, and Monetizing Podcasts! 01:12 Meet the Panelists 02:31 Debating the Definition of a Podcast 04:02 Starting Your Own Podcast 07:46 Technical Tips for Podcasting 12:49 Marketing Your Podcast 16:54 Monetizing Your Podcast 21:15 Navigating the Podcast Advertising Options 22:02 Challenges with Brand Associations and Advertisers 23:36 More Monetization Strategies for Podcasts 24:40 Understanding Podcast Ad Placements and Effectiveness 25:32 The Value of Micro Podcasts and Audience Engagement for Brands 29:19  Subscription Models and Additional Revenue Streams 30:43 Leveraging Press and Visibility for Podcast Growth 34:22 Branding and Consistency in Podcast Production 38:18 Practical Tips for Podcast Launch and Growth 40:42 Best Practices Wrap up Links/Connections: Follow, Connect & Share the Love The Podcast Academy Connect with E.B. Moss and Insider Interviews: With Media & Marketing Experts LinkedIn: https://www.linkedin.com/in/mossappeal Instagram: https://www.instagram.com/insiderinterviews Facebook: https://www.facebook.com/InsiderInterviewsPodcast/ Threads: https://www.threads.net/@insiderinterviews If you enjoyed this episode, follow Insider Interviews, share with another smart business leader, and leave a comment on @Apple or @Spotify… or a tip in my jar to help me tip my producer, Jim Mullen!: https://buymeacoffee.com/mossappeal!       

In CrossFit, we're trying to get people fit, but what does that actually mean? We're revisiting CrossFit's definition of fitness why you need to know it to better coach your athletes.Join Todd & Kristin every Thursday at 9am EST for LIVE Coach Development!--

Millennials and Gen Z love authenticity. But is authenticity all it's cracked up to be? Joseph Holmes and Nathan Clarkson investigate and give their takes.   References and resources: Definition: https://www.merriam-webster.com/dictionary/authentic   Definition and history: https://plato.stanford.edu/entries/authenticity/   Present debates about authenticity: https://www.psychologytoday.com/us/basics/authenticity   Is authenticity overrated? https://www.psychologytoday.com/us/blog/return-stillness/201909/is-authenticity-overrated https://www.forbes.com/sites/forbesbooksauthors/2022/11/22/authenticity-is-overrated-building-a-more-effective-leadership-style/   When do people feel most authentic? https://www.sciencedirect.com/science/article/abs/pii/S0092656618302964 Blesses We Are Not as Strong as We Think We Are (Song) Ragamuffin (Movie) The Life of Chuck (Movie) Curses Materialists (Movie) How to Be Single (Movie)

In this episode, Chris Kluis, VP of Product Operations & Data at Actabl, discusses his family's unique history with artificial intelligence, how early curiosity sparked his career journey, and why experimentation matters more than theory. Chris provides practical advice for hospitality professionals looking to start leveraging AI today, shares lessons from implementing AI at scale, and explores how digitization, effective prompting, and careful data management can unlock real business value.We cover:0:00 – Intro01:35 – How it started: Chris's family history with AI07:33 – What is AI? Definition and how it works09:54 – Use case: AI for advertising11:58 – Starting with personal AI use cases13:43 – Encouraging curiosity and learning14:57 – Personalized podcasts with NotebookLM16:21 – AI podcasts replacing humans?17:21 – Trust and AI19:08 – Importance of “Human in the loop”20:22 – HITEC 2025: AI in hotel tech today23:21 – Can AI expand opportunities?25:36 – Hoteliers: Start by digitizing workflows29:13 – “Treat AI like a new employee”33:17 – Higher-order thinking and AI35:51 – Building repeatable AI systems36:56 – ChatGPT vs Gemini vs other LLMs39:56 – What makes a good AI prompt?41:26 – Juxtaposition of new vs old44:21 – Skills to develop to stay relevant46:18 – Personal and professional next steps49:03 – Voice-powered AI50:50 – Corporate AI policies51:58 – Where Chris learns about AI54:26 – How AI will shape life and work A few more resources: If you're new to Hospitality Daily, start here. You can send me a message here with questions, comments, or guest suggestions If you want to get my summary and actionable insights from each episode delivered to your inbox each day, subscribe here for free. Follow Hospitality Daily and join the conversation on YouTube, LinkedIn, and Instagram. If you want to advertise on Hospitality Daily, here are the ways we can work together. If you found this episode interesting or helpful, send it to someone on your team so you can turn the ideas into action and benefit your business and the people you serve! Music for this show is produced by Clay Bassford of Bespoke Sound: Music Identity Design for Hospitality Brands

John Kiriakou exposes how the CIA faked torture results, waterboarded Abu Zubaydah 83 times, and covered it all up. He breaks down how Bush said “We do not torture” while CIA leadership destroyed tapes and rewrote FBI intel to justify illegal methods.

