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Send us Fan Mail summaryIn this episode of the Tracheostomy Education Podcast, Nicole DePalma continues the two-part discussion on decannulation with Dr. Jerry Gentile. This episode focuses on what happens after a patient is tolerating capping, how long to monitor before trach removal, the role of FEES in evaluating secretion management and aspiration risk, and what clinicians should know about failed or accidental decannulation. Nicole and Jerry discuss the importance of assessing whether the original reason for the tracheostomy has resolved, whether the patient can manage secretions, and whether there is adequate upper airway patency. Nicole explains how Flexible Endoscopic Evaluation of Swallowing, or FEES, can help evaluate secretion management, aspiration, cough strength, sensation, swallowing safety, and airway patency when determining whether a patient is ready for decannulation from a SLP perspective. The conversation also covers the transition from capping to trach removal, including monitoring patients for 24 to 72 hours, watching for increased work of breathing, changes in CO₂, oxygen saturation, respiratory rate, coughing ability, and aspiration concerns. Jerry explains what happens after the trach is removed, how the stoma is covered, and why patients may need continued monitoring after decannulation. Nicole and Jerry also review failed decannulation, signs that a patient may need recannulation, and the risks associated with accidental decannulation. They discuss when clinicians should call respiratory therapy, why reinserting a trach can be dangerous if not done correctly, and complications such as false tracking and subcutaneous emphysema. Topics covered in this episode include: The role of FEES in decannulation readiness Secretion management and aspiration risk Airway patency and when to involve ENT Capping trials and 24–72 hour monitoring Oxygen delivery during speaking valve use, capping, and after decannulation Stoma care after trach removal Failed decannulation and signs of respiratory decline Accidental decannulation and when to call respiratory therapy Risks of false tracking and subcutaneous emphysema Pediatric considerations for decannulationSupport the showhttps://tracheostomyeducation.cominstagram.com/tracheostomyeducationlinkedin.com/in/nicole-de-palma-708b16blinkedin.com/in/dr-jerry-gentile
In this episode, we review the high-yield topic of Gastric Secretion from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
What if every line in the Book of Revelation was never about the end of the world — but about what's happening inside your own body right now?Kelly Marie Kerr spent years cross-referencing scripture with biochemistry, Essene cosmology, and ancient yoga, and what she found rewires everything you thought you knew about the Bible. The seven churches map onto your seven chakras. The 33 years of Jesus map onto the 33 vertebrae of your spine. John baptizing Jesus at age 30 lines up — molecule-for-molecule — with thyroxine (chemical symbol I-O-H-N), baptizing your cerebrospinal fluid at the 30th vertebra. The blue oil she saw rising during a spontaneous kundalini event? Almost certainly nitric oxide — the "777 molecule" pairing with oxygen, the "888 molecule" — and 888 just happens to be the gematria value of "Jesus" in Greek.We get into the sacred secretion, the three-and-a-half-day moon transit window, why your pineal gland is calcified, what a real Christed state actually feels like, and the 33% of human consciousness she believes will tip the planet into a different timeline.If you grew up scared of Revelation, this conversation will unscare you.
Most people hear about kambo and think it's reckless and dangerous, until they see what happens when it's done right.My understanding of kambo changed a lot through this conversation, especially after hearing how it's been used not just as a traditional Amazonian medicine, but also as a tool for addressing complex health challenges. Caitlin Thompson brings a rare blend of experience to this space, having served thousands of sessions while also approaching the work through a scientific lens rooted in neurobiology and research.Her path into frog medicine came from navigating her own history with Lyme disease, lupus, and chronic illness, which gives real context to why she approaches this work with both precision and respect. We get into what kambo healing looks like in practice, including how dosage, safety, and nervous system state can completely change the outcome of a session.There's also a deeper conversation around why many people have overwhelming experiences, and how a more intentional, minimalist approach can unlock benefits around immune support, chronic illness recovery, and nervous system healing.This is a grounded look at ancient tools meeting modern science, and what becomes possible when healing is approached with both rigor and humility.Visit kambospecialist.com and use code LS10 for 10% off all online courses and ebooks.THE LIFE STYLIST IS BROUGHT TO YOU BY:LEELA QUANTUM | Go to lukestorey.com/leelaq and use code LUKE10 for 10% off your first order.BIOPTIMIZERS | Visit bioptimizers.com/luke and use code LUKE15 to save 15% off sitewide.PIQUE | Visit piquelife.com/luke to get 15% off for life when you subscribe.REAL PROVISIONS | Visit realprovisions.com/luke and use code LUKE to get a free bag of Venison Chips with your order.You'll learn:[00:00] Introduction[10:06] Frog medicine 101: what it is, what it does, and how it's collected[15:32] Nobody actually knows who discovered kambo first[27:52] Why doing more kambo doesn't mean getting more out of it[40:05] How Caitlin's personal relationship with kambo has evolved over a decade[52:41] What's happening to frog populations and the communities behind the medicine[01:05:54] Mixing kambo with psychedelics is riskier than most people think[01:13:58] Who should and shouldn't take kambo, and what it can do for addiction[01:36:21] Treating Lyme without addressing trauma may be why people don't get better[01:50:31] Is it the substance that's intelligent or something working through it?Resources mentioned:Phyllomedusa bicolor | WebsiteMatsés | WebsiteSananga WebsiteRapé | Website Read: Thompson et al, Use of Phyllomedusa bicolour secretion during kambô ritual: observational responses, dosage, and risk of adverse events | ArticleRead: Thompson & Williams, Review of the physiological effects of Phyllomedusa bicolor skin secretion peptides on humans receiving Kambô | ArticleInstitute of Kambo Advancement and Preservation WebsitePeter Gorman Website Read: WTFrog Is Kambo and Am I Ready: A Practical Guide to Understanding the Experience, Staying Safe, and Evaluating If Kambo Is Right For You | BookTodd Shipman Website Full show notes at lukestorey.com/kamboFind more from Caitlin:Medicine Frog Kambo | Website | Instagram | Facebook | YouTubeMedicine Frog Kambo Practitioner Training | WebsiteInstitute of Kambo Advancement and Preservation (IKAP) | WebsiteKambocon | WebsiteFind more from Luke:Luke Storey | Instagram | Facebook | X | YouTube | LinkedIn
Become a master of cortisol and learn how to identify and treat a common condition in patients with adrenal tumors! Join us as we learn about mild autonomous cortisol secretion (MACS) with Dr. Irina Bancos (@irinabancos), an internationally renowned adrenal expert!Claim CME for this episode at curbsiders.vcuhealth.org!Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CMEShow Segments Intro Advice for listeners Adrenal incidentaloma Definition (Case 1) Hormonal workup for adrenal incidentalomas Defining mild autonomous cortisol secretion (MACS) Significance and prevalence of MACS Diagnostic testing for MACS Treatment options for MACS (surgery vs. comorbidity management) Post surgical management of MACS (Case 2) Diagnostic testing for adrenal insufficiency (AI) Glucocorticoid withdrawal syndrome management Deciding when patients are able to come off of steroids after AI Outcomes after adrenalectomy in MACS Take home points CreditsWritten and produced by Paul Wurtz MD. Show notes, cover art, and infographic also created by Paul Wurtz MD. Producer, writer, show notes, and CME: Mobeen Ahmad MD Cover art and infographic: Kate Grant MBChb, MRCGP Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP; Mobeen Ahmad MD Reviewer: Emi Okamoto MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Irina Bancos MD, MSc DisclosuresDr. Bancos has the following disclosures: Consulting, advisory board or safety monitoring board (all fees to institution): Recordati, Corcept, Esteve, Spruce, Sparrow, Diurnal, Neurocrine, Lufordi, Adaptyx, Crinetics, Xeris, AstraZeneca, NovoNordisc, Camurus. Research grant for investigator initiated research (to institution): Esteve, Recordati Sponsor: Panacea FinancialVisit PanaceaFinancial.com today to claim your $100 bonus and start banking built for the way you actually live and work.Sponsor: MasterClassRight now, as a listener of this show, you get at least 15% off any annual membership at MASTERCLASS.com/CURB.Sponsor: Branch Basics Use code [CURB] for 15% off the Premium Starter Kit at BranchBasics.com.
