Podcasts about Exploratory

Featuring a slide presentation and related discussion from Dr Adrienne G Waks, including the following topics: Updated analyses from key studies of the 21-gene Recurrence Score® for localized ER-positive breast cancer (29:30) Four-year landmark analysis of the NATALEE trial of adjuvant ribociclib with nonsteroidal aromatase inhibitor for localized breast cancer (9:49) The PADMA trial of palbociclib with endocrine therapy compared to chemotherapy induction followed by endocrine therapy maintenance for hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (mBC) (11:25) Imlunestrant with or without abemaciclib for metastatic ER-positive mBC (13:18) TROP2-directed antibody-drug conjugates (ADCs) datopotamab deruxtecan and sacituzumab tirumotecan for HR-positive/HER2-negative mBC (17:50) Recent analyses from the DESTINY-Breast06 trial of trastuzumab deruxtecan (T-DXd) after endocrine therapy for HR-positive, HER2-low or HER2-ultralow mBC (21:09) The ICARUS-BREAST01 Phase II trial of the HER3-targeted ADC patritumab deruxtecan for HR-positive/HER2-negative mBC (26:02) Updates from neoadjuvant/adjuvant trials of pembrolizumab (KEYNOTE-522) and atezolizumab (NSABP B-59/GBG 96-GeparDouze) for localized triple-negative breast cancer (TNBC) (27:36) Ten-year update of the OlympiA trial of adjuvant olaparib for patients with germline BRCA1/2-mutated HER2-negative localized breast cancer (31:23) Exploratory analysis of patients who did or did not receive prior PD-1/PD-L1 inhibition in the Phase III OptiTROP-Breast01 study of sacituzumab tirumotecan versus chemotherapy for previously treated advanced TNBC (32:56) CNS efficacy of T-DXd (DESTINY-Breast12 trial) and outcomes with palbociclib combined with anti-HER2 therapy (AFT-38 PATINA trial) for HER2-positive mBC (34:04) CME information and select publications

 In this JCO Article Insights episode, Lauren Shih summaries "Longitudinal Results From the Nationwide Just ASK Initiative to Promote Routine Smoking Assessment in American College of Surgeons–Accredited Cancer Programs" by  Jessica L. Burris, et al published November 19, 2024. Come back for the next episode where JCO After Hours host, Dr. Davide Soldato interviews the author of the JCO article discussed, Dr. Jessica Burris. TRANSCRIPT Lauren Shih: Hello and welcome to JCO Article Insights. I'm your host Lauren Shih, and today we will be discussing the article, “Longitudinal Results From the Nationwide Just ASK Initiative to Promote Routine Smoking Assessment in American College of Surgeons–Accredited Cancer Programs” by Dr. Jessica Burris and colleagues published in the March issue of JCO. This study reports the finding of the Just ASK Initiative, an effort aimed at improving universal smoking assessment in cancer programs nationwide. We know that smoking after a cancer diagnosis is associated with numerous negative outcomes including worse survival, increased treatment related complications, poorer quality of life and higher healthcare costs. Patients who smoke are also at increased risk for cancer recurrence and second primary malignancies. Despite these risks, data show that a significant number of patients with newly diagnosed cancer still smoke and around 15% of cancer survivors continue smoking. Recognizing this discrepancy, national oncology organizations strongly recommend routine smoking assessment and cessation support as part of standard cancer care. However, despite these guidelines, smoking assessment and cessation assistance remain inconsistent across oncology practices. Surveys show that most National Cancer Institute designated cancer centers have insufficient resources to effectively support smoking cessation efforts. To address this gap, several large scale initiatives have been launched, including efforts by the National Cancer Institute, the Canadian Partnership Against Cancer, and the American College of Surgeons. The largest of these initiatives, through the American College of Surgeons, is the subject of our report today. In 2022, the American College of Surgeons introduced the Just ASK Quality Improvement Program with the goal of increasing routine smoking assessment. As member institutions, accredited programs are required to complete at least one quality improvement program annually. And in 2022, 40% of programs chose to participate in Just ASK. The primary goal of this quality improvement program was to ask at least 90% of newly diagnosed cancer patients about their smoking status. Offering smoking cessation support was encouraged, but not a mandatory component or primary endpoint for the initiative. To implement Just ASK, participating programs used a well-established Plan-Do-Study-Act methodology which is a structured, iterative approach for improving healthcare processes. Programs used local quality improvement teams and resources for implementation and had access to online training, educational webinars, and technical resources to help integrate smoking assessment into routine care. Programs completed three surveys: a baseline survey reflecting smoking assessment practices in the year before Just ASK; a midpoint survey after six months of participation; and a final survey after one year in the program. The surveys assess program characteristics, barriers to smoking assessment, readiness to change, and the frequency of smoking related clinical practices such as asking about smoking, documenting smoking status, and advising smoking cessation. Programs reported on implementation strategies they adopted to improve smoking assessment. Finally, programs reported the number of newly diagnosed cancer patients they saw, how many were asked about their smoking status and how many were identified as current smokers during each reporting period. Results from 762 participating cancer center programs were analyzed. The programs represented a diverse mix of practice sites with over 50% identified as community based. Retention in the program was high, with nearly 90% of programs completing the final survey. Most programs reported moderate organizational readiness at baseline along with an average of 4.6 implementation barriers to conducting routine smoking assessment. Barriers included factors such as lack of time, competing clinical priorities, and lack of designated tobacco treatment specialists. At baseline, the ask rate was 87.8% and this increased to 91.9% at the final survey, meeting the previously identified goal for the initiative. Throughout the initiative, programs reported increases over time in assessing smoking status, in advising patients who smoked and quit, and in documenting these assessments and recommendations in the medical record. Importantly, the smoking rate among patients asked ranged from 18.5% to 19.8% across the three surveys, demonstrating a high rate of current smoking among newly diagnosed cancer patients. The most common implementation strategies adopted by programs to promote change included gaining leadership support, improving documentation on the electronic health record, and training staff and providers. There were no major differences in implementation strategies based on program type. Organizational readiness was positively associated with better smoking assessment practices, and implementation barriers had a negative impact, although not always statistically significant. The number of implementation strategies used by programs showed a positive, significant association with smoking assessment practices at the final survey. Exploratory analyses did not suggest that program type or patient volume had a consistent relationship with the outcomes. Although the primary goal of Just ASK was smoking assessment and not cessation assistance or intervention, programs did report on cessation related practices. For example, programs reported providing education or self-help materials increased from 26% to 48%, referrals to tobacco treatment specialists increased from 25% to 35%, and referrals to quit lines increased from 27% to 45%. Prescribing or recommending FDA approved cessation medications increased from 17% to 21%. In conclusion, Just ASK is the largest nationwide initiative to standardize and improve smoking assessment in cancer care. It successfully improves smoking assessment across a diverse range of cancer practices, ensuring that hundreds of thousands of newly diagnosed cancer patients were asked about their smoking status. As nearly 20% of the cohort reported smoking, this represents a critical first step in helping patients access smoking cessation resources. Participating programs demonstrated small but sustained practice changes in smoking assessment, meeting the a priori determined goal of a 90% ask rate. However, as a quality improvement initiative, Just ASK was not designed as a clinical trial, so conclusions regarding the efficacy of the program as an intervention are limited. Selection bias may have also played a role in the findings as program participation was voluntary. Additionally, the initiative lasted just one year and while the initial improvements were steady during that time, the long term impacts of Just ASK on smoking assessment remain uncertain. Looking ahead, the American College of Surgeons recently completed the Beyond ASK initiative. This initiative is designed to go a step further and focuses on improving smoking cessation assistance and we await the results. The Just ASK initiative demonstrates the routine smoking assessment is feasible to complete as routine cancer care. This assessment is essential as identifying patients that smoke is the first and critical step towards offering smoking cessation support, which in turn can improve health outcomes and reduce cancer treatment costs. While Just ASK was a success in increasing assessment, the challenge now is ensuring that smoking cessation support is readily available for all patients who need it. Thank you for listening to JCO Article Insights. Please give us a rating or review and subscribe so you never miss a JCO episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.  

Shari talks with Zach Weber about his career as a multidisciplinary and mixed-media artist. Zach is 27 years old and has exhibited in institutions such as Art Miami, 2022, the Zolla/Lieberman ...

Do you want more active engagement in your classroom?  Today's episode is an audio version of my training titled “3 Simple Strategies To Foster Engagement, Play & Communication In Autistic Preschoolers”. The training covers transforming dumping & throwing toys into structured play-based activities, the importance of following a child's interests, the need for flexibility in teaching approaches, and integrating augmentative and alternative communication (AAC) into play-based learning. The session aims to empower educators and parents with actionable insights to support young autistic children effectively.  Keep listening to learn more! Takeaways ●     Ideas for transforming dumping and throwing behaviors into structured play activities ●     Exploratory play is a natural part of development for all children, including autistic children ●     Following a child's lead means observing their interests and engaging with them at their level ●     Identifying deep interests can significantly enhance engagement and learning ●     Flexibility in teaching allows for real-time adjustments to meet children's needs ●     Integrating AAC into play creates a low-pressure environment for communication ●     Modeling language without expectation fosters confidence in using AAC ●     Play should be fun, reciprocal, and pressure-free to encourage natural exchanges ●     Using children's interests in lesson plans can make learning more meaningful ●     Building trust through play is crucial for developing relationships with autistic children  Links 3 Simple Strategies Handout: https://drive.google.com/file/d/1q2MIOQ9Hn5TZBVEAnYQQOdzDBqw7uNj2/view?usp=sharing Watch the YouTube version with slides showing the concepts: https://youtu.be/Y9Z1Ok-f84U Themed play visual supports: https://www.teacherspayteachers.com/Product/Autism-Play-Themed-Visual-Supports-For-Special-Education-8414926  Put-In Activity Challenge: https://autismlittlelearners.thrivecart.com/put-in-challenge-2024/  You may also be interested in these supports: 1.    Visual Support Starter Set 2.    Visual Supports Facebook Group 3.    Autism Little Learners on Instagram 4.    Autism Little Learners on Facebook

