Podcasts about immunocompromised

Cyclospora is an uncommon but important cause of prolonged watery diarrhea in children, particularly during the summer months and during foodborne outbreaks. This episode reviews the epidemiology, clinical presentation, diagnostic pitfalls, treatment, and practical emergency department approach to recognizing and managing pediatric cyclosporiasis.   Learning Objectives Recognize the clinical features and epidemiology of Cyclospora cayetanensis infection in children, including when to suspect the diagnosis in patients with prolonged watery diarrhea. Select appropriate diagnostic testing for cyclosporiasis and identify the limitations of routine stool cultures, ova and parasite examinations, and gastrointestinal pathogen panels. Apply evidence-based treatment and supportive care for pediatric cyclospora infection, including appropriate antimicrobial therapy, hydration, and follow-up considerations. References Stobbe M. Outbreak of diarrhea-causing parasite grows to more than 1,000 cases. ABC News. Published July 8, 2026. Accessed July 10, 2026.   Bilung LM, Tahar AS, Yunos NE, et al. Detection of Cryptosporidium and Cyclospora oocysts from environmental water for drinking and recreational activities in Sarawak, Malaysia. Biomed Res Int. 2017;2017:4636420. doi:10.1155/2017/4636420.   Giangaspero A, Gasser RB. Human cyclosporiasis. Lancet Infect Dis. 2019;19(7):e226-e236. doi:10.1016/S1473-3099(18)30789-8.   Pyzocha N, Cuda A. Common intestinal parasites. Am Fam Physician. 2023;108(5):487-493.   Centers for Disease Control and Prevention. Clinical care of cyclosporiasis. Updated March 8, 2024. Accessed July 10, 2026.  Transcript This transcript was generated using Descript and subsequently reviewed and lightly edited for spelling, grammar, and clarity. Minor inaccuracies may remain, and the audio recording should be considered the definitive version of this content.   Welcome to PEM Currents: The Pediatric Emergency Medicine Podcast. As always, I'm your host, Brad Sobolewski. It's July and a seven-year-old comes into your emergency department with 10 days of watery diarrhea. They were seen earlier in the week and told it was probably viral gastroenteritis. Maybe they got a prescription for ondansetron, maybe they didn't. Stool cultures have already come back negative. Mom tells you, “Every time I think he's finally getting better, the explosive diarrhea comes right back.” So what's going on? Today we're talking about Cyclospora. Honestly, it's one of those organisms that most of us forget about until summer rolls around, or since medical school. We don't diagnose it every week, and depending on where you practice, you may go years without seeing a case. But then an outbreak happens, and maybe just a handful of sporadic cases show up, and suddenly you're reminded that not every child with prolonged diarrhea has viral gastroenteritis. Cyclospora cayetanensis is a coccidian protozoan that's transmitted through contaminated food or water. In the United States, it's most commonly associated with imported fresh produce, things like cilantro, basil, lettuce, salad mixes, and berries. Unlike bacterial food poisoning, everyone at the picnic usually isn't sick, so it often presents as an isolated illness because the exposure happened days earlier and may have involved only one particular food item. Families are often trying to remember the one thing that they ate that made everybody sick. Honestly, sometimes it's simply the salad they bought at the grocery store a week ago. One thing that's helped me remember these organisms over the years is that they each sort of develop their own personality. You know, it's often confused with Giardia and Cryptosporidium. So if the diarrhea is greasy, think Giardia. If it's profuse, watery diarrhea after swimming, think Cryptosporidium. If it's prolonged, watery diarrhea during the summer, think Cyclospora. Now, obviously there are exceptions, but I think that's a pretty useful framework, especially when you're seeing patients one after another in a busy ED. One of my favorite pearls about Cyclospora, and I think it's probably the one fact that's most worth remembering because it explains how it sort of works. Unlike Giardia or Cryptosporidium, the oocysts that are passed in stool aren't immediately infectious. They actually have to spend days to weeks out in the environment before they mature enough to infect somebody else. So Cyclospora isn't really spread by the kids sitting next to them at daycare. It's spread by the salad they both ate last week. I think that's a lot easier to remember than trying to memorize the organism's life cycle. The incubation period averages about seven to 10 days, so by the time symptoms begin, families usually don't remember exactly what their kid ate. They're certainly not connecting today's diarrhea with the salad they had a week ago. The diarrhea itself is usually watery, sometimes pretty high volume, sometimes even explosive. One thing that's a little deceptive is that it tends to wax and wane. Parents will tell you, “Yesterday I thought we had finally turned the corner,” and today they're right back where they started. Along with the diarrhea, you'll often see abdominal cramping, bloating, nausea, fatigue, maybe even a low-grade fever, and if this has been going on for a while, some weight loss or poor weight gain. Most of these kids don't walk in looking critically ill. They walk in because they're still having diarrhea when everyone expected them to be over it. That's really the patient where Cyclospora should come to mind. And of course, not every child with prolonged diarrhea has it. Giardia is still incredibly common, especially after untreated water exposure, camping, or daycare. Again, those kids have greasy, foul-smelling stools with bloating and flatulence. Cryptosporidium is the swimming pool organism. Those oocysts are remarkably resistant to chlorine, so swimming pools, splash pads, and water parks should all get your attention. Those patients usually have profuse watery diarrhea, but in otherwise healthy children, it tends to run its course over a couple weeks. Cyclospora is different because it just hangs around. That's really what makes me think about it. It's not necessarily how sick the kid is, it's that they're still sick when they should actually be getting better. So aside from when you're in the middle of an outbreak, when should you actually suspect it? It's really when a few things start lining up. The diarrhea has lasted more than a week. Maybe it got a little better and then came back. The kid has lost some weight or looks a little dehydrated. It's summertime. The bacterial stool studies are negative. Maybe there's a history of travel. Maybe there isn't. Maybe there's a history of eating fresh produce. Maybe there isn't. At some point, you have to stop saying, “Eh, it's probably still viral,” and start asking yourself whether you're dealing with something else. One teaching point that's worth repeating, partly because it shows up on board exams and partly because it explains the epidemiology, is that Cyclospora isn't spread directly from person to person. Fresh stool isn't immediately infectious because those oocysts still have to sporulate in the environment before they can infect the next person. So let's say you're thinking about Cyclospora. What do you actually order? A routine stool culture isn't gonna help you. Even a routine ova and parasite examination may not be enough. That's an easy mistake to make because a lot of us were taught persistent diarrhea, send culture and O&P or a stool molecular pathogen panel. Many labs don't specifically look for Cyclospora unless you ask them to or order it specifically. So there's gastrointestinal PCRs for it, but you have to order them separately. So you can actually get back a negative O&P and feel reassured when in reality no one's really tested for Cyclospora. If your hospital has a multiplex GI PCR panel that includes it, that's probably what you should order first. If you don't, you probably have to order it separately. Another board pearl. So if you're taking a board exam and they describe a child with prolonged watery diarrhea during the summer, maybe after eating fresh produce, and then they casually mention that the routine ova and parasite examination was negative, don't let that throw you off. That's actually the clue. The organism may still be there, the lab just wasn't sent to look for it. If your lab is using microscopy, Cyclospora can be identified with a modified acid-fast stain. The oocysts are a little larger than Cryptosporidium, and one interesting feature is that they stain variably. Some stain bright red, while others hardly stain at all, giving them that classic ghost organism appearance, which I think is just, like, cool. And because oocyst shedding is intermittent, collecting two or three stool specimens over several days can improve the diagnostic yield if you still have a high index of suspicion. The good news is that once you make the diagnosis, treatment is actually pretty straightforward. Trimethoprim-sulfamethoxazole remains the treatment of choice. In adult-sized patients, that means trimethoprim one hundred and sixty milligrams plus sulfamethoxazole eight hundred milligrams, just one double-strength tablet, orally twice a day for seven to ten days. For kids greater than two months of age to eighteen years, it's eight to ten milligrams per kilogram trimethoprim and forty to fifty milligrams per kilogram sulfamethoxazole per day orally in two divided doses for seven to ten days. Most children begin feeling noticeably better within twenty-four to forty-eight hours. Honestly, this can be a pretty satisfying infection to treat because families have often been searching for an answer for a week or two. They've been told it's viral. They've been waiting for it to improve, and then you finally make the diagnosis within a day or two of starting the right antimicrobial, the kid's turning the corner. If the kid has a true sulfonamide allergy, things are a little more complicated, and I mean a true allergy, not just the parent who says, “Well, my mother was allergic to sulfa, so we've always avoided it.” There really isn't a perfect alternative. At this point, I'm probably talking to ID. Nitazoxanide's been used, ciprofloxacin's been used, but we generally try to avoid fluoroquinolones in children. Neither has been shown to work as well as trim-sulfa. And if you've got somebody who's immunocompromised with Cyclospora, which fortunately I've never seen, I'd be calling ID. Of course, don't forget everything else that goes along with taking care of prolonged diarrhea. Oral rehydration is still the goal whenever possible. Some kids are gonna need IV fluids because by the time they get to you, they've been losing fluid for days. Replace electrolytes if they've been really sick. And if the illness has dragged on for a couple of weeks, don't forget the nutritional burden. Sometimes they've lost enough weight that getting them eating and drinking normally again becomes part of an ongoing treatment plan. The good news is that most otherwise healthy children recover completely. Immunocompromised patients are the group that worries us the most. Their symptoms can become prolonged. They can relapse. Sometimes they require longer admissions or even secondary prophylaxis. One question that occasionally comes up is whether you need to repeat stool testing after treatment. In general, you don't. If the kid's symptoms have resolved, then you don't need to prove microbiologic cure. Treat the patient, not the PCR. If the kid feels better, you don't need to prove that the pathogen is gone. So let's get back to that hypothetical scenario we started with, that kid in July that's had watery diarrhea for 10 days. The stool culture was negative. They're starting to lose weight. The parents are frustrated. Everyone keeps telling them it's a virus. Maybe it is another virus. Maybe it's two illnesses in a row. But this is the patient where you have to take a step back and consider just one more test instead of offering more reassurance. That's what Cyclospora is. Of course, you shouldn't suspect it in every single child with prolonged diarrhea, but be aware of whether or not there's an outbreak and test for it. Before wrapping this episode up, here's a few more things I'd like you to remember. One, if watery diarrhea has lasted more than a week, especially during the summer months, make sure Cyclospora is somewhere on your differential. Second, remember my comparison. Greasy diarrhea, think Giardia. Swimming pool exposure and profuse watery diarrhea, think Cryptosporidium. Prolonged watery diarrhea during the summer, think Cyclospora. Third, don't let a negative routine ova and parasite examination or stool molecular pathogen panel falsely reassure you. Make sure your laboratory is actually testing for Cyclospora, and remember that not every GI PCR panel includes it. Finally, once you make the diagnosis, treatment is pretty straightforward. Trimethoprim-sulfamethoxazole for most patients. Kids will start feeling better in 24 to 48 hours. Cyclospora isn't the first diagnosis that comes to mind when a kid has diarrhea, and it shouldn't be. Viral gastro is still far more common. But when the diarrhea has been going on for 10 days, the stool studies are negative, the kid's starting to lose weight, and the family says, “I thought we were finally getting better,” that's when you have to stop and think about Cyclospora. It's the child with the diarrhea that lingered. If you enjoyed this episode, as the kids would say, like, rate, and review. Leaving that review on your favorite podcast platform really does help other people discover the show, and I've been fortunate to be teaching through this podcast since 2013 because of listeners like you. If you got ideas for future episodes or topics you'd like me to cover, I'd love to hear them. For PEM Currents: The Pediatric Emergency Medicine Podcast, this has been Brad Sobolewski. See you next time.  