What if the human body isn't just self-healing… but cyclical, rhythmic, and far more capable than we've been led to believe?In this episode, we sit down with R. Sage to explore what he calls the body's “hidden cycle” – a monthly, internal process tied to lunar rhythms, the brain, and the nervous system. Often referred to as the sacred secretion, this phenomenon is described as a natural, recurring event within the human body; one that may support regeneration, clarity, and expanded awareness when properly understood and supported. From a Terrain perspective, this opens up a deeper layer of the conversation:If health is about removing interference and aligning with natural law… what happens when we begin to consider not just what we put into the body – but when, how, and in what state we live?Throughout this conversation, we explore:The connection between lunar cycles and human physiologyThe role of the nervous system, breath, and internal environment in supporting natural processesHow modern lifestyle factors—from diet to stress to environmental inputs—may interfere with the body's innate rhythmsThe importance of stillness, fasting, and reducing input to allow the body to do what it's designed to doHow R Sage used this "hidden cycle" to expand his consciousness and unlock incredible, almost unbelievable abilitiesAnd how awareness itself may be one of the most overlooked aspects of tending the terrainWhether you view this through a physiological lens, a spiritual one, or somewhere in between, this episode invites a broader question:Is the terrain just something we cleanse and support…or is it something we can learn to align with, cycle by cycle, and begin to activate to realize our greatest potential?R. Sage is a researcher, educator, and guide exploring what he describes as the deeper energetic and cyclical processes of the human body, particularly those that have been preserved in ancient traditions but largely excluded from modern health conversations.Learn more about his work at The Sage Den Telegram Channel, https://t.me/thesageden on Youtube at https://www.youtube.com/@thesageden, or on Skool at https://www.skool.com/the-sage-den-7724.Support Terrain Theory on Patreon! Our member platform gives you access to weekly bonus episode content. Check it out: https://www.patreon.com/TerrainTheoryExplore our growing list of intentional Terrain Support products at https://www.terraintheory.net/collections/terrainsupportTerrain Theory episodes are not to be taken as medical advice.If you have a Terrain Transformation story you would like to share, email us at ben@terraintheory.net.Learn more at www.terraintheory.netFollow Terrain Theory:Instagram: https://www.instagram.com/terrain_theory/Facebook: https://www.facebook.com/Terrain-TheoryX: https://twitter.com/terraintheory1YouTube: https://www.youtube.com/@terraintheoryMusic by Chris Merenda
In this encore episode, we detail low stomach acid while reviewing gastric lining anatomy, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential downstream effects of suboptimal stomach acid, including impaired digestive signaling, bacterial overgrowth in the small intestine, and more. Topics: 1. Introduction- Highlighting the stomach and stomach acid, as well as microbial balance, dysbiosis, and overgrowth. 2. Gastric Anatomy and Mucosal Layers- The stomach: cardia, fundus, body, pylorus.- The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae.- The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells.- Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more. 3. Mucous Cells - The surface epithelium and gastric pits.- Secretion of thick, viscous mucus.- Protecting the epithelium.- The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage. 4. Parietal Cells and Gastric Acid Secretion- Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food.- Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum. 5. Chief Cells and Pepsinogen- Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin.- Pepsin and protein digestion.- Release of gastric lipase. 6. Hydrochloric Acid: Digestive and Protective Roles- Immune defense.- Pepsinogen activation.- Adequate gastric acidity essential for properly acidified chyme.- Priming release of bile and pancreatic enzymes. 7. The Small Intestine, Stomach, and Microbial Regulation- The pyloric sphincter.- The stomach supports minimal microbial diversity.- Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine. 8. Hypochlorhydria, Low Stomach Acid- Hypochlorhydria can compromise one of the body's defense mechanisms.- Colonization of the small intestine.- Insufficient pepsinogen activation and possible protein digestion impairment.- Suboptimal chyme formation and downstream digestive capacity.- Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium. 9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis 10. Conclusion- Root-cause approach.Thank you to our episode sponsor: 1. Shop Luxxe Red Light™ here and receive 10% off.* Luxxe Red Light™ panels are for general wellness and are not intended to diagnose, treat, cure, or prevent any disease. *This podcast is for general informational and educational purposes only and should not be used as medical advice. Thanks for tuning in!Get Chloe's Book: "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram: @synthesisofwellnessFollow Chloe on TikTok: @chloe_c_porterVisit synthesisofwellness.com
Contributor: Taylor Lynch MD Educational Pearls: Melatonin is an endogenous hormone released primarily by the pineal gland Also released by extrapineal regions in the retina, the GI tract, and some immune cells Peak secretion occurs at night and is suppressed during the day Secretion and production decrease with age Older patients experience the greatest improvement in sleep latency and sleep quality Mechanism of action in the suprachiasmatic nucleus of the hypothalamus MT1 receptor Reduces normal firing MT2 receptor Shifts the circadian rhythm FDA approved for insomnia Decreases sleep latency by 7 minutes Increases total sleep time by 8 minutes FDA approved for circadian sleep-wake disorders Jet lag Most effective in west-to-east travel Best if crossing at least 5 time zones Shift work A study examined ED physicians and nurses with rotating shifts Modest increase in deep sleep percentage No difference in cognition or reaction time the day after taking melatonin Nurses on rotating night shifts experienced increased total sleep time by 20 minutes Dosing 0.5 - 3 mg is the most evidence-based dosing Higher doses increase the risk of rebound grogginess but do not improve outcomes References Ahmad SB, Ali A, Bilal M, et al. Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders. Cell Mol Neurobiol. 2023;43(6):2437-2458. doi:10.1007/s10571-023-01324-w Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002;(2):CD001520. doi:10.1002/14651858.CD001520 Morgenthaler TI, Lee-Chiong T, Alessi C, Friedman L, Aurora RN, Boehlecke B, Brown T, Chesson AL Jr, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ, Zak R; Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep. 2007 Nov;30(11):1445-59. doi: 10.1093/sleep/30.11.1445. Erratum in: Sleep. 2008 Jul 1;31(7):table of contents. PMID: 18041479; PMCID: PMC2082098. Thottakam BMVJ, Webster NR, Allen L, Columb MO, Galley HF. Melatonin Is a Feasible, Safe, and Acceptable Intervention in Doctors and Nurses Working Nightshifts: The MIDNIGHT Trial. Front Psychiatry. 2020;11:872. Published 2020 Aug 27. doi:10.3389/fpsyt.2020.00872 Summarized and edited by Jorge Chalit, OMS4 Donate: https://emergencymedicalminute.org/donate/ Join our mailing list: http://eepurl.com/c9ouHf
