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OKYO Pharma CEO Gary Jacob joined Steve Darling from Proactive to announce a strategic decision to accelerate the clinical development of urcosimod, its lead candidate for Neuropathic Corneal Pain. CEO Gary Jacob shared the update in an interview with Proactive, highlighting the company's decision to terminate its ongoing Phase 2 trial early in order to access and analyze masked trial data that could inform the next stage of clinical advancement. The Phase 2 trial, being conducted at Tufts Medical Center in Boston, MA, was initially designed as a single-site study to evaluate the safety and efficacy of urcosimod in patients suffering from NCP—a debilitating and poorly understood ocular condition. To date, 17 patients have successfully completed the trial. All of them were diagnosed with chronic, long-term NCP and had failed multiple prior therapies, positioning this cohort as a challenging yet highly relevant population for evaluating urcosimod's potential. According to Jacob, the trial has attracted significant attention from NCP sufferers, reinforcing the high unmet need in this patient population. NCP is characterized by severe ocular pain, light sensitivity, and discomfort that can radiate to the face or head. Its exact etiology remains uncertain but is believed to involve nerve damage and persistent inflammation of the cornea. Currently, no approved therapies exist specifically for NCP, and most patients rely on off-label or palliative treatments with limited success. OKYO's decision to close the trial early reflects a proactive strategic shift, allowing the company to refine its clinical development path and expedite next steps. The company is preparing to launch a multicenter trial, which will include multiple clinical sites and a broader patient population, enhancing the statistical robustness and generalizability of the data. As OKYO prepares for this next clinical phase, the company remains focused on its core mission of delivering innovative therapies for underserved ophthalmic conditions. The accelerated pathway for urcosimod underscores its potential to reshape the treatment landscape for neuropathic eye disorders. #proactiveinvestors #okyopharmalimited #nasdaq #okyo #Urcosimod #NeuropathicCornealPain #BiotechNews #ClinicalTrials #FDAapproval #Ophthalmology #DrugDevelopment #CompassionateUse #EyeHealth
Tom Clarke is joined by Gary Jacob and Martin Hardy to look at all the latest transfer news.Will Ollie Watkins be an Arsenal player in the next 48 hours? Newcastle have sold Miguel Almiron will they have to sell more players to meet PSR rules? Which other clubs are planning last minute deals; Tottenham, West Ham, Man Utd, Man City, Liverpool, Brighton. How are deals done; the inside track on continuing to pay wages even if you sell a player and why are deals always done so late in the window? Lastly, how do reporters deal with agents, club presidents and managers and the half-truths, spin and outright lies that do the rounds…? Hosted on Acast. See acast.com/privacy for more information.
Hugh Woozencroft is joined by Tom Clarke, Alyson Rudd, Gary Jacob and Michael Grant.The Nations League games continue and England once again failed to impress against Italy. Are the squad tired and is the manager in need of a rest too? (00:00)Gareth Southgate changed things around for the game against the European Champions - which players showed they deserve more of a chance in the starting line up? (09:45)Scotland have had a disastrous start to their Nations League campaign. Michael Grant joins us to discuss their current slump after watching them lose 3-0 in Dublin (23:16)Wales showed more promise, holding Belgium to a 1-1 draw in Cardiff. Gareth Bale edges closer to becoming a free agent, but is there any indication of where he'll end up? (32:52)Everton have signed a record shirt sponsorship deal with a betting company - but with these kinds of sponsorships looking like they'll be banned, was that a foolish decision on several levels? (43:42)Get more of The Times and The Sunday Times for less than £1 a day. Start your free trial: thetimes.co.uk/thegame See acast.com/privacy for privacy and opt-out information.
Hugh Woozencroft is joined by Tom Clarke, Michael Grant, Gary Jacob and Tomas Hill Lopez-Menchero.Scotland came up short against Ukraine, who go on to face Wales on Sunday for a place in the World Cup. Michael Grant joins us to discuss what went wrong and where Steve Clarke's side go from here (00:00Wales will have had a good look at Ukraine ahead of that game. Gary Jacob weights up what could be Gareth Bale's last match for his country, should they lose and miss out on the finals (18:21)Paul Pogba is leaving Manchester United. Not a huge surprise, but was his time at the club a success or was he not given what he needed to thrive? (28:32)Gareth Bale is also on the move with his deal at Real Madrid ending next month. Is the Welshman the best British export ever? Tomas Hill Lopez-Menchero joins us to weight it up (36:55)..and with Tom Clarke on holiday on Monday when we'll hold our end of year awards, we let him pick some of his winners a few days early (45:49)Get more of The Times and The Sunday Times for less than £1 a day. Start your free trial: thetimes.co.uk/thegame See acast.com/privacy for privacy and opt-out information.
