Podcasts about duodenal

VISIT US AT ⁠⁠⁠⁠⁠⁠NCLEXHIGHYIELD.COM⁠⁠⁠⁠⁠⁠ No matter where you are in the world, or what your schedule is like, access the entire course at ⁠⁠⁠⁠⁠⁠⁠⁠www.NCLEXHighYieldCourse.com⁠⁠⁠⁠⁠⁠⁠⁠  The NCLEX High Yield Podcast was featured on ⁠⁠⁠⁠⁠⁠⁠⁠Top 15 NCLEX Podcasts⁠⁠⁠⁠⁠⁠⁠⁠! Make sure you ⁠⁠⁠⁠⁠⁠⁠⁠JOIN OUR NEW VIP FACEBOOK GROUP!⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠https://nclexhighyield.com/blogs/news/nclex-high-yield-quick-links⁠⁠⁠⁠⁠⁠⁠⁠ A topic that confuses many, but listen to how Dr. Zeeshan breaks this bad boy down! Many people get overwhelmed with all the information that's out there, we keep it simple! Join us weekly for FREE Zoom Sessions and be one of the many REPEAT test takers that passed the exam by spending NO MONEY with NCLEX High Yield! NCLEX High Yield is a Prep Course and Tutoring Company started by Dr. Zeeshan in order to help people pass the NCLEX, whether it's the first time , or like the majority of our students, it's NOT their first time. We keep things simple, show you trends and tips that no one has discovered, and help you on all levels of the exam! Follow us on Instagram: ⁠⁠⁠⁠⁠@NCLEXHighYield ⁠⁠⁠⁠⁠or check out our website www.NCLEXHighYield.com Make sure you join us for our FREE Weekly Zoom Sessions! Every Wednesday 3PM PST / 6PM EST. Subscribe to our newsletter at ⁠⁠⁠⁠⁠⁠⁠nclexhighyield.com⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/nclexhighyield/support

In this episode, we review the high-yield topic of Duodenal Atresia⁠⁠ ⁠from the Pediatrics section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

A duodenal ulcer is a sore that develops in the lining of the first part of the small intestine, known as the duodenum. It's often caused by infection with H. pylori bacteria or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Symptoms may include abdominal pain, bloating, nausea, and vomiting. Treatment typically involves antibiotics to eradicate H. pylori, acid-suppressing medications, and lifestyle changes like avoiding irritants such as NSAIDs and alcohol. Untreated ulcers can lead to complications like bleeding or perforation, so prompt medical attention is important.

Can an oral medication replace metabolic surgery? Find out about this and more in today's PV Roundup podcast.

A new research paper was published in Oncotarget's Volume 14 on April 15, 2023, entitled, “Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study.” Duodenal adenocarcinoma (DA) is a rare malignancy without validated tumor markers. In practice, carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) are often used in the management of DA, though their prognostic value is unknown. In this new study, researchers Ellery Altshuler, Raymond Richhart, William King, Mahmoud Aryan, Akash Mathavan, Akshay Mathavan, Keegan Hones, Daniel Leech, Logan Pucci, Joshua Riklan, Pat Haley, Ilyas Sahin, Brian Ramnaraign, Sherise Rogers, Ibrahim Nassour, Steven Hughes, Thomas J. George, and Jesus Fabregas from the University of Florida, University of Florida Health Cancer Center and University of Alabama at Birmingham conducted a single-institution retrospective review including patients diagnosed with biopsy-confirmed adenocarcinoma of the duodenum between 2006 and 2021. “To our knowledge, this is the first study to evaluate the role of tumor markers in patients with DA. In fact, this is the largest single institution study in the US evaluating this disease.” Peri-ampullary tumors were excluded. Levels of CA 19-9 and CEA were collected as continuous variables and were analyzed as binary variables: normal vs. high, using the maximum normal value as a cut-off (normal Ca 19-9

Duodenal switch surgery is a weight-loss procedure that is regarded as the most effective type of bariatric surgery. Dr. Jesse Gutnick joins the Butts and Guts podcast to discuss this operation in detail and shares how it compares to other weight-loss surgeries.