In this encore episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. Topics:1. Hypochlorhydria - Low stomach acid.2. H. pylori 3. Gastric Anatomy & Layers- The stomach: hollow, muscular organ for mechanical and chemical digestion.- Regions: Cardia, fundus, body, and pylorus.- Layers: Mucosa, Submucosa, Muscularis externa, Serosa4. Mucosal Layer - Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.- Gastric pits lead to gastric glands, which contain specialized secretory cells.5. Specialized Gastric Cells- Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).- Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.- Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.- Intrinsic factor and vitamin B12 absorption.6. Vitamin B12 Absorption- Essential for DNA synthesis, RBC formation, neurological function.- Released from food proteins by gastric acid and pepsin.- Impaired absorption.7. Role of Gastric Acid in Broader Micronutrient Absorption- Absorption of minerals.- Soluble, ionized state.- Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.8. Protective Role of Gastric Acid- Acts as a line of defense against ingested pathogens.- Maintains low microbial diversity in the stomach.- Low HCl and Small Intestinal Bacterial Overgrowth.9. Symptoms of Low Stomach Acid- Bloating, early satiety, excessive belching.- Undigested food in stool, chronic constipation.- May reflect impaired enzymatic activation and digestive insufficiency.10. Conclusion- Multifactorial causes and downstream effects.- Optimal range, neither high nor low.Thank you to our episode sponsor: 1. "Longevity" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code CHLOE for 25% off.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
This brief video excerpt provides a concise explanation of the key steps involved in insulin release from pancreatic beta cells in response to elevated blood glucose levels. The process involves a cascade of events triggered by glucose uptake, leading to increased ATP production, altered ion channel activity, calcium influx, and ultimately, insulin secretion.
Wer kennt sie nicht, die sogenannten MACS? Füralle, die hier zurecht die Zebras trappeln hören besprechen wir in dieser Folge eine eher seltene, aber zunehmend entdeckte Konstellation bei Nebennierenraumforderungen. Wir dürfen erstmals Frau Dr. med. Anne Kauffels-Sprenger als Gast begrüßen, welche seit Juli standortübergreifend die universitäre Sektion Endokrine Chirurgie alsSektionsleiterin am UKGM Standort Gießen und als Sektionschefärztin am AGAPLESION das Evangelisches Krankenhaus Gießen leitet. Moderation: Sophie HeislerGast: Dr. med. Anne Kauffels-SprengerBesprochene Publikation:Pelsma ICM, Fassnacht M, Tsagarakis S, TerzoloM, Tabarin A, Sahdev A, Newell-Price J, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM. Comorbidities in mildautonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis. Eur J Endocrinol. 2023 Oct 17;189(4):S88-S101. doi: 10.1093/ejendo/lvad134. PMID: 37801655.
When your body begins to lose its ability to respond to insulin effectively, this condition is known as insulin resistance. It places extra pressure on the beta cells of the pancreas, which are responsible for keeping blood sugar levels between 70 to 140 mg/dL. In a healthy individual, even after consuming something sweet—for example, mango juice—blood sugar gets automatically controlled through the quick response of beta cells, which release extra insulin to restore normal glucose levels. However, frequent consumption of high-calorie, high-sugar, or fatty foods significantly increases the workload on these beta cells. Over time, this constant strain can impair their function, disrupt the body's glucose regulation, and eventually lead to diabetes. Importantly, diabetes is not just a “sugar problem”—it is also a vascular disease. It damages both large and small blood vessels throughout the body: - Large vessel complications include heart attacks (coronary artery disease), strokes (cerebrovascular disease), and leg artery blockages (peripheral artery disease), which can lead to gangrene. - Small vessel complications affect the eyes (diabetic retinopathy), kidneys (diabetic nephropathy), and nerves (diabetic neuropathy), damaging delicate blood vessels of these target organs and impairing vital filtering mechanisms. Thus, diabetes is a chronic, systemic condition that impacts the entire vascular system and requires a comprehensive approach for prevention and management. Expert- Dr Sunil Gupta Anchor- Purva Kulkarni Recorded on: 24/04/2025 Recorded at: Akashwani Nagpur
In this encore episode, we detail hypochlorhydria while reviewing gastric lining anatomy, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential downstream effects of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on possible influences of the oral microbiome and oral dysbiosis.Topics: 1. Introduction- Highlighting the stomach and hypochlorhydria / low stomach acid, as well as microbial balance, dysbiosis, and overgrowth.- Discussion of intestinal microbiome and oral microbiome. 2. Gastric Anatomy and Mucosal Layers- The stomach: cardia, fundus, body, pylorus.- The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae.- The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells.- Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more. 3. Mucous Cells - The surface epithelium and gastric pits.- Secretion of thick, viscous mucus.- Protecting the epithelium.- The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage. 4. Parietal Cells and Gastric Acid Secretion- Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food.- Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum. 5. Chief Cells and Pepsinogen- Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin.- Pepsin and protein digestion.- Release of gastric lipase. 6. Hydrochloric Acid: Digestive and Protective Roles- Immune defense.- Pepsinogen activation.- Adequate gastric acidity essential for properly acidified chyme.- Priming release of bile and pancreatic enzymes. 7. The Small Intestine, Stomach, and Microbial Regulation- The pyloric sphincter.- The stomach supports minimal microbial diversity.- Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine. 8. Hypochlorhydria, Low Stomach Acid- Hypochlorhydria can compromise one of the body's defense mechanisms.- Colonization of the small intestine.- Insufficient pepsinogen activation and possible protein digestion impairment.- Suboptimal chyme formation and downstream digestive capacity.- Possible symptoms of hypochlorhydria.- Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium.- H. pylori infection, autoimmunity, aging. 9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis- Oral and environmental microbes.- Altered gastric pH, bile, digestive enzymes, and more.- The oral cavity as the gateway to the GI tract.- Oral microbial species.- Oral hygiene and oral microbiome health. 10. Conclusion- Root-cause approach.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Uma descoberta surpreendente está emergindo entre usuários de medicamentos GLP-1 como Ozempic e Wegovy: essas drogas revolucionárias para perda de peso não apenas suprimem o apetite, mas estão alterando fundamentalmente como percebemos cheiros.Kara Nesvig, colecionadora de mais de 100 perfumes, descobriu que seus aromas favoritos - especialmente fragrâncias de baunilha que antes evocavam memórias românticas - começaram a provocar náuseas intensas após iniciar tratamento com semaglutida. Sua experiência não é isolada: milhares de usuários relatam mudanças olfativas dramáticas, desde aversão total a perfumes até "fome" por fragrâncias doces.A ciência por trás desse fenômeno é fascinante. O Dr. Hiroaki Matsunami, autoridade mundial em neurobiologia olfativa da Universidade Duke, explica que temos aproximadamente 1.000 tipos de receptores olfativos, cada um detectando moléculas específicas. Pesquisas recentes revelaram que o GLP-1 tem circuitos neurais separados no cérebro - alguns controlam saciedade sem aversão, outros desencadeiam forte repulsa.Cinco teorias científicas explicam as alterações: ruptura do sistema de recompensa cerebral, reprogramação de memórias olfativas, aversão condicionada similar à intoxicação alimentar, hipersensibilidade aos cheiros, e mudanças hormonais comparáveis à gravidez.Estudos controlados confirmam o fenômeno: 85% dos usuários de GLP-1 tiveram pontuações de paladar piores que controles, e paradoxalmente, aqueles com melhor olfato e paladar experimentam mais efeitos colaterais como náusea.A conexão com COVID-19 oferece insights valiosos - assim como o vírus causa alterações olfativas duradouras, os GLP-1 estão reescrevendo nossa percepção sensorial através de vias hormonais.Esta descoberta vai além da curiosidade: pode revolucionar tratamentos personalizados, ajudar no desenvolvimento de terapias para transtornos alimentares, e transformar nossa compreensão sobre como medicina, mente e memória se interconectam de formas surpreendentes.ReferênciasNesvig K. My GLP-1 Medication Changed the Way Perfume Smells to Me. Allure. 