Alec Ford, CEO of Karius, has developed an innovative approach to diagnosing infections in immunocompromised patients, using DNA sequencing of blood samples to identify over 1,300 causes of infection within 24 hours. Traditional diagnostic methods rely on hypothesis-driven testing and the cultivation of organisms. At the same time, the Karius approach enables faster, more targeted antibiotic treatment, reduces unnecessary broad-spectrum antibiotics, and can identify infections that may not be included in the initial diagnosis. Time to proper treatment is essential for vulnerable populations, including cancer patients, HIV-positive individuals, organ transplant recipients, and those undergoing autoimmune therapies.  Alec explains, "These are patients going through cancer treatment, patients with HIV, people going through solid organ transplantation, or people being treated assertively with autoimmune therapies for autoimmune disorders, where it may compromise their immune system. That really vulnerable patient is our exclusive focus as a company."   "So, a patient gets admitted to the hospital for an infection. They take a sample of that patient's blood. And what we can do is diagnose over 1,300 causes of infection by sequencing the patient's blood for viruses, parasites, bacteria, and fungi that could threaten the success of their cancer treatment or solid organ transplant. There's never been a test in the history of infectious disease that can test for any DNA-based organism, and we do so. We can return a result 24 hours after we receive the sample."   #Karius #InfectiousDisease #Diagnostics #Metagenomics #MedTech #KariusSpectrum #KariusFocus #NextGenSequencing #ImmunocompromisedCare #Oncology #TransplantMedicine #AntimicrobialStewardship #Genomics #MolecularDiagnostics #KariusTest #PatientSafety #HealthcareInnovation Kariusdx.com  Download the transcript here

Alec Ford, CEO of Karius, has developed an innovative approach to diagnosing infections in immunocompromised patients, using DNA sequencing of blood samples to identify over 1,300 causes of infection within 24 hours. Traditional diagnostic methods rely on hypothesis-driven testing and the cultivation of organisms. At the same time, the Karius approach enables faster, more targeted antibiotic treatment, reduces unnecessary broad-spectrum antibiotics, and can identify infections that may not be included in the initial diagnosis. Time to proper treatment is essential for vulnerable populations, including cancer patients, HIV-positive individuals, organ transplant recipients, and those undergoing autoimmune therapies.  Alec explains, "These are patients going through cancer treatment, patients with HIV, people going through solid organ transplantation, or people being treated assertively with autoimmune therapies for autoimmune disorders, where it may compromise their immune system. That really vulnerable patient is our exclusive focus as a company."   "So, a patient gets admitted to the hospital for an infection. They take a sample of that patient's blood. And what we can do is diagnose over 1,300 causes of infection by sequencing the patient's blood for viruses, parasites, bacteria, and fungi that could threaten the success of their cancer treatment or solid organ transplant. There's never been a test in the history of infectious disease that can test for any DNA-based organism, and we do so. We can return a result 24 hours after we receive the sample."   #Karius #InfectiousDisease #Diagnostics #Metagenomics #MedTech #KariusSpectrum #KariusFocus #NextGenSequencing #ImmunocompromisedCare #Oncology #TransplantMedicine #AntimicrobialStewardship #Genomics #MolecularDiagnostics #KariusTest #PatientSafety #HealthcareInnovation Kariusdx.com  Listen to the podcast here

The COVID-19 public health emergency may be over, but for millions of Americans with weakened immune systems, the virus remains a serious concern. In this episode of The Health Advocates, Steven Newmark breaks down a recent announcement from the U.S. Department of Health and Human Services to phase out COVID-19 Emergency Use Authorizations (EUAs) and explains why the decision matters for people who are immunocompromised. The transition will require the FDA to establish new regulatory pathways for certain COVID-19 drugs and biologics over the coming year, raising important questions about how patients will continue to access preventive therapies during that process. Steven explains what an EUA is, why some immunocompromised patients need additional protection beyond vaccination, and why patient voices are essential as the FDA considers its next steps. Most importantly, he discusses how thoughtful patient advocacy can help ensure that regulatory decisions remain focused on science, continuity of care, and the needs of those who remain most vulnerable to COVID-19. Whether you're living with a chronic illness, caring for someone who is immunocompromised, or simply interested in how health policy affects patient care, this episode offers an accessible look at an important issue that could shape COVID-19 prevention for years to come. Contact Our HostSteven Newmark, Chief of Policy at GHLF: snewmark@ghlf.orgA podcast episode produced by Amelia Violet Prouse, Associate Podcast & Video Producer at GHLF.We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.orgListen to all episodes of The Health Advocates on our website or on your favorite podcast channel.See omnystudio.com/listener for privacy information.

Dr. Don and Professor Ben talk about the risks from using toaster after splashing raw chicken juice inside if you are immunocompromised. Dr. Don - not risky

