POPULARITY
16 episodes with Glucagon
11 episodes with Glucagon
17 episodes with Glucagon
10 episodes with Glucagon
6 episodes with Glucagon
4 episodes with Glucagon
4 episodes with Glucagon
2 episodes with Glucagon
3 episodes with Glucagon
Send us a textToday we are releasing a bonus episode!This is my recent appearance on the Low Carb and Fasting YouTube Channel hoisted by Nayiri Mississian! We were fortunate enough to host Nayiri on our podcast on episode 437 and episode 737 of Boundless Body Radio!As always, it was a fun chat, and I'm always so grateful to be a guest on someone else's show!Nayiri Mississian is an independent nutrition researcher, who has no associations with the food industry, pharmaceutical industry or any politically powered nutrition organizations. Nayiri shares her scientific information with the followers in her members-only exclusive Facebook groups, which promote the low carbohydrate/low insulin lifestyle as supported by scientific evidence. The low carb and fasting group members have free access to summarized information posts, recipes, tips, and weekly live videos. Nayiri is the host of the fantastic Low Carb and Fasting Podcast!Find Nayiri at-https://lowcarbandfasting.com/TW- @NTSTranslationFB- @LOW CARB & FASTINGPodcast- Low Carb and Fasting PodcastNayiri's amazing and very helpful blood glucose conversion charts!Stephen Thomas, known online as the UK Carnivore, debunks and dispels many popular myths about nutrition, fitness, and aging. In the past, while eating high-carbohydrate, low-fat diet, Stephen was a semi-professional soccer player, won a singles tennis tournament, and had run some middle-distance races, but his health was poor, as he had experienced frequent colds, and struggled with several other health issues.Find Stephen at-https://www.theukcarnivore.com/IG- @theukcarnivoreYT- @Coach Stephen BSc HonsPodcast- The UK Carnivore ExperienceFind Boundless Body at- myboundlessbody.com Book a session with us here!
Can a nitro slurry help with food bolus impaction? Glucagon and effervescent beverages have limited evidence for benefit. Can an old drug used in a new way help these patients?
In this EASL DeepDive held on 30 October 2024, Henning Grønbæk, Cyrielle Caussy, Mazen Noureddin and Frank Tacke provide an understanding of the role of glucagon and glucagon-receptors in physiology and in MASH patients. Additionally, they review key clinical trials and evaluate the integration of GLP-1 receptor agonists into current EASL-EASD-EASO clinical guidelines for practical patient management.Learning objectives:Understand the role of glucagon and glucagon-receptor in normal physiology and disease.Understand the rationale of a combined dual GLP-1/GCG RA and its potential benefit compared to a GLP-1RA alone and thus gain insights into the mechanisms through which GLP-1 receptor agonists and GLP-1/GCG might affect liver pathology and metabolic regulation.Discuss and review key clinical trials and ongoing development programs.Evaluate how GLP-1RA can be integrated into current EASL-EASD-EASO CPGs, with a focus on practical applications and patient management strategies, giving potential guidance for future applications.This EASL DeepDive webinar is supported by Boehringer Ingelheim. Boehringer Ingelheim has had no input into the content of this EASL DeepDive.Click here to see all EASL Video Podcasts on Apple Podcasts.
Ozempic and other GLP-1 drugs have exploded in popularity largely due to their effectiveness in treating type-2 diabetes and, perhaps more significantly, their weight-loss effects. But what do we know about these drugs and how they work? We're joined by Dr. Daniel J. Drucker, Dr. Sanjeev Sockalingam, and registered dietician Nishta Saxena.See omnystudio.com/listener for privacy information.
In this Huberman Lab Essentials episode, I explain how hormones regulate hunger, appetite and feelings of satiety (fullness), along with strategies to help control appetite. I describe how the body senses nutrient levels and how the brain processes these signals to stimulate hunger or suppress appetite. I also discuss how certain foods can help curb hunger, while processed foods and emulsifiers can interfere with satiety signals, leading to overeating. Additionally, I cover how lifestyle factors such as exercise and meal timing regulate blood glucose levels, which in turn impact hunger and appetite. Huberman Lab Essentials episodes are approximately 30 minutes long and focus on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, while our full-length episodes will continue to be released every Monday. This Huberman Lab Essentials is from the full-length Huberman Lab episode, “How Our Hormones Control Our Hunger, Eating & Satiety.” Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David Protein: https://davidprotein.com/huberman Mateina: https://drinkmateina.com/huberman LMNT: https://drinklmnt.com/huberman For all Huberman Lab sponsors, visit hubermanlab.com/sponsors. Timestamps 00:00:00 Huberman Lab Essentials; Hunger & Appetite 00:00:56 Hunger, Hypothalamus, Cortex & Mouth 00:04:46 Sponsor: David Protein 00:06:02 Melanocyte-Stimulating Hormone, AgRP Neurons, Ghrelin, Tool: Regular Meal Timing 00:10:13 Cholecystokinin (CCK), Tool: Omega-3s, Amino Acids & Blunting Appetite 00:13:26 Sponsor: AG1 00:14:30 Highly-Processed Foods, Emulsifiers, Tool: Whole Foods & Satiety Signals 00:19:10 Insulin, Glucose, Type 1 & 2 Diabetes 00:22:16 Sponsor: Mateina 00:23:41 Insulin & Glucagon, Tools: Food Order, Movement & Blood Glucose 00:27:26 Tool: Exercise & Stable Blood Sugar 00:29:38 Metformin, Ketogenic Diet, Blood Glucose 00:31:59 Sponsor: LMNT 00:33:16 Diabetes, Urine & Blood Sugar 00:35:40 Caffeine, Tool: Yerba Mate, Glucagon-Like Peptide -1 (GLP-1), Appetite 00:38:49 Recap & Key Takeaways Disclaimer & Disclosures
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of drugs initially developed to treat type 2 diabetes and are now becoming more widely used for obesity. They work by mimicking the actions of the GLP-1 hormone, which is released by the gut after eating. GPs will be used to prescribing them for type 2 diabetes, but less so for obesity. In this podcast, Dr Thomas Round discusses the evolving role of GLP1-RA in obesity, the benefits and potential side effects, the role of the GP, and the latest NICE guidance in this area with Dr Stephanie DiGiorgio, an urgent care GP with a specialist interest in obesity.
How do GLP-1 receptor agonists and metformin affect glaucoma risk in patients with Type 2 diabetes? Join Dr. Ike Ahmed and Jawad Muayad as they discuss the data on diabetes treatments and glaucoma risk with Dr. Emily Schehlein. From their Ophthalmology article, “Comparative Effects of Glucagon-like Peptide 1 Receptor Agonists and Metformin on Glaucoma Risk in Patients with Type 2 Diabetes.” Comparative Effects of Glucagon-like Peptide 1 Receptor Agonists and Metformin on Glaucoma Risk in Patients with Type 2 Diabetes. Muayad, Jawad et al. Ophthalmology. In press.
Sarah shares her low BG stories. JUICE CRUISE 2025 Learn about the Medtronic Champions Try delicious AG1 - Drink AG1.com/Juicebox I Have Vision Use code JUICEBOX to save 40% at Cozy Earth CONTOUR NextGen smart meter and CONTOUR DIABETES app Learn about the Dexcom G6 and G7 CGM Go tubeless with Omnipod 5 or Omnipod DASH * Get your supplies from US MED or call 888-721-1514 Learn about Touched By Type 1 Take the T1DExchange survey *The Pod has an IP28 rating for up to 25 feet for 60 minutes. The Omnipod 5 Controller is not waterproof. How to listen, disclaimer and more Apple Podcasts> Subscribe to the podcast today! The podcast is available on Spotify, Google Play, iHeartRadio, Radio Public, Amazon Music and all Android devices The Juicebox Podcast is a free show, but if you'd like to support the podcast directly, you can make a gift here or buy me a coffee. Thank you! Disclaimer - Nothing you hear on the Juicebox Podcast or read on Arden's Day is intended as medical advice. You should always consult a physician before making changes to your health plan. If the podcast has helped you to live better with type 1 please tell someone else how to find the show and consider leaving a rating and review on Apple Podcasts. Thank you! The Juicebox Podcast is not a charitable organization.
Laura saved a man with her glucagon! JUICE CRUISE 2025 Eat Hungryroot Screen It Like You Mean It Eversense CGM Learn about the Medtronic Champions This BetterHelp link saves 10% on your first month of therapy Try delicious AG1 - Drink AG1.com/Juicebox I Have Vision Use code JUICEBOX to save 40% at Cozy Earth Get Gvoke HypoPen CONTOUR NextGen smart meter and CONTOUR DIABETES app Learn about the Dexcom G6 and G7 CGM Go tubeless with Omnipod 5 or Omnipod DASH * Get your supplies from US MED or call 888-721-1514 Learn about Touched By Type 1 Take the T1DExchange survey *The Pod has an IP28 rating for up to 25 feet for 60 minutes. The Omnipod 5 Controller is not waterproof. How to listen, disclaimer and more Apple Podcasts> Subscribe to the podcast today! The podcast is available on Spotify, Google Play, iHeartRadio, Radio Public, Amazon Music and all Android devices The Juicebox Podcast is a free show, but if you'd like to support the podcast directly, you can make a gift here or buy me a coffee. Thank you! Disclaimer - Nothing you hear on the Juicebox Podcast or read on Arden's Day is intended as medical advice. You should always consult a physician before making changes to your health plan. If the podcast has helped you to live better with type 1 please tell someone else how to find the show and consider leaving a rating and review on Apple Podcasts. Thank you! The Juicebox Podcast is not a charitable organization.
Send us a textNayiri Mississian is a former guest on our show! Check out her first appearance on episode 437 of Boundless Body Radio!Nayiri Mississian, MHP is an independent nutrition researcher, who has no associations with the food industry, pharmaceutical industry or any politically powered nutrition organizations. She has been involved in nutrition research since 2015. Nayiri shares her scientific information with the followers in her members-only exclusive Facebook groups, which promote the low carbohydrate/low insulin lifestyle as supported by scientific evidence.This is the only lifestyle, as shown in medical science, that prevents or reverses insulin resistance, thus dramatically reducing one's chances of developing metabolic illnesses such as type 2 diabetes, obesity, hypertension, heart disease, Alzheimer's, and even some types of cancer.The low carb and fasting group members have free access to summarized information posts, recipes, tips, and weekly live videos. Nayiri is the host of the Low Carb and Fasting channel on YouTube, which I was honored to be hosted on. She is an avid gardener in the summer when the weather cooperates!Find Nayiri at-https://lowcarbandfasting.com/YT- Low Carb and Fasting PodcastFB- @LOW CARB & FASTINGNayiri's amazing and very helpful blood glucose conversion charts!Find Boundless Body at- myboundlessbody.com Book a session with us here!
In this episode of Regaining Health & Humanity, host Dr. Scott A. Johnson and expert guest Dr. Lawry Han explore Glucagon-like peptide-1 (GLP-1) and its vital role in metabolic processes. Delve into the mechanisms behind GLP-1 dugs in managing diabetes and obesity, the potential risks, and the rise in popularity of these drugs. As demand grows, so does interest in natural alternatives. Dr. Han shares insights on promising supplements that mimic GLP-1 effects and the latest research on these revolutionary therapies, helping you make informed choices for metabolic health. --- Support this podcast: https://podcasters.spotify.com/pod/show/scott-a-johnson/support
Send us a textDr. Ryan Attar is a returning guest on our show! Be sure to check out his first appearance on episode 186 of Boundless Body Radio!Dr. Ryan Attar is an expert in managing Type 1 diabetes. Dr. Attar is a veteran of the US Army, and after serving overseas, Dr. Attar developed Type 1 diabetes, and was medically discharged from the Army after nearly 6 years of service.After the military, Dr. Attar decided to embark on a new career to aide those with diabetes and other health issues. He graduated in 2017 from the University of Bridgeport with a Doctorate in Naturopathic Medicine and a Master's in Human Nutrition.Dr. Attar has been LIVING and THRIVING with diabetes for 12 years, and helps his patients achieve better blood glucose, A1c and weight loss goals. He is very active in the TypeOneGrit online diabetes community, a group that was studied in 2018 in the journal Pediatrics. He has written several articles on the diabetes website Diabetes Daily.When not practicing medicine, Dr. Attar is an avid traveler, having been to 75 countries. Dr. Attar also enjoys fitness, weightlifting and is currently a blue belt in jiujitsu!Find Dr. Attar at-https://drattar.com/TW- @ryanattarThe Diabetes Solution documentary!Find Boundless Body at- myboundlessbody.com Book a session with us here!
