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Join HRS Board Member Prashanthan Sanders, MBBS, PhD, FHRS (University of Adelaide) as he discusses this exciting paper, presented at Heart Rhythm 2025. He is joined in the Heart Rhythm Tv Studio in San Diego, California by Louise Segan, MBBS, MPH (Alfred Health), and Takanori Yamaguchi, MD, PhD (Saga University). This discussion took place on-site at Heart Rhythm 2025. https://www.hrsonline.org/education/TheLead https://www.heartrhythmjournal.com/article/S1547-5271(25)01245-7/fulltext Host Disclosure(s): P. Sanders: Honoraria/Speaking/Consulting: Boston Scientific, Abbott Medical, Research: Boston Scientific, Abbott, Medtronic, Becton Dickinson, CathRx, Pacemate, Kalyan Technologies, Ceryx Medical, Biosense Webster, Inc., Hello Alfred, Abbott Medical Membership on Advisory Committees: Pacemate, Medtronic PLC, Boston Scientific, CathRx, Abbott Medical Contributor Disclosure(s): T. Yamaguchi: Honoraria/Speaking/Consulting: Abbott Japan, Biotronik, Boston Scientific, Abbott Medical, Japan Medtronic, Inc., Daiichi Sankyo, Novartis, Japan Lifeline, Nihon Kohden, Bayer Healthcare Pharmaceuticals Japan, Boehringer Ingelheim L. Segan: Nothing to disclose.
Prashanthan Sanders, MBBS, PhD, FHRS, University of Adelaide is joined by Jenish Shroff, MBBS, MD, Australian National University, and Pugazhendhi Vijayaraman, MD, FHRS, Geisinger Heart Institute, to discuss this first-in-human feasibility study evaluated a novel helix-based leadless pacemaker (LPCSP) designed to achieve left bundle branch area pacing (LBBAP), a capability current LPs lack. The device was temporarily implanted via the internal jugular vein into the interventricular septum in 14 patients, with successful implantation in 10. Electrical performance metrics, including pacing threshold, R-wave amplitude, and impedance, were within acceptable clinical ranges. LBBAP capture was achieved in 5 patients, with no serious device-related adverse events in 85.7% of cases. The study supports the acute safety and feasibility of LPCSP for conduction system pacing. https://www.hrsonline.org/education/TheLead https://www.heartrhythmjournal.com/article/S1547-5271(25)02378-1/fulltext Host Disclosure(s): P. Sanders: Honoraria/Speaking/Consulting: Boston Scientific, Abbott Medical, Research: Boston Scientific, Abbott, Medtronic, Becton Dickinson, CathRx, Pacemate, Kalyan Technologies, Ceryx Medical, Biosense Webster, Inc., Hello Alfred, Abbott Medical Membership on Advisory Committees: Pacemate, Medtronic PLC, Boston Scientific, CathRx, Abbott Medical Contributor Disclosure(s): P. Vijayaraman: Honoraria/Speaking/Consulting: Biotronik, Boston Scientific, Abbott Medical, Medtronic, Inc. Research (Contracted Grants for PIs and Named Investigators only): Medtronic Fellowship Support: Medtronic J. Shroff: Nothing to disclose.
Join host Prashanthan Sanders, MBBS, PhD, FHRS, and episode guests Jason G. Andrade, MD, FHRS, and Melanie Gunawardene, MD, as they discuss Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation. This discussion was recorded in person at EHRA 2025 in Vienna, Austria. The article under discussion was presented at EHRA 2025 and simultaneously published in the New England Journal of Medicine. https://www.hrsonline.org/education/TheLead https://www.nejm.org/doi/full/10.1056/NEJMoa2502280 Host Disclosure(s): P. Sanders: Honoraria/Speaking/Consulting: Boston Scientific, Abbott Medical Research: Boston Scientific, Abbott, Medtronic, Becton Dickinson, CathRx, Pacemate, Kalyan Technologies, Ceryx Medical, Biosense Webster, Inc., Hello Alfred, Abbott Medical; Membership on Advisory Committees: Pacemate, Medtronic PLC, Boston Scientific, CathRx, Abbott Medical Contributor Disclosure(s): M. Gunawrdene: Honoraria/Speaking/Consulting: Farapulse, Abbott Medical, Boston Scientific, Medtronic, Biotronik, Luma Vision, Bristol Myers Squibb J. Andrade: Honoraria/Speaking/Consulting: Boston Scientific, Medtronic, Inc., Biosense Webster, Inc.