🧭 REBEL Rundown 📌 Key Points 💨 HFNC met criteria for non-inferiority to BPAP for preventing intubation or death within 7 days in four of the five ARF subgroups.🧪 Bayesian dynamic borrowing increased power across subgroups but created variable certainty, especially in smaller groups such as COPD.🫁 The immunocompromised hypoxemia subgroup did not meet non-inferiority, leading to early trial stopping for futility.️ Rescue BPAP use, subgroup-specific exclusion criteria, and non-standardized BPAP delivery are important contextual factors that influence how subgroup results should be interpreted. Click here for Direct Download of the Podcast. 📝 Introduction Bilevel Positive Airway Pressure (BPAP) has long been a foundational modality in the management of acute respiratory failure (ARF), particularly in COPD exacerbations and cardiogenic pulmonary edema, where it can rapidly reduce work of breathing and improve gas exchange. It remains a core tool in our respiratory support arsenal.High-flow nasal cannula (HFNC), however, has expanded what we can offer patients by delivering many of the same physiologic benefits through a far more comfortable interface. With high flows, modest PEEP, and effective dead-space washout, HFNC can improve oxygenation and decrease work of breathing while preserving the ability to talk, cough, eat, and interact with staff and family. This combination of physiologic support and tolerability makes HFNC especially attractive in patients where comfort, anxiety, or cardiovascular stability are key considerations, and in settings where prolonged noninvasive support may be needed. Rather than competing with BPAP, HFNC broadens our options in ARF and allows us to better match the modality to the patient and their underlying disease process.The RENOVATE trial set out to answer a high-impact question across five distinct etiologic groups: Is HFNC non-inferior to BPAP (NIV) for preventing intubation or death in acute respiratory failure? 🧾 Paper Azoulay É, et al. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA. 2025 PMID: 39657981 🔙Previously Covered On REBEL: HFNC: Part 1 – How It WorksHFNC: Part 2 – Adult and Pediatric IndicationsFLORALI and AVOID TrialFLORALI-2: NIV vs HFNC as Pre-Oxygenation Prior to IntubationThe Pre-AeRATE Trial – HFNC vs NC for RSI ️ What They Did CLINICAL QUESTION Is HFNC non-inferior to BPAP for rate of endotracheal intubation or death at 7 days in patients with acute respiratory failure due to a variety of causes? STUDY DESIGN Multicenter, randomized non-inferiority trial33 Brazilian hospitalsNov 2019 – Nov 2023Adaptive Bayesian hierarchical modeling with dynamic borrowingOpen label, outcome adjudicators blindedPatients were classified into 5 subgroups SUBGROUPS 1. Non-immunocompromised hypoxemiaSpO₂ < 90% on room air orPaO₂ < 60 mm Hg on room air plusIncreased respiratory effort (accessory muscle use, paradoxical breathing, thoracoabdominal asynchrony) orRespiratory rate > 25 breaths/min2. Immunocompromised hypoxemiaDefined as:Use of immunosuppressive drugs for >3 monthsOR high-dose steroids >0.5 mg/kg/dayOR solid organ transplantOR solid tumors or hematologic malignancies (past 5 years)OR HIV with AIDS / primary immunodeficiency3. COPD exacerbation with acidosisHigh clinical suspicion of COPD as primary diagnosisRR >25 with accessory muscle use, paradoxical breathing, and/or thoracoabdominal asynchronyABG: pH 454. Acute cardiogenic pulmonary edema (ACPE)Sudden onset dyspnea and rales± S3 heart soundNo evidence of aspiration, infection, or pulmonary fibrosisCXR consistent with pulmonary edema5. Hypoxemic COVID-19 (added June 2023)Added due to deviations between expected and observed outcome proportionsAny patient across the other 4 groups with PCR-confirmed SARS-CoV-2 infection in any of the above groups POPULATION Inclusion Criteria:≥18 yrs with ARF* in one of 5 pre-defined subgroups excluding COPD was defined by the following:Hypoxemia with SpO₂

David Dodd, CEO of GeoVax,  highlights the need for next-generation vaccines, specifically multi-antigen and T cell-focused technologies, to provide better protection for immunocompromised populations. Their pipeline includes a COVID-19 vaccine candidate, an Mpox/Smallpox vaccine, and a gene therapy for solid tumors. A priority for GeoVax is to develop new manufacturing processes to significantly accelerate vaccine production, increase yield, and reduce costs. David explains, "Multi-antigen vaccines become critically important, especially for populations for whom the existing approach in vaccines, meaning single-antigen vaccines or antibody-focused or antibody-only vaccines, is inadequate. And to clarify that, there are approximately 40 million adults in the United States, about 10 times that number worldwide, who suffer from various medical conditions, such as blood cancers. They may have renal disease, diabetes, or be HIV positive. They may also have weakened immune systems, they could have multiple sclerosis or lupus. So there are a host of medical conditions that the result is they inhibit or they deplete an individual's immune system from mounting an adequate antibody response. And keep in mind, the antibody system is that first line of defense when an infectious threat occurs. And that's sort of like the frontline soldiers. They throw up a protective guard to respond to that." "That means for those individuals, what we need to do is also address this, as we develop vaccines, and some technologies allow you to do this. The majority of vaccine platforms do not, unfortunately. And that is to also induce a very strong cellular immunity or T cells. And this becomes critically important because T cells are what clear a virus from the body. It's also what drives what is known as memory, and also gives breadth or robustness of protection. So it becomes critically important that if one has the opportunity because of their technology or the platform they're utilizing to enlist and engage both the antibody as well as the cellular side, then one can generally develop a much more robust protective immune response that will reduce the risk of severe infection, hospitalization, and the risk of death against certain infections." #GeoVax #Biotech #Vaccines #PublicHealth #Healthcare #COVID19 #LifeSciences #Biotechnology #Mpox #GlobalHealth  geovax.com Download the transcript here

David Dodd, CEO of GeoVax,  highlights the need for next-generation vaccines, specifically multi-antigen and T cell-focused technologies, to provide better protection for immunocompromised populations. Their pipeline includes a COVID-19 vaccine candidate, an Mpox/Smallpox vaccine, and a gene therapy for solid tumors. A priority for GeoVax is to develop new manufacturing processes to significantly accelerate vaccine production, increase yield, and reduce costs. David explains, "Multi-antigen vaccines become critically important, especially for populations for whom the existing approach in vaccines, meaning single-antigen vaccines or antibody-focused or antibody-only vaccines, is inadequate. And to clarify that, there are approximately 40 million adults in the United States, about 10 times that number worldwide, who suffer from various medical conditions, such as blood cancers. They may have renal disease, diabetes, or be HIV positive. They may also have weakened immune systems, they could have multiple sclerosis or lupus. So there are a host of medical conditions that the result is they inhibit or they deplete an individual's immune system from mounting an adequate antibody response. And keep in mind, the antibody system is that first line of defense when an infectious threat occurs. And that's sort of like the frontline soldiers. They throw up a protective guard to respond to that." "That means for those individuals, what we need to do is also address this, as we develop vaccines, and some technologies allow you to do this. The majority of vaccine platforms do not, unfortunately. And that is to also induce a very strong cellular immunity or T cells. And this becomes critically important because T cells are what clear a virus from the body. It's also what drives what is known as memory, and also gives breadth or robustness of protection. So it becomes critically important that if one has the opportunity because of their technology or the platform they're utilizing to enlist and engage both the antibody as well as the cellular side, then one can generally develop a much more robust protective immune response that will reduce the risk of severe infection, hospitalization, and the risk of death against certain infections." #GeoVax #Biotech #Vaccines #PublicHealth #Healthcare #COVID19 #LifeSciences #Biotechnology #Mpox #GlobalHealth  geovax.com Listen to the podcast here

In this episode, we speak with Synary Be, a resilient survivor of acute myeloid leukemia (AML), who shares her powerful journey of enduring three bone marrow transplants over eight years. Diagnosed suddenly in March 2017, Synary's story begins with a high fever that led to a shocking diagnosis: 93% leukemia. From that point on, her life transformed into a series of hospital stays, treatments, and moments that tested her strength and spirit.We learn how her first transplant involved two umbilical cord donors, one from the U.S. and another from Singapore. When that failed to graft, her younger brother flew from Australia to donate for her second transplant—a 50% match. After two years in remission, she relapsed again and required a third transplant, this time from her older brother, right in the midst of the COVID-19 pandemic. With travel restrictions in place, the donor cells had to be processed remotely and shipped to Stanford, showcasing the remarkable role of medical technology in saving lives.Despite being given only a 50% chance of survival for her third transplant, Synary put her trust in her doctors. Though she relapsed again, she now maintains remission through chemo pills. With no long-term data available for this new medication, she continues treatment cautiously and with optimism, trusting in the advancement of medicine.Synary spends some time opening up about the chronic graft-versus-host disease (GVHD) that followed her transplants. She explains its impact on her lungs, eyes, mouth, nails, and skin, detailing both the physical symptoms and the treatments that have helped her reclaim daily life. From scleral lenses to serum tears, to pulmonary rehab and steroid creams, she educates us on the challenges and management of GVHD.Beyond the physical toll, Synary discusses the mental health struggles tied to long-term illness—particularly anxiety from repeated hospitalizations. She emphasizes the importance of therapy, meditation, support groups, and the courage to seek help. Her words serve as a reminder that managing chronic illness includes caring for both mind and body.Synary's story wouldn't be complete without acknowledging her support system. Her husband, who acted as her full-time caregiver through 300 cumulative days of hospitalization, and her three children, endured major sacrifices. Friends and community support filled in the gaps, underscoring that no one should navigate transplant recovery alone.Even in the face of isolation, fatigue, and anxiety, Synary finds joy in simple pleasures: watching Christmas movies, going for walks, and spending time with family. Her message is clear—life is still good. And GVHD, while challenging, cannot take away her joy.Calm App — https://www.calm.comThanks to our Season 19 sponsors, Incyte and Sanofi.https://incyte.com/https://www.sanofi.com/en00:40 - Introduction to Synary Be01:20 - AML Diagnosis and First Transplant03:10 - Transplants and Donor Challenges04:06 - Relapses and Chemo Maintenance06:44 - Living with GVHD12:15 - GVHD Symptoms and Treatments13:40 - Support System and Caregiving15:34 - Isolation After Transplants16:38 - Mental Health & Anxiety19:03 - Coping and Finding Joy20:36 - Final Thoughts and Message of Hope National Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page: https://www.facebook.com/nbmtLINKFollow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/The nbmtLINK YouTube Page can be found by clicking here.To participate in the GVHD Mosaic, click here: https://amp.livemosaics.com/gvhd Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Don and Professor Ben talk about the risks of unpasteurized apple cider vinegar for pregnant or immunocompromised people. Dr. Don - not risky

