POPULARITY
3 episodes with s2213
3 episodes with s2213
2 episodes with s2213
2 episodes with s2213
2 episodes with s2213
2 episodes with s2213
2 episodes with s2213
4 episodes with s2213
3 episodes with s2213
Send us a textAzithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial.Lowe J, Gillespie D, Aboklaish A, Lau TMM, Consoli C, Babu M, Goddard M, Hood K, Klein N, Thomas-Jones E, Turner M, Hubbard M, Marchesi J, Berrington J, Kotecha S.Lancet Respir Med. 2024 Aug;12(8):608-618. doi: 10.1016/S2213-2600(24)00079-1. Epub 2024 Apr 25.PMID: 38679042 Free article. Clinical Trial. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
Neste episódio discutimos a nova classificação de Obesidade (Pré-Clínica e Clínica) proposta no artigo recém publicado no Lancet em janeiro deste ano (2025).Referência bibliográfica: Rubino F, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025 Jan 9:S2213-8587(24)00316-4. doi: 10.1016/S2213-8587(24)00316-4. PMID: 39824205.
Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks. This month we're discussing: Tricuspid Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation: 1-Year Outcomes From the TRILUMINATE Randomized Cohort DOI: https://doi.org/10.1016/j.jacc.2024.10.086 Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation: The Tri.Fr Randomized Clinical Trial DOI: https://doi.org/10.1001/jama.2024.21189 Alternative LDL Cholesterol–Lowering Strategy vs High-Intensity Statins in Atherosclerotic Cardiovascular Disease - A Systematic Review and Individual Patient Data Meta-Analysis DOI: https://doi.org/10.1001/jamacardio.2024.3911 Treatment regimens and glycaemic outcomes in more than 100 000 children with type 1 diabetes (2013–22): a longitudinal analysis of data from paediatric diabetes registries DOI: https://doi.org/10.1016/S2213-8587(24)00279-1 Scientific team: Ricardo Ladeiras Lopes, Mário Santos and João Sérgio Neves Discover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! https://linktr.ee/medicalportfolioapp
We are back with more exciting IDWeek 2024 content. In this episode, Breakpoints hostesses Drs. Erin McCreary, Julie Ann Justo, Jeannette Bouchard, and Megan Klatt highlight more of our favorite sessions and posters at IDWeek, this episode is a must listen if you are an IDWeek nerd like us! References: Perret et al. Application of OpenAI GPT-4 for the retrospective detection of catheter-associated urinary tract infections in a fictitious and curated patient data set. 10.1017/ice.2023.189 Wiemken et al. Assisting the infection preventionist: Use of artificial intelligence for health care–associated infection surveillance. 10.1016/j.ajic.2024.02.007 Leekha et al. Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study. 10.1136/bmjqs-2023-016831 Diekema et al. Are Contact Precautions "Essential" for the Prevention of Healthcare-associated Methicillin-Resistant Staphylococcus aureus? 10.1093/cid/ciad571 Martin et al. Contact precautions for MRSA and VRE: where are we now? A survey of the Society for Healthcare Epidemiology of America Research Network. 10.1017/ash.2024.350 Browne et al. Investigating the effect of enhanced cleaning and disinfection of shared medical equipment on health-care-associated infections in Australia (CLEEN): a stepped-wedge, cluster randomised, controlled trial. 10.1016/S1473-3099(24)00399-2 Protect trial: Decolonization in Nursing Homes to Prevent Infection and Hospitalization. 10.1056/NEJMoa2215254 Aldardeer et al. Early Versus Late Antipseudomonal β-Lactam Antibiotic Dose Adjustment in Critically Ill Sepsis Patients With Acute Kidney Injury: A Prospective Observational Cohort Study. 10.1093/ofid/ofae059 Schmiemann et al. Effects of a multimodal intervention in primary care to reduce second line antibiotic prescriptions for urinary tract infections in women: parallel, cluster randomised, controlled trial. 10.1136/bmj-2023-076305 Vernacchio et al. Improving Short Course Treatment of Pediatric Infections: A Randomized Quality Improvement Trial. 10.1542/peds.2023-063691 Advani et al. Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria. 10.1001/jamanetworkopen.2024.2283 Saif et al. Clinical decision support for gastrointestinal panel testing. 10.1017/ash.2024.15 Bekker et al. Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women. 10.1056/NEJMoa2407001 Montini et al. Short Oral Antibiotic Therapy for Pediatric Febrile Urinary Tract Infections: A Randomized Trial. 10.1542/peds.2023-062598 Nielsen et al. Oral versus intravenous empirical antibiotics in children and adolescents with uncomplicated bone and joint infections: a nationwide, randomised, controlled, non-inferiority trial in Denmark. 10.1016/S2352-4642(24)00133-0 Kaasch et al. Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial. 10.1016/S1473-3099(23)00756-9 AMIKINHAL: Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia. 10.1056/NEJMoa2310307 PROPHY-VAP: Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial. 10.1016/S2213-2600(23)00471-X AVENIR: Azithromycin to Reduce Mortality — An Adaptive Cluster-Randomized Trial. 10.1056/NEJMoa2312093 Thomas et al. Comparison of Two High-Dose Versus Two Standard-Dose Influenza Vaccines in Adult Allogeneic Hematopoietic Cell Transplant Recipients. 10.1093/cid/ciad458 Schuster et al. The Durability of Antibody Responses of Two Doses of High-Dose Relative to Two Doses of Standard-Dose Inactivated Influenza Vaccine in Pediatric Hematopoietic Cell Transplant Recipients: A Multi-Center Randomized Controlled Trial. 10.1093/cid/ciad534 Mahadeo et al. Tabelecleucel for allogeneic haematopoietic stem-cell or solid organ transplant recipients with Epstein-Barr virus-positive post-transplant lymphoproliferative disease after failure of rituximab or rituximab and chemotherapy (ALLELE): a phase 3, multicentre, open-label trial. 10.1016/S1470-2045(23)00649-6 Khoury et al. Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant. 10.1016/j.ajt.2024.04.009 Spec et al. MSG-15: Super-Bioavailability Itraconazole Versus Conventional Itraconazole in the Treatment of Endemic Mycoses—A Multicenter, Open-Label, Randomized Comparative Trial. 10.1093/ofid/ofae010
In this episode of Hot Topics, Dr. Nicholas Morris interviews Claire Dahyot-Fizelier, M.D, Ph.D., a professor of anesthesia and intensive care at the University of Poitiers, to explore the groundbreaking PROPHY-VAP trial published in The Lancet Respiratory Medicine. This landmark study investigates the impact of single-dose ceftriaxone prophylaxis on ventilator-associated pneumonia (VAP) in acute brain injury patients. Dr. Dahyot-Fizelier discusses the rationale behind the study, key findings and the broader implications for ICU practices. Tune in to discover how this trial could reshape approaches to infection prevention and improve patient outcomes in neurocritical care. Show notes: https://doi.org/10.1016/S2213-2600(23)00471-X Dahyot-Fizelier C, Lasocki S, Kerforne T, Perrigault PF, Geeraerts T, Asehnoune K, Cinotti R, Launey Y, Cottenceau V, Laffon M, Gaillard T, Boisson M, Aleyrat C, Frasca D, Mimoz O, on behalf of the PROPHY-VAP Study Group and the ATLANREA Study Group. Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial. The Lancet Respiratory Medicine. 2024 May 1;12(5):375-85.
In this Hot Take episode, Johanna and Sonya venture beyond the outdated "iron curtain" myth of Menopausal Hormone Therapy after age 60, revealing a new Australian research paper that could transform women's menopause care and longevity.We dive into the confusion that often surrounds vaginal estrogen because of misleading warnings on packaging. The exaggerated risks deter many from reaping the health benefits these products offer and many doctors from prescribing it. And we chat about the anticipated "So Hot Right Now" event at the Sydney Opera House in early 2925. With renowned voices like Dr's Louise Newson, Vonda Wright and Kelly Casperson sharing their expertise with an Australian audience, this event promises to continue to elevate the vibrant dialogue on menopause. Links:Research PaperTaylor S, Davis SR. Is it time to revisit the recommendations for initiation of menopausal hormone therapy? Lancet Diabetes Endocrinol. 2024 Oct 14:S2213-8587(24)00270-5. doi: 10.1016/S2213-8587(24)00270-5. Epub ahead of print. PMID: 39419045.You Are Not Broken Podcast Episode with Dr Kelly Casperson and Dr Corinne Menn- AppleUnboxing Menopause CampaignAustralian Journal of General Practice: Volume 53, Issue 5, May 2024 "Safety of vaginal oestrogens for genitourinary symptoms in women with breast cancer" "Vaginal estrogen use for genitourinary symptoms in women with a history of uterine, cervical, or ovarian carcinoma"So Hot Right Now event ticketsThank you for listening to my show! Join the conversation on Instagram
In this episode of the You're Not Broken podcast, Dr. Kelly Casperson and Dr. Corinne Menn discuss the recent paper by Sasha Taylor and Susan Davis that revisits the recommendations for initiating menopausal hormone therapy. They explore the arbitrary nature of age cutoffs for hormone therapy, the timing hypothesis, and the implications of the Women's Health Initiative data. The conversation emphasizes the importance of understanding the risks and benefits of hormone therapy, particularly for women over 60, and addresses common misconceptions surrounding hormone therapy and its effects on bone health and dementia. The episode concludes with a call to action for women to advocate for their health and seek appropriate hormone therapy. Takeaways Millions of women feel they have been overlooked in hormone therapy discussions. The age cutoffs for hormone therapy initiation are arbitrary and not based on solid evidence. The timing hypothesis suggests that starting hormone therapy earlier can lead to better health outcomes. The Women's Health Initiative data is often misinterpreted and does not reflect the current understanding of hormone therapy. Hormone therapy can provide long-term benefits for bone health and reduce the risk of osteoporosis. Many women experience symptoms beyond hot flashes that can persist for years after menopause. The risks associated with hormone therapy are often overstated and misunderstood. Women over 60 should not be denied hormone therapy based solely on age or years since menopause. Dementia risk associated with hormone therapy is not as significant as previously thought, especially with proper medication choices. Women need to advocate for their health and seek out hormone therapy options that are safe and effective. Taylor S, Davis SR. Is it time to revisit the recommendations for initiation of menopausal hormone therapy? Lancet Diabetes Endocrinol. 2024 Oct 14:S2213-8587(24)00270-5. doi: 10.1016/S2213-8587(24)00270-5. Epub ahead of print. PMID: 39419045. Thanks to our sponsor Midi Women's Health. Designed by midlife experts, delivered by experienced clinicians, covered by insurance. Midi is the first virtual care clinic made exclusively for women 40+. Evidence-based treatments. Personalized midlife care. https://www.joinmidi.com To learn more about Via vaginal moisturizer from Solv Wellness, visit via4her.com for 30% off your first purchase of any product, automatically applied at checkout. For an additional $5 off, use coupon code DRKELLY5. Order my book "You Are Not Broken: Stop "Should-ing" All Over You Sex Life" Listen to my Tedx Talk: Why we need adult sex ed Take my Adult Sex Ed Master Class: Join my membership to get these episodes ASAP, a private facebook group to discuss and my private accountability group for your health, hormones and life support! www.kellycaspersonmd.com/membership Interested in my sexual health and hormone clinic? Starts January 2025. Learn more about your ad choices. Visit megaphone.fm/adchoices
Send us a textLung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial.Vento G, Ventura ML, Pastorino R, van Kaam AH, Carnielli V, Cools F, Dani C, Mosca F, Polglase G, Tagliabue P, Boni L, Cota F, Tana M, Tirone C, Aurilia C, Lio A, Costa S, D'Andrea V, Lucente M, Nigro G, Giordano L, Roma V, Villani PE, Fusco FP, Fasolato V, Colnaghi MR, Matassa PG, Vendettuoli V, Poggi C, Del Vecchio A, Petrillo F, Betta P, Mattia C, Garani G, Solinas A, Gitto E, Salvo V, Gargano G, Balestri E, Sandri F, Mescoli G, Martinelli S, Ilardi L, Ciarmoli E, Di Fabio S, Maranella E, Grassia C, Ausanio G, Rossi V, Motta A, Tina LG, Maiolo K, Nobile S, Messner H, Staffler A, Ferrero F, Stasi I, Pieragostini L, Mondello I, Haass C, Consigli C, Vedovato S, Grison A, Maffei G, Presta G, Perniola R, Vitaliti M, Re MP, De Curtis M, Cardilli V, Lago P, Tormena F, Orfeo L, Gizzi C, Massenzi L, Gazzolo D, Strozzi MCM, Bottino R, Pontiggia F, Berardi A, Guidotti I, Cacace C, Meli V, Quartulli L, Scorrano A, Casati A, Grappone L, Pillow JJ.Lancet Respir Med. 2021 Feb;9(2):159-166. doi: 10.1016/S2213-2600(20)30179-X. Epub 2020 Jul 17.PMID: 32687801 Clinical Trial. Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial.Gallini F, De Rose DU, Iuliano R, Romeo DM, Tana M, Paladini A, Fusco FP, Nobile S, Cota F, Tirone C, Aurilia C, Lio A, Esposito A, Costa S, D'Andrea V, Ventura ML, Carnielli V, Dani C, Mosca F, Fumagalli M, Scarpelli G, Giordano L, Fasolato V, Petrillo F, Betta P, Solinas A, Gitto E, Gargano G, Mescoli G, Martinelli S, Di Fabio S, Bernardo I, Tina LG, Staffler A, Stasi I, Mondello I, Scapillati E, Vedovato S, Maffei G, Bove A, Vitaliti M, Terrin G, Lago P, Gizzi C, Strozzi C, Villani PE, Berardi A, Cacace C, Bracaglia G, Pascucci E, Cools F, Pillow JJ, Polglase G, Pastorino R, van Kaam AH, Mercuri E, Orfeo L, Vento G; IN-REC-SUR-E Study Group; Malguzzi S, Rigotti C, Cecchi A, Nigro G, Costabile CD, Roma E, Sindico P, Venafra R, Mattia C, Conversano M, Ballardini E, Manganaro A, Balestri E, Gallo C, Catenazzi P, Astori MG, Maranella E, Grassia C, Maiolo K, Castellano D, Massenzi L, Chiodin E, Gallina MR, Consigli C, Sorrentino E, Bonato S, Mancini M, Perniola R, Giannuzzo S, Tranchina E, Cardilli V, Dito L, Regoli D, Tormena F, Battajon N, Arena R, Allais B, Guidotti I, Roversi F, Meli V, Tulino V, Casati A.JAMA Netw Open. 2024 Sep 3;7(9):e2435347. doi: 10.1001/jamanetworkopen.2024.35347.PMID: 39320892 Free PMC article. Clinical Trial.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks. This month we're discussing: Improving Cardiac Rehabilitation Adherence in Patients With Lower Socioeconomic Status DOI:10.1001/jamainternmed.2024.3338 Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study DOI:10.1161/CIRCULATIONAHA.124.069340 Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: a SMART-C collaborative meta-analysis of randomised controlled trials DOI.org/10.1016/S2213-8587(24)00155-4 Scientific team: Ricardo Ladeiras Lopes, Mário Santos and João Sérgio Neves Discover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! https://linktr.ee/medicalportfolioapp
