Podcasts about endogenous

Simon & Schuster provided me with an advanced copy of the superb book After the Spike: Population, Progress, and the Case for People, scheduled for release on July 8, 2025. The University of Texas authors, Dean Spears and Michael Geruso, have written a mind-blowing book! It's my second favorite book of 2025! My favorite 2025 book is They're Not Gaslighting You. Video https://www.youtube.com/watch?v=x-JfpjJRkok Podcast   The Population Whimper When I was born, Paul R. Ehrlich's book, The Population Bomb, was a mega-bestseller. Although I never read the book, my generation believed the book's message that humanity is dangerously overpopulated. The book gave me one major reason not to have children. The book made intuitive sense, built on Thomas Malthus's observations, that if our population continues to expand, we will eventually hit a brick wall. However, Ehrlich, a Stanford biologist, made these stunningly wrong predictions in The Population Bomb: Mass Starvation in the 1970s and 1980s: The book opened with the statement, "The battle to feed all of humanity is over. In the 1970s, hundreds of millions of people will starve to death in spite of any crash programs embarked upon now."    England's Demise by 2000: He suggested that England would not exist by the year 2000 due to environmental collapse related to overpopulation.   Devastation of Fish Populations by 1990: He predicted that all significant animal life in the sea would be extinct by 1990, and large areas of coastline would need to be evacuated due to the stench of dead fish.   India's Famine: He predicted catastrophic food shortages in India in the 1990s that did not materialize.   United States Food Rationing by 1984: He envisioned the U.S. rationing food by 1984. Instead of all this doom and gloom, here's what happened: we went from 3.5 billion (when Ehrich wrote his doomsday book) to 8 billion people today, most of whom are fat. Today, our biggest problem isn't famine but obesity. Dean Spears and Michael Geruso's new book should have been called The Population Whimper because it says the opposite of what The Population Bomb said. Forget a catastrophic demographic explosion. We're going to suffer a catastrophic demographic implosion. The graph on the cover of After the Spike sums up the problem: during a 200-year time period, the human population will have spiked to 10 billion and then experienced an equally dramatic fall. Three criticisms of After the Spike For a book packed with counterintuitive arguments, it's remarkable that I can only spot three flaws. Admittedly, these are minor critiques, as they will disappear if we stabilize below 10 billion. 1. Wildlife lost The authors correctly argue that the environment has been improving even as the human population has been growing rapidly. For example: Air and water are now cleaner than they were 50 years ago, when the population was half its current size. Our per capita CO2 consumption is falling. Clean energy production is at an all-time high. There's one metric that authors overlooked: wildlife. As the human population doubled, we've needed more space for growing food. This has led to a decrease in habitat, which is why biologists refer to the Anthropocene Extinction. While fish farms are efficient, overfishing continues. The Amazon gets denuded to make space for soy and cattle plantations. The loss of African wildlife habitats is acute, as the African population is projected to quadruple in this century. I imagine that the authors of After the Spike would counter: National parks didn't exist 200 years ago. Green revolutions and GMO foods have made the most productive farmers ever. De-extinction may restore extinct species. And they're correct. There are bright spots.  However, as we approach 10 billion, wildlife will continue to suffer and be marginalized. The book should have mentioned that. Dean Spears and Michael Geruso would likely agree that if humans continue to grow nonstop, wildlife will continue to suffer. However, they aren't arguing for nonstop human expansion. They want stabilization. When you combine stabilization with technology (e.g., vertical farming and lab-grown animal products), we would reverse the downward trend in wildlife habitat. 2. Increased energy consumption Dean Spears and Michael Geruso celebrate humanity's progress in energy efficiency and productivity. However, they overlook these facts: 1. The Rebound Effect (Jevons Paradox): As energy efficiency improves, the cost of using energy services effectively decreases. This can lead to: Increased usage of existing services: For example, more efficient air conditioners might lead people to cool their homes to lower temperatures or for longer periods. More fuel-efficient cars might encourage more driving. Adoption of new energy-intensive activities: The increased affordability of energy services can enable entirely new consumption patterns that were previously too expensive to adopt. Think about the proliferation of data centers for AI and digital services, or the growth of electric vehicles. While individual electric vehicles (EVs) are more efficient than gasoline cars, the rapid increase in their adoption contributes to overall electricity demand. 2. Economic Growth and Rising Living Standards: Increased demand for energy services: As economies grow and incomes rise, people generally desire greater comfort, convenience, and a wider range of goods and services. This translates to greater demand for heating and cooling, larger homes, more personal transportation, more manufactured goods, and more leisure activities, all of which require energy. Industrialization and urbanization: Developing economies, in particular, are undergoing rapid industrialization and urbanization. This involves massive construction, increased manufacturing, and the expansion of infrastructure, all of which are highly energy-intensive. Even with efficiency gains, the sheer scale of this growth drives up overall energy consumption. Emerging technologies: The growth of data centers, AI, and other digital technologies is leading to a significant increase in electricity demand. 3. Population Growth: While efficiency might improve per unit of output, the overall global population continues to grow. More people, even if individually more efficient, will inherently consume more energy in total. 4. Shifting Economic Structures: Some economies are shifting from less energy-intensive sectors (like agriculture) to more energy-intensive ones (like manufacturing or specific services). Even within industries, while individual processes might become more efficient, the overall scale of production can increase dramatically. 5. Energy Price and Policy Factors: Low energy prices: If energy remains relatively inexpensive (due to subsidies or abundant supply), the incentive for significant behavioral changes to reduce consumption might be diminished, even with efficient technologies available. Policy limitations: Although many countries have energy efficiency policies, their impact may be offset by other factors that drive demand. Conclusion: While technological advancements and efficiency measures reduce the energy intensity of specific activities, these gains are often outpaced by the aggregate increase in demand for energy services driven by economic growth, rising living standards, population increases, and the adoption of new, energy-intensive technologies and behaviors. The challenge lies in achieving a proper decoupling of economic growth from energy consumption, and ultimately, from carbon emissions. Humanity's per capita energy consumption has been steadily increasing with each passing century, a trend that is unlikely to change soon. Therefore, humans of the 26th century will consume far more energy than those of the 21st century.  The authors of After the Spike would probably argue that in 2525, we'll be using a clean energy source (e.g., nuclear fusion), so it'll be irrelevant that our per capita energy consumption increases ten times.  Again, short term, we're going in the wrong direction. However, in a stabilized world, we won't have a problem. 3. Designer babies The authors of After the Spike never addressed the potential impact that designer babies may have. I coined the term "Homo-enhanced" to address our desire to overcome our biological limitations.  Couples are already using IVF to select the gender and eye color of their babies. Soon, we'll be able to edit and select for more complex traits such as height or even intelligence. It's easy to imagine a world like Gattaca, where parents collaborate with CRISPR-powered gene tools to create custom-made babies. One reason some people don't want to reproduce is that it's a crap shoot. Any parent who has more than one child will tell you that each of their children is quite different from the others. Given that they grow up in the same environment, it suggests that genetics is a decisive factor. Until now, we couldn't mold our children's DNA. Soon, we will.  If we were to remove the lottery aspect of having a child and allow parents to design their children, perhaps there would be a baby boom. Dean Spears and Michael Geruso would probably argue that this is unlikely or centuries away from happening. We'll be descending the steep population slope long before we are homo-enhanced. One trillion humans in this millennium? In the Bulgaria chapter of The Hidden Europe, I observed that Bulgaria is depopulating faster than any other European country. Having peaked at 9 million in the late 1980s, a century later, it will be half that size. Despite that, in that chapter, I predicted that in 500 years, we'll have one trillion humans in the solar system, with at least 100 billion on Earth. This video explains how and why that may happen:  https://www.youtube.com/watch?v=8lJJ_QqIVnc Conclusion In 2075, will After the Spike: Population, Progress, and the Case for People look as stupid as The Population Bomb looks 50 years after publication? Does After the Spike make the same errors as The Population Bomb? Paul Ehrlich's underestimated technology and the continued collapse in fertility rates. As Dean Spears and Michael Geruso point out, fertility rates have been declining since they were first measured. Had Ehrlich extrapolated the trendline, he would have realized that our demographic collapse was imminent, not an explosion. Furthermore, technology solved many of the problems Ehrlich imagined. Is After the Spike making the same error? Fertility rates won't fall forever. They must stop. Otherwise, we'll become extinct. However, will fertility rates soar due to technology or some other reason? What could make our fertility rates return to three or more? Here are a few ideas: We master fusion energy, providing us with ultra-cheap energy and dramatically decreasing the cost of having children. Robots perform most jobs, leaving humans with ample time to raise large families.  As the negative effects of depopulation start rippling across the world, a global cultural panic erupts, prompting people to prioritize reproduction. Homo-enhanced humans, merged with artificial general intelligence, decide to proliferate to dominate the planet. Vertical farms and lab-grown cultured meat improve the environment so dramatically that humans feel less guilty about having three or more children, and generous subsidies offset the costs. Admittedly, these scenarios are unlikely to occur during the next 50 years, so After the Spike won't become the joke that The Population Bomb became in 50 years. Still, I predict that Ehrlich's great-great-granddaughter will write The Population Bomb II: Thomas Malthus Will Be Right Someday. Verdict 10 out of 10 stars! Excerpts The excerpts below are from an advanced copy, which may have undergone edits. Hence, some of these excerpts may have been reworded or deleted in the final print. The reason I am quoting them is that even if the excerpts are removed in the final edition, they illustrate the book's overall message.  It would be easy to think that fewer people would be better—better for the planet, better for the people who remain. This book asks you to think again. Depopulation is not the solution we urgently need for environmental challenges, nor will it raise living standards by dividing what the world can offer across fewer of us. Despite what you may have been told, depopulation is not the solution we urgently need for environmental challenges like climate change. Nor will it raise living standards by dividing what the world can offer across fewer of us. To the contrary, so much of the progress that we now take for granted sprang up in a large and interconnected society. Part I's big claim: No future is more likely than that people worldwide choose to have too few children to replace their own generation. Over the long run, this would cause exponential population decline. Whether depopulation would be good or bad depends on the facts and depends on our values. We ask about those facts and values, building up to an overall assessment: Part II and Part III's big claim: A stabilized world population would be better, overall, than a depopulating future. Part IV's big claim: Nobody yet knows how to stabilize a depopulating world. But humanity has made revolutionary improvements to society before— we can do it again if we choose. We won't ask you to abandon your concerns about climate change; about reproductive freedom and abortion access; or about ensuring safe, healthy, flourishing lives for everyone everywhere. We won't ask you to consider even an inch of backsliding on humanity's progress toward gender equity. We insist throughout that everyone should have the tools to choose to parent or not to parent. This book is not about whether or how you should parent. It's about whether we all should make parenting easier. In 2012, 146 million children were born. That was more than in any year of history to that point. It was also more than in any year since. Millions fewer will be born this year. The year 2012 may well turn out to be the year in which the most humans were ever born— ever as in ever for as long as humanity exists. Within three hundred years, a peak population of 10 billion could fall below 2 billion. The tip of the Spike may be six decades from today. For every 205 babies born, human biology, it turns out, would produce about 100 females. Average fertility in Europe today is about 1.5. That means the next generation will be 25 percent smaller than the last. Birth rates were falling all along. For as long as any reliable records exist, and for at least several hundred years while the Spike was ascending, the average number of births per woman has been falling, generation by generation. In the United States in the early 1800s, married white women (a population for whom some data were recorded) gave birth an average of seven times. If life expectancy doubles to 150 years, or quadruples to 300 years, couldn't that prevent the depopulating edge of the Spike? The surprising answer is no. The story of the Spike would stay the same, even if life expectancy quadrupled to three hundred years. In contrast, if adults' reproductive spans also changed, so people had, say, one or two babies on average over their twenties, thirties, and forties and then another one on average over their fifties, sixties, and seventies, then that would stop depopulation— but it would be because births changed, not because later-adulthood deaths changed. Where exactly should humanity stabilize? Six billion? Eight? Ten? Some other number? This book makes the case to stabilize somewhere. Exactly where will have to be a question for public and scientific debate. So the extra greenhouse gas emissions contributed by the larger population would be small, even under the assumption here that the future is bleak and we go on emitting for another century. The environmental costs of a new child are not zero. Not by a long shot. Not yet. But they are falling. Each new person who joins the ranks of humanity will add less CO2 than, well, you over your lifetime. Humanity could choose a future that's good, free, and fair for women and that also has an average birth rate of two. There is no inescapable dilemma. In that kind of future, people who want to parent would get the support that they need (from nonparents, from taxpayers, from everyone) to choose parenting. The most plausible way humanity might stabilize— and the only way this book endorses— is if societies everywhere work to make parenting better. Globally, we now produce about 50 percent more food per person than in 1961. “endogenous economic growth.” Endogenous means “created from the inside.” Ideas do not come from outside the economy. They come from us. Because scale matters, a depopulating planet will be able to fill fewer niches. A threat with a fixed cost: A threat has arisen that will kill all humans (however many) unless a large cost is paid to escape it (such as by deflecting an asteroid) within a certain time period. Could a kajillion lives ever be the best plan? That question goes beyond the practical question that this book is here to answer. Between our two families, we have had three live births, four miscarriages, and three failed IVF rounds. Parenting will need to become better than it is today. That's what we, your authors, hope and believe. The opportunity cost hypothesis: Spending time on parenting means giving up something. Because the world has improved around us, that “something” is better than it used to be. In no case is there evidence that more support for parents predicts more births. Nobody— no expert, no theory— fully understands why birth rates, everywhere, in different cultures and contexts, are lower than ever before. I hope these excerpts compel you to buy the book. If you're still undecided, consider that the book features numerous graphs and illustrations that will rewire your brain. Buy After the Spike: Population, Progress, and the Case for People. Connect Send me an anonymous voicemail at SpeakPipe.com/FTapon You can post comments, ask questions, and sign up for my newsletter at https://wanderlearn.com. If you like this podcast, subscribe and share!  On social media, my username is always FTapon. Connect with me on: Facebook Twitter YouTube Instagram TikTok LinkedIn Pinterest Tumblr   Sponsors 1. My Patrons sponsored this show! Claim your monthly reward by becoming a patron for as little as $2/month at https://Patreon.com/FTapon 2. For the best travel credit card, get one of the Chase Sapphire cards and get 75-100k bonus miles! 3. Get $5 when you sign up for Roamless, my favorite global eSIM! Use code LR32K 4. Get 25% off when you sign up for Trusted Housesitters, a site that helps you find sitters or homes to sit in. 5. Start your podcast with my company, Podbean, and get one month free! 6. In the United States, I recommend trading cryptocurrency with Kraken.  7. Outside the USA, trade crypto with Binance and get 5% off your trading fees! 8. For backpacking gear, buy from Gossamer Gear.  

