Podcasts about Spotlight

Diana Brandl is a longtime C-Suite assistant, and host of the Executive Office Insights podcast.In this spotlight episode, Diana speaks with Lauren Bradley about how EAs can thrive.Show Notes -> leaderassistant.com/365 --It's the last day of the offsite and it was exactly what the team needed. The CEO pulls you aside to say, “Thank you. This was next level.”Your secret? You used Offsite. They handled the venues, negotiations, and logistics – so you could focus on shaping the experience.Sound too good to be true? It's actually within reach. (And it can even save you money.)See how at leaderassistant.com/offsite. --Are you ready to level up? Enroll in The Leader Assistant Academy at leaderassistant.com/academy to embrace the Leader Assistant frameworks used by thousands of assistants.More from The Leader Assistant... Book, Audiobook, and Workbook -> leaderassistantbook.com The Leader Assistant Academy -> leaderassistantbook.com/academy Premium Membership -> leaderassistant.com/membership Events -> leaderassistantlive.com Free Community -> leaderassistant.com/community

A 40-year career retrospective of Dame Tracey Emin's work has opened at the Tate Modern in London, featuring many of the artist's most iconic pieces, from her controversial, Turner Prize shortlisted My Bed (1998) to her neon artworks, textiles, bronze sculptures, photos, and paintings. Called A Second Life, it explores the connections and tensions between her early career and the work she's created since 2020, when she was diagnosed with cancer and underwent a huge operation. Tracey joins Anita Rani to discuss her body of work.Student midwives have contacted us to say many of them are struggling to find jobs despite a serious shortage of midwives in the NHS. A new survey from the Royal College of Midwives finds 31% of newly qualified midwives are still not employed in the role, and the majority of those who have found employment are on fixed-term contracts. Nuala McGovern hears from Safia, who is in her final year of midwifery training, and Gill Walton, Chief Executive of the Royal College of Midwives.Molly vs the Machines is a new feature-length documentary that tells the story of Ian Russell and his fight for online safety after his daughter Molly took her own life in 2017 following months of viewing content relating to self-harm and suicide on social media. Molly's friends Charlotte Campbell and Sophie Conlan tell Anita why it was important for them to take part in the film.In collaboration with our Send in the Spotlight podcast, Nuala speaks to Schools Standards Minister Georgia Gould about the government's proposed SEND reforms.Writer and actor Kyla Harris joins Clare McDonnell to discuss reframing disability with her acclaimed BBC comedy We Might Regret This, which she co-created.Presenter: Anita Rani Producer: Dianne McGregor

Want to share your thoughts about the podcast? Text a Message!Welcome to the Animal Wisdom SeriesFeaturing Jana Wagner, Animal Communicator.Episode 9:  Advice from a Zen Master. A conversation with Peppermint.Spotlight: "Peppermint" One of Jana's Feline Family MembersLearn directly from Peppermint about how to property interact with a cat, advice on how to find your stillness to get direct assistance from your feline friends, and why it seems like your cats teleport.... Spoiler Alert: They do! Peppermint shares some profound insights that are not to be missed! One of my favorites: "The purr frequency is designed to give the cells a call to action." Enjoy!! Jana Wagner works with both animals and people as an animal communicator. She also does holistic energy work, is a spiritual director, and Associate Practitioner in Equine Positional Release.She works with all species of animals, including a racoon and geckos! Jana has been an Equestrian since the age of 8 when she took her first riding lesson.You can find her here: https://www.facebook.com/jwagnerancommand IG here: https://www.instagram.com/janawanimalcommunicator/Please leave a review and share this with friends, if you enjoyed this episode! Thank you so much for listening and...

Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Rosemary Orchard Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

Head & Heart: The Formula for Audience Connection Motivation vs. Information: What Makes a Great Speaker? Episode 294 (Martin is based in Toronto) In this conversation with Martin Peremuter we explore: how evergreen topics like leadership and trust continue to anchor conferences why AI dominates current conference agendas what an audience can realistically apply from a one-hour keynote the balance between information and motivation why sleeping audiences don't learn how cultural differences affect speaking styles and expectations the strategic value of the pre-event call why the gig starts before stepping on stage how integrity off stage affects booking success how to connect with both analytical and emotional audience members why audience interaction must be earned how conference organizers should define purpose and desired behavior change ----- About our guest, Martin Permuter: Martin is the president and co-founder of Speaker's Spotlight, a speaker booking agency.  He has personally booked over 9,000 speaking engagements in the past 30 years. He served on the board of governors of the International Association of Speakers Bureaus, (IASB) for the past three years and was president last year. IASB's membership is made up of speakers' bureaus, lecture agencies, and speaker management companies from around the world.  Learn more about Martin and Speaker's Spotlight at https://www.speakers.ca/ ----- Key lessons from this conversation with Martin Perelmuter: leadership, communication, trust, and teamwork remain evergreen topics AI is currently in demand, while trends like social media rise and fade an audience realistically applies one or two ideas from an hour keynote speakers must balance valuable content with engagement sleeping audiences don't learn cultural expectations influence how speakers are received the pre-event call is critical to customizing the message the gig starts before the speaker steps on stage speakers are judged on integrity both on and off stage the best speakers connect with both head and heart audience trust must be earned before asking for interaction conference organizers must start with why and define the desired behavior change ----- ----more---- Your Intended Message is the podcast about how you can boost your career and business success by honing your communication skills. We'll examine the aspects of how we communicate one-to-one, one to few and one to many – plus that important conversation, one to self. In these interviews we will explore presentation skills, public speaking, conversation, persuasion, negotiation, sales conversations, marketing, team meetings, social media, branding, self talk and more.   Your host is George Torok George is a specialist in communication skills. Especially presentation. He's fascinated by the links between communication and influencing behaviors. He delivers training and coaching programs to help leaders and promising professionals deliver the intended message for greater success.   Connect with George www.SpeechCoachforExecutives.com https://superiorpresentations.net/ https://www.linkedin.com/in/georgetorokpresentations/ https://www.youtube.com/user/presentationskill      