Send us a textDr. Robert Allen, PhD is Chief Scientific Officer of Invivyd ( https://www.invivyd.com/ ), a biopharmaceutical company devoted to delivering protection from serious viral infectious diseases, beginning with SARS-CoV-2, by deploying a proprietary integrated technology platform, to create best in class monoclonal antibodies.Dr. Allen brings over 30 years of experience across the infectious disease space, most recently as the Chief Scientific Officer of SmartPharm Therapeutics, a subsidiary of Sorrento Therapeutics. During that time, he led efforts to develop gene-encoded monoclonal antibodies for COVID-19 that could be quickly adapted to respond to emerging variants of concern. He also served concurrently as Senior Vice President, Antiviral and Oncolytic Immunotherapy Development, at Sorrento Therapeutics. Prior to his time at SmartPharm Therapeutics, Dr. Allen held multiple senior scientific roles across the pharmaceutical and biotechnology industries including at Sorrento Therapeutics, SIGA Technologies, and the Oregon Translational Research and Development Institute. Dr. Allen holds a Ph.D. in Microbiology from Columbia University, an M.S. in Applied Biology from Georgia Institute of Technology, and a B.S. in Biology from Rhodes College. He has published extensively in the field of virology and completed his postdoctoral training in virology at Washington University in St. Louis and Emory University.#RobertAllen #Invivyd #Biopharmaceuticals #InfectiousDiseases #SARSCoV2 #MonoclonalAntibodies #Immunocompromised #RareViralEpitopes #Pemivibart #PreExposureProphylaxis #Covid19 #EmergencyUseAuthorization #EUA #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Guest: Leonard Calabrese, DO Preventing serious infections should be a priority when treating patients with immune-mediated inflammatory diseases, especially those receiving immunosuppressive therapies. By assessing patients' level of immunocompetence, clinicians can better tailor vaccination strategies and optimize infection prevention. Hear Dr. Leonard Calabrese discuss how to evaluate immunosuppression risk and coordinate timely vaccinations for patients undergoing immunomodulatory treatments. Dr. Calabrese heads the Section of Clinical Immunology at the Cleveland Clinic in Ohio, where he manages the Clinical Immunology Clinic and is on the staff of the Department of Rheumatic and Immunologic Diseases. He also spoke on this topic at the 2025 Congress of Clinical Rheumatology West conference.

Guest: Leonard H. Calabrese, DO Preventing serious infections should be a priority when treating patients with immune-mediated inflammatory diseases, especially those receiving immunosuppressive therapies. By assessing patients' level of immunocompetence, clinicians can better tailor vaccination strategies and optimize infection prevention. Hear Dr. Leonard Calabrese discuss how to evaluate immunosuppression risk and coordinate timely vaccinations for patients undergoing immunomodulatory treatments. Dr. Calabrese heads the Section of Clinical Immunology at the Cleveland Clinic in Ohio, where he manages the Clinical Immunology Clinic and is on the staff of the Department of Rheumatic and Immunologic Diseases. He also spoke on this topic at the 2025 Congress of Clinical Rheumatology West conference.

In this episode, we talk with David Hartley, PhD, MPH, who shares his deeply personal experience as both a caregiver and a scientist. David is chair of the board for Engraft, a learning network focused on improving outcomes in transplant and cellular therapy through collaboration and shared data. While he brings professional expertise in infectious diseases and epidemiology, our conversation centers on his journey as a father navigating his son Devin's stem cell transplant at age 13.We begin by discussing Devin's sudden diagnosis after months of unexplained symptoms. Despite initial medical dismissal, David's persistence—fueled by his medical background—led to a hematologist visit that quickly changed everything. From that point, their lives became dominated by a rapid series of decisions leading to a bone marrow transplant at a center hours from home. With a second child, sick parent, and full-time jobs, David and his wife adopted a "divide and conquer" strategy: she managed Devin's care in-hospital, while he held down things at home.Throughout, David stresses the overwhelming nature of transplant. It's relentless and multifaceted—emotionally, logistically, and financially. His wife tracked medications, schedules, and insurance battles. One notable success was avoiding a lawsuit thanks to her meticulous record-keeping and strong communication with their insurance provider. David's role included managing home infusions and learning as much as possible about the transplant process to mitigate risks, particularly infections. They juggled roles and adapted constantly, ensuring redundancy in caregiving in case one of them became unavailable.We delve into the emotional toll and the universality of caregiver fatigue. David admits to not managing his own stress well, noting long-term impacts. He discusses a study linking chronic stress to telomere shortening (he explains what that is- see below for the link), highlighting the physical consequences of caregiver strain. Still, he emphasizes the importance of accepting help and finding moments for self-care, however small.David shares powerful insights on advocacy, highlighting it as a team effort rather than a confrontation. He and his wife advocated for Devin's pain management, educational access, and protection from medical errors. He stresses the value of caregivers' unique skills and the importance of focusing on the outcomes that matter most to each family—whether clinical or social.Later in the episode, David offers a scientist's perspective on the variability in patient outcomes and the limitations of statistics in predicting individual experiences. His reflections underscore the complexity of transplant medicine and the value of shared data systems like Engraft. He also reminds us not to panic over single research findings, advocating for a balanced, critical view of medical literature.We close with the good news: Devin is now a healthy, wise young adult. David expresses deep gratitude to the care teams and support networks that helped them through. His story is a testament to resilience, collaboration, and the essential role of caregivers in the transplant journey.Engraft: www.engraftlearningnetwork.orgTriage Cancer: https://triagecancer.orgAARP article about Telomore:  https://www.aarp.org/health/conditions-treatments/elizabeth-blackburn-stress-dna-hd/Thanks to our Season 17 Sponsors:Leukemia and Lymphoma Society (LLS): https://lls.org/and Incyte: https://incyte.com/ National Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page: https://www.facebook.com/nbmtLINKFollow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/The nbmtLINK YouTube Page can be found by clicking here.To participate in the GVHD Mosaic, click here: https://amp.livemosaics.com/gvhd

Bianca Brandon, Senior Editor at The Lancet Respiratory Medicine, is joined by Professor Hjalmar Bouma to discuss a new review on sepsis in immunocompromised patients, exploring the diagnostic challenges, complexities of immune status, and future directions for targeted therapies. The episode also analyses the increased vulnerability of specific patient groups, the importance of biomarker-driven personalised medicine, and the need for improved representation of immunosuppressed patients in clinical trials. Read the full article:https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00124-9/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lanresContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Title: Vaccinating the Immunocompromised: Unintended Consequences and Medical Ethics Presenters: Dr. Paul Thomas, Brian Hooker, PhD Length: Approximately 27 minutes ________________________________________ Web Resources Discussed • Doctors and Science: https://www.doctorsandscience.com/ • Kids First 4Ever: https://www.kidsfirst4ever.com/#/ • VAX FACTS (Paperback): https://indiepubs.com/products/vax-facts/ • VAX FACTS (eBook): https://www.kidsfirst4ever.com/store/p8/VAX-FACTS-EPUB.html • Vax-Unvax: Let the Science Speak: https://www.skyhorsepublishing.com/9781510776591/vax-unvax/ • Save Alexis Fundraiser: https://givebutter.com/savealexis • Alexis Lorenze Injury Article – Children's Health Defense: https://childrenshealthdefense.org/defender/alexis-lorenze-multiple-vaccines-injury/ • CHD.TV Live Update – Alexis Lorenze: https://live.childrenshealthdefense.org/chd-tv/events/the-peoples-study/alexis-lorenze-live-update-092324/ • CHD.TV Update – Grave Condition: https://live.childrenshealthdefense.org/chd-tv/events/the-peoples-study/update-23yearold-in-grave-condition/ • CHD.TV Breaking News – Grave Condition: https://live.childrenshealthdefense.org/chd-tv/events/the-peoples-study/breaking-news-23yearold-in-grave-condition/ ________________________________________ Key Points (with timestamps) 00:00:40 – VAX FACTS Announcement Dr. Paul shares the release of VAX FACTS, the new paperback guide for families making informed vaccine decisions. 00:01:16 – Meet Brian Hooker, PhD Dr. Paul welcomes Dr. Brian Hooker, co-author of Vax-Unvax, to discuss what happens when fragile patients are forced into unsafe medical decisions. 00:03:12 – Alexis Lorenze's Tragic Story Brian Hooker recounts the heartbreaking case of 23-year-old Alexis Lorenze, who suffered catastrophic health consequences after a hospital mandated vaccines prior to treating her autoimmune condition. The conversation explores what happened to her and the consequences of ignoring individualized medical risk. 00:11:14 – The Ethics of Vaccinating the Immunocompromised Hooker reveals that vaccines are largely untested in immunocompromised individuals and that forcing these shots amounts to unconsented human experimentation. 00:18:06 – Im

Dr. Rod Quilitz, infectious diseases pharmacotherapist at the Moffitt Cancer Center and Research Institute, presents his talk regarding the infectious diseases syndromes likely to be encountered when managing ID complications in an immunocompromised population. Dr. Quilitz begins by discussing risk factors for infection. He then goes on to discuss neutropenic fever management. The contrast between low grade and high grade neutropenia is also differentiated. Next, Dr. Quilitz discusses strategies for prophylaxis of patients who have prolonged neutropenia, including the use of gram positive antimicrobial agents and antifungals. Other subjects covered include the spectrum of CART toxicities, immune reconstitution, prophylaxis for Pneumocystis, CMV disease/prophylaxis, and other viral infections in the immunocompromised population.