2025 Apr 17.Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Chiesa-Estomba CM, Salzano G, et al. Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study. J Laryngol Otol. 2020;1-7. doi: 10.1017/S0022215120001826.Huang KP, Acosta AA, Ghidewon MY, McKnight AD, Almeida MS, Nyema NT, et al. Dissociable hindbrain GLP1R circuits for satiety and aversion. Nature. 2024 Aug;632(8025):585-593. doi: 10.1038/s41586-024-07685-6.Han YE, Kang CW, Oh JH, Park SH, Ku CR, Cho YH, et al. Olfactory Receptor OR51E1 Mediates GLP-1 Secretion in Human and Rodent Enteroendocrine L Cells. J Endocr Soc. 2018 Nov;2(11):1251-1258. doi: 10.1210/js.2018-00165.Matsunami Lab. Duke University Department of Neurobiology. Disponível em: https://www.neuro.duke.edu/research/faculty-labs/matsunami-labKhan R, Doty RL. GLP-1 receptor agonists significantly impair taste function. Physiol Behav. 2024. doi: 10.1016/j.physbeh.2024.114XXX. [Artigo no prelo - ScienceDirect]Fournel A, Marlin A, Abot A, Pasquio C, Cirillo C, Cansell C, et al. The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice. Mol Metab. 2023 Jun;72:101717. doi: 10.1016/j.molmet.2023.101717.Ozempic users report surprising cravings for certain smells: Here's what to know. Fox News Health. 2025 Jun 5.Jensterle Sever M, et al. Semaglutide improves sense of taste in women with obesity. Apresentado em: ENDO 2024, Endocrine Society Annual Meeting; 2024 Jun 1; Boston, MA.Ozempic Breath: Can Weight Loss Drugs Cause Halitosis? Healthline. 2024 May 2.
In this encore episode, we detail the cellular make-up of the gastric lining, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential pathophysiological consequences of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on the influence of the oral microbiome and oral dysbiosis.Topics: 1. Introduction- Highlighting the stomach and hypochlorhydria / low stomach acid, as well as microbial balance, dysbiosis, and overgrowth.- Discussion of intestinal microbiome and oral microbiome. 2. Gastric Anatomy and Mucosal Layers- The stomach: cardia, fundus, body, pylorus.- The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae.- The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells.- Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more. 3. Mucous Cells - The surface epithelium and gastric pits.- Secretion of thick, viscous mucus.- Protecting the epithelium.- The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage. 4. Parietal Cells and Gastric Acid Secretion- Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food.- Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum. 5. Chief Cells and Pepsinogen- Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin.- Pepsin and protein digestion.- Release of gastric lipase. 6. Hydrochloric Acid: Digestive and Protective Roles- Immune defense.- Pepsinogen activation.- Adequate gastric acidity essential for properly acidified chyme.- Priming release of bile and pancreatic enzymes. 7. The Small Intestine, Stomach, and Microbial Regulation- The pyloric sphincter.- The stomach supports minimal microbial diversity.- Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine. 8. Hypochlorhydria, Low Stomach Acid- Hypochlorhydria can compromise one of the body's defense mechanisms.- Colonization of the small intestine.- Insufficient pepsinogen activation and possible protein digestion impairment.- Suboptimal chyme formation and downstream digestive capacity.- Possible symptoms of hypochlorhydria.- Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium.- H. pylori infection, autoimmunity, aging. 9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis- Oral and environmental microbes.- Altered gastric pH, bile, digestive enzymes, and more.- The oral cavity as the gateway to the GI tract.- Oral microbial species.- Oral hygiene and oral microbiome health. 10. Conclusion- Root-cause approach.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
BUFFALO, NY — June 17, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 1, 2025, titled “Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets.” In this study, scientists from Fukushima Medical University School of Medicine investigated how the hormone oxytocin (Oxt) influences insulin levels by acting on specific cells in the pancreas. The team led by first author Kasumi Hattori and corresponding authors Kenju Shimomura and Yuko Maejima discovered that oxytocin may indirectly increase insulin secretion by triggering another hormone, GLP-1, from within the pancreas. This finding could lead to new strategies for improving blood sugar control in people with diabetes. Oxytocin is commonly known for its roles in childbirth and social bonding, but scientists have also been exploring its effects on metabolism. While previous studies offered mixed results about whether oxytocin raises or lowers blood sugar, this research brings new clarity. The study focused on oxytocin's impact on insulin and a hormone called GLP-1, which helps regulate insulin production. Researchers tested this by using mice with and without oxytocin receptors and found that oxytocin's ability to raise insulin levels depended on the presence of these receptors and high blood sugar conditions. Researchers found that oxytocin stimulates the release of “intra-islet GLP-1,” a form of GLP-1 produced inside the pancreas rather than the intestine. In the pancreas, insulin is produced by beta cells, while alpha cells produce glucagon, a hormone that raises blood sugar. But recent research, including this study, has shown that alpha cells can also release GLP-1, which in turn helps beta cells secrete insulin. Oxytocin appears to increase this internal GLP-1 release, especially when blood sugar levels are high, thereby leading to insulin release in a natural and targeted way. In this study researchers were also able to detect the difference between oxytocin's effect on blood sugar and its effect on insulin. They observed that right after oxytocin was given, blood sugar levels rose in all mice—even in those that lacked oxytocin receptors. However, only the mice with working oxytocin receptors showed a later increase in insulin. This suggests that oxytocin may trigger insulin production through a separate, receptor-dependent pathway involving the hormone GLP-1. "WT mice showed a significant increase in insulin levels at 15-min, while OxtR KO mice did not." This indirect action—oxytocin triggering alpha cells to release GLP-1, which then acts on beta cells—may represent a novel mechanism for controlling insulin release. It also explains why oxytocin does not increase insulin in low-glucose conditions, making it a potentially safer option for regulating blood sugar. As treatments for type 2 diabetes increasingly focus on GLP-1–based drugs, this study opens the door to using oxytocin or similar compounds to naturally enhance the body's own insulin-producing system. With further research, this mechanism could help develop new therapies that better mimic the body's natural glucose control, particularly beneficial for older adults with diabetes. DOI - https://doi.org/10.18632/aging.206244 Corresponding authors - Kenju Shimomura - shimomur@fmu.ac.jp, and Yuko Maejima - maejimay@fmu.ac.jp Video short - https://www.youtube.com/watch?v=C0K6uDX4z8U To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
