Podcasts about Stratification

01:00 I Make It Hard For People To Get Close To Me, https://lukeford.net/blog/?p=165831 02:00 The Bondi Massacre Reveals The Moral & Intellectual Bankruptcy Of Australia's Jewish Leaders, https://lukeford.net/blog/?p=165455 07:00 Why America can't have nice things, https://www.youtube.com/watch?v=SMgoXdv5S84 10:00 The LAFD Didn't Put Out A Key Fire Because They Valued Plants More Than People, https://lukeford.net/blog/?p=165760 28:00 Claire Khaw joins to help me with my self-loathing 1:04:00 Michael joins, https://x.com/Michaelmvlog 1:06:00 The Lost Generation, https://www.compactmag.com/article/the-lost-generation/ 1:07:00 The Vanishing White Male Writer, https://www.compactmag.com/article/the-vanishing-white-male-writer/ 1:08:00 Are There Anti-Male, Anti-White Spaces? https://lukeford.net/blog/?p=165785 1:19:00 Conservatism's Long Con, https://thebaffler.com/salvos/the-long-con Status Closure and The Lost Generation, https://lukeford.net/blog/?p=165638 1:43:00 The Credential Society: An Historical Sociology of Education and Stratification, https://lukeford.net/blog/?p=165627 1:44:00 Credentialing Theory: What is Credential Inflation? 1:55:00 How Might AI Shift The Balance Of Power At Work? https://lukeford.net/blog/?p=165775 1:58:00 Credential creep, https://www.youtube.com/watch?v=Gu0DzTAo4uY 2:10:000 Status Closure and The Lost Generation, https://lukeford.net/blog/?p=165638 Experts Need More Power For Your Own Good, https://lukeford.net/blog/?p=165809 The Vanishing Jew by Jacob Savage, https://lukeford.net/blog/?p=165804 Why does Gemini capitalize Black and not White?, https://lukeford.net/blog/?p=165799 We Have Never Been Woke: The Cultural Contradictions of a New Elite, https://lukeford.net/blog/?p=165796 The Guild War: Why Credentials Won't Save the Incompetent Elite, https://lukeford.net/blog/?p=165765

Real talk for real Airmen. I drop blunt, battle-tested insight on leadership, excellence, discipline, and the warrior ethos. No fluff, no shortcuts, no easy bus. Just the truth, the standard, and how to rise above average. Charge into the storm & Stay hard to kill.Article here

Explore our new podcast with Dr. Grace Chua and Dr. Anil Maheshwari as they explore risk stratification, early detection tools, and smarter referral strategies to elevate cardiometabolic care. Part of the Obesity and CVD Knowledge Mobilization Strategy, this initiative equips providers with tools and evidence to address obesity as a key driver of cardiovascular disease.

In this episode, Michael welcomes Lightbeam Health CTO Mike Hoxter to discuss how advanced analytics and social determinants of health (SDOH) data are reshaping population health management. As organizations deepen their commitment to value-based care, Mike explains how modern risk stratification tools help identify at-risk populations earlier, reduce avoidable costs, and drive more equitable, proactive care. With real-world examples and practical insights, this conversation offers a clear look at what's working—and what's next—in population health innovation.

Dr Neil Greening and Dr Hnin Aung join Diana Stanley to discuss a new multidimensional prognostic risk stratification model for COPD exacerbations.click here to read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00362-5/fulltextContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Welcome back to the tasty morsels of critical care podcast. I haven't managed to cover PE on the podcast yet. I have been involved in lots of small PE projects over the years and have developed something of an interest ... Read More »

Dr. Emile Daoud, Deputy Editor of JACC Clinical Electrophysiology, discusses Risk Stratification in LBBB after TAVI: Comparison Between a Novel ECG Algorithm and ESC Criteria.

Dr. Emile Daoud, Deputy Editor of JACC Clinical Electrophysiology discusses Risk Stratification in LBBB after TAVI: Comparison Between a Novel ECG Algorithm and ESC Criteria.

Join host Alex Crespo, MD as he chats with author Michael Weaver, MD about the Journal of Orthopaedic Trauma article on the Frailty Index as a possible stratification tool in the CMS hip fracture bundle. To access the abstract, click here. For additional educational resources visit OTA.org

Could ongoing trials redefine the management of oligometastatic and advanced prostate cancer? In this installment of BackTable Tumor Board, leading prostate cancer experts Dr. Neeraj Agarwal, a medical oncologist from the University of Utah, and Dr. Tyler Seibert, a radiation oncologist from UC San Diego, join host Dr. Parth Modi to share their insights on the latest clinical trials and persistent challenges in managing prostate cancer.---This podcast is supported by:Ferring Pharmaceuticals https://ad.doubleclick.net/ddm/trackclk/N2165306.5658203BACKTABLE/B33008413.420220578;dc_trk_aid=612466359;dc_trk_cid=234162109;dc_lat=;dc_rdid=;tag_for_child_directed_treatment=;tfua=;gdpr=${GDPR};gdpr_consent=${GDPR_CONSENT_755};gpp=${GPP_STRING_755};gpp_sid=${GPP_SID};ltd=;dc_tdv=1---SYNPOSISThe multidisciplinary discussion addresses clinical decision-making in active surveillance versus early intervention, the role of PSMA PET imaging in detection and treatment planning, and evolving strategies for metastatic and castration-resistant disease. They also evaluate the therapeutic potential of alpha emitters and radioligand therapies, consider the evidence behind treatment intensification and de-intensification, and explore how these approaches can be individualized to optimize patient outcomes.---TIMESTAMPS0:00 - Introduction1:48 - Active Surveillance in Low-Risk Prostate Cancer7:08 - Molecular Testing and Risk Stratification8:28 - Radiation Therapy Approaches20:16 - PSA Recurrence and PSMA PET Scans32:40 - The Role of ADT37:15 - PSMA PET Scans40:58 - Genetic Testing in High-Risk and Metastatic Prostate Cancer46:54 - Treatment Intensification vs. De-Intensification Trials55:59 - Castration-Resistant Prostate Cancer

In this week's episode, host Paul Wirkus, MD, FAAP, and guests Kristi Glotzbach, MD, and Laura Wood, PhD discuss recommendations for recognizing and addressing neurodevelopmental risks in infants and children with congenital heart disease (CHD). Listen in as they review strategies for risk identification, protection, screening, and evaluation, and focus on how clinicians can stratify risk for neurodevelopmental challenges in this vulnerable population. Have a question? Email questions@vcurb.com. Your questions will be answered in week four.For more information about available credit, visit vCurb.com.ACCME Accreditation StatementThis activity has been planned and implemented in accordance with the accreditation requirements and policies of the Colorado Medical Society through the joint providership of Kansas Chapter, American Academy of Pediatrics and Utah Chapter, AAP.  Kansas Chapter, American Academy of Pediatrics is accredited by the Colorado Medical Society to provide continuing medical education for physicians. AMA Credit Designation StatementKansas Chapter, American Academy of Pediatrics designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Back after a long break, Caasim, Celeste, Dev, and Upo get a little stupid. Bevs were flowing so apologies for the peaks in this episode. Enjoy!

