Podcasts about aims to

Asgard NOTT: L-band nulling interferometry at the VLTI I Simulating the expected high-contrast performance by Romain Laugier et al. on Monday 21 November Context: NOTT (formerly Hi-5) is a new high-contrast L' band (3.5-4.0 textmu m) beam combiner for the VLTI with the ambitious goal to be sensitive to young giant exoplanets down to 5 mas separation around nearby stars. The performance of nulling interferometers in these wavelengths is affected both by fundamental noise from the background and by the contributions of instrumental noises. This motivates the development of end-to-end simulations to optimize these instruments. Aims: To enable the performance evaluation and inform the design of such instruments on the current and future infrastructures, taking into account the different sources of noise, and their correlation. Methods: SCIFYsim is an end-to-end simulator for single mode filtered beam combiners, with an emphasis on nulling interferometers. It is used to compute a covariance matrix of the errors. Statistical detection tests based on likelihood ratios are then used to compute compound detection limits for the instrument. Results: With the current assumptions on the performance of the wavefront correction systems, the errors are dominated by correlated instrumental errors down to stars of magnitude 6-7 in the L band, beyond which thermal background from the telescopes and relay system becomes dominant. Conclusions: SCIFYsim is suited to anticipate some of the challenges of design, tuning, operation and signal processing for integrated optics beam combiners. The detection limits found for this early version of NOTT simulation with the unit telescopes are compatible with detections at contrasts up to $10^5$ in the L band at separations of 5 to 80 mas around bright stars. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.09548v1

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.25.513669v1?rss=1 Authors: Swinkels, M., Hordijk, S., Bürgisser, P. E., Slotman, J. A., Carter, T., Leebeek, F. W. G., Jansen, A. J. G., Voorberg, J., Bierings, R. Abstract: Background: Platelet alpha-granules contain Von Willebrand factor (VWF), which is stored in eccentric alpha-granule nanodomains, and VWF propeptide (VWFpp). Differential release of VWF and VWFpp has been reported from endothelial cells. It is unclear if this also occurs during platelet alpha-granule exocytosis. We have recently developed a 3D super-resolution imaging workflow for quantification of platelet alpha-granule content based on Structured Illumination Microscopy (SIM). With this we can study alpha-granule cargo release following platelet activation in hundreds of platelets simultaneously. Aims: To study release of VWF and VWFpp from alpha-granules using quantitative super-resolution microscopy. Methods: Platelets were activated with PAR-1 activating peptide (PAR-1 ap) or collagen-related peptide (CRP-XL). Alpha-tubulin, VWF, VWFpp, SPARC and fibrinogen were imaged using 3D-SIM, followed by semi-automated analysis in FIJI. Uptake of anti-VWF nanobody during degranulation was used to identify alpha-granules that partially released content. Results: VWF+ and VWFpp+ structures overlapped nearly completely (~90%) in resting platelets, implying they are stored in similar eccentric alpha-granule nanodomains. A subset of VWF+/VWFpp+-structures was released completely at 0.6 M PAR-1-ap, but at higher concentration (20 M) significantly more VWFpp (85.3{+/-}1.6%) was released than VWF (37.6{+/-}1.4%). Release of other cargo was intermediate at 20 M (SPARC: 62.2{+/-}1.4% ; fibrinogen: 51.9{+/-}2.9%), providing further evidence for differential cargo release. Similar results were obtained using CRP-XL. Anti-VWF nanobody was taken up by VWF+/VWFpp- structures and increased with stimulus strength, demonstrating these were post-exocytotic structures. Conclusions: VWF and VWFpp are differentially released from alpha-granules. This may affect how platelet-derived VWF and VWFpp contribute to formation and stabilization of hemostatic clots. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Satellite galaxy abundance dependency on cosmology in Magneticum simulations by Antonio Ragagnin et al. on Sunday 18 September Context: Modelling satellite galaxy abundance $N_s$ in Galaxy Clusters (GCs) is a key element in modelling the Halo Occupation Distribution (HOD), which itself is a powerful tool to connect observational studies with numerical simulations. Aims: To study the impact of cosmological parameters on satellite abundance both in cosmological simulations and in mock observations. Methods: We build an emulator (HODEmu, url{https://github.com/aragagnin/HODEmu/}) of satellite abundance based on cosmological parameters $Omega_m, Omega_b, sigma_8, h_0$ and redshift $z.$ We train our emulator using magneticum hydrodynamic simulations that span 15 different cosmologies, each over $4$ redshift slices between $0

