Podcast appearances and mentions of Isabelle M Mansuy

"Die Chancen der Epigenetik für ein gesundes und glückliches Leben" lautet der Untertitel eines Buches der Professorin für Neuroepigenetik an der Universität Zürich und der Eidgenössischen Technischen Hochschule (ETH), Isabelle M. Mansuy. In ihrem Labor untersucht Mansuy, die zu den renommiertesten Forschern auf diesem Gebiet gehört, "auf höchstem internationalem Niveau die epigenetischen Grundlagen komplexer Gehirnfunktionen und wie erworbene Verhaltensweisen über Generationen bei Säugetieren übertragen werden." In unserem Gespräch geht es um den praktischen und vor allem gesellschaftlichen Bezug ihrer Forschung, denn egal ob im Bereich der Politik, Wissenschaft, Medien oder Wirtschaft, immer handeln dort Menschen und treffen Entscheidungen. Dass dieses Verhalten und persönliche Eigenschaften nur durch das Erbgut zu erklären sind, ist längst überholt. Denn "die Epigenetik lehrt: Erfahrungen und unser Lebensstil steuern unser Erbgut. Stress, Trauma, Ernährung und Umwelteinflüsse entscheiden darüber, ob unsere Gene aktiviert oder deaktiviert werden und bestimmen so unser Schicksal und das unserer Kinder und Enkel." Mit Frau Mansuy spreche ich über die Bedeutung von Traumata beziehungsweise prägenden Erfahrungen in der Kindheit für unsere Gesellschaft, über die generationsübergreifende Weitergabe von Trauma und über die epigenetische Bedeutung von Ernährung und Umwelteinflüssen. Ein wenig besprochenes Thema, welches jedoch jeden Menschen betrifft. Das Gespräch fand auf Englisch statt und wurde mit deutschen Untertiteln unterlegt. Artikel und Podcast: https://blog.bastian-barucker.de/epigenetik-mansuy/ Produktionskosten: ca. 1150 € Interviews finanzieren: https://blog.bastian-barucker.de/unterstuetzung/

Autor: Lange, Michael Sendung: Forschung aktuell Hören bis: 19.01.2038 04:14

Autor: Lange, Michael Sendung: Forschung aktuell Hören bis: 19.01.2038 04:14

Autor: Lange, Michael Sendung: Forschung aktuell Hören bis: 19.01.2038 04:14

Une équipe de chercheurs issue de l'Université de Zürich (UZH) a découvert que les expériences traumatisantes vécus durant l'enfance impactent non seulement la composition du sang, mais ces blessures psychiques marquent également l'ADN des futures progénitures. Pour en parler, Huma Khamis reçoit Isabelle M. Mansuy, professeur de neuroépigénétique à la Faculté de médecine de l'Université de Zurich et au Département des sciences et technologies de la santé de l'École polytechnique fédérale de Zurich.

In this episode of the Epigenetics Podcast, we caught up with Professor Isabelle Mansuy, Ph.D., from the University of Zürich and the ETH Zürich, to talk about her work on epigenetic influences on memory formation and inheritance.   Dr. Mansuy received her Ph.D. from the Friedrich Miescher Institute, Basel, Switzerland in 1994. After doing a postdoc at the Center for Neurobiology and Behavior at the Howard Hughes Medical Institute at the Columbia University in New York, she moved to Zürich and became Assistant Professor in Neurobiology at the Department of Biology at the Swiss Federal Institute of Technology in 1998. In 2004 Dr. Mansuy became Professor at the Brain Research Institute of the University Zurich, where, in 2007, she became Managing Director. Since 2013 she has been a full Professor in Neuroepigenetics at the University of Zürich and at the ETH in Zürich.   Dr. Isabelle Mansuy's work centers around the formation of memories and how those memories are inherited. She started to work on memory formation in the beginning of her research career, where she investigated the influence of calcineurin and Zif268 in this process. In the early 2010s she pivoted and transitioned to work on transgenerational epigenetic inheritance. To investigate this field of research she created an unbiased experiment that allowed her to study the transgenerational influence of early life stress, which she was able to observe for across up to 4 generations through the germline.   If you want to learn more about the challenges and obstacles that needed to be overcome to create this novel experimental approach to tackle the questions of and which epigenetic factors might influence transgenerational epigenetic inheritance, don't miss out on this episode.     References Karsten Baumgärtel, David Genoux, … Isabelle M. Mansuy (2008) Control of the establishment of aversive memory by calcineurin and Zif268 (Nature Neuroscience) DOI: 10.1038/nn.2113 Tamara B. Franklin, Holger Russig, … Isabelle M. Mansuy (2010) Epigenetic Transmission of the Impact of Early Stress Across Generations (Biological Psychiatry) DOI: 10.1016/j.biopsych.2010.05.036 Johannes Gräff, Bisrat T. Woldemichael, … Isabelle M. Mansuy (2012) Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation (Nature Communications) DOI: 10.1038/ncomms1997 Eloïse A. Kremer, Niharika Gaur, … Isabelle M. Mansuy (2018) Interplay between TETs and microRNAs in the adult brain for memory formation (Scientific Reports) DOI: 10.1038/s41598-018-19806-z Katharina Gapp, Ali Jawaid, … Isabelle M. Mansuy (2014) Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice (Nature Neuroscience) DOI: 10.1038/nn.3695 Katharina Gapp, Saray Soldado-Magraner, … Isabelle M. Mansuy (2014) Early life stress in fathers improves behavioural flexibility in their offspring (Nature Communications) DOI: 10.1038/ncomms6466 Contact   Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on Linked-In Active Motif on Facebook eMail: podcast@activemotif.com