CME credits: 0.75 Valid until: 22-08-2026 Claim your CME credit at https://reachmd.com/programs/cme/risk-stratification-and-patient-selection-for-perioperative-icis/36633/ This online CME activity examines advances in managing resectable locally advanced head and neck squamous cell carcinoma (HNSCC), focusing on the integration of perioperative immune checkpoint inhibitors (ICIs) and multimodal approaches. Faculty review current standards of care and highlight unmet needs that have driven investigation into combining radiation and immunotherapy. Emerging clinical trial data are discussed, including the impact of perioperative ICIs on event-free survival and pathologic response, with attention to patient selection informed by risk stratification and biomarkers. The program also addresses practical considerations for multidisciplinary care, including immune-related adverse event management and strategies to support patient access to these evolving treatment paradigms.

CME credits: 0.75 Valid until: 22-08-2026 Claim your CME credit at https://reachmd.com/programs/cme/risk-stratification-and-patient-selection-for-perioperative-icis/36633/ This online CME activity examines advances in managing resectable locally advanced head and neck squamous cell carcinoma (HNSCC), focusing on the integration of perioperative immune checkpoint inhibitors (ICIs) and multimodal approaches. Faculty review current standards of care and highlight unmet needs that have driven investigation into combining radiation and immunotherapy. Emerging clinical trial data are discussed, including the impact of perioperative ICIs on event-free survival and pathologic response, with attention to patient selection informed by risk stratification and biomarkers. The program also addresses practical considerations for multidisciplinary care, including immune-related adverse event management and strategies to support patient access to these evolving treatment paradigms.

Dr. Robert Frantz breaks down the key metrics behind risk stratification—functional class, six-minute walk distance, and brain natriuretic peptide levels—and explains how they shape treatment plans. He also explores the role of echocardiography, right heart catheterization, and cutting-edge therapies in improving patient outcomes. Read the proceedings of the Task Force on Risk Stratification from the Seventh World Symposium on Pulmonary Hypertension.  This Special Edition Episode Sponsored by: Johnson & Johnson Learn more about pulmonary hypertension trials at www.phaware.global/clinicaltrials. Follow us on social @phaware Engage for a cure: www.phaware.global/donate #phaware Share your story: info@phaware.com #phawareMD #RiskStratification @MayoClinic @MayoMedEd @TeamPHHope @JNJInnovMed

In this episode of Tech it to the Limit, Dr. Rachel Harrington (NCQA) joins hosts Sarah Harper and Elliott Wilson to unpack how digital tools are reshaping healthcare—and why equity must be part of the equation. From fixing biased data to evolving HEDIS and designing with communities, it's a sharp look at the future of human-centered, tech-powered care.Key TakeawaysStart with the right data: If we don't ask the right questions and reflect real diversity, we're guessing, not solving.Co-create with communities: Don't design for people—design with them to build solutions that actually work.Go beyond broad stats: Break down the data to see what different groups really need.Tackle the root causes: Health isn't just about doctors—it's about housing, food, transport, and more.Act, don't just assess: Finding problems is easy. Solving them takes real action.In this episode:[00:00:00] Welcome to Tech it to the Limit[00:01:43] Insights from the Mayo Clinic AI Summit[00:04:05] Segment spotlight – “Guess That Quality Data Acronym”: [00:11:05] Conversation with Dr. Rachel Harrington, NCQA: advancing equity through data and measurement[00:26:15] Collaborating across sectors: the importance of community-based partnerships[00:27:12] Stratification and the role of data transparency in identifying quality gaps[00:27:44] Transitioning to HEDIS: why equity must be embedded in quality measurement[00:29:15] The impact of race and ethnicity stratification in performance metrics[00:32:13] Aligning incentives across payers, providers, and systems for greater accountability[00:39:12] Designing for equity: avoiding bias in digital health tools through inclusive development[00:42:57] A call to action: how digital health leaders can make equity core to their strategy[00:46:02] Final reflections and key insightsOur GuestDr. Rachel Harrington is the Assistant Vice President of Health Equity at the NCQA, where she leads the Equity and HEDIS initiative. With a Ph.D. in pharmacy systems and a background in regulatory science, health economics, and public policy, Rachel has a wealth of experience in healthcare data, quality improvement, and social determinants of health. Her work ensures that healthcare systems deliver equitable, effective care for all communities.ResourcesDr. Rachel HarringtonNCQADr. Rachel HarringtonWe Ask Because We Care campaignTech It To The Limit PodcastWebsite Apple Podcast

Osteosarcoma Webinar Series: Amanda Marinoff, MD, a physician-scientist from UCSF will discuss clinical biomarkers for osteosarcoma stratification (cBOSS): Insights from a working group.Despite decades of research, osteosarcoma remains one of the few pediatric cancers without validated molecular biomarkers to guide treatment. The Clinical Biomarkers for Osteosarcoma Stratification (cBOSS) initiative is an international effort to change that. Modeled after a successful framework in Ewing sarcoma, cBOSS convened experts from North America and Europe to systematically evaluate emerging molecular features with the greatest potential for near-term clinical translation. Through a series of structured sessions, the group assessed the biological plausibility, clinical relevance, and implementation feasibility of candidate classifiers across five domains: genomic, transcriptomic, epigenetic, immune, and circulating analytes. This webinar will provide an overview of the cBOSS approach, key findings to date, including the maturity of circulating tumor DNA and MYC amplification as prognostic tools, and the path forward for incorporating molecular stratification into future clinical trials. The goal: to move beyond one-size-fits-all therapy and build a precision medicine framework for osteosarcoma.Dr. Amanda Marinoff is a pediatric oncologist and translational researcher at UCSF, where she focuses on developing molecular biomarkers to improve risk stratification and treatment for children and young adults with osteosarcoma. She co-leads the international cBOSS initiative (Clinical Biomarkers for Osteosarcoma Stratification), which brings together experts across North America and Europe to evaluate and prioritize emerging classifiers for clinical use. Her research aims to bridge the gap between genomic discovery and therapeutic application, advancing precision medicine approaches for patients with high-risk disease. Dr. Marinoff earned her medical degree from Harvard Medical School, completed her pediatrics residency at Boston Children's Hospital, and completed her pediatric hematology/oncology fellowship at UCSF Benioff Children's Hospital. She is an active member of the pediatric solid tumor and early-phase clinical trials groups at UCSF.

