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    Latest podcast episodes about Spotlight

    Neurology Minute
    March 2026 President Spotlight: Preview of the Annual Meeting

    Neurology Minute

    Play Episode Listen Later Mar 9, 2026 3:21


    In the March episode of the President's Spotlight, Dr. Jason Crowell and Dr. Natalia Rost share key updates and strategic insights for the upcoming April meeting in Chicago.  Stay informed by watching the President's Spotlight video.   Show transcript:  Dr. Jason Crowell: Hey, this is Jason Crowell. Thanks for listening to today's Neurology Minute. Once again, this month, we have Natalia Rost joining us, the president of the AAN for her presidential spotlight. Natalia, the sun is starting to come out. The flowers are starting to bloom. Spring is here. What is going on with the academy? What would you like to tell us about this month? Dr. Natalia Rost: These are exciting times indeed. Our annual meeting is just one month away. And so I'm looking forward to all of us coming together to learn, share ideas, and to connect. And this year, the world's largest neurology event is even larger. And I like to say it's my meeting of 15,000 friends. Dr. Jason Crowell: Terrific. For those who are listening today who haven't heard about the annual meeting, what would you like for them to know about it? Dr. Natalia Rost: Well, so the meeting takes place April 18th through 22nd in Chicago and online. And like so many, I love Chicago. It's a world-class city. It's a major travel hub and making it easy for many of us to attend. And we're expecting presentations of more than 3,500 abstracts. It's a new record for our meeting. Registration is also trending ahead of previous years, so now is the time to make your plans. Dr. Jason Crowell: And what would you say are the three things that you look forward to the most every year at the meeting? Dr. Natalia Rost: Well, first of all, the Sunday of this meeting, April 19th, is our research day, which will focus on advancing neuroscience and the AAN's renewed commitment to research funding we talked about last month. It includes my presidential plenary, which is titled Neuroscience at the Crossroads, and which will feature interactive panels of seasoned neuroscience leaders and clinician scientists who are right in the midst of their exciting careers. We will have our research hub to take part in many opportunities to support our high quality research program, so that's going to be great. Another highlight is a celebration of the extraordinary accomplishments of Dr. Walter Koroshetz, the immediate past NINDS director, and a phenomenal neurologist who is our 2026 President's Award winner and who will join us at the Presidential Plenary. This is going to be a very special and spirited event. And also, I'm excited to debut the new Brain Hub this year. I hope folks will stop by. Along with that, we have a special museum exhibit and reception for the Neurology Journal's 75th anniversary. I sure will be stopping by both. Dr. Jason Crowell: I would say that people in the world of medicine often misunderestimate just how much fun neurologists can be. What fun is planned for the annual meeting this year? Dr. Natalia Rost: Oh yeah, we're on it. As always, we will have our celebrated annual meeting party on Sunday night. This year, the entire Griffin Museum of Science and Industry will be hours to explore while you enjoy your food, drinks, and conversation with colleagues. Dr. Jason Crowell: And for our listeners, where can they learn more about the annual meeting and all the details? Dr. Natalia Rost: Please register now at aan.com/am. This is an annual meeting you won't want to miss, so join me with everything neurology premier event has to offer. Dr. Jason Crowell: Terrific. Natalia, thanks so much. Looking forward to Chicago.  

    Spotlight English
    Art Therapy

    Spotlight English

    Play Episode Listen Later Mar 9, 2026 12:21 Transcription Available


    Megan Nollet and Patrick Woodward share about how music and art can be used to help people with disabilities, not only physical, but also mentally and emotional.https://spotlightenglish.com/uncategorized/art-therapy/Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

    Land & Livestock Report
    Senate Democrats' Bill Targets Packers

    Land & Livestock Report

    Play Episode Listen Later Mar 9, 2026


    Senate Democrats' Bill Targets Packers

    Panels to Pixels
    Panels to Pixels Podcast Episode #327 Wonder Man Season 1 Episodes 7 and 8 Spoiler Review!

    Panels to Pixels

    Play Episode Listen Later Mar 8, 2026 57:26


    Hey Panelers, Steve and Mark are here yet again, and we arewrapping up our coverage of Wonder Man Season 1 found on Disney Plus. Steve and Mark had a great time talking about how the showfinalized. They talked about what a Spotlight show is and a series on MarvelDisney Plus. The discussion also follows up with what we always ask after these shows conclude, about the character that was spotlighted for the one-off show. Check us out on Apple Podcast, Amazon Music, Deezer, Tune In, and Spotify,or whatever podcast player of choice you use. We Can be found on YouTube: Just Search Panels to Pixels Podcast!Subscribe! And just Check the Thumbs up if you like it! We would appreciate it! You can send Feedback at: Facebook.com/PanelsToPixels Email us: Panelstopixels1@gmail.com Instagram: @PanelsToPixelsPodcast For all Links just go to: https://piratecorpsentertainment.com/

    Beaveman and The Doc
    Put the taint in the tank to safeguard it from aliens

    Beaveman and The Doc

    Play Episode Listen Later Mar 7, 2026 78:32


    Send a textThis week the squad gets right into it with a case out of Tecumseh Michigan. Swan summarizes the case of accused plaintiff, innocent until proven guilty, Dale Warner charged with the murder of his wife. News flash, he's this weeks POS. Think he did it? Beaveman is pretty convinced. Then Drippy Steve brings the heat with an interesting mystery of the missing House Majority leader Thomas Hale Boggs in October of 1972. Aliens, plane crash, or did these folks pop smoke and get out of dodge to protect their anonymity for some other reason? The mystery continues. The Beaveman doesn't disappoint. After being told last episode that he needed to ramp it up a bit, he presents the devastating medical condition known as Fournier Gangrene. Can Steven handle the description and images, or does he become a pasty, pale, panty-waste? What do you think? Finally, Swan disappoints us all with some of the jokes that were very common when Beaveman was a young lad. Get ready for some of the worst, tasteless jokes of modern times. It's what we do. We are The Slaptail Squad, join our nation. Upcoming Shows for the BeavemanSpotlight on Insanity “Spotlight on Insanity” is the best mix of Stand-up Comedy and Improv. Hosted by Half Hazard, they will also perform improv between comics based on some of that comedian's material.Ticket link: https://grcmc.vbotickets.com/event/Spotlight_on_Insanity_Comedy_Show/182843Support the show

    Pick Up and Deliver
    Sept '25 – Feb '26 Movie Roundup

    Pick Up and Deliver

    Play Episode Listen Later Mar 7, 2026 12:59


    Brendan talks about the movies he watched in the last six months that weren't horror movies or Christmas movies. Join us, won't you?Mickey 17 (2025)Mickey 7 discussionParanoiaThe Woman in Cabin 10 (2025)Rear Window (2022)John Candy: I Like Me (2025)Margin Call (2011)Ponzi Scheme (2015)Spotlight (2015)Watergate (2019)The Life of Chuck (2024)Holding On: The Troubled Life of Billy Kerr (2018)Labyrinth (1986)Jim Henson's Labyrinth: The Board Game (2016)Notting Hill (1999), Sleepless in Seattle (1993)Fog of Love (2017)Rental Family (2025)Jiangshi: Blood in the Banquet Hall (2020)The Hobby: Tales from the Tabletop (2024)An Honest Liar (2014)What films did you watch in the last six months? Share your views over on boardgamegeek in guild #3269.