3.21 H. Pylori Microbiology review for the USMLE Step 1 exam Helicobacter Pylori (H. Pylori) is a gram-negative, comma-shaped bacteria that causes chronic gastritis Estimated that 50% of people worldwide are infected with H. Pylori; higher in developing countries, lower in developed countries More common in populations with lower socioeconomic status and in crowded conditions with poor hygiene Spread through oral-oral or fecal-oral routes Colonizes the antrum of the stomach Produces urease that converts urea into carbon dioxide and ammonia, helping it survive in the acidic environment of the stomach Secretes toxins that cause inflammation of the gastric epithelium and lead to gastritis and ulcer formation Most people with H. Pylori never have symptoms, but some may present with dyspepsia, abdominal pain, nausea, vomiting, gastritis, or peptic ulcer disease Duodenal ulcers often associated with H. Pylori or heavy NSAID use Diagnosis can be made through urea breath test, stool antigen test, or endoscopy with gastric biopsy Treated with a triple drug regimen of a proton pump inhibitor, clarithromycin, and amoxicillin or metronidazole (triple therapy) PCAM

Join Drs. Jeremy Levine, Michal Radomski and Lauren Dudas discuss the results of the EAST MCT with PI Rachel Choron.  Hear about management options of duodenal injuries, why they can be so clinically challenging and a bit about spearheading an EAST multicenter trial.  Abstract was presented at the 36th EAST Annual Scientific Assembly.  Look for the publication soon! – “Outcomes Among Trauma Patients with Duodenal Leak Following Primary vs. Complex Repair of Duodenal Injuries: An EAST Multicenter Trial” Supplemental Material: Check out the abstract from the 36th EAST Annual Scientific AssemblyInterested in getting involved in an EAST MCT? - EAST Multicenter Trials - The Eastern Association for the Surgery of Trauma  

This Episode was so fun! PART TWO! We got to talk to JZ @vertical_JZ and Jack @journey2red on instagram who both had VSG surgery on December 7th… while their surgery buddy Steph @bariatricwarrior had her 2nd revision from sleeve to RNY Gastric bypass with appendectomy/ tissue necrosis removal/ adhesion removal/ LT repair/ dilation. YES MEN HAVE WLS TOO! END THE STIGMA! Thank you both for joining us and we will definitely be following along and coming back to talk together as we get further out! We will also be talking with Ashley @ashleykcasaus who had Duodenal switch in a future episode. Next up we will be talking with LC and Reenie again on Post op Plastics as well as our very own Kas who is about to have plastics in January and we are so excited for her. Then soon to follow is Bex and I get to be with both of them post op *fingers crossed* to be a support. I (Steph) have a background in working as a nurse in plastic surgery! So much amazing things to come on @roadtodiscoverypodcast . If you want exclusive first access of episodes, merch goodies, and more sign up to become a patron of patreon , which supports us and gives you perks! Patreon.com/R2DP . We also have merch that not only is cool to wear because its our faces, but it also supports people in the wls community and helps bring awareness and helps end the stigma of wls when you wear it… because people do ask oh hey what is that, which gives an opportunity to start a conversation about WLS and show people that this is an option and its not my 600 lb life. MERCH: https://www.bonfire.com/store/abarijoyfullife/ once again thank you all for your support and love! We love our R2DP family. If you would like to be on a episode please reach out on instagram!

This Episode was so fun! We got to talk to JZ @vertical_jz and Jack @journey2red on instagram who both had VSG surgery on December 7th… while their surgery buddy Steph @bariatricwarrior had her 2nd revision from sleeve to RNY Gastric bypass with appendectomy/ tissue necrosis removal/ adhesion removal/ LT repair/ dilation. YES MEN HAVE WLS TOO! END THE STIGMA! Thank you both for joining us and we will definitely be following along and coming back to talk together as we get further out! We will also be talking with Ashley @ashleykcasaus who had Duodenal switch in a future episode. Next up we will be talking with LC and Reenie again on Post op Plastics as well as our very own Kas @queensparklesleeve who is about to have plastics in January and we are so excited for her. Then soon to follow is Bex and I get to be with both of them post op *fingers crossed* to be a support. I (Steph) have a background in working as a nurse in plastic surgery! So much amazing things to come on @roadtodiscoverypodcast . If you want exclusive first access of episodes, merch goodies, and more sign up to become a patron of patreon , which supports us and gives you perks! Patreon.com/R2DP . We also have merch that not only is cool to wear because its our faces, but it also supports people in the wls community and helps bring awareness and helps end the stigma of wls when you wear it… because people do ask oh hey what is that, which gives an opportunity to start a conversation about WLS and show people that this is an option and its not my 600 lb life. MERCH: https://www.bonfire.com/store/abarijoyfullife/ once again thank you all for your support and love! We love our R2DP family. If you would like to be on a episode please reach out on instagram!