Welcome to the final episode of our 3-part series “Men's Health Table Talk, Nutrition and Cancer related Andropause” by UCC student Dietitians Daniel Coakley and Emma Barrett. So far on this series, we have spoken with RD Katie Johnston who provided us with some very insightful and evidence-based information about the nutritional consequences oftentimes faced by male cancer survivors as a result of their cancer treatment. We also chatted about the changes that occur in body composition along with the importance of evidence-based information when it comes to supplements and potential dietary changes. In our second episode, we spoke with coach and personal trainer Aidan Hunter, who provided us with a very personal account of his own journey with cancer having faced testicular cancer twice in his mid 20's. Aidan's honest and candid discussion was a powerful reminder of how important early detection and screening is when it comes to cancer prevention. For our final episode, we will explore evidence based recommendations to reduce cancer recurrence for male cancer survivors. These guidelines can also be applied to people listening who would like to reduce their risk of cancer. In the second half of this episode, we will be chatting with Health Promotion Officer Shirley O'Shea about her expertise in public health and working with individuals with cancer. Shirly's main role is centered around physical activity promotion with a special interest in exercise oncology. We explore the current services and support available for male cancer survivors going through or who have been through treatment. We also discuss strategies to encourage more men to access healthcare and health-related services, aiming to break the stigma surrounding men speaking openly about their health. Links to some useful resources and topics discussed in today's episode: World Cancer Research Fund: https://www.wcrf.org/ International Agency for Research on Cancer: https://www.iarc.who.int/ HSE Healthy Eating Guidelines https://www.hse.ie/healthyeatingguidelines/ HSE Healthy Eating Active Living https://www2.hse.ie/living-well/. Get Ireland Walking https://www.getirelandwalking.ie/ Drink Aware: https://www.drinkaware.ie/ The Irish Cancer Society: https://www.cancer.ie/ Cork Cancer Support House: https://corkcancersupport.ie/ Men Against Cancer: https://macprostatecancersupport.ie/men-against-cancer/ Research papers mentioned in today's episode: Recent review on common symptoms and conditions related to endocrine disorders among survivors of adult-onset cancer: Link-Rachner CS, Göbel A, Jaschke NP, Rachner TD. Endocrine health in survivors of adult-onset cancer. Lancet Diabetes Endocrinol. 2024 May;12(5):350-364. doi: 10.1016/S2213-8587(24)00088-3. Epub 2024 Apr 8. PMID: 38604215. Role of the Mediterranean Diet and Cancer: Monllor-Tormos A, García-Vigara A, Morgan O, García-Pérez MÁ, Mendoza N, Tarín JJ, Cano A. Mediterranean diet for cancer prevention and survivorship. Maturitas. 2023 Dec;178:107841. doi: 10.1016/j.maturitas.2023.107841. Epub 2023 Aug 24. PMID: 37660598
Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks. This month we're discussing: Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction DOI: 10.1056/NEJMoa2401479 Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial DOI: 10.1016/S0140-6736(24)00413-6 Familial aggregation and heritability of childhood-onset and adult-onset type 1 diabetes: a Swedish register-based cohort study. DOI:10.1016/S2213-8587(24)00068-8 Dapagliflozin in patients with heart failure and previous myocardial infarction: A participant-level pooled analysis of DAPA-HF and DELIVER DOI: 10.1002/ejhf.3184 Scientific team: Ricardo Ladeiras Lopes, Mário Santos and João Sérgio Neves Discover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! https://linktr.ee/medicalportfolioapp
Statins and diabetes, AAD in patients with heart disease, tricuspid valve interventions, and an ACC preview are the topics John Mandrola, MD, discusses in this week's podcast.This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Statins and Diabetes Meta-analysis in Lancet-Diabetes https://doi.org/10.1016/S2213-8587(24)00040-8 Editorial https://doi.org/10.1016/S2213-8587(24)00059-7 NEJM Paper on Gene Variants and DM https://www.nejm.org/doi/full/10.1056/nejmoa1604304 JAMA Paper on Gene Variants and DM https://jamanetwork.com/journals/jama/fullarticle/2565289 II. Anti-arrhythmic Drugs in Patients With Serious Heart Disease UPenn Paper on AADs for PVC Suppression https://doi.org/10.1016/j.jacep.2024.01.021 Three Questions for Evidence-Based Cardiac EP https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381 CAST trial https://www.nejm.org/doi/full/10.1056/NEJM199103213241201 III. Tricuspid Valve Interventions FDA Clears TriClip for Tricuspid Regurgitation https://www.medscape.com/viewarticle/fda-clears-triclip-tricuspid-regurgitation-2024a100068o FDA Panel in Favor of TriClip for Tricuspid Regurgitation https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n Slides for Trisend II TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525 IV. ACC Preview Mandrola's Three Trials to Look for at the 2024 American College of Cardiology Scientific Sessions https://www.medscape.com/viewarticle/1000613 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net
Contributor: Ricky Dhaliwal MD Educational Pearls: Primary adrenal insufficiency (most common risk factor for adrenal crises) An autoimmune condition commonly known as Addison's Disease Defects in the cells of the adrenal glomerulosa and fasciculata result in deficient glucocorticoids and mineralocorticoids Mineralocorticoid deficiency leads to hyponatremia and hypovolemia Lack of aldosterone downregulates Endothelial Sodium Channels (ENaCs) at the renal tubules Water follows sodium and generates a hypovolemic state Glucocorticoid deficiency contributes further to hypotension and hyponatremia Decreased vascular responsiveness to angiotensin II Increased secretion of vasopressin (ADH) from the posterior pituitary An adrenal crisis is defined as a sudden worsening of adrenal insufficiency Presents with non-specific symptoms including nausea, vomiting, fatigue, confusion, and fevers Fevers may be the result of underlying infection Work-up in the ED includes labs looking for infection and adding cortisol + ACTH levels Emergent treatment is required 100 mg hydrocortisone bolus followed by 50 mg every 6 hours Immediate IV fluid repletion with 1L normal saline The most common cause of an adrenal crisis is an acute infection in patients with baseline adrenal insufficiency Often due to a gastrointestinal infection References 1. Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. Lancet Diabetes Endocrinol. 2015;3(3):216-226. doi:10.1016/S2213-8587(14)70142-1 2. Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(2):364-389. doi:10.1210/jc.2015-1710 3. Cronin CC, Callaghan N, Kearney PJ, Murnaghan DJ, Shanahan F. Addison disease in patients treated with glucocorticoid therapy. Arch Intern Med. 1997;157(4):456-458. 4. Feldman RD, Gros R. Vascular effects of aldosterone: sorting out the receptors and the ligands. Clin Exp Pharmacol Physiol. 2013;40(12):916-921. doi:10.1111/1440-1681.12157 5. Hahner S, Loeffler M, Bleicken B, et al. Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies. Eur J Endocrinol. 2010;162(3):597-602. doi:10.1530/EJE-09-0884 Summarized by Jorge Chalit, OMSII | Edited by Meg Joyce & Jorge Chalit
Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks. This month we're discussing: Aspirin and Cardiovascular Risk in Individuals With Elevated Lipoprotein(a): The Multi‐Ethnic Study of Atherosclerosis DOI: https://doi.org/10.1161/JAHA.123.033562 Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy. The ARCADIA Randomized Clinical Trial DOI: https://doi.org/10.1001/jama.2023.27188 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study DOI: https://doi.org/10.1016/S2213-8587(23)00385-6 Scientific team: Ricardo Ladeiras Lopes, Mário Santos and João Sérgio Neves Discover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! https://linktr.ee/medicalportfolioapp
Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks. This month we're discussing: Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure DOI: https://doi.org/10.1056/NEJMoa2304542 Optimization of Evidence-Based Heart Failure Medications After an Acute Heart Failure Admission: A Secondary Analysis of the STRONG-HF Randomized Clinical Trial https://doi.org/10.1001/jamacardio.2023.4553 Impact of Remission from Type 2 Diabetes on Long-term Health Outcomes: Findings from the Look AHEAD StudyDOI: https://doi.org/10.1007/s00125-023-06048-6 Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial DOI: https://doi.org/10.1016/S2213-8587(23)00316-9 Scientific team: Ricardo Ladeiras Lopes, Mário Santos and João Sérgio Neves Discover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! https://linktr.ee/medicalportfolioapp
Welcome back to the next instalment of respiratory GURU, this time we delve into two RCTs investigating rescue therapy for patients with CTD ILD. The EVER ILD study looks at MMF vs MMF plus rituximab, and the RECITAL study looks at rituximab vs cyclophosphamide. 2 very useful studies and I was thrilled to be joined by two national experts in the field, Dr Anjali Crawshaw and Dr Emma Derrett-Smith. Hopefully, this will make you feel more well-prepared for ILD MDTs, and give you a real insight into how these two experts view the recent literature in the context of their day-to-day practice. Here are the pubmed links for the two papers, the INBUILD study which we discuss briefly, and the American College of Rheumatology guidelines, which apparently is where most of the guidance we need regarding CTD ILD (for now) sits. Enjoy listening, thank you for being patient with the podcast releases whilst I birthed and raised my second child, and fingers crossed no more career interruptions!!Mankikian J et al. Rituximab and mycophenolate mofetil combination in patients with interstitial lung disease (EVER-ILD): a double-blind, randomised, placebo-controlled trial. Eur Respir J. 2023 Jun 8;61(6):2202071. doi: 10.1183/13993003.02071-2022. PMID: 37230499.Maher TM et al. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial. Lancet Respir Med. 2023 Jan;11(1):45-54. doi: 10.1016/S2213-2600(22)00359-9. Epub 2022 Nov 11. PMID: 36375479.interstitial-lung-disease-guideline-summary-treatment-2023.pdf (contentstack.io)Support the show
Welcome to the new series Normless Performance! In the first episode we are joined by returning guest Drew Harrisberg and Sam Scott. Drew shared his story of diagnosis with type 1 diabetes in episode 22 of the podcast, you can listen to it here.Sam is an exercise physiologist with clinical and applied research experience in the field of obesity, diabetes, and continuous glucose monitoring technology. His academic work has been primarily dedicated to devising innovative strategies—incorporating nutrition, behavioral modifications, and technology—to empower individuals living with type 1 diabetes in effectively managing their glucose levels during physical exercise. Moreover, Sam has cultivated a close working relationship with professional athletes who grapple with type 1 diabetes, serving as the Head of Research for Team Novo Nordisk for a period spanning over four years. During this time, he followed the athletes during races and training to explore the demands of professional cycling on these athletes. More recently, Sam co-founded enhance-d, which aims to revolutionize the utilization of data derived from diabetes technology and lifestyle wearables. Their mission is to streamline and simplify the process of harnessing this data to optimize glucose management during exercise.________________ReferencesDOI: 10.1002/edm2.180 - Scott et al. (2020). Use and perception of telemedicine in people with type 1 diabetes during the COVID-19 pandemic - results of a global survey.DOI: 10.3390/nu11051022 - Scott et al. (2020). Carbohydrate Restriction in Type 1 Diabetes: A Realistic Therapy for Improved Glycaemic Control and Athletic Performance?DOI: 10.1016/S2213-8587(21)00054-1 - Scott et al. (2021). Post exercise recovery for the endurance athlete with type 1 diabetes: a consensus statement.DOI: 10.3390/nu11123017 - Scott et al. (2019). Carbohydrate Intake in the Context of Exercise in People living with Type 1 Diabetes.DOI: 10.2337/dc11-1844 - Yardley et al. (2012). Effects of Performing Resistance Exercise Before Versus After Aerobic Exercise on Glycemia in Type 1 Diabetes._______________Enhance-d diabetes self-management softwareWebsite: www.enhance-d.comInstagram: @enhance_d_officialSam's LinksTwitter: @SamNathanScottLinkedInResearch gateGoogle scholarDrew's linksInstagram: @drews.daily.doseDrew's Daily Dose: www.drewsdailydose.com_______________Follow us on social media!Instagram: @normlesspodcast YouTube: www.youtube.com/@normlessFacebook: www.facebook.com/normlesspodcast/ LinkedIn: https://www.linkedin.com/company/norm...TikTok: https://www.tiktok.com/@normlesspodcastWebsite: normlesspodcast.simplecast.com________________Hayden Kelly, ESSAM, AES, AEP, MHPSHost of the NORMLESS podcastConnect with me on Instagram, Twitter, Facebook and LinkedIn ________________Want to support the show?The best way to show your support is by providing a review on the Apple Podcast app, Spotify or via our facebook page.You can also stay in the loop with the latest podcast updates, news and information by subscribing to our mailing list.