Kamyar Ghabili, MD, discusses the AJR article by Nelson et al. identifying patterns of changes in CT-based body composition measures after initiation of semaglutide therapy. ARTICLE TITLE - Intrapatient Changes in CT-Based Body Composition After Initiation of Semaglutide (Glucagon-Like Peptide-1 Agonist) Therapy
This episode explores the differences between research peptides and pharmaceutical peptides, highlighting that although they are chemically identical, pharmaceutical versions tend to be more expensive due to regulatory factors. There's an emphasis on personal preference regarding trust in the FDA, with a preference for research peptides from specialized labs that focus solely on peptide production.Potential dangers of using GLP-1 drugs, such as Semaglutide, are also discussed, particularly the risk of muscle loss, which can lead to metabolic issues and weakened physical function. The importance of understanding metabolic chemistry and prioritizing fat loss over weight loss is stressed, with a recommendation to focus on macronutrients rather than calories for better health outcomes.Highlights of the Podcast00:04 - Difference Between Research and Pharmaceutical Peptides02:35 - Peptide Manufacturing Preferences04:42 - Dangers of Muscle Loss with GLP-1 Drugs (Semaglutide)09:02 - Glucagon and Diabetes Management11:47 - Calories vs. Macros
We delve into the management of esophageal foreign body obstructions, a common yet often misunderstood medical emergency. We discuss the symptoms and causes of esophageal food impactions, sometimes referred to as 'Steakhouse Syndrome,' and differentiate it from tracheal obstructions. We explore the protocols, potential treatments, and if there's any rationale behind treatments such as glucagon administration. Join us as we also share real-life scenarios to better illustrate the challenges and solutions when dealing with such medical cases. Resources and links This episode was inspired by an article on EMSAirway.com- Friday Night Lights- Shift 9 Steak Night EMScast15 - code for 15% off an awesome pair of sunglasses Help Us By Filling Out Our Audience Survey Medic Box - awesome medical gear shipped directly to your door Articles- American Society for Gastrointestinal Endoscopy- Guidelines for ingested foreign bodies Glucagon for Relief of Acute Esophageal Foreign Bodies and Food Impactions: A Systematic Review and Meta-Analysis. Efficacy of cola ingestion for oesophageal food bolus impaction: open label, multicentre, randomised controlled trial Conservative management of oesophageal soft food bolus impaction Esophageal Food Impaction: A Retrospective Chart Review Food Bolus Impaction- Question and Answer Review Guest/Cast/Crew information- Host- Ross Orpet, Will Berry Catch up with us after the show Instagram- @emscast Twitter- @ems_cast Website- www.emspodcast.com 00:00 Introduction to Esophageal Foreign Bodies 00:43 Audience Survey and Sunglasses Giveaway 01:46 Interview with Contest Winner 06:11 A Choking Incident at Mile High Stadium 09:02 Discussion on Esophageal Obstructions 11:46 Life-Saving Story at Denver International Airport 13:28 A Life-Saving Outcome 14:11 The Choking Incident at the Tavern 14:57 Assessing the Patient's Condition 19:38 Understanding Esophageal Food Impaction 21:49 Treatment Options and Challenges 29:01 The Role of Endoscopy 37:45 Managing Esophageal Impactions in the Field 39:32 Final Thoughts
Wanna chat and get more personalized support? I'm offering podcast listeners a free 20-minute Thriving Mama Check-In where we'll evaluate your physical, mental, and emotional health and provide useful resources to help you on your journey.In this episode, Stephanie discusses the impact of poor blood sugar management on hormone, mood, and weight issues in mothers and shares practical tips along with her favourite supplements to help regulate it effectively.Timestamps:5:45 Simple tips for managing blood sugar levels.15:35 How stress impacts blood sugar control.22:11 Key supplements to support healthy blood sugar.32:43 Strategies for balancing carbohydrates and protein intake.If you're interested in the recommended supplements, check out Stephanie's Dispensary on Fullscript and get 10% off your purchase!Resources Mentioned:Chris Masterjohn, PhD | YouTubeFind More From Dr. Stephanie Davis:Thrive Mama Tribe | WebsiteThrive Mama Tribe | InstagramThrive Mama Tribe | Skool
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on trends in glucagon-like peptide-1 receptor agonist social media posts using AI.
In this episode, the discussion dives into the complexities of weight loss and body composition, highlighting the importance of understanding how the body processes fat, muscle, and protein. It's explained that simply cutting calories can lead to muscle loss alongside fat, which is counterproductive since muscle is essential for maintaining metabolism. The key is focusing on losing fat while preserving muscle mass, which can be achieved through high protein intake and strategic fasting.The conversation also explores the effectiveness of keto diets in managing conditions like diabetes by forcing the body to produce its own sugar through fat and protein metabolism. The episode breaks down how insulin resistance can be addressed by limiting carbohydrate intake, allowing the body to regulate blood sugar more efficiently. This approach not only helps manage blood sugar levels but also supports fat loss without compromising muscle mass.Lastly, insights are shared on the role of GLP medications, fasting, and proper nutrition in optimizing fat-burning and muscle preservation. The potential pitfalls of muscle loss, gallstones, and other side effects from improper dieting or medications are discussed, emphasizing the importance of understanding the body's metabolic functions for sustainable health and weight management.Highlights of the Podcast00:02 - The stage to discuss the calories in/calories out model.01:24 - A calorie deficit leads to weight loss, while excess calories result in fat gain.02:41 - Personal Experience with Calorie Reduction03:57 - Observations on Individual Differences:05:10 - The role they play in fat storage and metabolic function.06:49 - Body's Energy Source - ATP vs. Calories08:15 - Breaking Down the Body's Components09:32 - Sugars vs. Fats in Fat Storage10:23 - Misconception About Calories13:57 - Role of Insulin in Absorption15:21 - High Glycemic Foods and Fat Storage:16:43 - Glucagon and Fat Burning18:17 - Why Proteins Don't Turn into Fat21:39 - The key is not to lose weight but to lose fat while preserving muscle mass22:48 - Protein's Role in Fat Loss24:06 - Keto Diet & Sugar Production25:29 - Diabetes & Insulin Resistance 27:42 - Fasting to Restart Fat-Burning 28:53 - GLP-1 Receptor Agonists 32:26 - Macro Counting vs. Hormones 36:31 - Reversing Type 2 Diabetes with Keto
Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ Danny's Website: https://t.me/dannyroddy Danny's Substack: https://dannyroddy.substack.com/ Timestamps: 0:00 – intro 0:33 – why we started this podcast 6:25 – our take on Bryan Johnson's Longevity Blueprint and problems with biohacking 12:13 – whether we should adopt any of the strategies from Bryan Johnson's Blueprint to achieve optimal health 14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity 21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet 22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits 28:00 – potential pros and cons of Bryan Johnson's Blueprint and how to measure health 32:39 – Bryan Johnson's supplement protocol 41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status 46:20 – whether body fat percentage and cholesterol levels can be too low 52:20 – what is stress? 1:03:20 – issues with hormesis and the idea that stress is beneficial 1:07:34 – whether avoiding stress is possible and how to develop resilience to stress 1:13:17 – addressing Marty Kendall's response to our take on glucagon and insulin 1:24:17 – glucagon's short-term and long-term effects on metabolic function 1:26:46 – glucagon's role in insulin resistance and type 2 diabetes 1:37:16 – metabolic dysfunction as a driver of insulin resistance 1:41:06 – whether we need to be concerned about wasting energy on hormone production 1:44:50 – whether we should always try to avoid gluconeogenesis 1:51:45 – how to use carbohydrates to stabilize your blood sugar 1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health
The 2024 Lasker–DeBakey Clinical Medical Research Award has been presented for the discovery of GLP-1 and its application to the treatment of obesity. Lasker winner Svetlana Mojsov, PhD, discusses her role in this innovative discovery and more with JAMA Senior Editor Anne Rentoumis Cappola, MD, ScM. Related Content: Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation GLP-1 for Treating Obesity—Origin, History, and Evolution AIDS in Africa—Impact of Research
In this episode, we're diving deep into GLP-1 agonists, a topic that has sparked considerable debate within the fitness and health communities. Our special guest, Anthony Castor, brings a wealth of knowledge as the first non-physician to earn a fellowship with the Seed Scientific Research and Performance Institute. Together, we'll address controversies, debunk myths, and uncover the multi-faceted benefits of GLP-1 agonists far beyond their well-known role in weight loss and diabetes management. We'll explore their neuroprotective effects, benefits in managing neurodegenerative diseases like Alzheimer's and Parkinson's, and their surprising impact on cognitive decline, addiction, and ADHD. Moreover, we'll break down complex mechanisms, historical context, and real-world applications in an easily digestible format. Stay tuned as we demystify GLP-1 agonists and reveal how they can enhance not only physical but also mental resilience. Anthony Castor, a health advocate and educator, delves into the intricate world of peptides and their multifaceted benefits. With a passion for making complex biochemical processes understandable, Anthony focuses on the potent impacts of GLP-1 (glucagon-like peptide-1), GIP (gastric inhibitory polypeptide), and myelin, among others. By demystifying how these peptides interact and function together, Anthony aims to shift public perception and drive forward significant improvements in health. Known for his use of analogies to clarify scientific concepts, Anthony is committed to educating people on the transformative potential of these sophisticated biochemical tools. Anthony's Website: https://www.castoremethod.com Instagram: https://www.instagram.com/anthonycastore/ Join Duffin Community & Education: https://www.skool.com/endless-evolution-8560/about www.chrisduffin.com
The discussion explores the intricate relationship between insulin resistance and diabetes management, challenging conventional beliefs about insulin production. It delves into the role of glucagon in weight loss and metabolism, emphasizing its critical function in enabling the body to use fat for energy. Potential dangers of overdosing on treatments like semaglutide are highlighted, including issues such as gastroparesis and gallstones.Further, the focus is on understanding the body's chemical processes rather than relying solely on calorie counting. There is advice on increasing protein and collagen intake to prevent muscle wasting and caution about using certain protein supplements. The need for more research on carbohydrate absorption while using diabetes treatments is emphasized, along with practical recommendations for managing dosage and overall health.Highlights of the Podcast00:03 - Introduction01:04 - Insulin Resistance vs. Insulin Production02:06 - Glucagon's Role in Weight Loss and Metabolism03:31 - Overdosing and Its Effects on the Body04:44 - The Impact on Insulin and Blood Sugar Levels06:05 - Liver and Gallstone Issues07:26 - Importance of Protein and Collagen08:27 - Caution Against Specific Protein Supplements09:28 - Misconceptions About Diabetes and Calorie Counting10:15 - Final Recommendations
For those of us who try to lose weight at some point in time, we know the frustration of losing weight and feeling good about that, only to see that weight return. Why does that happen? Is the process the same for adults and adolescents? Is there any way to mitigate that weight regain? Joining host Aaron Lohr is Eric Bomberg, MD, assistant professor at the Center for Pediatric Obesity Medicine at the University of Minnesota. Dr. Bomberg recently presented an abstract at ENDO 2024 titled, “Hormonal and Physiological Changes Following Short-Term Weight Loss in Adolescents With Obesity and the Role of Glucagon-Like Peptide 1 Receptor Agonist to Counteract Adaptations.” Show notes are available at https://www.endocrine.org/podcast/enp87-short-term-weight-loss-in-adolescents-with-obesity — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast
Glucagon-like peptide 1, better known as GLP-1, is at the heart of how medications like Ozempic/Wegovy (Semaglutide), Trulicity (Dulaglutide), Monjaro (Tirepatide), and others work. They are very effective at lowering blood sugar, curbing appetite, and reducing hunger, but what if you wanted to try to raise GLP1 naturally with foods or supplements? Here are the things that have been shown to do it. Keep in mind the degree to which GLP-1 increases with foods will be less than what medications can accomplish, it's also true that side effects will be minimized too. Merch Supplement Facts Mug https://joecannon.creator-spring.com/listing/supplement-facts-mug References https://youtu.be/iORj6kcw7q8 https://supplementclarity.com/best-foods-supplements-that-naturally-raise-glp-1/ Consultations https://supplementclarity.com/private-consultations/ This is the anti-wrinkle serium I mentioned. Look how inexpensive it is https://amzn.to/3LgvTBw Get My Rhabdo Book Education is the best defense against getting rhabdomyolysis. I've been teaching about rhabdo for over 10 years. If you are in the US, you can order my book directly from me. Purchase My Rhabdo Book Order on Amazon Connect With Me Joe-Cannon.com SupplementClarity.com YouTube About Me For over 30 years, I've been sorting nutrition facts from fiction, busting myths and helping people understand dietary supplements using clinical research as my litmus test. I have an MS in exercise science and a BS in biology & chemistry. I've written several books, including Rhabdo, the first book about exercise-induced rhabdomyolysis. Disclaimer Episodes are for information only. I'm NOT a medical doctor. NO medical advice is given or implied. ALWAYS consult your physician for the best health advice for you. I participate in the Amazon Associates program which means if you click on a link to amazon and make a purchase, I may make a small commission at no extra cost to you.