Welcome to the podcast with Dr. Brendan McCarthy!   This episode takes you deep into the real-world practice of prescribing testosterone therapy for women. This is not a high-level overview—this is a nuts and bolts breakdown: ✅ Who it's for ✅ How it's dosed ✅ What labs to run ✅ What delivery methods are safest ✅ Why it's often done wrong—and how to get it right   With over 20 years of clinical experience, Dr. McCarthy shares the insights no seminar or textbook can offer, including the emotional and psychological challenges women face when beginning testosterone therapy, and the very real fears around side effects and community stigma.  

Dr Scott joins the party and shares some interesting studies about HGH Blood Sweat & Gear 301 Coaches Skip Hill, Andrew Berry, Scott McNally 0:00 teaser - Subq vs IM GH Study 1:00 Intro and Welcome Dr Scott Stevenson to the show 2:00 GH IM vs SubQ 5:20 What is GH and what does it do? 8:30 GH Isoforms and Why GH may work better for some than others 11:18 Endogenous vs exogenous GH 15:00 IM vs SubQ HGH 24:30 Estrogen and HGH 26:45 GH is prescribed Subq 30:00 IGF release from HGH 35:00 IGF levels and bodybuilding progress 42:00 Locally produced IGF vs circulating blood levels 46:00 local growth from site specific insulin 52:20 GH and Insulin Timing ? 1:00:00 increlex vs IGFLR3 1:03:00 Skip getting trolled 1:10:30 Pros that never used IGF 1:14:30 Bonus topic : Painful fatty deposits ✅ Signed Copy of Be Your Own Bodybuilding Coach (15% goes to ASPCA) https://www.ebay.com/itm/205121965946

Welcome to the podcast with Dr. Brendan McCarthy!   In this episode we dive deep into one of the most misunderstood and debated topics in hormone health: testosterone replacement therapy (TRT) for women. You may have heard horror stories—or glowing reviews. But what's the truth? Dr. McCarthy discusses: - Why testosterone matters for women's health - How it affects brain chemistry, mood, bone density, and even breast tissue - Its role after estrogen-suppressing breast cancer treatments - The difference between safe and unsafe TRT - What your provider should be doing to monitor and manage it effectively   Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he's been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement therapy, Dr McCarthy s the only instructor in the nation who teaches BioHRT on live patients. Physicians travel to Arizona to take his course and integrate it into their own practices. Besides hormone replacement therapy, Dr. McCarthy has spoken nationally and locally before physicians on topics such as weight loss, infertility, nutritional therapy and more.   Citations: Popma, Arne, et al. "Cortisol moderates the relationship between testosterone and aggression in delinquent male adolescents." Biological psychiatry 61.3 (2007): 405-411 Likhtik, E., Stujenske, J. M., Topiwala, M. A., Harris, A. Z. & Gordon, J. A. Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat. Neurosci. 17, 106–113 (2014). Brannon, Skylar M., et al. "Exogenous testosterone increases sensitivity to moral norms in moral dilemma judgements." Nature Human Behaviour 3.8 (2019): 856-866.. * M.H.M. Hutschemaekers, R.A. de Kleine, M.L. Davis, M. Kampman, J.A.J. Smits, K. Roelofs,Endogenous testosterone levels are predictive of symptom reduction with exposure therapy in social anxiety disorder,Psychoneuroendocrinology,Volume 115,2020,104612 Barel, E, Abu‐Shkara, R, Colodner, R, et al. Gonadal hormones modulate the HPA‐axis and the SNS in response to psychosocial stress. J Neuro Res. 2018; 96: 1388– 1397. https://doi.org/10.1002/jnr.24259 * Buades-Rotger, M., Engelke, C., Beyer, F. et al. Endogenous testosterone is associated with lower amygdala reactivity to angry faces and reduced aggressive behavior in healthy young women. Sci Rep 6, 38538 (2016). https://doi.org/10.1038/srep38538 Ando, Sebastiano, et al. "Breast cancer: from estrogen to androgen receptor." Molecular and cellular endocrinology193.1-2 (2002): 121-128. Somboonporn, Woraluk, and Susan R. Davis. "Testosterone effects on the breast: implications for testosterone therapy for women." Endocrine reviews 25.3 (2004): 374-388. Donovitz, Gary, and Mandy Cotten. "Breast cancer incidence reduction in women treated with subcutaneous testosterone: testosterone therapy and breast cancer incidence study." European journal of breast health 17.2 (2021): 150. Glaser, Rebecca L., Anne E. York, and Constantine Dimitrakakis. "Incidence of invasive breast cancer in women treated with testosterone implants: a prospective 10-year cohort study." BMC cancer 19.1 (2019): 1271.   Thank you for tuning in and don't forget to hit that SUBSCRIBE button! Let us know in the COMMENTS if you have any questions or what you may want Dr. McCarthy to talk about next!   Check out Dr. Brendan McCarthy's Book! https://www.amazon.com/Jump-Off-Mood-...   -More Links- Instagram: www.instagram.com/drbrendanmccarthy TikTok: www.tiktok.com/drbrendanmccarthy Clinic Website: www.protealife.com

The boys are back and mourning Jose Alvarado's 80-day suspension. They also talk Mick Abel, Aaron Nola, the Celtics sucking, Pete Rose being reinstated, and listen to your messages and updates on the myriad sports out there.  ALSO: Tom MSFS2024 livestream this SATURDAY 5/24 at 5 PM Eastern on Discord. Find our bonus episodes and Discord at: https://www.patreon.com/tenthousandlosses  Follow us on Bluesky:  Podcast: https://bsky.app/profile/10klosses.bsky.social Liam: https://bsky.app/profile/wtyppod.com  Tom: https://bsky.app/profile/tompain.bsky.social Follow us on Twitter: Podcast: https://twitter.com/tenklossespod Liam: https://twitter.com/notliamanders0n Tom: https://twitter.com/tohickontpain  Shoot a message or leave us a voicemail (leave your name and pronouns): 267-371-7218

Luca Fornaro is a senior researcher at CREI and professor at both UPF and the Barcelona School of Economics. In Luca's first appearance on the show, he discusses his expansive work on, hysteresis, stagnation traps, endogenous growth, aggregate demand policies, the medium run, population growth and much more.  Check out the transcript for this week's episode, now with links. Recorded on April 23th, 2025 Subscribe to David's Substack: Macroeconomic Policy Nexus Follow David Beckworth on X: @DavidBeckworth Follow the show on X: @Macro_Musings Follow Luca on X: @LucaFornaro3 Check out our new AI chatbot: the Macro Musebot! Join the new Macro Musings Discord server! Join the Macro Musings mailing list! Check out our Macro Musings merch! Subscribe to David's new BTS YouTube Channel  Timestamps: (00:00:00) – Intro (00:00:51) – Luca's Background (00:03:19) – Hysteresis (00:7:23) – Why Talk About Hysteresis Now? (00:10:55) – Stagnation Trap (00:16:07) – The Medium Run (00:22:25) – Managing Expectations with Automatic Stabilizers (00:28:48) – What About Population Growth? (00:31:47) – The Empirical Side (00:39:24) – Directing Capital Flows (00:42:30) – The Scars of Supply Shocks (00:48:57) – The Nominal GDP Targeting Solution (00:51:28) – Fiscal Stagnation (00:59:21) – Outro

In this episode of The Fuel Run Recover Podcast, I sit down with fellow Dietitian Kylee VanHorn to dive into the world of ketones. We break down what they are, how they work, and whether they have a place in an athlete's fueling strategy. If you've been curious about ketone supplements, their potential benefits, and how they compare to carbohydrates, this episode is for you!What We Cover:✔ What are ketones?✔ Endogenous ketones vs. dietary– is there a difference?✔ The potential mechanisms behind ketones and their role in physical and cognitive performance✔ How ketones are absorbed in the gut and whether they can be used alongside carbohydrates✔ Possible negative side effects of ketone supplements in training and competition✔ How much energy ketones provide compared to carbohydrates✔ The speed of ketone metabolism – do they work as fast as carbs?✔ Can ketones enhance recovery?✔ Key considerations for athletes curious about ketonesKylee brings a wealth of knowledge to this conversation as the founder of Flynutrition, a sports nutrition business dedicated to helping endurance athletes fuel smarter. She is passionate about separating nutrition facts from fads and providing practical fueling solutions. Kylee is also a newly published author of Practical Fueling for Endurance Athletes, a must-read for any runner, cyclist, triathlete, or skier looking to optimize performance through nutrition.You can order Kylee's book Practical Fueling for Endurance Athletes , and learn more about Kylee and Flynutrition at www.flynutrition.orgLooking for the other resources mentioned in today's episode? Get your free fueling and strength training guide for runners here!

A quick update that early registration is now open for Thom's upcoming annual retreat in Sedona, Arizona, this Memorial Day weekend from May 22nd to 26.This is Thom's first retreat in the United States since the epic Maha Kumbha Mela held earlier this year in Prayagraj, India, so Thom has many fascinating new stories to share. The Sedona Rounding Retreat is also your opportunity to gift yourself profound rest and industrial-strength meditation through the daily rounding program. This is your chance to transcend uncertainty in the ever-changing world and celebrate spring surrounded by nature, supported by community, and immersed in wisdom with Thom.  Early registration discounts expire on March 17th, and you can find out more at thomknoles.com/sedona.Jai Guru Deva.Cannabis is widely used for relaxation and is increasingly prescribed for therapeutic purposes. But what effect does it have on our internal “balance”?In this episode, Thom addresses a listener's question about the relationship between cannabis use and the gunas—the balancing agents of Nature, as described in the Vedic worldview.Thom explains why cannabis has an impact on the body, how it interacts with our natural systems, and why our body's own “endogenous cannabinoids” provide a more sustainable and beneficial effect on our physiology.Episode Highlights[00:45] Q - How does cannabis influence the three gunas?[01:20] A - Gunas - Balance Agents of Nature[04:27] Rajas and Tamas - Change and Inertia[07:52] Go Beyond the Three Gunas[11:32] Too Many Spinning Plates[13:47] Endogenous and Exogenous Cannabinoids[17:06] Endocannabinoids from Vedic Meditation[20:11] Like Riding a Bike[22:23] A Balanced State of ConsciousnessUseful Linksinfo@thomknoles.com https://thomknoles.com/https://www.instagram.com/thethomknoleshttps://www.facebook.com/thethomknoleshttps://www.youtube.com/c/thomknoleshttps://thomknoles.com/ask-thom-anything/

Why are emotions not the same as feelings? They are related but not the same - we can't change the emotions that arise (they're physiological but we can change the feelings associated with they are created in our brains. They are an interpretation of our inner world and show up in terms of symptoms of depression and anxiety. Today, I explain the groundbreaking work of Jaak Panksepp and his definitive understanding of the different networks in your brain that can become unbalanced causing problems in your experience of life. His work on mapping the seven neural networks the subconscious mind forever changed the way we see conditions such as longterm depression as a failure of the CARE network for instance or ADHD as an imbalance in the SEEKING network - this understanding enables you to take charge of your health rather than relying on medications and 'experts'.Find Jaak's original presentation herehttps://www.youtube.com/watch?app=desktop&v=65e2qScV_K8&t=868sFor my plant medicine journey please see herehttps://youtu.be/b14RX-A5vn8Order my new book, Mind Medicine

Timeline: Get 10% off Mitopure, clinically proven to boost mitophagy.  Go to timeline.com/vanessa. Welcome back to The Optimal Protein Podcast! In this episode, I am joined by Dr. Scott Sherr, a leading expert in metabolic health, ketones, and mitochondrial optimization. We dive deep into the science of ketones, the metabolic benefits of a high-protein ketogenic diet, and how to optimize your approach for fat loss, muscle preservation, and longevity. We also discuss biohacking mitochondrial optimization with red light therapy and methylene blue! Dr. Sherr brings a wealth of knowledge on how ketones impact energy production, brain function, and overall metabolic health. We explore the synergy between ketones and a higher-protein intake, debunk common myths about keto, and discuss the latest research on how this approach can enhance fat adaptation, satiety, and performance. In This Episode, We Cover: How ketones influence metabolism, brain function, and energy levels Endogenous (natural) and exogenous ketones Why a high-protein keto diet can optimize body composition and fat loss The role of ketones in muscle preservation and recovery Common keto mistakes and how to avoid them The connection between ketones, mitochondrial health and cellular repair Practical strategies for incorporating high-protein keto into your lifestyle including biohacking mitochondrial optimization with red light therapy and methylene blue! Get 20% odd SITEWIDE at Ketogenicgirl.com with the code VANESSA Join the Community! Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.    