Le Dr Florent Baudin, qui est MCU-PH de réanimation pédiatrique aux Hospices Civils de Lyon, nous parle des particularités du SDRA chez l'enfant et/ou le nouveau-né. Aucun conflit d'intérêt n'est déclaré. Sommaire : Quelles sont les particularités de la définition du SDRA chez l'enfant et/ou le nouveau-né ? Quelles en sont les principales causes ? Quelles sont les modalités ventilatoires conventionnelles utilisées chez l'enfant et/ou le nouveau-né ? Quelles sont les thérapies adjuvantes couramment utilisées chez l'enfant et/ou le nouveau-né ? Bibliographie : Emeriaud G, López-Fernández YM, Iyer NP et al, Pediatr Crit Care Med. 2023 Feb 1;24(2):143-168. doi: 10.1097/PCC.0000000000003147. Khemani RG, Smith L, Lopez-Fernandez YM et al,Lancet Respir Med. 2019 Feb;7(2):115-128. doi: 10.1016/S2213-2600(18)30344-8. De Luca D, van Kaam AH, Tingay DG et al, Lancet Respir Med. 2017 Aug;5(8):657-666. doi: 10.1016/S2213-2600(17)30214-X.
In this World Shared Practice Forum podcast, Drs. Suchitra Ranjit and Luregn Schlapbach, discuss a framework to provide individualized hemodynamic support for pediatric patients with septic shock, especially those in lower and middle-income countries. The authors discuss considerations described in their expert group's recent article, including how to administer and assess the response of various therapies such as fluids, inotropes, and pressors. LEARNING OBJECTIVES By the end of this podcast, learners will be able to: - Describe the challenges to the early recognition of septic shock in children through a global lens - Introduce the concepts of flow, pressure, and filling in the context of septic shock and their clinical application - Discuss the individualized approach to fluid use in the treatment of septic shock in pediatric patients - Review the literature surrounding the use of fluids in pediatrics and adults AUTHORS Suchitra Ranjit, MD Chief, Pediatric Intensive Care Unit Apollo Children's Hospital, Chennai, India Luregn Schlapbach, Prof, MD, PhD, FCICM Head, Department of Intensive Care and Neonatology University Children`s Hospital Zurich, Switzerland DATES: Initial publication: August 22, 2023 CITATION: Ranjit S, Schlapbach LJ, O'Hara JE, Wolbrink TA. Individualized Hemodynamic Support for Pediatric Patients with Septic Shock. 08/2023. OPENPediatrics. Online Podcast. YT: https://youtu.be/AK6Uz_hZ_SY SC: https://soundcloud.com/openpediatrics/individualized-hemodynamic-support-for-pediatric-patients-with-septic-shock. ARTICLED REFERENCED: - Ranjit S, Kissoon N, Argent A, et al. Haemodynamic support for paediatric septic shock: a global perspective. Lancet Child Adolesc Health. 2023;7(8):588-598. doi:10.1016/S2352-4642(23)00103-7 - Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223-230. doi:10.1016/S2213-2600(18)30063-8 (1:15) - Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011;364(26):2483-2495. doi:10.1056/NEJMoa1101549 (4:58) - Gu W, Deng X, Lee M, et al. Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids. Nat Med. 2021;27(1):115-124. doi:10.1038/s41591-020-1105-z (14:02) - Meyhoff TS, Hjortrup PB, Wetterslev J, et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med. 2022;386(26):2459-2470. doi:10.1056/NEJMoa2202707 (24:50) - National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023;388(6):499-510. doi:10.1056/NEJMoa2212663 (24:52) Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
Quelle est l'importance de la prise en charge des maladies auto-immunes systémiques par les rhumatologues ? Quel article portant sur le lupus systémique a marqué l'année 2022 ? Quel article portant sur le syndrome de Sjögren a marqué 2022 ? Quel article portant sur la sclérodermie a marqué 2022 ? Quelle conclusion apporter sur ces trois articles ? Le Pr Xavier Mariette, rhumatologue dans le service de Rhumatologie à l'hôpital du Kremlin-Bicêtre (Université Paris Saclay), et médecin coordonnateur du Centre National de Référence des Maladies Auto-Immunes Systémiques Rares constitutif pour le syndrome de Sjögren, répond à vos questions. Invité : Pr Xavier Mariette – Hôpital Bicêtre – Le Kremlin-Bicêtre https://www.aphp.fr/service/service-04-010 https://maladiesrares-paris-saclay.aphp.fr/centre-de-reference-des-maladies-auto-immunes-systemiques-rares/ Le Pr Mariette déclare des liens d'intérêts avec les laboratoires Astra Zenaca, BMS, Galapagos, GSK Novartis, Pfizer. L'équipe : Comité scientifique : Pr Jérémie Sellam, Pr Thao Pham, Dr Catherine Beauvais, Dr Véronique Gaud-Listrat, Dr Céline Vidal, Dr Sophie Hecquet Animation : Pyramidale Communication Production : Pyramidale Communication Soutien institutionnel : Pfizer Crédits : Pyramidale Communication, Sonacom Articles cités : 1. Vital EM, Merrill JT, Morand EF, Furie RA, Bruce IN, Tanaka Y, Manzi S, Kalunian KC, Kalyani RN, Streicher K, Abreu G, Tummala R. Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials. Ann Rheum Dis. 2022 Jul;81(7):951-961. doi: 10.1136/annrheumdis-2021-221425. Epub 2022 Mar 25. PMID: 35338035; PMCID: PMC9213795. 2. Mariette X, Barone F, Baldini C, Bootsma H, Clark KL, De Vita S, Gardner DH, Henderson RB, Herdman M, Lerang K, Mistry P, Punwaney R, Seror R, Stone J, van Daele P, van Maurik A, Wisniacki N, Roth DA, Tak PP. A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren's syndrome. JCI Insight. 2022 Dec 8;7(23):e163030. doi: 10.1172/jci.insight.163030. PMID: 36477362. 3. Maher TM, Tudor VA, Saunders P, Gibbons MA, Fletcher SV, Denton CP, Hoyles RK, Parfrey H, Renzoni EA, Kokosi M, Wells AU, Ashby D, Szigeti M, Molyneaux PL; RECITAL Investigators. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial. Lancet Respir Med. 2022 Nov 11:S2213-2600(22)00359-9. doi: 10.1016/S2213-2600(22)00359-9. Epub ahead of print. PMID: 36375479
Lege Sjur Even Aunmo er opptatt av å følge med på forskning. I denne episoden forteller han om problemene med å leve av planter. Planter har nemlig forsvarsmekanismer mot å bli spist. De kan dessuten stjele mineraler, trigge immunsystemet, tilføre tungmetall og gi næring til kreft. Selv foretrekker han et kosthold bestående utelukkende av animalske produkter. Han synes det er beklagelig at rådene har blitt politiske gjennom at de har tatt inn klimasaken, fremfor at de er en mest mulig sann fremstilling av hva ulike typer mat gjør med kroppen. Aunmo legger frem forskningsevidens som peker i motsatt retning av kostholdsrådene norske myndigheter har lagt frem nylig. Han har mange suksesshistorier fra pasienter med autoimmune sykdommer, diabetes og andre sykdommer, som har blitt friske etter at de sluttet å spise bestemte typer planter, produkter fra planter eller utelukket dem helt fra kosten.Sjur Even Aunmo: • youtube.com • facebook.comGrønnsaker uten noen kjent form for gluten: • hodekål, blomkål, brokkoli, paprika, rødbeter, bladbete, squash, potet, søtpotet, gulrøtter, gresskar, romano-salat, indisk bladsennep, spinat, grønnkål • Obs: Selv om disse plantene ikke inneholder gluten, finnes det andre stoffer i dem som er uheldige. Paprika, for eksempel, hører til søtvier-familien, sammen med potet og tobakk. De forsvarer seg mot mennesker, dyr og insekter med lektiner og solanin. Spinat inneholder mye oksalat som stjeler kalsium fra kroppen. Det finnes igjen i nyrestener og mistenkes for å stimulere brystkreft. Grønnsaker inneholder druesukker, som er et viktig næringsstoff for kreft. Grønnsaker som vokser over bakken inneholder ofte mindre sukker enn de som vokser under bakken. De minst usunne grønnsakene på listen synes å være hodekål, blomkål og brokkoli, på tross av at disse danner goitrin, et stoff som motvirker dannelsen av stoffskiftehormon.Diverse kilder: • Mindre kjøtt, mer plantebasert: Her kommer De nordiske ernæringsanbefalingene 2023 • Helsedirektoratets kostråd • The Seven Countries Study (søk) • Paleo diet (søk) • Keto diet (søk) • Carnivore diet (søk)› Relaterte AJP-episoder: • AJP 61 | Sjur Even Aunmo – Fikk sparken for å snakke om bivirkningerRelatert forskning:› FETT› https://doi.org/10.1136/bmj.e8707 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis› https://doi.org/10.1136/bmj.i1246 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)› https://doi.org/10.3945/ajcn.2009.27725 Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease› https://doi.org/10.1186/s12937-017-0254-5 The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials› https://doi.org/10.1016/j.jacc.2020.05.077 Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review› http://dx.doi.org/10.1136/openhrt-2014-000196 Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis› http://dx.doi.org/10.1136/bmjebm-2019-111180 Fat or fiction: the diet-heart hypothesis› https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html› https://doi.org/10.1046/j.1471-4159.1997.68052092.x 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease› https://doi.org/10.1016/j.freeradbiomed.2006.07.021 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids› https://doi.org/10.1038/s41467-018-05614-6 Dietary stearic acid regulates mitochondria in vivo in humans› http://dx.doi.org/10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health› https://doi.org/10.1194/jlr.M026179 Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells› https://doi.org/10.1021/jf049207s Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER (KOLESTEROLSENKENDE STOFFER)› http://dx.doi.org/10.1136/bmjopen-2018-023085 Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews› http://dx.doi.org/10.1136/bmjopen-2014-007118 The effect of statins on average survival in randomised trials, an analysis of end point postponement› https://doi.org/10.1001/archinternmed.2010.182 Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants› https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999› https://www.felleskatalogen.no/medisin/zocor-organon-565655› https://www.legemiddelhandboka.no/L8.15.1/Statiner› https://www.bmj.com/campaign/statins-open-data Statins - a call for transparent data› https://doi.org/10.1001/archinternmed.2011.625 Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› https://doi.org/10.1007/s40264-017-0620-4 Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System› https://doi.org/10.1001/jamainternmed.2020.6084 Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years› https://doi.org/10.1016/j.atherosclerosis.2022.07.003 Statin therapy for the primary prevention of cardiovascular disease: Cons› http://doi.org/10.1161/STROKEAHA.121.034576 Lipid-Lowering Therapy and Hemorrhagic Stroke RiskLipid-Lowering Therapy and Hemorrhagic Stroke Risk› KJØTT› https://www.acpjournals.org/doi/full/10.7326/M19-0622 Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials› https://doi.org/10.3945/ajcn.116.142521 Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› https://doi.org/10.3945/ajcn.113.062638 Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies› FISK› https://doi.org/10.1093/jn/nxab112 Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children› https://doi.org/10.1007/s12016-013-8363-1 Fish Allergy: In Review› KOLESTEROL› http://dx.doi.org/10.1136/bmjopen-2015-010401 Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review› https://doi.org/10.1016/j.mehy.2018.09.019 Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia› PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis› https://doi.org/10.1016/0021-9150(89)90130-5 Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages› https://doi.org/10.1161/01.CIR.93.7.1346 Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL› https://doi.org/10.1161/01.CIR.97.20.2012 Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein› https://doi.org/10.1016/j.atherosclerosis.2008.04.046 Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review› https://doi.org/10.1161/ATVBAHA.113.300156 Smoking and Cardiovascular Disease› https://doi.org/10.3402/fnr.v59.29240 LDL biochemical modifications: a link between atherosclerosis and aging› https://doi.org/10.1016/j.cjca.2017.07.015 Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› https://doi.org/10.1054/plef.2000.0204 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study.› KARBOHYDRAT› https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› FRUKTOSE› https://doi.org/10.1016/j.jhep.2021.02.027 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial› https://doi.org/10.1093/ajcn/nqaa332 Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› https://doi.org/10.5223/pghn.2021.24.5.483 The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity› KUNSTIG SØTNING› https://doi.org/10.1016/s0378-8741(99)00081-1 Effects of chronic administration of Stevia rebaudiana on fertility in rats› https://doi.org/10.1371/journal.pone.0000698 Intense Sweetness Surpasses Cocaine Reward› https://doi.org/10.1016/j.cell.2022.07.016 Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance› https://doi.org/10.1289/ehp.8711 First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats› https://doi.org/10.1289/ehp.10271 Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats› DIABETES› https://doi.org/10.1001/jama.295.6.655 Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett› https://doi.org/10.3945/ajcn.110.010843 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial› https://doi.org/10.1007/s11745-008-3274-2 AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet› https://doi.org/10.1161/ATVBAHA.114.303284 Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort› https://doi.org/10.1097/MOL.0b013e328306a057 Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology› https://doi.org/10.1016/0021-9150(93)90084-8 Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?