Get access to The Backroom (70+ exclusive episodes) on Patreon:https://www.patreon.com/OneDimeIs the Marxist conception of class outdated? In this episode of 1Dime Radio, I'm joined by Dave from Theory Underground to unpack the “Post-Class Fractured Mass” (PCFM): why the working class, the “proletariat”  no longer coheres the way Marxists imagined, how media + schooling carve us into niches and swarms, and what this means for organizing today. We talk about why the decline of working-class power is due to real material factors in the economy, and not just due to ideology and “class consciousness.”  This brings us to the pivotal question: in the age of the gig economy, is the working class obsolete as the agent of revolutionary change? If so, who is the revolutionary subject today? In the backroom, we discuss the issues with the term “Post-Left”, how people burn out from politics, and how bourgeois pseudoprogressive libertine attitudes bleed into leftist circles (like polyamory, non-monogamy, etc). Become a patron at Patreon.com/OneDime if you haven't already!Timestamps: 00:00:00 The Backroom Preview05:15  The Post-Class Fractured Mass (PCFM)  07:08 Jobs, Careers, & Time-energy 10:33 “Progressive” schooling as sorting/gatekeeping  25:54 From Class Power to Popular Front of "The Vulnerable"30:14 Outsourcing, deindustrialization & Stratification  36:35  The “Dictatorship of the Proletariat”  42:27 Can the Democratic Party be “reformed”?  50:10 The Gig Economy and The Breakdown of Solidarity 01:02:08  Ideological Gerrymandering01:21:45 AI & Transition to The Backroom GUEST:Dave — Theory Underground• Check out the Theory Underground YouTube Channel: https://www.youtube.com/@theory_underground• Check out the Underground Theory Book (Im in it too!) : https://www.amazon.com/Underground-Theory-David-McKerracher/dp/B0CH2CXSGN• Check out the Dave's Timenergy Book: https://www.amazon.com/Timenergy-Why-Have-Time-Energy/dp/B0D285C1TV/ref=sr_1_1?dib=eyJ2IjoiMSJ9.uWMeog7v0Fzxa2o7vYK7_OuDzbW0mXjpYddGDa84LDHzaHN7WUeL3O_T1zrzPCEr4Tw75Pn1KD82Jmmdem3hjQKq0TW4WLFIA3DIhDNVaV4.mgTh5f1Lm2lcEPI24AzA_GwBr-Gs5nOCIyzU_5-BfEg&dib_tag=se&qid=1753806927&refinements=p_27%3ADavid+McKerracher&s=books&sr=1-1&text=David+McKerracherFOLLOW 1Dime:• X/Twitter: https://x.com/1DimeOfficial •  Follow me on Instagram: instagram.com/1dimeman •Check out my main channel videos: https://www.youtube.com/@1Dimee Outro Music by Karl CaseyGive the Podcast a 5-star Rating if you enjoyed the show!

Early detection of oesophageal adenocarcinoma improves outcomes. Patients with the precursor lesion, Barrett's oesophagus, are recommended to undergo regular endoscopic surveillance, a process that can be burdensome for patients and health services. Professor Rebecca Fitzgerald's team have developed a tool that may be able to improve Barrett's surveillance. She joins us to discuss her recent prospective real-world implementation study of capsule sponge risk stratification in Barrett's oesophagus surveillance in the UK.Read the full article:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01021-9/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

If you're a fan of fans, this is the podcast for you! In this short podcast episode, Bryan shares how installing ceiling fans can be a smart HVAC design strategy (even though he wasn't a fan of fans!). Ceiling fans break the "don't blow air on people" rule we usually refer to in duct design, but they can solve quite a few basic comfort problems, especially in homes with lower loads than we've historically seen. They're great for creating high-velocity airstreams and mixing air. Low-load homes have systems with lower tonnages; they don't move as much air and could use a little bit of help from a ceiling fan. Air mixing is also poor in homes that have a greater distance between the air and the ceiling. Stratification of the air causes comfort problems due to temperature differences, and hot or cold surfaces can also contribute to these issues for similar reasons. Moisture and eventual growth are also concerns when we allow rooms to have those temperature differences (especially on the ceiling, as water vapor is lighter than air). Ceiling fans disrupt the stratification of air and water vapor. They solve air mixing problems while they dispel odors and maintain more consistent dew points throughout the air. Modern fans with ECMs can also run at a low speed without taking a large energy efficiency hit. Ceiling fans are great and relatively inexpensive solutions that can solve comfort and IAQ problems in high-performance homes.   Have a question that you want us to answer on the podcast? Submit your questions at https://www.speakpipe.com/hvacschool. Purchase your tickets or learn more about the 7th Annual HVACR Training Symposium at https://hvacrschool.com/symposium. Subscribe to our podcast on your iPhone or Android. Subscribe to our YouTube channel. Check out our handy calculators here or on the HVAC School Mobile App for Apple and Android

Dr. Wenqing Li joins Peng Zhang to discuss a recent study integrating genetics and transcriptomics for risk stratification of gastric cancer. The conversation explores the global epidemiology of gastric cancer, its high prevalence and mortality rates, particularly in East Asia and China, and the complex interplay of genetic and environmental risk factors, notably Helicobacter pylori infection.Read the full article:https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00211-7/fulltext?dgcid=buzzsprout_icw_podcast_July_25_ebiomContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

July 3, 2025: Alan Smith, SVP and CIO of Lifepoint Health, joins Bill for a discussion on the top challenges facing CIOs. How do you balance immediate system stability when your organization is built through constant acquisitions? Al discusses his approach to the "CIO escape room" scenarios that define modern healthcare IT, from major partner outages to the ongoing tension between cloud-first strategies and financial realities. As healthcare organizations grapple with cost pressures while demanding more from their IT departments, Alan reveals how LifePoint navigates these competing forces and what it takes to build resilient systems in an industry where failure isn't an option. Key Points: 04:57 CIO Escape Room 14:14 The Importance of Inquisitiveness 17:31 Strategies in Virtual Leadership 26:12 Advice for Future Healthcare IT Leaders X: This Week Health LinkedIn: This Week Health Donate: Alex's Lemonade Stand: Foundation for Childhood Cancer

In this week's episode, we'll learn more about social determinants of health that impact access to allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia, or AML; use of megakaryocyte growth factor receptor-based stem cell depletion as part of pretransplant conditioning in ex vivo autologous gene therapy; and identification of an eight-protein risk signature as well as a novel single protein biomarker, soluble oncostatin M receptor, for risk stratification in AML.Featured Articles:Social Determinants of Health and Access to Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid LeukemiacMPL-Based Purification and Depletion of Human Hematopoietic Stem Cells: Implications for Pretransplant ConditioningBlood-Based Proteomic Profiling Identifies OSMR as a Novel Biomarker of AML Outcomes