Paul Clayton is joined by fx Medicine by BioCeuticals ambassador Dr Adrian Lopresti, who together deep dive into the role of PEA in all conditions (beyond pain), and where PEA can relieve symptoms and support resolution. Paul is an advocate of lifestyle and nutrition in the prevention and management of disease. As a pharmaconutritionist, Paul understands the vital importance of how nutrition impacts chronic disease, and the role that chronic inflammation plays in driving ageing, as well as the onset and development neuroinflammatory and neurodegenerative disease. Together Adrian and Paul examine the role of PEA in the treatment of inflammatory disease states, dosage and supplementing, and its use in the effective management of both acute and chronic conditions. Covered in this episode (00:57) Welcoming Dr Paul Clayton (01:58) What is a Pharmaconutritionist? (09:12) Drivers of ageing (11:15) Introduction to PEA (13:45) Endogenous production of PEA (14:30) Therapeutic benefits of PEA (18:40) PEA supplementation (21:04) PEA and the brain (21:55) Supplemental dosing (22:42) Bioavailability of PEA (25:15) PEA and neuroinflammatory stress (27:06) Drivers of chronic inflammatory stress (30:37) PEA in the treatment of neurodegenerative diseases (31:34) PEA as an alternative to CBD (33:52) Sources and dosage guidelines (42:29) Thanking Paul and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/pea-perspectives-from-a-pharmaconutritionist-with-dr-adrian-lopresti-dr-paul-clayton Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://bit.ly/signupFX ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

Paul Clayton is joined by fx Medicine by BioCeuticals ambassador Dr Adrian Lopresti, who together deep dive into the role of PEA in all conditions (beyond pain), and where PEA can relieve symptoms and support resolution. Paul is an advocate of lifestyle and nutrition in the prevention and management of disease. As a pharmaconutritionist, Paul understands the vital importance of how nutrition impacts chronic disease, and the role that chronic inflammation plays in driving ageing, as well as the onset and development neuroinflammatory and neurodegenerative disease. Together Adrian and Paul examine the role of PEA in the treatment of inflamatory disease states, dosage and supplementing, and its use in the effective management of both acute and chronic conditions. Covered in this episode (00:57) Welcoming Dr Paul Clayton (01:58) What is a Pharmaconutritionst? (09:12) Drivers of ageing (11:15) Introduction to PEA (13:45) Endogenous production of PEA (14:30) Therapeutic benefits of PEA (18:40) PEA supplementation (21:04) PEA and the brain (21:55) Supplemental dosing (22:42) Bioavailability of PEA (25:15) PEA and neuroinflammatory stress (27:06) Drivers of chronic inflammatory stress (30:37) PEA in the treatment of neurodegenerative diseases (31:34) PEA as an alternative to CBD (33:52) Sources and dosage guidelines (42:29) Thanking Paul and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/pea-perspectives-from-a-pharmaconutritionist-with-dr-adrian-lopresti-dr-paul-clayton Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://pages.blackmores.com.au/FXM-signup.html ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

What are endogenous & exogenous technologies, and how can this framework help us bring our ideas to life? Join Modern Mantra founders Nick and Elijah as they catch up on the concepts that have been circulating for them recently.Elijah starts by sharing his recent explorations with music and plant medicine. Find out how making music has deepened his connection with nature, and expanded his understanding of endogenous tools: our inbuilt technologies, such as the breath and the voice.Turning to the ‘exogenous' - our external, tangible technologies - what happens as we start visualizing the invisible? Nick discusses the tech that could change the landscape for healers, & envisions what becomes possible when our inner dimensions begin to synthesize with the digital scape. Tune in to get inspired by ancient wisdom, fresh ideas and new innovation for accessing your core essence, and unlocking the creative magic to start manifesting your visions into reality.Highlights02:24 Tapping into Icaros, the frequencies of nature11:37 Endogenous and exogenous technologies17:48 The body as an interface: ancient practices for recentering23:15 Music making for intimacy with nature, self and others30:50 Digitally visualising the human energy field42:00 When modern science catches up with ancient wisdomSubscribe to the Podcast: https://www.modernmantra.co/contentConnect with us: Instagram:   / modernmantra.co   LinkedIn:   / modern-mantra  Thanks for listening! Follow us on YouTube, Instagram, TikTok or find us on LinkedIn! Join the ModernMantra.co mailing list here.

Please note the recording was before the new NASEM model was released. However, there is still a lot of good information from Dr. Weiss beyond those recommendations. This Real Science Exchange podcast episode was recorded during a webinar from Balchem's Real Science Lecture Series. You can find it at balchem.com/realscience.Most ration formulation software uses the 2001 NRC mineral equations. The basic concept of the 2001 NRC mineral requirements is to feed enough absorbable minerals to maintain adequate labile body stores and fluid concentrations. Minerals are lost each day via excretion in feces and urine, milk production, and incorporation into tissues or the fetus in the case of growing or pregnant animals. We have decent data to predict mineral concentrations of milk, growth, and the fetus; however, the endogenous loss in feces is much harder to capture. Absorption coefficients (AC) for most minerals are exceedingly difficult to measure. (0:29)The NRC requirements are the means of several experiments. Feeding to the mean results in half the cows being fed adequately or in excess, and half are not fed enough. In human nutrition, recommended daily allowances for vitamins and minerals are calculated as the mean plus two standard deviations, which statistically meets the requirement for 97% of the population. Since the standard deviation of the requirement is hard to acquire, human nutrition uses the same standard deviation for energy metabolism, around 20%. Dr. Weiss feels this is a reasonable safety factor for minerals for animals as well. He recommends feeding about 1.2 times the NRC requirement while keeping an eye on the maximum tolerable limit for the mineral in question. (4:59)How do we measure absorption? We measure the minerals in the diet, we apply AC, and we get grams or milligrams of absorbed minerals available for the animal to use. Dr. Weiss details some of the complex methodology involved in trying to obtain AC. Feces contain not only unabsorbed dietary minerals but also endogenous/metabolic minerals (e.g., intestinal cells, enzymes, etc.) and homeostatic excretion of minerals (e.g., dumping excess minerals). In the 2001 NRC, the endogenous fecal for almost every mineral is a function of body weight, which is incorrect. It should be a function of dry matter intake. (8:40)Endogenous fecal losses can also be measured using stable or radioactive isotopes. This method is extremely expensive and if radioactive isotopes are used, management of radioactive waste becomes an issue. Thus, most of the AC for trace minerals that used these methods are 50-60 years old. (15:33)Dr. Weiss details some of the issues with calcium requirements in the 2001 NRC leading to overestimation of calcium absorption for many calcium sources and overestimation of the maintenance requirement due to endogenous fecal being calculated using body weight. Organic and inorganic phosphorus have different AC, so partitioning between organic and inorganic will give a more accurate estimate of the requirement. (16:33)Potassium has a linear antagonistic effect on magnesium. You can feed more magnesium to overcome this antagonism, but you won't ever eliminate it. If you feed a few percent added fat as long-chain fatty acids, Dr. Weiss recommends feeding 10-20% more magnesium to account for soap formation in the rumen. (19:17)It's much more difficult to measure AC for trace minerals due to multiple antagonists, interactions among different minerals, and regulated absorption. In addition, AC for trace minerals is very low, which means a small change in the AC can have a huge impact on diet formulation. All feeds in the NRC system have the same AC for each trace mineral and we know that's not right.  (25:39)Dr. Weiss gives an overview of different trace mineral antagonisms and interactions and details his approach to formulation if he has absorption data for a particular ingredient. He also gives his estimates of revised AC for several minerals. (28:07)In summary, the factorial NRC approach only fits 50% of the population. Feeding an extra 10-20% above the NRC requirement includes about 97% of the population. We need to continue to account for more sources of variation in AC. Interactions need to be top of mind when considering mineral requirements and diet formulation. (37:39)Dr. Weiss takes a series of questions from the webinar audience. (40:50)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

DON MOXLEY is the Sport Science Director at Stemregen, a leader in stem cell science-backed supplements. Driven by a personal mission to help people make necessary changes to alleviate suffering and enhance the well-being of all, he leverages his experience as an athlete, sports scientist, and educator to advance human performance and longevity. Whether he's sharing insights on a podcast, presenting cutting-edge research on stem cells and performance at a wellness conference, or offering practical advice on living an active and fulfilling life, Don makes the science of stem cells and longevity both accessible and actionable.  A former captain and Big Ten Champion with the Ohio State University wrestling team, he also served as the university's first sport scientist. He helped athletes track their progress in strength, cardiovascular fitness, and resilience training, leading to the team's national title and three Big Ten Championships. Throughout his career, Don has guided athletes to remarkable success, including two Olympic medals, four World Championships, seven National Championships, and 23 All-American honors.   Work With Me: Mineral Balancing HTMA Consultation: https://www.integrativethoughts.com/category/all-products  My Instagram: @integrativematt My Website: Integrativethoughts.com   Advertisements:   Viva Rays: Use Code ITP for a Discount https://vivarays.com/   Zeolite Labs Zeocharge: Use Code ITP for 10% off https://www.zeolitelabs.com/product-page/zeocharge?ref=ITP Magnesium Breakthrough: Use Code integrativethoughts10 for 10% OFF https://bioptimizers.com/shop/products/magnesium-breakthrough Just Thrive: Use Code ITP15 for 15% off https://justthrivehealth.com/discount/ITP15 Therasage: Use Code Coffman10 for 10% off https://www.therasage.com/discount/COFFMAN10?rfsn=6763480.4aed7f&utm_source=refersion&utm_medium=affiliate&utm_campaign=6763480.4aed7f   Chapters: 00:00 Introduction to Don Moxley and StemRgen 05:53 The Role of Stem Cells in Recovery 15:02 The Importance of Staying Active 20:20 The Science Behind Stem Regen 28:37 Exogenous Stem Cells vs. Natural Supplements 35:21 The Power of Hyperbaric Therapy 40:37 The Importance of Longevity and Vitality 49:18 Exploring Stem Cells and Their Applications 56:01 The Importance of Micronutrients 01:01:19 Personalized Health and Optimization   Takeaways: HRV is a crucial indicator of recovery and performance. Stem cells play a vital role in the body's healing process. Aging leads to a decline in stem cell production. Staying active is essential for longevity and health. Stem Regen can enhance the body's natural healing abilities. Exercise stimulates the release of beneficial molecules like BDNF. Natural supplements can be more accessible than exogenous stem cell treatments. Maintaining a healthy lifestyle can improve overall well-being. The body responds better to gradual increases in stem cell circulation. It's important to be cautious with supplements and their certifications. Hyperbaric therapy can provide significant relief from chronic pain. STEM Regen protocol led to a rapid recovery from knee pain. Inflammation is a major barrier to healing and performance. Longevity is about feeling good and being active at any age. Hormone replacement therapy can be a natural part of health optimization. Nutrition quality is often compromised in industrial food production. Personalized health strategies are essential for optimal performance. Micronutrients play a critical role in cellular health and recovery. Understanding your body's needs is key to thriving as you age. Supplementation can help address deficiencies in modern diets.   Summary: In this conversation, Matthew Coffman interviews Don Moxley, an expert in exercise physiology and stem cell research. They discuss the importance of heart rate variability (HRV) as a key performance indicator for health and recovery, the role of stem cells in healing and recovery, and how aging affects stem cell production. Moxley shares insights on the benefits of staying active and the significance of supplements like StemRgen in enhancing recovery and performance. The discussion also touches on the differences between exogenous stem cells and natural supplements, emphasizing the importance of a holistic approach to health and wellness. In this conversation, Don Moxley shares his personal journey of overcoming significant health challenges, including a serious knee injury and subsequent MRSA infection. He discusses the transformative effects of hyperbaric therapy and the STEM Regen protocol, which helped him regain mobility and reduce inflammation. The conversation also delves into the importance of longevity, hormone replacement therapy, and the role of nutrition in optimizing health and performance. Moxley emphasizes the need for personalized health strategies and the significance of micronutrients in achieving overall well-being.  