IN HOC PROGRAMMA’ ‘DE WHEELOCK 6th , Ed. capite tertio, paginis 17-23: de nominibus et adiectivis omnibus casibus ex secunda declinatione, de appositione, et de verborum ordine in oratione vel sententia’ ‘SEQUIMUR’ [QUIA “NUNTII IN LINGUA LATINA” ‘INSTRUMENTUM’ ‘AD LATINUM DISCENDUM ET DOCENDUMQUE’ ‘EST’]. ‘NUNTII IN LINGUA LATINA’ ‘IN LINGUA LATINA, ANGLICA ET GALLICA’ ‘*AUDIS’! CIVITATES FOEDERATAE AMERICAE ET RUSSIA CONTRA EUROPAM ET UCRAINAM. 14 TRANSLATIO A FERNANDA SOLÍS VERSAM EST. ‘*CIVITATES FOEDERATAE AMERICAE ET *RUSSIA ‘COLLOQUIA’ ‘DE UCRANIA’ , ‘SINE KIOVIA NEQUE UNIONE EUROPAEA ‘*INEUNT’ . // ‘*EUROPA PERTURBATA ‘*EST’ ‘QUIA DEFENSIONEM SUAM SINE AMERICA ‘COGITARE’ ‘INDIGET’ . AEGYPTO. TRANSLATIO AB ALISSA SOUZA VERSAM EST. ‘*CAIRUS’ ‘SUUM CONSILIUM’ ‘PRO GAZA’ ‘*PARAT’. // ‘*NATIONES ARABICAE’ ‘SUAS OPTIONES’ ‘IMPROVISO IMPETU’ ‘A DONALDO TRUMP, CIVITATUM FOEDERATAE AMERICAE PRAESIDE,’ ‘CAPTAE’ ‘*PRAEPARANT’. //. ‘*AEGYPTUS’ ‘CONSILIUM’ ‘DE REFICIENDO HOC TERRITORIO PALAESTINENSI’ ‘CUM ARGENTARIA MUNDANA’ ‘*EXCOLIT’. {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿Quot nomina et adiectiva in secunda declinatione invenis, quae sunt? ¿1 vel plures appositionem invenis? ¿Verborum ordo in orationes vel sententias adaequatus est? ¿Lexico ex capite 3 invenis?}. ‘NUNTII IN LINGUA LATINA’ ‘IN LINGUA LATINA, ANGLICA ET ITALICA’ ‘*AUDIS’! CIVITAITS VATICANAE STATU. ‘PAPA *FRANCISCUS’ ‘IN VALETUDINARIO’ ‘AD ANALYSES FACENDUM’ ‘*EST’ . // ‘*FRANCISCUS, PAPA ECCLESIAE CATHOLICAE ROMANAE 15 A TERTIO DECIMO DIE MARTIIS MENSE ANNO DOMINI BIS MILLÉSIMO DECIMO TERTIO,’ ‘IN VALETUDINARIO’ ‘*MANET’ [QUIA ‘ANALYSES’ ‘MORBOS MULTIPLICES’ ‘*OSTENDUNT’]. {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿Quot nomina et adiectiva in secunda declinatione invenis, quae sunt? ¿1 vel plures appositionem invenis? ¿Verborum ordo in orationes vel sententias adaequatus est? ¿Lexico ex capite 3 invenis?}. ‘NUNTII IN LINGUA LATINA’ ‘IN LINGUA LATINA, ANGLICA ET GERMANICA ‘*AUDIS’! TRANSLATIO AB ALISSA SOUZA VERSAM EST. UCRAINA. BELLATOR SOLITARIUS. // [CUM ‘*RUSSIA’ ‘URAINAM’ ‘*INVADEBAT’], ‘*VLADIMIRUS ZELENS’KYJ, UCRAINAE PRAESES’ ‘BELLUM DOMINATOR’ ET , ‘QUOMODO WINSTON CHURCHILL’ ‘PUTATUS EST’. // ‘ID EST: FORTIS ET FIRMUS’ . // ‘NUNC VERO’ ‘DONALDUS , TRUMP, DENUO CIVITATUM FOEDERATAE AMERICAE PRAESES’ , ‘EUM’ ‘RELIQUIT’. // ‘*ZELENS’KYJ’ ‘IPSE SIT’ ‘IAM *NESCIT’ . {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿Quot nomina et adiectiva in secunda declinatione invenis, quae sunt? ¿1 vel 2 appositiones invenis, quae sunt? ¿Verborum ordo in orationes vel sententias adaequatus est? ¿Lexico ex capite 3 invenis?}. 16 IN ORBE TERRARUM. ‘*AGE’, ‘ORBEM TERRARUM’ ‘*DIVIDAMUS’. // ‘FOEDUS’ INTER ‘TRUMP, ITERUM C-F-A PRAESES A DIE VICESIMO MENSE IANUARII HOC ANNO’ , ET ‘PUTIN, ITERUM FOEDERATIONIS RUSSICAE PRAESES A ANNO BIS MILLESIMO DUOCESIMO’ , UCRAINAM AESTUAT ET SOCIA CONCUTIT. // ¿‘INTER EOSNE’ ‘EUROPAE PACEM ET FUTURUM’ ‘*DECIDENT’? {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿Nomina et adiectiva in secunda declinatione invenis? ¿2 appositiones invenis, quae sunt? ¿Verborum ordo in orationes vel sententias adaequatus est? ¿Lexico ex capite 3 invenis?}. ‘NUNTII IN LINGUA LATINA’ ‘IN LINGUA LATINA, ANGLICA ET HISPANICA’ ‘*AUDIS’! MEXICO. MEXICOPOLIS. ‘AEROPLANA NON GUBERNATA SPECULATORIAS. // ‘TRUMP *REGIMEN’ ‘SEDIS CENTRALIS EXPLORATORIAE’ ‘AEROPLANA NON GUBERNATA SPECULATORIAS, ID EST , VEL VEHICULUM AERIUM EXPLORANS SINE GUBERNATOR, ’ ‘AD NARCOTICORUM CULINAS IN MEXICO INVENIENDUM’ ‘*UTUNTUR’. {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿Quot nomina et adiectiva in secunda declinatione invenis? ¿1 appositiones invenis, quae 17 sunt? ¿Verborum ordo in orationes vel sententias adaequatus est? ¿Lexico ex capite 3 invenis?}. ‘NUNTII IN LINGUA LATINA’ ‘IN LINGUA LATINA, ANGLICA ET RUSSICA’ ‘AUDIS’! TRANSLATIONES A SAID RAYMUNDO DELGADO VERSA SUNT. TRUMP ADVERSUS ZELENSKY. '*TRUMP' 'APROBATIONEM ZELENSKII' 'AD QUATTUOR PARTES EX CENTUM CECIDIT' '*DIXIT'. // 'ESTNE HOC VERUM?' // '*ORATIO DONALD TRUMP' 'ERGA UCRANIAM ET ERGA VOLODYMYR ZELESNKY, UCRAINAE PRAESES,' MAGIS HOSTILIS' '*FIT'. // '*TRUMP, DUX CIVITATIUM FOEDERATAE AMERICAE,' 'DIE DUODEVIGINTI FEBRUARII MENSE' '*ITERAVIT': 'SECUNDUM SUA SENTENTIAM', '*ELECTIONES PRAESIDENCIALES' 'IN UCRANIA IN MOMENTO FUTURO PROXIMO' '*HABENDAE ESSE'. // 'SECUNDUM TRUMP': ('HOC DICERE' '*NON PLACET') '*VALOR APROBATIONIS ZELENSKY' QUTUOR PARTES EX CENTUM TANTUM' '*EST'. {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿1 vel plures appositionem invenis? ¿Verborum ordo in orationes vel sententias adaequatus est?}. DENUO TRUMP ADVERSUS ZELENSKY. -"*EGO' 'STATUM' 'VENDERE NON *POSSUM."- // '*ZELENSKY' ['CUR PROPOSITIONEM CIVITATIUM 18 FOEDERATAE AMERICAE' 'DE OPIBUS MINERALIBUS' '*REIECIT']' *EXPLICAVIT'. // ET '*ZELENSKY' 'AD TRUMP', ['*QUI' 'ELECTIONES' 'IN UCRANIA' ' *PETIVIT']' *RESPONDIT'. // -"SI '*ALIQUIS' 'ME MUTARE' 'HOC TEMPORE' '*VULT', TUNC: ['*HOC' '*NON EFFICIET']. // PRAETEREA '*CORRUPTIO INFORMATIONIS' 'DE CASU VALORIS APROBATIONIS' 'A RUSIA' '*PROVENIT'.- // '*ADMINISTRATIO TRUMP' 'SUAM ATTITUDINEM ERGA RUSSIAM' '*LENIVIT'. // 'BELLUM '*NON APELLAT', SED 'CONTENTIONEM'. ‘NUNTII IN LINGUA LATINA’ ‘IN LINGUA LATINA, ANGLICA ET SINENSIS PINYIN’ ‘*AUDIS’! TRANSLATIONES A CASANDRA FREIRE VERSA SUNT. SINIS. ‘DIE QUATTUORDECIM FEBRUARII’ ‘*COLLOQUIUM’ ‘SUCHEI ANNI BIS MILLESIMO VICESIMO QUINTO’ ‘PROMOTIONIS PROGRESSIONIS ET INNOVATIONIS INTELLIGENTIAE ARTIFICIALIS’ ET ‘*COLLOQUIUM’ ‘POTESTATIS NOVAE INDUSTRIALIZATIONIS ARTIFICIALIS INTELLIGENTIAE’ ‘*EVENERANT’ . // ‘IN THEMATE’ ‘*TRACTANDO’ "*INTELLEGENTIA ARTIFICIALIS’ ET ‘BONA *QUALITAS’ ‘NOVUM FUTURUM’ ‘*DUCIT", ‘PLUS QUAM CENTUM’ ‘*EXEMPLA’ ‘[UT ROBOTA HUMANOIDES, [ID EST ROBOTUM CORPUS SIMILIS HOMINI], RATIONES MODERATORUM 19 INTELLIGENTIUM] ET ‘* EXEMPLARIA VIRTUALIUM INTERACTIVORUM’ [CUM MAGNA-SCALAE INTERACTIVA AI, [ ID EST INTELLEGENTIA ARTIFICIALIS]] ‘*REVELATI SUNT’ . {De Wheelock 6th Ed. Capite 2, ¿Nomen ex prima declinatione invenis quod quadruplex apparet?}. SINIS. ‘NOVAE INCLINATIONES, NOVA LOCA, NOVAE POTENTIAE’: ‘NOVI *MERCATUS’ ‘NOVUM VIGOREM OECONOMIAE SINENSIS ‘*DEMONSTRANT’ . // ‘PRIMO VER ‘*FESTO’ , [HOC DECLARANTE MUNDI HEREDITATIS] ‘*IUCUNDIUS EST’ ET ‘*MERCATUS NOVI ANNI’ ‘IN FLUMINE MERIDIANO’ ‘*VIVIDISSIMUM EST’. {De Wheelock 6th Ed. Capite 3, Paginis 17-23. In hoc nuntio inveni: ¿Quot nomina et adiectiva in secunda declinatione invenis, quae sunt? ¿Aliqua appositio invenis, quae est? ¿Verborum ordo in orationes vel sententias adaequatus est? ¿Lexico ex capite 3 invenis?}. LEXICON LEXICON EX “CIVITATES FOEDERATAE AMERICAE ET RUSSIA CONTRA EUROPAM ET UCRAINAM”… Nomina • America – America • Colloquia – Talks, negotiations • Civitates – States • Defensionem – Defense • Europa – Europe 20 • Foederatae – Allied (as a substantive: Allied States) • Kiovia – Kyiv • Russia – Russia • Unione – Union • Ucrania – Ukraine Adiectiva • Perturbata – Disturbed, troubled Verba • Cogito – I think, consider • Indigeo – I need, lack • Ineo – I enter, begin • Sum – I am LEXICON EX “AEGYPTO”… Nomina • Aegyptus – Egypt • Argentaria – Bank • Cairus – Cairo • Civitatum (genitivo plural de Civitas) – States • Consilium – Plan, decision • Foederatae – Allied (as a substantive: Allied States) • Gaza – Gaza • Impetu (ablativo de Impetus) – Attack, momentum • Mundana – World (as an adjective meaning "global") • Nationes – Nations • Optiones – Options, choices • Palaestinensi – Palestinian (adjective) • Praeses – President • Territorium – Territory Adiectiva 21 • Arabicae – Arabic • Captae – Captured, seized • Suas – Their own • Suum – Their own Verba • Excolo – I develop, cultivate • Paro – I prepare • Praeparo – I make ready, prepare LEXICON EX “CIVITAITS VATICANAE STATU”… Nomina • Analyses – Examinations, tests • Ecclesia – Church • Franciscus – Francis • Menses – Month • Morbos (acusativo plural de Morbus) – Diseases • Papa – Pope • Valetudinarium – Hospital Adiectiva • Catholica – Catholic • Multiplices – Multiple • Romana – Roman • Tertius – Third Verba • Maneo – I remain, stay • Ostendo – I show, reveal • Sum – I am LEXICON EX “UCRAINA”… Nomina • Bellator – Warrior • Bellum – War • Civitates – States 22 • Dominator – Ruler, master • Praeses – President • Russia – Russia • Ucraina – Ukraine • Zelens’kyj – Zelensky Adiectiva • Firmus – Strong, firm • Fortis – Brave, courageous • Solitarus – Lonely, solitary Verba • Nescio – I do not know • Sum – I am LEXICON EX “IN ORBE TERRARUM”… Nomina • Foederatio – Federation • Foedus – Treaty, alliance • Futurum – Future • Orbis – World, globe • Pax – Peace • Praeses – President • Russia – Russia • Socia – Ally • Ucraina – Ukraine Adiectiva • Russica – Russian Verba • Aestuo – I am in turmoil, I am agitated • Decido – I decide • Divido – I divide • Concutio – I shake, I disturb LEXICON EX “MEXICO”… Nomina • Aeroplanum – Airplane 23 • Culina – Kitchen (in this context: drug lab) • Mexico – Mexico • Regimen – Government • Sedes – Headquarters, seat • Vehiculum – Vehicle Adiectiva • Centralis – Central • Exploratorius – Exploratory, reconnaissance • Speculatorius – Surveillance, spy Verba • Invenio – I find, discover • Utor – I use (takes the ablative) LEXICON EX “TRUMP ADVERSUS ZELENSKY.”… Nomina • Aprobatio – Approval • Civitates – States • Dux – Leader • Electiones – Elections • Mensis – Month • Oratio – Speech, discourse • Praeses – President • Sententia – Opinion, judgment • Ucraina – Ukraine • Valor – Value Adiectiva • Foederatus – Allied • Futurus – Future • Hostilis – Hostile • Presidentialis – Presidential • Proximus – Near, close Verba • Dico – I say, speak • Fio – I become, happen 24 • Habeo – I have • Itero – I repeat • Placeo – I please, am agreeable • Sum – I am LEXICON EX “DENUO TRUMP ADVERSUS ZELENSKY.” Nomina • Administratio – Administration • Aprobatio – Approval • Bellum – War • Civitas – State • Contencio – Conflict, dispute • Corruptio – Corruption • Electio – Election • Informacio – Information • Minerale – Mineral • Opes – Resources, wealth • Russia – Russia • Status – State, condition • Valor – Value Adiectiva • Foederatus – Allied • Hoc – This • Suus – His, their own Verba • ApeIlo – I call, name • Efficio – I accomplish, achieve • Explico – I explain • Lenio – I soften, alleviate • Possum – I am able, I can • Provenio – I come forth, arise • Reicio – I reject • Respondeo – I reply, answer • Vendo – I sell 25 • Volo – I want, wish LEXICON EX “SINIS” … Nomina • Colloquium – Conference, discussion • Dies – Day • Exemplum – Example • Futurum – Future • Innovatio – Innovation • Intelligentia – Intelligence • Potestas – Power • Progressio – Progress • Promotio – Promotion • Qualitas – Quality • Ratio – System, method • Robotum – Robot • Themata – Theme, subject Adiectiva • Artificialis – Artificial • Humaniformis – Humanoid • Industrialis – Industrial • Interactivus – Interactive • Novus – New Verba • Duceo – I lead • Revelo – I reveal • Tracto – I handle, discuss LEXICON EX “SINIS” … Nomina • Economia – Economy • Flumen – River, stream • Hereditas – Heritage, inheritance • Mercatus – Market 26 • Mundi – World (genitive singular of Mundus) • Potentia – Power, potential • Vigor – Strength, vigor • Ver – Spring (season) Adiectiva • Novus – New • Sinensis – Chinese • Iucundus – Pleasant, enjoyable • Vividissimus – Very vivid, most vivid Verba • Demonstrato – I demonstrate • Vivo – I live SI NUNTII IN LINGUA LATINA TRADUCTOR ESSE VOLUERIS, QUAESO LITTERAM ELECTRONICAM AD lpesquera@up.edu.mx MITTAS’. If you would like to collaborate as a translator in Nuntii in Lingua Latina, please send an email to lpesquera@up.edu.mx