Dan, Manny, & Billy invite friend & fan of the pod Meghan P. Nolan to put the 1985 action/adventure comedy The Goonies to the ultimate test—THE NOSTALGIA TEST! “I had this epiphany while I was watching it this time where I was like, ‘Holy shit! Like Goonies are just like a bunch of nerds, they're all just sitting around playing D&D, Mikey is the dungeon master, and this is their quest.” -Meghan P. Nolan Around 2 years ago, Meghan sent us a suggestion to put The Goonies to the ultimate test and because Dan is super lazy it took him this long to get her on the pod. This episode is off the rails from the start filled with classic Nostalgia Test drops and a live Zoom audience of one, (haha! it's a start) Courtney from the Fiction Fixation Podcast who added some hilarious ideas while Billy dealt with his North Carolina internet service. The gang talks about “Goonies” comes from their town name The Goon Docks, what did the parents of these kids do to get all their houses foreclosed on, why was Troy and his flunkies hanging around a wishing well, are the Fratellis really Italian, and who was resetting One Eyed Willie's booby traps in the 1600s. They also analyze all the amazing characters, unpack the stereotypes, plot holes, and put Cindy Lauper's song to a quick Nostalgia Test. Most importantly, they talk about the real heroes of this movie Rosalita and Sloth. This episode is what The Nostalgia Test is all about, laughter, hot takes, and a bunch of hypothetical scenarios for what a Goonies sequel or TV series might look like. This is a must-listen for any fan of 80s classics. Email us (thenostalgiatest@gmail.com) your thoughts, opinions, and questions about this episode or anything else nostalgic on your mind and we'll read it for next time on the pod!   APPROXIMATE RUN OF SHOW: 00:00 Introduction to the Nostalgia Test Podcast 00:45 Welcoming the Hosts and Guest 01:15 Discussing The Goonies and Nostalgia 02:10 The Goonies' Cultural Impact 04:08 Analyzing Characters and Stereotypes 10:07 Plot Holes and Funny Observations 15:47 The Goonies' Opening Scene and PG Rating 26:51 Music and Product Placement in The Goonies 30:41 Kids' Reactions to The Goonies 31:36 Comparing The Goonies to Other 80s Movies 33:35 Modern Movie Music and Final Thoughts 36:06 Revisiting 'The Goonies': Childhood Memories and Cable TV 37:03 Tree Climbing Adventures and Childhood Mischief 38:24 The Goonies' Treasure Hunt Begins 39:03 Decoding the Pirate Map and Family Dynamics 40:27 The Goonies' Quest: Booby Traps and Town Secrets 42:19 Character Dynamics and 80s Stereotypes 50:14 The Fratelli Family: Villains or Victims? 52:21 Sloth: The Unlikely Hero 56:21 The Goonies' Final Adventure: Treasure and Triumph 01:10:35 Nostalgic Jail Cell Memories 01:11:02 The Idiot Mob in Astoria 01:11:42 Chunk's Hilarious Car Encounter 01:12:22 Goonies Theme Park and Escape Room Ideas 01:14:21 Mikey's Iconic Speech 01:16:02 Speculating on the Goonies Sequel 01:22:25 The Goonies' Legacy and Trivia 01:34:56 Final Thoughts and Nostalgia Test   Meghan P. Nolan, MFA, MA, PhD, is an Associate Professor of English and Chair of the Honors program at State University of New York, Rockland. She is a recipient of the SUNY Chancellor's Award for Excellence in Teaching. She is a multi-genre writer, who focuses on(Neo-)Victorian and Modern literature/ crime writing and fragmented perceptions of self-hood through academic works, fiction, non-fiction, and poetry. Her book The Crossroads of Crime Writing: Unseen Structures and Uncertain Spaces was published by Anthem Press (March 2024). She is the author of the poetry collection, Stratification (2008) and her poems have been in many literary journals over the years. Recently, her works have been on public display as a part of the “Writing on the Walls” exhibits at the Hudson Valley Museum of Contemporary Art (HVMOCA) and she regularly performs her poetry and monologues as a part of productions by both Studio Theater in Exile and Tutti Bravi respectively. Her works have appeared in Approaches to Teaching the Works of Fernando Pessoa (2025), Mean Streets (2021), Persona Studies (2021 and 2015), Transnational Crime Fiction: Mobility, Borders, and Detection (2020), Exquisite Corpse: Studio Art-Based Writing in the Academy (2019), The 100 Greatest Detectives (2018), and Thread (2017). For more info visit mpnolan.com.  Order Meghan's book The Crossroads of Crime Writing: Unseen Structures and Uncertain Spaces at Barnes & Nobel & Amazon   Book The Nostalgia Test Podcast Bring The Nostalgia Test Podcast's high energy fun and comedy on your podcast, to host your themed parties & special events!  The Nostalgia Test Podcast will create an unforgettable Nostalgic experience for any occasion because we are the party! We are the most dedicated guests! We bring it 100% of the time! Email us at thenostalgiatest@gmail.com or fill out the form at this link. LET'S GET NOSTALGIC!     Keep up with all things The Nostalgia Test Podcast on Instagram | Substack | Discord | TikTok | Bluesky | YouTube | Facebook   The intro and outro music ('Neon Attack 80s') is by Emanmusic. The Lithology Brewing ad music ("Red, White, Black, & Blue") is by PEG and the Rejected

Ponds can naturally separate with warm oxygenated water near the surface and a cooler, unoxygenated layer in deeper areas. Join Joe and Drew as they discuss pond stratification, summer fish kills, and how aeration may help maintain a thriving pond ecosystem. Dr. Joe Gerken and Dr. Drew Ricketts are extension specialists and faculty members in the Wildlife and Outdoor Enterprise Management Program at Kansas State university. Find out more about the program at http://hnr.k-state.edu/academics/undergraduate-programs/wildlife-outdoor-management.html

Ponds can naturally separate with warm oxygenated water near the surface and a cooler, unoxygenated layer in deeper areas. Join Joe and Drew as they discuss pond stratification, summer fish kills, and how aeration may help maintain a thriving pond ecosystem. Dr. Joe Gerken and Dr. Drew Ricketts are extension specialists and faculty members in the Wildlife and Outdoor Enterprise Management Program at Kansas State university. Find out more about the program at http://hnr.k-state.edu/academics/undergraduate-programs/wildlife-outdoor-management.html

Darrick Hamilton, director of the Institute for the Study of Race, Stratification, and Political Economy at the New School talks about Trump's Platinum Plan and whether it was a bait and switch move on Black America. Become a supporter of this podcast: https://www.spreaker.com/podcast/tavis-smiley--6286410/support.

The JournalFeed podcast for the week of April 21-25, 2025.These are summaries from just 2 of the 5 articles we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Wednesday Spoon Feed:This preplanned subgroup analysis of the TOMAHAWK Trial of patients with ROSC after OHCA found no EKG findings (excluding STEMI) that predicted the presence of coronary artery lesions.Thursday Spoon Feed:In this substudy of the Canadian TIA Score cohort, researchers found score utilization with subsequent MRI imaging could improve the outcome of patients suffering from TIA or stroke, particularly in the medium-risk category, scoring between 4-8 points.

Commentary by Dr. Xinxin Zhang.

How do you predict which intermediate-risk patients will suddenly deteriorate? What role do risk scores, biomarkers, imaging, and hemodynamics play in decision-making? Should these patients receive anticoagulation alone, or is thrombolysis warranted? When should you consider catheter-directed or surgical interventions? This podcast focuses us to think critically about risk stratification, early interventions and escalation in care in PE. We include an algorithm in the show notes. Not all patients fit neatly into classification boxes, making clinical judgment crucial. Join Dr. Lauren Westafer, Dr. Justin Morgenstern, Dr. Bourke Tillman and Anton as they explore the key decision points, pitfalls, and lifesaving strategies for managing intermediate-risk PE in the ED...

Today's podcast features a discussion with experts Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, and Ashutosh Wechalekar,... The post Post-ASH amyloidosis highlights: the ANDROMEDA trial, risk stratification, value of MRD, & more! appeared first on VJHemOnc.