For this special episode of Something Will Happen, Melissa is once again joined by producer Gary Jacob. Together they look back on the last 20 years of Abbey Road on the River. Gary tells us of the bands, the fans, and the music that has brought us all together.
On this week's episode of Something Will Happen, Melissa and AROTR producer Gary Jacob sit down and talk with our 2022 headliner: Tommy James of Tommy James and the Shondells. Tommy James has been making hit music over the span of a 5 decade long career. To say that he is a legend would be an understatement! He has 23 gold records, 9 platinum albums, and sold over 100 million records worldwide.
Melissa is joined by producer, Gary Jacob to discuss plans for the 2022 AROTR festival.
In honor of AROTR's 20th anniversary, our first episode of Something Will Happen goes over the history of our beloved Beatles festival, Abbey Road on the River! We spoke with the producer of the festival, Gary Jacob, and got some great insights on how it all started. Visit Abbey Road on the River for full show notes and more info!
Hugh Woozencroft is joined by Gregor Robertson, Matt Lawton and Henry Winter.England have recorded back-to-back wins in World Cup qualifiers. The last game saw Jesse Lingard and Trent Alexander-Arnold return - but what does the future hold for both? (00:00)The Times' Chief Football Writer, Henry Winter joins us with his thoughts on the England qualifier and whether Gareth Southgate has been grilled enough after the Euro 2020 final loss (16:18)We get the latest from the Wales camp with Gary Jacob, after Gareth Bale proved a few people wrong with a hat trick against Belarus. Scotland also did well, beating Moldova 1-0 (42:30)We unpack the madness after the game between Brazil and Argentina was abandoned after four players allegedly tricked their way into the country by saying they hadn't been the UK in the past fortnight. This lead to Government officials storming the pitch early in the game (50:18)The new WSL season got underway over the weekend and with increased media coverage this season, The Times' Molly Hudson joins us to discuss how this could be a pivotal year for the women's game in the UK (53:00)Get more of The Times and The Sunday Times for less than £1 a day. Start your free trial: thetimes.co.uk/thegame See acast.com/privacy for privacy and opt-out information.
Hugh Woozencroft is joined by Gregor Robertson, Ian Hawkey and Gary Jacob.Wales have given themselves every chance of qualifying for the knockout stages with an impressive 2-0 win over Turkey. Why were Turkey so lacklustre - especially with their president in the stadium? (00:00)Gary Jacob was with Hugh in Baku and added his thoughts on a Wales performance that saw Gareth Bale and Aaron Ramsey at their very best (04:54)Italy have won both of their opening games 3-0 and with the latest win over Switzerland, look like they could trouble most sides as the tournament go on (21:42)Denmark play their next game tomorrow but how will the events of their opener affect the squad mentally and do they have any chance in recovering from that trauma to turn things around? (26:25)Today's results:Finland 0-1 RussiaTurkey 0-2 WalesItaly 3-0 SwitzerlandGet more of The Times and The Sunday Times for less than £1 a day. Start your free trial: thetimes.co.uk/thegame See acast.com/privacy for privacy and opt-out information.
Hugh Woozencroft is joined by Tom Roddy and Jonathan Northcroft.England have named their 26 man squad and played their first of two warm up games - so how are they shaping up ahead of Euro 2020 and will they really need four right backs? (00:00)Wales had a tough night in Nice - playing most of their 3-0 friendly loss to France with 10-men after Neco Williams was dismissed. Despite that, Gary Jacob joins us to discuss the positives for Rob Page’s side (25:56)Scotland were denied a surprise victory in their warm up match against the Netherlands, despite having a number of key players missing. Could they be the surprise package in the tournament? Michael Grant joins us to discuss the positives for Steve Clarke’s side (36:47)Aside from the Euros, it’s already an interesting summer in the world of Premier League managers. Who will Everton and Spurs appoint and will it bring them the success they need after disappointing seasons? (40:59)Get your digital subscription to The Times and get a month free: thetimes.co.uk/thegame See acast.com/privacy for privacy and opt-out information.
In another Beatles News Briefs Extra show, Gary Jacob of Abbey Road tells us the latest plans for the show in the wake of the coronavirus. Visit his website at http://www.arotr.com.
A tough weekend for both halves of North London with incredible scenes at The Emirates as captain Xhaka goes to war with The Gunners faithful!Natalie Sawyer and Gregor Robertson are joined by Matt Dickinson and Gary Jacob for more on this, Sean Dyche's call for red cards for diving and whether Tottenham's problems really are all Dele Alli's fault.Plus we hear how Gregor got on when he went to visit Sol Campbell at Southend United. See acast.com/privacy for privacy and opt-out information.