Send us a textIn the second installment of our deep dive into Therapy First and Gender Exploratory Therapy, hosts Juniper and Laurel, both licensed clinicians, expose the growing network of anti-trans organizations operating under the guise of “evidence-based” care.We break down the interconnected web of groups like GenSpec, the Society for Evidence-Based Gender Medicine (SEGM), and Our Duty, uncovering their ties to conversion therapy, pseudoscience, and policy-driven misinformation. From their influence on anti-LGBTQ legislation to their claims about gender dysphoria treatment, we separate fact from fearmongering.

New Britain Mayor Erin Stewart says she's exploring a run for Governor of Connecticut. New Haven officials will relaunch a plan to improve connectivity on I-91. New York's AG has sued a developer for allegedly building on protected land in the Pine Barrens. New York lawmakers push for a pay raise for restaurant workers. Plus, Democrats are concerned about the White House's freeze of federal grants and loans.

In this JCO Article Insights episode, Ece Cali summarizes findings from the JCO article, "Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study." TRANSCRIPT Ece Cali: Hello and welcome to the JCO Article Insights. I'm your host Ece Cali and today we will be discussing the Journal of Clinical Oncology article the “Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III TROPION-Lung01 Study.”  Despite significant advances in non-small cell lung cancer treatment over the past decades, second line treatment options for non-small cell lung cancer without actionable genomic alterations have remained largely unchanged since 2000. Many clinical trials failed to demonstrate improved overall survival compared to docetaxel based regimens. TROPION-Lung01 is a global open label randomized phase 3 trial comparing the efficacy and safety of Dato-DXd to docetaxel in patients with previously treated advanced or metastatic non-small cell lung cancer. Dato-DXd is an antibody drug conjugate targeting TROP2 and delivering deruxtecan, a DNA topoisomerase 1 inhibitor, as its payload. The trial is designed with dual primary endpoints of progression free survival, as assessed by blinded independent central review, and overall survival. The initial PFS results were presented at ESMO in 2023 and this article reports more detailed data and overall survival analysis of the trial.   In the TROPION-Lung01, 299 patients were randomly assigned to receive Dato-DXd and 305 patients to receive docetaxel. Patients were stratified by the presence of actionable genomic alterations, histology, treatment with PD-1/PD-L1 immunotherapy as the last line of therapy, and geographical region. The baseline characteristics of the patient population were overall balanced between the treatment arms. I'd like to highlight a couple of key points here. The median age was 63 years in the Dato-DXd and 64 years in the docetaxel arm. Similar to the many clinical trials in the thoracic oncology field, this is younger than the median age of lung cancer diagnosis in the US, which is around 70. African American and Hispanic patients were underrepresented in this trial with 41% of patients identifying themselves as white and 39% as Asian. The Ddocetaxel arm had a slightly higher percentage of male patients, 69% versus 61%. The majority of the trial population, 73%, had adenocarcinoma. Patients with actionable genomic alterations were included in this trial if they received one or more targeted therapy and platinum based chemotherapy prior to the enrollment. 17% of the trial population had an actionable genomic alteration in this trial.  When it comes to the efficacy results in the full analysis set, the PFS improvement was statistically significant. The median PFS was reported as 4.4 months for the Dato-DXd, and 3.7 months for the docetaxel arm with the hazard ratio of 0.75 and a P value of 0.004. However, after a median follow up of 23 months, the trial did not meet its primary endpoint of overall survival. The median overall survival was 12.9 months for patients treated with Dato-DXd and 11.8 months for patients treated with docetaxel with the hazard ratio of 0.94 and a P value of 0.53. Objective response was a secondary endpoint and the confirmed objective response rate was 26% with Dato-DXd, and 13% with docetaxel.  Now let's take a closer look at some of the subgroup analyses. Exploratory analyses of key subgroups in TROPION-Lung01 demonstrated differences in efficacy based on histology. In the nonsquamous subgroup, Dato-DXd showed a longer progression free survival of 5.5 months compared to 3.6 months with docetaxel with a hazard ratio of 0.84. However, in the squamous subgroup, Dato-DXd performed worse with a progression free survival of 2.8 months compared to 3.9 months with docetaxel corresponding to a hazard ratio of 1.32. A similar trend was observed in the overall survival analyses, though confidence intervals crossed 1 in both histology subsets, in this case, the differences observed were not statistically significant. In the nonsquamous subset, the median overall survival was 14.6 months with Dato-DXd and 12.3 months with docetaxel with a hazard ratio of 0.84. In the squamous subset, both arms had shorter survival compared to the nonsquamous subset. The median overall survival with Dato-DXd was almost two months shorter, so 7.6 months, compared to 9.6 months with docetaxel corresponding to a hazard ratio of 1.32. While these analyses suggest the potential survival benefit for Dato-DXd in nonsquamous subset, this trial was not powered to test this hypothesis hence these analyses remain exploratory. Another subgroup analysis of note was the group with actionable genomic alterations. Patients with actionable genomic alterations achieved a median PFS of 5.7 months with Dato-DXD and 2.6 months with docetaxel corresponding to a hazard ratio of 0.35. Similarly, the median overall survival was longer in patients with actionable genomic alterations by almost six months, with a median overall survival of 15.6 months with Dato-DXd and 9.8 months with docetaxel corresponding to a hazard ratio of 0.65.  Now, let's talk about safety. Grade 3 or higher treatment related adverse events occurred in 26% of patients with Dato-DXd and 42% with docetaxel. The most common adverse event of any grade seen in the Dato-DXd arm were stomatitis seen in 47% of patients, nausea in 34%, and alopecia in 32%. Treatment related interstitial lung disease occurred in 8.8% of patients on Dato-DXd and 4.1% of patients on docetaxel. Of note, grade 5 drug related ILD was more frequent with Dato-DXd. Seven patients on Dato-DXd and one patient on docetaxel died secondary to drug related ILD in this trial.  In summary, TROPION-Lung01 aims to address an unmet need for patients with previously treated non-small cell lung cancer. For this population, the treatment options remain limited with poor survival outcomes. TROPION-Lung01 is a positive trial by design due to clinically modest improvement in PFS. However, the lack of overall survival improvement is disappointing. Exploratory subgroup analyses suggest Dato-DXd may offer survival advantage in specific subsets such as nonsquamous non-small cell lung cancer and patients with actionable genomic alterations. However, these findings require further validation in a prospective trial since TROPION-Lung01 was not designed to address these questions. The data from this trial alone is not sufficient to argue for a change in clinical practice. However, it informs how the future trials using this drug should be tailored. This highlights the importance of studying potential predictive biomarkers earlier in the drug development and incorporating these biomarkers prospectively into the clinical trial designs.  Due to the lack of overall survival benefit in this trial, the biologic license application for accelerated approval of Dato-DXd for patients with previously treated nonsquamous non-small cell lung cancer was voluntarily withdrawn. New BLA was submitted for Dato-DXd for patients with previously treated advanced EGFR positive non-small cell lung cancer. This BLA is based on data from TROPION-Lung05, TROPION-Lung01 and TROPION-PanTumor01. Of note, the results of TROPION-Lung05 trial have been just published in JCO.   This wraps up today's episode. Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries and be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.    