This week on Health Matters, Courtney Allison is joined by infectious disease expert from NewYork-Presbyterian and Columbia, Dr. Marcus Pereira, to learn what we need to know about bird flu.Dr. Pereira explains that while the cases of bird flu in humans have been mostly mild, there is still a risk that the virus could mutate and spread more easily from human-to-human. He talks about ways to protect ourselves from bird flu, and explains whether it's safe to eat eggs, meat and other dairy products.___Dr. Marcus Pereira is an Associate Professor of Medicine at CUMC and the Director of Clinical Services in the Division of Infectious Diseases. In addition, he is the Medical Director of the Transplant Infectious Diseases Program, where he oversees the development of infection prophylaxis and treatment protocols for immunocompromised patients. His areas of interest include the management of multi-drug resistant bacterial and fungal infections, as well as drug resistant CMV infections and more recently the impact of COVID-19 in transplant recipients. He has also collaborated in important multi-center studies as well as the 2025 International CMV Guidelines, sponsored by the Transplantation Society. Dr. Pereira is an active member in national societies such as the American Society of Transplantation and Infectious Disease Society of America, and is an Associate Editor for the American Journal of Transplantation.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine. To learn more visit: https://healthmatters.nyp.org

About this episode: In the early days of the COVID-19 pandemic when there were no vaccines or treatments, convalescent plasma—antibody-containing blood from people who recovered from COVID—saved countless lives through Emergency Use Authorization. In this episode: special guest host Thomas Locke of MMI Monthly: From Bench To Breakthrough discusses the evolution of CCP therapy, from emergency use during the pandemic to now, nearly five years later, crossing the finish line with recent FDA approval as a potential treatment for immunocompromised patients. Guest: David Sullivan is a professor in Molecular Microbiology and Immunology and a researcher at the Johns Hopkins Malaria Research Institute. Host: Thomas Locke is the host of MMI Monthly: From Bench to Breakthrough and Malaria Minute,  podcasts from the department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. Show links and related content: Bloomberg School Researchers Support First Blood Center to Receive Full FDA Approval to Provide Convalescent Plasma for Patients Who Are Immunocompromised—Johns Hopkins Bloomberg School of Public Health Convalescent Plasma Offers ‘Blueprint' For Future Pandemics—The Hub How a Boy's Blood Stopped an Outbreak—The Wall Street Journal (Opinion) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌JohnsHopkinsSPH on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Listen in as Cristina Mussini, MD; Martin Witzenrath, MD, FERS; and Michele Bartoletti, MD, PhD, discuss treatment strategies for people who are immunocompromised with COVID-19 in the hospital setting, including: Antiviral therapy with remdesivirDexamethasone for patients with hematologic malignanciesConsiderations regarding other immunomodulators such as JAK inhibitors or IL-6 inhibitorsA detailed patient case to illustrate key takeaways Presenters:Michele Bartoletti, MD, PhD​Associate Professor of Infectious DiseasesDepartment of Biomedical SciencesHumanitas UniversityPieve Emanuele (MI), ItalyHead of Infectious Diseases UnitIRCCS Humanitas Research HospitalRozzano (MI), ItalyCristina Mussini, MD​Full Professor of Infectious DiseasesChief of the Department of Infectious DiseasesUniversity of Modena and Reggio EmiliaModena, ItalyMartin Witzenrath, MD, FERS Medical DirectorCharite Centrum 12Internal Medicine & DermatologyProfessor and Chair for Respiratory Medicine and Critical CareDepartment of Infectious Disease, Respiratory Medicine and Critical CareCharite Campus Mitte/Campus Virchow Klinikum/Campus Benamin FranklinCharite – University of BerlinBerlin, GermanyLink to full program:https://bit.ly/4fs7HcbDownloadable slides:https://bit.ly/3XP1fpJGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss treatment strategies for people who have severe COVID-19, including: Antiviral therapy with remdesivir Dexamethasone and other systemic corticosteroids Immunomodulators, such as JAK inhibitors or IL-6 inhibitors Overviews of clinical trial data demonstrating how and when to use these therapiesPresenters:Stephen Cantrill, MD, FACEP​Associate Director and Medical Director (Retired) ​ Department of Emergency Medicine​ Denver Health Medical Center​ Associate Professor ​ Department of Emergency Medicine​ University of Colorado Health Sciences Center​ Denver, Colorado Rajesh T. Gandhi, MD​Massachusetts General Hospital​ Professor of Medicine​ Harvard Medical School​ Boston, Massachusetts Payal K. Patel, MD, MPH, FIDSA​Systemwide Director of Antimicrobial Stewardship​ Associate Professor, Division of Infectious Diseases​ Intermountain Health​ Salt Lake City, Utah Link to full program: https://bit.ly/4gu2gcUGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.    

In this episode, Martin Witzenrath, MD, FERS, and Michele Bartoletti, MD, PhD, discuss the management of mild to moderate COVID-19 in patients who are immunocompromised, including:Initial workup, which may include laboratory tests and/or imagingLatest data on the use of remdesivir or nirmatrelvir plus ritonavir for mild to moderate COVID-19, including considerations for drug–drug interactions Presenters:Martin Witzenrath, MD, FERSMedical DirectorCharite Centrum 12Internal Medicine & DermatologyProfessor and Chair for Respiratory Medicine and Critical CareDepartment of Infectious Disease, Respiratory Medicine and Critical CareCharite Campus Mitte/Campus Virchow Klinikum/Campus Benjamin FranklinCharite – University of BerlinBerlin, GermanyMichele Bartoletti, MD, PhDAssociate Professor of Infectious DiseasesDepartment of Biomedical SciencesHumanitas UniversityPieve Emanuele (MI), ItalyHead of Infectious Diseases UnitIRCCS Humanitas Research HospitalRozzano (MI), Italy Link to full program: https://bit.ly/4gu2gcUDownloadable slides: https://bit.ly/3CGlDBSGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In this episode, Cristina Mussini, MD, Martin Witzenrath, MD, FERS, and Michele Bartoletti, MD, PhD, discuss:Current SARS-CoV-2 trends in the EURisk factors for severe COVID-19 outcomes, including the spectrum of risk based on immune system statusFactors that may affect vaccine efficacy in chronic lymphocytic leukemia and other lymphoid malignanciesConsiderations for determining people at high risk for COVID-19 progression Presenters:Cristina Mussini, MDFull Professor of Infectious DiseasesDivision of Infectious DiseasesUniversity of Modena and Reggio EmiliaModena, ItalyMartin Witzenrath, MD, FERSMedical DirectorCharite Centrum 12Internal Medicine & DermatologyProfessor and Chair for Respiratory Medicine and Critical CareDepartment of Infectious Disease, Respiratory Medicine and Critical CareCharite Campus Mitte/Campus Virchow Klinikum/Campus Benjamin FranklinCharite – University of BerlinBerlin, GermanyMichele Bartoletti, MD, PhDAssociate Professor of Infectious DiseasesDepartment of Biomedical SciencesHumanitas UniversityPieve Emanuele (MI), ItalyHead of Infectious Diseases UnitIRCCS Humanitas Research HospitalRozzano (MI), ItalyLink to full program: https://bit.ly/4gu2gcUDownloadable slides: https://bit.ly/42IlpELGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

Human Metapneumovirus (HMPV) is a respiratory virus belonging to the Paramyxoviridae family, closely related to respiratory syncytial virus (RSV). Discovered in 2001, it is a common cause of upper and lower respiratory tract infections across all age groups but is particularly severe in vulnerable populations, such as young children, the elderly, and individuals with weakened immune systems. HMPV spreads through respiratory droplets, direct contact with contaminated surfaces, or close contact with infected individuals. Symptoms typically include cough, nasal congestion, shortness of breath, fever, and, in severe cases, wheezing or bronchitis. In immunocompromised individuals—such as those undergoing chemotherapy, transplant recipients, or those with autoimmune conditions—HMPV can lead to more severe complications, including pneumonia, respiratory failure, or secondary bacterial infections. The lack of specific antiviral treatments or vaccines for HMPV heightens the risk for these groups. Management relies on supportive care, including oxygen therapy and vigilant monitoring for complications. Preventative measures, such as rigorous hand hygiene, wearing masks, and minimizing exposure to symptomatic individuals, are critical to reducing transmission. Due to its potential for severe outcomes in immunocompromised individuals, early recognition and intervention are essential. Awareness of HMPV's impact can aid in improving health outcomes and guiding public health measures.