Welcome to Episode 3! It took us a bit longer to get this out than we would have liked, but the holidays definitely messed up our schedule and there is a lot of research we wanted to get together to share during the episode and to put in the show notes. We appreciate your patience!!In this episode we discuss the biological reason that we might, as human animals, be inclined to put ourselves and our offspring through painful ordeals. We ponder what exactly the benefits of such experience might be and also why we continue to do so today.We thank everyone for their continued support! Please be sure to subscribe to the podcast so you'll see as soon as we post a new podcast! We really appreciate the feedback we have gotten so far, so please let us know if there is anything we can do to improve the podcast, or if there is anything that you are loving about what we're doing. If you have any questions or comments, you can always email us at artanddiscordstudios@gmail.com.Reference Notes:Bastian, Brock, Jolanda Jetten, and Fabio Fasoli. "Cleansing the Soul by Hurting the Flesh." Psychological Science 22.3 (2011): 334-335.Bastian, Brock, Jolanda Jetten, and Laura J. Ferris. "Pain as Social Glue." Psychological Science 25.11 (2014): 2079-2085.Bergland, Christopher. “New Clues on Rewiring Your Brain.” Psychology Today March 28, 2012, www. Psychology today.com/us/blog/the-athletes-way/201203/new-clues-rewiring-your-brainCraig, A.D. “A New View of Pain as a Homeostatic Emotion.” Trends in Neurosciences 26 (2003): 303-307.Day, Melissa A, Charles LWard, M DawnEhde, E BeverlyThorn, John Burns, Amanda Barnier, B JasonMattingley, and P MarkJensen. "A Pilot Randomized Controlled Trial Comparing Mindfulness Meditation, Cognitive Therapy, and Mindfulness-Based Cognitive Therapy for Chronic Low Back Pain." Pain Medicine Advance Article (2019).Fischer, Ronald, and Dimitris Xygalatas. "Extreme Rituals as Social Technologies." Journal of Cognition and Culture 14.5 (2014): 345-355.Gapp, Katharina, Ali Jawaid, Peter Sarkies, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska, and Isabelle M Mansuy. "Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice." Nature Neuroscience 17.5 (2014): 667-669.Henrich, Joseph. "The evolution of costly displays, cooperation and religion." Evolution and Human Behavior 30.4 (2009): 244-260Hughes, Virginia. "Sperm RNA carries marks of trauma." Nature 508.7496 (2014): 296-297.Levi-Strauss, Claude, The Raw and the Cooked. Introduction to a Science of Mythology. Volume I., (1969).Stein, Murray B., Laura Campbell‐Sills, and Joel Gelernter. "Genetic variation in 5HTTLPR is associated with emotional resilience." American Journal of Medical Genetics part B 150B.7 (2009): 900-906.Tatta, Dr. Joe. “How the Brain Creates Pain— and How to Stop It.” Integrative Pain Science Institute Blog. www.integrativepainscienceinstitute.com/brain-create-pain-stopTurner, Victor, “Body, Brain, and Culture” Zygon Journal of Religion and Science. Volume 18, issue 3, Sept 1983, p.221-245.Vågerö, Denny, and Kristiina Rajaleid. "Does childhood trauma influence offspring's birth characteristics?." International Journal of Epidemiology 46.1 (2017).