Dr. Armando Hernandez-Rey is Conceptions Florida's medical director and triple-board certified in Reproductive Endocrinology and Infertility; Obstetrics and Gynecology; and Surgery. Dr. Armando Hernandez-Rey has over 24 years of experience in the medical field. He graduated from Universidad Autonoma de Ciencias Médicas de Centro America in 1998. He attended medical school at the University of Miami Miller School of Medicine for his specialization in Obstetrics and Gynecology. He specializes in treating patients with polycystic ovary syndrome (PCOS), recurrent pregnancy loss (miscarriage), and severe endometriosis. He is especially interested in fertility preservation (eggfreezing) for patients who must delay childbearing for personal or medical reasons, including cancer and systemic lupus erythematosus. Dr. Hernandez-Rey is an assistant clinical professor at the Herbert Wertheim College of Medicine at Florida International University and serves as an ad-hoc reviewer for the prestigious peer-reviewed journal, Fertility and Sterility. He has also published several articles and chapters in medical literature. Website https://www.conceptionsflorida.com Instagram https://www.instagram.com/conceptionsflorida/ Facebook https://www.facebook.com/conceptionsfl Tiktok https://www.tiktok.com/@conceptionsflorida For more information about Michelle, visit: www.michelleoravitz.com The Wholesome FertilityFacebook group is where you can find free resources and support: https://www.facebook.com/groups/2149554308396504/ Instagram: @thewholesomelotusfertility Facebook:https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast, Dr. Hernandez -Ray. Armando Hernandez-Rey MD (00:04) Thank you, Michelle. Thanks for the invitation. It's really an honor and a privilege to be on your show, on your podcast. Michelle (00:09) Yes, well, I've heard a lot about you over the years because I've had a lot of patients go to you. And one of the things that I've heard is that you do really well with surgeries and fibroids and you're able to in and but in a way that still preserves fertility. So that was one of the things that I've learned. Armando Hernandez-Rey MD (00:32) Well, reproductive endocrinology and infertility as a subspecialty is a surgical subspecialty as is OB -GYN, which is a mandatory path to get to the infertility route. Unfortunately, a lot of the newer generation is not operating because they're not taught, not through no fault of their own, they're not taught. The reality is that it is... Michelle (00:47) Mm -hmm. Armando Hernandez-Rey MD (00:55) for a myriad of reasons this phenomenon has happened. Number one, the minimally invasive surgery tract has been developed where you have the person who's really just really perfected their obstetrical skills. And then you have the gynecologic oncology route and the pelvic urogynecology or pelvic reconstruction route and the minimally invasive surgical route. And a lot of the reproductive endocrinologists, have said, you know what, I'm going to forego surgery and I'm going to refer it out. My personal philosophy, and this is in no way critical to absolutely anybody, it's just my own, is that I went into medicine to be a surgeon, I actually wanted to be an orthopedic surgeon. I ended up not liking it, I had a very bad fracture when I was in my teens playing competitive soccer, and I really had some PTSD from that fracture, so I just couldn't see myself doing orthopedic surgery, but I somehow found my way towards OBGYN, absolutely loved it. And eventually towards the reproductive endocrinology route, which encompasses a lot of surgery, should you allow it. And so yes, like you said, fibroids are an important part of fertility. you, tubal reconstruction used to be much more important than it is now. People are more, are bypassing that route and going directly to in vitro fertilization. Endometriosis, as I said, I was running a little bit late today. I was in a very, very complex endometriosis case with a patient with bilateral endometriomas and complete frozen pelvis and scar tissue. And, you know, just a little bit longer, I had to work with the colorectal surgeons to do some resection of the colon because it was, you know, endometriosis is such an awful, awful disease. So yes, to answer your question, I... Michelle (02:41) Yeah. Armando Hernandez-Rey MD (02:44) Absolutely love surgery. I think it's an integral part of the infertility journey to get a patient from being infertile to getting them to a high level of success with any sort of treatment. And hopefully it's more conservative than having to resort to artificial insemination or in vitro and with just surgery and corrective surgery, we can help the couple achieve a pregnancy. Michelle (03:07) Yeah, and I think it's important because I think that a lot of people might not realize that there are certain people that specialize in this or have experience doing that, doing surgery and really getting in there because it is important to find somebody who's specialized if you have a complicated case. Armando Hernandez-Rey MD (03:23) I think it's important. I think people feel well taken care of. Again, my perception, people feel well taken care of when everything is done in house. Meaning, you know, there's no messages that get lost as you refer a patient out who may have the minimally invasive surgery knowledge, but not necessarily the focus on infertility, reproductive endocrinology. Michelle (03:33) Mm -hmm. Armando Hernandez-Rey MD (03:50) specialist has and I think people feel comfortable with that. Michelle (03:52) Yeah, absolutely. Because there's some people that will take out fibroids, but they're not doing it with fertility in mind. You know, for many women, it could just be just taking out fibroids, but you're doing these things with fertility in mind. Armando Hernandez-Rey MD (04:07) There are many great surgeons out there that are not infertility specialists. You know, I want to make sure that I'm clear. I just think that I was, I always love surgery. I happen to do surgery and I feel my patients feel very comfortable with me doing the surgery and not being referred out. It's what I think. You know, the journey, the infertility journey is very complex. It requires a lot of a woman in particular more than the male and to be Michelle (04:25) Yeah. Armando Hernandez-Rey MD (04:36) you know, passed around, it gets complicated. And I think it's nice to be able to offer that service to patients. Michelle (04:44) Yeah, for sure. And then you do specialize in miscarriages. Armando Hernandez-Rey MD (04:49) Sure, I mean, I think we all really have a focus on on as you know, we're all specialized in miscarriages and and PCOS and all that there's some people that tend to see More miscarriage patients or they people will refer miscarriage patients to us We have a particular kind of focus on that, you know, I think a lot of it is genetic, a lot of it is immunologic, a lot of it is just taking a holistic approach to things and not just focusing on one or the more common causes of infertility. And even now, I think that, you know, the use of supplements, which maybe 15 years ago was maybe considered some snake oil. Now, I think there's a lot of provocative data that has shown that supplements do work, in particular in Michelle (05:18) Mm -hmm. Armando Hernandez-Rey MD (05:44) cases with recurrent miscarriage. And now we have the ability to measure those levels and we are now ability to supplement those levels and they have tremendous impact positively on these patients. Michelle (05:57) And what supplements have you seen help with miscarriages? Armando Hernandez-Rey MD (06:02) Well, I think a lot of it has to do with what the cause of the miscarriages is. Oftentimes, believe it or not, miscarriages can alluded to fibroids, it could be anatomical, sub -mucosal myoma. Well, there's not gonna be any supplement that's gonna help with that. It's just purely the surgical route or the diminished ovarian reserve, Michelle (06:07) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (06:29) cause for recurrent miscarriages, which is older women or ovaries that are behaving or eggs that are behaving older than what their chronological age would dictate, you have a higher chance for aneuploidy. And in those cases, there's a variable cocktail of supplements that we use, including ubiquinol, including N -acetylcysteine, including vitamin E, even melatonin has been shown to be very, very effective. And I can go on and on, even alpha lipoic acid. Michelle (06:50) Mm -hmm. Armando Hernandez-Rey MD (06:57) as well. There's some very nice studies coming out of Mayo Clinic that have shown that aflalipoic acid is very, very good for recurrent miscarriages. So again, things that we thought were, well, they can't hurt, now we know that they absolutely help. Michelle (06:57) Yeah. Right. Yeah. I mean, that's great because it just helps to know that there's something that people can do that really does make a difference. And it's not just like in theory with miscarriages when it comes to immunology. I'd love to talk about that because I know that that's a big one. Actually, I did see a study that showed that women who have are more sexually active, that their immune system calms down. It behaves differently in the luteal phase. Armando Hernandez-Rey MD (07:31) Mm -hmm. Michelle (07:44) so that it's able to receive life so that it's not seeing like the sperm as an invader the, yeah. Armando Hernandez-Rey MD (07:50) So women that are more sexually active than others, it's probably a function of repeated antigen exposure, which is the more the woman is exposed to the antigens of the sperm, more there becomes an acquiescence by the immune system to be more receptive of that embryo. Because remember, the embryo is Michelle (08:06) Mm -hmm. Armando Hernandez-Rey MD (08:19) a haplotype, meaning it's half female, half the woman, half the mother, and half the male. And the only genes that the immune system of the mother has got to harbor the pregnancy are her own. And so oftentimes the immunologic processes are heightened because it does not recognize the male antigens that are formed part of the embryo in general. But as a whole, I mean, recurrent pregnancy loss, Michelle (08:33) Mm -hmm. Right. Armando Hernandez-Rey MD (08:47) is, is a small portion of the general population and, it's skewed towards advanced maternal age and advanced paternal age. so the immunologic component, while absolutely important, I think it's the one where we're still not a hundred percent sure how to absolutely treat it. Although supplementation and. immune suppression definitely are known to work. It's the testing that I think we still need a lot more work in doing because you know people talk about NK cells and you know that was part of my thesis when I was a fellow. So we talk about NK cells and ANA and antiphospholipids and all of that and the reality is that these tests have very very poor sensitivity in the realm of immunologic infertility or reproductive immunology. And so you may have COVID and then you can test positive or lightly positive for NK cells. And so I think that the overwhelming response by the treating physician is, well, they're positive, they must be immunologically incapable of handling a pregnancy. So therefore we should treat. Michelle (09:40) Mm -hmm. Armando Hernandez-Rey MD (10:04) with nowadays what we use as intralipids. Back in the day, we used to use IVIG that has kind of fallen by the wayside a little bit. I think it's better to treat empirically than to have someone treat or test for all of these different immune markers that really, really in the presence of immunology and reproductive immunology, They have very low sensitivity. Now if you're treating or you're looking for lupus or rheumatoid arthritis or mixed collagen disorder or Sjogren's for sure, they are your go -tos every single time. Michelle (10:44) And what about a PRP for ovaries? What has do you do offer that? Armando Hernandez-Rey MD (10:50) ovaries. American study of reproductive medicine came out with a black box warning that they do not recommend PRP for ovaries. Now, PRP for recurrent implantation failure, poor lining development, there is some very robust data that there may be some room or benefit for this. Michelle (10:57) okay. Mm -hmm. Armando Hernandez-Rey MD (11:14) And we do do offer that. We do not offer intra ovarian PRP because ASRM has a huge black box warning on this. It's a liability. The potential for infection is there. Tubo ovarian abscess have been reported, adhesions, periovarian adhesions, and with very little to no benefit whatsoever. I mean, the whole premise for it is that we are... Michelle (11:16) Okay. wow, okay, I didn't know that. Mm -hmm. Okay, got it. Armando Hernandez-Rey MD (11:42) regenerating the follicle complex and therefore improving egg quality and that definitively has not been shown to be the case. Although anybody who suffers from that as I would be would be like, slide me up. But unfortunately, you know, it's very easy for us to fall prey to things that we desperately want without having the medical literature to corroborate it or back it up. Michelle (11:49) Got it. Right. Got it. So that's actually showing to not necessarily be what a lot of people originally thought, but for the uterus, it has been shown to help. Armando Hernandez-Rey MD (12:15) Yes, we are doing PRP installations and very select group of women with those diagnoses in particular. And. Michelle (12:25) So who would be a good candidate? Somebody who's had failed transfers, inflammation. Armando Hernandez-Rey MD (12:30) Yes, someone with very high quality embryos, high quality embryos that are not getting pregnant. Also patients, for example, patients who have adenomyosis that do not develop a nice lining, a thickened lining. Those have been shown. Our numbers