    Spotlight on the Community
    Creating Access to Quality Music Education: Fiona Chatwin on Building a ‘Home for Music'

    Spotlight on the Community

    Play Episode Listen Later Mar 7, 2026 27:55


    Fiona Chapman, Artistic and Executive Director of Villa Musica, discussed the organization's mission to provide quality music education to people of all ages and backgrounds. Villa Musica serves individuals from age two to over ninety, with 58 teaching artists on staff. The organization offers group classes for popular instruments like piano, violin, and guitar, and has expanded to a new facility in East County. Chapman also highlighted the Musical Biographies program, designed to help people with dementia and their caregivers through personalized music experiences. Villa Musica is planning a soft opening in May and a grand opening in August.About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    Healthy, Affordable, Local: The Suncoast Market Co-op Model for Community Impact

    Spotlight on the Community

    Play Episode Listen Later Mar 7, 2026 25:38


    Shannon Ratliff, Board Vice President of Suncoast Market Co-Op, discussed the 10-year journey to open the co-op in Imperial Beach, California. The project required extensive fundraising, totaling over $4 million, and community engagement. Suncoast Market sources 90% organic produce locally and offers a hybrid grocery model to cater to diverse community needs. The co-op aims to support local farms and producers, provide affordable nutrition, and foster community health. Shannon emphasized the importance of ongoing fundraising, community support, and shareholder investment to sustain the co-op. The store is open daily from 7 AM to 9 PM and offers a unique shopping experience with local products.About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    You Come In A Customer, You Leave As Family: Carlos Stance and Jordan Stance Discuss The Bowlegged BBQ Story

    Spotlight on the Community

    Play Episode Listen Later Mar 7, 2026 33:12


    Co-founder Carlos Stance and his son Jordan, the pit master of Bowlegged BBQ, a family-owned business in San Diego, discuss their mission to create a welcoming community environment. They emphasize the importance of quality, using traditional East Texas barbecue methods with a unique family blend of seasonings. Despite challenges like rising costs, they maintain high standards, ensuring every dish meets their quality criteria. The family is continuing their successful entrepreneurial journey as they are launching a high-quality boot company.  They also share some great advice for the other family businesses and the importance of faith in their model for success.  About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    I Write Therefore I Am: Richard Lederer Discusses His Love for Words, Writing, and Poker

    Spotlight on the Community

    Play Episode Listen Later Mar 7, 2026 27:21


    Richard Lederer, a prolific writer and UT columnist discusses his approach to writing, emphasizing the importance of maintaining humanity in technology and AI. He mentions his 65 books and his upcoming 66th, tentatively titled "I Write Therefore I Am." Richard also shares his involvement in local theater and his role as a senior instructor at Oasis. He advises aspiring journalists to pursue their passions with dedication. The conversation highlights Richard's love for puns and his family's success in poker, including his children Annie Duke and Howard Lederer.About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    Remembering Bill Walton: Friends and Teammates Reflect On A Champion for San Diego and His Servant Leadership

    Spotlight on the Community

    Play Episode Listen Later Mar 7, 2026 61:24


    "Remembering Bill Walton" is the theme of this episode, dedicated to remembering Bill Walton, a basketball legend from San Diego. Guests include Tom Davis, Mike Dupree, and Jim Bristol, who shared their personal experiences and memories of Walton. They discussed Walton's high school years, his leadership qualities, and his impact on the community. Walton's brother, Bruce, was also highlighted for his athletic prowess. The conversation also touched on Walton's post-basketball career in sportscasting and his philanthropic efforts. The episode emphasized Walton's intelligence, social activism, and his lasting legacy in San Diego.About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Rattlebox Games- Network Feed
    Sept '25 – Feb '26 Movie Roundup

    Rattlebox Games- Network Feed

    Play Episode Listen Later Mar 7, 2026 12:59


    Brendan talks about the movies he watched in the last six months that weren't horror movies or Christmas movies. Join us, won't you?Mickey 17 (2025)Mickey 7 discussionParanoiaThe Woman in Cabin 10 (2025)Rear Window (2022)John Candy: I Like Me (2025)Margin Call (2011)Ponzi Scheme (2015)Spotlight (2015)Watergate (2019)The Life of Chuck (2024)Holding On: The Troubled Life of Billy Kerr (2018)Labyrinth (1986)Jim Henson's Labyrinth: The Board Game (2016)Notting Hill (1999), Sleepless in Seattle (1993)Fog of Love (2017)Rental Family (2025)Jiangshi: Blood in the Banquet Hall (2020)The Hobby: Tales from the Tabletop (2024)An Honest Liar (2014)What films did you watch in the last six months? Share your views over on boardgamegeek in guild #3269.

    A.C.M.G. presents TALK TIME LIVE
    SELECT/START: SCOTT PILGRIM EX REVIEW

    A.C.M.G. presents TALK TIME LIVE

    Play Episode Listen Later Mar 6, 2026 126:23


    THIS WEEK: Plenty of announcements from Nintendo's Indy World showcase and Capcom's Spotlight showcase that we will discuss. PlayStation makes a strategic move from the land of PC. We also look at the career of former XBOX icon Phil Spencer. In our FINAL STAGE segment, I review SCOTT PILGRIM EX by Tribute Games. 

    Marketing Guides for Small Businesses
    Special Guest Molly Mahoney: The Spotlight Effect—Use AI to Build a Brand So Strong It Sells for You

    Marketing Guides for Small Businesses

    Play Episode Listen Later Mar 6, 2026 60:20


    What if your brand stood out so clearly that prospects instantly knew you were the only solution—and showed up ready to buy? In this energizing episode, digital marketing strategist, keynote speaker, and former NYC performer Molly Mahoney reveals how to harness “The Spotlight Effect” to build a human-first brand that scales with AI—without sounding like everyone else.

    Sustain
    Episode 285: Miranda Heath on Altruism & Burnout in Open Source

    Sustain

    Play Episode Listen Later Mar 6, 2026 44:11


    Guest Miranda Heath Panelist Richard Littauer Show Notes In this episode of Sustain, host Richard Littauer is joined by PhD student Miranda Heath to discuss her research on altruism and maintainer burnout in open source, and specifically her report on burn out in open source maintainers. Miranda shares insights from her study on what motivates people to act altruistically and how these behaviors manifest in open source communities. She delves into the common issues maintainers face, such as changing motivations and the systemic challenges that contribute to burnout. Drawing on examples from her research, including kidney donors and open source maintainers, Miranda explores how community support, mentorship, and better funding can help mitigate burnout. The conversation also touches on the unique challenges neurodiverse maintainers face and the importance of creating supportive environments for them. Press download now to hear more! [00:00:44] Richard introduces Miranda Heath, whom he met at FOSDEM, and she's built a major report on maintainer burnout. [00:02:04] Miranda studies what motivates people to benefit others, how “altruism” is often framed too narrowly, and she points out neglected forms. [00:03:40] Richard asks about a name for the type of altruism, and they land on “collective altruism” as a useful label for shared/commons based giving. [00:04:25] Miranda explains her work on anonymous kidney donors and the key insight from the kidney donors is that altruism can be mundane. [00:06:45] Looking at the motivations of open source developers, Miranda sees overlap between altruistic impulses and open source and contrasts this with academia's paywall-driven publication system. [00:08:36] They discuss how motivation changes which leads to burnout risk, and Richard brings up Miranda's maintainer burnout report and what it was based on. [00:10:13] Miranda describes how this report started and what she wanted to change. [00:13:21] What are some systematic solutions for burnout? Miranda argues “money vs people” is a false dichotomy: respecting maintainers includes making it possible to live. Burnout is worsened by “double shift” dynamics and “Labor of love is still labor.” [00:16:18] Richard notes many maintainers are paid through employers, Miranda talks about paid maintainer roles still carry burnout risk, and some research done by Robert Karasek in the late 70's. [00:20:14] Miranda draws from social psychology: communities run on group norms (often unspoken), and emphasizes we need to make beneficiaries feel part of the in-group, so they adopt norms. [00:22:36] Richard highlights the Open Source Pledge and policy approaches like the Cyber Resilience Act, and Miranda notes policy could reduce autonomy and increase burnout if rigid. [00:26:22] What happens after burnout? Miranda believes we should prevent unwanted exits, normalize “sunsetting” conversations, and have a plan to wind down a project. [00:31:17] There's a discussion on how burnout shouldn't equal personal failure, and an example is brought up with the Tailwind CSS tensions. [00:35:19] Miranda stresses the importance of mentorship for community roles to be filled, Richard cites Abby Cabunoc's “3 C's” for mentor-worthy contributors, and Miranda mentions the concept of “Mentorship Triangle.” [00:38:03] Find out where you can follow Miranda and her work online. [00:38:27] We wrap with Miranda sharing there's an important gap with neurodivergence and autistic burnout and how more research needs to be done. Quotes [00:15:13] “Maintenance work is work, but a labor of love is labor.” Spotlight [00:40:47] Richard's spotlight is the klezmer band, OCH VEY. [00:41:33] Miranda's spotlight is the puzzle game, TR-49. Links SustainOSS podcast@sustainoss.org richard@sustainoss.org SustainOSS Discourse SustainOSS Mastodon SustainOSS Bluesky SustainOSS LinkedIn Open Collective-SustainOSS (Contribute) Richard Littauer Socials Miranda Heath Website Sentry Open Source Pledge Job Demands, Job Decision Latitude, and Mental Strain: Implications for Job Redesign by Robert Karasek, Jr. (Sage Publications) Cyber Resilience Act Abby Cabunoc Mayes-The Synthetic Senior: Rethinking Free Software Mentorship in the AI Era (FOSDEM 2026 talk video) OCH VEY Instagram TR-49 Credits Produced by Richard Littauer Edited by Paul M. Bahr at Peachtree Sound Show notes by DeAnn Bahr Peachtree Sound Special Guest: Miranda Heath.