› https://doi.org/10.2337/diabetes.55.02.06.db05-1103 Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› https://doi.org/10.1016/S0895-7061(00)01260-7 Blood viscosity and blood pressure: role of temperature and hyperglycemia› https://doi.org/10.2337/dc13-1374 Blood Viscosity in Subjects With Normoglycemia and Prediabetes› https://doi.org/10.1007/s00592-017-1004-z Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity› https://doi.org/10.1080/09674845.2010.11730293 Blood viscosity at different stages of diabetes pathogenesis.› DIABETES-DEMENS› https://doi.org/10.1212/WNL.53.9.1937 Diabetes mellitus and the risk of dementia - The Rotterdam Study› https://doi.org/10.1016/S1474-4422(05)70284-2 Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review› https://doi.org/10.1111/j.1445-5994.2012.02758.x Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies› https://doi.org/10.1016/j.arr.2019.100944 Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies› https://doi.org/10.1177/193229680800200619 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed› https://doi.org/10.3390/ijerph120708281 Evaluating the Association between Diabetes, Cognitive Decline and Dementia› https://doi.org/10.3390/ijms21030934 Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model› https://doi.org/10.1038/s41574-018-0048-7 Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications› https://doi.org/10.1038/s41586-020-2247-3 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline› DIABETES NYRESYKDOM› https://doi.org/10.2337/diacare.27.2007.S79 Nephropathy-in-Diabetes Nephropathy in Diabetes› Diabetic Nephropathy: Diagnosis, Prevention, and Treatment› https://doi.org/10.1016/S0272-6386(96)90538-7 Diabetic nephropathy in type II diabetes› DIABETES ØYESYKDOM› https://doi.org/10.1016/S0140-6736(09)62124-3 Diabetic retinopathy› https://doi.org/10.1016/S2213-8587(18)30128-1 Incidence and progression of diabetic retinopathy: a systematic review› DIABETES HJERTE- OG KAR-SYKDOM› https://doi.org/10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF, VERN OG GIFT› https://doi.org/10.1016/j.foodchem.2008.01.056 Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols› https://doi.org/10.1002/mnfr.200900099 Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis.› https://doi.org/10.1046/j.1440-6047.1999.00038.x Oxalate content of foods and its effect on humans› https://doi.org/10.1104/pp.109.2.347 Lectins as plant defense proteins.› https://doi.org/10.1016/j.taap.2009.03.012 Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› https://doi.org/10.1038/s41531-018-0066-0 Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› https://doi.org/10.1016/S0140-6736(05)79894-9 Identification of intact peanut lectin in peripheral venous blood› https://doi.org/10.1136/bmj.318.7190.1023 Do dietary lectins cause disease?› https://doi.org/10.1016/S0015-0282(16)54596-8 Lectin binding of endometrium in women with unexplained infertility› https://doi.org/10.1016/S0271-5317(88)80133-7 Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins› https://doi.org/10.3390/molecules20022014 Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection› https://doi.org/10.1210/endo-113-6-1921 Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities› https://doi.org/10.1042/BJ20071137 Contribution of leptin receptor N-linked glycans to leptin binding› https://doi.org/10.1111/j.1365-2249.2007.03368.x Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E› https://doi.org/10.1002/(SICI)1521-4141(199903)29:03 Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils› https://doi.org/10.1016/j.ekir.2018.07.020 Secondary Oxalate Nephropathy: A Systematic Review› http://dx.doi.org/10.1136/gut.16.3.193 The effect of tea on iron absorption.› PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.› https://doi.org/10.1016/0887-2333(95)00113-1 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro› https://doi.org/10.1079/BJN2002725 The biological action of saponins in animal systems: a review› http://doi.org/10.1093/carcin/bgp082 Lung tumor promotion by curcumin› https://doi.org/10.3945/ajcn.2009.26736M Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)› https://doi.org/10.3382/ps.0550716 Antithyroid Activity of Goitrin in Chicks› https://doi.org/10.1016/s0278-6915(82)80294-9 Hepatic effects of R-goitrin in in Sprague-Dawley rats› https://doi.org/10.1002/ana.24448 Vagotomy and subsequent risk of Parkinson's disease --> https://doi.org/10.1038/s41531-018-0066-0› Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› http://doi.org/10.1056/NEJMra2010852 Salicylate Toxicity› https://doi.org/10.1021/jf0113070 Relationship between Cyanogenic Compounds in Kernels, Leaves, and Roots of Sweet and Bitter Kernelled Almonds› https://doi.org/10.1179/146532810X12637745451951Cyanide poisoning caused by ingestion of apricot seeds› https://doi.org/10.3390/toxins11060324 Ricin: An Ancient Story for a Timeless Plant Toxin› https://doi.org/10.1016/j.taap.2009.03.012Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› GLUTEN› https://doi.org/10.1080/00365520500235334 Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines› https://doi.org/10.1053/j.gastro.2008.03.023 Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3› https://doi.org/10.1016/j.jprot.2017.03.026 A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods› https://doi.org/10.1111/jgh.13703 What is gluten?› https://doi.org/10.1186/s41043-015-0032-y The opioid effects of gluten exorphins: asymptomatic celiac disease› https://doi.org/10.1016/j.peptides.2015.07.013 Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects› SOYA› https://doi.org/10.1271/bbb.70516Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities.› TILSETNINGSSTOFFER› https://doi.org/10.3233/NHA-170023 A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity› https://doi.org/10.1053/j.gastro.2021.11.006 Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome› https://doi.org/10.1002/ijc.21925 Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women› KETOGENISITET/KREFT› https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse› https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html› https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect› https://doi.org/10.1016/j.tibs.2015.12.001 The Warburg Effect: How Does it Benefit Cancer Cells?› https://doi.org/10.1080/01635581.2019.1650942 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study› https://doi.org/10.1093/jnci/djs399 Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803› https://doi.org/10.18632/aging.101382 Ketogenic diet in cancer therapy› IATROGENISITET› https://doi.org/10.1111/eci.12834 How to survive the medical misinformation mess› https://doi.org/10.1111/jlme.12068 Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs› https://doi.org/10.1136/bmj.f3830 Why we can't trust clinical guidelines› https://doi.org/10.1016/S0140-6736(15)60696-1 Offline: What is medicine's 5 sigma?› https://apjcn.nhri.org.tw/server/apjcn/procnutsoc/1990-1999/1995/1995%20p1-10.pdfLast ned episodenInnspilt: 2023-07-18Publisert: 2023-07-28Støtte Antijantepodden?Liker du arbeidet vi gjør, og vil bidra til at vi lager flere episoder?Finn ut hvordan du kan gi noe tilbake ved å gå til antijantepodden.com!Meld deg på vårt nyhetsbrev
Quelle est l'importance de la prise en charge des maladies auto-immunes systémiques par les rhumatologues ? Quel article portant sur le lupus systémique a marqué l'année 2022 ? Quel article portant sur le syndrome de Sjögren a marqué 2022 ? Quel article portant sur la sclérodermie a marqué 2022 ? Quelle conclusion apporter sur ces trois articles ? Le Pr Xavier Mariette, rhumatologue dans le service de Rhumatologie à l'hôpital du Kremlin-Bicêtre (Université Paris Saclay), et médecin coordonnateur du Centre National de Référence des Maladies Auto-Immunes Systémiques Rares constitutif pour le syndrome de Sjögren, répond à vos questions. Invité : Pr Xavier Mariette – Hôpital Bicêtre – Le Kremlin-Bicêtre https://www.aphp.fr/service/service-04-010 https://maladiesrares-paris-saclay.aphp.fr/centre-de-reference-des-maladies-auto-immunes-systemiques-rares/ Le Pr Mariette déclare des liens d'intérêts avec les laboratoires Astra Zenaca, BMS, Galapagos, GSK Novartis, Pfizer. L'équipe : Comité scientifique : Pr Jérémie Sellam, Pr Thao Pham, Dr Catherine Beauvais, Dr Véronique Gaud-Listrat, Dr Céline Vidal, Dr Sophie Hecquet Animation : Pyramidale Communication Production : Pyramidale Communication Soutien institutionnel : Pfizer Crédits : Pyramidale Communication, Sonacom Articles cités : 1. Vital EM, Merrill JT, Morand EF, Furie RA, Bruce IN, Tanaka Y, Manzi S, Kalunian KC, Kalyani RN, Streicher K, Abreu G, Tummala R. Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials. Ann Rheum Dis. 2022 Jul;81(7):951-961. doi: 10.1136/annrheumdis-2021-221425. Epub 2022 Mar 25. PMID: 35338035; PMCID: PMC9213795. 2. Mariette X, Barone F, Baldini C, Bootsma H, Clark KL, De Vita S, Gardner DH, Henderson RB, Herdman M, Lerang K, Mistry P, Punwaney R, Seror R, Stone J, van Daele P, van Maurik A, Wisniacki N, Roth DA, Tak PP. A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren's syndrome. JCI Insight. 2022 Dec 8;7(23):e163030. doi: 10.1172/jci.insight.163030. PMID: 36477362. 3. Maher TM, Tudor VA, Saunders P, Gibbons MA, Fletcher SV, Denton CP, Hoyles RK, Parfrey H, Renzoni EA, Kokosi M, Wells AU, Ashby D, Szigeti M, Molyneaux PL; RECITAL Investigators. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial. Lancet Respir Med. 2022 Nov 11:S2213-2600(22)00359-9. doi: 10.1016/S2213-2600(22)00359-9. Epub ahead of print. PMID: 36375479
Mervyn Singer is a ludicrously busy and accomplished intensivist and professor at University College London. He is a prolific and provocative publisher, researcher and innovator, and our go to guy for all things Sepsis, Syndromes and (basic) Science. This is a fun and informative chat: many thanks Merv! Further Reading: 1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287 2. Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):775-787. doi:10.1001/jama.2016.0289 3. Póvoa P, Coelho L, Dal-Pizzol F, et al. How to use biomarkers of infection or sepsis at the bedside: guide to clinicians. Intensive Care Med. 2023;49(2):142-153. doi:10.1007/s00134-022-06956-y 4. Singer M. Personalizing Sepsis Care. Crit Care Clin. 2018;34(1):153-160. doi:10.1016/j.ccc.2017.08.011 5. Singer M. Sepsis: personalization v protocolization?. Crit Care. 2019;23(Suppl 1):127. Published 2019 Jun 14. doi:10.1186/s13054-019-2398-5 6. Morelli A, Ertmer C, Westphal M, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310(16):1683-1691. doi:10.1001/jama.2013.278477 7. Singer M, Shipley R, Baker T, Cowell A, Brealey D, Lomas D. The UCL Ventura CPAP device for COVID-19. Lancet Respir Med. 2020;8(11):1076-1078. doi:10.1016/S2213-2600(20)30422-7
JACI: In Practice Editor-in-Chief Michael Schatz describes the January issue, which is a special issue celebrating the first 10 years of publication of the Journal, 2013-2022. The issue contains articles describing the most important advances of the past decade in the spectrum of illnesses covered in the Journal pages over the past 10 years. The conditions covered in these state-of-the-art reviews include asthma (diagnosis, and management in children and adults), allergic and non-allergic rhinitis (along with immunotherapy), chronic rhinosinusitis, anaphylaxis, atopic dermatitis, food allergy and eosinophilic gastrointestinal diseases, drug hypersensitivity, urticaria and angioedema, and immunodeficiency. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of asthma, dermatitis, food allergy, immunodeficiency, and rhinitis and sinusitis. Read the issue: https://www.jaci-inpractice.org/issue/S2213-2198(22)X0002-0 Access JACI: In Practice's entire library: https://www.jaci-inpractice.org
Quelle est l'importance de la prise en charge des maladies auto-immunes systémiques par les rhumatologues ? Quel article portant sur le lupus systémique a marqué l'année 2022 ? Quel article portant sur le syndrome de Sjögren a marqué 2022 ? Quel article portant sur la sclérodermie a marqué 2022 ? Quelle conclusion apporter sur ces trois articles ? Le Pr Xavier Mariette, rhumatologue dans le service de Rhumatologie à l'hôpital du Kremlin-Bicêtre (Université Paris Saclay), et médecin coordonnateur du Centre National de Référence des Maladies Auto-Immunes Systémiques Rares constitutif pour le syndrome de Sjögren, répond à vos questions. Invité : Pr Xavier Mariette – Hôpital Bicêtre – Le Kremlin-Bicêtre https://www.aphp.fr/service/service-04-010 https://maladiesrares-paris-saclay.aphp.fr/centre-de-reference-des-maladies-auto-immunes-systemiques-rares/ Le Pr Mariette déclare des liens d'intérêts avec les laboratoires Astra Zenaca, BMS, Galapagos, GSK Novartis, Pfizer. L'équipe : Comité scientifique : Pr Jérémie Sellam, Pr Thao Pham, Dr Catherine Beauvais, Dr Véronique Gaud-Listrat, Dr Céline Vidal, Dr Sophie Hecquet Animation : Pyramidale Communication Production : Pyramidale Communication Soutien institutionnel : Pfizer Crédits : Pyramidale Communication, Sonacom Articles cités : 1. Vital EM, Merrill JT, Morand EF, Furie RA, Bruce IN, Tanaka Y, Manzi S, Kalunian KC, Kalyani RN, Streicher K, Abreu G, Tummala R. Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials. Ann Rheum Dis. 2022 Jul;81(7):951-961. doi: 10.1136/annrheumdis-2021-221425. Epub 2022 Mar 25. PMID: 35338035; PMCID: PMC9213795. 2. Mariette X, Barone F, Baldini C, Bootsma H, Clark KL, De Vita S, Gardner DH, Henderson RB, Herdman M, Lerang K, Mistry P, Punwaney R, Seror R, Stone J, van Daele P, van Maurik A, Wisniacki N, Roth DA, Tak PP. A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren's syndrome. JCI Insight. 2022 Dec 8;7(23):e163030. doi: 10.1172/jci.insight.163030. PMID: 36477362. 3. Maher TM, Tudor VA, Saunders P, Gibbons MA, Fletcher SV, Denton CP, Hoyles RK, Parfrey H, Renzoni EA, Kokosi M, Wells AU, Ashby D, Szigeti M, Molyneaux PL; RECITAL Investigators. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial. Lancet Respir Med. 2022 Nov 11:S2213-2600(22)00359-9. doi: 10.1016/S2213-2600(22)00359-9. Epub ahead of print. PMID: 36375479