are very small, you know, by no means. Michelle (12:42) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (12:53) they are in the realm of what a randomized controlled trial should be. We're following the data from the randomized controlled trials and from the literature that's out there. So patients with adenomyosis who have poor lining development, recurrent implantation failure, so patients with euploid embryos, that means a normal embryo that's tested that looks to be high quality. Also, after a second implantation failure, we'll... offer that to the patient as a possibility. Michelle (13:19) Mm hmm. Got it. Awesome. And then also we were talking about Ozempic pre -talk. So I'd love to get your... Yes. Yeah. Ozempic babies. Armando Hernandez-Rey MD (13:24) the topic du jour these days, right? It's right. So as we were discussing, I mean, this, this phenomena is not really a phenomenon that's surprising at all. It is just a, a byproduct, a side effect of, of how the medication works and the effects that positive effects that I have on women with in particular, and ambulatory disorders, specifically polycystic ovarian syndrome, which is often tied to or associated with insulin resistance, obesity, sometimes even overt. type 2 diabetes and the elevated levels of insulin, the elevated testosterone levels, they all work together to create this sort of environment within the ovary and the system of the female which creates an ovulatory disorder or dysfunction. And as a woman loses weight by virtue of the way that these GLP1s or glucocortes Michelle (13:58) Mm -hmm. Armando Hernandez-Rey MD (14:22) Glucagon like peptides work They're very successful. They're very good at number one slowing gastric emptying which in turn slows down the release of sugar into the blood system to the Number one number two it stops the the release of glucose produced by the liver and Number three increases insulin levels so increase insulin levels helps get the the the sugar into the muscles out of the circulation and out of stimulating the ovaries and the theca cells to produce more androgens which then get produced produce more estrogen which then stops the hypothalamic pituitary ovarian axis from functioning correctly and as these levels drop patients automatically begin to have spontaneous ovulation if the system is working and the male has normal sperm and they're sexually active. this is how the ozempic baby phenomena occurs. And what we discussed also is that the concern is of the downstream consequences of ozempic babies given that the current recommendations are to have at least a two month washout period before anybody starts to try to conceive. Michelle (15:32) So two month washout means like really not trying anything. Yeah. And then also, I know like naturally, myonocytol is really helpful as well for insulin resistance. It might take a little longer. And then also metformin has been used as well. Armando Hernandez-Rey MD (15:37) No exposure, right? No exposure. Yeah. Yes. So, my own hospital is, is a, is a great product. my own hospital alone, although you will find oftentimes my, my own hospital with a D chimeric, hospital and really the literature shows that my own hospital by itself is the one that truly has the most benefit might be hard to find. Michelle (16:06) Right, yeah. Right because for a little while they said my own hospital and dechiro, but now they're going back to saying just my own ocital, correct? Armando Hernandez-Rey MD (16:23) Yeah, well the way that it's normally found in the body is at a ratio of 20 to 1. And that's what those supplements show, 20 to 1. Although we know now that in the ovary it's almost 40 to 1 ratio of myoinocytol to D -chimeric, inocytol. Michelle (16:30) Mm -hmm. Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (16:49) Myo Inositol is actually not an essential vitamin, but it's considered like a vitamin, but it's in the category of B8 It's a glucose like peptide that basically helps to Help the system function by processing the circulating blood sugar in a way that's more physiologic and there by lowering insulin levels and thereby also helping tremendously with Michelle (16:56) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (17:16) regularity of cycles and even spontaneous ovulation as well. And metformin obviously is medication that's been around for many, many years. It is somewhat of a controversial drug. It is an anti -aging drug even these days because we know that insulin levels are so profoundly toxic for aging for the muscle and for the system in general. Michelle (17:29) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (17:45) And so we know it works, we know that it helps with the efficiency of insulin. And so it's certainly been used for many, many, many years in the presence of patients with polycystic ovarian syndrome. I would challenge people to be a little bit more meticulous about using it in patients who are the lean PCOS. Michelle (18:11) Right. Armando Hernandez-Rey MD (18:11) or the skinny PCOS or the ovulatory PCOS even though insulin levels have been shown to be higher, slightly higher in... Michelle (18:19) So you're talking about being cautious with metformin, not necessarily myonositol. Yeah, yeah. Armando Hernandez-Rey MD (18:22) Metformin, you also don't want very high levels of myelonostetal because they can be, you know, there is some quote unquote toxicity. I think the recommendations are up to four grams per day. I think all the recommendations are four grams per day in two divided doses, two grams in the morning and two grams at night. I've seen patients be on eight grams and 10 grams and toxicity really starts happening around the greater than 10 gram dose. Michelle (18:29) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (18:52) I in our office we only use it, you know, what's recommended which is the four gram total per day two grams in the morning two grams at night and I don't think it's the end -all be -all I don't think it's you know treating anything in life is multi -pronged. It's not just one single thing perhaps but I definitely believe very wholeheartedly that it does assist in in adjunct treatment, although we certainly have patients put patients on on myocytil and combined with Michelle (19:06) Yeah. Right. Armando Hernandez-Rey MD (19:20) diet and exercise and have been able to achieve pregnancies on their own, which is obviously what we want instead of having to go through treatments. Michelle (19:27) That's great. I mean, I will say that I was very surprised this past year. two different patients came from different, different places, not yours, it was other doctors, but I think the nutritionist there suggested metformin when they did not have insulin resistance or PCOS for egg quality. Armando Hernandez-Rey MD (19:47) Yeah, I'm not familiar with any studies that have shown that have improved that. In fact, when I was a fellow, we were, just as I was coming into fellowship, where I trained, Rutgers was involved with a very well known and publicized study, it's called the PP COAS study, which looked at patients on placebo versus metformin alone versus metformin with Clomid, sorry. placebo versus clomid versus clomid with metformin and there was no difference in pregnancy rates or anything else. I'll go one step further with them going back to the myonocytol. It has even been shown to decrease the rates of gestational diabetes and so in our patients with PCOS with who are you know Michelle (20:18) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (20:39) Stage one, type one obesity, type two, we'll continue them on the myonostetal throughout the pregnancy and when they leave us and go to their OB -GYN, in our referral letter back, we'll say that we're recommending for her to continue on myonostetal because there have been improvements in sugar levels and glycemic control and reduction in gestational diabetes overall. Michelle (20:54) Yeah, that's good to know. another big one is vitamin D. A lot of people, even though we're in Florida here, we have a lot of sun. A lot of people are very deficient in vitamin D. Armando Hernandez-Rey MD (21:11) Yeah, What it is is a combination of things. Number one, we're not as sun exposed as you think we are. You know, we're always in a car, we're always indoors, it's very hot. And yes, we go out to the beach and there is a lot of sun, but we become very, very sensitive to the sun and to the untoward effects of the sun. Michelle (21:17) Mm -hmm. Armando Hernandez-Rey MD (21:35) So we protect ourselves tremendously. That's number one. Number two is that I think the levels are set higher than what the average person can sustain with just diet and sun exposure. And actually the recommendations now in the infertility world that when you order a vitamin D from Quest, they'll tell you that the levels are, you want them at Michelle (21:38) Mm -hmm. Armando Hernandez-Rey MD (22:04) definitively above 20 Certainly above 30 and now recently now the recommendations are that for them to go above 40 and and and Yeah, I'm not yeah, so I heard I've read 40 I it was a Paper that came out of Either the Lancet or Michelle (22:11) Yes, yep, I've been hearing that or even 50. Yeah. Armando Hernandez-Rey MD (22:27) or fertility necessarily, anyone, one of, that they recommend now for vitamin D levels to be above 40. So that's really hard. I mean, I work really hard. I take a lot of vitamin D and I'm just barely scraping like 50. You know, I take about 5 ,000 units a day, which is what we're recommending nowadays, 5 ,000 units of vitamin D. And I take that every single day and I barely scratch, Michelle (22:38) Mm -hmm. Yeah. Armando Hernandez-Rey MD (22:56) you know, 45, 50 every time I get an average check. So I'm not getting as much sun as I think I am, number one. I am out fairly often. I do play some golf, not enough. And yet it's not enough. So definitely supplementation's important. Michelle (23:03) Mm -hmm. Yeah, magnesium is also important. That's another thing. It's to not be deficient in magnesium because magnesium plays an important role of our absorption of D, which, you know, obviously doing this, I learned, I was like, that's might be deficient magnesium and be taking a lot of D and then their body's not processing, which is why it's important sometimes even in foods, foods have everything. So like, even beef liver, you know, from Chinese medicine perspective is so beneficial because it has iron, but it has it in a combination of nutrients that helps the body absorb it. Armando Hernandez-Rey MD (23:46) Yeah, B6, B12 are incredibly important for iron absorption as well. So all of these things are extremely important. Everything is all intertwined and we're just learning about this. And for us, I've really gotten grabbed hold of this whole longevity thing, hence my aura ring and all of this. And... Michelle (23:57) It is. Yeah. Armando Hernandez-Rey MD (24:09) I'm just trying to apply a lot of the things that we know today work for longevity medicine and anti -aging principles to the infertility world because it's all intertwined. It's all intertwined. Michelle (24:16) Yeah. without a doubt. It's funny because that you say that because I always say it's pretty much anti aging. Yeah. Armando Hernandez-Rey MD (24:26) Yeah, totally, totally. They're even coming up with a way to stop menopause. Michelle (24:36) wow. How? Armando Hernandez-Rey MD (24:37) which is extremely interesting. Believe it or not, recombinant antimullerian hormones. Michelle (24:42) How is that? Explain that. Armando Hernandez-Rey MD (24:46) So the way that antimullerine, the function of antimullerine hormone at the level of the ovary is that it stops follicular recruitment. That's why women with PCOS have higher AMHs and therefore they have higher egg counts and higher, they tend to go into menopause later on, et cetera. That's because they have high levels of antimullerine hormone. So by reproducing or creating it in the laboratory and then from an early stage, This is in its infancy, by the way, okay? So this is, yeah, this company, I believe she's a Harvard scientist, biochemist or something, who's coming up. My point is that, listen, that it's all intertwined, aging and even in menopause, for God sakes. Now I've been doing this for so long that I now, Michelle (25:18) It's new. Mm -hmm. Armando Hernandez-Rey MD (25:39) seeing menopausal patients who were like, you know, listen, you took care of my baby, you're a reproductive metachronologist, you understand the science, will you treat me? And, you know, like, and I realized, like, somewhere, some women got like, they got a some bad luck thrown their way because, you know, with the WHI results and the way they were interpreted, they made hormones bad. And somewhere along the way, someone said, It's okay for women to suffer from menopause, just suck it up. Like it's not okay. That's not okay. That's not okay. And so if you start from very early on and, you know, and, and really practice what you preach, which is healthcare and not sick care, which is what we practice in the United States, you know, we're just very, we, we're not proactive. We're reactive to when a patient is sick instead of early intervention, early screening and all of that. Michelle (26:25) Yeah, absolutely. Armando Hernandez-Rey MD (26:30) And that goes for the infertility world and that goes for a woman's long reproductive life extending past menopause. I think we still have a lot of challenges to overcome, but I think that we're heading in the right direction. Sorry to digress a little bit. I went off on a tangent there for a second. Michelle (26:43) Yeah, for sure. no, it's okay. But you know what? I love the passion and I love that, that, you know, ultimately is great. It's important, very important, because it's true. And I agree a lot with what you just said, that we should be proactive when it comes to healthcare. I mean, really when it comes to so many things and something else that I... that I read, it was an animal study. It was a study on, I believe it was like, I don't remember which kind of animal it was. I think it was like either sheep or cows or some form of those where they actually gave them oxytocin right before IUI. And that improved the chances of the conception rates, which I thought was very interesting because I think that that's one of the things with IUI that's missing because obviously you're taking away the connection. that is usually there when you're just under natural circumstance. And I thought it was interesting because I was looking into it for something else to understand from a Chinese medicine perspective, because they have this heart -uterusconnection, that connection, the bonding. And so what I found was interesting too is that oxytocin increases around ovulation and after intercourse. And usually what they look at it as its role is usually for labor. not so much conception. So I was just going to kind of like pick your brain on that. Any thoughts on that? Armando Hernandez-Rey MD (28:13) Well, I mean, oxytocin is secreted at the time of... I'm not sure of ovulation, I didn't know that. But definitely at the time of... Michelle (28:21) or it increases around that time, like right before ovulation in the cycle, a woman cycle. Armando Hernandez-Rey MD (28:27) What we know that it's involved is at the time of orgasm. And so this may promote uterine contractility, which is what is used for intrapartum, to promote contractility of the uterus, to promote descent and eventual delivery. And we know that it's intimately involved in orgasm, we're seeing. Michelle (28:33) Mm -hmm. Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (28:55) during intercourse and orgasm and so with you know the projection of with the secretion of oxytocin and it causing uterine contractility obviously not at the same level that it does during labor but at smaller amounts then I can see how there could be a role for oxytocin in artificial insemination. Michelle (29:18) even in fertility in general and because it's got to be there for a reason why would the body produce it around that time? Armando Hernandez-Rey MD (29:25) Well, yeah, I guess, but it's either IUI or IVF and we definitely don't want oxytocin during the IVF cycle. Michelle (29:33) Right, because you don't want to contract, right? Armando Hernandez-Rey MD (29:35) Right, because we're transferring an embryo where there should not be any oxytocin. And you can have the most beautiful embryo, but if you screw up the embryo transfer, through no fault, just because it's a difficult transfer for a myriad of reasons, and you cause uterine contractility, then there's a high likelihood of pregnancy not occurring during that time. Michelle (29:57) Right. I think it would be an interesting thing to look into for IUI. There might be something to it, because if it works with animals, and the animals obviously have similar certain functions that we do, mammals, that seems like an interesting thing. Armando Hernandez-Rey MD (30:10) Yeah. I think there's not going to be a lot of resources put into improving IUI, to be honest with you. IUI, I think it is what it is. And I mean, I think the majority of research is going to go to improving even more IVF rates, because I think ultimately patients are going to want to go more. Michelle (30:22) Mm -hmm. Yeah. Armando Hernandez-Rey MD (30:40) towards IBF, no matter how hard we try to say, hey, listen, there's this option or this option or this option. It's more become a more of an instant gratification society. Number one, number two, people are waiting longer. So therefore they're more pressed for time, if you will. And I think there will be less of a motivation to go down a treatment option that frankly, Michelle (30:48) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (31:07) You know, has a low pregnancy rate. Michelle (31:09) Right. And then my other question is, what are your, thoughts about a lower intensity cycle? like lower amounts of hormones for older women. In some cases I've heard it might be a little better. you do? Yeah, yeah. Armando Hernandez-Rey MD (31:24) We use it all the time. Yeah, we use it all the time. I think it's... a very successful option in cases with severely diminished ovarian reserve. I think that the senescent ovary does not do well with high impact medication or high doses of medication separately, but you know, jointly the medication costs are exorbitant and you end up having the same number of eggs that are mature, that get fertilized with a mini stent protocol as you do with Michelle (31:38) Okay. Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (31:59) a high dose regimen. Michelle (32:02) Okay, so you've seen good success with that. Armando Hernandez-Rey MD (32:06) Well, I mean, not good success because generally these cases are, we've seen success. Let's call it that. Because the patients that you're treating with these medics, with this protocol are patients who are POI, you know, premature ovarian insufficiency, diminished ovarian reserve, poor egg quality, high rate maniploidy. So these are your poor responders essentially. And they're very... Michelle (32:12) Yeah, okay. Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (32:34) specific factors that propel a woman to have success with this protocol compared to her twin sister with almost the same testing who doesn't do as well. Michelle (32:47) Got it. And then lastly, we talked about this in the pre -talk, let's talk about marijuana and sperm, data is showing. Yeah. Armando Hernandez-Rey MD (32:55) I don't do it myself, but I have no problem with people that do. What the data has shown that we're just becoming more and more familiar because the overwhelming number of people who are using cannabis and open about it, which is the second part, which was very difficult to conduct studies because it was so people were ostracized. They were looked at. not the wrong way and seen as in the fringe. And now it's, you know, it's so mainstream. but so now we're, we're keenly aware, of patients were able to analyze them and what we know without a shadow of a doubt that the potency of the cannabis that's being produced these days is anywhere between eight to 12 times more potent than I think I use the joke of the guys at Woodstock back in the sixties, right? Michelle (33:21) Mm -hmm. Mm -hmm. Armando Hernandez-Rey MD (33:46) where everybody was getting pregnant and everybody was high on life, all of those things. And then what we've also known, which I did mention, is that using the vape pens, whatever types of inhalers as opposed to the traditional joint, if you will, increase the potency of that by a factor of two to three. The cannabis that was already potent to begin with. Michelle (34:08) Yeah. Right. Armando Hernandez-Rey MD (34:14) So what you're seeing in males in particular, and I'm not sure that the literature is so complete on the female aspects, are that we're seeing a high levels of fragmentation. And what fragmentation is, is imagine that sperm is like an Amazon box. And inside that box, there's a porcelain doll that's wrapped in these packing cubes. They're held very, very tight. And under... Michelle (34:26) Mm -hmm. Armando Hernandez-Rey MD (34:40) The best of circumstances, those packing cubes are wound so tight, packed so tight that nothing, if I kick the box off the Amazon truck, nothing is gonna happen to the porcelain doll. Well, as fragmentation occurs and it happens under natural conditions and old guys like me, you know, patients who, occupational hazards, firefighters, exposed to toxins, a lot of people who use fertilizers, et cetera, et cetera. you see high levels of fragmentation. I'm talking about DNA fragmentation. And so what we're seeing is high levels of fragmentation at the level of the DNA of the sperm, which has significant effects on embryo quality, embryo development, and pregnancy rates, and high levels of aneuploidy, which is abnormal embryos. So, Michelle (35:10) So you're talking about DNA fragmentation. Yeah. Yeah. Mm -hmm. Armando Hernandez-Rey MD (35:33) You know, I'm not here to like, you know, slap you on the wrist and say don't smoke weed, but really that's what you're facing. And we know that this happens in women with cigarette smoking. Like this is a well -known cause of an accelerated transition to perimenopause. You know, 65 % of women who smoked a pack a day for greater than 15 years will go into menopause before the age of 40, assuming they started before their 20s. That's a pretty... Michelle (35:40) Bye. Mm -hmm. Armando Hernandez-Rey MD (36:03) ominous number, actually. Thankfully, not many women smoke these days, cigarettes anyway. So I guess the results of cannabis on females is yet to be elucidated, but we definitely have some pretty compelling evidence in terms of the male data that show that it can have detrimental or deleterious effects on sperm quality and not necessarily on numbers. Michelle (36:04) Yeah. Mm -hmm. right, which is what people look at usually when I mean, that's like the, the analysis is always on numbers shape and, numbers shape it. Yeah. And morphology and they won't necessarily look at the DNA fragmentation. That's actually not something that REIs usually initially look at. Armando Hernandez-Rey MD (36:33) Exactly. the thesis in morphology. is done in a well not initially unless there's comorbid situations or things that raise your red flags. For example, advanced paternal age, we always do it. Particularly in egg donor cycles, right? Because patients will be like, well, I'm using an egg donor and why don't I have bad energy? Well, because your husband could be 70 or 60 and Michelle (37:11) Yeah. Armando Hernandez-Rey MD (37:14) And then their fragmentation is completely elevated and through the roof. So yeah. So, you know, firefighters, occupational hazards. Michelle (37:18) Right. So, yeah, it's important. It's important for people to hear this because they can go in and say, the semen analysis was perfect. But that, like what you just said, is not really checked. So they may not, in a healthy, like, younger guy. Armando Hernandez-Rey MD (37:35) It's not as nuanced as we once thought it was. Michelle (37:38) Yeah. Yeah. Interesting. It's, it's fun. It's always fun for me to talk to our, our ease, you know, just to get, to pick your brain and get your thoughts. and you're my neighbors. So it's pretty cool. Armando Hernandez-Rey MD (37:50) That's right. Thank you very much for the invitation. This was really fun. We spoke about a wide array of different topics here. So this was really nice to connect this way. Michelle (37:53) Yeah. Yeah. Yeah, for sure. And I know that a lot of people are going to be like, this is interesting information. Cause I know that what you just mentioned, a lot of it is not common knowledge. people don't know automatically hear about this or really know to think about asking about it. So, so I appreciate all your information, all your good, good data. And, for people who would like to work with you or in town, how can they find more about you? Armando Hernandez-Rey MD (38:27) Well, we are at Conceptions Florida. We have two offices in Merritt Park, Coral Gables and one in Miramar and hopefully soon also in Boca. And I'm there Armando Hernandez -Ray, MD I'm sure. Easy to find these days on Google, but I'm happy to help in any way that we can. We've been doing this for a long time, quite successfully, thankfully. And we take a lot of pride, humbly speaking, but probably also. in having a good footprint in South Florida and the infertility world and trying to offer the best care possible. Michelle (39:01) Awesome. Well, this was such a pleasure and thank you so much for coming on today. Armando Hernandez-Rey MD (39:05) Thank you, Michelle.