Every civilization is shaped by its ruling elite, but what happens when those planning your society cannot understand the average person? Authors Charles Murray and Christopher Lasch have both discussed the dangers of cognitive stratification and how it could destroy social fabric. We will be discussing how that problem recently manifested itself in the debate over immigration and employment. Follow on: Apple: https://podcasts.apple.com/us/podcast/the-auron-macintyre-show/id1657770114 Spotify: https://open.spotify.com/show/3S6z4LBs8Fi7COupy7YYuM?si=4d9662cb34d148af Substack: https://auronmacintyre.substack.com/ Twitter: https://twitter.com/AuronMacintyre Gab: https://gab.com/AuronMacIntyre YouTube:https://www.youtube.com/c/AuronMacIntyre Rumble: https://rumble.com/c/c-390155 Odysee: https://odysee.com/@AuronMacIntyre:f Instagram: https://www.instagram.com/auronmacintyre/ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this podcast, Dr. Valentin Fuster discusses a groundbreaking study on using artificial intelligence (AI) in electrocardiograms (ECGs) to assess left ventricular diastolic function and predict outcomes in patients with significant mitral regurgitation. The study demonstrates that AI-driven ECGs can offer comparable prognostic value to traditional echocardiography, identifying high-risk patients and potentially revolutionizing cardiovascular diagnostics, though challenges around sensitivity, specificity, and patient selection remain.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on coronary artery calcium for risk stratification among persons with very high HDL cholesterol.

On this episode of the Strip-Till Farmer podcast, brought to you by Yetter, University of Illinois soil scientist Andrew Margenot shares key takeaways from his long-term phosphorous (P) studies. Margenot's research group focuses on everything from NPK recommended rates, soil test values, removal rates and more. He's currently leading the charge on a project to analyze thousands of soil samples dating back to the late 1800s — the largest soil samples archive in the world.

Darrick Hamilton, director of the Institute for the Study of Race, Stratification, and Political Economy at the New School, gives a deep-dive analysis into the competing economic plans in this year's presidential election and an update on the state of our economy.

In this week's episode we'll learn about refining risk stratification in T-cell acute lymphoblastic leukemia, or ALL. After that, we'll discuss a novel gene therapy approach in severe alpha-thalassemia. Investigators describe an innovative mouse model and an effective gene therapy approach, renewing prospects for the development of novel strategies to treat this disease. Finally, we'll hear about how genomic profiling has helped identify subgroups associated with distinct clinical phenotypes and outcomes in the molecular taxonomy of myelodysplastic syndromes, or MDS. Featured Articles NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup ofpatientsUse of HSC-targeted LNP to generate a mouse model of lethal α-thalassemia and treatment via lentiviralgene therapyMolecular taxonomy of myelodysplastic syndromes and its clinical implications

In this episode, Dr. Valentin Fuster discusses a groundbreaking study that evaluates the role of myocardial fibrosis in predicting sudden cardiac death and ventricular arrhythmias in patients with non-ischemic cardiomyopathy. The findings suggest that assessing fibrosis through advanced imaging techniques offers a more accurate risk stratification than the traditional reliance on left ventricular ejection fraction, ultimately refining treatment approaches for at-risk patients.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on mortality risk stratification utilizing artificial intelligence electrocardiogram for hyperkalemia in cardiac ICU Patients.

In this week's episode, we discuss the diagnostic criteria and risk stratification for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), building on our discussion from last week. Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!Episode contents: - A review of what to look at on the bone marrow biopsy report - WHO and ICC classification for AML and MDS - Disease-defining cytogenetic markers to be aware of and their prognostic implications ****Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this episode, we delve into the world of social protection with one of its foremost experts, Professor Armando Barrientos, Emeritus Professor of Poverty and Social Justice at the Global Development Institute, University of Manchester. We discuss his groundbreaking new book, Social Protection in Latin America, and explore the argument that social protection systems or institutions are not just safety nets but also mechanisms of stratification. We also talked about what that means, why it matters, and how it shapes the lives of millions across the region. Finally, we also examine the crucial role of politics in shaping social protection and debate whether Latin America should aspire to the European model of a welfare state. From the Latin American innovative approaches to their global influence and the future of social protection, this episode is a must-listen for anyone interested in the intersection of social justice and public policy.   Episode resources: Book | Social Protection in Latin America. Causality, Stratification and Outcomes Task Force | Global Alliance against Poverty and Hunger Publication | The relationship between cash-based interventions and violence: A systematic review and evidence map

durée : 00:45:09 - La 20e heure - par : Eva Bester - Eva Jospin, l'artiste aux forêts immenses ciselées minutieusement dans du carton, décline son travail de la sculpture à la broderie et présente une chambre à soi en soie dans l'orangerie du Château de Versailles, et son univers sylvestre au Museo Fortuny, dans le cadre de la Biennale de Venise.

We over-admit low risk acute heart failure patients and under-admit high risk heart failure patients. In this podcast we discuss the diagnostic accuracy of various clinical features, lab tests and imaging modalities for acute heart failure, the 3 validated risk stratification tools and a simple approach to PoCUS for the diagnosis and prognostication of acute heart failure in the ED to improve our diagnostic accuracy and disposition decisions for patients with acute heart failure...

Audio Commentary by Dr. Valentin Fuster, Emeritus Editor in Chief

Listen to hear our expert panel discuss risk stratification beyond the current guidelines. Topics include normotensive shock, a perspective from radiology, the NEWS Score, and VTI. Faculty discuss interesting cases and address challenging questions regarding how to risk stratify.