JACI: In Practice Editor-in-Chief Michael Schatz describes the December issue, the theme of which is “Adverse Effects of Drugs Used in Allergy and Immunology Practice”. Theme topics covered include an overview of the FDA labeling and approval process, FDA boxed warnings and the off-label use of medications, the safety of commonly used allergy and asthma medications in children, safety considerations for natural products commonly used by patients with allergic disease, and safety issues regarding medications for refractory chromic urticaria, biologics, proton pump inhibitors, and diphenhydramine. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of anaphylaxis, asthma, dermatitis, drug allergy, food allergy, and urticaria and angioedema. Read the issue: https://www.jaci-inpractice.org/issue/S2213-2198(21)X0024-4Access JACI: In Practice's entire library: https://www.jaci-inpractice.org
First up, in Poppin' Culture, we discuss Gisele and Tom's divorce and the work and family balance. Next, we do an Academic Deep Dive into the new Journal of Allergy and Clinical Immunology: In Practice research on changes in caregiver depression and child asthma symptoms. Last up, we discuss relationship advice on how to avoid conflict when decorating your house….. We rate some of it as Good, and some of it…not so Good. Based on science, of course.Academic Deep Dive: Herehttps://www.jaci-inpractice.org/article/S2213-2198(22)00952-7/fulltextGood or Bad Advice: Article: here https://www.worthingcourtblog.com/compromise-over-decorating/ Youtube: HereWe also have a bonus Good or Bad Advice segment for our Patreon subscribers! Please, consider subscribing: here
About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.How to support PedsCrit:Please rate and review on Spotify or Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Objectives for this series:By the end of listening to this three-part series, learners should be able to:Recall the diagnostic criteria for pediatric acute respiratory distress syndrome (PARDS). Recall many of different direct and indirect causes of PARDS.Recall the methods used to stratify the severity of PARDS.Recognize the limitations of P/F ratios and the clinical utility of instead using oxygenation index (OI).Describe the rationale and limitations of adjunctive therapies for moderate to severe PARDS.CitationsPediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2015;16(5):428-439. doi:10.1097/PCC.0000000000000350 Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators, & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2019). Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. The Lancet. Respiratory medicine, 7(2), 115–128. https://doi.org/10.1016/S2213-2600(18)30344-8Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updatesSupport the show
About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.How to support PedsCrit:Please rate and review on Spotify or Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Objectives for this series:By the end of listening to this three-part series, learners should be able to:Recall the diagnostic criteria for pediatric acute respiratory distress syndrome (PARDS). Recall many of different direct and indirect causes of PARDS.Recall the methods used to stratify the severity of PARDS.Recognize the limitations of P/F ratios and the clinical utility of instead using oxygenation index (OI).Describe the rationale and limitations of adjunctive therapies for moderate to severe PARDS.CitationsPediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2015;16(5):428-439. doi:10.1097/PCC.0000000000000350 Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators, & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2019). Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. The Lancet. Respiratory medicine, 7(2), 115–128. https://doi.org/10.1016/S2213-2600(18)30344-8Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updatesSupport the show
About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.How to support PedsCrit:Please rate and review on Spotify or Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Objectives for this series:By the end of listening to this three-part series, learners should be able to:Recall the diagnostic criteria for pediatric acute respiratory distress syndrome (PARDS). Recall many of different direct and indirect causes of PARDS.Recall the methods used to stratify the severity of PARDS.Recognize the limitations of P/F ratios and the clinical utility of instead using oxygenation index (OI).Describe the rationale and limitations of adjunctive therapies for moderate to severe PARDS.CitationsPediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2015;16(5):428-439. doi:10.1097/PCC.0000000000000350 Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators, & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2019). Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. The Lancet. Respiratory medicine, 7(2), 115–128. https://doi.org/10.1016/S2213-2600(18)30344-8Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updatesSupport the show
In patients who are immunocompromised, we must determine whether using high flow oxygen (HFNC/NHF/HFO) or NIV would better serve our patients Show Notes: https://eddyjoemd.com/high-flow-immunocompromised/ Although great care has been taken to ensure that the information in this podcast are accurate, eddyjoe, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom. Citation: Bourenne J, Girault C, Vinsonneau C, Dellamonica J, Labro G, Jochmans S, Herbland A, Quenot JP, Devaquet J, Benzekri D, Vivier E, Nseir S, Colin G, Thevenin D, Grasselli G, Bougon D, Assefi M, Guérin C, Lherm T, Kouatchet A, Ragot S, Thille AW; FLORALI-IM study group and the REVA Research Network. High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial. Lancet Respir Med. 2022 Mar 21:S2213-2600(22)00096-0. doi: 10.1016/S2213-2600(22)00096-0. Epub ahead of print. PMID: 35325620. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/eddyjoemd/support
Description: A year ago, we published an episode looking at diabetes management in the context of ongoing restrictions in many parts of the world. Since then, a wealth of clinical data has continued to be published on the bidirectional relationship between diabetes and Covid-19, so today we're taking a closer look at these data. We're joined by Professor Partha Kar, National Specialty Advisor, Diabetes for NHS England, to discuss what the data mean for clinical practice. By completing this activity you can qualify for 0.25 CME credits. To claim your credits, you must listen to the podcast and successfully pass the post-module assessment at https://diabetes.knowledgeintopractice.com, where you can find all past episodes of the podcast as well as other free CME resources. References: Kamrath C, et al. Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry. Diabetes Care. 2022 Jan 17:dc210969. Gottesman BL, et al. Incidence of New-Onset Type 1 Diabetes Among US Children During the COVID-19 Global Pandemic. JAMA Pediatr. 2022 Apr 1;176(4):414-415. McGlacken-Byrne SM, et al. The SARS-CoV-2 pandemic is associated with increased severity of presentation of childhood onset type 1 diabetes mellitus: A multi-centre study of the first COVID-19 wave. Diabet Med. Sep 2021;38(9):e14640. Barrett CE, et al. Risk for Newly Diagnosed Diabetes >30 Days After SARS-CoV-2 Infection Among Persons Aged
Coronary CTA, semaglutide, coronary artery calcium, exercise, and an ACC and EHRA preview are the topics discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I – Coronary CTA Feedback - Coronary Computed Tomography Angiography vs Functional Stress Testing for Patients With Suspected Coronary Artery Disease https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243 II – Semaglutide - FDA Okays Semaglutide Higher Dose, 2 mg/Week, for Type 2 Diabetes https://www.medscape.com/viewarticle/971156 - Efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial https://doi.org/10.1016/S2213-8587(21)00174-1 - Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa1607141 - Once-Weekly Semaglutide in Adults with Overweight or Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 III – CAC and SCD - Calcium Scores Predict Sudden-Death Risk in Preclinical CAD in Large Cohort Study https://www.medscape.com/viewarticle/971056 - Coronary Artery Calcium for Risk Stratification of Sudden Cardiac Death: The Coronary Artery Calcium Consortium https://www.jacc.org/doi/10.1016/j.jcmg.2022.02.011 IV – Exercise and COVID-19 - More Exercise Linked to Lower Chance of Severe COVID-19: Study https://www.medscape.com/viewarticle/949468 - Small steps, strong shield: directly measured, moderate physical activity in 65 361 adults is associated with significant protective effects from severe COVID-19 outcomes http://dx.doi.org/10.1136/bjsports-2021-105159 V – ACC Preview - Hybrid ACC.22 Resurrects the Live Scientific Session https://www.medscape.com/viewarticle/971083 - Mandrola Previews the 2022 American College of Cardiology Scientific Sessions https://www.medscape.com/viewarticle/971084 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net
Après avoir parlé du Paxlovid, on s'intéresse aux thérapies alternatives contre la COVID. Quelles sont les données d'efficacité concernant le remdésivir, la fluvoxamine et le budésonide inhalé? Quelles clientèles peuvent bénéficier de ces traitements? On en discute avec Jean-François Tessier, pharmacien à l'hôpital Maisonneuve-Rosemont du CIUSSS de l'Est-de-l'Ile de Montréal et président du RPE d'infectiologie de l'A.P.E.S. RÉFÉRENCES : Anil Gupta A, Gonzalez-Rojas Y, Juarez E et al. Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab. N Engl J Med 2021; 385:1941-1950. DOI: 10.1056/NEJMoa2107934. Hammond J, Leister-Tebbe H, Gardner A et al. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19. N Engl J Med 2022 (February). DOI: 10.1056/NEJMoa2118542. Lee T C, Morris M, Grover A S et al. Outpatient therapies for COVID-19: How do we choose? medRxiv 2021.12.17.21268007. DOI: 10.1101/2021.12.17.21268007 Canadian Treatments for COVID-19 for the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network and the Canadian Critical Care Trials Group. Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial. CMAJ February 22, 2022 194 (7) E242-E251; DOI: 10.1503/cmaj.211698 Sanjay Ramakrishnan S, Nicolau Jr D V, Langford B et al. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial. The Lancet Respiratory Medicine, volume 9, issue 7, p763-772, july 01, 2021. DOI: 10.1016/S2213-2600(21)00160-0 Robert L. Gottlieb, R, Vaca C E, Paredes R et al. Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients. N Engl J Med 2022; 386:305-315. DOI: 10.1056/NEJMoa2116846. COVID-19 advisory for Ontario. Science table. https://covid19-sciencetable.ca
Xeno-transplantation, weight loss drugs, DOAC coverage, vitamin D, LAAC and frailty, and recalled LVADs are the topics John Mandrola, MD, discusses in this week's podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I – Xenotransplantation - Pig Heart Successfully Transplanted to Man https://www.medscape.com/viewarticle/966367 - What Does a Pig-to-Human Heart Transplant Mean for Medicine? https://www.medscape.com/viewarticle/966488 II – Weight Loss Drugs - Wegovy Tops Sibling Saxenda for Weight Loss https://www.medscape.com/viewarticle/966376 - Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes https://jamanetwork.com/journals/jama/article-abstract/2787907 III – DOAC Coverage - CVS Caremark Formulary Change Freezes Out Apixaban https://www.medscape.com/viewarticle/966588 IV – Vitamin D - More Vitamin D Not Better for Reducing Cancer or CVD Incidence https://www.medscape.com/viewarticle/966333 - The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality https://doi.org/10.1016/S2213-8587(21)00345-4 - Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial https://doi.org/10.1093/ajcn/nqab419 - Association between vitamin D supplementation and mortality: systematic review and meta-analysis https://www.bmj.com/content/366/bmj.l4673 V – LAAC and Frailty - Frailty in patients undergoing percutaneous left atrial appendage closure https://doi.org/10.1016/j.hrthm.2022.01.007 - Net Clinical Benefit of Left Atrial Appendage Closure Versus Warfarin in Patients With Atrial Fibrillation: A Pooled Analysis of the Randomized PROTECT-AF and PREVAIL Studies https://pubmed.ncbi.nlm.nih.gov/31752643/ VI – LVAD recall - A High-Risk Medical Device Didn't Meet Federal Standards. The Government Paid Millions for More. https://www.medscape.com/viewarticle/966255 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net This podcast is intended for US health professionals only.