Aims: To abolish the unfair Treaty of Versailles (diktat), reclaim the lost lands and get revenge against the Allies To unite all German-speaking people To check the spread of Communism To expand to the East for Lebensraum To revive military and national pride To strengthen existing alliances for expansion In the coming months, I will be studying for the A-Level History examinations. Each topic/theme will have its own podcast series. For paper 3, I am studying the Holocaust. For paper 4, I am studying the European option. Theme 1: Mussolini's Italy, 1919–41 Theme 2: Stalin's Russia, 1924–41 Theme 3: Hitler's Germany, 1929–41 If you want some more revision material, you can use the link below to access much more revision information on my website: https://sites.google.com/view/igcse-history-revision/home If you have any suggestions or questions, please fill in this Google Form: https://forms.gle/caEki6L8SzS6wwui7 Become a Paid Subscriber: https://anchor.fm/from1student2another-hist/subscribe Please support and help me improve with a small monthly subscription :) Subscribers can email me at robinjww04historypodcast@gmail.com to let me know what they would like me to feature in these special episodes. CONTACT ME: Send in a voice message: https://anchor.fm/from1student2another-hist/message Twitter: https://twitter.com/historyF1S2A Instagram: https://www.instagram.com/from1student2anotherhistory/ Email: robinjww04historypodcast@gmail.com THANKS FOR YOUR INTEREST IN MY PODCAST! Please subscribe to be notified about any future releases.

Use the video perceptual activities at home (great recommendation for teletherapist) and when we all return to the school settings. Check it out! Aims: To develop visual-perceptual skills:  Spatial relations  Figure-ground perception  Form constancy  Visual memory

An Actual play of Hearts of Wulin inspired by The WAter MArgin and a little of Saban's Power Rangers - that's gotta work right! Session 1 of 4: CATS: Concept: A blend of Hearts of Wulin meets the Watch with big eyes towards the Water Margin with a tinge of Seven Samurai for theme and style. Strange bedfellows against a powerful evil. Outlaws skilled in forbidden martial arts fighting to survive. Between each session - time will pass. Aims: To tell the episodic story of wandering rebels fighting against the forces of corruption and oppression. Between each session - time will pass. This will allow the world to change around us and for the 'heroes' to shine in moments of high drama Tone: Grim - but players are free to inject humor when appropriate. Themes of imperialism, corruption, loss, and hardship will be explored. Subject Matter: A Wuxia drama that is set in a dark time. We will explore, authoritarian oppression, heroism, the hero's journey (and failure) and the effect of tyranny on those you love and hate

Impact of Specialized Inpatient IBD Care on Outcomes of IBD Hospitalizations: A Cohort Study Law, Cindy C. Y. MD; Sasidharan, Saranya MD; Rodrigues, Rodrigo MD; Nguyen, Deanna D. MD; Sauk, Jenny MD; Garber, John MD; Giallourakis, Cosmas MD; Xavier, Ramnik MD, PhD; Khalili, Hamed MD, MPH; Yajnik, Vijay MD, PhD; Ananthakrishnan, Ashwin N. MD, MPH Host: Dr. Manish Singla, Gastroenterology Division, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD Background: The management of inflammatory bowel diseases (IBDs; Crohn's disease, ulcerative colitis) is increasingly complex. Specialized care has been associated with improved ambulatory IBD outcomes. Aims: To examine if the implementation of specialized inpatient IBD care modified short-term and long-term clinical outcomes in IBD-related hospitalizations. Methods: This retrospective cohort study included IBD patients hospitalized between July 2013 and April 2015 at a single tertiary referral center where a specialized inpatient IBD care model was implemented in July 2014. In-hospital medical and surgical outcomes as well as postdischarge outcomes at 30 and 90 days were analyzed along with measures ...