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In this episode, we detail the cellular make-up of the gastric lining, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential pathophysiological consequences of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on the influence of the oral microbiome and oral dysbiosis.Topics: 1. Introduction- Highlighting the stomach and hypochlorhydria / low stomach acid, as well as microbial balance, dysbiosis, and overgrowth.- Discussion of intestinal microbiome and oral microbiome. 2. Gastric Anatomy and Mucosal Layers- The stomach: cardia, fundus, body, pylorus.- The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae.- The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells.- Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more. 3. Mucous Cells - The surface epithelium and gastric pits.- Secretion of thick, viscous mucus.- Protecting the epithelium.- The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage. 4. Parietal Cells and Gastric Acid Secretion- Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food.- Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum. 5. Chief Cells and Pepsinogen- Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin.- Pepsin and protein digestion.- Release of gastric lipase. 6. Hydrochloric Acid: Digestive and Protective Roles- Immune defense.- Pepsinogen activation.- Adequate gastric acidity essential for properly acidified chyme.- Priming release of bile and pancreatic enzymes. 7. The Small Intestine, Stomach, and Microbial Regulation- The pyloric sphincter.- The stomach supports minimal microbial diversity.- Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine. 8. Hypochlorhydria, Low Stomach Acid- Hypochlorhydria can compromise one of the body's defense mechanisms.- Colonization of the small intestine.- Insufficient pepsinogen activation and possible protein digestion impairment.- Suboptimal chyme formation and downstream digestive capacity.- Possible symptoms of hypochlorhydria.- Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium.- H. pylori infection, autoimmunity, aging. 9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis- Oral and environmental microbes.- Altered gastric pH, bile, digestive enzymes, and more.- The oral cavity as the gateway to the GI tract.- Oral microbial species.- Oral hygiene and oral microbiome health. 10. Conclusion- Root-cause approach.Thank you to our episode sponsor:1. Shop Fresh Press Farms'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Christ in you: The pathway to being born again and receiving the baptism of fire and the Holy Ghost,
In this episode, we discuss the anatomy and physiology of the stomach and its unique epithelial structure. We dive into the pathophysiological implications of conditions such as Helicobacter pylori infection and hypochlorhydria, examining how they disrupt gastric function and microbial balance. Finally, we connect these concepts to the small intestine, discussing possible downstream effects of altered gastric acid secretion, focusing on microbial colonization and contributions to broader gastrointestinal health challenges, such as small intestinal bacterial overgrowth (SIBO). Topics: 1. Introduction Highlighting the stomach and anatomy. Discussion on H. pylori. Interplay between the stomach and small intestines, focusing on microbial balance and overgrowth. 2. Anatomy of the Stomach The stomach as a hollow, muscular organ located between the esophagus and small intestine. Anatomical regions: cardia, fundus, body, and pylorus. Layers of gastric mucosa: epithelial lining, lamina propria, and thin band of smooth muscle. 3. Epithelial Lining and Specialized Cells Mucous cells: Location within the surface epithelium and gastric pits. Secretion of viscous mucus containing mucins, forming a protective barrier. Role in shielding the epithelial lining from acidic gastric juices and creating a neutral microenvironment. Parietal cells: Location in the gastric glands, predominantly in the fundus and body. Secretion of hydrochloric acid (HCl) for digestion and defense. Production of intrinsic factor and vitamin B12 absorption. Chief cells: Secretion of pepsinogen, converted to pepsin for protein digestion. Production of gastric lipase for lipid digestion. Enteroendocrine cells: Hormone secretion. Gastrin, acid secretion and gastric motility. 4. Protection and Functionality of Gastric Mucosa Physical and chemical barriers. Acidic environment maintained by parietal cells for enzymatic activity and pathogen defense. Coordination of cell functions for efficient digestion and protection. 5. Transition from Stomach to Small Intestine Anatomical junction marked by the pyloric sphincter. Balancing the acidic environment of the stomach with the intestinal conditions. Differences between stomach and intestinal epithelial barriers. 6. Microbial Communities in the Stomach and Intestines Limited microbial diversity in the stomach due to its low pH. Acid-resistant populations such as H. pylori and their impact on microbial diversity. H. pylori , chronic gastritis, ulcers, and gastric lining atrophy. 7. H. Pylori Infection and Symptoms Symptoms, manifestations. 8. Low Stomach Acid (Hypochlorhydria) The role of stress, aging, and infections. Downstream effects, particularly in the development of small intestinal bacterial overgrowth (SIBO). 9. Small Intestinal Bacterial Overgrowth (SIBO) Definition and microbial population thresholds. Protective mechanisms regulating bacterial density in the small intestine. Role of low stomach acid in bacterial colonization and overgrowth. Consequences of SIBO, including symptoms and metabolic activity of overgrown bacteria. 10. Conclusion Root cause analysis. Thank you to our episode sponsor: 1. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
Real Life Devon shared highlights from their recent trip to Oregon, where they visited the coast, skipped skiing, and explored a lighthouse. The visit to Tillamook stood out, especially encountering a hilariously judgy giant cow head. Check out Tillamook here. Steven went on a major upgrade spree, adding a new desk chair, soundboard, and computer to their setup. They also delved into tabletop RPGs, including Perils & Princesses (official site), The Princess in Black (learn more), and Slugblaster, with its iconic quantum centipede kickflips. Ben talked about navigating a family challenge with their kid's walking pneumonia, which led to a movie marathon featuring The Martian and Sandlot. They're also looking forward to the upcoming adaptation of Project Hail Mary (movie details). On the gaming side, they played Void Crew. The team also reflected on the Lower Decks season finale, discussing intentionality in media consumption, and debated the myth of multitasking. More about Lower Decks here. Future or Now Ben reviewed the film Hidden Figures, celebrating the incredible achievements of NASA's “human computers” while highlighting anachronisms like gum-chewing in the 1960s. Read more about the film. Devon recapped the year's biggest science stories, from a total solar eclipse to Europa mission updates and record-breaking heat. Other highlights included mapping the fruit fly brain, Icelandic eruptions, and bird flu concerns. Full list of 2024's top science stories. Steven explored a groundbreaking AI-based therapeutic platform that mimics virus structures to develop innovative treatments. Learn more here. Book Club This week, the team discussed Ray Bradbury's A Sound of Thunder, diving into its themes of time travel, the butterfly effect, and unintended consequences. Read the story here. Next week, they'll tackle Arthur C. Clarke's The Nine Billion Names of God, a fascinating tale blending religion and technology. The story follows two programmers hired by Buddhist monks to list all possible names of God—a task that might just end the universe. Read it here.