In this episode, Adam Torres interviews Tanya Memme, Award-Winning TV Host & Founder of Mastering the Spotlight, live from a WEConnect LA event in downtown Los Angeles. Tanya shares her journey in television, her mission to help entrepreneurs gain confidence on camera, and how mastering both AI and authentic human presence is key to building a standout personal brand. About Tanya Memme Tanya Memme is an Emmy‑nominated, award‑winning TV Host, former Miss Canada, and sought‑after Keynote Speaker who has spent more than 25 years on national television, inspiring millions worldwide. Seen on A&E, FYI, TLC, BIO, ABC, CBS, Hallmark Channel, FOX, Disney, BBC, and Netflix. Tanya is known for her warmth, emotional truth, and unmatched storytelling presence. Follow Adam on Instagram at https://www.instagram.com/askadamtorres/ for up to date information on book releases and tour schedule. Apply to be a guest on our podcast: https://missionmatters.lpages.co/podcastguest/ Visit our website: https://missionmatters.com/ More FREE content from Mission Matters here: https://linktr.ee/missionmattersmedia Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Lakshmi Rajdev and Dr. Manish Shah join the podcast to discuss the updated guideline on immunotherapy and targeted therapy in unresectable locally advanced, advanced, or metastatic gastroesophageal cancer. They share first-line and subsequent-line recommendations for both gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma based on actionable biomarkers including PD-L1 expression, MMR and/or MSI, CLDN18.2 expression, and HER2 status. They note the importance of the algorithms and tables in the guidelines that provide visual illustrations and quick reference guides of the evidence-based recommendations. They also comment on ongoing and recently presented trials that may impact future guidelines in this space. Read the full guideline, "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update" at www.asco.org/gastrointestinal-cancer-guidelines" TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/gastrointestinal-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02958      Timestamps ·       00:00 – 02:15 Introduction and Overview ·       02:16 - 08:20 First-line treatment for patients with pMMR/MSS, HER2-negative gastroesophageal adenocarcinoma ·       08:21 –10:29 First-line treatment for patients with pMMR/MSS, HER2-positive gastroesophageal adenocarcinoma ·       10:30 – 14:39 First-line treatment for patients with dMMR/MSI-H, gastroesophageal adenocarcinoma ·       14:40 – 18:03 First-line treatment for ESCC ·       18:04 – 22:04 Second- and third-line therapy for gastroesophageal adenocarcinoma and ESCC ·       22:05 – 24:38 Importance of guideline ·       24:39 – 27:45 Outstanding questions and future research   Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts.   My name is Brittany Harvey, and today I am interviewing Dr. Lakshmi Rajdev from the Icahn School of Medicine at Mount Sinai and Dr. Manish Shah from Weill Cornell Medicine, co-chairs on "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update." Thank you for being here today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you for having us. It is wonderful. Brittany Harvey: And then just before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Rajdev and Dr. Shah, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into what we are here today to talk about, Dr. Shah, I would like to start first with what prompted the update to this guideline, which was previously published in 2023, and what is the scope of this updated guideline? Dr. Manish Shah: Yes, terrific. So even in the last few years, the pace of drug development in gastroesophageal cancers has just been astounding. So, what prompted this guideline is actually the practice-changing results for a new biomarker, CLDN18.2 hat was based on the GLOW and SPOTLIGHT studies, as well as a practice-changing study in HER2-positive disease where we added pembrolizumab to trastuzumab and chemotherapy for tumors that are HER2-positive and PD-L1 CPS 1 or greater. And then there were also new studies and new approvals in esophageal squamous cell cancer that you will hear about as well. So there were several studies, overall more than 5,000 patients were reported on, and that led to several new therapies, new indications, and it really necessitated this guideline. Brittany Harvey: Excellent. It is great to hear about all of these exciting updates in this space. So then to next review the key recommendations of this guideline by clinical question that the expert panel addressed. So, Dr. Rajdev, what is the recommended first-line treatment for patients with proficient mismatch repair, microsatellite stable, HER2-negative gastroesophageal adenocarcinoma? Dr. Lakshmi Rajdev: Thank you for that question. So historically, we have sort of used fluoropyrimidine and platinum doublets, which yielded a survival of about one year. More recently, immunotherapy and targeted therapy options have improved outcomes in patients with advanced esophageal and gastric adenocarcinoma, as well as squamous cell carcinoma. Patients with gastric and GE junction adenocarcinoma have a high rate of actionable alterations, so it is imperative that physicians test the following biomarkers upfront so that it can help guide therapy. The markers recommended by the ASCO panel are HER2, MMR or MSI, CLDN18.2, and PD-L1. And also, it was recommended to use NGS if feasible in this patient population. HER2, as we know, is expressed in about 15% to 25% of patients; PD-L1 expression occurs in about 80% of patients; MSI-high, deficient MMR is present in about 5% to 8% of patients; and CLDN18.2 expression is present in about 40% of patients. There is, of course, biomarker overlap. About 13% to 22% of CLDN18.2 patients are also PD-L1 positive. For patients with pMMR or microsatellite stable HER2-negative disease with PD-L1 expression greater than 1 and absence of CLDN18.2, the panel recommended a first-line therapy with fluoropyrimidine and platinum-based therapy in combination with immunotherapy. These recommendations stem from large phase 3 trials, and the agents approved in the United States are pembrolizumab, nivolumab, and tislelizumab. It has been shown that immunotherapy benefit is greater in patients with higher PD-L1 expression, and it is not possible to comment on the individual PD-L1 cutoff scores and sort of identify the optimal PD-L1 cutoff score that sort of balances benefits and harms. But what is recommended is that immunotherapy-based treatments can be offered in patients with a CPS score of greater than 1. With regard to the choice of immunotherapy agents, that is pembrolizumab, nivolumab, or tislelizumab, these agents are considered to have similar efficacy, and the selection of an agent could be based on dosing schedule, cost considerations, toxicity, and the method of administration. Typically, clinicians should avoid withholding the start of chemotherapy while awaiting biomarker testing, depending on the clinical scenario. Now, for patients with pMMR microsatellite stable disease that is HER2-negative with PD-L1 expression less than 1 and positive CLDN18.2 expression, zolbetuximab-based treatments or in combination with chemotherapy is recommended, and this is based on two global phase III randomized controlled trials, the GLOW and the SPOTLIGHT. And across both studies, the hazard ratio for the overall survival was 0.78, and similarly, there was also an improvement in progression-free survival favoring the zolbetuximab group compared to the chemotherapy group alone. An important note is that nausea, vomiting is commonly associated with zolbetuximab-based treatments, and the panel recommended prophylactic antiemetics, adjusting zolbetuximab infusion rates, pausing infusion temporarily, using non-prophylactic antiemetics, and hydration intravenously prior to discontinuation of zolbetuximab-based chemotherapy. So effective handling of the GI-related symptoms with zolbetuximab is recommended prior to discontinuation of therapy. Now, for patients with pMMR microsatellite stable HER2-negative gastric, GE junction adenocarcinoma with PD-L1 expression greater than 1 and CLDN18.2 positivity, the ones with the dual expression with CLDN18.2 as well as PD-L1 chemotherapy, the choice of therapy can be based on the degree of PD-L1 expression, the toxicity profile, the burden of symptoms, and the anticipated improvement in symptoms associated with response to treatment, the patient comorbidities, the prior medical and treatment history. So this decision needs to be made on a case-by-case basis, and these are some of the factors that we suggested that could potentially influence the choice of therapy. For patients with pMMR microsatellite stable disease that is HER2-negative and a PD-L1 expression less than 1 and an absence of CLDN18.2 expression, first-line therapy with fluoropyrimidine and platinum-based chemotherapy is recommended. So you can see we have segmented out patients based on PD-L1 expression, pMMR and microsatellite stable disease expression, and also based on CLDN expression. Brittany Harvey: Absolutely. And that first point you noted, I think is really important, that biomarker testing is really critical for treatment decision-making in this space. So then the next subgroup of patients that the panel looked at, Dr. Shah, what first-line therapy is recommended for patients with proficient mismatch repair, microsatellite stable, HER2-positive gastroesophageal adenocarcinoma? Dr. Manish Shah: So this was an update from a few years ago. So we have known for 15 years now that if you are HER2-positive, you should get trastuzumab plus chemotherapy. That was based on the ToGA trial. And the update now is based on a trial called KEYNOTE-811, where it examined the addition of pembrolizumab to trastuzumab and chemotherapy versus trastuzumab and chemotherapy, and there was a progression-free and overall survival benefit. And again, here, the biomarkers are important. If your CPS PD-L1 is less than 1, we would not recommend Pembrolizumab in that setting, so you would still get trastuzumab and chemotherapy. But if it is 1 or greater, the PD-L1 CPS score, then we do recommend pembrolizumab unless there is a contraindication to immunotherapy. The take-home message really is from the onset of diagnosis, please check your biomarkers. And I will just, it is worth repeating, it is important to check your PD-L1 status, HER2 status, mismatch repair status, and CLDN18.2 status. And then the optimal therapy, and it is outlined in the publication, is really biomarker-driven. We know that if we are able to hit the target that is overexpressed, we are going to have a better outcome. And Dr. Rajdev did mention where there is overlap, there can be a lack of data, and that is where we are with both PD-L1 positive and CLDN positive. Here we do have data in HER2-positive cases where if you are both HER2-positive and PD-L1 positive, you would combine trastuzumab and pembrolizumab for the best outcomes. Brittany Harvey: Understood. I really appreciate you detailing what is most important for each individual biomarker combination that patients may have. So then following that, Dr. Rajdev, what does the expert panel recommend for first-line treatment for patients with esophageal squamous cell carcinoma that is not amenable to definitive chemoradiation? Dr. Lakshmi Rajdev: There are three phase III randomized clinical trials that have influenced practice in patients with esophageal squamous cell carcinoma examining the benefit of immunotherapy in this patient population. The RATIONALE-306 was a randomized trial of tislelizumab plus chemotherapy with platinum and fluoropyrimidine or paclitaxel versus placebo with chemotherapy. And then you have the KEYNOTE-590, which compared pembrolizumab plus chemotherapy versus chemotherapy alone. And then you have CheckMate-648, which included comparisons of nivolumab plus chemotherapy versus nivolumab plus ipilimumab or chemotherapy. And the primary endpoints for these studies were overall survival, and they did look at subgroups with PD-L1 expression. They used TPS score greater than 1% in CheckMate-648 and PD-L1 CPS greater than 10 in KEYNOTE-590. The bottom line is that the overall hazard ratio for overall survival across this patient population was 0.72. So clearly, there is benefit in patients that express PD-L1 CPS greater than 1 for benefit for the addition of immunotherapy. Now, the benefit again in patients with a PD-L1 expression less than 1 remains limited, and so the panel has made a recommendation for using immunotherapy in combination with platinum-based chemotherapy in patients with a PD-L1 greater than 1. Again, we know that it is hard to make recommendations on what PD-L1 cutoffs are recommended