    News Talk 920 KVEC
    Hometown Radio 03/05/26 3:30p: Spotlight on the San Luis Obispo Symphony

    News Talk 920 KVEC

    Play Episode Listen Later Mar 6, 2026 44:04


    Hometown Radio 03/05/26 3:30p: Spotlight on the San Luis Obispo Symphony

    Mission Forward
    Leading Beyond Resilience with Tonia Wellons

    Mission Forward

    Play Episode Listen Later Mar 5, 2026 33:30


    In a recent staff survey at the Greater Washington Community Foundation, 100 percent of employees said they were clear on the organization's mission and vision.Six years ago, that number was 39 percent.That gap is what happens when an organization decides, at the height of a pandemic, to stop thinking in three-year cycles and commit to a ten-year framework instead. Tonia Wellons was thirty days into her role as president and CEO when COVID hit — canceling a 600-person gala, sending staff home, building a crisis response from scratch. And then, as the uncertainty stretched on, she and her board planned further out, not less. Because the plan isn't a prediction. It's a fixed point. And fixed points are most valuable when everything else is moving.What's moving right now is almost everything. In 2020, the crisis had a shape — federal resources flowing outward, community energy concentrating around visible needs. Now the disruption comes from a different direction. What Wellons calls "dispersed energy" has replaced collective momentum: people still care, but without a center of gravity, that care is very hard to organize — and very hard to sustain.Nonprofit leaders are resilient by training. But resilience and endurance are different capacities. Over ten consecutive years of crisis, the sector has been asked to sustain both, and the cumulative cost is real. Boards that aren't actively asking how to lighten that load are going to lose people — not in a single wave, but in quiet rolling exits. Some of those, Wellons is careful to note, are the right response. A thoughtful departure or sabbatical isn't failure. It's a sector populated by human beings.The same honesty shapes how she talks about the foundation-nonprofit relationship. The power dynamic is real, she says. But the way through it is relational, not structural — funders explaining why they stopped doing something, nonprofits naming the blind spots that foundations can't see from where they sit. The alignment the sector keeps reaching for will arrive person to person, or not at all.Last fiscal year, the Greater Washington Community Foundation granted approximately $70 million — a record — while donor giving and national philanthropic support both reached new highs. None of it happened because the environment got easier. It happened because the foundation had a fixed point, and a leader who understood that holding steady and standing still are not the same thing.Links & NotesRead the Insights on Purpose™ ReportThe Greater Washington Community Foundation (00:00) - Welcome to Mission Forward (01:22) - Introducing Tonia Wellons and the Greater Washington Community Foundation (08:12) - Making Room for Planning (13:52) - On Resilience (28:04) - A Spotlight on the Good

    China In Focus
    Pentagon: Iran War Will Not Affect Munitions for Taiwan - China in Focus

    China In Focus

    Play Episode Listen Later Mar 5, 2026 23:17


    00:00 Intro01:18 Pentagon: Iran War Will Not Affect Munitions for Taiwan02:54 Report: Defense Systems From China, Russia Fail in Iran05:17 Allies Back U.S. in Warning to China06:23 China Unlikely to Back Iran Beyond Own Interests07:48 China's Oil Dilemma After U.S.-Israeli Strikes on Iran10:50 Chinese FM: “Indiscriminate Use of Force” Unacceptable11:39 Spotlight on China's New Five-Year Plan12:07 What Are China's “Two Sessions”?12:23 China's 2026 Agenda and Five-Year Plan14:52 Protests Across China as Beijing Holds Major Event16:36 CCP's Annual Meeting to Unveil Tech Race Road Map19:04 Police Probe Assault on Faith Group Adherent in London21:55 London Police Arrest 3 on Suspicion of Spying for China

    #HashtagFinance
    Silver Swings, Capital Rotates, and Opportunity Emerges on The Market this Month | S2-E2

    #HashtagFinance

    Play Episode Listen Later Mar 5, 2026 23:12


    Spotlight on Migraine
    Migraine Prevention Explained: When to Start, Why It Matters & What Success Looks Like

    Spotlight on Migraine

    Play Episode Listen Later Mar 4, 2026 20:14


    You've probably heard about migraine prevention, but what does it actually mean? In Part 1 of this two-part Spotlight on Migraine series, host Molly O'Brien sits down with neurologist and headache specialist Dr. Jessica Ailani to break down the basics of migraine prevention. They discuss types of prevention, who should consider preventive treatment, why reducing migraine frequency matters, and how to set realistic goals focused on improving quality of life—not just lowering headache days. Read the transcript at https://www.migrainedisorders.org/pod... Dr. Ailani explains:  When migraine prevention is recommended (often around 5–6 migraine days per month) How to reshape our thoughts around prevention. It's not all about fewer headache days; it's about reducing disability, improving independence, and bettering quality of life. The full range of prevention options What to consider if you're hesitant to start due to side effects, cost, or insurance barriers This is the first part of the Association of Migraine Disorders' two-part series on migraine prevention. In Part 2, we'll dive into specific treatment options and how to tailor a prevention plan to work best for you. *The contents of this video are intended for general informational purposes only and do not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. AMD does not recommend or endorse any treatment, products, or procedures mentioned. Reliance on any information provided by this content is solely at your own risk.

    Spotlight on the Community
    Proximity, Trust, and Generational Wealth: Inside the Sister Cities Project Ecosystem

    Spotlight on the Community

    Play Episode Listen Later Mar 4, 2026 31:32


    Sean McClondon, Founder and CEO of the Sister Cities Project, and Leslie Bridges, Volunteer and Chief Impact Officer, discuss building an ecosystem that connects affluent and underserved neighborhoods to drive racial equity, economic mobility, and generational wealth in San Diego. They share stories of cross-community partnerships, workforce development and support for Black women entrepreneurs through collaborations with organizations such as the Jackie Robinson YMCA. About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    Media Literacy, Critical Thinkers and the Power to Gather: Storytelling as Social Impact

    Spotlight on the Community

    Play Episode Listen Later Mar 4, 2026 28:16


    Diana Cervera, Community Engagement and Programs Manager at Media Arts Center San Diego, talks about how the upcoming San Diego Latino Film Festival, the Digital Gym Cinema, and media literacy programs create a pipeline for underrepresented voices and future leaders. Cervera is bullish on how strategic support of the arts, youth education and inclusive storytelling elevates community impact.About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    Championing Business and Empowering Leaders = Building a Thriving Regional Economy

    Spotlight on the Community

    Play Episode Listen Later Mar 4, 2026 30:25


    Chris Cate, President & CEO of the San Diego Regional Chamber of Commerce, and Jimena Villaseñor-Martinez, the Chamber's Business Programs Manager, discuss championing businesses, empowering leaders, and driving a thriving regional economy. They explore small business resiliency, cross‑border collaboration, and how executives can plug into the region's entrepreneurial ecosystem and leadership pipeline. About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    Father Joe's Villages: A Legacy of "Lifting Them Up in Their Humanity"

    Spotlight on the Community

    Play Episode Listen Later Mar 4, 2026 27:02


    Deacon Jim Vargas, President and CEO of Father Joe's Villages (FJV), and Deacon John Roberts, Chaplaincy and Wellness Program Manager, discuss innovative homelessness solutions, mind‑body‑spirit wellness and the power of FJV's more than 6,000 volunteers. Vargas and Roberts explore how executives can align corporate philanthropy, workforce housing, and community partnerships to create measurable social impact. Roberts chats about FJV's "bike" program.About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    From Impactful Summer Program to Voices of Impact: The Young Entrepreneurs

    Spotlight on the Community

    Play Episode Listen Later Mar 4, 2026 23:55


    Shane Stamm'ler Adamson, Founder and Host of Voices of Impact, and Jim Yang, a Voices of Impact Co‑Host and Scriptwriter, discuss how student‑driven storytelling is bridging the gap between education and impact through powerful global youth stories. Adamson and Yang note how emerging leaders, social impact innovators, and future changemakers are using podcasts to elevate community voices and inspire real‑world action. About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight on the Community
    Retirement Made Simple: Paying Yourself First and Designing Lifestyle Security

    Spotlight on the Community

    Play Episode Listen Later Mar 4, 2026 28:46


    Richard Tassiello, President and Founder of Retirement Strategies Group, chats about "retirement made simple," behavioral mindset shifts, and Roth IRA strategies that can build true lifestyle security. Tassiello emphasizes how one should "pay yourself first" when it comes to saving for retirement and the importance of getting into a mindset of beginning to save for the future at a young age.  About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

