Podcast appearances and mentions of mark socinski

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Best podcasts about mark socinski

Latest podcast episodes about mark socinski

ReachMD CME
Advancing ALK Inhibition Into Early-Stage NSCLC: Integrating Biomarker-Driven Therapies to Reduce Recurrence Risk Post Resection

ReachMD CME

Play Episode Listen Later Dec 20, 2024


CME credits: 0.25 Valid until: 20-12-2025 Claim your CME credit at https://reachmd.com/programs/cme/advancing-alk-inhibition-into-early-stage-nsclc-integrating-biomarker-driven-therapies-to-reduce-recurrence-risk-post-resection/27056/ This animated podcast explores the evolving role of ALK inhibitors in managing early-stage non-small cell lung cancer (NSCLC). Dr. Mark Socinski discusses molecular profiling as a cornerstone for identifying ALK fusion–positive cases and highlights clinical data from pivotal trials. He also addresses the challenges of treatment adherence, toxicity management, and the importance of surrogate endpoints in early-stage disease. The discussion concludes with key takeaways on integrating targeted therapies into standard care for early-stage resectable NSCLC.=

Breakfast Club
October 26, 2022 - Dr Mark Socinski & Tiffany

Breakfast Club

Play Episode Listen Later Mar 8, 2024 7:25


October 26, 2022 - Dr Mark Socinski & Tiffany

mark socinski
Becker’s Healthcare Podcast
Dr. Mark Socinski, Executive Director (Thoracic Cancer) & Medical Oncologist at AdventHealth

Becker’s Healthcare Podcast

Play Episode Listen Later Aug 1, 2023 20:07


This episode features Dr. Mark Socinski, Executive Director (Thoracic Cancer) & Medical Oncologist at AdventHealth. Here, he discusses his background & work with AdventHealth, his new research recently published in JAMA that finds having an inflammatory side effect with advanced non-small cell lung cancer (NSCLC) might not be such a bad thing, how this research can help with survival rates, if this may extend into other areas of cancer, and more.

ReachMD CME
Keeping Pace in Lung Cancer Personalizing Treatment in NSCLC: Locally Advanced Disease (Stage IIIB/C)

ReachMD CME

Play Episode Listen Later Apr 17, 2023


CME credits: 0.25 Valid until: 17-04-2024 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-personalizing-treatment-in-nsclc-locally-advanced-disease-stage-iiibc/15139/ The clinical value of adding immunotherapy together with chemoradiation in locally advanced non-small cell lung cancer (NSCLC) has been evident since 2017. This concept has been extended through the emergence of key clinical trials, such as KEYNOTE-799, which includes both squamous and non-squamous subsets. In fact, the coalescence of chemoradiation and immunotherapy has begun to not only push up overall survival, but to also improve cure rates with manageable toxicity. But as the landscape rapidly changes, it becomes increasingly difficult to link evolving data to clinical practice. Join Drs. Mark Socinski and Kristin Higgins as they parse the key trials and offer insights that will help you provide better care, and possibly more hope, for your patients with locally advanced NSCLC.=

disease treatments pace keynote locally cme lung cancer personalizing rmd nsclc pulmonary medicine reachmd cme/ce oncology and hematology pathology and lab medicine prova education mark socinski stage iiib pathology and laboratory medicine
ReachMD CME
Keeping Pace in Lung Cancer: Personalizing Treatment in NSCLC: Early-Stage Disease (Stage I-IIIa)

ReachMD CME

Play Episode Listen Later Apr 17, 2023


CME credits: 0.25 Valid until: 17-04-2024 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-personalizing-treatment-in-nsclc-early-stage-disease-stage-i-iiia/15138/ The optimal management of non-small cell lung cancer (NSCLC) has fundamentally changed. Targeted agents, mono and combination immunotherapy, and immunochemotherapy options continue to emerge. You also need to factor in new and investigational neoadjuvant and adjuvant regimens. So how do you determine which patients will benefit most within this new landscape of options? Join Drs. Mark Socinski and Patrick Forde as they address these questions and provide a measure of order in the chaos.=

Breakfast Club
October 26, 2022 - Dr Mark Socinski & Tiffany

Breakfast Club

Play Episode Listen Later Oct 26, 2022 7:25


October 26, 2022 - Dr Mark Socinski & Tiffany

mark socinski
ReachMD CME
Personalizing NSCLC: The Optimal Applicability of NGS and Liquid Biopsy

ReachMD CME

Play Episode Listen Later Jul 15, 2022


CME credits: 0.25 Valid until: 15-07-2023 Claim your CME credit at https://reachmd.com/programs/cme/personalizing-nsclc-the-optimal-applicability-of-ngs-and-liquid-biopsy/13834/ There are new targeted therapies that are now approved for the treatment of advanced non-small cell lung cancer. Dr. Mark Socinski & Dr. Marie Suga discuss evolving diagnostic approaches and best practices for selecting the right therapy for patients with NSCLC.

optimal cme personalizing rmd biopsies nsclc applicability liquid biopsy pulmonary medicine reachmd cme/ce oncology and hematology pathology and lab medicine prova education mark socinski pathology and laboratory medicine
ReachMD CME
Personalizing NSCLC: The Optimal Applicability of NGS and Liquid Biopsy