in this patient population, meaning that should it be limited to patients with a PD-L1 of 1 to 4 or greater than 10? I think that the general consensus that has been gleaned from the data is that the higher the PD-L1 expression, the greater the benefit. I do want to comment on another option that is available in patients with squamous cell carcinoma compared to adenocarcinoma, and that is the combination of nivolumab and ipilimumab. Now, in CheckMate-648, nivolumab with ipilimumab was also recommended as a treatment option in patients that have a PD-L1 score of greater than 1. There was a survival benefit demonstrated with this combination compared to chemotherapy alone. And an important observation in this study is that, although there was a slightly increased rate in early death, but there was really no significant difference in PFS and OS compared to chemotherapy alone. Importantly, the treatment appeared to be pretty well tolerated by the study population. There was a notable difference in the objective response rate, which was 35% in the nivolumab plus ipilimumab group compared to patients receiving nivolumab and chemotherapy, where it was 53%. So superiority is, so the importance of chemotherapy in patients with esophageal squamous cell carcinoma is to be noted. However, there is no difference in overall survival and progression-free survival when using the combination of nivolumab and ipilimumab, and thus it affords a chemotherapy-free option for this patient population with esophageal squamous cell carcinoma and a CPS with a score of greater than 1. Brittany Harvey: Understood. I appreciate you reviewing the evidence underpinning those recommendations as well. So then the next patient population that the guideline panel addressed, what first-line therapy is recommended for patients with deficient mismatch repair, microsatellite instability-high, gastroesophageal adenocarcinoma or esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: The rate of MSI-high expression is about 3% to 7% across different studies. Now, the KEYNOTE-158 was a tumor-agnostic study in patients with non-colorectal cancers, and again, the problem with the MSI-high population, given that it is so rare, the numbers in the individual studies are fairly small. But consistent outcomes do emerge, indicating high response to immunotherapy. So in KEYNOTE-158, a response rate of about 46% was noted. The number of patients was small, it was about 24. In CheckMate-649, which is a study of chemotherapy plus or minus nivolumab in patients with advanced gastric adenocarcinoma, there was again a very small number of patients, and patients that were MSI-high or deficient MMR did experience substantial benefits with the addition of immunotherapy, with hazard ratios in the order of about 0.38. In KEYNOTE-062, again, it was a very small number of patients, again about 6% or so, and similar to CheckMate-649, a substantial benefit was noted in combination with chemotherapy, but also there were benefits noted with pembrolizumab alone. The RATIONALE-305 again was a study of tislelizumab in combination with chemotherapy and similarly showed benefits to the combination of chemotherapy plus immunotherapy in this patient population. I think that we are all aware of the dramatic benefits of immunotherapy in this particular subset of patients, deficient MMR MSI-high, and also we have seen in CheckMate-649 they did have a subset of patients that received nivolumab and ipilimumab. And in this patient population, they noted unstratified hazard ratio of 0.28. So I think that the overall consensus is that immunotherapy is a very important treatment modality in patients with deficient MMR MSI-high disease, given that a lot of the trials in gastroesophageal adenocarcinoma have utilized chemotherapy-based options, that is certainly a recommendation of the panel to use chemotherapy in combination with immunotherapy. However, on a case-by-case basis, the panel recommended immunotherapy alone as well, and given the high response rates noted in trials across different diseases as well as noted in this disease as well. Brittany Harvey: Certainly. And I appreciate you both for reviewing these first-line recommendations. So moving to later lines of therapy, Dr. Rajdev, what recommendations did the expert panel make for second or third-line therapy for gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: So, I think that the RAINBOW trial that investigated the utility of the addition of ramucirumab as second-line therapy has been around since 2014, and those results have led to the addition of ramucirumab to taxane-based therapy in the second-line setting. Based on the utilization of oxaliplatin and platinum-based therapy in the front-line setting, there may be patients that have an underlying neuropathy, and so we wanted to really include treatment options for this patient population so that an agent that is less neurotoxic could also be recommended in combination with ramucirumab. The RAMIRIS trial is one such trial where ramucirumab was combined with FOLFIRI, and it demonstrated benefit in combination with ramucirumab. So we have listed that as a potential treatment option for patients in the second-line setting who may have an underlying neuropathy or even for whatever reason that based on the toxicity profile, that needs to be the preferred option by a physician, that recommendation is new from the older guidelines that we have. With regard to the utility of PD-1 inhibitors, there really has been no benefit noted in the second-line setting with regard to overall survival or progression-free survival, so no recommendation is made for that option. I think an important study that has been recently presented is the DESTINY-Gastric04 trial, which really has been practice-changing and has led to the recommendation for trastuzumab deruxtecan in patients that have HER2-positive metastatic gastric or GE junction adenocarcinoma. Now, this is a phase III trial in patients who retained HER2-positive disease after progressing on front-line trastuzumab-based treatments, and the comparator for this trial was trastuzumab deruxtecan versus ramucirumab plus paclitaxel. There was significant improvement and progression-free survival in patients that received trastuzumab deruxtecan. The patients that were excluded from the trial are patients that have pulmonary problems, interstitial lung disease; that is one of the toxicities of this particular agent, and close monitoring and prompt initiation of therapy such as glucocorticoid treatment in patients who develop this toxicity was also highlighted by the panel. So to summarize, the new guidelines highlight the possibility of FOLFIRI plus ramucirumab as a second-line option and then trastuzumab deruxtecan as a later-line option in patients that still retain HER2 expression. And that is very important because the trial did retest patients whether they expressed HER2. As we know, in a substantial number of patients, there is downregulation of HER2, and there is emerging data that the benefit for subsequent HER2-directed therapies is best noted in patients that still retain HER2 expression. Brittany Harvey: Great. So as our listeners have heard, there are many recommendations and new treatment options for advanced gastroesophageal cancer. Dr. Shah, earlier you highlighted the importance of biomarker testing, but I would like to hear in your view, what is the importance of this guideline and how will it impact both clinicians and patients with gastroesophageal carcinoma? Dr. Manish Shah: So as we have discussed throughout this podcast, the treatment for gastroesophageal cancer, both adenocarcinoma and squamous cell cancer, is increasingly complex, increasingly biomarker-driven. And I think the value of the guideline is to place all of that into context. So it provides the data for why certain biomarkers are important, what therapies should be indicated. Not only that, but if you are able to review the guideline, it provides the details of each of these studies and summarizes them in a meta-analysis fashion to sort of give you the context, because sometimes the individual studies can be maybe a little bit discordant or confusing and the guideline attempts to harmonize all that. And then also, I think the tables are very, very interesting because they give you actual numbers in terms of how many patients over a thousand would this benefit or how many patients over a thousand would this cause harm in terms of nausea, vomiting, or other things like that. So it gives you context for helping clinicians and patients weigh the potential benefits of the novel treatment strategies against the potential adverse events. And then finally, the guideline does also provide an algorithm that you are able to follow based on the biomarkers, and those are in figures 4 and 5. So I think overall, it is a very comprehensive guideline. It intends to make more manageable a very complex subject, and you know, I really encourage our listeners to review it after listening to the podcast. Dr. Lakshmi Rajdev: If I can add to that, I think that what is also really good about the guidelines is there are quick summaries. So if someone is busy in the clinic, of course, there is the opportunity to review the data supporting the guidelines in great depth in the manuscript, but what is also really good is that there are good summaries. In the event that you are very busy, you can easily identify what the recommendations should be for that particular patient based on these summaries. Brittany Harvey: Absolutely. Listeners are encouraged to review the full guideline, including those tables and figures that may be more helpful when they are looking for something quick to look at in the clinic as well. So, as you both mentioned, there have been a number of recent practice-changing trials in this area. So I imagine there is still a lot of ongoing research as well. So Dr. Shah, what are the outstanding questions regarding treatment options for patients with locally advanced unresectable, advanced, or metastatic gastroesophageal carcinoma? Dr. Manish Shah: I think we touched upon it a little bit. The guidelines are based on the data available, and they are primarily examining one novel therapy with chemotherapy in a specific biomarker population. But as you know, the biomarkers are not either/or; you are not either CLDN18.2 positive or PD-L1 positive. A portion of patients could have dual biomarkers, and you know, I think that we are generating data on how to manage those patients. At the recent GI Symposium in January this year, the ILUSTRO trial was presented by Dr. Shitara, which looked at combining zolbetuximab and chemotherapy with immunotherapy for dual-positive biomarkers, and that is leading to a phase III study that has begun to enroll. So unanswered questions are: how do we manage dual-positive biomarkers? The other thing that was mentioned is that the current data for mismatch repair deficiency involve chemotherapy plus immunotherapy. Only squamous cell cancer is there a study with a positive non-chemotherapy kind of backbone, that is CheckMate-648 that Dr. Rajdev mentioned. As we move forward, it will be good to get data on non-chemotherapy options in certain biomarker-positive populations. And then finally, another update, which is likely to be practice-changing, is the HERIZON-GEA-01 study that looked at zanidatamab, which is another biparatopic antibody that targets HER2, and that is likely to change practice. And as that data gets published, we may look to even do a rapid update for the current immunotherapy and targeted therapy guideline that is just being published. Dr. Lakshmi Rajdev: So, if I can add to that, there are numerous ADCs that look very interesting. There are bispecific antibodies; in fact, the zanidatamab is a bispecific antibody showing improved activity in patients with HER2-positive disease. So I think there are studies from Asia looking at CLDN CAR T-based therapies. So, I think that there are a lot of novel agents and a lot of excitement in the field. We know that the bemarituzumab study, unfortunately, the FGFR2 inhibitor failed to demonstrate any benefit, but I think that there are other agents that are being explored, so there are newer targets, newer agents, ADCs, bispecifics that could potentially change the field in the future. Brittany Harvey: Yes, we will look forward to the data to address these unanswered questions and new agents and inform future guideline updates. So, I would like to thank you both for all of your work to review the evidence here and update this important guideline, and for your time today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Pastor Tonya Marks helps our new host, Mark Bocci, warm up to the mic as he shares some of his ideas for Spotlight on Grace!