At the beginning of the pandemic, the prevailing theory was that people with eczema would be at higher risk for COVID-19 infection and impacts because so many are using steroid treatments and also suffer from asthma, which many guessed would make respiratory infections worse. But, in a rare bit of good news, the exact opposite may be true! Tune in to learn how the immune system abnormalities associated with eczema may actually protect against COVID-19 infection and how one treatment may reduce the risk of severe symptoms after infection. Our guests are Dr. Emma Guttman-Yassky, Professor of Dermatology and Immunology at the Icahn School of Medicine at Mount Sinai; Dr. Benjamin Ungar Assistant Professor of Dermatology also at Mount Sinai; and Dr. Adrian Martineau Professor of Respiratory Infection and Immunity Sciences in the School of Medicine at Queen Mary University of London. Research referenced in this episode: https://www.jaci-inpractice.org/article/S2213-2198(21)01203-4/fulltext (COVID-19 Symptoms in Patients Treated with Dupilumab) https://thorax.bmj.com/content/early/2021/11/02/thoraxjnl-2021-217487 (Risk factors for developing COVID-19)
Listen to a 5-minute summary of a study investigating how mortality for type 1 and type 2 diabetes varies in an incident population in England and Wales, analysed by sex and age of diagnosis, published in the Lancet Diabetes and Endocrinology. A quick overview of the key findings is presented. Publication: Holman N, Wild SH, Gregg EW, Valabhji J, Sattar N, Khunti K; National Diabetes Audit Research Group. Comparison of mortality in people with type 1 and type 2 diabetes by age of diagnosis: an incident population-based study in England and Wales. Lancet Diabetes Endocrinol. 2021 Nov 22:S2213-8587(21)00293-X. doi: 10.1016/S2213-8587(21)00293-X. Epub ahead of print. Additional references: Chan JCN, Lim LL, Wareham NJ, et al. The Lancet Commission on diabetes: using data to transform diabetes care and patient lives. Lancet 2020; 396: 2019–82. Constantino MI, Molyneaux L, Limacher-Gisler F, et al. Long-term complications and mortality in young-onset diabetes: type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care. 2013; 36: 3863–69. For more free education, visit the DKIP website, follow us on Twitter (@dkipractice) or connect on LinkedIn. Funding statement: This independent educational activity is supported by an educational grant from Novo Nordisk A/S. The educational content has been developed by Liberum IME in conjunction with an independent steering committee; Novo Nordisk A/S has had no influence on the content of this education.
This podcast is sponsored by Anelto, a leading technology platform that enables innovative healthcare solutions to keep seniors connected to healthcare providers from anywhere. Visit www.anelto.com.Welcome to this episode of Physician's Weekly Podcast. My name is Dr. Rachel Giles, from Medicom Medical Publishers, in collaboration with Physician's Weekly. We have 3 great in-depth interviews for you this week covering a new trial with promising results to relieve common lower back pain, remote patient monitoring of senior citizens, and a trial showing that having COVID patients position themselves in the prone position, so-called “awake prone positioning”, has improved outcomes in patients with severe COVID-19. Todd Alamin, MD, spinal surgeon at Stanford University: About 140,000 back pain patients are treated with lumbar fusion in the US every year, and we discuss their clinical trial data suggesting that perioperative outcomes are far better using a perispinous tension band after decompression, as opposed to lumbar fusion after decompression, with at least identical, if not better, long term resultsLater in this episode, Physician's Weekly speaks with Jie Li, PhD, RRT, RRT-ACCS, RRT-NPS from Rush University in Chicago and Professor Stephan Ehrmann, MD, PhD, from the Intensive Care Unit at the University Hospital in Tours, France about their recent study published in the Lancet Respiratory Medicine looking at awake prone positioning in patients with severe COVID-19. In this prospectively designed, multicenter, international, randomized, open-label meta-trial, with a large sample size (1121 patients), these 2 researchers found that awake prone positioning reduced the incidence of treatment failure within 28 days of enrolment (the primary composite outcome of intubation or death) in patients with acute severe hypoxemic respiratory failure due to COVID-19 supported with high-flow nasal cannula.Also in this episode, our correspondent Dylan Prentner speaks with Mark Denissen , the President and Chief Executive Officer of Anelto about remote patient monitoring (RPM) of seniors by real-time symptom tracking. Anelto RemoteCare tracks patient engagement, identifies common requests, questions, and commands; and even tracks user responses and adherence to protocols with alerts and reminders.Technologies such as Remote Patient Monitoring are helping transform senior patient care, ensuring patient safety and well-being while continuing to live independently. Most RPM solutions are not developed specifically with the senior population in mind, especially those with chronic conditions. For seniors, RPM needs to be a complete solution that is easy to use with 24/7 access to care management providers. Visit www.anelto.com.Ehrmann S, Li J, et al; Awake Prone Positioning Meta-Trial Group. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021 Aug 20:S2213-2600(21)00356-8. Let us know what you thought of this week's episode on Twitter: @physicianswkly Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com! Thanks for listening!
During the COVID-19 pandemic, dietitians have had to adapt at a breakneck pace. We've learned a lot, but there's still so much to discover. In this episode, we answer the top 5 nutrition-related COVID-19 questions and address the latest research and recommendations. Follow us on social media by searching Dietitians On Demand on Instagram, Facebook and LinkedIn. Join our newsletter: https://bit.ly/2Wugmrt View our open jobs: https://bit.ly/3kvMm6S Shop Elevate by Dietitians On Demand: https://bit.ly/3klmZog Show Notes: On-Demand Webinar: Dietitians On Demand's COVID in the ICU: https://bit.ly/3gc4LEv Martindale R, Patel JJ, Taylor B, Arabi YM, Warren M, McClave SA. Nutrition Therapy in Critically Ill Patients With Coronavirus Disease 2019. JPEN J Parenter Enteral Nutr. 2020;44(7):1174-1184. doi:10.1002/jpen.1930 Mitchell F. Vitamin-D and COVID-19: do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020 Jul; 8(7): 570. Published online 2020 May 20. doi: 10.1016/S2213-8587(20)30183-2 Wiese OJ, Allwood BW, Zemlin AE. COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight? Med Hypotheses. 2020 Nov; 144; 110231. What It Means to Be a Coronavirus "Long-Hauler" Article: https://health.clevelandclinic.org/what-it-means-to-be-a-coronavirus-long-hauler/
Should we be proning COVID patients who are not intubated/spontaneously breathing? The short answer is yes. Prone positioning works. A hat tip to the authors! Show Notes: https://eddyjoemd.com/proning-covid/ Although great care has been taken to ensure that the information in this podcast are accurate, eddyjoe, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom. Website: www.eddyjoemd.com Instagram: www.instagram.com/eddyjoemd Twitter: www.twitter.com/eddyjoemd Facebook: www.facebook.com/eddyjoemd Podcast: https://anchor.fm/eddyjoemd My Amazon store for resources you may find helpful: www.amazon.com/shop/eddyjoemd Citation: Aguirre-Avalos G, Trump MW, Nay MA, Dellamonica J, Nseir S, Mogri I, Cosgrave D, Jayaraman D, Masclans JR, Laffey JG, Tavernier E; Awake Prone Positioning Meta-Trial Group. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021 Aug 20:S2213-2600(21)00356-8. doi: 10.1016/S2213-2600(21)00356-8. Epub ahead of print. PMID: 34425070; PMCID: PMC8378833. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/eddyjoemd/support
2021-06-29 / 60 MINUTER Ivermektin - vad vet vi om detta som så många pratar om just nu? Jan Lötvall och Leif Bjermer är kvällens panel. Länk till artikel om inhalationskortison som tidig behandling av COVID19: https://www.thelancet.com/article/S2213-2600(21)00160-0/fulltext Vill du stötta vårt arbete? Du kan bli medlem i Vetenskapsforum Covid-19 här: vetcov19.se/bli-medlem/ Du kan även donera till vårt arbete: vetcov19.se/donera/
In today's episode, we will talk about new research on the use of an induced pluripotent stem cell-based vaccine to potentially protect against pancreatic cancer. This approach takes advantage of shared antigens between stem cells and pancreatic cancer cells and seeks to exploit them for clinical benefit. We will talk with the authors of this new research published in Stem Cell Reports on why they decided to pursue this approach, the background behind it, and whether this approach could work for other types of cancers. We also discuss some of Dr. Wu's other work, including research on stem cells in microgravity. Show NotesGuestsJoseph Wu, MD, PhD Director of the Stanford Cardiovascular Institute, US Website: http://med.stanford.edu/wulab.htmlXiaoming Ouyang, PhD, Postdoctoral Scholar, Wu Laboratory, Stanford University, US Website: https://www.researchgate.net/profile/Xiaoming-OuyangHostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryWebsite: https://www.jax.org/research-and-faculty/faculty/martin-peraTwitter: @martinperaJAXSupporting DocumentsAnti-Tumor Effects of iPSC-Based Cancer Vaccine in Pancreatic Cancerhttps://www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00199-5About Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @stemcellreportsAbout ISSCRWith nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCR AcknowledgementsISSCR StaffKeith Alm, Chief Operating OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Senior Manager of Scientific AffairsNancy Witty, Chief Executive OfficerVoice WorkJulie PerlinBen SnitkoffMusic@Konovalov
In this episode of Critical Matters, we will discuss ICU Liberation and the A-F Bundles during the COVID-19 pandemic. Our guest is Dr. Wesley Ely (@WesElyMD), professor of medicine at Vanderbilt University School of Medicine. He is the co-director of the Center for Critical Illness, Brain dysfunction, and Survivorship (CIBS Center), which has enrolled thousands of patients into clinical trials, answering vital questions about ICU acquired brain disease and other components of ICU survivorship. Additional Resources: Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study: https://www.thelancet.com/action/showPdf?pii=S2213-2600%2820%2930552-X Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019: https://journals.lww.com/ccejournal/pages/articleviewer.aspx?year=2020&issue=06000&article=00016&type=Fulltext ABCDEF Bundle and Supportive ICU Practices for Patients With Coronavirus Disease 2019 Infection: An International Point Prevalence Study: https://journals.lww.com/ccejournal/fulltext/2021/03000/abcdef_bundle_and_supportive_icu_practices_for.12.aspx Link to the CIBS Center website, which contains a wealth of resources for intensivists on the topic of delirium: https://www.icudelirium.org Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults: https://www.ncbi.nlm.nih.gov/pubmed/?term=Caring+for+Critically+Ill+Patients+with+the+ABCDEF+Bundle%3A+Results+of+the+ICU+Liberation+Collaborative+in+Over+15%2C000+Adults Books Mentioned in this Episode: Arrowsmith by Sinclair Lewis: https://www.amazon.com/Arrowsmith-Sinclair-Lewis/dp/B08VYFJVC7/ref=sr_1_3_sspa?crid=D2EL30QJYDN9&dchild=1&keywords=lewis+sinclair&qid=1619044221&sprefix=lewis+sin%2Caps%2C158&sr=8-3-spons&psc=1&spLa=ZW5jcnlwdGVkUXVhbGlmaWVyPUEyMlBCNlBVUkI0RjI1JmVuY3J5cHRlZElkPUEwOTQwMTcyMTE3UVZGRVlDSjhDRyZlbmNyeXB0ZWRBZElkPUExMDI5MDI2M0VBREtVSEFQNE5OViZ3aWRnZXROYW1lPXNwX2F0ZiZhY3Rpb249Y2xpY2tSZWRpcmVjdCZkb05vdExvZ0NsaWNrPXRydWU East of Eden by John Steinbeck: https://www.amazon.com/East-Eden-John-Steinbeck-ebook/dp/B08YLXQ2BC/ref=sr_1_1?dchild=1&keywords=east+of+eden&qid=1619044327&sr=8-1 Extreme Measures by Jessica Nutik Zitter: https://www.amazon.com/Extreme-Measures-Finding-Better-Path-ebook/dp/B01KGZVQOM/ref=sr_1_1?dchild=1&keywords=extreme+measures&qid=1619044537&s=books&sr=1-1 Knocking on Heaven's Door by Katy Butler: https://www.amazon.com/Knocking-Heavens-Door-Better-Death-ebook/dp/B00A285OF6/ref=sr_1_1?dchild=1&keywords=knocking+on+heavens+door&qid=1619044674&s=books&sr=1-1
In this episode Drs. Janet Rossant and Patrick Tam, join the podcast. They are experts in early embryonic development and authors of new Perspective article in Stem Cell Reports, Opportunities and Challenges with Stem Cell-Based Embryo Models. Embryo modeling is a rapidly emerging area of science which can help advance the understanding of early development, especially human development where insight has been limited due to technical and ethical issues. The article is online now and will appear in the May 2021 special issue of the journal.Show NotesGuestsJanet Rossant, PhD - Hospital for Sick Children, the University of Toronto and the Gairdner Foundation. Website: https://lab.research.sickkids.ca/rossant/Patrick Tam, PhD - University of Sydney, Australia Website: https://www.cmrijeansforgenes.org.au/researchers/patrick-tamHostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryWebsite: https://www.jax.org/research-and-faculty/faculty/martin-peraTwitter: @martinperaJAX (https://twitter.com/martinperajax) Podcast Website: https://thestemcellreport.buzzsprout.com/Supporting ResourcesOpportunities and Challenges with Stem Cell-Based Embryo ModelsWebsite: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00082-5 DOI: https://doi.org/10.1016/j.stemcr.2021.02.002NIH Blog Website: https://osp.od.nih.gov/2021/03/11/human-embryo-development/About Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Website: https://www.cell.com/stem-cell-reports/homeTwitter: @stemcellreports (https://twitter.com/stemcellreports)About ISSCRWith nearly 4,000 members from more than 60 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health. Website: International Society for Stem Cell ResearchTwitter: @ISSCR (https://twitter.com/isscr)AcknowledgementsISSCR StaffKeith Alm, Chief Operating OfficerBethany Almon, Senior Manager of Integrated MarketingYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director, Media and Strategic CommunicationsJack Mosher, Senior Manager, Scientific AffairsNancy Witty, Chief Executive OfficerVoice WorkBen SnitkoffMusicKonovalovMusic, @KonovalovMusic