Send us a textWelcome Back to Headfirst: A Concussion Podcast, Today, we have Dr. Joe Warne who is a leading authority in sports science, biomechanics, and physiology, specializing in the biomechanics of running and the role of footwear. With a wealth of hands-on experience in Strength and Conditioning, Dr. Warne has worked with elite athletes and teams, also serving as a high-performance coach and sports science consultant. Holding a PhD, his ground-breaking research has positioned him as a foremost expert on how footwear affects athletic performance and injury prevention. He has published extensively on these topics and delivered keynote addresses at major international conferences. Currently, Dr. Warne is a lecturer at Technological University Dublin, where he teaches research methods and sports science, and also directs the university's Sports Science Replication Center. Renowned for his rigorous, critical approach to research integrity, he brings this expertise to the topic of today's discussion.  -          How Dr Warne Come into The Field of Research (01:20)-          Running and Super Shoes (03:15)-          Research Methods, Philosophy and Critical Appraisal (4:40)-          Exploratory & Confirmatory Research: Using Concussion as an Example (7:00)-          Scientific Culture (08:34)-          Sample Sizes in Research (12:08)-          P Hacking (16:17)-          Andrew Wakefield Example and Claims in Research (18:40)-          Learning Process in Research and Peer Review Credibility (23:57)-          Scoop Creep and Reviewing Process (29:00)-          Research Units in Higher Education (30:30)-          Assessing an Article (35:10)-          When to extrapolate the research (38:00)-          Dr Joe Warnes Vison and How to Support His Work (43:00)  Sports Science Replication Centre: https://ssreplicationcentre.com/author/joe-warne/ Twitter/X: @joeWarne1  Google Scholar: https://scholar.google.com/citations?user=jWwlBl4AAAAJ&hl=en

As party attempts to complete their exploration of The Earthenwoven Lilac, they stumble upon a discovery most intriguing.Beddlym's Social Hour contains adult language and adult situations. Listener discretion is advised.Credits:DM: BeddlymGrom: Percy SteeleTylylor: Kari DennisMirmulnir: GeorgeLenore: Marc McGrathFind all of our relevant links in our Link Tree.Support us on PatreonUse our affiliate code peaceinthechaos to receive $5.00 off Arkenforge's Master's Toolkit to start creating amazing VTT content.Produced by Peace in the Chaos ProductionsEmail: peaceinthechaosprod@yahoo.com or beddlym.gm@yahoo.comMusic by Monument Studios. Thanks to them for the great music and sound they're creating. Hosted on Acast. See acast.com/privacy for more information.

Hamilton Ulmer is working at the intersection of UI, Exploratory Data Analysis, and SQL at MotherDuck, and he's built a long career in EDA. Hamilton and Tristan dive deep into the history of exploratory data analysis. Even if you spend most of your time below the frontend layer of the stack, it is important to understand the trends in both the practice of data visualization  and the technologies that underlie that practice. For full show notes and to read 6+ years of back issues of the podcast's companion newsletter, head to https://roundup.getdbt.com. The Analytics Engineering Podcast is sponsored by dbt Labs.

To discuss this now, is Fianna Fáil TD Malcolm Byrne and People Before Profit Richard Boyd Barrett.

Send us a textSend us a textHey friends! In this quick update episode, Laurel drops in to share where she and Juniper are in the process of producing the gender exploratory therapy series (spoiler alert…it's a lot more of an in-depth and lengthy process than we anticipated!), and lets everyone know about CMH's winter break.Don't forget that our fundraiser for Advocates for Trans Equality is ongoing! See the links below to direct you straight to where you can purchase these merch items.We hope you have the end to 2024 that you most need, and we will see you in the new year! ✨

Send us a text‼️Content warning for sensitive discussions regarding the LGBTQ community. ⚠️What is Gender Exploratory Therapy, and why is it raising concern amongst therapists and LGBTQ+ advocates? In part 1 of our series, Juniper and Laurel, delve into Therapy First, the organization behind this controversial model. We examine its claims about "exploratory care", and gender-critical approaches, and discuss its implications for trans and gender-diverse communities.

While structured data elements such as patient identifier, medicine name and reaction, are fundamental for adverse event reporting, they may not capture all relevant details. This is where the narrative fields come in, allowing reporters to disclose important contextual information, such as the patient's full clinical course. But how do PV assessors interact with these narratives in spontaneous reports? What needs and challenges do they experience? These and other questions were addressed in an exploratory interview study by UMC researchers Joana Félix and Alem Zekarias.  Tune in to find out:What challenges are PV assessors faced with, when working with narratives? How could automation of certain tasks help streamline narrative analyses in the future?How can reporters craft narratives that effectively document adverse events? Want to know more?Pharmacovigilance assessors' experiences interacting with narrative fields in spontaneous reports: an exploratory interview study – poster presented at the 23rd ISoP Annual Meeting “Global Perspectives on Pharmacovigilance in the Digital Age and Advanced Therapeutics”, 1–5 October 2024 Montreal, Canada.Current Challenges in Pharmacovigilance: Pragmatic Approaches, by The Council for International Organisations of Medical Sciences (CIOMS). See page 133 on the role of narratives in good case management practices. Join the conversation on social mediaFollow us on X, LinkedIn, or Facebook and share your thoughts about the show with the hashtag #DrugSafetyMatters.Got a story to share?We're always looking for new content and interesting people to interview. If you have a great idea for a show, get in touch!About UMCRead more about Uppsala Monitoring Centre and how we work to advance medicines safety.

In a way, this could be titled “small win season” but the trick is figuring out where to best put your energy. We all have weaknesses but identifying them and investing time in the right place is the catch. Today, we look at different ways to make progress so you're not the same athlete next year as you were this season. Getting better doesn't always have to be hard. Put your energy in the right place. Topics: What is the Midwest? Fun way to break up the off season Athlete rebellion No man's land Create “identifying weeks” Investing time in the right place Performance anxiety Measuring where you are Exploratory training We should know our weaknesses The most crucial part of training Margin for error 10k a day in the pool Sometimes you're just gonna be stronger on one side High cadence vs. lower cadence and the middle ground “I hate Z2 work” Keep what's working ,ditch what's not Deficiencies Go hard on what you regret not going hard on every year Creating a great habit now Everything doesn't have to be hard Small win season   Mike Tarrolly - mike@c26triathlon.com Robbie Bruce - robbie@c26triathlon.com

Thu, 21 Nov 2024 07:00:00 +0000 https://talkingtransporttransformation.podigee.io/43-consuelo-araneda-diaz e23457cf75eac1528d578166a1475c4b In this episode, we explore the role of exploratory walks in urban spaces, a concept that connects mobility, discovery, and inclusive urban design. These walks, often overlooked in traditional mobility studies, highlight the value of experiencing a city on foot—uncovering hidden spaces and fostering a sense of connection with our surroundings. Through her work with La Reconquista Peatonal, Consuelo Araneda Díaz brings to light the walking experiences of Latin American women living in Berlin, emphasizing the unique perspective of walking as a way to engage with our communities. Our special guest, Consuelo Araneda Díaz, an architect and urban designer with a Master's Degree from the Technical University of Berlin, shares her insights on the potential of everyday walks to transform urban design, making our cities more inclusive and accessible for all. About La Reconquista Peatonal Links Mobility of Care: Introducing New Concepts in Urban Transport Many thanks to Our TUMI Partners: ADB, BMZ, C40 Cities, CAF, GIZ, ICLEI, ITDP, KfW, SLOCAT, UN-Habitat, WRI Our Guest: Consuelo Araneda Díaz LinkedIn Our Moderator Megi Natchkebia LinkedIn Max Bleß from audioBoutique for the sounddesign Sebastian Hofer from freifahrt for the concept and production support LINKS and INFORMATION about TUMI Twitter Facebook Youtube Website E-Mail: info@transformative-mobility.org 43 full no Transformative Urban Mobility Initiative

The Only Anime Podcast finally crack into the first handful of Fall Anime 2024 Season Anime Premiers, but only after a lengthy discussion of the future of weird looking dudes in anime games.UzumakiMetaphor: ReFantazioGhoul SchoolTying the Knot With an Amagami Sister

Today's podcast features Flynn Disney. Flynn is a parkour athlete and human performance coach known for integrating mind, body, and environment in movement training. Flynn combines his history as an athlete with an intensive study of human psychology and experience training animals to provide a unique and insightful perspective on training. All too often, training is thought of on the level of machine-like qualities. Sets, reps, drills, and coaching cues. Rarely do we consider those processes by which children and animals learn, or how the consideration of the total human can change the process by which we coach. Much of this also involves looking at what makes animals and humans both similar and unique, in their movement strength, and abilities. On today's show, Flynn digs into the key differences between animals and humans from a perspective of reflexes and internal wiring, the role of reflexes in training, and examples in plyometric, running, and dynamic “spinal-engine” activities (and the value of “the worm” breakdance move, from an athletic perspective). He talks about the role of attentional networks, and training implications, the impact of risk on our reflex loops in training, and more. Today's episode is brought to you by TeamBuildr's Gym Studio and Athletic Development Games. Use the code “justfly25” for 25% off any Lila Exogen wearable resistance training, including the popular Exogen Calf Sleeves. For this offer, head to: Lilateam.com TeamBuildr is an online software for coaches and trainers. Use the code “JUSTFLY” for a free 30-day trial of the TeamBuildr software. For a Gym Studio 14-day free trial, head to gymstudio.com View more podcast episodes at the podcast homepage. Main Points 9:00- Key differences between human and animal movement, particularly on the level of reflexes 18:00- Attentional aspects of the brain and training implications 24:00- The power of subconscious processes and the relaxation/reflex action in humans 30:00- Playing with varying frequencies in running and sprinting situations 35:00- “The Hero's Journey” of Coaching 50:00- The role and interplace of “Fixed” versus “Exploratory” aspects of training 59:00- Visual tracking and athletic human movements 1:10:00- Risk and reflex arcs in training Quotes “Animal movement is much more constrained by reflexes than human movement; if you take a rabbit and extend their back legs, their front leg will reflexively flex” “We (humans) have many more movement options (than animals)” “Taking small moments of rest (between main sets) is so profound that is so easy to implement; it seems to integrate learning at a deeper level, this cooling down process allowing new neural connections to form” “If you run with a more frequent step, instead of bounds or strides, it's such a different quality” “We're generally less happy when we are in (Default Mode Network) that state, we are more happy when we are task oriented, or sensory oriented” “When a reflex is terminated, it's very satisfying; when you move away from it, it feels dis-satisfying” “If I experience something that is possible, but not completely unimaginable, I will get a surge of energy” About Flynn Disney Flynn Disney is a professional parkour athlete and coach, known for his innovative approach to movement and skill development. Based in London, his mastery of parkour fundamentals, coupled with a deep understanding of biomechanics, has made him a sought-after coach in the movement training community. As a coach, Flynn emphasizes an approach the integrates mind and body, helping athletes of all levels break through physical and psychological barriers. Flynn also contributes to the sport through workshops and content that promote parkour as a tool for developing adaptable and well-rounded athletes.