Join host and Digital Education Chair Prashanthan Sanders, MBBS, PhD, FHRS, as he discusses this article from Nature with guests Anand N Ganesan, MBBS, PhD, and Tina Baykaner, MD, MPH. This trial was also presented as a late-breaking clinical trial at Heart Rhythm 2024. https://www.hrsonline.org/education/TheLead https://www.nature.com/articles/s41591-025-03517-w Host Disclosure(s): P. Sanders: Honoraria/Speaking/Consulting: Boston Scientific, Abbott Medical Research: Boston Scientific, Abbott, Medtronic, Becton Dickinson, CathRx, Pacemate, Kalyan Technologies, Ceryx Medical, Biosense Webster, Inc., Hello Alfred, Abbott Medical; Membership on Advisory Committees: Pacemate, Medtronic PLC, Boston Scientific, CathRx, Abbott Medical Contributor Disclosure(s): A. Ganesan: Honoraria/Speaking/Consulting: Biosense Webster, Inc. T. Baykaner: Honoraria/Speaking/Consulting: Medtronic, Pacemate, Volta Medical, iRhythm Technologies; Research: NIH This episode is worth 0.25 ACE credits. If you want credit for listening to this episode, please visit the episode page on HRS365: https://www.heartrhythm365.org/URL/TheLeadEpisode99
In this episode Britta Mulderrig discusses her wide-ranging and industrious career — including using internships to land her first job with the Tampa Bay Lightning, navigating times of challenging growth at Uber, and the perils of being the only woman in the room. She also dispenses advice for building resilience, keeping a to-do list to bolster productivity, and making a positive impact — through your job and beyond.Britta Mulderrig (Guest): https://www.linkedin.com/in/brittamulderrig/Zoia Kozakov (Host): https://www.linkedin.com/in/zoia-kozakov/About WIN: Women in Innovation: https://www.womenininnovation.co/Brand Copy by Nicole Beckley See acast.com/privacy for privacy and opt-out information.
Our first video and audio podcast! This is a jammed pack episode 1 hour in length focused on the Future of Retail, covering:The New NormalRetail Winners during COVID lockdownNaked Wines https://www.nakedwines.com/Digital ExperiencesNear Street https://near.st/Hello Alfred https://www.helloalfred.com/Hello Alfred & Unilever, creating a new Third or Fourth Space in retail.Video Link: https://www.youtube.com/watch?v=oPBQCYf0ueMInsider Trends: https://www.insider-trends.com/
Welcome to the second episode of The Idealists. (formerly Grit & Grace) where host, Melissa Kiguwa interviews entrepreneur Emma Toshack. She is a law school dropout, former chef, and Harvard MBA… in that order. Now she's the Founder of Nomadica, a craft canned wine company found in different Whole Foods & music festivals across the United States. Inc. Magazine calls her the millennial breaking all the rules of the wine industry… well, let's find out for ourselves!-Emma's Bio:Emma's story starts in Sydney - where she dropped out of law school to start a restaurant and fell in love with food. After a fire shut it down she went on to ride horses for a year before finally finishing law school, but her love of food & wine was there to stay. After college she joined The Boston Consulting Group, where she worked for 3.5 years, making too many excel spreadsheets & wearing too many suits. She moved to Boston to get her MBA at Harvard Business School; there she co-founded Startup Lockdown and Hello Alfred before moving to Los Angeles to join Snapchat in 2015. She left 18 months later to launch Nomadica with Kristin, and the sommelier curated wine experience she'd been dreaming of for years was born. Emma lives in Los Angeles with her girlfriend; she loves art, her dog Apollo, and supporting the Los Angeles LGBTQ community.
The show opens for the first time from our new Greenwich, Connecticut studio with a look at how big tech has been helping to fight the Coronavirus outbreak. Next, Alex looks at security concerns that may come with government access to location data for quarantine purposes and how platforms stocks have been doing in the downturn. The show closes with a continued look at how the Coronavirus outbreak is impacting startups and analysis of the 2017 deal between home services provider Hello Alfred and luxury real estate firm Related.