It's In the News! A look at the top diabetes stories and headlines happening now. Top stories this week: The Eversense CGM could soon be approved for one year of continuous use, the first generic GLP-1 medication is launched, a new company tauts and all-in-one sensor and pump infusion set, a new diabetes accessory in the Roblox game, and more! Find out more about Moms' Night Out Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom Edgepark Medical Supplies Check out VIVI Cap to protect your insulin from extreme temperatures Learn more about AG1 from Athletic Greens Drive research that matters through the T1D Exchange The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX In the news is brought to you by Edgepark simplify your diabetes journey with Edgepark XX The first ever generic GLP-1 medication will soon be available in the US. It's a generic of Victoza, originally approved by the FDA in 2010 for diabetes, is part of the same class of drugs that includes Ozempic and Mounjaro. Liraglutide is Glucagon-like peptide-1 receptor agonists (otherwise known as GLP-1s or GLP-1 RAs) are a class of incretin drugs that mimic the body's natural hormones to help treat diabetes and obesity. However, the popularity of the drugs has spiraled out of control at times, leading to shortages and supply chain issues in the US and abroad. The arrival of a GLP-1 generic drug provides reasons to be hopeful for doctors and patients alike, but there are also caveats. Couple of caveats - liraglutide is injected once daily (vs. weekly) and many doctors say it doesn't work as well for as many people as semaglutide and terzepatide. No confirmation on the price Two other generic options are being developed and could launch in December 2024. Patents for newer GLP-1 medications like Ozempic and Wegovy won't expire until several years down the road https://www.healthline.com/health-news/victoza-generic-glp1-drug-available XX Senseonics plans to launch a 365-day sensor in the U.S. in the fourth quarter of this year. A one-year Eversense CGM could be a game changer for the company. In 2024, Senseonics expects to more than double U.S. new patient starts and increase the global installed base by around 50%. The growth is built on the current 180-day version of Senseonics' implantable Eversense CGM. Eversense's 180-day sensor can need calibrating twice a day, something Senseonics CEO Tim Goodnow said “has been a competitive disadvantage.” Users calibrate the 365-day sensor once a week. Senseonics is in talks with insulin pump manufacturers about integrating its Eversense CGM with their devices but has yet to commit to a timeline for finalizing an agreement. https://www.medtechdive.com/news/senseonics-365-day-cgm-2025-sales/719717/ XX People who take Ozempic or Wegovy may have a higher risk of developing a rare form of blindness, a new study suggests. Still, doctors say it shouldn't deter patients from using the medicines to treat diabetes or obesity. Last summer, doctors at Mass Eye and Ear noticed an unusually high number of patients with non-arteritic anterior ischemic optic neuropathy, or NAION, a type of eye stroke that causes sudden, painless vision loss in one eye. The condition is relatively rare — up to 10 out of 100,000 people in the general population may experience it — but the doctors noted three cases in one week, and each of those patients was taking semaglutide medications. The risk was found to be greatest within the first year of receiving a prescription for semaglutide. The study, published Wednesday in the medical journal JAMA Ophthalmology, cannot prove that semaglutide medications cause NAION. And the small number of patients — an average of about 100 cases were identified each year — from one specialized medical center may not apply to a broader population. The ways that semaglutides interact with the eyes are not entirely understood. And the exact cause of NAION is not known either. The condition causes damage to the optic nerve, but there is often no warning before vision loss. For now, patients who are taking semaglutide or considering treatment should discuss the risks and benefits with their doctors, especially those who have other known optic nerve problems such as glaucoma or preexisting visual loss, experts say https://www.reuters.com/business/healthcare-pharmaceuticals/wegovy-ozempic-linked-with-sight-threatening-eye-disorder-study-2024-07-03/ XX We got some updates at ADA about the over the counter CGMS Dexcom Stelo and Abbot's Libre. Dexom plans a late august launch of stelo, which you'll order from their website – it won't be physically in stores. Abbott also plans to sell its wellness-oriented Lingo device this summer through an e-commerce website. That's a sensor that's been available in other coutnires for a while, but was recently okayed in the US. It's not meant for people with diabetes. The Libre Rio is designed or adulst with type 2 who don't use insulin. No timing yet on that product's launch. Neither Abbott nor Dexcom have disclosed pricing for the upcoming products. https://www.medtechdive.com/news/abbott-dexcom-over-the-counter-cgm-launch/719928/ XX Insulet is looking to expand the label for its Omnipod 5 insulin pump for people with Type 2 diabetes. The company said Friday it recently filed with the Food and Drug Administration. Insulet presented study results at the American Diabetes Association's 84th Scientific Sessions that evaluated Omnipod 5 in people with Type 2 diabetes who were taking basal insulin or multiple daily injections. The results showed “substantial improvements in blood glucose outcomes and overall quality of life,” said study chair Francisco Pasquel, an associate professor of endocrinology at Emory School of Medicine. Omnipod 5 is currently cleared in the U.S. for people with Type 1 diabetes. Insulet hopes to expand the pump to people with Type 2 diabetes, with an expected launch in early 2025. The FDA has not yet cleared any automated insulin delivery systems for people with Type 2 diabetes, Insulet said. The company has a basal-only insulin pump, called Omnipod Go, that was cleared for people with Type 2 diabetes last year, but it does not connect to other devices. Even though Omnipod 5 is not currently indicated for Type 2 diabetes, doctors prescribe it for their patients with full reimbursement since the pharmacy channel doesn't distinguish between Type 1 or Type 2 patients, J.P. Morgan analyst Robbie Marcus wrote in a research note on Sunday. https://www.medtechdive.com/news/insulet-omnipod-5-type-2-diabetes-study/719644/ XX In the keynote address at the American Diabetes Association annual conference, FDA Commissioner Dr. Robert Califf expressed concerns about the rising rates of diabetes in the U.S. Though revolutionary medications and technologies for diabetes and weight loss continue to emerge, these treatments are vastly underused. The silver lining lies with type 1 diabetes therapies, which are showing great promise in clinical trials. “For the larger epidemic of type 2 diabetes, we're failing right now,” Califf said. “I don't say that lightly.” A huge problem, Califf said, is access. While most health insurance plans cover medical devices and medications for diabetes, without insurance, costs add up quickly. Ozempic, for example, costs nearly $1,000 per month without insurance. Studies have found that regardless of insurance status, roughly 26% of Americans skipped or delayed treatment due to cost. https://diatribe.org/diabetes-management/fda-commissioner-says-were-failing-people-type-2-diabetes XX Embecta presented two abstracts at the American Diabetes Association Scientific Sessions last weekend making the case for its insulin patch pump for Type 2 diabetes. The company submitted the device for Food and Drug Administration clearance in late 2023. The diabetes device company developed a patch pump with a larger insulin reservoir that can hold up to 300 units. Embecta, which is better known for making equipment such as pen needles and insulin syringes, has been developing its first patch pump. The company found that a device with a larger insulin reservoir could provide longer wear times and fewer disposable patches. https://www.medtechdive.com/news/embecta-insulin-patch-pump-volume-american-diabetes-association/719779/ XX Pump/CGM sensor in one The niaa signature patch pump, shown with a watch displaying current blood sugar level The niaa signature patch pump has a manual bolus button and is part of an in-development AID system. Swiss technology maker Pharmasens demonstrated a new semi-reusable tubeless patch pump and glucose sensor in the same compact device, called the niia signature, which the company says can be worn for five days. The top of the device, which includes Bluetooth connectivity and the electronic and mechanical parts to control the pump, separates from the disposable 300-unit reservoir along with the adhesive used to attach the device to the body via a steel cannula. A small button on the device allows manual bolusing. The company says an AID system will manage the device, controlled by smartphone. PharmaSens' simpler basal-bolus patch pump, the niia essential, was submitted for FDA approval in late December. Availability of the niia signature AID system has yet to be announced. https://diatribe.org/diabetes-technology/diabetes-technology-display-ada-2024 XX Edgepark Commercial XX New international consensus statement offers guidance on the care and monitoring of people who are at high risk for type 1 diabetes (T1D). This is all about screening and testing for islet autoantibodies. These individuals are classified as: At risk or Stage 0 (single autoantibody or transient single autoantibody), Stage 1 (two or more autoantibodies with normoglycemia), and Stage 2 (two or more autoantibodies with dysglycemia but without symptoms and not yet meeting diagnostic criteria for Stage 3 clinical T1D). The document was presented on June 24, 2024 in a 90-minute symposium at the American Diabetes Association's annual Scientific Sessions and published simultaneously in both Diabetes Care and Diabetologia. "This is not guidance around who to screen or when to screen. This is guidance for the hundreds of thousands of people around the world who have participated in screening, mostly through research programs, and have been identified with positive autoantibodies and need care in the clinical setting," panel co-chair Anastasia Albanese-O'Neill, PhD, APRN, CDCES, of Breakthrough T1D, told Medscape Medical News. The recommendations also include when to start insulin, and how to provide education and psychosocial support to individuals and family members of those given the early-stage T1D diagnosis. https://www.medscape.com/viewarticle/experts-advise-early-risk-monitoring-type-1-diabetes-2024a1000bpo XX Roblox has added a diabetic option, complete with insuli pen and Dexcom You can find it in the marketplace JDRF – now breakthrough t1d – started a world in roblox a couple of years ago as well Roblox is a super popular online game that a lot of kids play. https://www.roblox.com/games/5823990610/Breakthrough-T1D-World XX FFL next week! Join us again soon!
In this episode, we feature Liver Boost, a vital supplement from MSW Nutrition. Perfect for travelers, Liver Boost supports your liver in detoxifying and managing stress more effectively, ensuring you remain energized and healthy throughout your travels. https://www.mswnutrition.com/products/liver-love 5 KEY TAKEAWAYS 1.Vitamin Vigilance: Packing and taking your specific vitamins, like Liver Boost and Vitamin D, is crucial to fend off illnesses during travels. 2.Hydration and Healthy Snacks: Carrying a water canteen and healthy snacks like masa chips and sardines helps maintain energy levels and avoid unhealthy food options. 3.Movement Over Gym: Opting for physical activities like walking and cycling rather than gym workouts can be more enjoyable and effective during travels. 4.Meal Discipline: Sticking to your meal plan and avoiding deviations ensures you enjoy your trip without dietary regrets. 5.Reflective Journaling: Keeping a travel journal aids in processing experiences and learning from them, enhancing personal growth. TIMESTAMPS 00:00 - Start 02:00 - Importance of taking vitamins on trips 08:00 - Benefits of carrying a water canteen and healthy snacks 12:00 - Choosing physical activities over traditional gym workouts 16:00 - The significance of adhering to a meal plan 20:00 - The therapeutic benefits of journaling during travel RESOURCES MENTIONED 1.Vitamin D and Immune Function - Provides insight into how Vitamin D supports the immune system. Link 2.Liver Boost and Detoxification - Discusses the role of supplements like Liver Boost in detoxification. Link 3.Glucagon and Blood Sugar Regulation - Explains how glucagon helps in regulating blood sugar levels during physical activities. Link
Why is weight loss more important now than ever before? Weight gain and obesity are rising globally due to sedentary lifestyles and unhealthy diets, posing serious health risks like diabetes and heart disease. Weight loss is crucial to mitigate these threats and enhance overall well-being. Prioritising balanced nutrition and regular exercise is vital for a healthier future. Join us for the latest episode of SparX with Santhosh Kumar, CTO at Cure.fit, who is a fitness and weight loss expert. In this episode, Santhosh simplifies the science behind obesity, weight gain, and weight loss and elaborates on the different factors contributing to the same. Resource List: What is Glucagon-like Peptide 1 (GLP 1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812410/ The DIETFITS Randomised Clinical Trial Study: https://pubmed.ncbi.nlm.nih.gov/29466592/ Energy Balance Model Study by Kevin D Hall: https://pubmed.ncbi.nlm.nih.gov/35134825/ The Hungry Brain book by Stephan J. Guyenet, Ph.D.: https://amzn.in/d/4YSuhmj Switch: How to Change Things When Change Is Hard, book by Chip Heath and Dan Heath: https://amzn.in/d/4yhHqF6 Article by Express Healthcare on Apollo's Health of Nation Report: https://www.expresshealthcare.in/news/apollo-unveils-4th-edition-of-its-health-of-nation-report/442923/ What is intermittent fasting?: https://www.healthline.com/nutrition/what-is-intermittent-fasting GLP-1 Agonists: https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/byetta/faq-20057955
Scott and Jenny Smith define diabetes terms In this Defining Diabetes episode we define glucagon. This BetterHelp link saves 10% on your first month of therapy Try delicious AG1 - Drink AG1.com/Juicebox I Have Vision Use code JUICEBOX to save 30% at Cozy Earth Get Gvoke HypoPen Eversense CGM Learn about the Medtronic Champions CONTOUR NextGen smart meter and CONTOUR DIABETES app Learn about the Dexcom G6 and G7 CGM Go tubeless with Omnipod 5 or Omnipod DASH * Get your supplies from US MED or call 888-721-1514 Learn about Touched By Type 1 Take the T1DExchange survey *The Pod has an IP28 rating for up to 25 feet for 60 minutes. The Omnipod 5 Controller is not waterproof. A full list of our sponsors How to listen, disclaimer and more Apple Podcasts> Subscribe to the podcast today! The podcast is available on Spotify, Google Play, iHeartRadio, Radio Public, Amazon Music and all Android devices The Juicebox Podcast is a free show, but if you'd like to support the podcast directly, you can make a gift here or buy me a coffee. Thank you! Disclaimer - Nothing you hear on the Juicebox Podcast or read on Arden's Day is intended as medical advice. You should always consult a physician before making changes to your health plan. If the podcast has helped you to live better with type 1 please tell someone else how to find the show and consider leaving a rating and review on Apple Podcasts. Thank you! The Juicebox Podcast is not a charitable organization.