Impact of Specialized Inpatient IBD Care on Outcomes of IBD Hospitalizations: A Cohort Study Law, Cindy C. Y. MD; Sasidharan, Saranya MD; Rodrigues, Rodrigo MD; Nguyen, Deanna D. MD; Sauk, Jenny MD; Garber, John MD; Giallourakis, Cosmas MD; Xavier, Ramnik MD, PhD; Khalili, Hamed MD, MPH; Yajnik, Vijay MD, PhD; Ananthakrishnan, Ashwin N. MD, MPH Host: Dr. Manish Singla, Gastroenterology Division, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD Background: The management of inflammatory bowel diseases (IBDs; Crohn's disease, ulcerative colitis) is increasingly complex. Specialized care has been associated with improved ambulatory IBD outcomes. Aims: To examine if the implementation of specialized inpatient IBD care modified short-term and long-term clinical outcomes in IBD-related hospitalizations. Methods: This retrospective cohort study included IBD patients hospitalized between July 2013 and April 2015 at a single tertiary referral center where a specialized inpatient IBD care model was implemented in July 2014. In-hospital medical and surgical outcomes as well as postdischarge outcomes at 30 and 90 days were analyzed along with measures ...

Impact of Specialized Inpatient IBD Care on Outcomes of IBD Hospitalizations: A Cohort Study Law, Cindy C. Y. MD; Sasidharan, Saranya MD; Rodrigues, Rodrigo MD; Nguyen, Deanna D. MD; Sauk, Jenny MD; Garber, John MD; Giallourakis, Cosmas MD; Xavier, Ramnik MD, PhD; Khalili, Hamed MD, MPH; Yajnik, Vijay MD, PhD; Ananthakrishnan, Ashwin N. MD, MPH Host: Dr. Manish Singla, Gastroenterology Division, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD Background: The management of inflammatory bowel diseases (IBDs; Crohn's disease, ulcerative colitis) is increasingly complex. Specialized care has been associated with improved ambulatory IBD outcomes. Aims: To examine if the implementation of specialized inpatient IBD care modified short-term and long-term clinical outcomes in IBD-related hospitalizations. Methods: This retrospective cohort study included IBD patients hospitalized between July 2013 and April 2015 at a single tertiary referral center where a specialized inpatient IBD care model was implemented in July 2014. In-hospital medical and surgical outcomes as well as postdischarge outcomes at 30 and 90 days were analyzed along with measures ...

Impact of Specialized Inpatient IBD Care on Outcomes of IBD Hospitalizations: A Cohort Study Law, Cindy C. Y. MD; Sasidharan, Saranya MD; Rodrigues, Rodrigo MD; Nguyen, Deanna D. MD; Sauk, Jenny MD; Garber, John MD; Giallourakis, Cosmas MD; Xavier, Ramnik MD, PhD; Khalili, Hamed MD, MPH; Yajnik, Vijay MD, PhD; Ananthakrishnan, Ashwin N. MD, MPH Host: Dr. Manish Singla, Gastroenterology Division, Department of Internal Medicine, Walter Reed National Military Medical Center, Bethesda, MD Background: The management of inflammatory bowel diseases (IBDs; Crohn's disease, ulcerative colitis) is increasingly complex. Specialized care has been associated with improved ambulatory IBD outcomes. Aims: To examine if the implementation of specialized inpatient IBD care modified short-term and long-term clinical outcomes in IBD-related hospitalizations. Methods: This retrospective cohort study included IBD patients hospitalized between July 2013 and April 2015 at a single tertiary referral center where a specialized inpatient IBD care model was implemented in July 2014. In-hospital medical and surgical outcomes as well as postdischarge outcomes at 30 and 90 days were analyzed along with measures ...

Aims: To investigate if vaginal application of dequalinium chloride (DQC, Fluomizin (R)) is as effective as vaginal clindamycin (CLM) in the treatment of bacterial vaginosis (BV). Methods:This was a multinational, multicenter, single-blind, randomized trial in 15 centers, including 321 women. They were randomized to either vaginal DQC tablets or vaginal CLM cream. Follow-up visits were 1 week and 1 month after treatment. Clinical cure based on Amsel's criteria was the primary outcome. Secondary outcomes were rate of treatment failures and recurrences, incidence of post-treatment vulvovaginal candidosis (VVC), lactobacillary grade (LBG), total symptom score (TSC), and safety. Results: Cure rates with DQC (Cl: 81.5%, C2: 79.5%) were as high as with CLM (Cl: 78.4%, C2: 77.6%). Thus, the treatment with DQC had equal efficacy as CLM cream. A trend to less common post-treatment VVC in the DQC-treated women was observed (DQC: 2.5%, CLM: 7.7%; p = 0.06). Both treatments were well tolerated with no serious adverse events occurring. Conclusion: Vaginal DQC has been shown to be equally effective as CLM cream, to be well tolerated with no systemic safety concerns, and is therefore a valid alternative therapy for women with BV {[}ClinicalTrials.gov, Med380104, NCT01125410]. Copyright (C) 2011 S. Karger AG, Basel