ReachMD CME

Play Episode Listen Later Jul 15, 2022


CME credits: 0.25 Valid until: 15-07-2023 Claim your CME credit at https://reachmd.com/programs/cme/personalizing-nsclc-the-optimal-applicability-of-ngs-and-liquid-biopsy/13834/ There are new targeted therapies that are now approved for the treatment of advanced non-small cell lung cancer. Dr. Mark Socinski & Dr. Marie Suga discuss evolving diagnostic approaches and best practices for selecting the right therapy for patients with NSCLC.

optimal cme personalizing rmd biopsies nsclc applicability liquid biopsy pulmonary medicine reachmd cme/ce oncology and hematology pathology and lab medicine prova education mark socinski pathology and laboratory medicine
ReachMD CME
Keeping Pace in Lung Cancer: Guidelines and the Future Direction of Immunotherapy in NSCLC

ReachMD CME

Play Episode Listen Later Dec 30, 2021


CME credits: 0.25 Valid until: 30-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-guidelines-and-the-future-direction-of-immunotherapy-in-nsclc/13165/ The therapeutic landscape for the first-line treatment of non-driver metastatic NSCLC has become complex and, in some cases, controversial. Based on PD-L1 status, do you know which patients should receive immune checkpoint inhibitor (ICI) monotherapy and when ICI should be combined with chemotherapy? Join Drs. Mark Socinski and Edward Garon as they focus on the intricacies associated with making these therapeutic choices, while also looking at future immunotherapeutic opportunities in the neoadjuvant and adjuvant settings.

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ReachMD CME
Keeping Pace in Lung Cancer: Clinical Case Challenges in NSCLC

ReachMD CME

Play Episode Listen Later Dec 30, 2021


CME credits: 0.25 Valid until: 30-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-clinical-case-challenges-in-nsclc/13181/ With the availability of more immunotherapies for the management of first-line metastatic NSCLC, PD-L1 status takes on greater importance in determining which approach is best for each patient. Follow along as Dr. Mark Socinski and Dr. Benjamin Levy discuss the factors they use when considering either an immuno-monotherapy or immunotherapy plus chemotherapy approach, and how they monitor for and manage immunotherapy-related adverse events.

challenges pace clinical cme lung cancer rmd nsclc clinical pharmacology pd l1 pulmonary medicine reachmd cme/ce benjamin levy oncology and hematology global oncology academy pathology and lab medicine prova education mark socinski pathology and laboratory medicine
ReachMD CME
Keeping Pace in Lung Cancer: Guidelines and the Future Direction of Immunotherapy in NSCLC

ReachMD CME

Play Episode Listen Later Dec 30, 2021


CME credits: 0.25 Valid until: 30-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-guidelines-and-the-future-direction-of-immunotherapy-in-nsclc/13165/ The therapeutic landscape for the first-line treatment of non-driver metastatic NSCLC has become complex and, in some cases, controversial. Based on PD-L1 status, do you know which patients should receive immune checkpoint inhibitor (ICI) monotherapy and when ICI should be combined with chemotherapy? Join Drs. Mark Socinski and Edward Garon as they focus on the intricacies associated with making these therapeutic choices, while also looking at future immunotherapeutic opportunities in the neoadjuvant and adjuvant settings.

direction pace guidelines ici cme lung cancer immunotherapy rmd nsclc clinical pharmacology pd l1 pulmonary medicine reachmd cme/ce oncology and hematology global oncology academy pathology and lab medicine prova education mark socinski pathology and laboratory medicine
ReachMD CME
Keeping Pace in Lung Cancer: Integration of Immune Checkpoint Inhibitors as Initial Therapy for Advanced Disease

ReachMD CME

Play Episode Listen Later Dec 30, 2021


CME credits: 0.25 Valid until: 30-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-integration-of-immune-checkpoint-inhibitors-as-initial-therapy-for-advanced-disease/13147/ Medical innovation in the treatment of lung cancer is at an all-time high. However, the gap between recent developments and their adoption into clinical practice continues to expand for community oncologists as the plethora of scientific and clinical data for the treatment of NSCLC rapidly emerges. Dr. Mark Socinski and Dr. Sandip Patel go through the selection and management of immune checkpoint inhibitors for patients with advanced NSCLC who do not have an actionable mutation.

ReachMD CME
Keeping Pace in Lung Cancer: Integration of Immune Checkpoint Inhibitors as Initial Therapy for Advanced Disease

ReachMD CME

Play Episode Listen Later Dec 30, 2021


CME credits: 0.25 Valid until: 30-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-integration-of-immune-checkpoint-inhibitors-as-initial-therapy-for-advanced-disease/13147/ Medical innovation in the treatment of lung cancer is at an all-time high. However, the gap between recent developments and their adoption into clinical practice continues to expand for community oncologists as the plethora of scientific and clinical data for the treatment of NSCLC rapidly emerges. Dr. Mark Socinski and Dr. Sandip Patel go through the selection and management of immune checkpoint inhibitors for patients with advanced NSCLC who do not have an actionable mutation.