In this episode, Kandice Herndon explores how focusing on an outcome can take a to-do list that gives us a case of the blah's and instead produce that feeling of ta-da! The spark for this podcast comes from the wisdom of Marcela Sapone, co-founder of Hello Alfred, and her Forbes post, “ Stop Thinking in Tasks and To-Dos. Start Thinking in Outcomes.”Forbes:https://www.forbes.com/sites/marcelasapone/2018/07/24/stop-thinking-in-tasks-and-to-dos-start-thinking-in-outcomes/#31e1f7885522Hello Alfred: https://www.helloalfred.com/ About Cinnamon SparksCinnamon Sparks is a facilitation services company that exists to help our clients create growth by serving their customers and community more effectively. We dig in with you to take an honest look at where your organization stands by involving the team members of your choosing in discovery. Then, we will break down big priorities into specific projects, engaging your team to generate ideas and ultimately a plan to get them done!Email -kandice@cinnamonsparks.comOfficial Website -https://cinnamonsparks.comLinkedIn - https://www.linkedin.com/company/cinnamon-sparks
Episode Notes Learn English with Two Old Men. The Two Old Men are back! This is a two-part episode. An episode of mystery and a very long story by Geoffrey! Support us Support us on Patreon to help us create more funny and interesting material:https://www.patreon.com/chuckleEnglishHow to use See the website (www.chucklenglish.com) on how to learn with the podcast.Transcript Alfred: Welcome to Two Old Men in a Shed. I’m still waiting for Geoffrey. He’s late again. At least, I haven’t got one of his strange friends knocking on the door this time. Alfred: Oh dear, I hope it’s not Doris again! Come in! Geoffrey: Yes, Yes, Hello Alfred! It’s me Geoffrey. Alfred: Thank god for that. Geoffrey: Thank god for what? Alfred: That it’s you! Geoffrey: Yes. Of course it’s me! Who else would it be? Alfred: Well, do you remember last week? You arrived quite late. Also, your friend was here and I had to listen to her. Geoffrey: My friend was here? What friend are you talking about? Alfred: Oh dear! Doris, she was here with me alone and we recorded a podcast while we were waiting for you. Geoffrey: Doris was here? Yes, yes. I seem to recall finding her here. You need to be careful with Doris. She might be 85, but she is like a Burmese tiger! Alfred: Like a Burmese tiger? Whatever do you mean? Geoffrey: She’s a naughty girl. Leave her alone with someone and she’ll soon be jumping on top of them! Alfred: Thank god that didn’t happen! Geoffrey: Yes, yes. She didn’t try to kiss you? She’s done it to all the old men at the retirement home! How strange! She must only like older men! Alfred: Older men? Geoffrey: Yes, that must be it. I remember on the way home, on the bus, she literally jumped on top of me. She stuck her tongue down my throat. Alfred: Please! No more details! Geoffrey: Of course, she had to remove her false teeth first; she usually puts them in her pocket where she keeps her sweets and tissues. Alfred: I’m going to vomit. Please, don’t tell me anything else happened! Geoffrey: Remember, I’m a married man. Of course I didn’t do anything else. Alfred: You saying that you are a married man is a sentence that I will never get used to. Geoffrey: Thank you! Anyway, when I managed to get her off me, she couldn’t find her false teeth! Alfred: I imagine they were probably in your pockets! You’ve got allsorts in there. Geoffrey: Yes, yes. Well everything except biscuits these days! My wife still hides them! Alfred: I hope you wife didn’t find the false teeth. That would be hell of an explanation, to explain why you have another woman’s false teeth in there. Geoffrey: They weren’t in my pocket! Alfred: Ah! Did you find them? Geoffrey: Well, we started looking everywhere. In my pockets, in her handbag, she even started to look down my trousers for a long time, but we couldn’t find them! Alfred: Is that the story? Geoffrey: No! Let me finish! Alfred: I thought you had stopped! Geoffrey: I was trying to pause to give dramatic effect. Alfred: Wow! I’m not used to it. Usually, you just talk and talk and never stop! You’re really starting to get into this podcast aren’t you? Geoffrey: This pod...what? Alfred: Oh dear! Anyway, where did you find the false teeth? Geoffrey: Well, that is the funny thing. Alfred: I expect that it is. Geoffrey: We had all of the passengers looking for the teeth. Even the bus driver was on his knees