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In this episode, we explore the critical role of Secretory IgA (sIgA) in maintaining intestinal health. We discuss how sIgA acts as a frontline immune defense, preventing pathogens from adhering to the gut epithelium and aiding in controlling microbial populations. Additionally, we dive into the implications of low and high sIgA levels - as indicated in a stool test, how sIgA levels relate to dysbiosis and Candida overgrowth, addressing underlying root causes, and tools for supporting healthy sIgA levels. Topics: 1. Introduction to Secretory IgA and its Functions - Overview of sIgA's role in mucosal immunity - Importance of sIgA in maintaining the gut's lining integrity - How sIgA regulates pathogenic microbes in the gut 2. Structure of the Gut Lining and Mucosal Layers - The intestinal lumen and the protective mucus layer - Layers of the intestinal wall: mucosa, submucosa, muscularis, and serosa - The epithelium within the mucosa: epithelial cells including goblet cells 3. The Mucus Layer and Its Protective Function - Composition of the mucus layer: mucins and other components - How the mucus acts as both a physical and biochemical barrier - Differences between the mucus layer in the small and large intestines 4. Secretory IgA: Location and Role in the Gut - Where sIgA is found in the mucus layer - Differences in sIgA concentration in the small vs. large intestine - Interaction between sIgA and mucins to trap pathogens 5. Production and Secretion of Secretory IgA - Plasma cells in the lamina propria and their role in sIgA production - Transport of sIgA across the gut epithelium via the polymeric immunoglobulin receptor (pIgR) - Secretory component (SC) and its role in protecting sIgA from degradation 6. Immune Functions of sIgA in the Gut - Binding and neutralizing pathogens - The process of immune exclusion - The role of sIgA in preventing pathogen adherence to epithelial cells 7. Low and High sIgA Levels and Gut Conditions - What low and high sIgA levels can indicate in a stool test - Gut conditions associated with abnormal sIgA levels (e.g., dysbiosis, Candida overgrowth, infections) - The impact of chronic stress and prolonged infections on sIgA levels 8. Root Causes for Low sIgA Levels - Addressing root causes and underlying infections - Lifestyle factors that support healthy sIgA levels - Nutrients such as Vitamin A and Zinc for supporting sIgA production 9. Probiotics & More to Support sIgA - Probiotics, prebiotics, and phages that enhance sIgA production - Individual gut health needs Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out the TruAge Biological Age Test from TruMe Labs. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
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The encounter with the Adolescent Mutated Warrior Tortles goes a lot more diplomatically than intended, but can our heroes leave the sewer without taking a dip in the tantilizing ooze pool? Dicey Bastards is a hilarious actual play comedy adventure where comedy writers go head-to-head in D&D 5e. Ridiculous characters battle their ridiculous destiny in a quest for glory and wonder!Featuring MK Gibson, Drew Hayes, Rick Gualtieri, Robert Bevan, EM Kaplan and Steve Wetherell. Check us out at www.authorsanddragons.com or follow us on https://www.facebook.com/groups/authorsanddragons. You can even support us on www.patreon.com/authorsanddragons and get access to our Discord features and bonus content.
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Coming up on todays Episode:…Two kisses greeting, Becky's fresh lips, snail serum, Salmon sperm, Lorraine & Louise, the limping manThanks to our wonderful sponsors:Balkan HolidaysEast Midlands AirportGuys, please give us a like and a follow! We would really appreciate it!Get in touch with you amazing stories; thelauraandbeckyshow@gmail.com@thelauraandbeckyshow on Insta We love you! Please become a member here https://plus.acast.com/s/the-laura-becky-show. Hosted on Acast. See acast.com/privacy for more information.
A ton of new stuff! An outstanding new release sent in by Vacaville CA's System 86! Find them on Instagram @system86_band. Also, a sneak peek from our friends at Sistema Mortal Tapes Italy and their two pre-orders. Go grab the physicals before they are sold out!461 Playlist:System punk...Sistema Mortal Tapes Italy SPEZZA LE CATENE (break the chains) 1:04 Vida Muerta Il sole che trema (the sun that trembles) IN THE MIRROR 1:01 TERMINATION Omega UK Modern-Day Slavery 1:23 Active Minds Split EP w/ Sanctus Iuda Vacaville Street Dogs 2:07 System 86 Not The Same WESTERN RELAXATION CS (bkgrd) 5:37 DEMOCRACY Western Relaxation CS Loopy Scoop Tapes IN RULES 2:20 NIGHTMAN S/T Dirt Bag Distro KC WE DON'T SELL CRACK! 1:16 RATS ASS KILL YOUR ABUSER EP Upset Condition IN Song 9 1:05 Useless Info 2nd Middleman Recs IN Bastard Son 0:44 Violent Abuse Demo MMXXIV F. Valley liquid heroin 0:33 PUNCH A HOLE IN A WALL SHOOT SOME TOP Sac Skull Crusher 1:13 Secretion Fetid Odors from the Drainage Pipe Oakland FIST 1:30 COCKRING PROMO 2024 DNA 1:14 ThrashTapes MARVELOUS - ''BARENO!!!" EP (THRASH#14) Age of Comments 0:46 Shut the Fuck Up - The Curse of Thinking You're Smart Lost Cause 1:17 Brothers Grim Punk - Long Live Punk Junk (bkgrd) 3:19 ZIG-ZAG ZIG-ZAG Stagnant Dream 2:00 HEAVEN 4-TRACK EP_Iron Lung Recs Here Comes The Hate 0:28 Brain Tourniquet Brain Tourniquet_Deliriant Nerve Split Iron Lung Recs Spent Casing 0:46 Deliriant Nerve Brain Tourniquet_Deliriant Nerve split Iron Lung Recs Brainrotter Recs UK Hard Work 1:17 Inflicter Blood Feud / Inflicter Belgium Verk 1:01 Röt Stewart 3 Tattoos & A Road Tax Bill Ambush Recs Limp Bizkit Break Stuff Live At Woodstock 99 1080P HD 1:20 Hockey Smile Daddies Of Powerviolence Bad Habits 1:25 Destroy L.A. Vandalize ep 2007 Cleveland NO END IN SIGHT 0:50 Yambag Mindfuck Ultra Netherlands Kriegsverbrecher 1:06 KRÄNKER KRÄNKER Demo I NC Nuclear Cage 2:18 POLLUTE. POLLUTE. EP. Saskatoon Napalm Attack 1:14 Krash Nothing is Sacred Paintings (bkgrd) 4:01 Gorilla x Monsoon Gorilla x Monsoon BC Right To Your Door 1:20 Bootlicker 1000 Yd. Stare Seattle Waste Away 1:28 Bad Image II Brainrotter Recs Scorched Earth Policy 0:52 Total Con Eleven-Song Cassette Earth Girl Tapes MS LOST IN MY HAZE 1:14 SHITTY LIFE SPLIT Spain Futbola nazka ematen dit (I hate futbol) 1:23 Infekzioa - "Ezin Da Alde Egin Sufrimenduaren Zulotik" (you can't get out of the pit of suffering) EP 7" (2014) The Subwys - Brutallies 1:18 ssslashing SHORT LIFE VOLUME I Croatia Victims Of Progress 1:08 Nuclear Altar Wasteland Filth Boston Drugs 1:49 SCÜMBARI S/T Disease's Last Stand 1:17 Nobodys Generation XXX Humoldt Co CA King of the Road 1:49 The Dayjobs Soundcloud Single Radioactive (bkgrd) 5:28 SSYNTAXX A•N•G•E•R Stop 1:40 13 Self Titled Other ways to hear BGP:Archive.org#461 on ArchiveApple PodcastsYouTube PodcastsPunk Rock Demonstration - Wednesdays 7 p.m. PSTRipper Radio - Fridays & Saturdays 7 p.m. PSTContact BGP:brothersgrimpunk@gmail.com@Punkbot138 on Instagram@BrosGrimPunk on XMore Music:Bandcamp - Follow us and download our albums: Brothers Grim Punk, Fight Music, and more!YouTube - tons of our punk playlists, from Anarchy to Zombies!