    Spotlight English
    International Womens Day

    Spotlight English

    Play Episode Listen Later Mar 3, 2026 14:15 Transcription Available


    How will you celebrate women today? Tell us what you will do. And then listen to today's Spotlight program on International Women's Day. Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to hear programs in English: Website: http://spotlightenglish.com/

    Spotlight English
    A Lion Called Christian

    Spotlight English

    Play Episode Listen Later Mar 3, 2026 14:12 Transcription Available


    Would you want to own a lion as a pet? Today, we look at two men who bought a lion, and the surprising results of that decision.Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

    SeventySix Capital Leadership Series
    Maury Gostfrand, Executive Vice President of The Montag Group - SeventySix Capital Sports Leadership Show

    SeventySix Capital Leadership Series

    Play Episode Listen Later Mar 3, 2026 38:27


    On this episode of the SeventySix Capital Sports Leadership Show, Wayne Kimmel interviewed Maury Gostfrand, Executive Vice President of The Montag Group.Gostfrand joined The Montag Group in January, 2018 as Partner & Executive Vice President. Prior to joining The Montag Group, Maury was the President and Founder of Vision Sports Group, a New York-based sports management and marketing agency representing primarily sports broadcasters and coaches.Gostfrand graduated from the University of Michigan in 1991 and began his career with the New York-based firm, Athletes and Artists, serving as the Director of Marketing. While at A & A, he was responsible for securing marketing opportunities for the clients, which included broadcasters, professional athletes and Olympic athletes. Gostfrand then attended University of Miami School of Law, and while in law school, worked for Impact Sports in Boca Raton, Florida, representing professional athletes, including NFL and NBA players. In 1996, he joined New York-based RLR Associates, an agency which represents sports broadcasters, where he served as an agent for nine years.Gostfrand dedicates a lot of time to charitable causes including The Joe Torre Safe At Home Foundation, where he has served as a board member since it was launched in 2002, and MVP Charity, where he has served as a board member since 2017.Gostfrand and his family reside in Chappaqua, New York.Chapters00:00 Introduction to Maury Gosfran and the Montag Group02:16 Role of an Agent in Sports Media04:52 Client Relationships and Communication13:27 Impact of NIL and Evolving Media Landscape16:31 Transitioning Athletes to Broadcasting Careers21:54 The Importance of Social Media for Talent23:29 Spotlight on Rising Stars in Broadcasting26:19 Advice for Aspiring Broadcasters28:04 Surprises in the Sports Media Industry29:48 Supporting Clients in Podcasting31:04 Reflections on Mentorship and Career Growth

    GRAPPL Spotlight
    WWE Elimination Chamber Spotlight Review w. Benno & Matty (Danhausen debuts, Elimination Chamber Review, WrestleMania, Punk & Roman)

    GRAPPL Spotlight

    Play Episode Listen Later Mar 3, 2026 103:46


    Hey all,We were live today for the full Spotlight review of WWE Elimination Chamber, plus more talk on DANHAUSEN, Punk vs Roman, WrestleMania, some AEW news and notes, NJPW's New Beginning in the USA fallout and more.Enjoy!BennoGRAPPL Spotlight is produced with support from our Patrons and YouTube members, with special thanks to Patreon Kings and Queen Of The Mountain - Conor O'Loughlin, Eddie Sideburns, Chris Platt, Carl Gac, Sophia Hitchcock, Simon Mulvaney & Marty Ellis!You can find all of our live shows on YouTube by becoming a Member at ⁠http://www.Youtube.com/@GRAPPL,⁠ or join us on Patreon for both live video and audio replays at ⁠http://www.patreon.com/GRAPPL!⁠You can also join us on the GRAPPL Discord for free athttps://discord.gg/KqeVAcwctS⁠ Hosted on Acast. See acast.com/privacy for more information.

    Quilting on the Side
    Stickers, Shaking Hands, and Sewing Seeds: Authentic Networking for Quilting Industry Events

    Quilting on the Side

    Play Episode Listen Later Mar 3, 2026 32:09 Transcription Available


    Send a textTaking your quilt business from a digital screen to a physical trade show booth can feel like a high-stakes challenge. In this episode, Tori and Andi pull back the curtain on the "messy middle" of booth prep and the vulnerability of being seen. You'll discover:The "Top-Down" Strategy: How to design for visibility so your brand is seen from across the room.Pro-Tips on a Budget: Why wooden crates and magnetic LEDs are a business owner's best friend.The Introvert's Secret Weapon: How sticker trading turns awkward networking into a fun connection.The Personalized Pitch: Why a "gift packet" lands better partnerships than a generic brochure.Perfect for any creative entrepreneur ready to step into the spotlight. Join us as we bridge the gap between digital magic and real-life connection.Mentioned in the Episode: Blog Post: Your h+h Roadmap  Craft to Career Episode with Darrin Stern  Our episode with Brandy, The Quilter on Fire  Register for h+h  Chapters[00:05] - Welcome & The "Why" Behind Booth Prep[01:46] - Navigating H&H Americas: B2B vs. B2C and Booth Basics[02:45] - The "Spotlight" Strategy: Why You Shouldn't Display Everything[03:20] - From Digital to Physical: Turning Marketing Concepts into "Thought Bubbles"[05:43] - The Booth as a Landing Page: Designing for the Customer Journey[07:39] - Andi's Trade Show Past & Using "Top-Down" Visibility[10:09] - The Magic of Wooden Crates: Height, Storage, and Aesthetic[11:26] - Beyond the Business Card: Postcards, Brochures, and QR Codes[15:19] - The Trifold Truth: Focusing Your Message to Avoid Confusion[18:20] - The Personalized Pitch: Turning Partnerships into "Gifts"[23:18] - Sticker Culture: The Introvert's Secret Weapon for Networking[28:06] - Strategic Lighting: Magnetic LEDs and Gallery Vibes[30:06] - Outro & Final ReflectionsWant More Quilting Business Content?

    Triple-T for Knife Makers
    E107: Jerid is sleepy

    Triple-T for Knife Makers

    Play Episode Listen Later Mar 3, 2026 74:49


    We're both back to entertain! Hear all about Jerid's trip, his explosive electronics and everything else going on in our shops!Your hosts:Denis Tyrell of Tyrell Knifeworks:IG: @tyrellknifeworksYouTube: https://www.youtube.com/c/TyrellKnifeworksWebsite: https://www.tyrellknifeworks.comFacebook: https://www.facebook.com/people/Tyrell-Knifeworks/61558767232017/Jerid Sandoval of Echo Blades:IG: @echo_bladesFacebook: https://www.facebook.com/people/Echo-Blades/100085394408004/Maker's Spotlight: https://www.instagram.com/lucasperesknives/ https://www.instagram.com/ruggedmountainbladesOur sponsors:Two Basterds Tx Smithy & Supplies: @twobasterdshammersMaritime Knife Supply: http://maritimeknifesupply.comPelican Paste: https://pelicanpaste.com (Use TTT10 for 10% off!)Baker Forge and Tool: https://www.bakerforge.com (Use TTT10 for 10% off!)Grip Tech Composites: https://rocksolidscales.com/ (Use TTT10 for 10% off!)Evenheat Kilns: Https://Evenheatkilns.com/Ameribrade: https://www.ameribrade.com/The Drop Point: https://thedroppoint.com/Podcasts we think you'll like: Hustle and Grind Work For It Fire and Steel KnifeTalk FullBlast ForgeSideChat Artisans of Steel Knife Perspective

    Flexikon
    #116 Supplements: Selbstoptimierung für 3,99?

