Podcasts about Bax

Bax and Nagle 08-14-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 08-13-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 08-12-25 by Rock 102 Morning Show Podcasts

BUFFALO, NY - August 13, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.” In this study, led by first author Jassy Mary S. Lazarte and corresponding author Nazarius S. Lamango from Florida A&M University College of Pharmacy and Pharmaceutical Sciences, researchers investigated a new class of compounds called polyisoprenylated cysteinyl amide inhibitors (PCAIs) as a potential treatment for aromatase inhibitor (AI) therapy resistant breast cancer. Aromatase inhibitors are a common treatment for estrogen receptor-positive (ER+) breast cancer, but many patients eventually develop resistance, leaving fewer therapeutic options. The study focused on a PCAI compound called NSL-YHJ-2-27, which was tested in long-term letrozole-treated breast cancer cells (LTLT-Ca), an experimental model of AI therapy resistance. NSL-YHJ-2-27 activated two major signaling pathways, MAPK and PI3K/AKT. Although these pathways typically support cancer cell survival, their overstimulation by PCAIs led to increased oxidative stress, damaging the cells and inducing cell death by apoptosis. The compound also reduced levels of RAC1 and CDC42, proteins involved in maintaining cell shape and movement. These alterations resulted in cytoskeletal disruption and reduced structural integrity, making the cancer cells more vulnerable and less capable of spreading. Importantly, the effects of NSL-YHJ-2-27 persisted after the compound was removed, suggesting long-term control over AI resistant cancer cells may be possible. “PCAIs inhibited cell proliferation and colony formation by 95% and 74%, respectively, increased active caspase 7 and BAX 1.5-fold and 56%, respectively. NSL-YHJ-2-27 (10 μM) induced LTLT-Ca spheroid degeneration by 61%.” As a new class of targeted molecules, PCAIs represent an innovative approach distinct from traditional endocrine therapies. Their ability to affect multiple cellular mechanisms simultaneously makes them promising candidates for future drug development. Overall, this study presents a promising new approach for treating AI therapy-resistant breast cancer. By targeting cellular pathways that support survival and mobility, PCAIs like NSL-YHJ-2-27 could provide a novel strategy to manage advanced or resistant forms of the disease. Further research, including in vivo studies and clinical trials, will be essential to confirm these findings and evaluate their therapeutic potential. DOI - https://doi.org/10.18632/oncotarget.28759 Correspondence to - Nazarius S. Lamango - nazarius.lamango@famu.edu Video short - https://www.youtube.com/watch?v=8xQEilloO9Q Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28759 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Bax and Nagle 08-11-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 08-07-25 by Rock 102 Morning Show Podcasts

Bax & Nagle 8-6-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 08-05-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 08-04-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-31-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-29-05 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-30-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-28-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-23-25 by Rock 102 Morning Show Podcasts

Bax and Nagles 07-21-25 by Rock 102 Morning Show Podcasts

Bax and Nagles 07-22-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-17-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-16-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-15-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-14-25 by Rock 102 Morning Show Podcasts

What's up, dudes? It's the Hallmark Ornament Premiere, so I've got the Anthony Caruso from ‘Tis the Podcast and Vinnie Brezinsky from Huey and Bax here to talk the 1989 Hallmark Dreambook—all 32 pages of it! That's right! We get into baubles and finials and cameos! Oh my! We talk our personal collections and which ones from 1989 we own! Spoilers: I have the entire Norman Rockwell cameo set from 80-89! Or do I? Guess you'll have to listen to find out! Peanuts, Paddington, and Rodney Reindeer ornaments make appearances, too! And have you joined the Hallmark Keepsake Ornament Collector's Club yet? Have you decorated your wreaths and garlands with keepsake ornaments? Do you even own a pair of white satin gloves? So bust out your tree and ornaments, put on the Time Life Treasury of Christmas, and travel back to 1989 with this episode!‘Tis the PodcastFB: @tisthepodTwitter: @tisthepodIG: @tisthepodcastGive us a buzz! Send a text, dudes!Check us out on Facebook, Twitter, Instagram, Totally Rad Christmas Mall & Arcade, Teepublic.com, or TotallyRadChristmas.com! Later, dudes!

Bax and Nagle 07-02-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 07-01-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-30-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-27-25 by Rock 102 Morning Show Podcasts

Bax to the Future - Bax, Spaniard, and Nuno talk about ex's coming back into the picture, grapes, and dirty pastors.  Come out to the Coach House on July 18th and watch Shadow and the Thrill. Hang out with the Hooligans from TheLife.  See y'all there.  www.TheLifePodcast.net TheHooliganCorp@gmail.com

Bax and Nagle 06-26-25 by Rock 102 Morning Show Podcasts

Bax and NAGLE 06-25-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-23-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-24-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-20-25 by Rock 102 Morning Show Podcasts

Dodging raindrops - Bax, Spaniard and Nuno escape from the containment ....although a few mistakes were made.  We forgot to post the show :) www.TheLifePodcast.net TheHooliganCorp@gmail.com

Rocket Man- Bax, Spaniard, Nuno, and Scoops discuss the past week's activities.  Bax launched into outer space and took a nap on the rings of Saturn.  Yup! Way out there.  www.TheLifePodcast.net TheHooliganCorp@gmail.com  

Bax and Nagle 06-19-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-18-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-17-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-16-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-13-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-12-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-11-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-10-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-09-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-06-25 by Rock 102 Morning Show Podcasts

Guess who? - Bax, Spaniard, and Nuno get into disturbing news out of the music world.  Bax knew it all along.  There's a lot going on, but isn't there always.....a lot going on.  It's a whole thing. www.TheLifePodcast.net TheHooliganCorp@gmail.com  

Bax and Nagle 06-05-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-04-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-03-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 06-02-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 05-30-25 by Rock 102 Morning Show Podcasts

Bax and Nagle 05-28-25 by Rock 102 Morning Show Podcasts