Hosts Mikah and Dan are revealing the off-the-radar apps they actually use and the creative ways they make Apple devices work smarter every day. Find out which overlooked tools help them (and maybe you) solve real-life digital annoyances. • Spotlight on Ivory by Tapbots as a top Mastodon client • NeatPass: Creating Apple Wallet passes from PDFs on-device • Screens app enables remote access and control across devices • Dice by PCalc delivers customizable, fun dice-rolling features • Television Time helps users track shows, episodes, and release dates • News: Apple's rumored special event and speculation on possible product launches • Feedback: Apple Creator Studio subscription benefits • App Cap segment: Belkin AirPods Cleaning Kit for device maintenance, and the Zephy app for identifying overhead airplanes in real time Hosts: Mikah Sargent and Dan Moren Contact iOS Today at iOSToday@twit.tv. Download or subscribe to iOS Today at https://twit.tv/shows/ios-today Join Club TWiT for Ad-Free Podcasts! Support what you love and get ad-free audio and video feeds, a members-only Discord, and exclusive content. Join today: https://twit.tv/clubtwit Club TWiT members can discuss this episode and leave feedback in the Club TWiT Discord.

John Meehan returns from episode 30. John Meehan is an instructional coach, professional development specialist, and English teacher from just outside Washington, D.C. He is the author of EDrenaline Rush (2019) and co-author of Fully Engaged (2021) and Playing With Purpose (2026). A nationally recognized speaker on student engagement and gamified instruction, John was named an ASCD Emerging Leader, served on the Bill & Melinda Gates Foundation Teacher Advisory Council, and currently sits on the Pulitzer Center's 2025 Information & AI Teacher Advisory Council. His book EDrenaline Rush was ranked among Book Authority's “Top 10 Teaching Books of All Time.” Alongside Michael Matera in 2021, John co-founded EMC² Learning, a global platform providing hundreds of gamified classroom resources to educators worldwide. EMC² Learning was named the 2023 FETC Pitchfest winner for Best Online Classes and honored in HundrED's 2024 Spotlight on Gamified Curricula. Outside the classroom, he's a CrossFitter and proud new dad. You can connect with John at connect@EMC2Learning.com and www.emc2learning.com