Rylah Joy "rode on the wings of angles and prayer" in the first days of her life to defy all reasonable odds and achieve multiple miracles to survive. And she is not wasting a moment of her time on this earth.  Teamed with her amazing Mumma and fierce advocate Deb, Rylah is shaking up common popular culture assumptions and social stereotypes of Trisomy 21. She is a model, dancer and brand rep loving her life living centre stage. Deb refers to Ryan's Rule during this episode. You can find further information here: https://clinicalexcellence.qld.gov.au/priority-areas/safety-and-quality/ryans-rule  You can find Rylah and her social stories on Insta @Rylah.Joy  You can fine information on Lifeblood's changing requirements for blood donors who have lived in the UK here: https://www.lifeblood.com.au/blood/eligibility/donating-after-travelling/UK You can book an appointment to donate blood by calling 13 14 95 and please consider adding your donation to The Milkshakes for Marleigh Lifeblood Team. 

It's 1AM and the emergency department is calling about *insert terrifying foregut problem you haven't seen since you were an intern here* and you wake up in a cold sweat to realize it was just a dream…this time. Tune in to this clinical challenge episode for some tips and tricks for managing foregut nightmares with Drs. Mike Weykamp, Nicole White, Andrew Wright, and Nick Cetrulo from the University of Washington's Minimally Invasive Surgery team.  Referenced articles and videos:  1.     Rodriguez-Garcia HA, Wright AS, Yates RB. Managing obstructive gastric volvulus: challenges and solutions. Open Access Surgery. 2017 https://www.dovepress.com/getfile.php?fileID=35414 2.     Yates RB. Giant PEH: Management Principles for Unique Clinical Circumstances. 2017 SAGES Annual Meeting. Houston, TX. 2017 https://www.youtube.com/watch?v=vq6cZL2-pho 3.     Millet I, Orliac C, Alili C, Guillon F, Taourel P. Computed tomography findings of acute gastric volvulus. Eur Radiol. 2014.  https://pubmed.ncbi.nlm.nih.gov/25278244/ 4.     Mazaheri P, Ballard DH, Neal KA, Raptis DA, Shetty AS, Raptis CA, Mellnick VM. CT of Gastric Volvulus: Interobserver Reliability, Radiologists' Accuracy, and Imaging Findings. AJR Am J Roentgenol. 2019.  https://pubmed.ncbi.nlm.nih.gov/30403524/ 5.     Barmparas G, Alhaj Saleh A, Huang R, Eaton BC, Bruns BR, Raines A, Bryant C, Crane CE, Scherer EP, Schroeppel TJ, Moskowitz E, Regner JL, Frazee R, Campion EM, Bartley M, Mortus JR, Ward J, Margulies DR, Dissanaike S. Empiric antifungals do not decrease the risk for organ space infection in patients with perforated peptic ulcer. Trauma Surg Acute Care Open. 2021. https://pubmed.ncbi.nlm.nih.gov/34079912/ 6.     Horn CB, Coleoglou Centeno AA, Rasane RK, Aldana JA, Fiore NB, Zhang Q, Torres M, Mazuski JE, Ilahi ON, Punch LJ, Bochicchio GV. Pre-Operative Anti-Fungal Therapy Does Not Improve Outcomes in Perforated Peptic Ulcers. Surg Infect (Larchmt). 2018. https://pubmed.ncbi.nlm.nih.gov/30036134/ 7.     Wee JO. Gastric Volvulus in Adults. In: UpToDate, Louie BE (Ed), UpToDate, Waltham, MA. (Accessed on May 15, 2022.) https://www.uptodate.com/contents/gastric-volvulus-in-adults Please visit behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  

Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine. The most common symptom of a peptic ulcer is stomach pain.Peptic ulcers include: Gastric ulcers that occur on the inside of the stomach and Duodenal ulcers