WWE RAW was in Rip City, so what will we have to rip on this show? -What kind of car does CM Punk drive? -Where's the valet? -I'm prepared to die -Don't call him Butch. Seriously. -Woods doesn't want any help -Miz is no monster -Iron Hart vs Chris Kattan -Shannon Sharpe angle -Finn played match maker -Why is Breakker doing a good guy promo? -Walk him like a dog -Bianca Stamp -The end of the New Day? -What's next for the Wyatt Sicks? -Braun vs Bronson needs 10 ambulances -Monster's Ball? -Sami tries to wedge Gunther and Kaiser -Bianca lost? -Lucky Wade -What's Jey waiting for? Subscribe on patreon.com/LingusMafia for ad-free and video versions of the show, exclusive PPV/PLE reviews and bonus shows including every Wrestlemania, SummerSlam, Royal Rumble and Saturday Night's Main Event ever. Stay connected: All our social media (@LingusMafia) links can be found here: https://linktr.ee/lingusmafia Download the PrizePicks app today and use code CCN and get $50 instantly when you play $5! That's code CCN on PrizePicks to get $50 instantly when you play $5! You don't even need to win to receive the $50 bonus, it's guaranteed! "PrizePicks. Run Your Game!"

Do security tests and APIs leave you confused? Expert Bas Dijkstra makes API testing look easy and shares the essentials every dev ops professional needs to know.You'll learn how to spot and fix common API vulnerabilities, including sneaky JavaScript injections to the all-too-common broken object-level authorization. With hands-on demos and practical advice, you'll discover how to fortify your APIs against real-world threats. But that's not all—Bas also gives us a sneak peek into his upcoming contract testing course, perfect for anyone looking to master integration testing and ensure seamless API communication.❓What did you think of the show? Leave your anonymous feedback:https://forms.gle/Df5sDABiNMQn4YSj7CONNECT WITH BAS DIJKSTRA

August 28, 2024 ~ Former Detroit City Council president Saunteel Jenkins has launched an exploratory committee to consider a run to become the next mayor of Detroit. Guy, Lloyd, and Jamie talk with Jenkins about what her mayoral administration would focus on, while Mayor Mike Duggan has not announced his reelection plans.

In part one of Red Eye Radio with Gary McNamara and Eric Harley, sports personalities weigh in on current politics: Stephen A. Smith is now full #kaMAGA after he slams Harris for not doing a press conference, and Chris "Mad Dog" Russo goes off on a Trump tirade for the way he treated President Biden; Harris will suggest price controls for food in an upcoming speech; The late great economist Milton Friendman on inflation; Harris reportedly wants to distance the campaign from Bidenomics; Andrew McCarthy says Judge Merchan will sentence Trump to jail on September 10th; We need an explanation on why former Congresswoman Tulsi Gabbard is on a no fly list; Clueless Harris supporters are interviewed;  For more talk on the issues that matter to you, listen on radio stations across America Monday-Friday 12am-5am CT (1am-6am ET and 10pm-3am PT), download the RED EYE RADIO SHOW app, asking your smart speaker, or listening at RedEyeRadioShow.com Learn more about your ad choices. Visit podcastchoices.com/adchoices

Welcome back to our special Back to School series, where we're revisiting some of the most popular and impactful episodes to help you gear up for the new school year. These episodes have resonated with so many educators and parents, and we're excited to share them with you again. Let's dive into the first one! As we head back into the classroom, understanding the developmental stages of play is crucial for supporting our young autistic students. In this episode, we explore the concept of "exploratory play"—a stage where children might dump toys, throw objects, or mouth everything. Instead of seeing these actions as a lack of play skills, we'll discover how they are part of a natural developmental process. Join me as I discuss how "put in" and "take out" activities can guide children in this exploratory stage toward more functional play. Let's get started! Topics Discussed: Exploratory play Put in activities Take out activities Suggestions for types of activities to use Next steps to expand   Links Mentioned In This Episode About Visual Supports:  Take Out The Toys Booklet Put In & Take Out Toys List On Amazon Themed Play Visual Supports Podcast Episode About Exploratory Play Blog Post About Exploratory Play The Hanen Centre   Other Links You May Be Interested In: Autism Little Learners on Instagram Autism Little Learners on Facebook You can also join my free Visual Supports Facebook Group to “hang out” with like-minded educators and parents who want to take action and implement visuals at home or school. Be sure to subscribe to The Autism Little Learners Podcast so you don't miss future episodes.  Plus, leave a rating & review on iTunes….this will help other educators and parents find this podcast!  CLICK HERE to leave a review on iTunes, then scroll down to “ratings and reviews” and click “write a review”.  THANK YOU!

In this episode, your hosts Judy Jablon and Nichole Parks are joined by mother, wife, and LFC's Former Chief of Staff, Gretchen Henderson, for a conversation about what it can look and feel like to have and cultivate exploratory learning experiences, and how this helps to create thriving communities for children.Show notes: LFC's book 11 Simple Rules to Create Thriving Communities for Children is available for purchase here.A quote to take away: Gretchen shared, “When I think about exploratory, I think about curiosity. The big phrase for me is, 'what if?' I think about experiments - creativity, hands-on, trial and error - and especially, I think, with a little bit of risk taking."Thanks for listening!

In this episode of the Experts in Sport podcast, host Stuart McErlain-Naylor is joined by guest Judd Kalkhoven, from Western Sydney University, to discuss common misconceptions within the scope of sports injury research.Timestamps:0.00-4.50 - Intro4.51-13.34 - Research and inspiration - causal models13.35-22.53 - Implications for research findings22.54-26.14 - Exploratory research to show statistical relationships26.15-28.18 - Transitioning research from the lab to the field28.19-30.11 - Do intended applications influence lab work?30.12-33.55 - Including practitioners in research33.56-45.44 - Need for research prior to practical application 45.45-54.10 - Prediction vs. causation54.11-56.44 - Outro and further work

Tommy & Josh are the co-owners of Watch Hill Proper located in Louisville, Kentucky. Watch Hill Proper is the largest American Whiskey bar in the world. The point of the American Whiskey Show is to have fun with whiskey and to share a little knowledge about it in the process. Grab a pour and join us on our journey. Episode 23: Featuring Doc Swinson's Exploratory Cask "El Cuerpo" www.watchhillproper.com

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Dr. Domenica Lorusso to discuss the survival analysis of the PAOLA1 trial. Dr. Domenica Lorusso, MD, PhD, directs the Gynaecological Oncology Unit at Humanitas Hospital, Milan, and holds a Full Professorship in Obstetrics and Gynaecology at Humanitas University, Rozzano, Milan. She has led/participated in approximately 250 phase I-IV clinical trials. Currently overseeing more than 60 studies as Principal Investigator, Dr. Lorusso also chairs the Clinical Trials Committee of the MITO Group. She serves on the Board of Directors of the GCIG and is an active member of ENGOT, where she chairs the Gynecological Cancer Academy. Additionally, she sits on the Board of Directors of the ESGO. With around 300 international oncology publications and contributions to national and international treatment guidelines, her primary objectives are to ensure optimal patient care, foster clinical research, and advance international collaborations and education in the field.   Highlights: Bevacizumab plus olaparib has reported to increase PFS and OS in advanced stage III-IV, newly diagnosed, high grade serous and endometrioid HRD positive ovarian cancer in the maintenance setting  Exploratory analysis suggest that the advantage is particularly high in low risk patients (stage III withour residual tumor at primary surgery) where  a 5-year OS more  than 90% has been reported suggesting some of these patients may be cured In the HRp population the combination of olaparib-bevacizumab did non increase PFS and OS in comparison to bevacizumab alone The toxicity profile of the combination is in line with what expected with the single drugs

In this podcast, JPEN Editor-in-Chief Dr. Kenneth Christopher interviews Kym Wittholz, a clinical lead critical care dietitian and PhD candidate whose specific interest is in critical care nutrition at The Royal Melbourne Hospital in Melbourne, Australia, and the first author of the research article “Plasma beta-hydroxy-beta-methylbutyrate availability after enteral administration during critical illness after trauma: An Exploratory study”. Business Corporate by Alex Menco | alexmenco.net Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US May 2024

Listen in as LeiLani discusses with guest Ki Karou of MIND Education what it means to use game-based learning, visual learning, in helping learners build mental schema and problem-solve.  This is a complex topic that Karou is an expert in, being the Lead Mathematician and Product Director at MIND Education.  Karou's application of game theory and rich background in cognitive sciences makes for an excellent conversation on what edtech is doing today to drive true personalization with exploratory learning. 

In this short episode of the JAG podcast, Editor-in-Chief Debra Dobbs meets with author Eilon Caspi to discuss the findings of his recent paper on the fear of nursing home residents of reprisal from facility staff when voicing care concerns and making mistreatment complaints.

Steff Yotka is the Head of Content at SSENSE. Fresh off of a return flight from Michèle Lamy's 80th birthday rave at a discreet Venetian airport hanger, she joins the crew to discuss the merits of caviar and egg sandwiches as drunk food, non-algo bait editorial, storytelling around product, if you don't like Lana Del Ray please leave, whether or not “menswear is in crisis,” and more. Hosted on Acast. See acast.com/privacy for more information.

“The quality is connected to the risk, and the risk is connected to the testing. If we don't keep an eye on quality, our testing and development will drift, because we are no longer building the thing that people care about anymore." Mark Winteringham is a quality engineer and the author of “Testing Web APIs”. In this episode, discover how holistic, risk-based testing strategies can transform your software quality. Mark explains how to prioritize our testing by understanding what users truly value and translating that into different risk-based testing strategies, such as testing API design, exploratory testing, automated testing, and acceptance test-driven design (ATDD). Mark also reveals the testing Venn diagram as our testing strategic roadmap. Finally, get a glimpse of Mark's upcoming book “AI-Assisted Testing” and learn how AI will evolve the roles of testers and developers.   Listen out for: Career Journey - [00:01:24] Writing “Testing Web APIs” - [00:05:17] Holistic Testing Strategy - [00:07:48] Start With Understanding the Problem - [00:11:02] Testing Venn Diagram Model - [00:14:11] Risk-Based Testing - [00:18:22] Defining Quality & Quality Attributes - [00:22:29] Testing API Design - [00:26:41] Exploratory Testing - [00:32:08] Automated Testing - [00:36:18] Acceptance Test-Driven Design (ATDD) - [00:41:54] “AI-Assisted Testing” Book - [00:45:51] Evolution of Developer and Tester Roles - [00:48:46] 3 Tech Lead Wisdom - [00:53:51] _____ Mark Winteringham's BioMark Winteringham is a quality engineer, course director, and author of “AI Assisted Testing” and “Testing Web APIs”, with over 10 years of experience providing testing expertise on award-winning projects across a wide range of technology sectors. He is an advocate for modern risk-based testing practices, holistic based Automation strategies, Behaviour Driven Development and Exploratory testing techniques. Follow Mark: LinkedIn – linkedin.com/in/markwinteringham/ Twitter / X – @2bittester Website – mwtestconsultancy.co.uk _____ Our Sponsors Manning Publications is a premier publisher of technical books on computer and software development topics for both experienced developers and new learners alike. Manning prides itself on being independently owned and operated, and for paving the way for innovative initiatives, such as early access book content and protection-free PDF formats that are now industry standard.Get a 45% discount for Tech Lead Journal listeners by using the code techlead45 for all products in all formats. Like this episode? Show notes & transcript: techleadjournal.dev/episodes/172. Follow @techleadjournal on LinkedIn, Twitter, and Instagram. Buy me a coffee or become a patron.