Background: The 22q13 deletion syndrome (Phelan– McDermid syndrome) is characterised by a global developmental delay, absent or delayed speech, generalised hypotonia, autistic behaviour and characteristic phenotypic features. Intranasal insulin has been shown to improve declarative memory in healthy adult subjects and in patients with Alzheimer disease. Aims: To assess if intranasal insulin is also able to improve the developmental delay in children with 22q13 deletion syndrome. Methods: We performed exploratory clinical trials in six children with 22q13 deletion syndrome who received intranasal insulin over a period of 1 year. Short-term (during the first 6 weeks) and long-term effects (after 12 months of treatment) on motor skills, cognitive functions, or autonomous functions, speech and communication, emotional state, social behaviour, behavioural disorders, independence in daily living and education were assessed. Results: The children showed marked short-term improvements in gross and fine motor activities, cognitive functions and educational level. Positive long-term effects were found for fine and gross motor activities, nonverbal communication, cognitive functions and autonomy. Possible side effects were found in one patient who displayed changes in balance, extreme sensitivity to touch and general loss of interest. One patient complained of intermittent nose bleeding. Conclusions: We conclude that long-term administration of intranasal insulin may benefit motor development, cognitive functions and spontaneous activity in children with 22q13 deletion syndrome.

Aims: To assess temporal trends in birth weight and pregnancy weight gain in Bavaria from 2000 to 2007. Methods: Data on 695,707 mother and infant pairs (singleton term births) were available from a compulsory reporting system for quality assurance, including information on birth weight, maternal weight at delivery and at booking, maternal smoking, age, and further anthropometric and lifestyle factors. Pregnancy weight gain was defined as: weight prior to delivery minus weight at first booking minus weight of the newborn. Results: Although mean weight gain during pregnancy increased considerably from 10.10 to 10.73 kg in seven years, the mean birth weight in mature singletons decreased slightly from 3433 to 3414 g. These trends could not be explained by concurrent changes in the rates of primiparity, smoking and gestational diabetes. Conclusions: These German data confirm an increased weight gain during pregnancy with adjustment for potential confounders.

Background: A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80--100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO).Aims: To evaluate whether MRZR distinguishes NMO and MS.Methods: 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and varicella zoster virus was detected by calculation of the respective antibody indices (AI).Results: A positive MRZ reaction, as defined by a combination of at least two positive AIs, was found in 37/42 MS, but in only 1/20 NMO patients (p

Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying.Aims: To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-1 receptor antagonist exendin(9-39)amide (ex(9-39)NH2).Methods: Nine healthy volunteers underwent four experiments each. In two experiments with and without intravenous infusion of ex(9-39)NH2 300 pmol/kg/min, a fasting period was followed by intraduodenal glucose perfusion at 1 and 2.5 kcal/min, with the higher dose stimulating GLP-1 release. Antro-pyloro-duodenal motility was measured by perfusion manometry. To calculate the incretin effect (that is, the proportion of plasma insulin stimulated by intestinal hormones) the glycaemia observed during the luminal glucose experiments was mimicked using intravenous glucose in two further experiments.Results: Ex(9-39)NH2 significantly increased glycaemia during fasting and duodenal glucose. It diminished plasma insulin during duodenal glucose and significantly reduced the incretin effect by approximately 50%. Ex(9-39)NH2 raised plasma glucagon during fasting and abolished the decrease in glucagon at the high duodenal glucose load. Ex(9-39)NH2 markedly stimulated antroduodenal contractility. At low duodenal glucose it reduced the stimulation of tonic and phasic pyloric motility. At the high duodenal glucose load it abolished pyloric stimulation.Conclusions: Endogenous GLP-1 stimulates postprandial insulin release. The pancreatic textgreeka cell is under the tonic inhibitory control of GLP-1 thereby suppressing postprandial glucagon. GLP-1 tonically inhibits antroduodenal motility and mediates the postprandial inhibition of antral and stimulation of pyloric motility. We therefore suggest GLP-1 as a true incretin hormone and enterogastrone in humans.