TIME STAMPS: 00:54 Why SUGAR in ALL FORMS is one of the most ADDICTIVE substances to quit, yet one of the most ESSENTIAL to abstain from if you want to get the most out of your diet. 04:00 How KETONES, whether ENDOGENOUS or EXOGENOUS, impact the brain positively to combat PARKINSONS and other NEURODEGENERATIVE DISEASES caused by various types of sugar. 09:02 Using KETOSIS and BHB exogenos ketone supplementation to be at peak performance for the gym, music, and public speaking! 17:00 How can we utilize workout performance enhancers and supplements but stay within reason as to what a proper human diet looks like? 18:50 ARTIFICIAL SWEETENERS - stevia, monk fruit and better alternatives to chemicals such as SUCRALOSE and ASPARTAME. Among COFFEE, ENERGY DRINKS, and PRE-WORKOUTS, which are the most toxic to the body despite the performance benefits many of us find from these supplements to provide? General wisdom on reading nutrition labels and identifying what to avoid! 22:02 Aches, pains, & NEUROTOXICITY-RELATED issues caused by LONG TERM CAFFEINE CONSUMPTION. 23:45 FAT-MOBILIZATION, APPETITE SUPPRESSION and other BENEFITS from CAFFEINE! 27:01 PRIME ENERGY DRINK - honest review and analysis of ingredients. 33:13 Being JACKED or BRINGING DINNER HOME - if you are really committed to ancestral living, what really impresses your CAVE GIRL / CAVE MAN ? :- ) 38:49 Mark Sherwood, from New Castle, UK - questions around WHEY PROTEIN & CASEIN SUPPLEMENTATION - analysis of and supplementation advice for KETO PRO PROTEIN POWDER. 42:49 Jonah Poole - MARYLAND, (US East Coast) - Senior in HIGH SCHOOL and a COMPETITIVE WRESTLER! questions around RAW MILK and other low glycemic carbohydrates. “Do natural sugars like lactose in milk cause glycation in the same way fruit does?” / General thoughts on IRON OVERLOAD and EPIGENETICS.  50:15 Daiva, from Ireland: OXALATE DUMPING: What does this look like? What are oxalates and how can we avoid high oxalate foods? 57:02 Suggested title for Richard's Keto Pro Podcast? “My Free Gift to the World. Your Welcome. Coach Rich.” Email us if you like this (kidding) but seriously check out his show THE KETO PRO PODCAST if you're not subscribed already! 59:02 UNIVERSITY and SCHOOLING OPTIONS for those seeking to embrace self-educating an ANCESTRAL WAY OF LIVING.  1:00:02 Pricing, details, & overview of Coach Richard & Stephen's ONLINE SCHOOL COMMUNITY! LINK FOR SIGNUPS & INFORMATION: https://www.skool.com/low-carb/about / Keto 1-to-1 Consultation – KETO PRO SHOP (theketopro.com)⁠ 01:05:58 L.I.S.S. - Frank Bohne on Raw Carnivore and LYME DISEASE! Discussion the CARNIVORE DIET and CANCER. Check out our recent interview on THE SUPERSETYOURLIFE.COM PODCAST - E291 - Frank Bohne on Raw Meats, Ancestral Living, and Eating to Live! IG: @ instafrank95 01:11:00 WELL DONE CARNIVORE BIKINI ATHLETE ANGELA - CONGRATULATIONS on becoming a NATURAL PRO last weekend! What should our attitude post show be moving forward? 01:13:43 Garrett Grabowsky, from San Diego CA - “Do you think there is any correlation to glycogen stores and muscular output leading to more stimulation?” 01:17:13 Alessandro Pietro, from Italy - advice on LEAN BULKING on the carnivore diet considering SIBO and ways to stimulate his appetite while sticking to an ancestral way of living. The truth about CARBS and their role in BUILDING MUSCLE. 01:23:07 Robyn Miller, from Kansas - General advice on CINNAMON & other spices; advice for VARIETY and cooking for the family! 01:31:12 Beau, from Houston - AESTHETIC & BODY COMPOSITION RESULTS after his first few weeks & general advice for best TRACKING MEASUREMENTS for those new to the carnivore diet. 01:37:03 Dustin, from PARAGUAY- general thoughts & experiences with those recovering from eating disorders, whether mild or traumatizing, whether male or female. 01:42:02 Summary & overview of Colt's 5 week plan to get PEELED. 01:47:04 What COMPETITIVE BODYBUILDERS should view as ESSENTIAL to track during contest prep!

We've long known that building more homes helps keep prices in check at the regional or metro area level, but what about the house down the street? Evan Mast shares two research studies that shed light on this important and controversial question. Originally aired in 2021. Updated show notes.Show notes:Mast, E. (2023). JUE Insight: The effect of new market-rate housing construction on the low-income housing market. Journal of Urban Economics, 133, 103383.Asquith, B. J., Mast, E., & Reed, D. (2023). Local effects of large new apartment buildings in low-income areas. Review of Economics and Statistics, 105(2), 359-375.Bratu, C., Harjunen, O., & Saarimaa, T. (2023). JUE Insight: City-wide effects of new housing supply: Evidence from moving chains. Journal of Urban Economics, 133, 103528.Li, X. (2022). Do new housing units in your backyard raise your rents? Journal of Economic Geography, 22(6), 1309-1352.Guerrieri, V., Hartley, D., & Hurst, E. (2013). Endogenous gentrification and housing price dynamics. Journal of Public Economics, 100, 45-60.Phillips, S., Manville, M., & Lens, M. (2021). Research Roundup: The Effect of Market-Rate Development on Neighborhood Rents. UCLA Lewis Center for Regional Policy Studies.Diamond, R., McQuade, T., & Qian, F. (2019). The effects of rent control expansion on tenants, landlords, and inequality: Evidence from San Francisco. American Economic Review, 109(9), 3365-94.Liu, L., McManus, D. A., & Yannopoulos, E. (2020). Geographic and Temporal Variation in Housing Filtering Rates. Available at SSRN.“Opportunities and Obstacles for Rental Housing Registries,” Jan. 20 Lewis Center event with Assembly member Buffy Wicks and Catherine Bracy. https://youtu.be/vaDTWHxk-I8 

Crypto markets are moving in sympathy with other asset classes as concerns over a global recession and rising tensions in the Middle East proliferate. While prices have recovered somewhat, the uncertainty lingers. Follow our Head of Research David Duong, Senior CES Trader Georg Toropov, Head of Prime Financing Trading Sarah Williamson and Research Analyst David Han as they discuss what happened in markets, the challenges ahead for the Federal Reserve, the current financing situation and what to expect for the rest of 3Q24. They also look at the plethora of web3 and onchain developments including the latest with Eclipse, Avalanche's partnership with the California DMV, Jupiter's announcement to reduce it's JUP supply and the recent Terra hack.2:30 What's driving the big market moves8:25 Market technicals10:25 Potential Fed response15:23 Endogenous crypto catalysts17:50 Financing update, leverage, and margin calls24:18 Crypto flows27:00 ETFs30:40 Onchain updates36:40 Jupiter cutting token supply37:54 Ethereum Pectra upgradePlease like and subscribe to our podcast and visit our research portal for more content.Host: David Duong, CFA - Head of ResearchPanel:Georg Toropov - Senior CES TraderSarah Williamson - Head of Prime Financing Trading David Han - Research Analyst

Discover Daily by Perplexity explores groundbreaking developments in AI, nuclear physics, Yellowstone's geothermal activity, and cancer research. Mistral AI's new language model, Mistral Large 2, boasts 123 billion parameters and outperforms industry leaders in code generation, mathematics, and multilingual capabilities. This AI breakthrough showcases impressive efficiency across programming languages and complex reasoning tasks. Meanwhile, scientists push boundaries to create element 120, potentially the first on the periodic table's eighth row, with the Super Heavy Element Factory in Russia leading this quest for superheavy elements.A dramatic hydrothermal explosion at Yellowstone's Biscuit Basin on July 23, 2024, sent boiling water, mud, and rock 100 feet into the air, damaging a boardwalk and closing the area. This event highlights Yellowstone's dynamic geological nature and the park's history of such explosions, with evidence of at least 16 occurrences over the past 14,000 years. The incident serves as a reminder of the potential dangers lurking beneath Yellowstone's surface and the importance of ongoing geological research.Groundbreaking cancer research reveals the surprising role of ancient viral DNA in tumor immunity. Endogenous retroviruses, long embedded in human DNA, can be reactivated in cancer cells, triggering immune responses that may aid in tumor recognition and elimination. This discovery opens new avenues for cancer treatment, potentially enhancing immunotherapy effectiveness by harnessing these ancient viral elements. The complex interplay between ERVs and tumor immunity highlights the dual nature of these viral remnants in both promoting and suppressing cancer growth.From Perplexity's Discover feed:https://www.perplexity.ai/page/mistral-unveils-large-2-00GRlebXQQiufg1mtooQxghttps://www.perplexity.ai/page/the-creation-of-element-120-zYvKUS_.Q7KiDDzcLZcZKwhttps://www.perplexity.ai/page/yellowstone-s-hydrothermal-exp-k01z1McdR5WHvq71Ypo6vghttps://www.perplexity.ai/page/ancient-viruses-fight-and-fuel-xsWb1JiXQvSJ8ATIChgU6wPerplexity is the fastest and most powerful way to search the web. Perplexity crawls the web and curates the most relevant and up-to-date sources (from academic papers to Reddit threads) to create the perfect response to any question or topic you're interested in. Take the world's knowledge with you anywhere. Available on iOS and Android Join our growing Discord community for the latest updates and exclusive content. Follow us on: Instagram Threads X (Twitter) YouTube Linkedin

The Lenses of Game Design: Part 11 Welcome back, wanderer. Today, we embark on another insightful journey through game design. Joining us once again is Will Shen, Lead Content Designer at Something Wicked Games and former Design Director at Bethesda Game Studios. Will has contributed to iconic titles such as Starfield, The Elder Scrolls V: Skyrim, Fallout 4, and Fallout: 76. Today, we'll delve into the intricacies of digital game level design and quest design using four more of the lenses from "The Art of Game Design.” This episode in the series will examine the lenses of Endogenous Value, Problem Solving, The Eight Filters, and Functional Space – all of which can be brought to bear on Will's specialty. Grab a seat and join in! Will:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠ -> ⁠⁠⁠Twitter⁠⁠ -> ⁠⁠2024 GDC Talk The Corner of Story and Game: -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discord⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Threads⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bluesky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -> Email: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠gerald@storyandgame.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Please let me know if you have any questions or comments on this or any other episode. Be sure to subscribe to the podcast to hear more conversations with professionals in the video game, tabletop, and fiction industries. #WillShen #GameDesigner #LeadContentDesigner #QuestDesign #LevelDesign #Starfire #Skyrim #Fallout #Bethesda #SomethingWickedGames #TheLensOfEndogenousValue #TheLensOfProblemSolving #TheLensOfTheEightFilters #TheLensOfFunctionalSpaces #TheArtOfGameDesign #TheLensesOfGameDesign #GameDesign #GameMechanics #TabletopRoleplayingGames #VideoGames #TheCornerOfStoryAndGame #PodcastsToListenTo #NarrativeDesign #FindTheFun #TheStoryStack #GameDesignTheory #Narratology #Ludology

The field of psychedelics research has exploded in recent years, as scientists dig deeper into the neuroscience and pharmacology of hallucinogens and how their unique properties can be harnessed to understand and treat depression, anxiety, post-traumatic stress disorder, Alzheimer's disease, dementia, and neurodegenerative diseases. Remarkably, the human body produces its own endogenous psychedelics, the reasons for which have implications for understanding the ordinary and extraordinary states of human consciousness, from creativity and dreaming to near death experiences. In this episode, Iris Kulbatski from The Scientist's Creative Services Team spoke with Steven Barker, a professor emeritus at Louisiana State University to learn more about the human body's ability to produce hallucinogenic compounds and their roles in physiological processes. More on this topic https://www.the-scientist.com/features/natural-high-endogenous-psychedelics-in-the-gut-and-brain-71301 https://www.the-scientist.com/infographics/infographic-what-a-trip-71303 The Scientist Speaks is a podcast produced by The Scientist's Creative Services Team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research.

Dr. Nicolas Glynos received his PhD in Molecular & Integrative Physiology from the University of Michigan, where he studied the psychedelic drug DMT in the mammalian brain. They discuss: the history of DMT research; the use of DMT in ayahuasca; whether DMT is found endogenously in animals; why plants produce DMT; pineal gland, DMT & melatonin; the latest research looking at the presence and effects of DMT in the brain; and more.More M&M content about psychedelics: https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=focused_posts#psychedelics #DMT #science #neuroscience #podcast #serotoninSupport the showFind all podcast & written content at the M&M Substack:[https://mindandmatter.substack.com]Learn how to further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off...

Commentary by Dr. Candice Silversides

In this week's issue A large-scale Medicaid study evaluates rates of post-op endophthalmitis following phaco, combined glaucoma-phaco, and glaucoma procedures alone. Endogenous fungal endophthalmitis treatment algorithms - are we any closer to standardized treatment patterns? Massage for congenital lacrimal duct obstruction - fact or fiction? Educational videos created by doctors AND patients seem to be an effective tool for patient education in pediatric uveitis.