Dr. Neeraj Agarwal and Dr. Rana McKay discuss promising studies in GU cancers featured at the 2024 ASCO Annual Meeting that highlighted improved outcomes in urothelial carcinoma, improved survival in renal cell carcinoma, and the role of ctDNA as a potential biomarker for predicting outcomes.   TRANSCRIPT Dr. Neeraj Agarwal: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Neeraj Agarwal, your guest host of the ASCO Daily News Podcast today. I am the director of the Genitourinary Oncology Program, a professor of medicine at the University of Utah's Huntsman Cancer Institute, and editor-in-chief of the ASCO Daily News.  I am delighted to welcome Dr. Rana McKay, a GU medical oncologist and associate professor at the University of California San Diego. Today, we'll be discussing some key GU abstracts featured at the 2024 ASCO Annual Meeting. Our full disclosures are available in the transcript of this episode. Rana, we're thrilled to have you on the podcast today to share your insights on key advances in GU oncology from ASCO24. Dr. Rana McKay: Thank you so much, Neeraj; it's a pleasure to be here. Dr. Neeraj Agarwal: So, Rana, let's start with some bladder cancer abstracts. Could you tell us about Abstract 4503, titled “Impact of exposure on outcomes with enfortumab vedotin in patients with locally advanced or metastatic urothelial cancer”? Dr. Rana McKay: Of course, I would be delighted to. First, I would like to remind our listeners that enfortumab vedotin (EV) was approved as a monotherapy for the treatment of locally advanced or metastatic urothelial cancer based on the results of EV-201 and EV-301 trials. In these pivotal studies, EV was initiated at a dose of 1.25 mg/kg, and dose modifications, such as reductions and interruptions, were used to manage adverse events. In the abstract presented at ASCO 2024, Dr. Daniel Petrylak and colleagues conducted a post-hoc exploratory analysis to evaluate the association between EV plasma exposure and outcomes. They used multiple pharmacokinetic samples collected during the first two cycles and pre-dose samples from 3 EV monotherapy studies, namely EV-101, EV-201, and EV-301, that were conducted in patients with previously treated locally advanced or metastatic urothelial carcinoma. Dose reductions to 1 mg/kg were required in 42.1% and 35.1% of patients in the EV-201 and EV-301 trials, respectively, and reductions to 0.75 mg/kg were required in 13.6% and 11.1% in the EV-201 and EV-301 trials, respectively. Higher EV exposure during the first two cycles was associated with a higher objective response rate. The ORR was 21.4% for the dose of 0.75 mg/kg, while it was 18.5% for the dose of 1.0 mg/kg. Interestingly, increasing the dosage to 1.25 mg/kg improved the ORR, which ranged from 40 to 51.1% across various studies. In the EV-301 trial, when comparing the efficacy of EV to chemotherapy, EV improved PFS and OS across all dose quartiles, and there was no evidence that recommended dose modifications impacted long-term efficacy outcomes. Dr. Neeraj Agarwal: Thank you, Rana, for this great summary. I would like to add that the meticulously conducted pharmacokinetic studies demonstrated that serum levels of EV correlated with responses. Importantly, patients who had to decrease the dose did not experience compromised outcomes as EV improved PFS and OS outcomes vs chemotherapy in across all exposure quartiles in the EV-301 trial where EV was compared with chemotherapy. These findings highlight the need to start at the recommended dose of 1.25 mg/kg and reduce it, if necessary, however, clinicians should not start at a lower dose.  Dr. Rana McKay: I totally agree with you, Neeraj. Now, moving on to a different setting in bladder cancer, what can you tell us about LBA4517, titled “Perioperative sacituzumab govitecan alone or in combination with pembrolizumab for patients with muscle-invasive urothelial bladder cancer: SURE-01/02 interim results”? Dr. Neeraj Agarwal: Of course! So, SURE was a multicohort, open-label, phase 2 study in patients with muscle-invasive bladder cancer assessing sacituzumab govitecan as a neoadjuvant therapy either alone in SURE-01 or as a combination with pembrolizumab followed by adjuvant pembro in SURE-02 in a flexible design allowing a bladder-sparing approach. In the abstract presented at ASCO 2024, Dr. Antonio Cigliola and colleagues report interim results of the SURE-01 study. Patients with cT2-4N0M0 urothelial carcinoma who were ineligible for or refused cisplatin-based neoadjuvant chemotherapy were planned to receive 4 cycles of neoadjuvant sacituzumab govitecan at a dose of 10 mg/kg followed by radical cystectomy.  An extensive assessment was performed at baseline and after the 4 cycles for response assessment. Patients with clinical complete response defined with negative MRI, cystoscopy and ctDNA assays refusing radical cystectomy were offered redo transurethral resection of the bladder tumor or repeat TURBT followed by observation in the absence of viable high-grade tumor in the bladder. The primary endpoint was pathological complete response rate, while secondary endpoints included pathological downstaging rate and safety. After the first 8 patients were enrolled, the protocol was amended due to the occurrence of grade 3 and 4 neutropenia and diarrhea in 75% and 50% of patients, respectively, and 2 deaths – one of which was deemed to be treatment-related due to sepsis. Key protocol changes included the reduction of the dose of sacituzumab govitecan to 7.5 mg/kg, the introduction of G-CSF as primary prophylaxis, and the exclusion of patients at high risk of febrile neutropenia per ASCO guidelines.  Among 21 patients who received at least one cycle of sacituzumab govitecan and included in the intention-to-treat population, 47.6% had a complete pathological response, and 52.4% had pathological downstaging. 11 patients underwent radical cystectomy, while 7 received repeat-TURBT due to complete clinical response or patient preference. Regarding the safety profile, grade 3 or more adverse events occurred in 42.5% of patients. Treatment-related adverse events leading to dose interruptions or discontinuations were more common before the protocol amendment. It is noteworthy that 3 patients died after treatment discontinuation, with one deemed treatment-related, as previously mentioned. Dr. Rana McKay: Thank you, Neeraj, for a great summary. The pathological complete responses observed show promising activity for sacituzumab govitecan as a neo-adjuvant therapy and a window for bladder-sparing approaches, which is definitely exciting news for our patients! However, although the 3 deaths encountered in a neo-adjuvant setting could be concerning, the improvement of the safety profile after protocol amendments is reassuring and supports the continuation of the study. Dr. Neeraj Agarwal: Before wrapping up the bladder cancer section, would you like to share your insights with our listeners on Abstract 4518, titled “Quantitative circulating tumor DNA (ctDNA) assessment in patients with advanced urothelial carcinoma treated with pembrolizumab or platinum-based chemotherapy from the phase 3 KEYNOTE-361 trial”?  Dr. Rana McKay: Sure. So, the KEYNOTE-361 trial was a randomized phase 3 study with 3 arms that included pembrolizumab plus chemotherapy, pembrolizumab monotherapy, or chemotherapy alone in patients with previously untreated advanced urothelial carcinoma. The results showed that neither the combination of pembrolizumab plus chemotherapy nor pembrolizumab monotherapy improved survival outcomes compared to the chemotherapy arm. So, in this exploratory analysis presented at ASCO24, Dr. Tom Powles and colleagues sought to assess the role of ctDNA as a potential biomarker between the pembrolizumab monotherapy arm and the chemotherapy arm. Tumor tissue mutations were evaluated using whole exome sequencing, and plasma ctDNA was assessed with the Guardant 360 assay. Changes in ctDNA from pre-treatment cycle 1 to on-treatment cycle 2, so 3 weeks post-baseline assessment, were quantified by the maximum variant allele frequency of tumor tissue-specific mutations.  