Today, we're unpacking the progressive shift at Baylor University, a prominent Baptist institution in Waco, Texas, and its recent acceptance of an almost $700,000 grant from the Eula Mae and John Baugh Foundation. We explore how this funding, aimed at fostering "LGBTQ inclusion" in churches, signals a broader leftward drift at Baylor, despite its historical ties to Baptist values. We'll dive into the grant's purpose and its implications for biblical fidelity, and the university's embrace of progressive ideologies like standpoint epistemology and DEI initiatives. We'll also examine Baylor's ties to the Baptist General Convention of Texas, its evolving policies on sexuality, and the broader cultural and spiritual battle over institutional capture. Share the Arrows 2025 is on October 11 in Dallas, Texas! Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠sharethearrows.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for tickets now! Sponsored by: ⁠Carly Jean Los Angeles⁠: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.carlyjeanlosangeles.com⁠⁠⁠⁠⁠⁠⁠⁠ Good Ranchers⁠: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.goodranchers.com⁠⁠⁠⁠⁠⁠⁠⁠ ⁠EveryLife⁠: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.everylife.com⁠⁠⁠⁠⁠⁠⁠⁠ Buy Allie's new book, "Toxic Empathy: How Progressives Exploit Christian Compassion": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/4COtBxy⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Timecodes: (00:50) Baylor's new initiative (17:55) About the Foundation (25:19) Baylor's ties to the Foundation (30:10) More about Baylor (38:47) Baylor's shift left (54:25) Definition of marriage --- Today's Sponsors: We Heart Nutrition — Get 20% off women's vitamins with We Heart Nutrition, and get your first bottle of their new supplement, Wholesome Balance; use code ALLIE at ⁠⁠⁠⁠⁠⁠⁠⁠https://www.WeHeartNutrition.com⁠⁠⁠⁠⁠⁠⁠⁠. Good Ranchers — Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GoodRanchers.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and subscribe to any of their boxes (but preferably the Allie Beth Stuckey Box) to get free Waygu burgers, hot dogs, bacon, or chicken wings in every box for life. Plus, you'll get $40 off when you use code ALLIE at checkout. A'del — Try A'del's hand-crafted, artisan, small-batch cosmetics and use promo code ALLIE 25% off your first time purchase at AdelNaturalCosmetics.com Seven Weeks Coffee — Experience the best coffee while supporting the pro-life movement with Seven Weeks Coffee; use code ALLIE at ⁠⁠⁠⁠⁠⁠⁠https://www.sevenweekscoffee.com⁠⁠⁠⁠⁠⁠⁠ to save up to 25% off your first order, plus your free gift! NetSuite — Gain visibility and control of your financials, planning, budgeting, and inventory so you can manage risk, get reliable forecasts, and improve margins. Go to NetSuite.com/ALLIE to get the CFO's guide to AI and Machine Learning. --- Episodes you might like: Ep 908 | Calling Out Cru's LGBTQ Compromise https://podcasts.apple.com/us/podcast/ep-908-calling-out-crus-lgbtq-compromise/id1359249098?i=1000634953278 Ep 960 | Unraveling Cru's Troubling LGBTQ Curriculum https://podcasts.apple.com/us/podcast/ep-960-unraveling-crus-troubling-lgbtq-curriculum/id1359249098?i=1000647583878 Ep 364 | Christians vs. Cancel Culture | Guest: Dr. Christina Crenshaw https://podcasts.apple.com/us/podcast/ep-364-christians-vs-cancel-culture-guest-dr-christina/id1359249098?i=1000507755971 --- Links: Baylor's press release: https://socialwork.web.baylor.edu/news/story/2025/courage-margins-c3i-awarded-research-grant Megan Basham's thread: https://x.com/megbasham/status/1940564251384357229 --- Buy Allie's book, You're Not Enough (& That's Okay): Escaping the Toxic Culture of Self-Love: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://alliebethstuckey.com/book⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Relatable merchandise – use promo code 'ALLIE10' for a discount: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://shop.blazemedia.com/collections/allie-stuckey Learn more about your ad choices. Visit megaphone.fm/adchoices

Simon Sinek is a speaker, founder, and an author. We live in an age of uncertainty, where finding purpose in your life feels harder than ever. So, how do you find a purpose that moves you and trust that it's worth pursuing? How can you be sure your purpose serves both yourself and the world? In a world starved for meaning, finding yours might be the most important thing you ever do. Expect to learn if we are in a crisis of purpose, how to deliberately cultivate meaning in your life, how to find your Why and and what makes for a good Why, which struggles Gen Z can learn from millennials mistakes, why men are specifically are struggling with directionlessness in the modern world, if loneliness the cost of leadership, how you can apply an infinite mindset to your personal life and not just business, and much more... Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get up to $350 off the Pod 5 at https://eightsleep.com/modernwisdom Get 5 Free Travel Packs, Free Liquid Vitamin D, and more from AG1 at https://ag1.info/modernwisdom Get the best bloodwork analysis in America at https://functionhealth.com/modernwisdom Get a Free Sample Pack of LMNT's most popular Flavours with your first purchase at https://drinklmnt.com/modernwisdom Timestamps: (00:00) Are We In A Crisis Of Purpose? (09:32) Why It's Important To Sit In 'The Mud' With Someone (22:24) Simon's Definition of Friendship (35:45) Everyone Thinks They Are On The Side Of Good (44:04) Reverse Frankl Law & How Maslow Got It Wrong (53:40) Success Is Learning Failure Can Be A Good Thing (1:04:19) How To Stop Feeling Guilty When You Take A Day Off (1:10:41) Don't Confuse Your Goals With Life Purpose (1:22:38) Reflecting On The “Millennial Question” 10 Years Later (1:36:03) Advice For Someone Paralyzed By Fear (1:41:21) What's Next For Simon Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

Final Supreme Court opinions for the term, Colorado redefines grandparent, and the history of Mt. Rushmore. Plus, small town scholarships, Cal Thomas reflects on being an American, and the Thursday morning newsSupport The World and Everything in It today at wng.org/donateAdditional support comes from Ambassadors Impact Network. Inviting entrepreneurs with a mission to connect with faith-based investors who share their vision. More at ambassadorsimpact.comFrom Dordt University, whose online MBA and MPA programs prepare leaders for lasting impact. Dordt University. Until All Is Made New. And from The Issues, et cetera podcast. Expert guests, Expansive topics, Extolling Christ. More at issuesetc.org