Jackie is back from Paris Fashion Week with the raw retinas to prove it. After contracting conjunctivitis, she recaps her medical trauma whilst abroad. She also discusses the Oscars and breaks down her best dressed. Apologies to Vanessa Hudgens. Thanks for supporting my sponsors! Happy Mammoth: Use code JACKIE at checkout to get 15% off on your first order at www.happymammoth.com Sono Bello: Schedule your FREE consultation today at www.sonobello.com/BIBLE This episode is brought to you by BetterHelp: Visit www.betterhelp.com/BITCHBIBLE today to get 10% off your first month
Kelly-Marie Kerr's books explore parallels between Scripture and science, about topics such as the Sacred Secretion, 3-fold enlightenment, Great Regeneration, Kundalini Energy and other alchemical mysteries such as the "monthly seed." A diligent researcher, practitioner, and author in alchemy, spirituality, yoga, and other esoteric subjects, Kelly-Marie always takes care to corroborate her findings with peer-reviewed science and the work of other credible published authors. Topics: - The Sacred Secretion (Great Regeneration, Threefold Enlightenment). - Bible alchemy - The biochemistry of awakening - Kundalini science and experiences -The Seed of Life Kelly-Marie Kerr's website: https://www.seekvision.co.uk/ Click here to learn about Embodied Ascension Training and Conscious Life Creation with Waxela Sananda: https://waxelasananda.com/ascension-training/ Join Waxela's email list for Ascension conversations, event invites, and more: https://waxelasananda.com/join/ https://www.instagram.com/pinealactivationlight/
References Biomedicines 2023, 11(7), 1804 BMC Biology. 2011. 9:85 Cancer Res. 2011 Jan 15;71(2):293-7. FEBS Lett.2019.593.17:2428-2451 Verdi, G. 1841. Nabucco Overture https://youtu.be/OseGETWEnCo?si=LhiIQV-N0-_Z_s-s Lennon&McCartney. 1966 "For No One". Beatles: Revolver. https://youtu.be/sep5E3ssXLQ?si=WLtMrP-Xq279qZXl --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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In this study, researchers found that the genetic material from the virus and possibly other parts activate TLR3 receptors. These in turn cause the cells to release IFN1. IFN1 works on the intestinal cells via STAT1 pathway to down-regulate ACE2 receptors and B0AT1 channels. The result is reduced absorption of tryptophan leading to reduced serotonin production in the body. They also found that IFN1 activates platelets leading to micro thrombi and further reduction of serotonin as platelets are a huge reservoir of serotonin. Researchers also found that MAO activity was increased. Vagal activity was reduced leading to the hippocampal reduction in function as well. The researchers suggest using tryptophan precursor supplement (5HTP - 5 hydroxytryptophan) and SSRI medications to rescue serotonin levels in long COVID patients. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL List (Nov. 24 2023) Serotonin reduction in post-acute sequelae of viral infection: Cellhttps://www.cell.com/cell/fulltext/S0092-8674(23)01034-6#gr2 Serotonin in Platelets - ScienceDirecthttps://www.sciencedirect.com/science/article/abs/pii/B978012800050200005X IJMS | Free Full-Text | The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptaminehttps://www.mdpi.com/1422-0067/22/15/7931 ijms-22-07931-g001.png (3550×2309)https://www.mdpi.com/ijms/ijms-22-07931/article_deploy/html/images/ijms-22-07931-g001.png Uptake and release of serotonin by blood platelets. Serotonin is taken... | Download Scientific Diagramhttps://www.researchgate.net/figure/Uptake-and-release-of-serotonin-by-blood-platelets-Serotonin-is-taken-up-from-the_fig2_367097021 Indoleamine 2,3-dioxygenase - Wikipediahttps://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase#:~:text=Indoleamine%2Dpyrrole%202%2C3%2D,female%20genital%20tract%20or%20placenta. Frontiers | Kynurenine Pathway Metabolites as Biomarkers for Amyotrophic Lateral Sclerosishttps://www.frontiersin.org/articles/10.3389/fnins.2019.01013/full Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377577/#:~:text=Toll%2Dlike%20receptor%203%20(TLR3)%20is%20a%20member%20of,establishing%20an%20antiviral%20host%20response. Mechanisms of type-I- and type-II-interferon-mediated signalling | Nature Reviews Immunologyhttps://www.nature.com/articles/nri1604 Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Kirk takes us on a journey to learn about where the smell of Musk comes from and along the way we find out about a problem with the synthetic versions that took our nostrils by storm starting in the 1990s. Rachel then tells the amazing story about how the physical structure of dragonfly wings can destroy bacteria just by coming into contact with it. Support us: patreon.com/strangebynature Email us: contact@strangebynaturepodcast.com Visit us at: strangebynaturepodcast.com
In this episode, we review the high-yield topic of Pancreatic Secretion from the Gastrointestinal section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
24 hours until Jackson & KG leave for Sin City. Rick and KG's chances of getting home in Vegas. Iggy would be at 75%. If Rick gets a couple of boat drinks in him. There's another strong stream in the restroom this morning. The Dirty. Tucker checking in this morning with tales of lesbianism in Williamsport. Secretion. Ambassador of hot lezzys. Pool parties in Vegas. Jackson might get a temporary tattoo before going. Husky gals in the corner pleasuring themselves. Those pesky army bases. Going to the zoo with strippers. Hookers are people too. Iggy with a nice little stripper story and the texts aren't great. Jackson is dedicating this show to Heather Graham. Larry Nickel with the WWE recap. Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
24 hours until Jackson & KG leave for Sin City. Rick and KG's chances of getting home in Vegas. Iggy would be at 75%. If Rick gets a couple of boat drinks in him. There's another strong stream in the restroom this morning. The Dirty. Tucker checking in this morning with tales of lesbianism in Williamsport. Secretion. Ambassador of hot lezzys. Pool parties in Vegas. Jackson might get a temporary tattoo before going. Husky gals in the corner pleasuring themselves. Those pesky army bases. Going to the zoo with strippers. Hookers are people too. Iggy with a nice little stripper story and the texts aren't great. Jackson is dedicating this show to Heather Graham. Larry Nickel with the WWE recap. Learn more about your ad choices. Visit megaphone.fm/adchoices