Results showed that lower baseline ctDNA levels were associated with improved clinical outcomes of response in the pembrolizumab arm but not in the chemotherapy arm. This improvement in the pembrolizumab arm was also robust to adjustment for tumor mutational burden and PD-L1. Additionally, chemotherapy led to a ctDNA clearance rate of 41% compared to 11% in the pembrolizumab arm. Patients who had a large ctDNA reduction with pembrolizumab had significantly improved outcomes compared to those achieving a large reduction with chemotherapy with a hazard ratio of 0.25. However, this did not replicate in patients who did not achieve a large reduction, as these patients had similar outcomes across both arms. Let's switch gears to kidney cancer and start with Abstract 4508, reporting the final OS analysis from the JAVELIN Renal-101 trial. Neeraj, what would you like to tell us about this abstract? Dr. Neeraj Agarwal:  Well, as a quick reminder, the JAVELIN Renal-101 was a randomized phase 3 trial where patients with previously untreated advanced or metastatic clear cell renal cell carcinoma were randomized to receive either the combination of avelumab plus axitinib or sunitinib. In previous analyses, the combination of avelumab and axitinib significantly improved PFS compared to sunitinib and was subsequently approved by the FDA for the first-line treatment of patients with advanced RCC in 2019. This superiority in PFS was maintained across the different analyses; however, OS data remained immature. In the abstract presented at ASCO24 by Dr. Robert Motzer from Memorial Sloan Kettering Cancer Center and colleagues, the authors reported OS results at a median follow-up of around 73 months and a minimum of 68 months for all patients, which is the longest follow-up for any ICI-TKI combination in RCC. The final analysis in the overall population favored the combination of avelumab plus axitinib with a median OS of 44.8 months compared to 38.9 months with sunitinib, however, this did not reach statistical significance with a hazard ratio of 0.88. The PFS results and safety profile were consistent with previous analyses.  Dr. Rana McKay: Thank you, Neeraj, for such a nice overview of this abstract. These new data could make this regimen less optimal than other ICI-TKI combinations in the first-line mRCC setting.   Dr. Neeraj Agarwal: I concur, Rana. Moving on to perhaps one of the most exciting GU abstracts featured, Abstract 4506, titled “Circulating kidney injury molecule-1 biomarker analysis in IMmotion010: A randomized phase 3 study of adjuvant atezolizumab vs placebo in patients with renal cell carcinoma at increased risk of recurrence after resection.” Rana, what are your thoughts on this abstract? Dr. Rana McKay: Well, first, I would like to take a step back and remind our audience that in the IMmotion010 trial, patients with resected intermediate to high-risk RCC with clear cell and/or sarcomatoid component were randomized in a 1:1 ratio to receive either atezolizumab or placebo. Investigator-assessed disease-free survival, which was the primary endpoint, favored the atezolizumab arm but did not reach statistical significance. In the abstract featured at ASCO24, Dr. Laurence Albiges and colleagues build on data previously reported in the ASSURE and CheckMate 914 trials and report provocative findings regarding a molecule known as kidney injury molecule 1 or KIM-1, which is a type 1 membrane glycoprotein that has been identified as a minimally invasive potential peripheral blood circulating biomarker. The KIM-1 level of 86 pg/ml was identified as the optimized threshold for defining post-nephrectomy KIM-1 high vs KIM-1 low subgroups in the IMmotion010 trial. KIM-1 levels were measured at baseline or pre-treatment, at cycle 4 day 1, and at disease recurrence or discontinuation without disease recurrence. Baseline characteristics were balanced between the KIM-1 high and KIM-1 low groups, except perhaps for a slightly higher pathological stage in the KIM-1 high subgroup.  I would like to highlight 3 key takeaways from this abstract. First, KIM-1 high level was associated with significantly worse DFS with a hazard ratio of 1.75. Second, patients in the KIM-1 high subgroup receiving atezolizumab had a 28% reduction in the risk of recurrence or death compared to those receiving placebo, while those in the KIM-1 low subgroup had comparable outcomes across both treatment arms. Third, patients in the KIM-1 high subgroup receiving atezolizumab were significantly less likely to experience an on-treatment increase in KIM-1 levels, which was associated with worse DFS in both high and low KIM-1 subgroups, regardless of treatment arm. Thus, these findings support the use of KIM-1 as both a predictive and prognostic biomarker in patients with RCC. Dr. Neeraj Agarwal: Yes, Rana, this is amazing data! I would like to add that these results warrant larger and, ideally, prospective studies to validate the utility of KIM-1 as a noninvasive biomarker for identifying minimal residual disease after nephrectomy and for predicting outcomes to immune checkpoint inhibitors. Dr. Rana McKay: Also, in the field of biomarkers, 2 abstracts interrogating different biomarkers in a different setting, so in patients with advanced or metastatic RCC were presented. Neeraj, could you tell us more about these abstracts? Dr. Neeraj Agarwal: Of course! I think you are referring to Abstracts 4504 and 4505. In abstract 4504, Dr. Toni Choueiri and colleagues sought to assess the clinical implications of different biomarkers in the CLEAR trial, which was a randomized phase 3 trial that led to the approval of the combination of pembrolizumab plus lenvatinib in the first-line mRCC setting. On the other hand, in abstract 4505, Dr. Brian Rini presented biomarker results in KEYNOTE-426, which was also a randomized phase 3 trial based on which the combination of pembrolizumab plus axitinib was approved in patients with mRCC. The authors in both trials sought to investigate the role of biomarkers in predicting treatment outcomes from 3 different angles. Starting with PD-L1 expression, the superiority of the combination arms over sunitinib was not impacted by PD-L1 status in both trials. Moving on to RCC driver gene mutations on whole exome sequencing, such as VHL, SETD2, PBRM1, and BAP1, ICI combination therapies improved outcomes regardless of mutation gene status, and this improvement was statistically significant with PBRM1 mutations in KEYNOTE-426 compared to wild-type PBRM1, but this did not replicate in the CLEAR trial. Finally, using transcriptomic signatures derived from RCC trials, especially the IMmotion 151 and JAVELIN Renal 101 trials, where 7 clusters or molecular subtypes were identified, the combination arms outperformed sunitinib in all clusters in both trials and the magnitude of this benefit differed across clusters.  Dr. Rana McKay: Thank you for this very interesting summary and comparison of the results of these 2 abstracts. These findings support the use of ICI-based combinations in all patients with mRCC as a first-line option. Although these abstracts could not identify specific biomarkers that could guide us clinicians in treatment selection, they provide very interesting biological insights on these molecular biomarkers that are, however, not yet clinically actionable. Dr. Neeraj Agarwal: Very interesting point, Rana. Moving on to prostate cancer, let's start with abstract LBA5000 titled, “Cabazitaxel with abiraterone versus abiraterone alone randomized trial for extensive disease following docetaxel: The CHAARTED2 trial of the ECOG-ACRIN Cancer Research Group (EA8153).” Rana, what is your takeaway on this abstract? Dr. Rana McKay: As a reminder to our audience, the CHAARTED2 trial was a randomized open-label phase 2 study that compared the combination of cabazitaxel and abiraterone to abiraterone alone in patients with mCRPC previously treated with ADT plus docetaxel in the hormone-sensitive setting. The primary endpoint was progression-free survival. After a median follow-up of 47.3 months, Dr. Christos Kyriakopoulos and colleagues reported in LBA5000 that patients receiving the combination of cabazitaxel plus abiraterone had a 27% reduction in the risk of progression or death. However, there was no significant difference in overall survival between the two arms, with a median OS of 25 months in the cabazitaxel+abiraterone arm and 26.9 months in the abiraterone arm, although the study was underpowered for this endpoint. Regarding the toxicity profile, the combination of cabazitaxel and abiraterone was overall well tolerated with more cytopenias, as expected.  Dr. Neeraj Agarwal: Very nice summary of this abstract, Rana. I would like to add that the treatment landscape of patients with mHSPC has evolved since the design of the study and now includes combination therapies of ADT + ARPI with or without docetaxel, and ADT + docetaxel is no longer a standard of care, which limits the applicability of these results in clinical practice today.  