Hometown Radio 02/25/26 3p: Spotlight on New Life K9's

Roger Basick and Marina Santee tell about how a small Texas town became very popular because a young couple had the courage to chase after their dreams.https://spotlightenglish.com/uncategorized/chasing-dreams-all-the-way-to-waco/Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

Woman's Hour in collaboration with our SEND in the Spotlight podcast brings you a special programme on the impact of the government's SEND reforms in England.Whether you're a parent, a young person, a teacher or someone who works in the wider system we find out what the changes mean for you - and help you decode the new language - whether it's IB, ISP, Targeted, Targeted Plus, or SPP. Nuala McGovern speaks to parents, teachers, charities, the School Standards Minister and the Children's Commissioner for England. We also hear from SEND in the Spotlight podcast regulars - actors Anna Maxwell Martin and Kellie Bright.Search for the SEND in the Spotlight podcast on BBC Sounds.Contributors: Georgia Gould MP, Schools Standards Minister Marsha Martin, founder of Black SEN Mamas Katie Ghose, CEO of Kids charity and Disabled Children's Partnership Margaret Mulholland, Association of School and College Leaders Kate McGough, BBC Education reporter Eleanor Wright, solicitor at SOS!SEN Ramandeep Kaur, SEND parent Carrie Grant, SEND parent and broadcaster Katie Nellist, SEND ambassador Louise Gittins, chair of the Local Government Association Dame Rachel de Souza, Children's Commissioner for EnglandPresenter: Nuala McGovern Producer: Sarah Crawley, with Carolyn Atkinson Digital producer: Olivia Bolton Editor: Karen Dalziel

This week's episode features Phillip Mackey, a renowned metallurgist and member of the Canadian Mining Hall of Fame, in conversation with host Adrian Pocobelli on the West's efforts to build out metals processing capacity. Mackey explains how price floors, combined with new technologies and sustained commitment, can help Canada, the United States, and Europe achieve greater resilience in their supply chains. He also discusses key challenges, including energy constraints, tariffs, and China's dominance in much of the global metals processing sector. All this and more with host Adrian Pocobelli. This week's Spotlight features James Atkinson, CEO and Director of Antimony Resources, who discusses the company's Bald Hill antimony project in New Brunswick, Canada. To learn more, visit: https://antimonyresources.ca/ “Rattlesnake Railroad”, “Big Western Sky”, “Western Adventure” and “Battle on the Western Frontier” by Brett Van Donsel (⁠www.incompetech.com⁠). Licensed under Creative Commons: By Attribution 4.0 License ⁠creativecommons.org/licenses/by/4.0⁠ Apple Podcasts:⁠ https://podcasts.apple.com/ca/podcast/the-northern-miner-podcast/id1099281201⁠ Spotify:⁠ https://open.spotify.com/show/78lyjMTRlRwZxQwz2fwQ4K⁠ YouTube:⁠ https://www.youtube.com/@NorthernMiner⁠ Soundcloud:⁠ https://soundcloud.com/northern-miner

Send a textI stumbled upon Patrick Gabridge on the World Wide Web, and he was kind enough to come on to the Playwright's Spotlight after reaching out to him. If there was a playwright who has been in the spotlight who might have a pathway to success, it would be Patrick Gabridge. With a non-traditional approach to writing, Patrick focuses on site-specific plays that are staged in non-traditional stages. Before we delve into this, we speak about marketing and his networking group - Playwright Submission Binge - and how the market has dwindled and changed over the years and how it has affected non-equity theatre. We discuss his development of Plays in Places and its historical accuracy and use of creative license, how it's opened doors to success, the Secret Sauce, and pitching to non-traditional venues. We also breakdown approaching Youth Plays as an older playwright, writing competition plays, what constitutes high drama and whether or not there is a formula. We wrap things up with achieving exposition in a 10-minute play, experiencing poor productions of one's work, advice for finding/developing a writers group, and networking with playwrights. This is a fascinating conversation that should present any playwright with phenomenal opportunities. I'd love to how things transpire if anyone listening takes this path. Enjoy!Patrick Gabridge is a playwright whose work includes Blood on the Snow, Chore Monkeys, Lab Rats, Distant Neighbors, Fire on Earth, Flight, Constant State of Panic, Pieces of Whitey, Blinders, and Reading the Mind of God, which have been staged in theaters across the country. His plays can found in  Playscripts, Brooklyn Publishers, Heuer, Smith & Kraus and various“Best of” anthologies.He assisted is creating Boston's Rhombus Playwrights writers' group, the Chameleon Stage theatre company in Denver, the Bare Bones Theatre company in New York, the publication Market InSight… for Playwrights, and the on-line Playwrights' Submission Binge. He's also a member of the Dramatists Guild,  StageSource, and a board member of the Theatre Community Benevolent Fund.  In 2013, he co-founded the New England New Play Alliance and still serves as its coordinator.To view the video format of this episode, visit the link below - https://youtu.be/wkpI3jR_Or0Links to sites and resources mentioned in this episode -Playwright Marketing Binge - https://groups.io/g/playwrightbingeSeven Devils New Play Foundry - https://www.sevendevils.orgMid America Theatre Conference - https://matc.usThe O'Neill - https://www.theoneill.orgPlays in Place - http://playsinplace.comBrooklyn Publishers - https://www.brookpub.comHeuer Publishing - https://www.hitplays.comSocials for Patrick Gabridge and Plays in Place - FB - https://www.facebook.com/patrickgabridgeIG/Threads - @patrickgabridge YouTube -  ⁨@pgabridge⁩  FB - https://www.facebook.com/profile.php?id=61558727695681IG/Threads - @plays_in_placeWebsites and socials for James Elden, Punk Monkey Productions and Playwright's SpotlightPunk Monkey Productions - www.punkmonkeyproductions.comPLAY Noir -www.playnoir.comPLAY Noir Anthology –www.punkmonkeyproductions.com/contact.htmlJames Elden -Twitter - @jameseldensauerIG - @alakardrakeFB - fb.com/jameseldensauerPunk Monkey Productions and PLAY Noir - Twitter - @punkmonkeyprods                  - @playnoirla IG - @punkmonkeyprods       - @playnoir_la FB - fb.com/playnoir        - fb.com/punkmonkeyproductionsPlaywright's SpoSupport the show

Jerid is out this week so I have the one and only Brent Smith from Bald Man Knife and Tool join me. There will be no golf talk in this episode, you're welcome!Your hosts:Denis Tyrell of Tyrell Knifeworks:IG: @tyrellknifeworksYouTube: https://www.youtube.com/c/TyrellKnifeworksWebsite: https://www.tyrellknifeworks.comFacebook: https://www.facebook.com/people/Tyrell-Knifeworks/61558767232017/Brent Smith of Bald Man Knife and ToolIG: @baldmanktWebsite: https://www.baldmanknifeandtool.com/Jerid Sandoval of Echo Blades:IG: @echo_bladesFacebook: https://www.facebook.com/people/Echo-Blades/100085394408004/Maker's Spotlight: https://www.instagram.com/mozolicknives/ https://www.instagram.com/oegedcOur sponsors:Two Basterds Tx Smithy & Supplies: @twobasterdshammersMaritime Knife Supply: http://maritimeknifesupply.comPelican Paste: https://pelicanpaste.com (Use TTT10 for 10% off!)Baker Forge and Tool: https://www.bakerforge.com (Use TTT10 for 10% off!)Grip Tech Composites: https://rocksolidscales.com/ (Use TTT10 for 10% off!)Evenheat Kilns: Https://Evenheatkilns.com/Ameribrade: https://www.ameribrade.com/The Drop Point: https://thedroppoint.com/Podcasts we think you'll like: Hustle and Grind Work For It Fire and Steel KnifeTalk FullBlast ForgeSideChat Artisans of Steel Knife Perspective