Feature Interview (7:04) – Pediatric gastroenterologist Dr. Kim-Doan Katrina Nguyen talks about the growing problem of childhood obesity in the US and other parts of the world including the most common causes, the health consequences, and best practices to avoid or overcome weight problems in children. https://faithful2fitness.org/ Medical Trivia (Answer at 47:55) – In the largest study looking at the relationship between Body Mass Index (BMI) and health, the life-expectancy for those in the “healthy” BMI range was just over 82 years. How many years of expected life were lost in the overweight group, underweight group, and obese group? “Association of BMI with overall and cause-specific mortality” https://doi.org/10.1016/S2213-8587(18)30288-2 ------ www.redeemerradio.com www.cathmed.org Follow us on Facebook: @DoctorDoctorShow Submit your question(s): Text (Holy Cross College text line) – 260-436-9598 E-mail – Doctor@RedeemerRadio.com Subscribe to the Podcast: iTunes | Google Play | SoundCloud | RSS
In this episode, we explore the evidence on whether lower intraoperative tidal volumes (e.g., 6 vs. 9 cc/kg) reduce postoperative pulmonary complications. Our guest is Dr. Avery Tung. Dr. Tung is Professor of Anesthesia & Critical Care at the University of Chicago and Section Editor for Critical Care & Resuscitation for Anesthesia & Analgesia. Thanks for listening! If you enjoy our content, consider supporting our mission at https://bit.ly/3n0sklh. — Follow us on Instagram @DepthofAnesthesia and on Twitter @DepthAnesthesia. Email us at depthofanesthesia@gmail.com. Music by Stephen Campbell, MD. — References Karalapillai D, Weinberg L, Peyton P, et al. Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial. JAMA. 2020;324(9):848–858. doi:10.1001/jama.2020.12866 Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1301-8. doi: 10.1056/NEJM200005043421801. PMID: 10793162. Brower RG, Shanholtz CB, Fessler HE, Shade DM, White P Jr, Wiener CM, Teeter JG, Dodd-o JM, Almog Y, Piantadosi S. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med. 1999 Aug;27(8):1492-8. doi: 10.1097/00003246-199908000-00015. PMID: 10470755. Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998 Feb 5;338(6):347-54. doi: 10.1056/NEJM199802053380602. PMID: 9449727. Tobin MJ. Culmination of an era in research on the acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1360-1. doi: 10.1056/NEJM200005043421808. PMID: 10793169. Serpa Neto A, Cardoso SO, Manetta JA, Pereira VG, Espósito DC, Pasqualucci Mde O, Damasceno MC, Schultz MJ. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA. 2012 Oct 24;308(16):1651-9. doi: 10.1001/jama.2012.13730. PMID: 23093163. Futier E, Constantin JM, Paugam-Burtz C, Pascal J, Eurin M, Neuschwander A, Marret E, Beaussier M, Gutton C, Lefrant JY, Allaouchiche B, Verzilli D, Leone M, De Jong A, Bazin JE, Pereira B, Jaber S; IMPROVE Study Group. A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med. 2013 Aug 1;369(5):428-37. doi: 10.1056/NEJMoa1301082. PMID: 23902482. Serpa Neto A, Hemmes SN, Barbas CS, Beiderlinden M, Biehl M, Binnekade JM, Canet J, Fernandez-Bustamante A, Futier E, Gajic O, Hedenstierna G, Hollmann MW, Jaber S, Kozian A, Licker M, Lin WQ, Maslow AD, Memtsoudis SG, Reis Miranda D, Moine P, Ng T, Paparella D, Putensen C, Ranieri M, Scavonetto F, Schilling T, Schmid W, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ; PROVE Network Investigators. Protective versus Conventional Ventilation for Surgery: A Systematic Review and Individual Patient Data Meta-analysis. Anesthesiology. 2015 Jul;123(1):66-78. doi: 10.1097/ALN.0000000000000706. PMID: 25978326. PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology, Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ. High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. Lancet. 2014 Aug 9;384(9942):495-503. doi: 10.1016/S0140-6736(14)60416-5. Epub 2014 Jun 2. PMID: 24894577; PMCID: PMC6682759. Marret E, Cinotti R, Berard L, Piriou V, Jobard J, Barrucand B, Radu D, Jaber S, Bonnet F; and the PPV study group: Protective ventilation during anaesthesia reduces major postoperative complications after lung cancer surgery: a double-blind randomised controlled trial. Eur J Anaesthesiol 2018; 35:727–35 Neto AS, Hemmes SN, Barbas CS, Beiderlinden M, Fernandez-Bustamante A, Futier E, Gajic O, El-Tahan MR, Ghamdi AA, Günay E, Jaber S, Kokulu S, Kozian A, Licker M, Lin WQ, Maslow AD, Memtsoudis SG, Reis Miranda D, Moine P, Ng T, Paparella D, Ranieri VM, Scavonetto F, Schilling T, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Amato MB, Costa EL, de Abreu MG, Pelosi P, Schultz MJ; PROVE Network Investigators. Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data. Lancet Respir Med. 2016 Apr;4(4):272-80. doi: 10.1016/S2213-2600(16)00057-6. Epub 2016 Mar 4. Erratum in: Lancet Respir Med. 2016 Jun;4(6):e34. PMID: 26947624.
Our guest today is Dr. Daniel Saddawi-Konefka, residency program director at Mass General. In this part II or II series on neuromuscular blockade, we investigate the claim that a train-of-four target of 90% is important to achieve prior to extubation. Connect with us @DepthAnesthesia on Twitter or email us at depthofanesthesia@gmail.com. Thanks for listening! Please rate us on iTunes and share with your colleagues. Music by Stephen Campbell, MD. -- References Naguib M, Kopman AF, Lien CA, Hunter JM, Lopez A, Brull SJ. A survey of current management of neuromuscular block in the United States and Europe. Anesth Analg. 2010;111(1):110-119. doi:10.1213/ANE.0b013e3181c07428 Ali HH, Kitz RJ. Evaluation of recovery from nondepolarizing neuromuscular block, using a digital neuromuscular transmission analyzer: preliminary report. Anesth Analg. 1973;52(5):740-745. Ali HH, Wilson RS, Savarese JJ, Kitz RJ. The effect of tubocurarine on indirectly elicited train-of-four muscle response and respiratory measurements in humans. Br J Anaesth. 1975;47(5):570-574. doi:10.1093/bja/47.5.570 Sundman E, Witt H, Olsson R, Ekberg O, Kuylenstierna R, Eriksson LI. The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium. Anesthesiology. 2000;92(4):977-984. doi:10.1097/00000542-200004000-00014 Eikermann M, Groeben H, Hüsing J, Peters J. Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockade. Anesthesiology. 2003;98(6):1333-1337. doi:10.1097/00000542-200306000-00006 Gopalaiah Venkatesh Kumar, Anita Pramod Nair, Hanuman Srinivasa Murthy, Koppa Ramegowda Jalaja, Karnate Ramachandra, Gundappa Parameshwara; Residual Neuromuscular Blockade Affects Postoperative Pulmonary Function. Anesthesiology 2012; 117:1234–1244 doi: https://doi.org/10.1097/ALN.0b013e3182715b80 Eriksson LI, Lennmarken C, Wyon N, Johnson A. Attenuated ventilatory response to hypoxaemia at vecuronium-induced partial neuromuscular block. Acta Anaesthesiol Scand. 1992;36(7):710-715. doi:10.1111/j.1399-6576.1992.tb03550.x Suzanne J. L. Broens, Martijn Boon, Chris H. Martini, Marieke Niesters, Monique van Velzen, Leon P. H. J. Aarts, Albert Dahan; Reversal of Partial Neuromuscular Block and the Ventilatory Response to Hypoxia: A Randomized Controlled Trial in Healthy Volunteers. Anesthesiology 2019; 131:467–476 doi: https://doi.org/10.1097/ALN.0000000000002711 Kopman AF, Yee PS, Neuman GG. Relationship of the train-of-four fade ratio to clinical signs and symptoms of residual paralysis in awake volunteers. Anesthesiology. 1997;86(4):765-771. doi:10.1097/00000542-199704000-00005 Glenn S. Murphy, Joseph W. Szokol, Jesse H. Marymont, Steven B. Greenberg, Michael J. Avram, Jeffery S. Vender, Margarita Nisman; Intraoperative Acceleromyographic Monitoring Reduces the Risk of Residual Meeting Abstracts and Adverse Respiratory Events in the Postanesthesia Care Unit. Anesthesiology 2008; 109:389–398 doi: https://doi.org/10.1097/ALN.0b013e318182af3b Butterly A, Bittner EA, George E, et al. Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge. BJA: British Journal of Anaesthesia. 2010 Sep;105(3):304-309. DOI: 10.1093/bja/aeq157. Section Editor(s): Brull, Sorin J.Murphy, Glenn S. MD; Szokol, Joseph W. MD; Marymont, Jesse H. MD; Greenberg, Steven B. MD; Avram, Michael J. PhD; Vender, Jeffery S. MD Residual Neuromuscular Blockade and Critical Respiratory Events in the Postanesthesia Care Unit, Anesthesia & Analgesia: July 2008 - Volume 107 - Issue 1 - p 130-137 doi: 10.1213/ane.0b013e31816d1268 Kirmeier E, Eriksson LI, Lewald H, et al. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study [published correction appears in Lancet Respir Med. 2018 Nov 6;:]. Lancet Respir Med. 2019;7(2):129-140. doi:10.1016/S2213-2600(18)30294-7
Dr RR Baliga's 'Got Knowledge Doc' PodKasts for Physicians | Vitamin D in COVID-19 | Not Medical Advice or Opinion The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients Ali Daneshkhah, Vasundhara Agrawal, Adam Eshein, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman doi: https://doi.org/10.1101/2020.04.08.20058578 Vitamin-D and COVID-19: do deficient risk a poorer outcome? Fiona Mitchell Published:May 20, 2020DOI:https://doi.org/10.1016/S2213-8587(20)30183-2
In the past two weeks, warnings, questions, and misinformation concerning COVID-19 and NSAID use have been spreading...no pun intended..virally. The pace of this evolving pandemic and the equally quick pace of the news and social media news cycle have meant that information and misinformation travel equally fast. Today we bring to you the story of how a letter in The Lancet led to a world of confusion. Host: Elizabeth Esty, MD Research By: Elizabeth Esty & Nathan Novotny Sound Editing By: Stephen Bahmani Time Stamps: 0:00 - COVID-19 Statistics 2:55 - The Lancet Letter: What Started the Rumor 4:10 - ACE Inhibitors & ARB's 5:00 - What The Lancet Letter Got Wrong 6:25 - Treatment of HTN and DM in China vs. the U.S. 9:13 - Do ACE Inhibitors Actually Increase ACE-2 Expression? 11:00 - The French Ministry of Health and Their Warning About NSAIDs 14:09 - Misinformation in the Age of COVID-19 15:09 - Potential Harms of Tylenol Use 16:11 - The Need for High-Quality Science to Overcome COVID-19 References: Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The Lancet Respiratory Medicine. March 2020:S2213260020301168. doi:10.1016/S2213-2600(20)30116-8 Kane S. Ibuprofen - Drug Usage Statistics, ClinCalc DrugStats Database. ClinCalc DrugStats Database. https://clincalc.com/DrugStats/Drugs/Ibuprofen. Published December 23, 2019. Accessed March 30, 2020. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. March 2020. doi:10.1016/j.cell.2020.02.052 Lu J, Lu Y, Wang X, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project). The Lancet. 2017;390(10112):2549-2558. doi:10.1016/S0140-6736(17)32478-9 Wang Zengwu, Chen Zuo, Zhang Linfeng, et al. Status of Hypertension in China. Circulation. 2018;137(22):2344-2356. doi:10.1161/CIRCULATIONAHA.117.032380 Hu C, Jia W. Diabetes in China: Epidemiology and Genetic Risk Factors and Their Clinical Utility in Personalized Medication. Diabetes. 2018;67(1):3-11. doi:10.2337/dbi17-0013 Yuan H, Li X, Wan G, et al. Type 2 diabetes epidemic in East Asia: a 35-year systematic trend analysis. Oncotarget. 2018;9(6). doi:10.18632/oncotarget.22961 Woo KS, Nicholls MG. High prevalence of persistent cough with angiotensin converting enzyme inhibitors in Chinese. Br J Clin Pharmacol. 1995;40(2):141-144. Chen X, Hu W, Ling J, et al. Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients. medRxiv. March 2020:2020.03.22.20040774. doi:10.1101/2020.03.22.20040774 Perico L, Benigni A, Remuzzi G. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade. NEF. March 2020:1-9. doi:10.1159/000507305 Qiao Y, Shin J-I, Chen TK, et al. Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate. JAMA Intern Med. March 2020. doi:10.1001/jamainternmed.2020.0193 The Local. UPDATE - Coronavirus: French health minister and WHO issue warning over taking anti-inflammatories. https://www.thelocal.fr/20200314/coronavirus-french-health-minister-issues-warning-over-anti-flammatories. Published March 14, 2020. Accessed March 30, 2020. ScienceAlert. Updated: WHO Now Doesn’t Recommend Avoiding Ibuprofen For COVID-19 Symptoms. https://www.sciencealert.com/who-recommends-to-avoid-taking-ibuprofen-for-covid-19-symptoms. Accessed March 30, 2020. European Medicines Agency. Coronavirus disease (COVID-19). https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19#advice-on-using-non-steroidal-anti-inflammatory-medicines-such-as-ibuprofen--section. Published March 18, 2020. U.S. Food and Drug Administration. FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19. https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19. Published March 19, 2020. BBC Reality Check team and BBC Monitoring. Coronavirus and ibuprofen: Separating fact from fiction. BBC News. https://www.bbc.com/news/51929628. Published March 17, 2020. Mosbergen D. Tylenol Overdose Risk Is Staggering; Acetaminophen Safeguards Remain Insufficient: Report. HuffPost. https://www.huffpost.com/entry/tylenol-overdose_n_3976991. Published September 24, 2013.