On this episode, we discuss the prevention and management of opportunistic infections in patients with HIV and other immunocompromising conditions. We provide an overview of the various strategies for managing common OIs, including pharmacological treatments and preventive measures. We also compare and contrast the efficacy, safety profiles, and appropriate use of antibiotic/antifungal therapies used for preventing and treating OIs.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you're not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to this podcast. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. If you purchase an annual membership, you'll also get a free digital copy of High-Powered Medicine 3rd edition by Dr. Alex Poppen, PharmD. HPM is a book/website database of summaries for over 150 landmark clinical trials.You can visit our Patreon page at the website below:  www.patreon.com/corconsultrx We want to give a big thanks to Dr. Alex Poppen, PharmD and High-Powered Medicine for sponsoring the podcast..  You can get a copy of HPM at the links below:  Purchase a subscription or PDF copy - https://highpoweredmedicine.com/ Purchase the paperback and hardcover - Barnes and Noble website We want to say thank you to our sponsor, Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx We also want to thank our sponsor Freed AI. Freed is an AI scribe that listens, prepares your SOAP notes, and writes patient instructions. Charting is done before your patient walks out of the room. You can try 10 notes for free and after that it only costs $99/month. Visit the website below for more information: https://www.getfreed.ai/  If you have any questions for Cole or me, reach out to us via e-mail: Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com

Dr. Don and Professor Ben talk about the risks faced by an immunocompromised person eating mac and cheese left at room temperature for two hours Dr. Don - not risky

In this episode, we're breaking down the current viral landscape, focusing on COVID-19, mpox, norovirus, bird flu, and pertussis. We will discuss the unique challenges these viruses pose to immunocompromised individuals and offer practical advice on how to stay protected from viruses during this hot summer. We also recap the recommendations from the recent ACIP meeting, the advisory committee to the CDC on vaccines. Among the highlights in this episode: 01:10: Zoe Rothblatt, Director of Community Outreach at GHLF, begins the discussion on the current state of COVID-19, noting that while cases are rising, the levels are still much lower compared to the pandemic's peak 02:11: Steven Newmark, Chief of Policy at GHLF, discusses the emergence of new COVID-19 variants and the importance of adapting vaccinations to combat these changes effectively 03:16: Our hosts talk about the specific challenges facing Hawaii, including higher COVID-19 rates possibly due to less community immunity and challenges in vaccine distribution 05:22: Zoe highlights the rise in norovirus cases and reminds listeners about the simple yet effective measure of handwashing to prevent spread 07:13: Steven updates on the latest bird flu cases, reassuring that the transmission remains from animals to humans, not between humans 08:19: The discussion shifts to the ongoing heatwave, with advice on how medications might interact with high temperatures and the importance of staying hydrated 09:53: Steven provides a summary of the latest CDC recommendations for vaccinations, including the new directives for COVID-19, RSV, and pneumococcal vaccines 11:09: What our hosts learned from this episode Contact Our Hosts Steven Newmark, Chief of Policy at GHLF: snewmark@ghlf.org Zoe Rothblatt, Director of Community Outreach at GHLF: zrothblatt@ghlf.org A podcast episode produced by Ben Blanc, Associate Director, Digital Production and Engagement at GHLF. We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.org Catch up on all our episodes on our website or on your favorite podcast channel.See omnystudio.com/listener for privacy information.

Send us a Text Message.Trauma patients are the pinnacle of emergent care, What we have to consider is the process of treating them in the acute setting while preparing them for future care. This might include wound care, documentation, timely getting a concise history, or many other things. As providers, we struggle with parallel vision frequently so we have to be more diligent in the way we see these patients and set them up for success. Support, Follow, or Share the show! ❤️

Dr. Lucy Jessop, Director of the National Immunisation Office at the HSE

March marks four years since the beginnings of the COVID-19 pandemic. Public health failures and government inaction have forced communities to take matters into their own hands. On today's show, we look at two groups steeped in the values of community care. First, we'll hear about the Auntie Sewing Squad, which distributed over 350,000 hand-sewn masks to communities in 2020-2021. Then, we'll speak with organizers from Pandemic Solidarity for the Long Future, which is working today towards a safer future for everyone. Learn more about the story and find the transcript on radioproject.org. Making Contact is an award-winning, nationally syndicated radio show and podcast featuring narrative storytelling and thought-provoking interviews. We cover the most urgent issues of our time and the people on the ground building a more just world. EPISODE FEATURES: Kristina Wong, founder of the Auntie Sewing Squad; J Mase III, organizer with Pandemic Solidarity for the Long Future; and Gata, organizer with Pandemic Solidarity for the Long Future. MAKING CONTACT: This episode is hosted by Lucy Kang. It is produced by Anita Johnson, Lucy Kang, Salima Hamirani, and Amy Gastelum. Our executive director is Jina Chung.  MUSIC: This episode includes "Background Documentary Piano" by SigmaMusicArt via Pixabay. Learn More: Kristina Wong "Kristina Wong, Sweatshop Overlord" at ACT in San Francisco Pandemic Solidarity for the Long Future Home Test to Treat offers free tests and free treatment for COVID-19 and flu at home

The Washington Post released a story that the CDC is considering replacing the COVID five-day isolation period guidance with staying home until 24 hours fever free and improving symptoms. In this episode, we're breaking down all we do and don't know so far about COVID, its impact, and this potential change in recommendation from the CDC. In the news highlights, we discuss how unfortunately two million Texans have lost Medicaid coverage, and we also share the latest results on our quick poll on the patient experience with clinical trials. Among the highlights in this episode: 00:39: Zoe, Associate Director of Community Outreach at GHLF, explains that over two million people have been dropped from Medicaid in Texas, highlighting the significant impact of pandemic policies ending and procedural issues leading to disenrollment 02:22: Our hosts share insights from a GHLF quick poll about clinical trials with 68% of the 2,000 respondents indicating they had not participated in a clinical trial 04:57: Our hosts address leaked information regarding potential changes to CDC isolation guidelines for COVID-19, emphasizing the confusion and lack of official statements 06:14: The conversation shifts to the challenges of accessing COVID tests and the inadequacy of paid sick leave in the U.S., highlighting how these factors complicate the management of COVID-19 08:46: Zoe reflects on the current state of COVID, including declining hospitalizations but lagging booster shot uptake, stressing the ongoing concern for those with chronic illnesses 10:05: Steven Newmark, Director of Policy at GHLF, speculates on the potential impacts of changes to CDC guidance on isolation and masks, considering the general public's adherence to such guidelines 13:44: Our hosts discuss the particular risks COVID-19 poses to immunocompromised individuals and the challenges they face in the workplace 15:25: What our hosts learned from this episodeTo learn more about COVID guidelines and isolation, visit:https://creakyjoints.org/living-with-arthritis/coronavirus/patient-perspectives/covid-guideline-isolation-patient/  Contact Our Hosts Steven Newmark, Director of Policy at GHLF: snewmark@ghlf.org Zoe Rothblatt, Associate Director, Community Outreach at GHLF: zrothblatt@ghlf.org A podcast episode produced by Ben Blanc, Manager of Programs & Special Projects at GHLF. We want to hear what you think. Send your comments in the form of an email, video, or audio clip of yourself to podcasts@ghlf.org Catch up on all our episodes on our website or on your favorite podcast channel.See omnystudio.com/listener for privacy information.

This is a preview of our full episode that you can access over at http://Patreon.com/muckrakepodcast Become a member today and help us maintain our editorial independence as well as unlock a lot of special features like live shows and our private discord.  Jared and Nick cover the latest Trump defense that he says requires Presidents to have absolute immunity to do their jobs. While he's not wrong, it's not to cover war crimes like past presidents, but to grift uncontrollably for self enrichment. They pivot to the New Hampshire primary and how it's Nikki Haley's last stand while Ron DeSantis bails for South Carolina. And they finish with a discussion about the latest events in the Middle East as tensions are high and hostilities are expanding. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Angela Branche, MD, discusses RSV vaccines in older adults, including: Current Advisory Committee on Immunization Practices recommendationsRisk factors associated with severe RSV disease, including RSV-related hospitalizationsApproach to stratifying risk factors (eg, age, comorbidities) in determining which adults may benefit from the RSV vaccine Ongoing research on RSV vaccines in younger adults (eg, aged 40s and 50s years) with chronic comorbidities Health disparities related to RSV vaccinesConsiderations for a risk-based approach, rather than age alone, to determine vaccine candidacy Faculty: Angela Branche, MDAssociate Professor of MedicineDivision of Infectious DiseasesDepartment of MedicineUniversity of RochesterRochester, New YorkLink to full program: https://bit.ly/3nb25xeLink to downloadable slides: https://bit.ly/3TsXym5

This week we will discuss how important it is to continue masking and keeping away from crowds as a chronically ill or immunocompromised person.  Our guest today is Veronica Hanway.  Immunocompromised individuals are not optimally protected by COVID-19 vaccines and potentially require additional preventive interventions to mitigate the risk of severe COVID-19. Veronica, a Latina mother and first generation Geography PhD student in her second year, is 35 years old and has had a lifetime of chronic migraines. With her first migraine at just three years old, she is no stranger to migraine symptoms, MRIs, CTs, neurology appointments, and treatments.  She is an advocate for public health and community care during the ongoing SARS CoV 2 (Covid 19) pandemic. Veronica is committed to protecting her immunocompromised child and her high risk family while also continuing her National Science Foundation Graduate Research Fellowship doctoral studies. Her passions include spending time with her family, advocating for safer spaces for disabled, high risk, immunocompromised, and BIPOC communities, learning how people have adapted to avoiding Covid infections and reinfections, and how people have created Coviding communities. She loves painting, singing, having fun, and reading with her son and partner. She is committed to helping others know that they aren't alone in navigating health issues while the effects of climate change and pandemic rage on.   