Roger Basick and Marina Santee tell about how a small Texas town became very popular because a young couple had the courage to chase after their dreams.https://spotlightenglish.com/uncategorized/chasing-dreams-all-the-way-to-waco/Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

It's a new "season" on the Spotlight on Grace Podcast, and we have more stories to share and ways to thank God for his grace in our lives and the life of Columbia Grace Church of the Nazarene! Welcome Mark Bocci to his first episode as host! Mark has lots of great ideas and will be welcoming in new guests! We're excited that you're here for the journey!

The Missouri Soybean Association has secured state tax relief for federal disaster assistance payments. In this Spotlight on Soybeans, Ben Travlos, the director of policy with the Missouri Soybean Association, has more details.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Producer Nick Earnshaw and my intern Erin Ewing join me in the studio. We pay tribute to Legendary former Captain of the Avalon Beach Patrol Murray Wolf who just passed away. We'll hear from a Lt of the Avalon BP 3X South Jersey Champion Craig Whitehead. Hour II we'll check in with Paul Lundholm who is in Clearwater with his Phillies spring training report and our "High School Athletes in the Spotlight" with Fran Mclaughlin.

Jason Nitz, Dean of School Culture at Cristo Rey San Diego High School, joins student interns to share how their innovative work-study model creates a diverse talent pipeline for local businesses. Discover how executives can partner with Cristo Rey to advance corporate social responsibility, workforce development, and community impact through real-world student jobs. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Anthony Elliot, police officer and founder of Bulletproof Tony, and Laura Elliot, co-founder and keynote speaker, share a powerful roadmap for resilience, recovery, and building a “bulletproof” mindset that prepares leaders for unexpected crisis and trauma. They discuss life diversification, failure as a strategic advantage, and how strong family, culture, and community support can transform the way executives lead teams through adversity. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Tom Felkner, Executive Director of the San Diego Museum Council, Brian Drechsler, Executive Director of the Navy SEAL Museum, and Alethea Arguilez, Executive Director of First 5 San Diego, discuss Museum Month, leadership, service, and expanding access for 70+ museums across the region. This episode explores nonprofit leadership, early childhood education, veterans' impact, public-private partnerships, and how executives can strengthen community engagement and workforce development. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

David King, Executive Director of the San Diego–Imperial Valley High Intensity Drug Trafficking Area (HAIDTA), discusses regional drug trafficking, the fentanyl crisis, and overdose prevention with Drew Schlossberg and Kristen Fogle. San Diego executives will hear actionable strategies on public safety, community partnerships, law-enforcement coordination, drug demand reduction, school prevention, and federal-local funding to protect employees, families, and neighborhoods. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Jim Davis, Executive Director of North County Philanthropy Council, and Neville Billimoria, Board President, discuss nonprofit leadership, collaboration, volunteerism, and the Impact Leadership Accelerator. They explore San Diego Gives, the Day of Giving, board governance, community engagement, and how executives can strengthen organizational impact through partnerships and purpose-driven strategy. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Hometown Radio 02/20/26 3p: Pet of the Week & a chance to win that gift card from Linn's and a Spotlight on the California Rare Fruit Growers Association

Riley Tejcek, Captain and Officer of Recruiting and Sports at MCRD, discusses leadership development, elite team culture, and transitioning from Division I athlete to Marine officer and Team USA bobsled pilot. She shares insights on resilience, performance under pressure, and building high-performance teams in uncertain environments. A powerful conversation for executives focused on talent, grit, and mission-driven leadership. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Michael Hall, Captain and Assistant Chief of Staff for Religious Ministries at MCRD, and Natalie Bakan, Commander and Officer in Charge of Dental Detachment, discuss spiritual fitness, “a ministry of presence,” and building the “total Marine.” They share how world-class dental readiness and inner strength from higher purpose drive resilience, leadership, and mission readiness—lessons executives can apply to culture and performance. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Natalie Lamb, Lieutenant Colonel and Commanding Officer of First Recruit Training Battalion at MCRD, discusses servant leadership, recruiting, and “making Marines” through honor, courage, and commitment. She shares insights on building resilient teams, developing emerging leaders, and transforming young men and women into purpose-driven citizens. A powerful conversation for executives focused on leadership, culture, and mission impact. Listen Where You Live!About Spotlight and Cloudcast Media  "Spotlight On The Community" is the longest running community podcast in the country, continuously hosted by Drew Schlosberg for 20 years.  "Spotlight" is part of Cloudcast Media's line-up of powerful local podcasts, telling the stories, highlighting the people, and celebrating the gravitational power of local.   For more information on Cloudcast and its shows and cities served, please visit www.cloudcastmedia.us. Cloudcast Media | the national leader in local podcasting.   About Mission Fed Credit Union  A community champion for over 60 years, Mission Fed Credit Union with over $6 billion in member assets, is the Sponsor of Spotlight On The Community, helping to curate connectivity, collaboration, and catalytic conversations.  For more information on the many services for San Diego residents, be sure to visit them at https://www.missionfed.com/

Hometown Radio 02/19/26 3:30p: Spotlight on SOFTEC

Send a textThis week, the In the Crease boys bring you the usual line-up, with the Top 10 Countdown, Week in Review, Games to Watch, and the Game of the Week.  For our Player's Spotlight, we sit down with player who started his college career with a bang - Lasse Volquardsen of SNHU. Make sure to check it out!You can check out SNHU at:SNHU: Twitter - @penmenlacrosse             Instagram - @snhu_lacrosseIf you like what we are doing, subscribe on your favorite podcast platform and help us spread the word of the great things happening in D2 Men's Lacrosse! Go to our website: www.inthecreaselacrossepod.com Follow us at: Instagram: @in_the_crease_d2_lax Facebook: In the Crease with Danny and Kevin Twitter: @D2_Lax_podcast

Alice Irizarry and Patrick Woodward talk about a mother found the strength to forgive and do even greater things for many more girls.https://spotlightenglish.com/uncategorized/angelina-atyam-the-forgiveness-of-a-mother/Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

Hometown Radio 02/17/26 3:30p: Spotlight on the SLO Childrens Museum

Today we call a guy who recently asked his lady to define their relationship and before he gets the green light from her, we’re turning the SPOTLIGHT on him interrogation style!See omnystudio.com/listener for privacy information.

Today we call a guy who recently asked his lady to define their relationship and before he gets the green light from her, we’re turning the SPOTLIGHT on him interrogation style!See omnystudio.com/listener for privacy information.