Health, Pharma, Industry Icon Gary S. Jacob - Interview The Not Old Better Show - Business Buildout Welcome to The Not Old Better Show, I'm Paul Vogelzang, and this is episode #395. As part of our Business Buildout, CEO Interview Series, our guest today on The Not Old Better Show is Dr. Gary Jacob. Despite an incredibly busy, demanding schedule, Dr. Jacob agreed to join us and answer questions about himself, his background successes, and the success of the company Immuron, where Dr. Gary Jacob is CEO. Immuron, as you'll hear from Dr. Jacob, and have heard on previous programs, makes the successful Travelan product. In preparation for today's interview, I had a series of pre calls with Dr. Jacob, and I am hoping for as much energy, brainpower and pure business acumen as this man. Dr. Jacob will impress you as he has me with his expertise, experience, and a deep knowledge of science. Briefly, Dr. Gary Jacob is the Chief Executive Officer of Immuron and has 30+ years of extensive experience in the pharmaceutical and biotechnology industries covers multiple disciplines, including research and development, operations, business development, capital financing activities, and senior management expertise. I thoroughly enjoyed this conversation and I know you will. Finally, before we introduce Dr. Jacob, I will tell you all that we anticipate having Dr. Jacob back soon to give us more about himself and his background, so stay tuned. But, today, please join me in welcoming to The Not Old Better Show, via internet phone, Dr. Gary Jacob. My special thanks to Dr. Gary Jacob for joining me today, and please check out The Not Old Better Show web site for more details in Dr. Jacob's bio. And, of course, my thanks always to the wonderful Immuron and Travelan team for all they do to support the show. The Not Old Better Show. Talk About Better. Thanks, everybody. Check out Travelan: https://www.amazon.com/dp/B01JOE7RGM
After a weekend full of football Gregor Robertson is here to analyse all the ups, downs and that 'disruptive' VAR.Alongside Gregor we have The Times' very own Gary Jacob and Martin Hardy. Could this be the season that will cause major trouble for the usual top six?Our Scottish football correspondent Michael Grant also stops by to chat all things Rangers, Celtic and how much longer Steven Gerrard will be able to keep fans on side, following that 2-0 defeat! See acast.com/privacy for privacy and opt-out information.
Natalie Sawyer is joined by Alan Smith, Gary Jacob and Paul Hirst after a seismic Easter weekend.Manchester United are embarrassed and humiliated, losing 4-0 to Everton at Goodison Park. Ole Gunnar Solskjaer wasn’t sure if all of his players care enough. We discuss who he might be talking about and look ahead to the Manchester derby on Wednesday. Will United respond, damaging City’s title hopes, helping Liverpool in the process? The race for the top 4 seems to be a race nobody wants to win, as Arsenal and Tottenham also lose. The panel try to decide who will qualify for the Champions League and who needs it the most? Elsewhere, where will Wilfried Zaha be next season? And will Brighton have enough to survive? See acast.com/privacy for privacy and opt-out information.
After a full midweek fixture list, Gab Marcotti, Natalie Sawyer and Gary Jacob look ahead to a weekend packed full of derbies. Chelsea sweep aside Spurs despite the controversy surrounding the many statements of Kepa. Is Harry Kane’s frustration at Stamford Bridge, coupled with Mauricio Pochettino’s frustration at Turf Moor, indicative of a larger frustration? Arsenal are next in the North London derby. The Gunners are in form but is Unai Emery in emergency mode? Then follows the Merseyside derby on Sunday as we make the case for Alexander-Arnold and Robertson being the best pair of full-backs in the league. And how long do we give Marco Silva before we judge the job he’s doing at Everton? Brendan Rodgers leaves Celtic for Leicester but should he have been allowed to? Plus in a move we saw coming, Fulham part company with Claudio Ranieri, after he fails to make a good defence. Charlie Scott and Paddy von Behr provide advice ahead of the fantasy football weekend. For free Fantasy Premier League tips from The Sweeper, visit thetimes.co.uk/fantasyfootball See acast.com/privacy for privacy and opt-out information.