Today, I am blessed to have here with me Marek Doyle. He has spent the last 17 years developing a model of individualized nutrition based on data from over 3,000 individual outcomes, 11,000 test findings, and significant utilization of the scientific literature. Marek is a functional nutritional therapist. In addition to his Academy training course for practitioners and enthusiasts in London, England, Marek offers one-on-one consultations for customers. He holds a Master of Science degree in Personalized Nutrition.  Marek has always greatly respected and fascinated with the human body. He was always driven to nutritional therapy since it is the most fundamental aspect in impacting human biochemistry, and he has spent almost two decades improving his methods. Marek has an MSc in Personalized Nutrition (CNELM/Middlesex Uni), as well as a CertHE in Nutritional Medicine, a Diploma in Allergy and Environmental Therapy (BIAET) and a Diploma in Advanced Nutrition for Optimal Health (GBF/BCMA).  His viewpoint is shaped by everything that can enable him to precisely pinpoint each person's major challenges and predict the result of any given option. It is shaped less by exact answers and more by asking the right questions, which are formed from his personal experiences, combining the mechanical knowledge taken from the scientific literature with the wisdom embedded in traditional healing systems, and by making observations gleaned from working directly with thousands of people. In this episode, Marek speaks about how our bodies can repair themselves so long as you identify the hurdles that prevent it from happening, the flaws of modern weight loss methods, the pros and cons of the ketogenic diet, how the mitochondria work under stress, and things you need to remember before going on a diet. This episode originally aired in January 2023. / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Everyday Dose combines the classic coffee flavor you know and love with functional mushrooms, collagen protein, and nootropics to promote focus, energy, immunity, and gut health. No crash. No B.S.. Head to https://everydaydose.superfiliate.com/KETOKAMP  (5 FREE Travel Packs + Free Frother applied) Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [04:50] The Body's Self-Healing Factor The human body will solve its problems unless an obstacle is blocking the way towards healing. Finding out what that obstacle is is the key to overcoming certain health issues. Once these obstacles are taken away, everything becomes much easier for an individual. These interferences aren't easy to identify or solve, which is why it is up to everybody to identify what they are. [06:28] The Flaws of Popular Weight Loss Methods Many influencers, nutritionists, and dieticians claim that energy balance is the only thing you'll need to lose body fat. Calories in and out are a big deal; however, both can change. This concept is entirely dependent on the body not changing its energy usage all day which makes it very flawed. The calorie concept is deceptive because it works short-term for weight loss but not fat loss. There is a massive difference between these two. [12:00] The Pros and Cons of the Keto Diet Two camps are relevant to this diet. The first one is the people who preach that it's a revolution, and the other is the ones who oppose it due to their belief in its health risks. There is a lot of misconception that still exists about the Keto Diet. One of the most anti-inflammatory interventions available is the Ketogenic Diet. [24:47] What the Mitochondria Does When You Are Stressed There are three different types of stress: Mental and Emotional Stress, Physical Stress, and Chemical Stress. Being under any of these stresses will cause the Mitochondria to generate a ton of oxidative stress. The only thing greater than the human body's capability to handle stress is how far you can push it until it eventually fails. Oxidative stress due to the overworking of the Mitochondria will cause certain problems in the human body. [40:44] Things You Must Consider Before Trying Certain Diets       There are many moving parts in the human body, making a perfect diet unrealistic.       Doing certain diets and fasting is fine; however, you must consider your status and other options first.       Stress, Immunocompromised bodies, your home's condition, and most importantly, your current health condition are some of the few things you need to be mindful of before starting a diet that will massively affect your body.   It's always a matter of identifying the big stressors in your life. AND MUCH MORE! Resources from this episode:  Website: https://www.marekdoyle.com Follow Marek Instagram: https://www.instagram.com/marekdoylenutrition  Twitter: https://twitter.com/marekdoyle  Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a  Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ  / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Everyday Dose combines the classic coffee flavor you know and love with functional mushrooms, collagen protein, and nootropics to promote focus, energy, immunity, and gut health. No crash. No B.S.. Head to https://everydaydose.superfiliate.com/KETOKAMP  (5 FREE Travel Packs + Free Frother applied) Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Show notes at pharmacyjoe.com/episode856. In this episode, I’ll discuss the consensus statement published in CHEST on the Treatment of Community-Acquired Pneumonia in immunocompromised patients. The post 856: Treatment of Community-Acquired Pneumonia in immunocompromised patients appeared first on Pharmacy Joe.

Show notes at pharmacyjoe.com/episode856. In this episode, I’ll discuss the consensus statement published in CHEST on the Treatment of Community-Acquired Pneumonia in immunocompromised patients. The post 856: Treatment of Community-Acquired Pneumonia in immunocompromised patients appeared first on Pharmacy Joe.

Drs. Jamie Rutland and Edward Dominguez discuss RSV in immunocompromised adults due to a variety of conditions, such as cancer, HIV/AIDS and transplantation.

In this episode, Renslow Sherer, MD, discusses managing a first ART failure in the setting of COVID-19, including:Guideline recommendations for resistance testingGuideline recommendations for selecting a new ART regimenData on retained efficacy of NRTIs in second-line regimens in the EARNEST and NADIA studiesConsideration of drug‒drug interactions between ART and COVID-19 treatmentPresenter: Renslow Sherer, MDDirector International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Health Department of Medicine University of Chicago Chicago, Illinois To download the slides: https://bit.ly/3OcqxIE To view the full online program: https://bit.ly/3ZjSFhg

In this episode, Helen Y. Chu, MD, MPH, shares updates on RSV vaccines, including:An overview of vaccine candidates under investigationRecently FDA-approved RSV vaccines for older adultsConsiderations for the next respiratory viral seasonCoadministration of RSV vaccines with other respiratory viral vaccines (eg, influenza, SARS-CoV-2)Target populations for RSV vaccinationRSV prevention in infants with the maternal vaccine and monoclonalFaculty:Helen Y. Chu, MD, MPHAssociate Professor of MedicineDivision of Allergy & Infectious DiseasesUniversity of Washington School of MedicineSeattle, WashingtonLink to full program: https://bit.ly/3nb25xehttps://bit.ly/3nb25xeLink to downloadable slides: https://bit.ly/3TsXym5

Brendan invites Brittany to tell her story to help the audience understand what it means to be immunocompromised. ​​Episode 3 will serve as a human-interest piece and dive into how Brittany coped with her diagnosis, how it changed her life and how the pandemic further complicated her daily living. ​To learn which screenings are appropriate for you, we encourage you to visit the US Preventive Services Task Force. The US Preventive Services Task Force is an independent, volunteer panel of national experts in disease prevention and evidence-based medicine. It works to improve the health of people nationwide by making evidence-based recommendations about clinical preventive services and prolong life.

Jonathan R Latham PhD is a “card-carrying” virologist, the co-founder and Executive Director of the Bioscience Resource Project, and the Editor of Independent Science News. In the first half of today's interview, we discuss several theories of the origin of COVID-19, Fauci's COVID Origin SWAT Team, the significance of RaTG-13 and those Mojang Miners, accelerated viral evolution in immunocompromised hosts, and much more. In the second half, we discuss the many unusual features of the 2014 Ebola Outbreak in West Africa that point to an “unnatural” origin, and the many similarities to the COVID-19 outbreak in Wuhan.