In December 2024, Dominque Pelicot and 46 other men were found guilty of the aggravated rape of his wife Gisèle. Another two were found guilty of attempted rape and a further two were found guilty of sexual assault. Dominque had drugged Gisèle with medication without her knowledge, raped her and invited other men to rape her, filming as they did so. At least another 20 men who took part in these rapes could not be identified. Waving her right to anonymity, Gisèle Pelicot declared that shame has to change sides. Despite her becoming a household name, not only in her native France but around the world, very little was known about Gisèle herself.Today sees the publication of her much-anticipated memoir, A Hymn to Life. Nuala McGovern is joined by writer and journalist Judith Perrignon, who co-wrote the memoir with Gisèle, and Professor Manon Garcia, who watched the trial in Avignon and analysed its resonance in her book Living with Men, Reflections on the Pelicot Trial. The award-winning internationally renowned Welsh harpist and composer Catrin Finch first came to prominence in her early 20s as the official Royal Harpist to King Charles, the-then Prince of Wales. She achieved chart success with her No. 1 recording of Bach's Goldberg Variations and has performed with many of the world's leading orchestras. Catrin, who began playing the harp at just six years old, has a new album, Notes to Self, a series of reflective and deeply personal new tracks she has composed for Katy, her 13-year-old-self. She tells Nuala about her first album of solo compositions in a decade.One of the children talking about their everyday achievements in our new podcast, SEND in the Spotlight, which features young people with special educational needs, is Henry. He's autistic, and school is not always easy. Things got even tougher when his grandma died. That's when Henry decided to raise money for the hospice which looked after her. We hear his story in his own words.With the Winter Olympics in full swing in Italy, how are sports like ice hockey faring here in the UK? And what are women doing on the ice rink? Joining Nuala are Ellie Wakeling and Abbie Sylvester, who both play alongside male players with the Romford Buccaneers.Presenter: Nuala McGovern Producer: Andrea Kidd

Electric motors without rare earths, a hardware-first climate tech startup, and a mission to replace 1 billion gas engines in a decade. In this SPOTLIGHT episode, Abhay speaks with Ankit Somani, CEO and cofounder of Conifer, about redesigning electric motors and powertrains with simple, widely available materials so electrification can actually scale.They break down what rare earth materials really are, why they're so toxic and geopolitically fragile, and how that impacts everything from EVs and data centers to humanoid robots and everyday devices. Ankit explains why Conifer is betting on hardware in a software-obsessed world, what it takes to raise capital for hard tech, and how to tell a big, unconventional story that still feels real to customers and investors.The conversation also dives into affordability, why consumers choose “cool and fun” products long before they care about emissions, and how things like e‑bikes and cleaner small machines (like leaf blowers) can change daily life and local air quality. Ankit reflects on what he had to unlearn from big companies like Google, why patience and brutal feedback define startup culture, and how his Indian American journey, parenting, and the Bhagavad Gita shape his views on action, success, and legacy.00:00 – Introduction and why reimagining how we do things matters01:47 – Conifer's mission to replace 1 billion gas engines03:39 – Engines, electric motors, and rare earth materials 101 (toxicity, supply chains, and climate)12:32 – Building a hardware-first climate tech startup in a software-obsessed world15:36 – Raising capital for hard tech and telling an unconventional, big vision story18:13 – Sposor Break: Travelopod18:48 – Selling electrification: cool, fun, and affordable vs. abstract climate consciousness25:08 – From big tech to startups: patience, humility, and real-world feedback loops33:08 – Indian American founder, education, parenting, and the Bhagavad Gita on action and legacy39:09 – What Ankit wants Conifer to stand for: trust, honesty, and long-term impactShout out to ASAN (American South Asian Network) for everything they are doing, to Neesha for turning 30, to Farhan Akhtar for the upcoming sitar lessons, and to Akshay Bhatia for the effort and almost bringing it home at Pebble Beach!TRUST ME I KNOW WHAT I'M DOING is brought to you by TRAVELOPOD, with personalized travel support to help you explore the wonders of the world.  Start your next journey at vacation.travelopod.com

Ari Meirov's first Spotlight guest following the Super Bowl is none other than New York Giants tackle (and soon to be free agent) Jermaine Eluemunor! Jermaine explains his journey from teenager in London learning about football, to moving to the states, to college, and then to the NFL. He highlights the ups and downs leading to his career year in 2025. Hit subscribe and grab your popcorn! Visit Root.com and learn how you can save for good driving today! -------------------- Visit FanDuel.com and use profit boost on an NBA future for chance to go to the NBA Finals. Visit FanDuel.com to learn more! -------------------- NFL Spotlight is dedicated to shining a light on those in the NFL that deserve a spotlight with top-notch insight and research from Ari Meirov. Follow Ari on X: https://x.com/MySportsUpdate Follow Ben on X: https://x.com/BenAllenSports Follow The 33rd Team on X: https://x.com/The33rdTeamFB Learn more about your ad choices. Visit megaphone.fm/adchoices

Curious how in-person strategy sessions can transform a brand? Discover firsthand insights from 5 client on-sites Michelle went on in January, the latest trends in audience engagement, and actionable takeaways for elevating both your brand presence and community connection. Get a look at the real impact of showing up, asking the right questions, and driving intentional growth. ------------------------ In today's episode, we cover the following: Content creation at in-person events Dental Hygiene Nation & Dental Hygiene Seminars Event engagement and content strategy Spotlight on Bloom RDH The questions to ask your customers in person? Building partnerships through branding Visits with Falk Ruvin Gallagher Aesthetic authority and thought leadership Community hosting as a trend Onsite with Galavant Society The power of in-person collaboration How to work with us in 2026 ---------------------- RESOURCES: Episode 251: How to Work with MKW Creative Co. in 2026 Episode 233: Why In Person Client Meetings Matter Episode 230: Client Case Study: Galavant Society Episode 220: Rising Costs and Brand Resilience with Dental Hygiene Nation Episode 215: Client Case Study: FRG Real Estate Part 2 Episode 193: Client Case Study: Bloom RDH Episode 174: Client Case Study: FRG Real Estate Episode 131: Building a Merch Brand with Caitlyn Rastetter of Dental Hygiene Nation ----------------------- WORK WITH MKW CREATIVE CO.   Connect on social with Michelle at: Kiss My Aesthetic Facebook Group Instagram Tik Tok -----------------------   -- COFFEE -- Did you know that the fuel of the POD and the KMA Team runs on coffee? ;) If you love the content shared in the KMA podcast, you're welcome to invite us to a cup of coffee any time - Buy Me a Coffee! -- ZENCASTR -- This episode is brought to you by Zencastr. Create high-quality video and audio content. Get your first two weeks free at https://zencastr.com/?via=kma . -- AUDIBLE -- This episode of the Kiss My Aesthetic Podcast is brought to you by Audible. Get your first month free at www.audible.com/kma.   This episode was edited by Berta Wired Theme music by: Eliza Rosevera and Nathan Menard

In a special Spotlight review Gareth joins Benno to talk the AEW Grand Slam card from Sydney, the wider AEW title picture, use of Brody King, Andrade, Kyle Fletcher and more.They also talk AEW and WBD, WWE's rough WrestleMania season, the possible end of AJ Styles to AEW speculation, Chris Jericho, and more.Enjoy!Bennohttps://www.youtube.com/live/iZyJckOauyI?si=7MSGdB5PfzvAWNfGSHOWNOTES00:00 Intro, Plugs13:51 AEW catchup, World Title scene, Grand Slam Review1:07:08 News, AEW and WBD, TNA Sacrifice, WrestleMania, AJ StylesGRAPPL Spotlight is produced with support from our Patrons and YouTube members, with special thanks to Patreon Kings and Queen Of The Mountain - Conor O'Loughlin, Eddie Sideburns, Chris Platt, Carl Gac, Sophia Hitchcock, Simon Mulvaney & Marty Ellis!You can find all of our live shows on YouTube by becoming a Member at ⁠http://www.Youtube.com/@GRAPPL,⁠ or join us on Patreon for both live video and audio replays at ⁠http://www.patreon.com/GRAPPL!⁠You can also join us on the GRAPPL Discord for free athttps://discord.gg/KqeVAcwctS⁠ Hosted on Acast. See acast.com/privacy for more information.