    Flexikon

    Play Episode Listen Later Mar 3, 2026 55:39


    Wir haben das mal kurz für euch durchgerechnet: Eine durchschnittlich sportliche Frau deckt ihren Proteinbedarf mit täglich 2,3 Kilo Rosenkohl. Alternativ wären auch 12 bis 13 Eier denkbar. Wenn ihr ein 90 Kilo-Kerl seid, der gerade auf Masse pumpt, könnt ihr da noch ein paar Schälchen körnigen Frischkäse drauflegen. Kurz: Ja, man kann alle Nährstoffe über die Nahrung abdecken, das ist hier auch ausdrücklich erwünscht, in der Praxis gelingt das aber nicht immer, und da kommen die Nahrungsergänzungsmittel ins Spiel. Von Ashwagandha bis Zink ist fast alles in der Drogerie der Wahl verfügbar. Aber was braucht man? Wer braucht was? Braucht man überhaupt irgendwas? Und welche Supplements sind so überflüssig, dass man sich genauso gut den Inhalt des Staubsaugerbetels durch die Nase ziehen könnte? Haben wir Professor Dr. Jürgen Gießing gefragt. Als Sportwissenschaftler mit dem Schwerpunkt Muskelaufbau hat es ihm besonders das Kreatin angetan. Dieses Strukturprotein soll Sportler: innen unter die Arme greifen. Und tatsächlich hält das Pulver, was es verspricht, sagt Jürgen Gießing. Zu dem Thema hat er ein ganzes Buch geschrieben, als Einstieg könnt ihr euch aber auch erstmal diese Folge anhören. Als „Nutri-Licous“ berät Michelle Lang Frauen in Gesundheitsfragen, und da spielen vor allen Dingen die Hormone eine Rolle. Hormone, Frauengesundheit – das sind Wörter, die versprühen den Charme von Potpourri-Schalen und Farbberatung – aber zusammen mit Michelle holen wir die Hormone raus aus der Schmuddelecke und rücken sie ins Spotlight, in das sie gehören. Denn während sich der männliche Hormonzyklus durch ein morgendliches Aufbäumen und anschließendes Abflachen auszeichnen, ist bei Frauen ein ganzen Hormonorchester damit beschäftigt den Zyklus, die Stimmung, das allgemeine Wohlbefinden zu regulieren und oft genug ins Chaos zu stürzen. Aber auch da kann man mit Supplements gegensteuern, sagt Michelle. Hier hat Anne die Zahlen her: Nahrungsergänzungsmittel: Verbraucherverhalten und Gesundheitsversprechen Und hier unser Podcast-Tipp zum Thema Abnehmspritze: https://www.ardaudiothek.de/episode/urn:ard:episode:36f992e7e9427f31/ flexikon@ndr.de

    The Locker Room with Billy Schweim
    Saturday Morning Feb 28th in The Locker Room with Billy Schweim

    The Locker Room with Billy Schweim

    Play Episode Listen Later Mar 2, 2026 116:32


    Producer Nick Earnshaw and my intern Erin Ewing join me in the studio. We get a Phillies Spring Training report from Paul Lundholm who is in Clearwater Fla. Flyers and Sixers discussion plus we'll get our "High School Athletes in the Spotlight" with Fran Mclaughlin.

    The Leader Assistant Podcast
    #365: Diana Brandl and Lauren Bradley on How Executive Assistants Can Thrive

    The Leader Assistant Podcast

    Play Episode Listen Later Mar 1, 2026 57:22 Transcription Available


    Diana Brandl is a longtime C-Suite assistant, and host of the Executive Office Insights podcast.In this spotlight episode, Diana speaks with Lauren Bradley about how EAs can thrive.Show Notes -> leaderassistant.com/365 --It's the last day of the offsite and it was exactly what the team needed. The CEO pulls you aside to say, “Thank you. This was next level.”Your secret? You used Offsite. They handled the venues, negotiations, and logistics – so you could focus on shaping the experience.Sound too good to be true? It's actually within reach. (And it can even save you money.)See how at leaderassistant.com/offsite. --Are you ready to level up? Enroll in The Leader Assistant Academy at leaderassistant.com/academy to embrace the Leader Assistant frameworks used by thousands of assistants.More from The Leader Assistant... Book, Audiobook, and Workbook -> leaderassistantbook.com The Leader Assistant Academy -> leaderassistantbook.com/academy Premium Membership -> leaderassistant.com/membership Events -> leaderassistantlive.com Free Community -> leaderassistant.com/community

    The New Statesman Podcast
    Rare diseases: from lived experience to lasting treatments | Sponsored

    The New Statesman Podcast

    Play Episode Listen Later Mar 1, 2026 21:16


    To mark Rare Disease Day, this special Spotlight episode explores why rare diseases - affecting an estimated one in 17 people in the UK – still face years of diagnostic delays and limited treatment options.Host Sarah Darwood speaks to CEO of LifeArc Dr Sam Barrell and Terry Pirovalakis, whose son Michael has been diagnosed with the rare neurological disorder SPG50. Their discussion looks at the reality of the “diagnostic odyssey”; gaps in data, investment and regulatory pathways; and the financial and structural challenges that limit progress in rare conditions.They also explore the growing role of parents as advocates and innovators, the case for a national rare disease champion, and why a more joined-up approach across government, regulators, industry and charities is essential to delivering faster diagnoses and access to life-changing therapies.This New Statesman podcast episode has been fully funded by LifeArc.Find out more about LifeArc's Taskforce Report and recommendations.LISTEN AD-FREE:

    Woman's Hour
    Weekend Woman's Hour: Tracey Emin, SEND reforms, Student midwives

    Woman's Hour

    Play Episode Listen Later Feb 28, 2026 57:42


    A 40-year career retrospective of Dame Tracey Emin's work has opened at the Tate Modern in London, featuring many of the artist's most iconic pieces, from her controversial, Turner Prize shortlisted My Bed (1998) to her neon artworks, textiles, bronze sculptures, photos, and paintings. Called A Second Life, it explores the connections and tensions between her early career and the work she's created since 2020, when she was diagnosed with cancer and underwent a huge operation. Tracey joins Anita Rani to discuss her body of work.Student midwives have contacted us to say many of them are struggling to find jobs despite a serious shortage of midwives in the NHS. A new survey from the Royal College of Midwives finds 31% of newly qualified midwives are still not employed in the role, and the majority of those who have found employment are on fixed-term contracts. Nuala McGovern hears from Safia, who is in her final year of midwifery training, and Gill Walton, Chief Executive of the Royal College of Midwives.Molly vs the Machines is a new feature-length documentary that tells the story of Ian Russell and his fight for online safety after his daughter Molly took her own life in 2017 following months of viewing content relating to self-harm and suicide on social media. Molly's friends Charlotte Campbell and Sophie Conlan tell Anita why it was important for them to take part in the film.In collaboration with our Send in the Spotlight podcast, Nuala speaks to Schools Standards Minister Georgia Gould about the government's proposed SEND reforms.Writer and actor Kyla Harris joins Clare McDonnell to discuss reframing disability with her acclaimed BBC comedy We Might Regret This, which she co-created.Presenter: Anita Rani Producer: Dianne McGregor

    Inspired Riding Podcast
    Advice from a Zen Master. A conversation with Peppermint.

    Inspired Riding Podcast

    Play Episode Listen Later Feb 27, 2026 62:37


    Want to share your thoughts about the podcast? Text a Message!Welcome to the Animal Wisdom SeriesFeaturing Jana Wagner, Animal Communicator.Episode 9:  Advice from a Zen Master. A conversation with Peppermint.Spotlight: "Peppermint" One of Jana's Feline Family MembersLearn directly from Peppermint about how to property interact with a cat, advice on how to find your stillness to get direct assistance from your feline friends, and why it seems like your cats teleport.... Spoiler Alert: They do! Peppermint shares some profound insights that are not to be missed! One of my favorites: "The purr frequency is designed to give the cells a call to action." Enjoy!! Jana Wagner works with both animals and people as an animal communicator. She also does holistic energy work, is a spiritual director, and Associate Practitioner in Equine Positional Release.She works with all species of animals, including a racoon and geckos! Jana has been an Equestrian since the age of 8 when she took her first riding lesson.You can find her here: https://www.facebook.com/jwagnerancommand IG here: https://www.instagram.com/janawanimalcommunicator/Please leave a review and share this with friends, if you enjoyed this episode! Thank you so much for listening and...

    iOS Today (Video HI)
    iOS 791: Our Favorite Indie Apps - Spotlighting the App Store's Hidden Gems

    iOS Today (Video HI)

    Play Episode Listen Later Feb 26, 2026 32:57


    Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

    iOS Today (MP3)
    iOS 791: Our Favorite Indie Apps - Spotlighting the App Store's Hidden Gems

    iOS Today (MP3)

    Play Episode Listen Later Feb 26, 2026


    Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

    All TWiT.tv Shows (MP3)
    iOS Today 791: Our Favorite Indie Apps

    All TWiT.tv Shows (MP3)

    Play Episode Listen Later Feb 26, 2026 32:57


    Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

    iOS Today (Video)
    iOS 791: Our Favorite Indie Apps - Spotlighting the App Store's Hidden Gems

    iOS Today (Video)

    Play Episode Listen Later Feb 26, 2026 32:57


    Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

    Your Intended Message
    Right Speaker, Right Audience, Right Time: Martin Perelmuter