In this episode, my guest is Dr. Sean Mackey, M.D., Ph.D., Chief of the Division of Pain Medicine and Professor of Anesthesiology, Perioperative and Pain Medicine and Neurology at Stanford University School of Medicine. His clinical and research efforts focus on using advanced neurosciences, patient outcomes, biomarkers and informatics to treat pain. We discuss what pain is at the level of the body and mind, pain thresholds, and the various causes of pain. We also discuss effective protocols for controlling and reducing pain, including the use of heat and cold, acupuncture, chiropractic, physical therapy, nutrition, and supplementation. We also discuss how pain is influenced by our emotions, stress and memories, and practical tools to control one's psychological perception of pain. And we discuss pain medications, including the controversial use of opioids and the opioid crisis. This episode will help people understand, manage, and control their pain as well as the pain of others. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman AeroPress: https://aeropress.com/huberman Levels: https://levels.link/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Sean Mackey (00:02:11) Sponsors: AeroPress, Levels & BetterHelp (00:06:13) Pain, Unique Experiences, Chronic Pain (00:13:05) Pain & the Brain (00:16:15) Treating Pain, Medications: NSAIDs & Analgesics (00:22:46) Inflammation, Pain & Recovery; Ibuprofen, Naprosyn & Aspirin (00:28:51) Sponsor: AG1 (00:30:19) Caffeine, NSAIDs, Tylenol (00:32:34) Pain & Touch, Gate Control Theory (00:38:56) Pain Threshold, Gender (00:44:53) Pain in Children, Pain Modulation (Pain Inhibits Pain) (00:53:20) Tool: Heat, Cold & Pain; Changing Pain Threshold (00:59:53) Sponsor: InsideTracker (01:00:54) Tools: Psychology, Mindfulness-Based Stress Reduction, Catastrophizing (01:08:29) Tool: Hurt vs. Harmed?, Chronic Pain (01:12:38) Emotional Pain, Anger, Medication (01:20:43) Tool: Nutrition & Pain; Food Sensitization & Elimination Diets (01:28:45) Visceral Pain; Back, Chest & Abdominal Pain (01:34:02) Referenced Pain, Neuropathic Pain; Stress, Memory & Psychological Pain (01:40:23) Romantic Love & Pain, Addiction (01:48:57) Endogenous & Exogenous Opioids, Morphine (01:53:17) Opioid Crisis, Prescribing Physicians (02:02:21) Opioids & Fentanyl; Morphine, Oxycontin, Methadone (02:07:44) Kratom, Cannabis, CBD & Pain; Drug Schedules (02:18:12) Pain Management Therapies, Acupuncture (02:22:19) Finding Reliable Physicians, Acupuncturist (02:26:36) Chiropractic & Pain Treatment; Chronic Pain & Activity (02:31:35) Physical Therapy & Chronic Pain; Tool: Pacing (02:36:35) Supplements: Acetyl-L-Carnitine, Alpha Lipoic Acid, Vitamin C, Creatine (02:42:25) Pain Management, Cognitive Behavioral Therapy (CBT), Biofeedback (02:48:32) National Pain Strategy, National Pain Care Act (02:54:05) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer

In this episode of the Psychedelic Medicine Podcast, Rick Strassman, MD joins to discuss the topic of endogenous DMT. Dr. Strassman is adjunct associate professor of psychiatry at the University of New Mexico in Albuquerque and author of DMT: The Spirit Molecule and The Psychedelic Handbook. His DMT and psilocybin studies in the early 1990s initiated the renewal of human research with psychedelics in the U.S. In this conversation, Dr. Strassman discusses the finer details of DMT, from endogenous production in humans and animals, to visionary experiences and theological implications. Dr. Strassman also covers the research that's been done regarding endogenous DMT, clarifying what we do and don't know about the role of the pineal gland and how this might relate to what is reported during near-death experiences. He also discusses the personal and relational quality of psychedelic experiences induced by DMT, mentioning that unitive mystical experiences were actually rare in the trials he conducted, with more experiences having a personal quality, drawing upon the life experiences and interests of the participants. In closing, Dr. Strassman shares his thoughts on the origins of the visions that many report during DMT use.    In this episode you'll hear: The overlap between psychedelic experiences and meditation techniques The relationship between fear, self-awareness, and difficult DMT experiences The placebo effect and psychedelic research Dr. Strassman's thoughts on non-hallucinogenic psychedelics DMT as a possible treatment for strokes to prevent damage and speed recovery Effects of microdosing in animals and humans   Quotes: “I think the best term for these compounds is psychedelic, which means mind manifesting or mind disclosing, because only one of our fifty-five or so normal volunteers had what one might call a mystical unitive state. … Everybody basically had an experience that was totally dependent on them. It was not inherent in the drug.” [9:45] “You could still speculate that to the extent that non-drug states resemble those brought on by giving DMT… that DMT plays a role in the production of those states. But the data aren't there yet. That's why we need more people doing this research.” [24:16] “If psychedelics are super placebos and if we have a psychedelic drug in our brain, it's attempting to speculate that normally the placebo effect could be mediated by endogenous DMT.” [27:42] “If you starve neurons of oxygen they start dying, but if you add DMT they survive much longer. So there seems to be some neuroprotective effect of DMT on ischemic damage to neurons, at least in the test tube.” [32:27]   Links: Dr. Strassman's website The Psychedelic Handbook by Dr. Strassman DMT: The Spirit Molecule by Dr. Strassman DMT and the Soul of Prophecy: A New Science of Spiritual Revelation in the Hebrew Bible by Dr. Strassman Dr. Strassman on FacebookPrevious episode: Exploring DMT Entities with Matthew Johnson, PhD Psychedelic Medicine Association Porangui

In this episode Dr Louise is joined by world-renowned neuroscientist Dr Lisa Mosconi, PhD. Dr Lisa is Director of the Alzheimer's Prevention Clinic and Women's Brain Initiative at Weill Cornell Medicine in New York and author of bestsellers The XX Brain and Brain Food. Dr Lisa was studying nuclear medicine and neuroscience when her grandmother and her grandmother's three sisters all developed Alzheimer's. Dr Lisa became interested in the cause of Alzheimer's and why women are more susceptible. Her research has shown that, rather than a disease of old age, it starts in midlife and menopause potentially plays a part. Dr Lisa discusses her most recent paper, which found that women who took hormones in midlife to treat their menopause symptoms were less likely to develop dementia than those who hadn't taken oestrogen. Finally, Dr Lisa shares three things to consider about female hormones: Oestrogen, and oestradiol in particular, is the master regulator of women's brains. It really is like saying that oestrogen is to your brain what fuel is for an engine. It keeps your brain running. Endogenous oestrogen (produced within your body) is different from exogenous oestrogen (synthetic). The bioidentical oestradiol is probably the best one to use because it really maps on the same circuits for your own endogenous oestrogen. I would love for all women to be able to make an informed decision about whether or not hormone therapy is a viable option for them. Many women who are eligible for HRT do not go on HRT out of fear and the fear comes from outdated information, mislabelling on some of the packages. Follow Dr Lisa on Instagram @dr_mosconi Click here to find out more about Newson Health

Mason is joined by Dr Jenny Martin for the second instalment of their conversation exploring the connection between sexuality, altered states of consciousness, and endogenous psychedelics. In today's segment Dr Jenny takes us further into the cervix and its role in female pleasure, highlighting that women, by design, are innately wired to experience mystical states of consciousness through sex. Dr Jenny take us on a wild ride into subtle realms that the body exists in and is a part of, traversing both the science and traditional lore on topics such as quantum and torsion physics, dark matter, piezoelectricity, Kirilian photography, the body's electromagnetic field, HeartMath and more. Exploring how the intelligence behind all of these theories and schools of thought can aid us in understanding our inherent capabilities and how to utilise and potentiate the capacity of our human form, both earthy and otherwise.  Mason shares his knowledge in the area of Taoism, translating many of these concepts through the expression of Five Element Theory and the Taoist organ wheel, marrying the East vs West approach in a relatable and digestible way.  Dr Jenny explains polyvagal theory through the lens of female pleasure, outlining the various elements of perception and stored trauma that can inhibit an individual's ability to experience bodily welfare regardless of the environmental safety that they may physically find themselves in. Furthering our understanding of the mind/body connection and the subtle energetics that are always at play, when engaging in sex, partnered or otherwise. There is just so much terrain covered in this episode, with many threads to explore and tunnels to delve deep into, we are continuously invited to consider what and who we are beyond the confines of the literature we are strategically fed or allowed exposure to, and the societal structures and norms continually imposed on us.  Take a moment, take a breath and let your psyche spiral around the mysteries and magic of your innate metaphysical nature.   Dr Jenny & Mason discuss: - Healing trauma through sexual practice. - Consciousness, physics and the multidimensional nature of the  human body. - HeartMath and reaching altered states through sex. - Polyvagal theory, fear and female pleasure. - Social media and the colloqualisation of trauma. - Relationship as a gateway to spiritual development. - The intersection between sex, pleasure, and reproduction from a biological and spiritual perspective. Guest Links Dr Jenny WebsiteDr Jenny CoursesDr Jenny Substack Mentioned In This Episode Stealing Fire BookDr Daniel KeownA Spark In The Machine BookThe Uncharted Body Book Related Podcasts Sexuality & Endogenous Psychedelics with Dr Jenny Martin Part 1 (EP#205) Connect With Us SuperFeast InstagramSuperFeast FacebookSuperFeast TikTok SuperFeast Online Education   Check Out The Transcript Below: https://www.superfeast.com.au/blogs/articles/sexuality-endogenous-psychedelics-with-dr-jenny-martin-part-2-ep-207  

What is the role of endogenous GLP-1 in the pathophysiology of T2D? Join multidisciplinary experts in T2D: Dr John Anderson, Dr Vivian Fonseca, and Dr Jim Gavin as they discuss the history of GLP-1 discovery and the role of endogenous GLP-1 in the pathophysiology of T2D. John E. Anderson, MD Vivian A. Fonseca, MD, FRCP James R. Gavin III, MD, PhD

Today on the show Mason is joined by Dr Jenny Martin to share a thought-provoking conversation around sexuality, the body's ability to manufacture DMT and other endogenous psychedelics, religion's influence on our relationship to sex, pleasure and wellbeing, and so much more! With a doctorate in psychology and a vast field of knowledge in the areas of female sexuality, consciousness, neuroscience, neuroplasticity, mind-body medicine, and the heart/brain connection, Dr. Jenny knows, from the inside out, just how powerful our body's apparatus can be, especially when we know how to use it! A passionate advocate for feminine pleasure and achieving flow states, joy and total transformation through the art (and science) of sacred sexuality, Dr. Jenny takes us on a journey through history, sharing how prevalent these practices have been for millennia within Christianity and many ancient cultures and schools of thought around the globe. Highlighting that the energetics of the masculine/feminine principle are intrinsic to life and our nature as human beings.  Jenny speaks to the somewhat controversial concept that the original practice of Christianity was explored through the lens of sexuality, allowing us to entertain the notion that perhaps sexiness is next to godliness after all! In all seriousness though, what may be useful to consider in this particular context is the deeper meaning of the colloquial phrase, “cleanliness is next to godliness”  If we delve a little deeper into the meaning of this concept what we're left with is the translation that keeping one's expression of life "clean" or more accurately, ordered, affords us a sense of ease through the application of balanced or measured action. We could also explore what cleanliness or order means in relationship to sexuality and through the lens of the masculine/feminine principle, which is what, at a foundational level, is being spoken of when exploring the potential to use sexual practice as a means to illicit the production of neurotransmitters and endogenous psychedelic substrates such as DMT and oxytocin. Compounds that enable us to cultivate harmony and health within the body and mind.  How do we keep our expression of sexual energy “tidy” not in the inhibited or frigid sense but functionally, applied in the same manner as the master, with reverence and respect for its power and potential capability?  Through the Taoist lens, sexual energy is synonymous with life force energy, so we can confidently hypothesis that the more we can optimise and utilise this currency of energy through application and practice, the more life or aliveness we can experience, hold and entertain.  Dr Jenny and Mason only touched the tip of the iceberg in this explorative chat, join us for part two, coming soon.   Dr Jenny & Mason discuss: - Endogenous psychedelics. - Religion's influence on our relationship to sex, pleasure and well-being.  - Sex as a way of invoking the divine.  - The goddess archetype and the importance of integration when exploring sacred sexuality. - Near-death experiences and endogenous DMT. Female orgasm & the vagus nerve.   Resource Guide Guest Links Dr Jenny WebsiteDr Jenny Substack Mentioned In This Episode Book: The Woman With The Alabaster Jar.The Spirit Molecule Documentary.Literature On Female Orgasm By Barry R Komisaruk.Psychedelic Literature From Michigan University. Related Podcasts Love, Sex, and Psychedelics with Dr. Molly Maloof (EP#137)+   Connect With Us SuperFeast InstagramSuperFeast FacebookSuperFeast TikTok SuperFeast Online Education   Check Out The Transcript Below: https://www.superfeast.com.au/blogs/articles/sexuality-endogenous-psychedelics-with-dr-jenny-martin-ep-205  

Do you sometimes feel down and wish you could boost your mood? You're not alone. Many people are looking for ways to feel better, mentally and physically. That's where "hope molecules" come in. While it's not a term scientists use, it helps us discuss some special brain chemicals. These chemicals, like endorphins and dopamine, have a big say in how you feel each day. What if you could understand these brain chemicals better? What if you knew how to get more of these feel-good molecules naturally? Scientists have been looking into these questions for years.Kringelbach, M. L., & Berridge, K. C. (2017). Pleasure, happiness, and the brain. Oxford Handbook of Philosophy of Emotion, 4, 329-344.,Rothman, R. B., Baumann, M. H., Dersch, C. M., Romero, D. V., Rice, K. C., Carroll, F. I., & Partilla, J. S. (2019). How stimulants affect the brain. Synapse, 39(1), 32-41. In this article, we'll talk about these special chemicals one by one. We'll discuss what Hope Molecules do, why you might not have enough of them, and how you can get more through what you eat, exercise, and supplement your diet. We'll also cover lifestyle factors that influence them the most. All of this is based on real science to help you take steps to feel better. What are "Hope Molecules"? The term "hope molecules" is a memorable way to discuss a group of critical neurotransmitters in our brain. Based on how they work, you'll find that the term "Hope Molecule" is an appropriate term to describe them. These are the biochemical messengers that significantly influence our emotions and overall well-being. When you're feeling good, chances are your levels of these particular molecules are balanced. On the flip side, imbalances can lead to feelings of stress, unhappiness, or even physical discomfort. The key players in this biochemical dance are: Endorphins: Often referred to as natural painkillers, endorphins elevate your mood and can even produce a sense of euphoria. Dopamine: This neurotransmitter acts like a reward system for your brain, providing feelings of pleasure and satisfaction. Oxytocin: Commonly known as the "love hormone," oxytocin strengthens social bonds and enhances feelings of trust and empathy. Serotonin: This molecule contributes to your sense of happiness and well-being, and it also plays a role in regulating your sleep and appetite. Brain-Derived Neurotrophic Factor (BDNF): This unique molecule supports the health of your brain cells and improves cognitive functions like learning and memory. In the following sections, we'll delve into each of these neurotransmitters in detail. We'll explore their roles, why you might be lacking in them, and how to naturally boost their levels through lifestyle choices like diet and exercise. And rest assured, every point is supported by credible scientific research to guide you in making informed decisions.Gold, P. E. (2015). The role of acetylcholine in learning and memory. Neurobiology of Learning and Memory, 104, 3-10.,Southwick, S. M., Bonanno, G. A., Masten, A. S., Panter-Brick, C., & Yehuda, R. (2018). What is resilience? European Journal of Psychotraumatology, 5(1), 25338. Endorphins: The Uplifting Hope Molecule Endorphins are the first of the Hope Molecules we'll look at. They are primarily produced in the pituitary gland and released into the bloodstream during moments of stress and pain. They act on the opiate receptors in your brain, much like morphine or other prescription painkillers, but without the addictive qualities.Akil, H., Watson, S. J., Young, E., Lewis, M. E., Khachaturian, H., & Walker, J. M. (1984). Endogenous opioids: biology and function. Annual Review of Neuroscience, 7(1), 223-255. Their primary role is to inhibit the transmission of pain signals and promote a sense of euphoria. Causes of Endorphin Deficiency Chronic Stress: When stress becomes a long-term companion, your body prioritizes releasing stress hormones like cortisol over mood...