Are you looking for a bundle of Coach K's Top MSK Cheatsheets? Look no further: www.nptecheatsheets.com Slate presents with reports of a new onset of right shoulder pain without incident. The patient reports symptoms at night between 12:00am – 3:00am, that is quickly relieved by food. Which of the following conditions is the MOST likely present? A. Gastroesophageal reflux B. Chron's disease C. Duodenal ulcer D. Cholecystitis Did you get this question wrong?! If you were stuck between two answers and selected the wrong one, then you need to visit www.NPTEPASS.com, to learn about the #1 solution to STOP getting stuck. --- Support this podcast: https://anchor.fm/thepthustle/support

Katarzyna Pawlak, UEG Journal's social media editor, talks to Elsa Soons (Radboud University Medical Center, The Netherlands) about her recent paper about the endoscopic management of duodenal adenomatosis in familial adenomatous polyposis patients.

Paediatric

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Jacques Bergman who is Professor of Gastrointestinal Endoscopy at the Amsterdam University Medical Center, Amsterdam on "Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study" published in paper copy in Gut in February 2020. Accessible online here: https://gut.bmj.com/content/69/2/295

On this episode we have our first guest Clarissa Calderon talk to us about her amazing weight loss journey with Duodenal Surgery. This momma of triplets is  inspiring to all and we cannot wait for you to hear her story. We also covered cosmetics surgeries some of us hosts have experienced. Be sure to rate, follow and subscribe. Find us on Instagram @sippinwithus 

Dr. David Feliciano discusses the management of duodenal trauma, explains why drains aren't as necessary as you might think, and reveals his love for The Village People and I'm not kidding even a little bit about that last one.

Dr Christopher Thompson discusses his article, "Duodenal mucosal resurfacing: proof-of-concept, procedural development, and initial implementation in the clinical setting" from the October issue.

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately. The third episode features Dr. Jewel Samadder, gastroenterologist and advanced endoscopist at the Mayo Clinic in Phoenix, Arizona. Dr. Samadder has a specific focus on hereditary cancer conditions, with distinct expertise in familial adenomatous polyposis. In this episode, Dr. Samadder discusses the necessary screening, endoscopic and surgical approaches, and chemoprevention options for duodenal neoplasia in FAP. Note: This episode was recorded on July 16th, 2019 and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Episodes to come in Season 2: - "Desmoids" with Dr. James Church and Dr. Dale Shepard - "Thyroid Lesion Management" with Dr. Jennifer Sipos - "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

Focal duodenal necrosis in table-egg layers can be an easily overlooked cause of drops in egg production and egg-case weight loss.

TRENDING TOPIC NACIONAL SEXTA POSICIÓN Consuelo García del Cid nos presenta su nuevo libro "La niña del rincón". Un relato escalofriante de su experiencia en el internado las monjas Adoratrices en Madrid. La escritora nos cuenta las atrocidades de estos "correccionales" franquistas que tanto mal causaron a las menores de aquella época. Continuamos con GH DÚO cubriendo así la cuota de entretenimiento del programa, y contamos esta vez con la participación e @TransfugaVital. Comentamos la final de GHVIP6 y el arranque del último reality de T5. La última parte del programa va a cargo del maestro Joan, otra aportación desastrosa del DJ y vendedor de banderas españolas y lazos amarillos Joan Capdevila. Terminamos la emisión alcanzando en directo la SEXTA posición en tendencias de twitter España, TT6 ES.

Hear how surveillance of duodenal polyps in polyposis syndromes has changed and what some of the genetic implications for these may be. With author Yann Parc, and editorial contributors Sue Clark and Josh Tierney.

02/27/2017 | MDCT of Duodenal Emergencies

A nurse with stage 4 cancer was given 2 years to live after chemo and radiation. She used cannabis oil and is now cancer free.

Episode 9    Dr. John Weigelt is a Professor of Surgery and Chief of the Division of Trauma and Critical Care at the Medical College of Wisconsin. He is also the coordinating editor for Practical Reviews in General Surgery, and the medical director for SESAP 15 sponsored by the American College of Surgeons.   On the podcast he discusses -How SESAP is made -Anticoagulation and Reversal in the Trauma Patient -Managing duodenal trauma

05/12/2014 | Benign and Malignant Duodenal Masses: importance of CT Protocol Design

Upper gastrointestinal bleeding episodes from variceal structures are severe complications in patients with portal hypertension. Endoscopic sclerotherapy and variceal ligation are the treatment options preferred for upper variceal bleeding owing to extrahepatic portal hypertension due to portal vein thrombosis (PVT). Recurrent duodenal variceal bleeding in non-cirrhotic patients with diffuse porto-splenic vein thrombosis and subsequent portal cavernous transformation represent a clinical challenge if classic shunt surgery is not possible or suitable. In this study, we represent a case of recurrent bleeding of duodenal varices in a non-cirrhotic patient with cavernous transformation of the portal vein that was successfully treated with a collateral caval shunt operation.