    Your Intended Message

    Play Episode Listen Later Feb 26, 2026 33:28


    Head & Heart: The Formula for Audience Connection Motivation vs. Information: What Makes a Great Speaker? Episode 294 (Martin is based in Toronto) In this conversation with Martin Peremuter we explore: how evergreen topics like leadership and trust continue to anchor conferences why AI dominates current conference agendas what an audience can realistically apply from a one-hour keynote the balance between information and motivation why sleeping audiences don't learn how cultural differences affect speaking styles and expectations the strategic value of the pre-event call why the gig starts before stepping on stage how integrity off stage affects booking success how to connect with both analytical and emotional audience members why audience interaction must be earned how conference organizers should define purpose and desired behavior change ----- About our guest, Martin Permuter: Martin is the president and co-founder of Speaker's Spotlight, a speaker booking agency.  He has personally booked over 9,000 speaking engagements in the past 30 years. He served on the board of governors of the International Association of Speakers Bureaus, (IASB) for the past three years and was president last year. IASB's membership is made up of speakers' bureaus, lecture agencies, and speaker management companies from around the world.  Learn more about Martin and Speaker's Spotlight at https://www.speakers.ca/ ----- Key lessons from this conversation with Martin Perelmuter: leadership, communication, trust, and teamwork remain evergreen topics AI is currently in demand, while trends like social media rise and fade an audience realistically applies one or two ideas from an hour keynote speakers must balance valuable content with engagement sleeping audiences don't learn cultural expectations influence how speakers are received the pre-event call is critical to customizing the message the gig starts before the speaker steps on stage speakers are judged on integrity both on and off stage the best speakers connect with both head and heart audience trust must be earned before asking for interaction conference organizers must start with why and define the desired behavior change ----- ----more---- Your Intended Message is the podcast about how you can boost your career and business success by honing your communication skills. We'll examine the aspects of how we communicate one-to-one, one to few and one to many – plus that important conversation, one to self. In these interviews we will explore presentation skills, public speaking, conversation, persuasion, negotiation, sales conversations, marketing, team meetings, social media, branding, self talk and more.   Your host is George Torok George is a specialist in communication skills. Especially presentation. He's fascinated by the links between communication and influencing behaviors. He delivers training and coaching programs to help leaders and promising professionals deliver the intended message for greater success.   Connect with George www.SpeechCoachforExecutives.com https://superiorpresentations.net/ https://www.linkedin.com/in/georgetorokpresentations/ https://www.youtube.com/user/presentationskill      

    Mission Matters Podcast with Adam Torres
    Tanya Memme on Confidence, Camera Presence, & Mastering the Spotlight

    Mission Matters Podcast with Adam Torres

    Play Episode Listen Later Feb 26, 2026 10:44


    In this episode, Adam Torres interviews Tanya Memme, Award-Winning TV Host & Founder of Mastering the Spotlight, live from a WEConnect LA event in downtown Los Angeles. Tanya shares her journey in television, her mission to help entrepreneurs gain confidence on camera, and how mastering both AI and authentic human presence is key to building a standout personal brand. About Tanya Memme Tanya Memme is an Emmy‑nominated, award‑winning TV Host, former Miss Canada, and sought‑after Keynote Speaker who has spent more than 25 years on national television, inspiring millions worldwide. Seen on A&E, FYI, TLC, BIO, ABC, CBS, Hallmark Channel, FOX, Disney, BBC, and Netflix. Tanya is known for her warmth, emotional truth, and unmatched storytelling presence. Follow Adam on Instagram at https://www.instagram.com/askadamtorres/ for up to date information on book releases and tour schedule. Apply to be a guest on our podcast: https://missionmatters.lpages.co/podcastguest/ Visit our website: https://missionmatters.com/ More FREE content from Mission Matters here: https://linktr.ee/missionmattersmedia Learn more about your ad choices. Visit podcastchoices.com/adchoices

    ASCO Guidelines Podcast Series
    Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer Guideline Update