Did Neoplatonism influence Kabbalah? Exploring the reception of Neoplatonism in Early Kabbalah via three themes: Negative Theology, Unio Mystica and Emanationism. 00:00 Three Themes from Neoplatonism to Kabbalah 00:37 Collab shout out 01:01 What is Emanationism & the Theory of the Forms? 05:12 What is Unio Mystica? 05:56 What is Negative Theology? 06:45 Disclaimers: Pitfalls of Comparison 08:09 The Jewish Neoplatonists 12:44 Mystical Union in Early Kabbalah 17:02 Philo tho… 21:19 Negative Theology in Early Kabbalah 28:29 The Tension 33:43 An Esoteric En Sof 36:51 Sefirot & Emanation in Early Kabbalah 45:36 Exogenous vs Endogenous 47:22 A Human Question 52:10 Summary 53:28 Shout out and Thank you Sources and Further Reading • Adam Afterman, “And They Shall Be One Flesh,” On the Language of Mystical Union in Judaism, BRILL (2016), pp. 25-7, 79-101, 130-50 • Daniel Matt, “Ayin: The Concept of Nothingness in Mystical Judaism,” in The Problem of Pure Consciousness: Mysticism and Philosophy by Robert Forman (ed.), New York, 1990, pp. 121-159 • Gershom Scholem, Kabbalah (Jerusalem, 1974), p. 88 • Gershom Scholem, Origins of the Kabbalah, 1950, pp. 265-71, 431-45 • Moshe Idel, “Jewish Kabbalah and Platonism in the Middle Ages and Renaissance” in Lenn Goodman, Neoplatonism and Jewish Thought, State University of New York Press, 1992, pp. 325-27, 338-340 • Moshe Idel, Metamorphoses of a Platonic Theme in Jewish Mysticism, pp. 67-8 • Moshe Idel, Absorbing Perfections: Kabbalah and Interpretation (New Haven: Yale University Press, 2002), pp. 239–49 • Moshe Idel, Kabbalah: New Perspectives, 1988, pp. 31-2 • Sarah Pessin, “Jewish Neoplatonism: Being above Being and Divine Emanation in Solomon Ibn Gabirol and Isaac Israeli” The Cambridge Companion to Medieval Jewish Philosophy, edited by Daniel H. Frank and Oliver Leaman, Cambridge University Press, Cambridge, 2003, pp. 91–110 • Raphael Jospe, "Chapter Three. Jewish Neoplatonism: Isaac Israeli and Solomon ibn Gabirol". Jewish Philosophy in the Middle Ages, Boston, USA: Academic Studies Press, 2009, pp. 79-131 Join us: https://discord.gg/EQtjK2FWsm https://facebook.com/seekersofunity https://instagram.com/seekersofunity https://www.twitter.com/seekersofu https://www.seekersofunity.com Thank you to our beloved Patrons: jXaviErre, Eny, Kim, Michael, Kirk, Ron, Seth, Daniel, Raphael, Daniel, Jason, Sergio, Leila, Wael, jXaviErre, Simona, Francis, Etty, Stephen, Arash, William, Michael, Matija, Timony, Vilijami, Stoney, El techo, Stephen, Ross, Ahmed, Alexander, Diceman, Hannah, Julian, Leo, Sim, Sultan, John, Joshua, Igor, Chezi, Jorge, Andrew, Alexandra, Füsun, Lucas, Andrew, Stian, Ivana, Aédàn, Darjeeling, Astarte, Declan, Gregory, Alex, Charlie, Anonymous, Joshua, Arin, Sage, Marcel, Ahawk, Yehuda, Kevin, Evan, Shahin, Al Alami, Dale, Ethan, Gerr, Effy, Noam, Ron, Shtus, Mendel, Jared, Tim, Mystic Experiment, MM, Lenny, Justin, Joshua, Jorge, Wayne, Jason, Caroline, Yaakov, Daniel, Wodenborn, Steve, Collin, Justin, Mariana, Vic, Shaw, Carlos, Nico, Isaac, Frederick, David, Ben, Rodney, Charley, Jonathan, Chelsea, Curly Joe, Adam and Andre. Join them in supporting us: patreon: https://www.patreon.com/seekers paypal: https://www.paypal.com/donate?hosted_button_id=RKCYGQSMJFDRU

In today's episode, we're joined by Dr. Latt Mansor, a distinguished researcher and world-renowned expert in physiology and metabolism, holding a PhD from Oxford where he conducted pioneering research. Dr. Mansor serves as research lead for the wellness product brand, HVMN, where he oversees the company's initiatives and collaborations with universities and research institutions.He's made significant contributions in understanding the role of exogenous ketones, work which forms the basis of our conversation today. I've been using exogenous ketones since 2017, and the technology has improved vastly, starting as salts and moving to esters. Now, the best-of-the-best on the market is a diol.Dr. Latt explains the use and role of exogenous ketones in everything from lowering inflammation to supporting healing through a traumatic brain injury, Alzheimer's, and dementia; how exogenous ketones work in the body and their benefits; and why the United States government has contracts with him to provide energy to our elite men and women on the front line.I also share my own experience with ketones and how I'm using them, postpartum, to feel my best. I'm so impressed with how the technology has improved, how much better it tastes, how great you can feel, and all of the amazing benefits. If you'd like to try Ketone IQ, use the code KELLY for 20% off of your order with HVMN.We also cover…00:02:00 — How Ketones Impact Brain Function & Energy • Dr. Latt's journey to working in metabolism research• Endogenous ketones and exogenous ketones explained• Why the brain needs glucose to function• How the brain creates energy from ketones• The difference between ketone ester and ketone diol00:27:00 — Benefits of Ketosis & Using Ketones for Postpartum & Depression• What it feels like to be in ketosis• How Kelly used ketones pre-pregnancies• Read: Brain Energy by Chris Palmer • Mitochondria & Mental Illness: Finding Hope & Healing in Our Cells with Dr. Chris Palmer #250• Kentone diols for pregnancy and postpartum• The link between ketones, mitochondrial health, and improving depression• Use cases for ketones related to brain cognition and memory improvement00:43:00 — Metabolic Flexibility & Ketones' Role in Healing Brain Disease • Situations where Kelly recommends using exogenous ketones for clients• Dose recommendations • Metabolic flexibility and why it's important• How ketones influence our ability to have strong brain function later in life• How a ketogenic diet can help with brain diseases• Use cases for Ketone IQ in hospitals with traumatic brain injury patients• Running Through Hell: Enduring Ultrarunning & Boosting Mental Health · Lisa TamatiResources:• Website: hvmn.com (Use code KELLY for a 20% discount)• Instagram: @lattmansor• Instagram:

What are endogenous and exogenous technologies, and how can this framework help us bring our ideas to life? Join Modern Mantra founders Nick and Elijah as they catch up on the concepts that have been circulating for them recently. Elijah starts by sharing around his recent explorations with music and plant medicine. Find out how making music has deepened his connection with nature, and expanded his understanding of endogenous tools: our inbuilt technologies, such as the breath and the voice.Turning to the ‘exogenous' - our external, tangible technologies - what happens as we start visualizing the invisible? Nick discusses the tech that could change the landscape for healers, and envisions what becomes possible when our inner dimensions begin to synthesise with the digital scape.Tune in to get inspired by ancient wisdom, fresh ideas and new innovation for accessing your core essence, and unlocking the creative magic to start manifesting your visions into reality.Show notes:04:52 Tapping into Icaros, the frequencies of nature14:07 Endogenous and exogenous technologies20:16 The body as an interface: ancient practices for recentering25:46 Music making for intimacy with nature, self and others33:24 Digitally visualising the human energy field44:33 When modern science catches up with ancient wisdomThanks for listening! Follow us on YouTube, Instagram, TikTok or find us on LinkedIn! Join the ModernMantra.co mailing list here.

Commentary by Dr. Candice Silversides

You have to fast, do a lot of dietary interventions, or work out to make your body turn its own fat reserves into ketones. In ketogenesis, your liver has to convert fat stores, it takes a long time. You can get really good at it and get you natural ketones up in 18-24 hours. If you're a carb-eater, you're going to take multiple days, and you're going to get keto flu because your body has to readapt its enzymes and all of its metabolism to focus on being a fat burner. But if you can have a drinkable ketone, you skip that conversion step. So you can have something that you directly consume that gives you ATP but it's not protein, fat, or carbohydrate. - Geoffrey Woo Live Life Well from Sunrise to Sunset Save 20% with code "WELLNESSFORCE" on everyone's favorite Superfoods brand, ORGANIFI, including their Sunrise to Sunset Bundle and their Women's Power Stack that includes HARMONY + GLOW for true hormonal balance and great health radiating through your beautiful skin. Click HERE to order your Organifi today. Are You Stressed Out Lately? Take a deep breath with the M21™ wellness guide: a simple yet powerful 21 minute morning system that melts stress and gives you more energy through 6 science-backed practices and breathwork. Click HERE to download for free. Biohack Your Mind & Body with Plunge Ice Baths!Save $150 on your PLUNGE order with code "WELLNESSFORCE" As seen on Shark Tank, Plunge's revolutionary Cold Plunge uses powerful cooling, filtration, and sanitation to give you cold, clean water whenever you want it, making it far superior to an ice bath or chest freezer. *Review The WF Podcast & WIN $150 in wellness prizes! *Join The Facebook Group   Wellness + Wisdom Episode 549 Geoffrey Woo, entrepreneur, investor, and co-founder and Executive Chairman of H.V.M.N., joins Josh Trent on the Wellness + Wisdom podcast episode 549 to teach you how to achieve ketosis without fasting or a keto diet, and how ketones can help you quit coffee for good. Do you know the difference between endogenous and exogenous ketones? In this episode, you will learn why exogenous ketones are the ultimate physical biohack, and how they can help you maximize your performance, quit drinking coffee, and replace fasting and keto diet. 20% Off H.V.M.N. 20% off HVMN with code "JOSH" Get Your Fuel From Ketones Looking for a cleaner brain fuel? Just one daily serving of Ketone-IQ™️ will help you feel sharper, more focused, and ready to take on the day Ketones are nature's superfuel, proven to support energy, focus, endurance, and more. Developed alongside the U.S. military and top universities, Ketone-IQ™ delivers all those benefits in one drink. No caffeine, no sugar—just clean, on-demand energy for superior physical and cognitive performance. Optimal Blood Ketone Levels for 4 Hours Did you know that ketones provide the most benefits in a certain range? With Ketone-IQ™, you can stay at these levels for up to 4 hours — much longer than other drinkable ketones. Fueling with ketones takes you to a place where everything flows — a gentle, clean boost of energy without the jitters or racing heart. Built to support endurance and recovery, Ketone-IQ™️ is used by high performers of all types, from Navy SEALs and Tour de France cyclists to athletes in every major sport in the U.S. Each serving costs less than a cup of coffee! 20% off HVMN with code "JOSH" Listen To Episode 549 As Geoffrey Woo Uncovers: [01:30] Biohacking with Ketones H.V.M.N. - 20% off with code "JOSH" Geoffrey's background: how his parents left China and moved to the United States. 431 David Wolfe | Freedom Over Fear: Jing Energy, Detoxification & How To Have Balance Kevin Kelly What made him switch from computers to biohacking. The ancestral wisdom behind fasting. 365 Dr. Paul Saladino | Your Guide To The Carnivore Diet: The Myths of Eating Meat & Plants [16:45] The Purpose of H.V.M.N. + Fasting Experiments Why money was the driving force behind Geoffrey's business and why it switched to helping people. How the H.V.M.N. team experimented with 72-hour fasting. Jake Paul The Truman Show Why it's important to not give up when you fail and keep going. How the body produces ketones naturally. Why ketones help with brain injury recovery. [35:05] Endogenous vs. Exogenous Ketones How macronutrients support your health. The function of butyrate acid in a Ketone drink. Why H.V.M.N. is trying to make Ketone supplements affordable. 532 Molly Maloof MD: The Spark Factor | Biohacking For Women Micheal Brandt How ketosis increases HRV in sleep. Why sugar and protein trigger mTOR and ketones do not. Endogenous vs. exogenous ketones. Andrew Huberman What many people get wrong about ketones. Dr. Dan Engle [57:05] Ketone Stacking + How Ketones Work with Diabetes Ketone synergy stacking with ayahuasca. Why ketones don't require insulin to enter the system and work much faster than fat. Bulletproof Coffee Why people with diabetes should avoid ketones. H.V.M.N on Shark Tank How Geoffrey deals with negative outcomes and situations. [01:13:00] Spiritual Journey: Why We Need Something to Die For Identity struggles: why we need values and principles. Why Geoffrey loves books. Michael Pollan Why finding a core mission and building relationships with other people are two compounds of living well. 23andMe Why we owe it to our ancestors to heal. Power Quotes From The Show Exogenous Ketones "You hear about people bonking out when they're doing marathons or bike rides. You're eating sugar but at a certain point, your body doesn't digest the sugar quickly enough so you bonk out, and your muscles freak out. The way I look at exogenous ketones is that we want this specific signal to happen at this specific time that would not normally be achievable by a diet. It's a metabolism tool to turn fasting or keto diet on for you now while having other substrates." - Geoffrey Woo Glucose, Ketones + Ancestral Wisdom "A lot of early research saw that ketones were looking like a very good replacement for glucose. We don't just go brain-dead when we run out of stored glucose for glycogen. It's very clear that when we were hunter-gatherers, we were not just constantly having sugar bombs in our pockets. These people would do multi-day endurance hunts. In some sense, we almost forgot that ancestral wisdom." - Geoffrey Woo Plant Medicine Ceremony with Ketone Supplements "I've heard a very interesting combination synergy with ayahuasca plant medicine with ketones. There's fasting, purging, and a very clean diet. You're essentially getting the ketogenic state. In a plant ceremony, all these neurons are firing, you need energy, and you need substrate to fuel all that neurotransmitter release. Ketones are very efficient to fuel the power of all of those synapse firing." - Geoffrey Woo Links From Today's Show  H.V.M.N - 20% off with code "JOSH" 431 David Wolfe | Freedom Over Fear: Jing Energy, Detoxification & How To Have Balance Kevin Kelly 365 Dr. Paul Saladino | Your Guide To The Carnivore Diet: The Myths of Eating Meat & Plants Jake Paul The Truman Show 532 Molly Maloof MD: The Spark Factor | Biohacking For Women Micheal Brandt Andrew Huberman Dr. Dan Engle Bulletproof Coffee H.V.M.N on Shark Tank Michael Pollan 23andMe SaunaSpace - 10% off using code "JOSH10" Paul Chek: All Is God Shop the Wellness Force Media Store Organifi – Special 20% off to our listeners with the code ‘WELLNESSFORCE' breathwork.io SEED - Save 35% with the code "JOSH" BON CHARGE - Save 15% with the code "JOSH15" MANNA Vitality - Save 20% with the code "JOSH20" Mendi.io - Save 20% with the code "JOSH20" SpectraSculpt - Save 15% with "JOSH15" Cured Nutrition CBD - Save 20% with the CODE "WELLNESSFORCE" PLUNGE – Save $150 with the code “WELLNESSFORCE" LiftMode - Save 10% with the code "JOSH10" HVMN - Get 20% off your Ketone IQ order with the code "JOSH" MitoZen – Save 10% with the code “WELLNESSFORCE” Paleovalley – Save 15% on your ACV Complex with the code ‘JOSH' NOOTOPIA - Save 10% with the code "JOSH10" ActivationProducts – Save 20% with the code “WELLNESSFORCE” NEUVANA - Save 15% with the code “WELLNESSFORCE” SENSATE - Save $25 on your order with the code "JOSH25" DRY FARM WINES - Get an extra bottle of Pure Natural Wine with your order for just 1¢ ION - Save 15% off sitewide with the code ‘JOSH1KS' Feel Free from Botanic Tonics – Save 40% when you use the code ‘WELLNESS40′ Drink LMNT – Zero Sugar Hydration: Get your free LMNT Sample Pack, with any purchase BREATHE - Save 20% by using the code “PODCAST20” Essential Oil Wizardry: Save 10% with the code ‘WELLNESSFORCE' NEUROHACKER - Save 15% with the code "WELLNESSFORCE" ALIVE WATER - Save 33% on your first order with the code "JOSH33" M21 Wellness Guide Wellness + Wisdom Community Leave Wellness + Wisdom a review on Apple Podcasts Geoffrey Woo H.V.M.N Instagram Facebook Twitter About Geoffrey Woo Geoffrey Woo is an entrepreneur and investor. He is co-founder and Executive Chairman of H.V.M.N. and Archive. He is also a co-founder of Anti Fund. He has co-authored 5 US patents and 3 peer-reviewed scientific articles. He earned a BS with Honors and Distinction in Computer Science from Stanford University.