Background: To analyze risk factors associated with gastro-duodenal ulcers and erosions in children. Methods: Open, prospective, multicenter, case-control study carried out in 11 European countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. Logistic regression models were performed with adjustment for centers and age groups. Results: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). Independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P < 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). Exposure factors for duodenal ulcers were H. pylori infection (P < 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). No risk factor was identified in 97/202 (48.0%) cases. Conclusions:H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. No risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.

In Episode 41 we were joined by Lisa and Patrina for a fun filled hour of weight loss surgery discussion and issues. On this episode we talk about the following stories form this weeks news... Stories we discussed * What 'Fat Talk' Does For Your Body Image * Poop, Weight Loss Surgery & Toilets * Duodenal switch bested gastric bypass for weight loss

Epithelial surfaces such as the gastrointestinal mucosa depend on expression of antimicrobial peptides like cathelicidin for immune defence against pathogens. The mechanisms behind mucosal cathelicidin regulation are incompletely understood. Cathelicidin expression was analysed in duodenal, antral and corpus/fundic mucosal biopsies from African and German patients. Additionally, cathelicidin expression was correlated with Helicobacter pylori (HP) infection and the inflammatory status of the mucosa. High cathelicidin transcript abundance was detected in duodenal biopsies from African subjects. On the contrary, cathelicidin mRNA expression was either undetectable or very low in tissue specimens from German patients. Also, in the antrum and corpus/fundus regions of the stomach significantly higher cathelicidin transcript levels were measured in Tanzanian compared to German patients. In gastric biopsies from African patients cathelicidin expression was increased in HP positive compared to HP negative subjects. Additionally, the inflammatory status measured by IL-8 expression correlated well with the HP infection status. A higher duodenal and gastric cathelicidin expression in African (compared with European) individuals may be due to upregulation by antigenic stimulation and may confer a higher resistance against enteric infections.

This episode: Diet might be the primary factor affecting gut microflora! Show notes: News item 1/News item 2/Journal paperOther interesting stories:**Studying potential new probiotiocs **Bacteria capable of "smelling" **Improving biofuel production **Studying the microbial role in digestion **New kind of chlorophyll discovered Post questions or comments here or email to bacteriofiles at gmail dot com. Thanks for listening!Subscribe at iTunes, check out the show at Twitter, MicrobeWorld, or SciencePodcasters.orgThis show features music from Mevio's podsafe Music Alley.

In Episode 19 we have a brand new contest for you, "I'll have the support please and hold the flaming," and a great site for you Bandsters.

In Episode 18 we end our highlighting of the different bariatric surgeries by taking a look at the RNY. Then we'll introduce you to great site to help you track your daily food and exercise and finish thins up with a some meatballs!

In Episode 17 we take a look at the the vertical banded gastroplasty, find out if a pouch can talk and take a look at a new bariatric recipe site.