Dr. Rana McKay: Excellent point, Neeraj. Let's discuss Abstract 5001, titled “CYCLONE 2: A phase 3 study of abemaciclib with abiraterone in patients with metastatic castration-resistant prostate cancer”. Dr. Neeraj Agarwal: Sure! In the abstract featured at ASCO24, Dr. Matthew Smith and colleagues report the primary results of the CYCLONE 2 trial, which was a randomized phase 2/3 study that investigated the combination of abemaciclib plus abiraterone versus abiraterone monotherapy in patients with mCRPC. Stratification factors included radiographic progression at study entry, presence of measurable disease, and prior docetaxel for mHSPC. Part 1 of the study established the recommended phase 2 dose of abemaciclib at 200 mg twice daily. In part 2, patients were randomized to placebo or abemaciclib, and an adaptive interim analysis using prespecified criteria was performed and recommended the expansion of the study to part 3. The primary endpoint was investigator-assessed radiographic progression-free survival by RECIST 1.1 and PCWG3 criteria in the intention-to-treat population. At the time of the primary analysis, adding abemaciclib to abiraterone did not improve rPFS, with a hazard ratio of 0.83. The median rPFS was 22 months for the combination arm and 20.3 months for the abiraterone arm. The combination was well tolerated, and the safety profile was consistent with the known adverse events. Dr. Rana McKay: So, the addition of abemaciclib to abiraterone did not improve outcomes in patients with mCRPC. These findings suggest that no further investigation is warranted for abemaciclib or CDK4/6 inhibitors in biomarker-unselected patients with prostate cancer.  Dr. Neeraj Agarwal: Rana, what's your take-home message on Abstract 5006, titled “Health-related quality of life results from PRESTO (AFT-19), a phase 3 randomized trial of intensification of androgen blockade in patients with high-risk biochemically relapsed castration sensitive prostate cancer”? Dr. Rana McKay: So, as a reminder to our audience, the PRESTO trial was a randomized phase 3 study that assessed the effects of intensified androgen receptor blockade in patients with biochemically recurrent prostate cancer following local therapies. Patients with a PSA doubling time of less than 9 months and no evidence of metastatic disease were randomized to receive either 52 weeks of ADT alone, ADT plus apalutamide, or ADT plus apalutamide plus abiraterone. In their paper published earlier this year in the Journal of Clinical Oncology, the authors showed that patients receiving ADT plus apalutamide with or without abiraterone had significantly longer PSA-progression-free survival than those receiving ADT alone. In the oral presentation featured at ASCO24, Dr. Ronald Chen and colleagues report health-related quality of life outcomes that were assessed using various questionnaires or scales at baseline, at cycle 7, which is around 6 months on treatment, and at the end of treatment. Results showed that this intensified approach with apalutamide did not significantly increase severe adverse events, did not lengthen the time to testosterone recovery, and did not meaningfully increase common treatment-related symptoms such as hormonal symptoms, sexual dysfunction, hot flash interference, and fatigue. Importantly, additional intensification with abiraterone did not further improve PSA-PFS but did increase the rate of serious adverse events, lengthened the time to testosterone recovery, and increased hot flash interference.  Dr. Neeraj Agarwal: So, in conclusion, the PRESTO trial supports using intensified androgen blockade with apalutamide to improve PSA-PFS in patients with high-risk biochemically recurrent prostate cancer without compromising health-related quality of life. However, adding abiraterone did not offer additional benefits and increased side effects.  Dr. Rana McKay: Let's move on to LBA5002 titled, “A randomized, double-blind, placebo-controlled trial of metformin in reducing progression among men on expectant management for low-risk prostate cancer: The MAST (Metformin Active Surveillance Trial) study.” Would you like to share your insights on this abstract with our listeners? Dr. Neeraj Agarwal: Absolutely. MAST was a randomized, double-blinded, placebo-controlled trial that investigated the impact of metformin on the progression of low-risk localized prostate cancer in patients choosing to undergo active surveillance. Eligible patients had biopsy-proven, low-risk, localized prostate cancer diagnosed within the past 6 months, characterized by a Gleason score of less than 6 observed in less than one-third of the total cores, less than 50% positivity in any one core, a PSA level of less than 10 ng/ml, and a clinical-stage between T1c and T2a. Patients were randomized in a 1:1 ratio to receive either metformin 850 mg twice daily or placebo for three years. All patients underwent repeat prostate biopsy at 18 and 36 months. The primary endpoint was time to progression, defined as the earliest occurrence of primary prostate cancer therapy, such as prostatectomy, radiation, hormonal therapy, or pathological progression on subsequent biopsies, which was defined as more than 1/3 of total cores involved, at least 50% of any one core involved, or Gleason pattern 4 or higher. The study included 407 patients, with 204 receiving metformin and 203 receiving a placebo. Results presented by Dr. Anthony Joshua showed no statistically significant difference in progression-free survival, including therapeutic and pathologic progression, with an unadjusted hazard ratio of 1.08.  Interestingly, there was a signal that patients with a BMI more than 30 had a detriment to taking metformin with a higher risk of progression compared to those receiving placebo with an unadjusted HR of 2.39 and a p-value of 0.01. Dr. Rana McKay: I would like to add that this study showed that metformin use does not prevent the progression of low-risk localized prostate cancer on active surveillance and could represent a potential detriment for patients with high BMI at study entry. Dr. Neeraj Agarwal: Yes, Rana, I concur. Any final remarks before we conclude today's podcast? Dr. Rana McKay:  Thank you, Neeraj; it's been wonderful being here with you today and you having me on the podcast to highlight these important advances and the amazing work that many investigators are conducting and the patients who were involved in the context of these trials. It's really excellent to see these updated results.   Dr. Neeraj Agarwal: Before we wrap up this podcast, I would like to say that we have reviewed a selection of abstracts addressing prostate, bladder, and kidney cancer, which are significantly impacting our medical practices now and in the near future. Rana, thank you for sharing your insights today. These updates are undoubtedly exciting for the entire GU oncology community, and we greatly appreciate your valuable contribution to the discussion. Many thanks. And thank you to our listeners for joining us today. You will find links to the abstracts discussed today on the transcript of this episode. Finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review, and subscribe wherever you get your podcasts.   Find out more about today's speakers:    Dr. Neeraj Agarwal   @neerajaiims   Dr. Rana McKay  @DrRanaMcKay     Follow ASCO on social media:      @ASCO on Twitter      ASCO on Facebook      ASCO on LinkedIn         Disclosures:        Dr. Neeraj Agarwal:         Consulting or Advisory Role: Pfizer, Bristol-Myers Squibb, AstraZeneca, Nektar, Lilly, Bayer, Pharmacyclics, Foundation Medicine, Astellas Pharma, Lilly, Exelixis, AstraZeneca, Pfizer, Merck, Novartis, Eisai, Seattle Genetics, EMD Serono, Janssen Oncology, AVEO, Calithera Biosciences, MEI Pharma, Genentech, Astellas Pharma, Foundation Medicine, and Gilead Sciences     Research Funding (Institution): Bayer, Bristol-Myers Squibb, Takeda, Pfizer, Exelixis, Amgen, AstraZeneca, Calithera Biosciences, Celldex, Eisai, Genentech, Immunomedics, Janssen, Merck, Lilly, Nektar, ORIC Pharmaceuticals, Crispr Therapeutics, Arvinas      Dr. Rana McKay:   Consulting or Advisory Role: Janssen, Novartis, Tempus, Exelxis, Pfizer, Bristol-Myers Squibb, Astellas Medivation, Dendreon, Bayer, Sanofi, Merck, Vividion, Calithera, AstraZeneca, Myovant, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Pfizer, Bayer, Tempus

Interview with Albert S. Chiou, MD, MBA, author of Single-Lesion Skin Cancer Risk Stratification Triage Pathway. Hosted by Adewole Adamson, MD, MPP. Related Content: Single-Lesion Skin Cancer Risk Stratification Triage Pathway

Interview with Albert S. Chiou, MD, MBA, author of Single-Lesion Skin Cancer Risk Stratification Triage Pathway. Hosted by Adewole Adamson, MD, MPP. Related Content: Single-Lesion Skin Cancer Risk Stratification Triage Pathway