looking around. Alfred: Did you find them? Geoffrey: Do you know what? Alfred: Can you just finish the story. Geoffrey: Yes, yes. The story, of course I’ll finish it. But do you know what? Alfred: Dear me! What Geoffrey? Geoffrey: I thought that before I met my wife... Alfred: Is that the wife that we haven’t mentioned in a long time? Geoffrey: Yes, yes, her! Alfred: Ok, Go on... Geoffrey: Before I met my wife, I thought I was a very clean gentleman! Alfred: I don’t know what to laugh about more there, the fact you still have a wife, that you thought you were clean or that you consider yourself to be a gentleman! Geoffrey: There’s no need to be rude. Alfred: I’m sorry Alfred. Geoffrey: Good! Well, when my wife showed me that I had a cupboard under the sink, I couldn’t believe it! The cupboard was full of old cleaning products! It was astonishing! Alfred: Why? Geoffrey: Well, I’ve never bought cleaning products in my life! How did they get there under my sink? Alfred: You probably bought them by accident. Geoffrey: By accident?! Me? Well, probably! Although to be honest, whenever I’ve needed to give something a quick clean, I’ve always used a bit of whisky, water and my toothbrush. Alfred: Your toothbrush and whisky? That does explain a lot. Geoffrey: Yes, yes... like what? Alfred: Well, your house always smells like whiskey even the garden. Also, I would describe the colour of your teeth as a mixture of whisky and dirt. Geoffrey: But the important thing is that they are my own teeth! Well all except the front one...or two...or three. But most are my own teeth! Alfred: Ok. I have no idea where we are in this story. Geoffrey: Yes! Well, after my wife cleaned my kitchen, I couldn’t believe the difference! I thought my kitchen walls were brown! I thought it was a style to match the wooden cupboards. After my wife... Alfred: whose name is...? Geoffrey: I said her name on the other podcast. After my wife cleaned them I nearly had to wear those dark glasses in the morning to protect them against the shiny white walls. Alfred: Dark glasses? You mean sunglasses, don’t you? Geoffrey: Yes, those. Alfred: By the way, how is your wife? Did you ever find out whether she was cheating or not? Geoffrey: My wife, I don’t really want to speak about her right now. Alfred: I’m sorry Geoffrey. Anyway, back to the story. Geoffrey: Yes! The story! Yes, yes, yes! What story? Alfred: Wow. At least he is not Doris! The story about the false teeth on the bus. Geoffrey: Yes. Well if you stop distracting me, I’ll finish the story. Alfred: Distracting you? Geoffrey: Yes, you are always interrupting! Alfred: Me? Interrupting? Geoffrey: Yes! Right, we were all on the floor of the bus looking for the false teeth. What I wanted to say is that I couldn’t believe how dirty it was down there! We found everything; so much chewing gum, hair clips and even a false leg! Alfred: A false leg? Geoffrey: Yes! Now who would leave a false leg on a bus? Wouldn’t they realise that they got on the bus with two legs and left with only one? It’s not the type of thing you can miss easily! Alfred: You’d be surprised! All it takes is a couple of glasses of wine, and the next moment you’ve got a false leg missing! Geoffrey: Don’t be silly. To be continued....Support Chuckle English by donating to their Tip Jar: https://tips.pinecast.com/jar/chuckle-english
Imagine a time-expanding, space-creating home-operating system for your life. Content is integrated into human-centered technology combined with hands-on hospitality to create the home of the future and redefine modern city living. Head of Communications & Brand Katherine Barna shares how this may be the future of city living, and how Hello Alfred is thinking about the role of content in that reality.
If you're following the companies I'm talking with, then you're seeing a trail success being blazed right before your eyes. In this podcast episode, I recap companies I've featured previously including Reonomy, Remarkably, and of course Avail. Of the companies I've featured, they've gone on to raise over $200M since they were featured on Tech Nest. I also put my guest list I'd like to make happen in 2020 including guests from Compass, NFX, VTS, Inc., Hello Alfred, and Clutter.Not finished recording new episodes for 2019 yet, but getting amped up for the interviews I can hopefully bring y'all in 2020! BTW, if you're not yet on our Insiders email list, you can join, visit http://technest.io to find the link.