The Party defends Fait and his thesis. Mori goes see themselves, Todd gets horny, Fait breaks, Eldrin becomes what he fears most, Fait breaks some barriers, and Baba is out of his locale.Support the Party and get some loot in return: https://www.patreon.com/gmdlcastJoin our Discord: https://discord.gg/RsMGSP2DhCWatch our stream: https://www.twitch.tv/gmdlcast Spread the word: https://gmdlcast.com/listenFind us: https://bsky.app/profile/gmdlcast.bsky.socialhttps://www.threads.net/@gmdlcast

Seth and Sean react to Adam Schefter reporting that Russell Wilson had an "exploratory" meeting with the Giants, and dive into the worst Quarterback trades of all time.

Rounding Up Season 2 | Episode 13 – Rough Draft Math Guest: Dr. Amanda Jansen Mike Wallus: What would happen if teachers consistently invited students to think of their ideas in math class as a rough draft? What impact might this have on students' participation, their learning experience, and their math identity? Those are the questions we'll explore today with Dr. Mandy Jansen, the author of “Rough Draft Math,” on this episode of Rounding Up.  Mike: Well, welcome to the podcast, Mandy. We are excited to be talking with you.  Mandy Jansen: Thanks, Mike. I'm happy to be here.  Mike: So, I'd like to start by asking you where the ideas involved in “Rough Draft Math” originated. What drove you and your collaborators to explore these ideas in the first place?  Mandy: So, I work in the state of Delaware. And there's an organization called the Delaware Math Coalition, and I was working in a teacher study group where we were all puzzling together—secondary math teachers—thinking about how we could create more productive classroom discussions. And so, by productive, one of the ways we thought about that was creating classrooms where students felt safe to take intellectual risks, to share their thinking when they weren't sure, just to elicit more student participation in the discussions. One way we went about that was, we were reading chapters from a book called “Exploring Talk in School” that was dedicated to the work of Doug Barnes. And one of the ideas in that book was, we could think about fostering classroom talk in a way that was more exploratory. Exploratory talk, where you learn through interaction. Students often experience classroom discussions as an opportunity to perform. "I want to show you what I know.” And that can kind of feel more like a final draft. And the teachers thought, “Well, we want students to share their thinking in ways that they're more open to continue to grow their thinking.” So, in contrast to final draft talk, maybe we want to call this rough draft talk because the idea of exploratory talk felt like, maybe kind of vague, maybe hard for students to understand. And so, the term “rough draft talk” emerged from the teachers trying to think of a way to frame this for students.  Mike: You're making me think about the different ways that people perceive a rough draft. So, for example, I can imagine that someone might think about a rough draft as something that needs to be corrected. But based on what you just said, I don't think that's how you and your collaborators thought about it, nor do I think that probably is the way that you framed it for kids. So how did you invite kids to think about a rough draft as you were introducing this idea?  Mandy: Yeah, so we thought that the term “rough draft” would be useful for students if they have ever thought about rough drafts in maybe language arts. And so, we thought, “Oh, let's introduce this to kids by asking, ‘Well, what do you know about rough drafts already? Let's think about what a rough draft is.'” And then we could ask them, “Why do you think this might be useful for math?” So, students will brainstorm, “Oh yeah, rough draft, that's like my first version” or “That's something I get the chance to correct and fix.” But also, sometimes kids would say, “Oh, rough drafts … like the bad version. It's the one that needs to be fixed.” And we wanted students to think about rough drafts more like, just your initial thinking, your first ideas; thinking that we think of as in progress that can be adjusted and improved. And we want to share that idea with students because sometimes people have the perception that math is, like, you're either right or you're wrong, as opposed to something that there's gradients of different levels of understanding associated with mathematical thinking. And we want math to be more than correct answers, but about what makes sense to you and why this makes sense. So, we wanted to shift that thinking from rough drafts being the bad version that you have to fix to be more like it's OK just to share your in-progress ideas, your initial thinking. And then you're going to have a chance to keep improving those ideas.  Mike: I'm really curious, when you shared that with kids, how did they react? Maybe at first, and then over time? Mandy: So, one thing that teachers have shared that's helpful is that during a class discussion where you might put out an idea for students to think about, and it's kind of silent, you get crickets. If teachers would say, “Well, remember it's OK to just share your rough drafts.” It's kind of like letting the pressure out. And they don't feel like, “Oh wait, I can't share unless I totally know I'm correct. Oh, I can just share my rough drafts?” And then the ideas sort of start popping out onto the floor like popcorn, and it really kind of opens up and frees people up. “I can just share whatever's on my mind.” So that's one thing that starts happening right away, and it's kind of magical that you could just say a few words and students would be like, “Oh, right, it's fine. I can just share whatever I'm thinking about.”  Mike: So, when we were preparing for this interview, you said something that has really stuck with me and that I've found myself thinking about ever since. And I'm going to paraphrase a little bit, but I think what you had said at that point in time was that a rough draft is something that you revise. And that leads into a second set of practices that we could take up for the benefit of our students. Can you talk a little bit about the ideas for revising rough drafts in a math classroom?  Mandy: Yes. I think when we think about rough drafts in math, it's important to interact with people thinking by first, assuming those initial ideas are going to have some merit, some strength. There's going to be value in those initial ideas. And then once those ideas are elicited, we have that initial thinking out on the floor. And so, then we want to think about, “How can we not only honor the strengths in those ideas, but we want to keep refining and improving?” So inviting revision or structuring revision opportunities is one way that we then can respond to students' thinking when they share their drafts. So, we want to workshop those drafts. We want to work to revise them. Maybe it's peer-to-peer workshops. Maybe it's whole-class situation where you may get out maybe an anonymous solution. Or a solution that you strategically selected. And then work to workshop that idea first on their strengths, what's making sense, what's working about this draft, and then how can we extend it? How can we correct it, sure. But grow it, improve it. Mandy: And promoting this idea that everyone's thinking can be revised. It's not just about your work needs to be corrected, and your work is fine. But if we're always trying to grow in our mathematical thinking, you could even drop the idea of correct and incorrect. But everyone can keep revising. You can develop a new strategy. You can think about connections between representations or connections between strategies. You can develop a new visual representation to represent what makes sense to you. And so, just really promoting this idea that our thinking can always keep growing. That's sort of how we feel when we teach something, right? Maybe we have a task that we've taught multiple times in a row, and every year that we teach it we may be surprised by a new strategy. We know how to solve the problem—but we don't have to necessarily just think about revising our work but revising our thinking about the ideas underlying that problem. So really promoting that sense of wonder, that sense of curiosity, and this idea that we can keep growing our thinking all the time.  Mike: Yeah, there's a few things that popped out when you were talking that I want to explore just a little bit. I think when we were initially planning this conversation, what intrigued me was the idea that this is a way to help loosen up that fear that kids sometimes feel when it does feel like there's a right or a wrong answer, and this is a performance. And so, I think I was attracted to the idea of a rough draft as a vehicle to build student participation. I wonder if you could talk a little bit about the impact on their mathematical thinking, not only the way that you've seen participation grow, but also the impact on the depth of kids' mathematical thinking as well.  Mandy: Yes, and also I think there's impact on students' identities and sense of self, too. So, if we first start with the mathematical thinking. If we're trying to work on revising—and one of the lenses we bring to revising, some people talk about lenses of revising as accuracy and precision. I think, “Sure.” But I also think about connectedness and building a larger network or web of how ideas relate to one another. So, I think it can change our view of what it means to know and do math, but also extending that thinking over time and seeing relationships. Like relationships between all the different aspects of rational number, right? Fractions, decimals, percents, and how these are all part of one larger set of ideas. So, I think that you can look at revision in a number of different grain sizes.  Mandy: You can revise your thinking about a specific problem. You can revise your thinking about a specific concept. You can revise your thinking across a network of concepts. So, there's lots of different dimensions that you could go down with revising. But then this idea that we can see all these relationships with math … then students start to wonder about what other relationships exist that they hadn't thought of and seen before. And I think it can also change the idea of, “What does it mean to be smart in math?” Because I think math is often treated as this right or wrong idea, and the smart people are the ones that get the right idea correct, quickly. But we could reframe smartness to be somebody who is willing to take risk and put their initial thinking out there. Or someone who's really good at seeing connections between people's thinking. Or someone who persists in continuing to try to revise. And just knowing math and being smart in math is so much more than this speed idea, and it can give lots of different ways to show people's competencies and to honor different strengths that students have.  Mike: Yeah, there are a few words that you said that keep resonating for me. One is this idea of connections. And the other word that I think popped into my head was “insights.” The idea that what's powerful is that these relationships, connections, patterns, that those are things that can be become clearer or that one could build insights around. And then, I'm really interested in this idea of shifting kids' understanding of what mathematics is away from answer-getting and speed into, “Do I really understand this interconnected bundle of relationships about how numbers work or how patterns play out?” It's really interesting to think about all of the ramifications of a process like rough draft work and how that could have an impact on multiple levels.  Mandy: I also think that it changes what the classroom space is in the first place. So, if the classroom space is now always looking for new connections, people are going to be spending more time thinking about, “Well, what do these symbols even mean?” As opposed to pushing the symbols around to get the answer that the book is looking for.  Mike: Amen. Mandy: And I think it's more fun. There are all kinds of possible ways to understand things. And then I also think it can improve the social dimension of the classroom, too. So, if there's lots of possible connections to notice or lots of different ways to relationships, then I can try to learn about someone else's thinking. And then I learn more about them. And they might try to learn about my thinking and learn more about me. And then we feel, like, this greater connection to one another by trying to see the world through their eyes. And so, if the classroom environment is a space where we're trying to constantly see through other people's eyes, but also let them try to see through our eyes, we're this community of people that is just constantly in awe of one another. Like, “Oh, I never thought to see things that way.” And so, people feel more appreciated and valued.  Mike: So, I'm wondering if we could spend a little bit of time trying to bring these ideas to life for folks who are listening. You already started to unpack what it might look like to initially introduce this idea, and you've led me to see the ways that a teacher might introduce or remind kids about the fact that we're thinking about this in terms of a rough draft. But I'm wondering if you can talk a little bit about, how have you seen educators bring these ideas to life? How have you seen them introduce rough draft thinking or sustain rough draft thinking? Are there any examples that you think might highlight some of the practices teachers could take up?  Mandy: Yeah, definitely. So, I think along the lines of, “How do we create that culture where drafting and revising is welcome in addition to asking students about rough drafts and why they might make sense of math?” Another approach that people have found valuable is talking with students about … instead of rules in the classroom, more like their rights. What are your rights as a learner in this space? And drawing from the work of an elementary teacher in Tucson, Arizona, Olga Torres, thinking about students having rights in the classroom, it's a democratic space. You have these rights to be confused, the right to say what makes sense to you, and represent your thinking in ways that make sense to you right now. If you honor these rights and name these rights, it really just changes students' roles in that space. And drafting and revising is just a part of that.  Mandy: So different culture-building experiences. And so, with the rights of a learner brainstorming new rights that students want to have, reflecting on how they saw those rights in action today, and setting goals for yourself about what rights you want to claim in that space. So then, in addition to culture building and sustaining that culture, it has to do—right, like Math Learning Center thinks about this all the time—like, rich tasks that students would work on. Where students have the opportunity to express their reasoning and maybe multiple strategies because that richness gives us so much to think about.  And drafts would a part of that. But also, there's something to revise if you're working on your reasoning or multiple strategies or multiple representations. So, the tasks that you work on make a difference in that space. And then of course, in that space, often we're inviting peer collaboration.  Mandy: So, those are kinds of things that a lot of teachers are trying to do already with productive practices. But I think the piece with rough draft math then, is “How are you going to integrate revising into that space?” So eliciting students' reasoning and strategies—but honoring that as a draft. But then, maybe if you're having a classroom discussion anyway, with the five practices where you're selecting and sequencing student strategies to build up to larger connections, at the end of that conversation, you can add in this moment where, “OK, we've had this discussion. Now write down individually or turn and talk. How did your thinking get revised after this discussion? What's a new idea you didn't have before? Or what is a strategy you want to try to remember?” So, adding in that revision moment after the class discussion you may have already wanted to have, helps students get more out of the discussion, helps them remember and honor how their thinking grew and changed, and giving them that opportunity to reflect on those conversations that maybe you're trying to already have anyway, gives you a little more value added to that discussion.  Mandy: It doesn't take that much time, but making sure you take a moment to journal about it or talk to a peer about it, to kind of integrate that more into your thought process. And we see revising happening with routines that teachers often use, like, math language routines such as stronger and clearer each time where you have the opportunity to share your draft with someone and try to understand their draft, and then make that draft stronger or clearer. Or people have talked about routines, like, there's this one called “My Favorite No,” where you get out of student strategy and talk about what's working and then why maybe a mistake is a productive thing to think about, try to make sense out of. But teachers have changed that to be “My Favorite Rough Draft.” So, then you're workshopping reasoning or a strategy, something like that. And so, I think sometimes teachers are doing things already that are in the spirit of this drafting, revising idea. But having the lens of rough drafts and revising can add a degree of intentionality to what you already value. And then making that explicit to students helps them engage in the process and hopefully get more out of it.  Mike: It strikes me that that piece that you were talking about where you're already likely doing things like sequencing student work to help tell a story, to help expose a connection. The power of that add-on where you ask the question, “How has your thinking shifted? How have you revised your thinking?” And doing the turn and talk or the reflection. It's kind of like a marking event, right? You're marking that one, it's normal, that your ideas are likely going to be refined or revised. And two, it sets a point in time for kids to say, “Oh yes, they have changed.” And you're helping them capture that moment and notice the changes that have already occurred even if they happened in their head.  Mandy: I think it can help you internalize those changes. I think it can also, like you said, kind of normalize and honor the fact that the thinking is continually growing and changing. I think we can also celebrate, “Oh my gosh, I hadn't thought about that before, and I want to kind of celebrate that moment.” And I think in terms of the social dimension of the classroom, you can honor and get excited about, “If I hadn't had the opportunity to hear from my friend in the room, I wouldn't have learned this.” And so, it helps us see how much we need one another, and they need us. We wouldn't understand as much as we're understanding if we weren't all together in this space on this day and this time working on this task. And so, I love experiences that help us both develop our mathematical understandings and also bond us to one another interpersonally.  Mike: So, one of the joys for me of doing this podcast is getting to talk about big ideas that I think can really impact students' learning experiences. One of the limitations is, we usually spend about 20 minutes or so talking about it, and we could talk about this for a long time, Mandy. I'm wondering, if I'm a person who's listening, and I'm really interested in continuing to learn about rough draft math, is there a particular resource or a set of resources that you might recommend for someone who wants to keep learning? Mandy: Thank you for asking. So, like you said, we can think about this for a long time, and I've been thinking about it for seven or eight years already, and I still keep growing in my thinking. I have a book called “Rough Draft Math: Revising to Learn” that came out in March 2020, which is not the best time for a book to come out, but that's when it came out. And it's been really enjoyable to connect with people about the ideas. And what I'm trying to do in that book is show that rough draft math is a set of ideas that people have applied in a lot of different ways. And I think of myself kind of as a curator, curating all the brilliant ideas that teachers have had if they think about rough drafts and revising a math class. And the book collects a set of those ideas together.  Mandy: But a lot of times, I don't know if you're like me, I end up buying a bunch of books and not necessarily reading them all. So, there are shorter pieces. There's an article in Mathematics Teaching in the Middle School that I co-wrote with three of the teachers in the Delaware Teacher Study Group, and that is at the end of the 2016 volume, and it's called “Rough-Draft Talk.” And that's only 1,800 words. That's a short read that you could read with a PLC or with a friend. And there's an even shorter piece in the NCTM Journal, MTLT, in the “Ear to the Ground” section. And I have a professional website that has a collection of free articles because I know those NCTM articles are behind a paywall. And so, I can share that. Maybe there's show notes where we can put a link and there's some pieces there.  Mike: Yes, absolutely. Well, I think that's probably a good place to stop. Thank you again for joining us, Mandy. It really has been a pleasure talking with you.  Mandy: Thank you so much, Mike. Mike: This podcast is brought to you by The Math Learning Center and the Maier Math Foundation, dedicated to inspiring and enabling all individuals to discover and develop their mathematical confidence and ability. © 2024 The Math Learning Center | www.mathlearningcenter.org