Glucagon-like peptide 1 (GLP-1) is a hormone primarily known for its role in regulating blood sugar levels through its effects on insulin secretion and appetite control. However, recent research has shown another significant function of GLP-1: its ability to reduce inflammation. This opens new avenues for therapeutic interventions in various inflammatory conditions and chronic diseases. In this podcast, we'll discuss GLP-1's role in reducing inflammation and how it may help you. What is GLP-1? GLP-1 is an incretin hormone produced by intestinal L-cells in response to food intake. It enhances insulin secretion from the pancreas in a glucose-dependent manner. Here's how glucose-dependent insulin secretion works: Increase in Blood Glucose Levels: After you eat, carbohydrates in your food are broken down into glucose, which is absorbed into your bloodstream, raising your blood sugar levels. Release of GLP-1: In response to the rising blood glucose levels, your intestines release a hormone called GLP-1 (Glucagon-Like Peptide 1). Stimulation of the Pancreas: GLP-1 travels through your bloodstream to your pancreas, where it stimulates the beta cells in the pancreas to release insulin. Insulin Release: The insulin is then released into your bloodstream. Insulin acts like a key, allowing glucose to enter your cells so it can be used for energy. Glucose-Dependent Nature: The important part is that this whole process depends on the presence of glucose. If your blood glucose levels are not high, GLP-1 will not signal your pancreas to release insulin. This prevents your blood sugar from dropping too low, which could cause hypoglycemia (dangerously low blood sugar levels). GLP-1 also slows gastric emptying and reduces appetite, which collectively help manage postprandial blood glucose levels. GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R), which is expressed in multiple tissues, including the pancreas, brain, heart, and immune cells. The Link Between GLP-1 and Inflammation Inflammation is a complex response to harmful stimuli such as pathogens, damaged cells, or irritants. Chronic inflammation contributes to many diseases, including cardiovascular diseases, diabetes, and neurodegenerative disorders. How does GLP-1 reduce inflammation? Modulation of Immune Cells: GLP-1 influences various immune cells, including macrophages, T cells, and dendritic cells. It has been observed to shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, reducing the secretion of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. This shift plays a crucial role in dampening the inflammatory response. Inhibition of Nuclear Factor-kappa B (NF-κB) Pathway: NF-κB is a transcription factor that regulates the expression of genes involved in inflammation. Activation of GLP-1R has been shown to inhibit the NF-κB pathway, thereby reducing the transcription of pro-inflammatory genes. This inhibition helps in lowering the levels of inflammatory mediators in the body. Reduction of Oxidative Stress: GLP-1 reduces oxidative stress by increasing the expression of antioxidant enzymes. Oxidative stress is a significant driver of inflammation, and by mitigating it, GLP-1 helps in lowering the inflammatory burden. This is particularly beneficial in conditions like atherosclerosis and diabetes, where oxidative stress is a major pathogenic factor. Cardiovascular Protection: Chronic inflammation is a well-known risk factor for cardiovascular diseases. GLP-1 and its analogs have been shown to improve endothelial function, reduce vascular inflammation, and protect against atherosclerosis. These effects are mediated through the reduction of inflammatory cytokines and oxidative stress, as well as the improvement of lipid profiles. Neuroprotection: Neuroinflammation is a critical component of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. GLP-1 analogs have demonstrated neuroprotective effects by reducing neuroinflammation, improving neuronal survival, and enhancing cognitive function. These benefits are attributed to the reduction in pro-inflammatory cytokines and the enhancement of neurotrophic factors. Therapeutic Implications The anti-inflammatory properties of GLP-1 have significant therapeutic implications. GLP-1 receptor agonists, initially developed for the treatment of type 2 diabetes, are now being explored for their potential in treating various inflammatory and chronic diseases. Type 2 Diabetes and Metabolic Syndrome: The dual action of GLP-1 in regulating blood glucose and reducing inflammation makes it a promising therapeutic agent for managing type 2 diabetes and its complications. Cardiovascular Diseases: Given the role of inflammation in atherosclerosis and other cardiovascular conditions, GLP-1 analogs could offer cardiovascular protection and improve outcomes in patients with heart disease. Neurodegenerative Disorders: The neuroprotective and anti-inflammatory effects of GLP-1 analogs present a potential therapeutic strategy for slowing the progression of neurodegenerative diseases and improving cognitive function. Inflammatory Bowel Disease (IBD): Preliminary studies suggest that GLP-1 analogs may help in reducing inflammation in IBD, offering a novel treatment approach for this chronic inflammatory condition. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
Glucagon-like peptide-1 (GLP-1) is a hormone naturally produced in the intestines during meals. It helps regulate blood sugar and weight by increasing insulin, slowing stomach emptying, and promoting fullness. Medications like Ozempic® and Wegovy® mimic the effects of GLP-1 but can be expensive and have unpleasant side effects. Listen in this week as Dee explores research on foods and probiotics that naturally boost GLP-1, offering similar benefits without the high costs and side effects.References:De Silva, A., & Bloom, S. R. (2012). Gut hormones and appetite control: A focus on PYY and GLP-1 as therapeutic targets in obesity. Gut and Liver, 6(1), 10–20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286726/Hira, T., Trakooncharoenvit, A., Taguchi, H.;,Hara, H. (2021). Improvement of glucose tolerance by food factors having glucagon-like peptide-1 releasing activity. International Journal of Molecular Sciences, 22(12), 6623. https://www.mdpi.com/1422-0067/22/12/6623Perraudeau, F., McMurdie, P., Bullard, J., Cheng, A., Cutcliffe, C., Deo, A., Eid, J., Gines, J., Iyer, M., Justice, N., Loo, W. T., Nemchek, M., Schicklberger, M., Souza, M., Stoneburner, B., Tyagi, S., & Kolterman, O. (2020). Improvements to postprandial glucose control in subjects with type 2 diabetes: A multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diabetes Research and Care, 8(1), e001319. https://drc.bmj.com/content/8/1/e001319Link to purchase GLP-1 Probiotic: https://pendulumlife.com/products/glp-1-probiotic
This feels like science fiction, but it's true! The conversation you're about to hear is about the next innovation in pump technology that is going to revolutionize management for people using insulin. I'm joined by Xeris Pharmaceuticals CEO Paul Edict and Beta Bionics CEO Sean Saint a week after they announced a collaboration to develop a bi-hormonal pump that has both insulin and glucagon. Time Stamps: (02:45) Paul's background and role at Xeris(04:34) Sean's background and role at Beta Bionics (06:16) How this epic collaboration came to be (08:33) Xeris on rescue glucagon(10:05) “We're not there yet, but we'll do it together” (10:41) The spirit of innovation (11:25) What hasn't this been done before? (13:05) “But what's going to happen to Gvoke pen?” (14:40) What can people get excited about?(16:00) The burden impact (16:57) The gas and brake (17:50) How is this different than AID delivery systems?(20:05) The extreme fear of low blood sugar (22:00) Anticipating possibilities and blocks (23:22) When we can expect this and FDA approval(26:51) Innovating in spite of a cure (30:24) Saving lives What to do now:Follow me @lauren_bongiorno and @riselyhealth on Instagram to stay in the loop for when new episodes drop.Learn more about our 1:1 coaching programs HERE. Listen to Paul in our prior episode on Glucagon EPISODE 96Disclaimer: Nothing you hear on the Reclaim your Rise podcast should be a substitute for personalized professional medical advice. Please always consult your physician or other medical professional before making any changes to your diet, insulin dosages, or healthcare plan.
Paul Edick and Sean Saint are CEOs of thier respective companies (Beta Bionics and Xeris). Today we talk about their new relationship and their desire to create a bi-hormonal insulin pump. Learn about the Dexcom G6 and G7 CGM Go tubeless with Omnipod 5 or Omnipod DASH * Get your supplies from US MED or call 888-721-1514 Learn about Touched By Type 1 Take the T1DExchange survey Free 14 Day Trial of Aura Eversense CGM Learn about the Medtronic Champions This BetterHelp link saves 10% on your first month of therapy Try delicious AG1 - Drink AG1.com/Juicebox Use code JUICEBOX to save 40% at Cozy Earth CONTOUR NextGen smart meter and CONTOUR DIABETES app *The Pod has an IP28 rating for up to 25 feet for 60 minutes. The Omnipod 5 Controller is not waterproof. A full list of our sponsors How to listen, disclaimer and more Apple Podcasts> Subscribe to the podcast today! The podcast is available on Spotify, Google Play, iHeartRadio, Radio Public, Amazon Music and all Android devices Disclaimer - Nothing you hear on the Juicebox Podcast or read on Arden's Day is intended as medical advice. You should always consult a physician before making changes to your health plan. If the podcast has helped you to live better with type 1 please tell someone else how to find the show and consider leaving a rating and review on Apple Podcasts. Thank you! The Juicebox Podcast is not a charitable organization.
In this episode of Diabetics doing things, Rob interviews Paul Edick from Xeris Biopharma and Sean Saint from Beta Bionics. They discuss the formal partnership announcement between Xeris Biopharma and Beta Bionics, focusing on the development of a bi-hormonal insulin pump for diabetes management. The conversation touches on the challenges and benefits of the partnership, the development process, and the potential impact on diabetes care. Topics discussed: 1. Partnership between Xeris Biopharma and Beta Bionics 2. The unique challenges faced by a bihormonal pump compared to traditional insulin pumps. 3. The formulation process of the pump and collaboration between Xeris and Beta Bionics. 4. The upcoming phase 2 and phase 3 clinical trials. 5. The importance of glucagon in diabetes management and the need for increased awareness and availability of glucagon. 6. The potential for a fully automated diabetes therapy experience. 7. The role of technology in reducing the burden of diabetes management and enhancing quality of life. 8. The journey towards regulatory approval and commercialization. 9. The historical context of glucagon use and the evolving perceptions around its importance. 10. The positive impact of the partnership on advancing diabetes care and glycemic control. Key takeaways: * The partnership between Xeris Biopharma and Beta Bionics aims to develop a bihormonal pump for diabetes management. * The collaboration involves overcoming unique challenges associated with incorporating both insulin and glucagon in the pump. * The development process includes formulation, clinical trials, and regulatory approval. * The partnership highlights the importance of increasing awareness and availability of glucagon for diabetes patients. * The ultimate goal is to provide a hands-off, automated diabetes therapy experience to improve quality of life for individuals with diabetes. References: * Xeris Biopharma * Beta Bionics 00:00 Exploring Inspiring Stories of People with Diabetes and Industry Announcements 00:18 Exciting Partnership Announcement: Xeris Biopharma and Beta Bionics Join Forces for Innovative Diabetes Solution 03:58 Revolutionizing Diabetes Care with Biohormonal Pump and Xerasol Technology 08:52 Exploring the Future of Glucagon Use and Reducing Stigma in Diabetes Management 13:41 Revolutionizing Diabetes Therapy: The Future of Automated Insulin and Glucagon Pump Systems 23:41 Overcoming Fear and Stigma: The Journey with Glucagon and the Future of Insulin Pumps 25:17 Challenges and Partnerships in Developing a Bi-Hormonal Pump for Diabetes Management 30:47 Exciting Innovations in Diabetes Care: A Look into Bi Hormonal Pumps
This week, creating a bihormonal pump – using insulin and glucagon in one device - has been the goal of Beta Bionics since before the company even had that name. Now that they've launched the insulin-only version of their iLet, we're getting an update on the dual chambered version. The big news is a new agreement with Xeris to supply that shelf-stable glucagon. But there are still a lot of questions. We're talking to the CEOs of both companies. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. Find out more about Moms' Night Out - registration is open for Denver! Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom Edgepark Medical Supplies Check out VIVI Cap to protect your insulin from extreme temperatures Learn more about AG1 from Athletic Greens Drive research that matters through the T1D Exchange The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Reach out with questions or comments: info@diabetes-connections.com
Today's guest Ginger Vieira, tells us everything we need to know about the 5 hormones affected by T1D, which impact weight loss, appetite, and insulin sensitivity. We discuss each of these hormones in detail and the positive lifestyle choices we can make to work WITH our bodies instead of against them. We also candidly discuss using Ozempic for weight management in type ones. This is the stuff no one is taught at diagnosis! Time Stamps: (04:54) The “Sorority Terms” of cells(6:40) Amalin hormone(7:42) Glucagon hormone & the overproduction of glucose(09:30) Weight management, hunger cues, & hormones(12:00) The role of protein in your diet (12:25) Glucagon continued (12:45) Somatostatin hormone (14:28) The liver and low blood sugar(16:40) Pancreatic polypeptide hormone & insulin sensitivity (22:08) Stress & basal insulin (22:30) The misunderstanding of the “dawn phenomenon”(23:49) Ghrelin hormone (26:45) Why crash diets do not work with T1D(27:42) Why lifestyle is crucial with T1D and caffeine's effect (28:44) The impact of exercise + insulin sensitivity (31:13) Ozempic (35:38) The importance of working with a coach while taking GLP 1 medicationWhat to do now: Follow me @lauren_bongiorno and @riselyhealth on Instagram to stay in the loop for when new episodes drop.Learn more about our 1:1 coaching programs HERE. Find Ginger @gingervieira.t1d and get her books HERE Disclaimer: Nothing you hear on the Reclaim your Rise podcast should be a substitute for personalized professional medical advice. Please always consult your physician or other medical professional before making any changes to your diet, insulin dosages, or healthcare plan.
***JOIN THE MASTER YOUR FASTING CHALLENGE THAT STARTS May 8th, 2024!*** New to fasting or want to get back on track? Struggling to break through a plateau? Ready to finally stop obsessing about your diet? Let's kick off spring time and prep for summer with intention, habit-building, and fast-tracking your fasting results! We'll GUIDE you how to FAST to LOSE FAT for good, and use 'fast cycling' to achieve uncommon results! Join us on May 8th for the Master Your Fasting Challenge! REGISTER HERE! Click the Link for DATES, DETAILS, and FAQs! MAY 8th CHALLENGE REGISTRATION LINK In today's episode, we dive into a detailed conversation about a study published in the Journal of Nutrients, comparing the effects of a high carbohydrate versus a high-fat shake on metabolism and glycemic control when used to break a 38-hour fast. Dr. Benjamin Bickman completed this study. The study suggests that the type of nutrients consumed when breaking a fast significantly impacts metabolic health. It highlights that low-carb, high-fat shakes are more beneficial for maintaining ketosis and glycemic control compared to high-carb, low-fat shakes. The findings underscore the importance of food choices in optimizing fasting strategies for better health outcomes. They emphasize that what you eat and when you eat matters greatly for those practicing intermittent fasting or time-restricted eating. FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins! THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! Fasting For Life Community - Join HERE New to the podcast and wondering where to start? Head to the website and download our Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice! Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Research Links: https://www.mdpi.com/2072-6643/16/1/164
GLP-1 - Glucagon-like peptide-1 - is a class of medications used to treat type 2 diabetes mellitus and, in some cases, obesity. That's the formal definition of the drugs many are using now solely to lose weight. It's the latest in the weight loss war. Nearly 48% of African American adults in the US are clinically obese, and Black women are especially affected as 4 out of every 5 Black women are obese. Is GLP-1 the magic weight loss medicine as some claim? Is obesity a disease, or a lack of will power? And what is the impact for diabetic patients who cannot get the drug because of increased demand from those who want to lose weight? Cardiologist Dr. Keith Newby on drugs and weight loss on Another View.