It’s Christmas Eve but Natalie Sawyer and Gab Marcotti are hard at work bringing you The Game podcast from The Times with Henry Winter and Gary Jacob.It’s time to critique an incredible Crystal Palace performance at the Etihad as they beat the champions Manchester City. It’s a result that sends Liverpool 4 points clear at the top of the table but Henry Winter is quick to highlight the humility of Jurgen Klopp’s squad. Including perhaps the most important player in the league, Virgil Van Dijk.Tottenham thrash Everton 6-2 but how big will the January transfer window be in terms of providing a clue as to Mauricio Pochettino’s future? And how big is the window for the top 4 hopes of Chelsea and Arsenal?Manchester United put 5 past Cardiff in Ole Gunnar Solskjaer’s first game in charge. Can United be accused of cheating Jose Mourinho or are they just a group of very good players? And has Solskjaer been given the remit to show off some of the lesser seen stars?Plus we look at Mike Dean’s flamboyant behaviour, Neil Warnock’s hair and Ralph Hasenhüttl in Rocky II. See acast.com/privacy for privacy and opt-out information.
Gab Marcotti and Natalie Sawyer are joined by Henry Winter and Gary Jacob ahead of a huge weekend of Premier League action.Tottenham have beaten Chelsea and Inter Milan this week and the panel praise Pochettino for not playing the percentages. Next up is the North London derby. The battle between Ozil and Eriksen could be crucial but how much longer will those players be at their respective clubs?Looking ahead to the Merseyside derby, and with Liverpool losing away in the Champions League again, do they lack a dominant figure in midfield? And can Sigurdsson seize control on Sunday for Everton? Plus it’s another week of Mourinho behaving erratically. No Pogba, Lukaku or Sanchez selected for the Champions League clash with Young Boys. Should United have done their research before signing Sanchez? Should Mourinho have been more careful in his reaction to Rashford? And is he fuelling the negativity around the club?Charlie Scott and Paddy von Behr provide their advice ahead of the fantasy football weekend. For free Fantasy Premier League tips from The Sweeper, visit thetimes.co.uk/fantasyfootball See acast.com/privacy for privacy and opt-out information.
Gab Marcotti is joined by Paul Hirst, Gary Jacob and Bill Edgar after a big weekend of football and ahead of a big week to come. With Cristiano Ronaldo returning to Old Trafford with Juventus, Lucy Holden has been to Turin and his birthplace Madeira to study the devotion to a football icon, in the midst of rape allegations that Ronaldo has denied. After a fiery conclusion to Chelsea’s draw with Manchester United, does Jose Mourinho deserve respect from Blues fans just because he was successful at Stamford Bridge? Newcastle lose their 5th home game in a row and are still winless this season. Does Benitez deserve more blame? Or do Newcastle’s problems as a football club pre-date Mike Ashley? Fulham were the 5th biggest net spenders in Europe in the summer. Yet they lost to Cardiff. Did they really need to go out and buy a whole new squad in the summer? And how much longer will Slavisa Jokanovic be at Craven Cottage? See acast.com/privacy for privacy and opt-out information.
Gab Marcotti is joined by Gary Jacob and Paul Hirst after a Premier League weekend that asks a lot of questions. Manchester United’s defeat at Brighton raises issues over United’s defence. The panel discuss how Ed Woodward and Jose Mourinho can’t agree on certain players in the squad and the effect that has on their relationship.We saw 25 minutes of Sarri-ball during a bonkers victory for Chelsea over Arsenal. Will Sarri stick with a system that forces N’Golo Kante to neglect his defensive responsibilities? And on the Arsenal side of things, Pierre-Emerick Aubameyang is a big-name player but is he a big-game player? Plus what does Unai Emery do with the turgid Mesut Ozil?Martyn Ziegler speaks to us about how far we are from VAR in the Premier League and reveals why the 39th game might not be as far away as we think.And even though Natalie Sawyer is on holiday, there are still bragging rights up for grabs. Who was victorious in the first week of match predictions? Gab or Natalie? See acast.com/privacy for privacy and opt-out information.
Gab Marcotti is joined by Gary Jacob and James Scowcroft to discuss the future of Alexis Sanchez, the resurgence of Zaha & Sakho and the indiscipline of Ross Barkley. Discover more at www.thetimes.co.uk. See acast.com/privacy for privacy and opt-out information.
This week, Steve, Allan, Al and Ken welcome Gary Jacob, organizer and producer of the Abbey Road on the River Beatles festival making his first appearance on "Things We Said Today." Gary talks about the history of the event and gives some great behind-the-scenes insight into how it works. And with this week's show, we're adding a new affiliate WCPR. (Their website is http://www.wcpr1.com). On WCPR, you can hear the show for the first time at 9 p.m. ET Thursdays, then repeating 9 a.m. and 9 p.m. Fridays, live on iTunes and on demand beginning on Saturdays. We're also on Fab4Radio.com and PurePopRadio.com.
Rory Smith is joined by Julien Laurens, Tony Cascarino and Gary Jacob. See acast.com/privacy for privacy and opt-out information.