Influence of repetitive duodenal application of activated charcoal on the elimination of the elimination of intravenously applied acetaminophen (N-Acetyl-para-aminophenol) The influence of the repeated administration of activated charcoal on elimination of intravenously injected acetaminophen was investigated in an in-vivo model of anaesthetized rats. 40 rats were randomized and divided into four groups of 10 animals, respectively. Concentration of 14C-marked acetaminophen and its metabolites was measured in plasma, urine and small intestine irrigation samples of all animals. To measure the influence of activated charcoal on elimination of acetaminophen, the small intestine of one half of the animals (n=20) was perfused with activated charcoal dissolved in polyethylene glycol (PEG) (= gastrointestinal dialysis), the small intestine of the other half (n=20) was perfused just with PEG. In order to answer the question whether activated charcoal interrupts enterohepatic circulation, half of the rats treated with activated charcoal and half of the PEG-treated animals (n=10, respectively) were subject to bile duct cannulation; the externalized bile was then quantified for acetaminophen. During a testing period of 3.5 hours, in the ileal effluent of animals with physiological bile flow, we detected ca. 20% of the dose administered originally; in the animals subject to cannulation, we found about 7%. 13% of acetaminophen and metabolites were found in the externalized bile. Activated charcoal did not influence the exsorption of acetaminophen into the small intestine. Terminal half-life in blood ranged from 35-51 minutes, there was no statistically significant difference between the groups (P=0.152). Neither did the Area under curve (AUC) – ranging from 2.6 to 3.3 g/min./l. – show significant variation between groups (P=0.392). Concentration of acetaminophen in liver and kidney samples, which were removed post mortem, was very low, ranging from 0.02 to 0.6% of the dose originally administered. Excretion of acetaminophen into urine varied widely (31-56%), correlating with diuresis. The absence of an effect of activated charcoal on elimination of acetaminophen and metabolites may have been caused by exsorption of insufficient amounts into the intestinal lumen.

Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying.Aims: To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-1 receptor antagonist exendin(9-39)amide (ex(9-39)NH2).Methods: Nine healthy volunteers underwent four experiments each. In two experiments with and without intravenous infusion of ex(9-39)NH2 300 pmol/kg/min, a fasting period was followed by intraduodenal glucose perfusion at 1 and 2.5 kcal/min, with the higher dose stimulating GLP-1 release. Antro-pyloro-duodenal motility was measured by perfusion manometry. To calculate the incretin effect (that is, the proportion of plasma insulin stimulated by intestinal hormones) the glycaemia observed during the luminal glucose experiments was mimicked using intravenous glucose in two further experiments.Results: Ex(9-39)NH2 significantly increased glycaemia during fasting and duodenal glucose. It diminished plasma insulin during duodenal glucose and significantly reduced the incretin effect by approximately 50%. Ex(9-39)NH2 raised plasma glucagon during fasting and abolished the decrease in glucagon at the high duodenal glucose load. Ex(9-39)NH2 markedly stimulated antroduodenal contractility. At low duodenal glucose it reduced the stimulation of tonic and phasic pyloric motility. At the high duodenal glucose load it abolished pyloric stimulation.Conclusions: Endogenous GLP-1 stimulates postprandial insulin release. The pancreatic textgreeka cell is under the tonic inhibitory control of GLP-1 thereby suppressing postprandial glucagon. GLP-1 tonically inhibits antroduodenal motility and mediates the postprandial inhibition of antral and stimulation of pyloric motility. We therefore suggest GLP-1 as a true incretin hormone and enterogastrone in humans.

Das Sevesogift 2,3,7,8-Tetrachlorodibenzo-p-dioxin, TCDD, ist das stärkste bisher vom Menschen in die Umwelt gebrachte Gift. Ein großer Anteil seiner toxischen Wirkungen wird auf das hohe Induktionspotential für fremdstoffmetabolisierende Enzyme zurückgeführt. Ziel dieser Arbeit war die Untersuchung der Auswirkung einer nicht letalen TCDD-Belastung auf den Arzneistoffwechsel im Modellversuch an Ratten. Als Pharmakon wurde das gut untersuchte und seit langer Zeit klinisch genutzte Imipramin gewählt. In allen Versuchen wurden die Ratten 48 Stunden vor Untersuchung des Imipraminstoffwechsels mit einer Einzeldosis von 5 µg TCDD/kg Körpergewicht vorbehandelt. Der Imipraminstoffwechsel wurde entweder in vivo durch Bestimmung der Kinetik von Imipramin und seines primären Hauptmetaboliten Desipramin im Plasma der Ratten ermittelt oder in vitro durch Messung des Umsatzes in den Lebermikrosomen bestimmt. Dabei wurden die Konzentrationen von Imipramin und seinen Metaboliten mit einer etablierten HPLC-Methode gemessen. Die Applikation von TCDD und Imipramin in vivo erfolgte bei den Ratten entweder über einen implantierten Duodenal- bzw. Jejunalkatheter oder durch intragastrale Verabreichung mit einer Schlundsonde. Mehrfache Blutproben von Einzeltieren wurden über einen implantierten Carotiskatheter oder aus dem Retroorbitalsinus gewonnen. Der induzierende Effekt der TCDD-Behandlung wurde in den Rattenlebermikrosomen anhand der Deethylierung von Ethoxyresorufin zu Resorufin überprüft. Der Umsatz dieses Substrates der Cytochrom P450-Isoenzyme 1A1 und 1A2 wurde durch die TCDD-Behandlung dreifach gegenüber den Kontrollen erhöht. Dagegen wurde der Abbau von Imipramin durch TCDD weder in den Mikrosomen in vitro, noch bei den Ratten in vivo stimuliert. Im ersten in vivo Versuch mit intraduodenaler Applikation erhöhte TCDD entgegen der Erwartung die Plasmakonzentrationen von Imipramin und Desipramin im Versuchszeitraum von 5 Stunden hoch signifikant um mehr als das Dreifache gegenüber den Kontrollen. Diese Steigerung der Bioverfügbarkeit konnte in weiteren Versuchen mit langsamerer Anflutung nach intragastraler Applikation von Imipramin nicht und auch nach intraajejunaler Gabe nur teilweise reproduziert werden. Die vorliegenden Versuche erlauben keinen Rückschluß auf den Wirkungsmechanismus des paradoxen TCDD-Effekts bei intraduodenaler Imipraminverabreichung. Angesichts der im Vergleich zum Tierversuch wesentlich geringeren TCDD-Belastung ist beim Menschen mit einem solchen Effekt auf den Arzneistoffwechsel jedoch nicht zu rechnen.

Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin. This study should show, whether vasoactive intestinal polypeptide (VIP), a partial agonist of secretin, may also be involved in the mediation of the hydrokinetic effect. Furthermore, plasma concentrations of somatostatin-like immunoreactivity (SLI) were measured in order to check whether this counterregulating hormone is also released by bile and TDC. Twenty investigations were carried out on 10 fasting healthy volunteers provided with a double-lumen Dreiling tube. Bile and TDC were intraduodenally applied in doses of 2-6 g and 200-600 mg, respectively, at 65-min intervals. Plasma samples were withdrawn at defined intervals for radioimmunological determination of VIP and SLI. Duodenal juice was collected in 10-min fractions and analyzed for volume, pH, bicarbonate, lipase, trypsin, and amylase. I.d. application of bile or TDC dose dependently stimulated hydrokinetic and ecbolic pancreatic secretion. Bile exerted a slightly stronger effect than TDC. Pancreatic response was simultaneously accompanied by a significant increase of plasma VIP and SLI concentrations. The effect of bile on integrated plasma VIP and SLI concentrations seems to be dose dependent; the effect of TDC on integrated SLI, too. For the increase of integrated plasma VIP concentrations after TDC no dose-response relation could be established. We conclude that VIP may be a further mediator of bile-induced volume and bicarbonate secretion. The release of plasma SLI indicates that inhibitory mechanisms concomitantly are triggered by i.d. bile and TDC, as already shown during digestion for the intestinal phase of pancreatic secretion.

Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary phosphatidylcholines reduces supersaturation with cholesterol and prevents precipitation of cholesterol crystals in bile of gallstone patients. Seven patients with radiolucent gallstones in functioning gallbladders were studied before (control) and after 5 wk of dietary supplementation with marine fish oil (11.3 gm/day = 3.75 gm n-3 polyunsaturated fatty acids/day). Duodenal bile was collected for analysis during intravenous infusion of cholecystokinin. Gallbladder emptying in response to cholecystokinin was comparable before and during intake of n-3 polyunsaturated fatty acids. Intake of n-3 polyunsaturated fatty acids increased (p < 0.001) the fractions of eicosapentaenoic and docosahexaenoic acids and decreased the fractions of linoleic (p < 0.001) and arachidonic acids (p < 0.02) in biliary phospholipids. Concomitantly, the molar ratio of cholesterol to phospholipids decreased (-19%; p < 0.05). As a consequence, the cholesterol saturation index was reduced by -25% (p = 0.01), from 1.60 ± 0.44 to 1.24 ± 0.38. However, in vitro nucleation time of duodenal bile was not prolonged. The decrease in cholesterol saturation was not sufficient to prevent nucleation of cholesterol crystals in bile of gallstone patients. In conclusion, our data suggest that cholesterol saturation can be influenced by the fatty acid composition of the phosphatidylcholines secreted in bile.