•Endogenous circadian rhythms are set for -24 hours and are tuned on a daily basis to exactly 24 hr through exposure to cues: Light, temperature and socialization. •Circadian rhythm disruption is strongly associated with increased rates of several types of cancer, elevated incidence of cardiovascular and metabolic disorders, as well as increased prevalence of behavioral and psychiatric disorders Learn more about your ad choices. Visit megaphone.fm/adchoices

Share this post with others: What happens when COVID meets BIND? What happens when someone in protracted benzodiazepine withdrawal gets long COVID? Does it set off a wave? Does it make their benzo symptoms worse? Tune in for answers and more. In today's episode, we explore COVID and benzodiazepine withdrawal (BIND). We also look at endogenous benzodiazepines, hear two benzo stories of success, and visit the launch of our new website and social media feeds. I hope you find it helpful. Podcast ID: BFP113 Chapters 0:00:00  INTRODUCTION0:03:10  Podcast Anniversary0:05:15  MAILBAG0:05:52  Endogenous Benzodiazepines0:07:21  Benzodiazepines in Potatoes0:09:44  BENZO SPOTLIGHT0:10:47  About the New Website0:12:48  Member Community on EA0:14:55  About Membership Tiers0:17:21  Our Handle / YouTube0:19:29  Social Media0:23:47  BENZO STORIES0:24:08  Ted's Story0:27:08  Judith's Story0:30:41  FEATURE: COVID and Benzos0:34:11  D's COVID Experience0:38:57  Jennifer: Could the vaccine be a trigger?0:40:33  Dan: COVID, Flu, and a Big Wave0:41:37  Jürg: COVID Setback?0:45:14  Annette: COVID Constriction0:46:36  Chuck: A Medical Perspective         0:49:11  Benzos and COVID Immunity0:50:13  Benzos and COVID Drugs0:51:12  Benzos and COVID Hospitalization0:52:11  Long COVID and BIND0:54:28  Long COVID Digestion Issues0:56:30  Neurological Effects of COVID0:58:53  COVID and Dysphagia (Swallowing)1:00:10  Long COVID Frequency1:00:53  My Theory / Summation1:01:58  Finding Hope1:04:46  CLOSING References The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Benzo Free of the resource or any recommendations or advice provided therein. RESOURCES BIND Symptoms. Easing Anxiety. https://easinganxiety.com/symptoms. COVID-19 (& Benzos). Benzodiazepine Information Coalition (BIC). https://www.benzoinfo.com/covid-19/. COVID-19: Long-term effects. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351. Long COVID or Post-COVID Conditions. Centers for Disease Control and Prevention (CDC). https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html. EA PODCAST EPISODES ON COVID Anxiety, Benzos, and a Virus. Episode 61. March 17, 2020. https://www.easinganxiety.com/post/anxiety-benzos-and-a-virus-bfp061. COVID and Benzos: Immunity, Vaccines, Symptoms. Episode 80. April 28, 2021. https://www.easinganxiety.com/post/covid-and-benzos-immunity-vaccines-symptoms-bfp080. EA VIDEOS ON COVID 10 Anxiety Tips for Dealing with Relationships during COVID. Video #20. September 24, 2020. https://www.easinganxiety.com/post/10-anxiety-tips-for-dealing-with-relationships-during-covid. 3 Basic Anxiety Tips amid COVID-19. Video #3. April 3, 2020. https://www.easinganxiety.com/post/3-basic-anxiety-tips-amid-covid-19. Anxiety and the Loss of Control During COVID-19. Video #5. April 11, 2020. https://www.easinganxiety.com/post/anxiety-and-the-loss-of-control-during-covid-19. Anxiety, Overwhelm, COVID & a Trip to Estes Park. Video #18. August 20, 2020. https://www.easinganxiety.com/post/anxiety-overwhelm-covid-a-trip-to-estes-park-vlog-7. Anxiety Rising: The Hidden Hardship of COVID-19. Video #10. May 20, 2020. https://www.easinganxiety.com/post/anxiety-rising-the-hidden-hardship-of-covid-19-vlog-1. REFERENCES Ashton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual. Avallone R, Zeneroli ML, Venturini I, Corsi L, Schreier P, Kleinschnitz M, Ferrarese C, Farina F, Baraldi C, Pecora N, Frigo M, Baraldi M. Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of patients with liver cirrhosis with and without overt encephalopathy. Gut. 1998 Jun;42(6):861-7. doi: 10.1136/gut.42.6.861. PMID: 9691927; PMCID: PMC1727144. https://www.

References Authentic Biochemistry Podcast Immunoepigenetics lectures XXIX-XXX1 Dr. Guerra's intermediary metabolism and bioenergetics lectures Nature. 2019 Jul; 571(7765): 403–407 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

http://www.CoachMikeD.com Episode 309 of Impact and Fulfillment w/ Coach Mike D dives into how "Exogenous" vs "Endogenous" systems and solutions work in your life. This is a MUST LISTEN!!!! So often we place our Peace in "Exogenous" Solutions/systems when it is more important for us to develop internal solutions to our major challenges and issues. Let me know what you think!!! Subscribe: Apple Podcasts: https://podcasts.apple.com/us/podcast/impact-and-fulfillment-with-coach-mike-d/id1230596918 Spotify: https://open.spotify.com/show/4oNGxgmdwaTOpWwdf1BGyR Youtube: https://www.youtube.com/@CoachMikeD Be Blessed, Well and Wise!!! Peace

Metabolic Health and optimal performance, support for brain injuries or those suffering from neurodegeneration. From insulin resistance to weightloss to optimising your speed and power output, we cover it all in this enlightening episode with Dr Latt Mansor.   What you will learn in this episode:   What are exogenous ketones and how do they differ from endogenous ketone  What are the benefits metabolically for using exogenous ketones What clinical research is currently being conducted with exogenous ketones and what are the results from studies so far Can exogenous ketone esters improve your athletic performance Do you need to be on a keto diet to experience benefits with exogenous ketone esters. Why are DARPA and the Department of Defence so interested in exogenous ketone esters How athletes and high powered executives  are using this to augment their physical and mental performance  What the future might hold for treating various illnesses with exogenous ketone esters. I have been fascinated with the keto diet, ketones salts and ketone esters for a number of years and have watched with interest this field evolve. I am super excited to announce I have now teamed up with H.V.M.N producers of theKetone-IQ™ to bring this incredible product to consumers downunder.   Having used it on myself and with my mum in her recovery I can personally attest to the extraordinary results both from an athletic performance and cognitive focus perspective as well as from a brain rehabilitation, metabolic health perspective and I am excited for the future with this,   Grab your Ketone-IQ™ here   Wishing you a very merry and healthy xmas and new year. Lisa      About Dr Latt Mansor   Dr. Latt Mansor holds a PhD in Physiology, Anatomy and Genetics from the University of Oxford, where his research focused on the metabolism of the type 2 diabetic heart in hypoxia. He also holds an M.A. (Columbia University) and B.Sc. (Hons) (University of Nottingham) in Biotechnology. He is a world expert in physiology and metabolism, and consults with elite sport, military, clinical and research organizations.   Although his education was primarily in health sciences, Latt always believed that collaborative efforts between science and business have more potential to create an impact in improving people's lives than each on its own.   Health Optimisation Consulting with Lisa  Are you struggling with a health issue and need someone who looks outside the square and someone  connected to some of the greatest science and health minds in the world? Then reach out to us at lisa@lisatamati.com, we can jump on a call to see if we are a good fit for you or visit  Lisa's Health Consulting If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at lisa@lisatamati.com.   Order Lisa's Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor   Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time.   What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today.   Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules   Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility   Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos   Ketone Products by Keto-Pro Exogenous Ketones developed by Nutritionist and Body Building champion Richard Smith. Keto-Pro BHB Exogenous Ketones –  250g   MORE BHB per gram than other MARKET LEADERS. During In-house testing, Keto-Pro BHB raised ketones quicker, higher and for longer than other market leaders. Grab your Ketones here.   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! You can also connect with Matty on his Website YOUR DNA 360 REPORT + ONE-ON-ONE CONSULTATION    Enjoyed This Podcast? If you did, subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can discover the benefits of an infrared sauna. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

John Chavez is the founder of DMT Quest, a nonprofit organization. He is the producer of the documentary DMT Quest. He is also author of the two volume set, Questions for the Lion Tamer: Delving Into the Mystery That Is DMT. His website is https://dmtquest.org/ Here he points out that DMT, the most powerful psychedelic … Continue reading "Endogenous DMT with John Chavez"

Why do we care for others? Why did morality evolve? Is unselfish behaviour possible in a Darwinian world? Patricia Churchland joins to discuss these topics with your host, Ilari Mäkelä. Author of Conscience: Origins of Moral Intuition, Patricia Churchland is an emerita professor of Philosophy at UC San Diego. Ilari and Professor Churchland discuss topics such as: Warm-bloodedness and morality Psychological egoism vs unselfish behaviour Neurobiology of care: Oxytocin, cannabinoids, opioids Elements of morality: How much of morality is about care, vs problem-solving, cooperation, and social learning? Churchland's criticism of Western moral philosophy Neurophilosophy: is studying the brain all that useful? Free will: does studying the brain show that free will does not exist? Technical terms mentioned: Endothermy (i.e. warm-bloodedness) Cortex Oxytocin, vasopressin Endogenous opioids and cannabinoids Utilitarian ethics Kantian ethics (i.e. deontology) Metta meditation Vitalism Names mentioned: Christophe Boesch (chimpanzee adoption) Peggy Mason (helping behaviour in rats) Sue Carter (oxytocin and stress) David Hume & Adam Smith Mencius (early Confucian philosopher) [For Ilari's article on Mencius, see An Empirical Argument for Mencius' Theory of Human Nature] The Dalai Lama (H.H. the 14th) Simon Blackburn (contemporary Cambridge philosopher) Dan Bowling (placebo and oxytocin) Olivia Goldhill (review of Conscience for the New York Times) Lidija Haas (review of Conscience for the Harper Magazine) Other scholars to follow (Churchland's recommendations) Topics in this interview Frans de Waal Owen Flanagan Philosophy & neuroscience more generally Nick Lane (genetics and evolution) Ann-Sophie Barwich (neurophilosophy of smell) Gregory Berns (soon to appear on the podcast) Ned Block (philosophy of cognition)