    ASCO Guidelines Podcast Series

    Play Episode Listen Later Feb 26, 2026 28:55


    Dr. Lakshmi Rajdev and Dr. Manish Shah join the podcast to discuss the updated guideline on immunotherapy and targeted therapy in unresectable locally advanced, advanced, or metastatic gastroesophageal cancer. They share first-line and subsequent-line recommendations for both gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma based on actionable biomarkers including PD-L1 expression, MMR and/or MSI, CLDN18.2 expression, and HER2 status. They note the importance of the algorithms and tables in the guidelines that provide visual illustrations and quick reference guides of the evidence-based recommendations. They also comment on ongoing and recently presented trials that may impact future guidelines in this space. Read the full guideline, "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update" at www.asco.org/gastrointestinal-cancer-guidelines" TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/gastrointestinal-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02958      Timestamps ·       00:00 – 02:15 Introduction and Overview ·       02:16 - 08:20 First-line treatment for patients with pMMR/MSS, HER2-negative gastroesophageal adenocarcinoma ·       08:21 –10:29 First-line treatment for patients with pMMR/MSS, HER2-positive gastroesophageal adenocarcinoma ·       10:30 – 14:39 First-line treatment for patients with dMMR/MSI-H, gastroesophageal adenocarcinoma ·       14:40 – 18:03 First-line treatment for ESCC ·       18:04 – 22:04 Second- and third-line therapy for gastroesophageal adenocarcinoma and ESCC ·       22:05 – 24:38 Importance of guideline ·       24:39 – 27:45 Outstanding questions and future research   Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts.   My name is Brittany Harvey, and today I am interviewing Dr. Lakshmi Rajdev from the Icahn School of Medicine at Mount Sinai and Dr. Manish Shah from Weill Cornell Medicine, co-chairs on "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update." Thank you for being here today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you for having us. It is wonderful. Brittany Harvey: And then just before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Rajdev and Dr. Shah, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into what we are here today to talk about, Dr. Shah, I would like to start first with what prompted the update to this guideline, which was previously published in 2023, and what is the scope of this updated guideline? Dr. Manish Shah: Yes, terrific. So even in the last few years, the pace of drug development in gastroesophageal cancers has just been astounding. So, what prompted this guideline is actually the practice-changing results for a new biomarker, CLDN18.2 hat was based on the GLOW and SPOTLIGHT studies, as well as a practice-changing study in HER2-positive disease where we added pembrolizumab to trastuzumab and chemotherapy for tumors that are HER2-positive and PD-L1 CPS 1 or greater. And then there were also new studies and new approvals in esophageal squamous cell cancer that you will hear about as well. So there were several studies, overall more than 5,000 patients were reported on, and that led to several new therapies, new indications, and it really necessitated this guideline. Brittany Harvey: Excellent. It is great to hear about all of these exciting updates in this space. So then to next review the key recommendations of this guideline by clinical question that the expert panel addressed. So, Dr. Rajdev, what is the recommended first-line treatment for patients with proficient mismatch repair, microsatellite stable, HER2-negative gastroesophageal adenocarcinoma? Dr. Lakshmi Rajdev: Thank you for that question. So historically, we have sort of used fluoropyrimidine and platinum doublets, which yielded a survival of about one year. More recently, immunotherapy and targeted therapy options have improved outcomes in patients with advanced esophageal and gastric adenocarcinoma, as well as squamous cell carcinoma. Patients with gastric and GE junction adenocarcinoma have a high rate of actionable alterations, so it is imperative that physicians test the following biomarkers upfront so that it can help guide therapy. The markers recommended by the ASCO panel are HER2, MMR or MSI, CLDN18.2, and PD-L1. And also, it was recommended to use NGS if feasible in this patient population. HER2, as we know, is expressed in about 15% to 25% of patients; PD-L1 expression occurs in about 80% of patients; MSI-high, deficient MMR is present in about 5% to 8% of patients; and CLDN18.2 expression is present in about 40% of patients. There is, of course, biomarker overlap. About 13% to 22% of CLDN18.2 patients are also PD-L1 positive. For patients with pMMR or microsatellite stable HER2-negative disease with PD-L1 expression greater than 1 and absence of CLDN18.2, the panel recommended a first-line therapy with fluoropyrimidine and platinum-based therapy in combination with immunotherapy. These recommendations stem from large phase 3 trials, and the agents approved in the United States are pembrolizumab, nivolumab, and tislelizumab. It has been shown that immunotherapy benefit is greater in patients with higher PD-L1 expression, and it is not possible to comment on the individual PD-L1 cutoff scores and sort of identify the optimal PD-L1 cutoff score that sort of balances benefits and harms. But what is recommended is that immunotherapy-based treatments can be offered in patients with a CPS score of greater than 1. With regard to the choice of immunotherapy agents, that is pembrolizumab, nivolumab, or tislelizumab, these agents are considered to have similar efficacy, and the selection of an agent could be based on dosing schedule, cost considerations, toxicity, and the method of administration. Typically, clinicians should avoid withholding the start of chemotherapy while awaiting biomarker testing, depending on the clinical scenario. Now, for patients with pMMR microsatellite stable disease that is HER2-negative with PD-L1 expression less than 1 and positive CLDN18.2 expression, zolbetuximab-based treatments or in combination with chemotherapy is recommended, and this is based on two global phase III randomized controlled trials, the GLOW and the SPOTLIGHT. And across both studies, the hazard ratio for the overall survival was 0.78, and similarly, there was also an improvement in progression-free survival favoring the zolbetuximab group compared to the chemotherapy group alone. An important note is that nausea, vomiting is commonly associated with zolbetuximab-based treatments, and the panel recommended prophylactic antiemetics, adjusting zolbetuximab infusion rates, pausing infusion temporarily, using non-prophylactic antiemetics, and hydration intravenously prior to discontinuation of zolbetuximab-based chemotherapy. So effective handling of the GI-related symptoms with zolbetuximab is recommended prior to discontinuation of therapy. Now, for patients with pMMR microsatellite stable HER2-negative gastric, GE junction adenocarcinoma with PD-L1 expression greater than 1 and CLDN18.2 positivity, the ones with the dual expression with CLDN18.2 as well as PD-L1 chemotherapy, the choice of therapy can be based on the degree of PD-L1 expression, the toxicity profile, the burden of symptoms, and the anticipated improvement in symptoms associated with response to treatment, the patient comorbidities, the prior medical and treatment history. So this decision needs to be made on a case-by-case basis, and these are some of the factors that we suggested that could potentially influence the choice of therapy. For patients with pMMR microsatellite stable disease that is HER2-negative and a PD-L1 expression less than 1 and an absence of CLDN18.2 expression, first-line therapy with fluoropyrimidine and platinum-based chemotherapy is recommended. So you can see we have segmented out patients based on PD-L1 expression, pMMR and microsatellite stable disease expression, and also based on CLDN expression. Brittany Harvey: Absolutely. And that first point you noted, I think is really important, that biomarker testing is really critical for treatment decision-making in this space. So then the next subgroup of patients that the panel looked at, Dr. Shah, what first-line therapy is recommended for patients with proficient mismatch repair, microsatellite stable, HER2-positive gastroesophageal adenocarcinoma? Dr. Manish Shah: So this was an update from a few years ago. So we have known for 15 years now that if you are HER2-positive, you should get trastuzumab plus chemotherapy. That was based on the ToGA trial. And the update now is based on a trial called KEYNOTE-811, where it examined the addition of pembrolizumab to trastuzumab and chemotherapy versus trastuzumab and chemotherapy, and there was a progression-free and overall survival benefit. And again, here, the biomarkers are important. If your CPS PD-L1 is less than 1, we would not recommend Pembrolizumab in that setting, so you would still get trastuzumab and chemotherapy. But if it is 1 or greater, the PD-L1 CPS score, then we do recommend pembrolizumab unless there is a contraindication to immunotherapy. The take-home message really is from the onset of diagnosis, please check your biomarkers. And I will just, it is worth repeating, it is important to check your PD-L1 status, HER2 status, mismatch repair status, and CLDN18.2 status. And then the optimal therapy, and it is outlined in the publication, is really biomarker-driven. We know that if we are able to hit the target that is overexpressed, we are going to have a better outcome. And Dr. Rajdev did mention where there is overlap, there can be a lack of data, and that is where we are with both PD-L1 positive and CLDN positive. Here we do have data in HER2-positive cases where if you are both HER2-positive and PD-L1 positive, you would combine trastuzumab and pembrolizumab for the best outcomes. Brittany Harvey: Understood. I really appreciate you detailing what is most important for each individual biomarker combination that patients may have. So then following that, Dr. Rajdev, what does the expert panel recommend for first-line treatment for patients with esophageal squamous cell carcinoma that is not amenable to definitive chemoradiation? Dr. Lakshmi Rajdev: There are three phase III randomized clinical trials that have influenced practice in patients with esophageal squamous cell carcinoma examining the benefit of immunotherapy in this patient population. The RATIONALE-306 was a randomized trial of tislelizumab plus chemotherapy with platinum and fluoropyrimidine or paclitaxel versus placebo with chemotherapy. And then you have the KEYNOTE-590, which compared pembrolizumab plus chemotherapy versus chemotherapy alone. And then you have CheckMate-648, which included comparisons of nivolumab plus chemotherapy versus nivolumab plus ipilimumab or chemotherapy. And the primary endpoints for these studies were overall survival, and they did look at subgroups with PD-L1 expression. They used TPS score greater than 1% in CheckMate-648 and PD-L1 CPS greater than 10 in KEYNOTE-590. The bottom line is that the overall hazard ratio for overall survival across this patient population was 0.72. So clearly, there is benefit in patients that express PD-L1 CPS greater than 1 for benefit for the addition of immunotherapy. Now, the benefit again in patients with a PD-L1 expression less than 1 remains limited, and so the panel has made a recommendation for using immunotherapy in combination with platinum-based chemotherapy in patients with a PD-L1 greater than 1. Again, we know that it is hard to make recommendations on what PD-L1 cutoffs are recommended in this patient population, meaning that should it be limited to patients with a PD-L1 of 1 to 4 or greater than 10? I think that the general consensus that has been gleaned from the data is that the higher the PD-L1 expression, the greater the benefit. I do want to comment on another option that is available in patients with squamous cell carcinoma compared to adenocarcinoma, and that is the combination of nivolumab and ipilimumab. Now, in CheckMate-648, nivolumab with ipilimumab was also recommended as a treatment option in patients that have a PD-L1 score of greater than 1. There was a survival benefit demonstrated with this combination compared to chemotherapy alone. And an important observation in this study is that, although there was a slightly increased rate in early death, but there was really no significant difference in PFS and OS compared to chemotherapy alone. Importantly, the treatment appeared to be pretty well tolerated by the study population. There was a notable difference in the objective response rate, which was 35% in the nivolumab plus ipilimumab group compared to patients receiving nivolumab and chemotherapy, where it was 53%. So superiority is, so the importance of chemotherapy in patients with esophageal squamous cell carcinoma is to be noted. However, there is no difference in overall survival and progression-free survival when using the combination of nivolumab and ipilimumab, and thus it affords a chemotherapy-free option for this patient population with esophageal squamous cell carcinoma and a CPS with a score of greater than 1. Brittany Harvey: Understood. I appreciate you reviewing the evidence underpinning those recommendations as well. So then the next patient population that the guideline panel addressed, what first-line therapy is recommended for patients with deficient mismatch repair, microsatellite instability-high, gastroesophageal adenocarcinoma or esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: The rate of MSI-high expression is about 3% to 7% across different studies. Now, the KEYNOTE-158 was a tumor-agnostic study in patients with non-colorectal cancers, and again, the problem with the MSI-high population, given that it is so rare, the numbers in the individual studies are fairly small. But consistent outcomes do emerge, indicating high response to immunotherapy. So in KEYNOTE-158, a response rate of about 46% was noted. The number of patients was small, it was about 24. In CheckMate-649, which is a study of chemotherapy plus or minus nivolumab in patients with advanced gastric adenocarcinoma, there was again a very small number of patients, and patients that were MSI-high or deficient MMR did experience substantial benefits with the addition of immunotherapy, with hazard ratios in the order of about 0.38. In KEYNOTE-062, again, it was a very small number of patients, again about 6% or so, and similar to CheckMate-649, a substantial benefit was noted in combination with chemotherapy, but also there were benefits noted with pembrolizumab alone. The RATIONALE-305 again was a study of tislelizumab in combination with chemotherapy and similarly showed benefits to the combination of chemotherapy plus immunotherapy in this patient population. I think that we are all aware of the dramatic benefits of immunotherapy in this particular subset of patients, deficient MMR MSI-high, and also we have seen in CheckMate-649 they did have a subset of patients that received nivolumab and ipilimumab. And in this patient population, they noted unstratified hazard ratio of 0.28. So I think that the overall consensus is that immunotherapy is a very important treatment modality in patients with deficient MMR MSI-high disease, given that a lot of the trials in gastroesophageal adenocarcinoma have utilized chemotherapy-based options, that is certainly a recommendation of the panel to use chemotherapy in combination with immunotherapy. However, on a case-by-case basis, the panel recommended immunotherapy alone as well, and given the high response rates noted in trials across different diseases as well as noted in this disease as well. Brittany Harvey: Certainly. And I appreciate you both for reviewing these first-line recommendations. So moving to later lines of therapy, Dr. Rajdev, what recommendations did the expert panel make for second or third-line therapy for gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: So, I think that the RAINBOW trial that investigated the utility of the addition of ramucirumab as second-line therapy has been around since 2014, and those results have led to the addition of ramucirumab to taxane-based therapy in the second-line setting. Based on the utilization of oxaliplatin and platinum-based therapy in the front-line setting, there may be patients that have an underlying neuropathy, and so we wanted to really include treatment options for this patient population so that an agent that is less neurotoxic could also be recommended in combination with ramucirumab. The RAMIRIS trial is one such trial where ramucirumab was combined with FOLFIRI, and it demonstrated benefit in combination with ramucirumab. So we have listed that as a potential treatment option for patients in the second-line setting who may have an underlying neuropathy or even for whatever reason that based on the toxicity profile, that needs to be the preferred option by a physician, that recommendation is new from the older guidelines that we have. With regard to the utility of PD-1 inhibitors, there really has been no benefit noted in the second-line setting with regard to overall survival or progression-free survival, so no recommendation is made for that option. I think an important study that has been recently presented is the DESTINY-Gastric04 trial, which really has been practice-changing and has led to the recommendation for trastuzumab deruxtecan in patients that have HER2-positive metastatic gastric or GE junction adenocarcinoma. Now, this is a phase III trial in patients who retained HER2-positive disease after progressing on front-line trastuzumab-based treatments, and the comparator for this trial was trastuzumab deruxtecan versus ramucirumab plus paclitaxel. There was significant improvement and progression-free survival in patients that received trastuzumab deruxtecan. The patients that were excluded from the trial are patients that have pulmonary problems, interstitial lung disease; that is one of the toxicities of this particular agent, and close monitoring and prompt initiation of therapy such as glucocorticoid treatment in patients who develop this toxicity was also highlighted by the panel. So to summarize, the new guidelines highlight the possibility of FOLFIRI plus ramucirumab as a second-line option and then trastuzumab deruxtecan as a later-line option in patients that still retain HER2 expression. And that is very important because the trial did retest patients whether they expressed HER2. As we know, in a substantial number of patients, there is downregulation of HER2, and there is emerging data that the benefit for subsequent HER2-directed therapies is best noted in patients that still retain HER2 expression. Brittany Harvey: Great. So as our listeners have heard, there are many recommendations and new treatment options for advanced gastroesophageal cancer. Dr. Shah, earlier you highlighted the importance of biomarker testing, but I would like to hear in your view, what is the importance of this guideline and how will it impact both clinicians and patients with gastroesophageal carcinoma? Dr. Manish Shah: So as we have discussed throughout this podcast, the treatment for gastroesophageal cancer, both adenocarcinoma and squamous cell cancer, is increasingly complex, increasingly biomarker-driven. And I think the value of the guideline is to place all of that into context. So it provides the data for why certain biomarkers are important, what therapies should be indicated. Not only that, but if you are able to review the guideline, it provides the details of each of these studies and summarizes them in a meta-analysis fashion to sort of give you the context, because sometimes the individual studies can be maybe a little bit discordant or confusing and the guideline attempts to harmonize all that. And then also, I think the tables are very, very interesting because they give you actual numbers in terms of how many patients over a thousand would this benefit or how many patients over a thousand would this cause harm in terms of nausea, vomiting, or other things like that. So it gives you context for helping clinicians and patients weigh the potential benefits of the novel treatment strategies against the potential adverse events. And then finally, the guideline does also provide an algorithm that you are able to follow based on the biomarkers, and those are in figures 4 and 5. So I think overall, it is a very comprehensive guideline. It intends to make more manageable a very complex subject, and you know, I really encourage our listeners to review it after listening to the podcast. Dr. Lakshmi Rajdev: If I can add to that, I think that what is also really good about the guidelines is there are quick summaries. So if someone is busy in the clinic, of course, there is the opportunity to review the data supporting the guidelines in great depth in the manuscript, but what is also really good is that there are good summaries. In the event that you are very busy, you can easily identify what the recommendations should be for that particular patient based on these summaries. Brittany Harvey: Absolutely. Listeners are encouraged to review the full guideline, including those tables and figures that may be more helpful when they are looking for something quick to look at in the clinic as well. So, as you both mentioned, there have been a number of recent practice-changing trials in this area. So I imagine there is still a lot of ongoing research as well. So Dr. Shah, what are the outstanding questions regarding treatment options for patients with locally advanced unresectable, advanced, or metastatic gastroesophageal carcinoma? Dr. Manish Shah: I think we touched upon it a little bit. The guidelines are based on the data available, and they are primarily examining one novel therapy with chemotherapy in a specific biomarker population. But as you know, the biomarkers are not either/or; you are not either CLDN18.2 positive or PD-L1 positive. A portion of patients could have dual biomarkers, and you know, I think that we are generating data on how to manage those patients. At the recent GI Symposium in January this year, the ILUSTRO trial was presented by Dr. Shitara, which looked at combining zolbetuximab and chemotherapy with immunotherapy for dual-positive biomarkers, and that is leading to a phase III study that has begun to enroll. So unanswered questions are: how do we manage dual-positive biomarkers? The other thing that was mentioned is that the current data for mismatch repair deficiency involve chemotherapy plus immunotherapy. Only squamous cell cancer is there a study with a positive non-chemotherapy kind of backbone, that is CheckMate-648 that Dr. Rajdev mentioned. As we move forward, it will be good to get data on non-chemotherapy options in certain biomarker-positive populations. And then finally, another update, which is likely to be practice-changing, is the HERIZON-GEA-01 study that looked at zanidatamab, which is another biparatopic antibody that targets HER2, and that is likely to change practice. And as that data gets published, we may look to even do a rapid update for the current immunotherapy and targeted therapy guideline that is just being published. Dr. Lakshmi Rajdev: So, if I can add to that, there are numerous ADCs that look very interesting. There are bispecific antibodies; in fact, the zanidatamab is a bispecific antibody showing improved activity in patients with HER2-positive disease. So I think there are studies from Asia looking at CLDN CAR T-based therapies. So, I think that there are a lot of novel agents and a lot of excitement in the field. We know that the bemarituzumab study, unfortunately, the FGFR2 inhibitor failed to demonstrate any benefit, but I think that there are other agents that are being explored, so there are newer targets, newer agents, ADCs, bispecifics that could potentially change the field in the future. Brittany Harvey: Yes, we will look forward to the data to address these unanswered questions and new agents and inform future guideline updates. So, I would like to thank you both for all of your work to review the evidence here and update this important guideline, and for your time today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