Feliks Banel on the little known Fort Whitman on Goat Island // Rep. Pramila Jayapal on investigating the president // Hanna Scott on solitary confinement for juveniles in King County // Dose of Kindness -- a principal who make sure his students have everything they need // Mike Salk on NFL instant replay/ the 2019 Mariners // Riisa Conklin from the Freeway Park Assn on the proposal to lid I-5 in Seattle // Sam Dingley from "Hello Alfred," a modern butler service
Marcela Sapone and Jessica Beck created the idea for Hello Alfred on a piece of paper with stick figure drawings while attending Harvard Business School. They got their start by slipping postcards under doors in Boston to promote their services, and later decided they wanted to cancel the business for multiple reasons. But it was too late, their customers were already hooked, leaving these co-founders with no choice but to press on. On this episode, Sapone and Beck discuss how they built Hello Alfred from the ground up, working every job in the company, how they turned down multiple investors for not supporting their human-centered vision and the craziest thing someone has asked their Alfred to do. Congratulations to our No Limits Entrepreneur of the Week: Sashee Chandran, Founder of Tea Drops Find out more: https://www.myteadrop.com/ Want to be a featured NLEOTW? Know someone who should? Send your nominations toNoLimitswithRJPodcast@Gmail.com Don
Featured interview with Hello Alfred CEO Marcela Sapone. Ernest Savage reports on efforts by the National Domestic Workers Alliance to create good jobs in sectors that haven't traditionally had them. Dorian Warren casts a skeptical eye on the mad rush by one city after another to attract Amazon's new headquarters.
One criticism of the gig economy is that it takes advantage of employees. Companies like Uber or Lyft classify their employees as independent contractors, disqualifying them from benefits. But Hello Alfred, a personal butler service, started by thinking about work differently. When they launched, they made their workforce all eligible for health insurance, 401Ks, and paid family leave. In this episode, co-founders Marcela Sapone and Jessica Beck explain how their model works and scales.
Marcela Sapone, chief exec and co-founder of Hello Alfred, tells Andrew Hill, FT management editor, how she coped with the pressure of maintaining momentum after a successful launch. See acast.com/privacy for privacy and opt-out information.
Jessica Beck started Hello Alfred while still at Harvard Business School; within a year she and cofounder Marcela Sapone had secured $10.5 million in Series A funding and won the tech scene’s best-known pitch competition. And oh yeah: their product is a modern-day butler service.
At the New York stop of the Inside Intercom World Tour, Forbes Senior Editor, Steve Bertoni, hosts a panel of local startup founders. The chat is all about what makes great product, and panelists include Lindsay Boyajian, CMO at Augment; Mike Boufford, VP of Engineering at Greenhouse; Christian Bjelland, Founding Team of Hello Alfred.
Series A - Startup Stories, host Laurel Touby (mediabistro founder)
Laurel sits down with the CEO of Hello Alfred, Marcela Sapone, to dive into the details behind this high growth startup that allows everyone to experience the benefits of having their own butler. In this episode we discuss: - How to turn your idea into a real company by getting your first customer - When trust is at the core of your product, how do you ensure you're building that trust with your customers - W2 vs 1099: why Alfred chose to classify employees as W2 (it's better for business in the long run) - Deferring growth to focus on unit economics in order to make a sustainable company - Using focused experimentation to continually learn and grow
Marcela shares her personal evolution as CEO and the rituals that inspire Hello Alfred's self-sustaining culture of learning and transparency.
The on-demand economy is a hit with consumers. Uber, Lyft, Homejoy, and other companies provide a growing number of convenient services. But there's a heated debate about how they treat their workers. Should they be classified as independent contractors or full-time employees who qualify health care, disability and other benefits? Richard and Jim's guest is Marcela Sapone, CEO of Hello Alfred, a startup company that dispatches workers to co-ordinate laundry, cleaning, grocery shopping and other chores. She has useful tips for freelancers and outspoken views about how employees should be treated by companies, communities and the government. See acast.com/privacy for privacy and opt-out information.