Welcome to the Conscious Code Series on the EmbodyME Podcast, where we voyage through the transformative realms of Human Design Gates, Gene Keys, and I Ching Hexagrams. In this episode, your host, Crystal Renae, the Soul Brand Alchemist, guides us through the intricate energies of Gate 63, known as the Gate of Doubt or Exploratory Discernment. Situated in the Head Center, Gate 63 invites us on a journey of questioning, challenging the status quo, and ultimately reaching a deeper understanding of ourselves and the universe. Key Highlights: Understanding Gate 63: Uncover the essence of Gate 63, its position in the head center, and its connection through the Channel of Logic to the Ajna center. Learn how this gate fuels our drive for logical processing and critical evaluation, both externally and internally. The Shadow of Doubt: Explore the shadow aspect of Gate 63, where doubt can lead to self-questioning, suspicion, and mental paralysis, impacting our self-worth and trust in ourselves and others. The Gift of Inquiry: Discover how transforming doubt into inquiry can stimulate curiosity, encourage the pursuit of knowledge, and pave the way for personal growth and enlightenment. The Siddhi of Truth: Ascend to the Siddhi state of Gate 63, where the pursuit of truth reveals profound realizations, enlightenment, and a deep sense of inner peace. Applying Gate 63 in Business: Learn how to harness the energy of Gate 63 to foster truth, authenticity, and deeper inquiry within your brand and business practices. This Episode Offers: Insights into the dual nature of doubt and how to leverage it for personal and professional development. Practical advice for navigating the shadows of Gate 63 and embracing its gifts and Siddhi. Contemplative questions to journal on for those with Gate 63 active in their charts. Tips on transforming doubt into a constructive force for inquiry and growth. Join Us: Ready to dive deeper into your brand's alignment and the transformative power of Human Design? Click ⁠here⁠ to register for the Impact by Design free workshop and join our vibrant community eager to embrace their authentic essence in business and life. About Your Host: Crystal Renae is not just your guide through the world of Human Design and Gene Keys; she is a beacon of knowledge, blending her expertise in branding, marketing, and spiritual coaching to help you infuse your authentic essence into your life and business. Subscribe & Connect: Don't miss an episode of the Conscious Code Series. Subscribe to the EmbodyME Podcast on your favorite platform and connect with Crystal Renae for a journey of discovery, alignment, and transformation. Connect with Crystal Renae: ⁠⁠⁠Instagram⁠⁠⁠ ⁠⁠⁠TikTok⁠⁠⁠ ⁠⁠⁠YouTube⁠⁠⁠ ⁠⁠⁠Facebook⁠⁠⁠ ⁠⁠⁠Website⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/iamconsciouslycrystal/message Support this podcast: https://podcasters.spotify.com/pod/show/iamconsciouslycrystal/support

Train More, Behave More @purepawsitivity 2 Different Walks To Know . Exploratory and Structured! #walks #training #life #health #healthy #healthylife #dogs #cats #pets #eatgood #fun #doglife #catlife

Support the show to get full episodes and join the Discord community. You may know my guest as the co-founder of Neuromatch, the excellent online computational neuroscience academy, or as the creator of the Brian spiking neural network simulator, which is freely available. I know him as a spiking neural network practitioner extraordinaire. Dan Goodman runs the Neural Reckoning Group at Imperial College London, where they use spiking neural networks to figure out how biological and artificial brains reckon, or compute. All of the current AI we use to do all the impressive things we do, essentially all of it, is built on artificial neural networks. Notice the word "neural" there. That word is meant to communicate that these artificial networks do stuff the way our brains do stuff. And indeed, if you take a few steps back, spin around 10 times, take a few shots of whiskey, and squint hard enough, there is a passing resemblance. One thing you'll probably still notice, in your drunken stupor, is that, among the thousand ways ANNs differ from brains, is that they don't use action potentials, or spikes. From the perspective of neuroscience, that can seem mighty curious. Because, for decades now, neuroscience has focused on spikes as the things that make our cognition tick. We count them and compare them in different conditions, and generally put a lot of stock in their usefulness in brains. So what does it mean that modern neural networks disregard spiking altogether? Maybe spiking really isn't important to process and transmit information as well as our brains do. Or maybe spiking is one among many ways for intelligent systems to function well. Dan shares some of what he's learned and how he thinks about spiking and SNNs and a host of other topics. Neural Reckoning Group. Twitter: @neuralreckoning. Related papers Neural heterogeneity promotes robust learning. Dynamics of specialization in neural modules under resource constraints. Multimodal units fuse-then-accumulate evidence across channels. Visualizing a joint future of neuroscience and neuromorphic engineering. 0:00 - Intro 3:47 - Why spiking neural networks, and a mathematical background 13:16 - Efficiency 17:36 - Machine learning for neuroscience 19:38 - Why not jump ship from SNNs? 23:35 - Hard and easy tasks 29:20 - How brains and nets learn 32:50 - Exploratory vs. theory-driven science 37:32 - Static vs. dynamic 39:06 - Heterogeneity 46:01 - Unifying principles vs. a hodgepodge 50:37 - Sparsity 58:05 - Specialization and modularity 1:00:51 - Naturalistic experiments 1:03:41 - Projects for SNN research 1:05:09 - The right level of abstraction 1:07:58 - Obstacles to progress 1:12:30 - Levels of explanation 1:14:51 - What has AI taught neuroscience? 1:22:06 - How has neuroscience helped AI?