This week's episode features Alon Olsha, Senior Analyst for Metals & Mining at Bloomberg Intelligence, in conversation with host Adrian Pocobelli about the recent failed merger discussions between Rio Tinto and Glencore. Olsha explains how the sheer complexity of combining two global mining giants proved a major obstacle, alongside issues such as valuation gaps and management structure. He also traces the history of the two companies and their long-standing merger speculation, examines their respective portfolios, and analyzes how a combined entity might have complemented each business. All this and more with host Adrian Pocobelli. This week's Spotlight features Ricky Chan and Gary Baschuk, Co-Heads of Mining at PearTree Canada, discussing the state of mining finance, the role of flow-through shares, and what they're expecting at this year's PDAC conference. To learn more, visit: https://peartreecanada.com/ “Rattlesnake Railroad”, “Big Western Sky”, “Western Adventure” and “Battle on the Western Frontier” by Brett Van Donsel (⁠www.incompetech.com⁠). Licensed under Creative Commons: By Attribution 4.0 License ⁠creativecommons.org/licenses/by/4.0⁠ Apple Podcasts:⁠ https://podcasts.apple.com/ca/podcast/the-northern-miner-podcast/id1099281201⁠ Spotify:⁠ https://open.spotify.com/show/78lyjMTRlRwZxQwz2fwQ4K⁠ YouTube:⁠ https://www.youtube.com/@NorthernMiner⁠ Soundcloud:⁠ https://soundcloud.com/northern-miner

As supply chains expand across global networks, the next generation of leaders is being trained to think beyond trucks and warehouses, toward the broader constraints shaping business today. Dr. Morgan Swink, West Chair, Professor of SCM and Executive Director of the Center for Supply Chain Innovation at Texas Christian University's Neeley School of Business, joins Supply Chain Now alongside three standout seniors, Ava Scotchie, Joshua Ahn, and Cort Comer, to share what they're seeing in real time as they prepare to enter the industry.In this Now Generation conversation, Scott Luton and Dr. Swink explore what makes TCU's supply chain program so distinctive, from high-touch faculty mentorship and curriculum that mirrors real workplace ambiguity, to site visits, case competitions, and capstone projects designed to deliver real value to companies. The students share how these experiences have shaped their confidence, career direction, and readiness to lead.They also dig into the trends these emerging professionals are watching most closely: reverse logistics and the rising cost of returns, sustainability and ethical visibility across multi-tier suppliers, and the growing energy and infrastructure demands driven by AI and data center expansion. The episode highlights how supply chain thinking is evolving, and why the leaders who can connect operations, ethics, and resource constraints will be the ones who shape what comes next.Jump into the conversation:00:00) Intro(01:43) Spotlight on TCU's supply chain program(02:14) Meet the student leaders of supply chain(03:32) Ava discusses her passion for supply chain(04:05) Joshua shares his global supply chain journey(04:36) Cort focuses on energy and supply chain(12:10) Dr. Swink's vision for the program(14:26) Students discuss top supply chain trends(23:52) Career goals and making a lasting impact(26:33) Joshua on driving supply chain sustainability(28:03) Career advice for aspiring supply chain leaders(29:59) Cort on energy's role in supply chain(38:21) Ava reflects on TCU's hands-on learning(47:28) Building meaningful supply chain connectionsAdditional Links & Resources:Connect with Dr. Morgan Swink: https://www.linkedin.com/in/morgan-swink-8331ab11/Connect with Ava Scotchie: https://www.linkedin.com/in/ava-scotchie,Connect with Joshua Ahn: https://www.linkedin.com/in/joshuajahn/Connect with Colt Comer: https://www.linkedin.com/in/cort-comerLearn more about TCU's Neeley School of Business:

Alice Irizarry and Patrick Woodward talk about a mother found the strength to forgive and do even greater things for many more girls.https://spotlightenglish.com/uncategorized/angelina-atyam-the-forgiveness-of-a-mother/Download our app for Android at http://bit.ly/spotlight-androidDownload our app for iOS at http://bit.ly/spotlight-appleFacebook: https://www.facebook.com/spotlightradioAre you learning English? Are you looking for a way to practice your English? Listen to Spotlight to learn about people and places all around the world. You can learn English words, and even practice English by writing a comment.Visit our website to follow along with the script: http://spotlightenglish.com

In this episode of Around the Bird Bath, hosts Dan and Rylan discuss the opening weekend for UTSA Baseball, highlighting the team's performance in their series against South Dakota State. They delve into the unfortunate injury of junior ace Rob Orloski, the pitching staff's performance, and the offensive explosion that saw the team score 43 runs over the weekend. The conversation also touches on the upcoming midweek game against Illinois Chicago and the potential challenges ahead as the team prepares for tougher competition. 00:00 Weekend Recap and Opening Series Highlights 06:19 Rob Orloski's Injury 15:05 Pitching Performance Overview 18:54 Debut of Freshman Pitchers 26:03 Offensive Explosion: Hitting Highlights 27:39 Aggressive Base Running and Player Development 29:01 Spotlight on Aidan Eshelman 32:44 Caden Miller's Leadership and Performance 35:43 Previewing the Upcoming Game Against UIC Video: https://www.youtube.com/watch?v=lMor6-ws_T8

Dive into the 2026 NFL Draft's edge rusher class as host Ryan Schlipp dissects the top prospects with in-depth analysis, stats, and compelling backstories. From breakout stars to injury comebacks, this episode uncovers what makes these players potential game-changers for teams like the Packers. Get ready for a deep dive into tools, traits, and tape that could shape the league's future pass rush. Spotlight on elite talents like Ruben Bain and David Bailey, including their dominant stats, pro comps to Micah Parsons and Von Miller, and how they stack up as top-five picks. Exploring under-the-radar risers such as Cashus Howell's "ghost move" and Zion Young's Senior Bowl dominance, plus concerns like arm length and injury histories. Breaking down versatile prospects like Keldrick Faulk and TJ Parker, with insights on their builds, breakout seasons, and family football legacies. Discussing high-risk, high-reward types like R. Mason Thomas and Akeem Mesidor, including off-field flags, age factors, and projection to NFL roles. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. Subscribe, rate, and review on your favorite platform to stay in the loop on all things Packers. Follow @Pack_Daddy on X for more insights and join the conversation! Tell me your thoughts on this one — I want to hear from you. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Support the Show & Explore My Projects Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Projects: https://nfldraftgrades.com/ My Board:  https://nfldraftgrades.com/board/83a18c42-7a0b-4590-8d1b-453e49840d02