Welcome to the COVID-ZONE. Journalspotting is here to bring you important clinical updates on coronavirus. Get in touch: journalspotting@gmail.com Twitter @JournalSpotting In today's episode: #ACE inhibitors and angiotensin receptor blockers- do they worsen COVID-19? https://doi.org/10.1016/j.cell.2020.02.052 ESC position statement #The NSAID controversy https://doi.org/10.1016/S2213-2600(20)30116-8 EMA statement French pharmacovigilance of ibuprofen MHRA alert Indomethacin and SARS CoV-1 #Lopinavir/Ritonavir falls at the first hurdle https://www.nejm.org/doi/pdf/10.1056/NEJMoa2001282?articleTools=true #Chloroquine/Hydroxychloroquine get a big endorsement Systematic review on the efficacy and safety of chloroquine for treatment of COVID-19 Letter in Bioscience trends 10.5582/bst.2020.01047 In vitro study of chloroquine: https://www.nature.com/articles/s41422-020-0282-0 #How good are the swabs? https://jamanetwork.com/journals/jama/fullarticle/2762997 #Anosmia is the new normal: Will I ever smell again? https://www.entnet.org/content/coronavirus-disease-2019-resources #Coronavirus likes plastic, hates pennies: which surfaces should I be wiping down? https://pubmed.ncbi.nlm.nih.gov/32182409/ #Modelling studies that matter https://www.bmj.com/content/bmj/368/bmj.m1216.full.pdf https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/ Oxford modelling #Covert COVID Distractions Because isolation can bring out a sense of humour in us, and we all need a distraction!
This episode was recorded on Monday, March 30, 2020.Claim credit here: https://ce.mayo.edu/covid19podcastGuest: Matthew P. Van Cuyk, Pharm.D., R.Ph. Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006) Should we be using ibuprofen to treat patients with COVID-19? Does this fall into the modifiable risk category? Dr. Matthew Van Cuyk breaks down recent events and literature around ibuprofen use in patients with COVID-19. Deeper Dive:Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The Lancet Respiratory Medicine. March 2020. https://doi.org/10.1016/S2213-2600(20)30116-8HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19ASHP Coronavirus Resource Center: https://www.ashp.org/Pharmacy-Practice/Resource-Centers/CoronavirusAssessment of Evidence for COVID-19-Related Treatments: Updated 3/27/2020For the most up to date COVID-19 information: CDC: https://www.cdc.gov/coronavirus/2019-ncov/index.htmlWHO: https://www.who.int/emergencies/diseases/novel-coronavirus-2019
For the 16 people out there that aren't sick of COVID-19/SARS-CoV-2 information already, here is another BONUS MINISODE on just that topic! This time around we're covering treatments that scientists and doctors around the world are trying to use to fight COVID-19. We discuss the WHO's new clinical trial to gather some data on these treatments, talk about 5 of the treatments more specifically, and then go into debunking mode! Useful links on the latest number of infected: https://covidtracking.com/us-daily/ https://coronavirus.jhu.edu/map.html References: https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments https://www.nytimes.com/2020/03/23/health/coronavirus-drugs-remdesivir.html https://www.reuters.com/article/us-health-coronavirus-gilead-sciences/gileads-potential-coronavirus-treatment-gets-fdas-orphan-drug-label-idUSKBN21A3PR https://www.jbc.org/content/early/2020/02/24/jbc.AC120.013056.full.pdf https://www.nature.com/articles/s41584-020-0372-x https://www.sciencedirect.com/science/article/pii/S0166354220301145?via%3Dihub http://www.mediterranee-infection.com/wp-content/uploads/2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_pdf/-char/en http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.03.03 https://www.ncbi.nlm.nih.gov/pubmed/12662125 https://www.nejm.org/doi/10.1056/NEJMoa2001282 https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds https://www.jci.org/articles/view/138003 https://www.latimes.com/science/story/2020-03-20/how-blood-from-people-who-survived-covid-19 https://www.thelancet.com/action/showPdf?pii=S2213-2600%2820%2930116-8
This episode is current up to Friday March 6. Guest Appearance: Dr. Joe Akin, PhD, Immunologist alumnus from Harvard Medical school, of https://refigure.org. Support this podcast! https://anchor.fm/chubbyemu/support Video version of this episode: https://youtu.be/b4zely3ofBk Please check out https://refigure.org: Save and organize journal figures in one-click. (not sponsored) Music by Lifeformed. Please check out his music at his Bandcamp: https://lifeformed.bandcamp.com Additional music inspired by Robert Prince Papers described in show: Clinical Course And Outcomes Of Critically Ill Patients With SARS-CoV-2 Pneumonia In Wuhan, China: a single-centered, retrospective, observational study. Lancet. https://doi.org/10.1016/S2213-2600(20)30079-5 Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal Of Medicine. https://doi.org/10.1056/NEJMoa2002032 Early Transmission Dynamics in Wuhan, China, Of Novel Coronavirus-Infected Pneumonia. New England Journal Of Medicine. https://doi.org/10.1056/NEJMoa2001316 A Novel Coronavirus from Patients With Pneumonia in China, 2019. New England Journal Of Medicine. https://doi.org/10.1056/NEJMoa2001017 Video by Chubbyemu: 3 COVID19 Cases As Described By Doctors In China: https://youtu.be/Q0A0LyMru3I --- Support this podcast: https://anchor.fm/chubbyemu/support
Le Pr Jean-Pierre Frat, qui est PUPH dans le service de MIR de l’Hôpital de Poitiers, nous parle son étude concernant la « VNI versus optiflow en pré-oxygénation d'une intubation orotrachéale pour une insuffisance respiratoire hypoxémique ».Aucun lien d’intérêt déclaré.Sommaire :• Pouvez-vous nous expliquer le contexte scientifique qui a justifié la réalisation de cette étude ?• Pouvez-vous nous décrire la population incluse et les principaux résultats de l’étude ?• Quelles sont d’après-vous les principales limites de cette étude ?• Cette étude doit-elle modifier notre pratique quotidienne, et si oui comment ?Références :Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trialFrat JP, Ricard JD, Quenot JP, Pichon N, Demoule A, Forel JM, Mira JP, Coudroy R, Berquier G, Voisin B, Colin G, Pons B, Danin PE, Devaquet J, Prat G, Clere-Jehl R, Petitpas F, Vivier E, Razazi K, Nay MA, Souday V, Dellamonica J, Argaud L, Ehrmann S, Gibelin A, Girault C, Andreu P, Vignon P, Dangers L, Ragot S, Thille AW; FLORALI-2 study group; REVA network.Lancet Respir Med. 2019 Apr;7(4):303-312. DOI : 10.1016/S2213-2600(19)30048-7.
Le Professeur Diehl aborde la BPCO en réanimation en détaillant la prise en charge ventilatoire et la place des nouvelles stratégies thérapeutiques (ECCO2R, Optiflow) Articles en lien : A Multicenter Randomized Trial Assessing the Efficacy of Helium/Oxygen in Severe Exacerbations of Chronic Obstructive Pulmonary Disease. Jolliet P, Ouanes-Besbes L, Abroug F, Ben Khelil J, Besbes M, Garnero A, Arnal JM, Daviaud F, Chiche JD, Lortat-Jacob B, Diehl JL, Lerolle N, Mercat A, Razazi K, Brun-Buisson C, Durand-Zaleski I, Texereau J, Brochard L; E.C.H.O. ICU Trial Investigators. Am J Respir Crit Care Med. 2017 Apr 1;195(7):871-880. doi: 10.1164/rccm.201601-0083OC. PMID: 27736154 Lancet Respir Med. 2018 Nov;6(11):874-884. doi: 10.1016/S2213-2600(18)30326-6. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Boyle AJ, Sklar MC, McNamee JJ, Brodie D, Slutsky AS, Brochard L, McAuley DF; International ECMO Network (ECMONet). Am Rev Respir Dis. 1987 Oct;136(4):872-9. The effects of ventilatory pattern on hyperinflation, airway pressures, and circulation in mechanical ventilation of patients with severe air-flow obstruction. Tuxen DV, Lane S.
Idag pratar jag lite om laktat, och hur jag ser på denna kanske missförstådda molekyl. Referenser: Garcia-Alvarez, M., Marik, P., & Bellomo, R. (2014). Sepsis-associated hyperlactatemia. Critical Care. https://doi.org/10.1186/s13054-014-0503-3 Garcia-Alvarez, M., Marik, P., & Bellomo, R. (2014). Stress hyperlactataemia: Present understanding and controversy. The Lancet Diabetes and Endocrinology. https://doi.org/10.1016/S2213-8587(13)70154-2 Tapia, P., Soto, D., Bruhn, A., […]
Ajánlott irodalom: Verstraete, S., Verbruggen, S. C., Hordijk, J. A., Vanhorebeek, I., Dulfer, K., Güiza, F., … Jacobs, A. (2019). Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit : a 2-year follow-up of the PEPaNIC international , randomised , controlled trial, 7(February), 141–153. https://doi.org/10.1016/S2213-2600(18)30334-5 Marik, P. E. (2014). Enteral nutrition in the critically ill: Myths and misconceptions. Critical Care Medicine, 42(4), 962–969. https://doi.org/10.1097/CCM.0000000000000051 Martinez, E. E., Ariagno, K., Arriola, A., Lara, K., & Mehta, N. M. (2015). Challenges to nutrition therapy in the pediatric critically ill obese patient. Nutrition in Clinical Practice, 30(3), 432–439. https://doi.org/10.1177/0884533615569887 Fitz-gibbon, S., Tomida, S., Chiu, B., Nguyen, L., Du, C., Miller, J. F., … Weinstock, G. M. (2014). The Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report from the NASPGHAN Pancreas Committee Maisam, 133(9), 2152–2160. https://doi.org/10.1038/jid.2013.21.Propionibacterium
Summary: In this episode our guest is Dr. Robert Dickson a Pulmonologist from the University of Michigan who studies the respiratory microbiome. We discuss how the lung microbiome differs in health, chronic illness and acute disease states like pneumonia, sepsis and ARDS. The lung microbiome has the ability to predict frequency of exacerbations and even severity and progression of certain lung diseases. We’ll explore all of this plus Dr. Dickson’s new paper published last month in Nature Microbiology, which had the surprise of finding gut bacteria in the lungs during critical illness. Please enjoy this wide ranging discussion Disclosures: Dr. Dickson did not report any disclosures. Clinical Pearls 1. The lungs are constantly bombarded by microbes and the largest host to microbe interface in the body where bacteria come within millimeters of the blood stream. 2. The lung microbiome is altered in both acute and chronic diseases 3. The lung microbiome is altered by antibiotics, corticosteroids, PPIs and probably lots of other things we are just beginning to discover. Links from the Show: Dr. Dickson’s latest article reporting gut bacteria in the lungs during critical illnesses. Dickson, R et al. Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nature Microbiology 1, Article number: 16113 (2016). doi:10.1038/nmicrobiol.2016.113 A link to Dr. Dickson’s podcast discussing the role of microbiome and the care and treatment of critically ill patients. The role of microbiome: The Lancet Respiratory Medicine: January 2016 Dr. Dickson’s recent publication in The Lancet. Robert Dickson. The microbiome and critical illness. The Lancet. Published Online: 11 December 2015. DOI: http://dx.doi.org/10.1016/S2213-2600(15)00427-0 Five clinical pearls on the Pulmonary microbiome Robert P. Dickson and Gary B. Huffnagle. The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease. PLoS Pathog. 2015 Jul; 11(7): e1004923. Published online 2015 Jul 9. doi: 10.1371/journal.ppat.1004923 PMCID: PMC4497592 A comprehensive review of the Pulmonary Microbiome field Dickson, RJ et al. The Microbiome and the Respiratory Tract. Annu Rev Physiol. 2016;78:481-504. doi: 10.1146/annurev-physiol-021115-105238. Epub 2015 Nov 2.
© 2020-2025 Ivy Podcast Discovery LLC