Interview with David Kelley, President & CEO of Chakana Copper Corp.Our previous interview: https://www.cruxinvestor.com/posts/chakana-copper-tsxvperu-financing-ready-ready-to-drill-4736Recording date: 22nd January 2024Chakana Copper is focused on demonstrating the sizable copper exploration upside at its Soledad project in Peru through an upcoming 2400 meter drill campaign. Having raised over $3 million from renowned resource investor Rick Rule and Goldfields to fund this work, Chakana aims to prove up what it believes could be a major high-grade copper discovery.Situated in a prolifically mineralized tourmaline breccia pipe-hosting region of Peru, Soledad contains exceptionally high-grade copper at surface in pipes analyzed thus far. One intercept graded an impressive 27% copper and nearly 1 kilogram per tonne silver. Mineralization observed has also been continuous, with a drill hole returning 485 meters at over 1% copper from surface.While precious metals like silver and gold predominate near surface, Chakana President and CEO David Kelley views Soledad as fundamentally a premier copper asset. The primary Solita Norte target exhibits clear discovery potential, with Kelley stating if exploration efforts hit mineralization there, “we're going to hit it out of the park for sure.”The Solita Norte target encompasses a 2.5 square kilometer copper and molybdenum anomaly central to surrounding breccia pipes and resides beside key indicators of a significant copper-bearing intrusive center.Positive characteristics notwithstanding, shares in Chakana Copper trade around all-time lows, presenting a compelling risk/reward opportunity. Chakana provides leveraged exposure ahead of both extensive drilling on its copper assets and expectations for multi-year copper supply shortfalls signaling substantially higher prices by 2025. Exploratory success could rerate Chakana considerably higher.—View Chakana Copper's company profile: https://www.cruxinvestor.com/companies/chakana-copperSign up for Crux Investor: https://cruxinvestor.com

Hey all! Welcome to another episode of Mr. P.'s Tales from the Road! In this edition, responding to a listener who asked: “Mr. P., how DID you get into exploring?” I relate my “origin story” of how I got into this weird, utterly fascinating and unquenchable need to explore and document abandoned and odd locations out in the world. From my roaming in and around my hometown as a kid to some late night college tales, answers and, of course, some history abound, so brew some hot tea, get some hot soup a bubblin' on your stove, listen in and enjoy the show! Have a great weekend and we'll see you in next week's episode! -Mr. P. Also now available on APPLE PODCAST!: https://podcasts.apple.com/us/podcast/mr-p-s-tales-from-the-road/id1717990959 MR. P. INFO: The majority of my work gets published at the Mr. P. Explores Facebook Community:⁠ https://www.facebook.com/MrPExplores/⁠  Stop by for full photo explorations, history and stories told from the road! Mr. P. Explores Instagram (extras that never make the site or videos, and much more!):⁠ https://www.instagram.com/mr.p_explores/⁠@mr.p_explores TWITTER (X?):⁠ https://twitter.com/ExploresMr⁠ @ExploresMr  (come on over and say hello!)  Thanks all, and have a great week! I am also now on VERO, @mrpexplores or directly at:⁠ ⁠⁠https://vero.co/mrpexplores⁠

Fostering early language development in young autistic children goes way beyond teaching words.  I'm excited to share 3 ways to encore language development that actually do not involve saying “say train” or “say cracker”.  Do you want to know what you can do instead?  Listen to today's episode for easy tips that you can implement right away! Topics Discussed: Symbolic sounds and exclamatory words People play Exploratory play Links Mentioned In This Episode: Symbolic sounds resources on TpT Take out the toys booklet People play booklet Exploratory toy Amazon list Exploratory play blog post Podcast episode 16: symbolic sounds Podcast episodes 36-39: play Take out activity IG reel Tot Tube IG reel Other Links You May Be Interested In: Autism Little Learners on Instagram Autism Little Learners on Facebook You can also join my free Visual Supports Facebook Group to “hang out” with like- minded educators and parents who want to take action and implement visuals at home or at school. Be sure to subscribe to The Autism Little Learners Podcast so you don't miss future episodes.  Plus, leave a rating & review on iTunes….this will help other educators and parents find this podcast!  CLICK HERE to leave a review on iTunes, then scroll down to “ratings and reviews” and click “write a review”.  THANK YOU!

In this podcast, I take an in-depth look at our current exploratory design process.

You don't want to miss today's episode about pretend play.  We'll start by summarizing the stages of play that we covered in the last several episodes.  Exploratory play, one-step functional play, and two-step functional play are leading children on the path to pretend play!  Now, let's chat about how we can nurture pretend play with our autistic child or students.  See you inside the show! Topics Discussed: Exploratory play Functional play Pretend play Using visual supports for play Links Mentioned In This Episode About Visual Supports:  Exploratory Toys List On Amazon Functional Play Toys List On Amazon Episodes 10, 11, 36 & 37 Mini-Trampoline Toy Playmobile Playground Toy Fisher Price Playground Set Pretend Play Toys Amazon List Themed Play Visual Supports Put Pretending Into Your Child's Play Booklet The Hanen Centre Other Links You May Be Interested In: Autism Little Learners on Instagram Autism Little Learners on Facebook You can also join my free Visual Supports Facebook Group to “hang out” with like minded educators and parents who want to take action and implement visuals at home or at school. Be sure to subscribe to The Autism Little Learners Podcast so you don't miss future episodes.  Plus, leave a rating & review on iTunes….this will help other educators and parents find this podcast!  CLICK HERE to leave a review on iTunes, then scroll down to “ratings and reviews” and click “write a review”.  THANK YOU!

The journey of play development in autistic children may take a different path than it does for typically children, but it doesn't make it any less meaningful!  With each stage, they delve deeper into their understanding of the world around them. For teachers and parents of young autistic children, the journey can be a tad more complicated, and understanding the stages of play becomes crucial. Two fundamental stages in this journey are 'exploratory play' and 'one-step functional play'. Let's take a closer look at these stages and the transition between them in today's episode! Topics Discussed: Exploratory & one-step functional play Examples of ways to transition from exploratory play to functional play Suggestions for types of activities to use Tips for edcuators and parents Links Mentioned In This Episode About Visual Supports:   Put In & Take Out Toys List On Amazon Tot Tube Functional Play Toys List On Amazon Episode 10 Episode 36 Play Blog Posts Themed Play Visual Supports Take Out The Toys Booklet The Hanen Centre Other Links You May Be Interested In: Autism Little Learners on Instagram Autism Little Learners on Facebook You can also join my free Visual Supports Facebook Group to “hang out” with likeminded educators and parents who want to take action and implement visuals at home or at school. Be sure to subscribe to The Autism Little Learners Podcast so you don't miss future episodes.  Plus, leave a rating & review on iTunes….this will help other educators and parents find this podcast!  CLICK HERE to leave a review on iTunes, then scroll down to “ratings and reviews” and click “write a review”.  THANK YOU!

So often our young autistic students come to us with what we think are “no play skills”.  Does your student or child dump toys, throw toys and objects, or mouth everything?  Well, guess what?  That is a developmental stage of play called “exploratory play”.  If your student or child is in this stage of play, there is plenty we can do to nudge them toward functional play.  In today's episode, I'll be talking about how you can use “put in” and “take out” activities for children in this exploratory stage of play.   Topics Discussed: Exploratory play Put in activities Take out activities Suggestions for types of activities to use Next steps to expand Links Mentioned In This Episode About Visual Supports:  Take Out The Toys Booklet Put In & Take Out Toys List On Amazon Themed Play Visual Supports Podcast Episode About Exploratory Play Blog Post About Exploratory Play The Hanen Centre Other Links You May Be Interested In: Autism Little Learners on Instagram Autism Little Learners on Facebook You can also join my free Visual Supports Facebook Group to “hang out” with likeminded educators and parents who want to take action and implement visuals at home or at school. Be sure to subscribe to The Autism Little Learners Podcast so you don't miss future episodes.  Plus, leave a rating & review on iTunes….this will help other educators and parents find this podcast!  CLICK HERE to leave a review on iTunes, then scroll down to “ratings and reviews” and click “write a review”.  THANK YOU!  

In this course #466, learn the play and language skills a child acquires during Stage 1 Exploratory Play from the Stages of Play for Toddlers and Preschoolers with Language Delays, along with activities, strategies, and recommended toys to facilitate each skill and help train parents and other caregivers. Course appropriate for SLPs and other therapists (OT, PT, and EI Developmental Specialists/Therapists) who work with pediatrics in various settings including state or county-based early intervention providers, outpatient pediatric therapy clinics, infant/toddler and preschool programs, and other childcare settings   Link for $5 CEU credit  https://teachmetotalk.com/ceu_course/asha-ceu-course-466-stage-1-exploratory-play-in-stages-of-play-for-toddlers-and-preschoolers-with-language-delays-2/

Bill Eigel, Missouri Gubernatorial Exploratory Candidate | 8-24-23See omnystudio.com/listener for privacy information.

Presidential candidate Gilroy Monsanto (@necrobranson) consults with trusted advisors Kentucky Red (@cushbomb), Harvey Cleese (@intellegint), and Noel Articuno (@charlesraustin) about his forthcoming campaign. E1 on Patreon: https://www.patreon.com/e1podcast

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: The BEST form of exercise to directly combat the aging process is strength training! (2:13) Fyre Fest's Billy McFarland is out of prison and back at it! (9:00) Alec Baldwin is tone-deaf. (11:46) Selective outrage and Kanye West. (13:15) An example of when you don't think things out. (25:34) Food hacks with Butcher Box. (32:17) The food industry is a brutal business. (33:21) Gas-powered all day! (39:03) NYC employees were reinstated for not getting vaccinated. (40:50) Is Jake Paul the future of boxing? (45:03) Technology is cool. (46:52) PRx's new feature and Mind Pump's ideal gym. (49:47) The potential anti-cancer effects of creatine. (54:20) #ListenerLive question #1 - How do you lose fat without losing weight? (57:51) #ListenerLive question #2 - If I keep lifting light instead of lifting to my max every workout, does this help in the long term in preventing those knots I had? (1:13:07) #ListenerLive question #3 - How do you guys recommend incorporating running with your weightlifting programs? (1:25:07) #ListenerLive question #4 - What is the best way to lift weights as a boxer? (1:33:13) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com MIND PUMP LIVE Q&A W/ MAX LUGAVERE Visit Butcher Box for this month's exclusive Mind Pump offer! Visit PRx Performance for an exclusive offer for Mind Pump listeners! November Promotion: MAPS OCR or MAPS Cardio HALF OFF! **Promo code NOVEMBER50 at checkout** Dr. Andy Galpin Post on Strength Training Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Billy McFarland, Fresh Out Of Prison After The Fyre Fest Fiasco, May Be Trying To Launch Another Festival For Some Reason ALEC BALDWIN GETS DRAGGED FOR TONE-DEAF POST ABOUT SHOOTING A WOMAN A YEAR AGO Billionaire No More: Kanye West's Antisemitism Obliterates His Net Worth As Adidas Cuts Ties Mississippi daycare workers fired after screaming at children in Halloween mask LUNA Mexican Kitchen VISCONTI'S RISTORANTE Biden Infrastructure Bill Mandates Vehicle Kill Switches By 2026 Court Orders New York City To Reinstate Unvaccinated Employees Dyson is developing robots that do household chores Exploratory studies of the potential anti-cancer effects of creatine Visit LivON Labs for an exclusive offer for Mind Pump listeners! MAPS Strong MAPS Powerlift Mind Pump #1932: Lifting Heavy Vs. Lifting Light MAPS Symmetry MAPS Prime Webinar Mind Pump #1925: How To Build A Great Physique In 15 Minutes A Day MAPS 15 Minutes   MAPS Fitness Performance   Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Dr. Andy Galpin (@drandygalpin) Instagram Jake Paul (@jakepaul) Instagram