Support this podcast at — https://redcircle.com/hypnosis-and-relaxation-sound-therapy9715/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Support this podcast at — https://redcircle.com/hypnosis-and-relaxation-sound-therapy9715/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Support this podcast at — https://redcircle.com/hypnosis-and-relaxation-sound-therapy9715/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
In this episode, we review the high-yield topic of Bile Secretion from the Gastrointestinal section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
References Cells. 2019 Mar; 8(3): 227 Chest. 2016 Jul; 150(1): 91–101 JCI Insight. 2016 Nov 17; 1(19): e87748. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
References JCI Insight. 2016 Nov 17; 1(19): e87748. Graduate Biochemistry lecture archives-Guerra Nutrition. 2020 Oct;78:110935. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
References Dr. Guerra's lipid lectures J Diabetes Investig. 2019 Nov; 10(6): 1430–1437. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
Blog summary of an editorial perspective published in Oncotarget on entitled, “Leakage? or Secretion? unconventional protein secretion in cancer.” ________________________________________ Conventional protein secretion is fairly well understood in this day and age. Proteins that are secreted through the classical, secretory vesicle-related pathway contain a signal peptide that guides them to the endoplasmic reticulum (ER), where they are further processed and transported to the Golgi apparatus. From there, the Golgi apparatus modifies, sorts and packages proteins for transport to their final destinations within the cell or for secretion outside of the cell. However, in recent years, it has become clear that not all secreted proteins follow this conventional pathway. Instead, some proteins are secreted through unconventional pathways that do not require a signal peptide or the involvement of the ER or Golgi apparatus. In a recent editorial perspective published in Oncotarget on February 20, 2023, “Leakage? or Secretion? unconventional protein secretion in cancer,” researchers Kohji Yamada and Kiyotsugu Yoshida from The Jikei University School of Medicine in Tokyo, Japan, discuss unconventional protein secretion (UPS) and its significance in the progression of cancer. “In contrast, the secretion of proteins that do not code for signal peptides may occur via two or more mechanisms, often collectively referred to as unconventional protein secretion (UPS).” Full blog - https://www.oncotarget.org/2023/03/16/unconventional-protein-secretion-ups-in-cancer/ DOI - https://doi.org/10.18632/oncotarget.28368 (PDF Download) Correspondence to - Kohji Yamada - kyamada@jikei.ac.jp, and Kiyotsugu Yoshida - kyoshida@jikei.ac.jp Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28368 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - unconventional protein secretion, cancer, endoplasmic reticulum About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
In this episode, we review the high-yield topic of Gastric Secretion from the Gastrointestinal section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message
Episode 22: Hormones, Practice Questions, and Treats of the Past This week, Zak celebrates a new job as a campus dietitian, discusses a treat from his old job that will be missed, and reviews the major hormones to know for the RD Exam with some practice questions. Listen in! Which of the following hormones an increase in reabsorption of water and sodium: A. Vitamin D B. Aldosterone C. Ghrelin D. Somatostatin 2. Secretion of hydrochloric acid from stomach parietal cells is triggered from: A,. Lack of food B. Carbohydrates C. Gastrin hormone D. Water 3. Low levels of _______ would be present after a Thanksgiving meal, low levels of ______ would be present in a patient with low amounts of body fat. A. Ghrelin, Leptin B. Leptin, Ghrelin C. CCK, Leptin D. Glucagon, Ghrelin DM for your RD Exam tutoring needs! Instagram: @zak_snacks Youtube: Zak Kaesberg MS, RDN
Deanne Deaville joins us again here at the Rebel Scientist pod. She is a best-selling author, healthy lifestyle coach and workshop facilitator with a formal background in nutrition. Before embarking in health and wellbeing, Deanne worked 20+ years in Silicon Valley in various roles from marketing communications manager to launching and heading up a capital equipment company in the semiconductor test industry. She shares more incredible stories about her experience with Kambô, Amazonian giant Maki frog secretions and much more. Let's just say she hit WARRIOR MODE!DISCLAIMER: This podcast is for educational and informational purposes only and is solely intended as a self-help tool for your own use.
Welcome to the '5th Thing' with Amy & Kat!! They kicked things off with a Dr. Seuss quote: "Fun is good!” and then got into some more concrete conversation cards and answered questions like: What were you known for in High School? What is an impactful book you've read and why? In an ideal world, what is one habit you'd like to do everyday, and why? What is a topic that gets you fired up?" That last question transpired into people that get mad at Amy for supporting Haiti instead of America (that really gets her fired up!!!) More questions: What product is currently your favorite? Amy shared about some snail secretion masks she's been using lately that are super moisturizing! Other things discussed: Kat has a new boyfriend, pizza toast, shopping at Aritzia (where they don't have mirrors in the dressing rooms!), and listener emails (one about nipple tattooing and another about nutrition/infertility/adoption). They closed out with another conversation card question: Have you ever accidentally shoplifted??? Thank you licensed therapist, Kat Defatta, for joining us with her wisdom. You can find her on Instagram: @Kat.Defatta + @YouNeedTherapyPodcast. ShopEspwa.com for all items that support Haiti! Specifically @medishare4haiti right now (for their maternity centers…in honor of Mother's Day) Best places to find more about Amy: RadioAmy.com + @RadioAmy Please send emails for the 5th thing to 4ThingsWithAmyBrown@gmail.com Learn more about your ad-choices at https://www.iheartpodcastnetwork.com
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