You might have been skeptical if you had heard about ketones and their benefits a few years ago. After all, ketones are a by-product of fat metabolism, and who wants to think about fat when trying to lose weight?  However, we're continuing to learn more and more about ketones, and it is becoming clear that they offer several benefits for athletes and people looking to improve their health.  Dr. Latt Mansor is a world expert in physiology and metabolism and has spent many years studying the role of ketones in human health. He has consulted with elite sports military clinical and research organizations worldwide. And he is passionate about helping people understand the role that ketones can play in preventing chronic diseases such as diabetes and cardiovascular disease. One of the things that Dr. Mansor has found is that ketones can be incredibly beneficial for weight loss. In fact, he has seen average weight losses of 20 pounds in his patients using ketone supplements such as Ketone IQ. He has also found that ketones can help suppress appetite, making losing weight easier. In this podcast, we cover:  What is the difference between exogenous and endogenous ketones? Why do our bodies want to stay in a state of balance Discovering how ketones work in low oxygen environments (hypoxia) The difference between ketone esters and ketone IQ Exogenous vs. endogenous ketones The overall benefits of ketones And so much more. What is the difference between exogenous and endogenous ketones? Endogenous ketones are produced by the body, while exogenous ketones are those that come from an external source.  Exogenous ketones have become popular lately because they can help people lose weight and improve their athletic performance. How ketones help the brain in a low oxygen environment (hypoxia) In our talk with Dr Latt he said, "The original rationale for ketones was that they could be used as an energy source by the brain, bypassing the blood-brain barrier. And what we know of ketone metabolism is that it produces ATP, which is the energy our cells need to function. We wanted to see if ketones could help mitigate cognitive decline in low-oxygen environments. And what we found was that in a group of people given ketones, there was a flattening of the cognitive decline typically seen in hypoxia. This was promising enough for us to run a bigger study looking at different tasks and populations. And while we're still learning more about how ketones affect cognition and oxygen metabolism, so far the results are promising and suggest that ketones could be a valuable tool in protecting cognitive function in low-oxygen environments." This podcast will help you understand more about ketones and their potential to help people in low oxygen environments and their overall benefit on metabolism, aging, cognition and more. Dr Latt's cutting-edge work on ketones is very exciting. You don't want to miss this. Episode Resources: Hvmn.com - use our custom code AHP for 10% offTwitter: @lattmansor Instagram: @lattmansor

How do medical marijuana and pediatric palliative care fit together? In this episode, Sarah and Dan seek some clarity about cannabis, interviewing two experts on the topic, Dr. Bonni Goldstein and Dr. Dustin Sulak. Listen to learn more about the endocannabinoid system and the impact that this much-maligned medicine has on it and on patients, often in ways we're only beginning to understand.Resources mentioned in the episode and recommended by the guests:Society of Cannabis Clinicians: https://www.cannabisclinicians.orgDr. Sulak's book: https://wwnorton.com/books/9780393714180Dr. Goldstein's book: https://www.canna-centers.com/cannabis-is-medicine/Dr. Sulak's website with free patient education: https://www.healer.comDr. Sulak's physician-developed hemp products: https://healercbd.com/

Today, my guest is Eric Tung, Founder and CEO of Themelio Labs, the company behind Themelio, a public blockchain that enables open, secure, and resilient decentralized apps. Themelio is pitched as a radically simple, stable, and long-term foundation that can power a vast and diverse ecosystem. Themelio plans to play a fundamental and ubiquitous role in the security infrastructure of a new and decentralized Internet, much like how IP, “immutable” since 1983, still underpins Internet communication. Themelio's design is firmly centered around decoupling the blockchain from user-facing applications. Themelio does one thing — provide robust low-level functionality critical to secure decentralized apps — and strives to do it very well. An example is Mel, an independent, stable-value cryptocurrency that anyone can freely use. Inspired by previous blockchains like Bitcoin and Ethereum, Themelio nonetheless takes a very different design approach: radical immutability inspired by the Internet's architecture. Eric spent parts of his childhood in Canada and China, where he was born. His mother home-schooled him while they lived in Beijing to keep the Chinese Communist Party propaganda to a minimum. Yet as China ramped up its Great Firewall to block outside Internet from coming into the country, Eric rebelled and built Geph, a virtual private network that could get around the Chinese firewall. He did this when he was 12, and Geph is still used today in China and Iran. At 14, Tung was accepted into the University of Waterloo, where Ethereum inventor Vitalik Buterin was also a student and creator of Themelio. This new blockchain protocol strips out higher-level functionality to focus on the shared trusted layer of truth. We discuss various topics, including the internet protocol stack, rethinking blockchain, the importance of endogenous trust, paradigm shifts, and much more. We begin our conversation by discussing Eric's background and what led him down the crypto rabbit hole. Eric explains how he started Geph and became interested in cryptography. We discuss why freedom tools and privacy-preserving protocols may be even more critical in the future. Our conversation transitions to discussing how the internet is structured and the various protocols that make up the internet. We pivot to discuss Themelio. We discuss how Eric and his team have reimagined how a blockchain should work by modeling it after the internet. We discuss how they created revolutionary non-fiat stablecoin. We also touch on how the killer feature of blockchains has always been endogenous trust and why that is important. We finish our conversation by discussing how to unlock the true potential of blockchain technology and what applications will drive mass adoption of blockchain technology. Please enjoy my conversation with Eric Tung. -- This podcast is powered by Blockworks. For exclusive content and events that provide insights into the crypto and blockchain space, visit them at https://blockworks.co

In this episode, Taylor interviews Dr. Latt Mansor about his work with ketones and the different effects they can have on our bodies. As both point out throughout the episode, any benefit of ketones depends on the individual– both the way their genetic makeup reacts to ketones and their level of activity. Starting off the episode with a more clinical approach, Latt breaks down and defines what ketones are, the process of ketogenesis, and what conditions must be met for our bodies to enter ketosis.As the episode progresses, the discussion centers around endogenous ketones versus exogenous ketones and the benefits of each. Using a ketogenic diet, the body takes advantage of endogenous ketones produced, yielding benefits like weight loss and a boost in energy. On the flip side, using an exogenous ketone source, such as Ketone-IQ™, may be suited more for a generally healthy individual that seeks to fuel their mental clarity, metabolic health, or athletic performance. The episode wraps up with Latt discussing his work with the Special Forces to combat the effects of hypoxia through the consumption of exogenous ketones.Tune in to learn more!Key Quotes“I think at the end of the day, we only have one life. We've got to enjoy our life as much as we can, but also take care of it– so by being on a ketogenic diet [it] is us taking care of our health, our wellbeing.” –Dr. Latt Mansor“If you don't like what you're eating every single day, that could be doing more harm than good because of the mental aspect of it.” –Taylor MorganKey Timestamps[7:25] – Episode start with Dr. Latt Mansor;[11:55] – Defining ketones, ketosis, and ketogenesis;[14:22] – Endogenous versus Exogenous ketones;[19:16] – Benefits of a ketogenic diet (endogenous ketones);[22:42] – The correlation between mental wellbeing and physiology;[24:51] – How exogenous ketones act quickly through the blood-brain barrier;[29:23] – Benefits of using exogenous ketones (Ketone-IQ™);[32:09] – Using ketones, casein, or collagen before sleep and relaxation;[39:18] – Latt's study with the Special Forces (ketones against hypoxia);[43:30] – The effects of diet and levels of physical activity on body composition;[50:35] – Focus on the quality and timing of meals;[52:58] – The importance of using trial and error to determine what works for your body;[57:48] – Who Ketone-IQ™ is and isn't for;[1:01:16] – Episode wrap upShow SponsorsHVMN Ketones (CODE: CAPTAINMORGAN10): https://tinyurl.com/5awbrv4wNootropics from Nootopia: www.nootopia.com/taylorLambs EMF Blocking Clothing (CODE: CAPTAINMORGAN): https://tinyurl.com/2p8jn86hWaveBlock EMF Protection (CODE: CAPTAINMORGAN): https://tinyurl.com/3a4ukk48Connect with Dr. Latt MansorInstagram: https://www.instagram.com/lattmansor/?hl=enConnect with TaylorInstagram: https://tinyurl.com/2p92c3wzInstagram: https://tinyurl.com/55k552naWebsite: https://tinyurl.com/mrxzv7ff

Upon sequencing the human genome, scientists were surprised to find that it is composed of about 8% viral sequence. These fossils are relics of ancient primate infections where retroviruses incorporated into the chromosome and became part of the human lineage. While these viral elements have contributed positively to speciation and development of specific human traits, they also have the capacity to become pathogenic. Dr. Advinda Nath is the Clinical Director of the National Institute of Neurological Disorders and Stroke. He joins Talking Biotech to share his experiences, knowledge and predictions in this exciting, emerging area of research.  # COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab's world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

Nutrient timing involves the purposeful consumption of all types of nutrients at various times throughout the day to favorably impact the adaptive response to acute and chronic exercise. Old idea: you need to deplete glycogen for carb loading supercompensation to work. New idea: you only need to reduce training training and eat high carbs for 3-4 days (8-12g/kg/day). Old idea: consuming fructose or carbohydrate close to competition can interfere with optimum performance. New idea: if carbohydrate consumption causes gut distress don't consume them close to competition Here are the ISSN guidelines for nutrient timing, which we discuss in the podcast. Endogenous glycogen stores are maximized by following a high-carbohydrate diet (8–12 g of carbohydrate/kg/ day [g/kg/day]). If rapid restoration of glycogen is required (< 4 h of recovery time) then the following strategies should be considered: a) aggressive carbohydrate refeeding (1.2 g/kg/h) with a preference towards carbohydrate sources that have a high (> 70) glycemic index b) the addition of caffeine (3–8 mg/kg) c) combining carbohydrates (0.8 g/kg/h) with protein (0.2–0.4 g/kg/h) Extended (> 60 min) bouts of high intensity (> 70% VO2max) exercise challenge fuel supply and fluid regulation, thus carbohydrate should be consumed at a rate of ~30–60 grams of carbohydrate/h in a 6–8% carbohydrate- electrolyte solution (6–12 fluid ounces) every 10–15 min throughout the entire exercise bout, particularly in those exercise bouts that span beyond 70 min. When carbohydrate delivery is inadequate, adding protein may help increase performance, ameliorate muscle damage, promote euglycemia and facilitate glycogen resynthesis. Carbohydrate ingestion throughout resistance exercise (e.g., 3–6 sets of 8–12 repetition maximum [RM] using multiple exercises targeting all major muscle groups) has been shown to promote euglycemia and higher glycogen stores. Consuming carbohydrate solely or in combination with protein during resistance exercise increases muscle glycogen stores, ameliorates muscle damage, and facilitates greater acute and chronic training adaptations. Meeting the total daily intake of protein, preferably with evenly spaced protein feedings (approximately every 3 h during the day), should be viewed as a primary area of emphasis for exercising individuals. Ingestion of essential amino acids (EAA; approximately 10 g)either in free form or as part of a protein bolus of approximately 20–40 g has been shown to maximally stimulate muscle protein synthesis (MPS). Pre- and/or post-exercise nutritional interventions (carbohydrate + protein or protein alone) may operate as an effective strategy to support increases in strength and improvements in body composition. However, the size and timing of a pre-exercise meal may impact the extent to which post-exercise protein feeding is required. Post-exercise ingestion (immediately to 2-h post) of high-quality protein sources stimulates robust increases in MPS. In non-exercising scenarios, changing the frequency of meals has shown limited impact on weight loss and body composition, with stronger evidence to indicate meal frequency can favorably improve appetite and satiety.  Ingesting a 20–40 g protein dose (0.25–0.40 g/kg body mass/dose) of a high-quality source every three to 4 h appears to most favorably affect MPS rates when compared to other dietary patterns and is associated with improved body composition and performance outcomes. Consuming casein protein (~ 30–40 g) prior to sleep can acutely increase MPS and metabolic rate throughout the night without influencing lipolysis. —- To Download The Tailored Trainer and Gain Unlimited Access To Expert Programming, Sign Up Here: Tailored Trainer Sign Up Page To Get Your Questions Answered On The Podcast: Ask Us Here! 1st Phorm Supps: To Get FREE PRIORITY SHIPPING and Support The Podcast, Get Your Supplements At 1st Phorm Using Our Link: www.1stphorm.com/tailoredcoachingmethod To Apply For Coaching: Click Here Download 1 (or ALL) Of Our FREE GUIDES: www.tailoredcoachingmethod.com/guides Private Podcast FB Community: Be Part Of The Conversation and Community, RIGHT HERE. —- Extra Content For You:  How We Coach: Client Case Study Article Top 4 Podcast Episodes: - Nutritional Periodization - Nutrition FAQ - Training FAQ - My Story ---- Social Links: Blog – http://www.tailoredcoachingmethod.com/blog
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