Today, I am blessed to have here with me Marek Doyle. He has spent the last 17 years developing a model of individualized nutrition based on data from over 3,000 individual outcomes, 11,000 test findings, and significant utilization of the scientific literature. Marek is a functional nutritional therapist. In addition to his Academy training course for practitioners and enthusiasts in London, England, Marek offers one-on-one consultations for customers. He holds a Master of Science degree in Personalized Nutrition.  Marek has always greatly respected and fascinated with the human body. He was always driven to nutritional therapy since it is the most fundamental aspect in impacting human biochemistry, and he has spent almost two decades improving his methods. Marek has an MSc in Personalized Nutrition (CNELM/Middlesex Uni), as well as a CertHE in Nutritional Medicine, a Diploma in Allergy and Environmental Therapy (BIAET) and a Diploma in Advanced Nutrition for Optimal Health (GBF/BCMA).  His viewpoint is shaped by everything that can enable him to precisely pinpoint each person's major challenges and predict the result of any given option. It is shaped less by exact answers and more by asking the right questions, which are formed from his personal experiences, combining the mechanical knowledge taken from the scientific literature with the wisdom embedded in traditional healing systems, and by making observations gleaned from working directly with thousands of people. In this episode, Marek speaks about how our bodies can repair themselves so long as you identify the hurdles that prevent it from happening, the flaws of modern weight loss methods, the pros and cons of the ketogenic diet, how the mitochondria work under stress, and things you need to remember before going on a diet. Register your FREE spot for our upcoming 7 day keto challenge. We start January 9th 2023! Sign up here: http://www.ketokampchallenge.com  / / E P I S O D E   S P ON S O R S  Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Upgraded Magnesium & Charge Electrolyte Supplements: http://www.upgradedformulas.com Use KK15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [04:50] The Body's Self-Healing Factor The human body will solve its problems unless an obstacle is blocking the way towards healing. Finding out what that obstacle is is the key to overcoming certain health issues. Once these obstacles are taken away, everything becomes much easier for an individual. These interferences aren't easy to identify or solve, which is why it is up to everybody to identify what they are. [06:28] The Flaws of Popular Weight Loss Methods Many influencers, nutritionists, and dieticians claim that energy balance is the only thing you'll need to lose body fat. Calories in and out are a big deal; however, both can change. This concept is entirely dependent on the body not changing its energy usage all day which makes it very flawed. The calorie concept is deceptive because it works short-term for weight loss but not fat loss. There is a massive difference between these two. [12:00] The Pros and Cons of the Keto Diet Two camps are relevant to this diet. The first one is the people who preach that it's a revolution, and the other is the ones who oppose it due to their belief in its health risks. There is a lot of misconception that still exists about the Keto Diet. One of the most anti-inflammatory interventions available is the Ketogenic Diet. [24:47] What the Mitochondria Does When You Are Stressed There are three different types of stress: Mental and Emotional Stress, Physical Stress, and Chemical Stress. Being under any of these stresses will cause the Mitochondria to generate a ton of oxidative stress. The only thing greater than the human body's capability to handle stress is how far you can push it until it eventually fails. Oxidative stress due to the overworking of the Mitochondria will cause certain problems in the human body. [40:44] Things You Must Consider Before Trying Certain Diets       There are many moving parts in the human body, making a perfect diet unrealistic.       Doing certain diets and fasting is fine; however, you must consider your status and other options first.       Stress, Immunocompromised bodies, your home's condition, and most importantly, your current health condition are some of the few things you need to be mindful of before starting a diet that will massively affect your body.   It's always a matter of identifying the big stressors in your life. AND MUCH MORE! Resources from this episode:  Website: https://www.marekdoyle.com Follow Marek Instagram: https://www.instagram.com/marekdoylenutrition  Twitter: https://twitter.com/marekdoyle  Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a  Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ  Register your FREE spot for our upcoming 7 day keto challenge. We start January 9th 2023! Sign up here: http://www.ketokampchallenge.com  / / E P I S O D E   S P ON S O R S  Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Upgraded Magnesium & Charge Electrolyte Supplements: http://www.upgradedformulas.com Use KK15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Can a shoe design save your life? Neil deGrasse Tyson, Chuck Nice, and Gary O'Reilly explore how engineering can help save the lives– and feet– of thousands with diabetes, with industrial engineer Michael DiTullo and foot and ankle surgeon, Dr. Jason Hanft. NOTE: StarTalk+ Patrons can watch or listen to this entire episode commercial-free here: https://startalkmedia.com/show/feet-of-engineering-with-micheal-ditullo-and-jason-hanft/Photo Credit: Mikael Häggström, M.D., CC0, via Wikimedia Commons

It's the same old script. Mass shooting occurs. Thoughts and prayers fly. Declarations are made. Fingers point. There's something more insidious at play in this nation than just easy access to weapons and ammunition. Our propensity toward gun violence is indicative of a deeper illness. Like many difficult issues, it's never just one thing but a confluence of deadly issues that plague our country. To fight for the “soul of the nation,” one has to first ask whether we ever had one to begin with. Resources EducationWeek: School Shootings This Year: How Many and Where EducationWeek: School Shootings Over Time: Incidents, Injuries, and Deaths EducationWeek: School Shootings in 2021: How Many and Where EducationWeek: School Shootings in 2020: How Many and Where EducationWeek: School Shootings in 2019: How Many and Where EducationWeek: School Shootings in 2018: How Many and Where CNN: How US gun culture stacks up with the world The Violence Project: Explore the shooters, their backgrounds, guns and motivations. World Population Review: Standard of Living by Country | Quality of Life by Country 2022 Forever Wars: What America Does Abroad Is What America Does at Home -- If you like #UNFTR, please leave us a rating and review on Apple Podcasts: unftr.com/rate and follow us on Facebook, Twitter and Instagram at @UNFTRpod. Visit us online at unftr.com. Buy yourself some Unf*cking Coffee at shop.unftr.com. Subscribe to Unf*cking The Republic on Substack at unftr.substack.com to get the essays these episode are framed around sent to your inbox every week. Check out the UNFTR Pod Love playlist on Spotify: spoti.fi/3yzIlUP. Visit our bookshop.org page at bookshop.org/shop/UNFTRpod to find the full UNFTR book list, and find book recommendations from our Unf*ckers at bookshop.org/lists/unf-cker-book-recommendations. Access the UNFTR Musicless feed by following the instructions at unftr.com/accessibility. Unf*cking the Republic is produced by 99 and engineered by Manny Faces Media (mannyfacesmedia.com). Original music is by Tom McGovern (tommcgovern.com). The show is written and hosted by Max and distributed by 99. Podcast art description: Image of the US Congress ripped in the middle revealing white text on a blue background that says, "Unf*cking the Republic." See omnystudio.com/listener for privacy information.

1 in 3 Americans believes the pandemic is over, but waves of illness and hospitalizations continue to cause signifiant disruption and death. Dr. David Dowdy returns to the podcast to talk with Lindsay Smith Rogers about how COVID-19 is impacting both vaccinated and unvaccinated people, why there were so many deaths of vaccinated people from omicron (hints: sheer numbers and outsize impacts on older and immunocompromised individuals), and a look at where we are now and what we can expect in the coming months.  

People are returning to in-person work, mask and vaccine mandates have come down nationwide, but U.S. health officials are anticipating a new rise in COVID-19 cases because of the B.A. 2 variant. And many people with disabilities, or who are immunocompromised, are feeling vulnerable and left behind in this rush to reopen. Plus, Ukraine is losing patience with Israel. And, a moment of joy from the cherry blossom-filled US capital. Guests: Beatrice Adler-Bolton, a disability justice advocate and writer based in New York and Axios' Barak Ravid. Credits: Axios Today is produced by Niala Boodhoo, Sara Kehaulani Goo, Julia Redpath, Alexandra Botti, Nuria Marquez Martinez, Sabeena Singhani, Lydia McMullen-Laird, and Alex Sugiura. Music is composed by Evan Viola. You can reach us at podcasts@axios.com. You can text questions, comments and story ideas to Niala as a text or voice memo to 202-918-4893. Learn more about your ad choices. Visit megaphone.fm/adchoices

According to the most recent guidance from the CDC, most of the country no longer needs to mask up in public But those loosened restrictions don't apply to at least 7 million people nationwide who are immunocompromised. Their weakened immune systems put them at much higher risk for severe illness and death from exposure to COVID.With elected officials advocating a so-called "return to normal," what does the present and future hold for the immunocompromised? What can we do to protect the most vulnerable?Want to support 1A? Give to your local public radio station and subscribe to this podcast. Have questions? Find us on Twitter @1A.

Vaccine advisers to the CDC voted unanimously to recommend an extra dose of the Covid-19 vaccine for some immunocompromised people. The FDA had already authorized a third dose in certain patients who are likely to have had a poor response to two doses of either Pfizer or Moderna’s vaccine. Dr. Peter Hotez is the co-director for the Center for Vaccine Development at Texas Children’s Hospital. He joins AC360 to discuss the CDC’s recommendation. Plus, John Cohen, the Homeland Security Intelligence chief told CNN online extremist rhetoric is strikingly similar to the buildup to the January 6 attack on the U.S. Capitol. Republican Rep. Adam Kinzinger is a member of the bipartisan House select committee that’s investigating the insurrection. He tells Anderson Cooper conspiracy theories and false narratives can grow into action and “it’s a real concern.” Airdate: Friday August 13, 2021 Guests: Dr. Peter Hotez Rep. Adam KinzingerTo learn more about how CNN protects listener privacy, visit cnn.com/privacy