Mini Dose Glucagon – Featuring Gary Scheiner, MS, CDCES TAKING CONTROL OF YOUR DIABETES® - THE PODCAST! ...With Expert Endocrinologists Living with T1D, Drs. Steven V. Edelman & Jeremy PettusDrs. E and P meet with award winning Certified Diabetes Educator; Masters-level Exercise Physiologist; Owner and Director of Integrated Diabetes Services; and Author, Gary Scheiner, MD, CDCES to delve deep into the realm of glucagon, offering listeners an engaging discussion that merges all three of their practical insights. Through the conversation about glucagon's functions and its implications for diabetes management, they provide a special approach to taking a microdose of glucagon to possibly avoid and control additional problems.In this episode, we will talk about:What is glucagon?Why is glucagon in our bodies? The relationship of glucagon and those living with Type 1 and Type 2 diabetes? What is a mini-dosing glucagon? How can a mini-dose of glucagon benefit you while working out? Show Notes: Gary's website - integrateddiabetes.com/Gary's book - integrateddiabetes.com/shop-for-diabetes-supplies/Think-Like-A-Pancreas-3rd-Edition-p297816888Gary's podcast - integrateddiabetes.com/think-like-a-pancreas-the-podcast/ ★ Support this podcast ★
Welcome back to the CardioNerds Cardiovascular Prevention Series, where we are continuing our discussion of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs). This class of medications is becoming a household name, not only for their implications for weight loss but also for their effect on cardiovascular disease. CardioNerds Dr. Ty Sweeney (CardioNerds Academy Faculty Member and incoming Cardiology Fellow at Boston Medical Center), Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at Johns Hopkins Hospital), and special guest Dr. Franck Azobou (Cardiology Fellow at UT Southwestern) sat down with Dr. Darren McGuire (Cardiologist at UT Southwestern and Senior Editor of Diabetes and Vascular Disease Research) to discuss important trial data on GLP-1 RAs in patients with heart disease, as well as recent professional society guidelines on their use. Show notes were drafted by Dr. Ty Sweeney. Audio editing was performed by CardioNerds Intern student Dr. Diane Masket. If you haven't already, be sure to check out CardioNerds episode #350 where we discuss the basics and mechanism of action of GLP-1 RAs with Dr. Dennis Bruemmer. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Diving into the Data Patients with diabetes and clinical atherosclerotic cardiovascular disease (ASCVD) or who are at high risk of ASCVD benefit from treatment with a GLP-1 RA. For persons with sufficient ASCVD risk and type 2 diabetes, GLP-1 RAs and SGLT2 inhibitors can, and often should, be used in combination. "Just like we don't consider ‘and/or' for the four pillars of guideline-directed medical therapy for heart failure with reduced ejection fraction, we shouldn't parcel out these two therapeutic options...it should be both.” Setting expectations with your patients regarding injection practices, side effects, and expected benefits can go a long way toward improving the patient experience with GLP-1 RAs. Utilize a multidisciplinary approach when caring for patients on GLP-1 RAs. Build a team with your patient's primary care provider, endocrinologist, clinical pharmacist, and nurse. “This is really a cardiologist issue. These are no longer endocrinology or primary care drugs. We need to be prescribing them ourselves just like we did back in the nineties when we took over the statin prescriptions from the endocrinology domain...we need to lead the way.” Show notes - GLP-1 Agonists: Diving into the Data For which patients are GLP-1 RAs recommended to reduce the risk of major cardiac events? For patients with type 2 diabetes and ASCVD, starting a GLP-1 RA carries a Class 1, Level of Evidence A recommendation in the most recent ESC and ACC guidelines. For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk. The STEP-HFpEF trial showed that among patients with obesity and HFpEF, once-weekly semaglutide may be beneficial in terms of weight loss and quality of life. The results of the FIGHT and LIVE trials question the utility and safety of liraglutide in treating patients with advanced HFrEF. Of the over 17,000 patients enrolled in the SELECT trial, about 25% had heart failure, of which about one-third had HFrEF. Stay tuned for sub-analyses from that trial for more info! Can we still prescribe GLP-1 Ras in patients with well-controlled T2DM?
Use of second-line noninsulin diabetic medications, like Glucagon-like peptide 1 (GLP-1) agonists and sodium-glucose co-transporter-2 (SGLT2) inhibitors, is rapidly increasing for treatment of T2D and other indications. As these drugs are being used by an increasing group of fertile women, it is expected that a few of them will get pregnant and data on their safety when used in the first trimester is needed. Is periconceptional use of glucagon-like peptide 1 (GLP-1) receptor agonists associated with increased risk of major congenital malformations? In this episode, we will look at the available data (although limited) regarding these medications, focusing on specific GLP1 options.
The Elective Rotation: A Critical Care Hospital Pharmacy Podcast
Show notes at pharmacyjoe.com/episode895. In this episode, I’ll discuss why glucagon is not recommended in the calcium channel blocker poisoning guidelines. The post 895: Why is glucagon not recommended in the calcium channel blocker poisoning guidelines? appeared first on Pharmacy Joe.
The Elective Rotation: A Critical Care Hospital Pharmacy Podcast
Show notes at pharmacyjoe.com/episode895. In this episode, I’ll discuss why glucagon is not recommended in the calcium channel blocker poisoning guidelines. The post 895: Why is glucagon not recommended in the calcium channel blocker poisoning guidelines? appeared first on Pharmacy Joe.
This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose. 00:00:00 Podcast begins 00:04:00 Mike's background 00:05:15 Diving into fructose 00:13:00 Thoughts on honey and other carb sources 00:27:30 Robert Lustig rebuttal: is fructose addictive? 00:37:40 Fructose & fiber 00:47:00 How fructose affects the mitochondria 00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia 00:56:17 Is insulin the bad guy? 01:12:20 How insulin relates to diabetes, obesity, and insulin resistance 01:23:30 Balancing protein, fat and carbohydrates 01:30:00 Is fructose making us fat? 01:46:00 Final thoughts Connect with Mike: Mikefave.com https://m.youtube.com/@MikeFaveSimplified References: Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/ A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/ The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/ Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/ Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/ Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/ Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/ Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/ Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/ Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/ Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/
Today, I am blessed to have here with me Richard Smith. Richard began his keto journey for weight loss hoping to cure severe anxiety, depression, chronic fatigue, and daily debilitating migraines. During the year, Richard managed to lose over 100lbs. After reversing his illnesses and transforming his physical and emotional well-being via a ketogenic lifestyle, Richard was dedicated to helping transform the health and lives of others by providing support and supplements. In this episode, Richard discusses his past health problems, including obesity, diabetes, fatigue, depression, and anxiety. He reveals how keto transformed his well-being and life. Then, Richard dives into why cholesterol isn't the enemy and how you can determine if your cholesterol profile is actually damaged or not. Richard digs deep into insulin and leptin and how to optimize these hormones. Tune in as we chat about the problem with insulin resistance and a simple test to tell if you are insulin resistant. Reserve your FREE spot to our upcoming 5 day Keto Kickstart Challenge with Dr Eric Berg, Cynthia Thurlow, Ben Azadi & The Keto Kamp Team: https://www.ketokamp.com/keto-challenge / / E P I S O D E S P ON S O R S Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:40] Richard Speaks About His Health Problems and How Keto Transformed His Life Richard was clinically obese, diabetic, chronically tired, depressed, anxious, and experienced debilitating migraines that would make him blind. The worst part of Richard's health was his anxiety; he wouldn't be able to leave his house, car, or office. Richard never felt good enough to be around other people. Eventually, Richard realized that bread made his belly swell. So, he gave it up. Within 30 days of ditching bread, Richard lost 28 pounds. Starting keto has completely changed Richard's life; luckily, every factor of his life has improved. [26:20] Cholesterol Isn't The Enemy; In Fact, Cholesterol is Essential For Health Cholesterol is essential for life. It's imperative for cell formation, cell communication, nutrient absorption, nutrient transportation, and hormone production. The brain and the myelin sheath are made of cholesterol. Lacking cholesterol would be detrimental to your health. There is a massive miscommunication when it comes to cholesterol. LDL is proactive; it heals the body and repairs it. The two main contributing factors to heart disease are grains and seed oils. Seed oils do not help lower cholesterol. Reducing carbohydrates and seed oils is the best way to have healthy LDL. [35:00] Is Your Cholesterol Profile Damaged? Richard Explains Where Your Markers Should Be There's a simple way to see whether your cholesterol profile is damaged. Triglycerides are one of the most significant factors; aim for less than 0.5%. HDL should be greater than 1.5. The triglyceride to HDL ratio should be below one. You're in good shape if your cholesterol profile is around these markers. Remember, cholesterol is essential for life; every cell in the body is made of cholesterol. [39:45] You Can't Store Fat Without Insulin From Carbohydrates, Sugars, and Seed Oils We can't store fat without insulin. Insulin is secreted by the pancreas when we consume carbohydrates. Many people will eat carbs before going to the gym to have the energy to burn fat. However, when insulin is elevated, it tells the body to store fat. Eating carbs will make it almost impossible for us to burn fat for fuel. Insulin puts a biological lock on our fat stores and prevents them from leaving. Carbohydrates and sugars will increase insulin. Seed oils will also impact insulin; they cause insulin resistance. [42:40] The Foods You Eat Could Be Blocking Your Ability To Feel Full Leptin is a satiety hormone. It tells us that we have eaten and that we are full. Seed oils will block leptin. If you aren't feeling full, you will consume more food. Grains are high in lectins; they cause five times more fat storage than insulin. Lectins in grains will also block leptin. [49:55] Richard Reveals A Simple Test To Tell If You're Insulin Resistant As a world, we are insulin resistant. In fact, 95% of people are insulin resistant. Diabetes will start with food choices that began ten to fifteen years prior. There's a simple way to test if you suffer from insulin resistance. You have insulin resistance if you have an overhang over your pants, belt, or skirt. Restrict carbohydrates, and you will see a reduction in insulin levels. You don't need a myriad of medications to solve insulin resistance. AND MUCH MORE! Resources from this episode: Check out Keto Pro: https://theketopro.com/ Follow Richard Smith LinkedIn: https://www.linkedin.com/in/richard-smith-b810881b3/ Follow Keto-Pro Facebook: https://www.facebook.com/theketoprocom/ Instagram: https://www.instagram.com/keto_pro/ Twitter: https://twitter.com/pro_keto Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm Reserve your FREE spot to our upcoming 5 day Keto Kickstart Challenge with Dr Eric Berg, Cynthia Thurlow, Ben Azadi & The Keto Kamp Team: https://www.ketokamp.com/keto-challenge / / E P I S O D E S P ON S O R S Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you'll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?
Heather's child has type 1 diabetes and this is their glucagon story. Get your supplies from US MED or call 888-721-1514 Get Gvoke HypoPen CONTOUR NextGen smart meter and CONTOUR DIABETES app Learn about the Dexcom G6 and G7 CGM Go tubeless with Omnipod 5 or Omnipod DASH This BetterHelp link saves 10% on your first month of therapy Try delicious AG1 - Drink AG1.com/Juicebox Use code JUICEBOX to save 40% at Cozy Earth Learn about Touched By Type 1 Take the T1DExchange survey A full list of our sponsors How to listen, disclaimer and more Apple Podcasts> Subscribe to the podcast today! The podcast is available on Spotify, Google Play, iHeartRadio, Radio Public, Amazon Music and all Android devices The show is now available as an Alexa skill. My type 1 diabetes parenting blog Arden's Day Listen to the Juicebox Podcast online Read my award winning memoir: Life Is Short, Laundry Is Eternal: Confessions of a Stay-At-Home Dad The Juicebox Podcast is a free show, but if you'd like to support the podcast directly, you can make a gift here or buy me a coffee. Thank you! Follow Scott on Social Media @JuiceboxPodcast Disclaimer - Nothing you hear on the Juicebox Podcast or read on Arden's Day is intended as medical advice. You should always consult a physician before making changes to your health plan. If the podcast has helped you to live better with type 1 please tell someone else how to find the show and consider leaving a rating and review on Apple Podcasts. Thank you! The Juicebox Podcast is not a charitable organization.
Ozempic is being hailed as “the end of the Obesity Epidemic.” This week, Mike and Aubrey dig through the sensational claims. But will they make it past the caveats?Links: How a Canadian scientist and a venomous lizard helped pave the way for Ozempic The Discovery and Development of Liraglutide and Semaglutide Ozempic and Wegovy maker courts prominent Black leaders to get Medicare's favor Insurers clamping down on doctors who prescribe Ozempic for weight lossOzempic prescriptions can be easy to get online. Its popularity for weight loss is hurting those who need it most Glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: real-world evidence from a Mediterranean areaSemaglutide in Patients with Heart Failure with Preserved Ejection Fraction and ObesityReal-world weight change, adherence, and discontinuation among patients with type 2 diabetes initiating glucagon-like peptide-1 receptor agonists in the UKSafety of SemaglutideSemaglutide for the treatment of overweight and obesity: A reviewOnce-Weekly Semaglutide in Adolescents with ObesitySemaglutide 2.4 mg for the Treatment of Obesity: Key Elements of the STEP Trials 1 to 5Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary DiseasesReal-World Adherence and Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists Therapy in Type 2 Diabetes Mellitus Patients in the United StatesMedications and conditions associated with weight loss in patients prescribed semaglutide based on real-world dataThanks to Doctor Dreamchip for our lovely theme song!Support the show
© 2020-2025 Ivy Podcast Discovery LLC