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    Play Episode Listen Later Feb 26, 2026 14:23


    Pastor Tonya Marks helps our new host, Mark Bocci, warm up to the mic as he shares some of his ideas for Spotlight on Grace!

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    Play Episode Listen Later Feb 26, 2026 32:57 Transcription Available


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    Play Episode Listen Later Feb 25, 2026 10:54 Transcription Available


    Roger Basick and Marina Santee tell about how a small Texas town became very popular because a young couple had the courage to chase after their dreams.https://spotlightenglish.com/uncategorized/chasing-dreams-all-the-way-to-waco/Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

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    Play Episode Listen Later Feb 24, 2026 58:15


    Woman's Hour in collaboration with our SEND in the Spotlight podcast brings you a special programme on the impact of the government's SEND reforms in England.Whether you're a parent, a young person, a teacher or someone who works in the wider system we find out what the changes mean for you - and help you decode the new language - whether it's IB, ISP, Targeted, Targeted Plus, or SPP. Nuala McGovern speaks to parents, teachers, charities, the School Standards Minister and the Children's Commissioner for England. We also hear from SEND in the Spotlight podcast regulars - actors Anna Maxwell Martin and Kellie Bright.Search for the SEND in the Spotlight podcast on BBC Sounds.Contributors: Georgia Gould MP, Schools Standards Minister Marsha Martin, founder of Black SEN Mamas Katie Ghose, CEO of Kids charity and Disabled Children's Partnership Margaret Mulholland, Association of School and College Leaders Kate McGough, BBC Education reporter Eleanor Wright, solicitor at SOS!SEN Ramandeep Kaur, SEND parent Carrie Grant, SEND parent and broadcaster Katie Nellist, SEND ambassador Louise Gittins, chair of the Local Government Association Dame Rachel de Souza, Children's Commissioner for EnglandPresenter: Nuala McGovern Producer: Sarah Crawley, with Carolyn Atkinson Digital producer: Olivia Bolton Editor: Karen Dalziel