Project Oncology®
Keeping Pace in Lung Cancer: Integration of Immune Checkpoint Inhibitors as Initial Therapy for Advanced Disease

Project Oncology®

Play Episode Listen Later Dec 30, 2021


Host: Mark Socinski, MD Guest: Sandip Patel, MD Medical innovation in the treatment of lung cancer is at an all-time high. However, the gap between recent developments and their adoption into clinical practice continues to expand for community oncologists as the plethora of scientific and clinical data for the treatment of NSCLC rapidly emerges. Dr. Mark Socinski and Dr. Sandip Patel go through the selection and management of immune checkpoint inhibitors for patients with advanced NSCLC who do not have an actionable mutation.

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Project Oncology®
Keeping Pace in Lung Cancer: Clinical Case Challenges in NSCLC

Project Oncology®

Play Episode Listen Later Dec 30, 2021


Host: Mark Socinski, MD Guest: Benjamin Levy, MD With the availability of more immunotherapies for the management of first-line metastatic NSCLC, PD-L1 status takes on greater importance in determining which approach is best for each patient. Follow along as Dr. Mark Socinski and Dr. Benjamin Levy discuss the factors they use when considering either an immuno-monotherapy or immunotherapy plus chemotherapy approach, and how they monitor for and manage immunotherapy-related adverse events.

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ReachMD CME
Keeping Pace in Lung Cancer: Clinical Case Challenges in NSCLC

ReachMD CME

Play Episode Listen Later Dec 30, 2021


CME credits: 0.25 Valid until: 30-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-clinical-case-challenges-in-nsclc/13181/ With the availability of more immunotherapies for the management of first-line metastatic NSCLC, PD-L1 status takes on greater importance in determining which approach is best for each patient. Follow along as Dr. Mark Socinski and Dr. Benjamin Levy discuss the factors they use when considering either an immuno-monotherapy or immunotherapy plus chemotherapy approach, and how they monitor for and manage immunotherapy-related adverse events.

challenges pace clinical cme lung cancer rmd nsclc clinical pharmacology pd l1 pulmonary medicine reachmd cme/ce benjamin levy oncology and hematology global oncology academy pathology and lab medicine prova education mark socinski pathology and laboratory medicine
ReachMD CME
Keeping Pace in Lung Cancer: Applying the Right Therapy to the Right Patient in RET-Positive NSCLC

ReachMD CME

Play Episode Listen Later Dec 17, 2021


CME credits: 0.25 Valid until: 17-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-applying-the-right-therapy-to-the-right-patient-in-ret-positive-nsclc/13130/ With an expanding arena of available selective RET inhibitors and more data being released on emerging therapies, the landscape for patients with RET-positive metastatic NSCLC is evolving rapidly. Join Drs. Mark Socinski and Justin Gainor as they review the importance of molecular testing in every patient, as well as when to initiate the use of selective RET-inhibitors across multiple lines of therapy. Did we mention you should be testing every patient? Tune in to make sure you're identifying everyone who can benefit from these newer therapies.

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ReachMD CME
Keeping Pace in Lung Cancer: Applying the Right Therapy to the Right Patient in RET-Positive NSCLC

ReachMD CME

Play Episode Listen Later Dec 17, 2021


CME credits: 0.25 Valid until: 17-12-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-applying-the-right-therapy-to-the-right-patient-in-ret-positive-nsclc/13130/ With an expanding arena of available selective RET inhibitors and more data being released on emerging therapies, the landscape for patients with RET-positive metastatic NSCLC is evolving rapidly. Join Drs. Mark Socinski and Justin Gainor as they review the importance of molecular testing in every patient, as well as when to initiate the use of selective RET-inhibitors across multiple lines of therapy. Did we mention you should be testing every patient? Tune in to make sure you're identifying everyone who can benefit from these newer therapies.

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Project Oncology®
Keeping Pace in Lung Cancer: Applying the Right Therapy to the Right Patient in RET-Positive NSCLC

Project Oncology®

Play Episode Listen Later Dec 17, 2021


Host: Mark Socinski, MD Guest: Justin Gainor With an expanding arena of available selective RET inhibitors and more data being released on emerging therapies, the landscape for patients with RET-positive metastatic NSCLC is evolving rapidly. Join Drs. Mark Socinski and Justin Gainor as they review the importance of molecular testing in every patient, as well as when to initiate the use of selective RET-inhibitors across multiple lines of therapy. Did we mention you should be testing every patient? Tune in to make sure you're identifying everyone who can benefit from these newer therapies.

positive therapy patients pace ret lung cancer rmd nsclc reachmd cme/ce oncology and hematology global oncology academy pathology and lab medicine prova education mark socinski pathology and laboratory medicine
Medical Industry Feature
An Expert Interview for 2L SCLC: A Look Into the Patient Journey

Medical Industry Feature

Play Episode Listen Later Dec 16, 2021


Host: Jennifer Caudle, DO Guest: Mark Socinski, MD Dr. Mark Socinski from the AdventHealth Cancer Institute in Florida joins Dr. Jennifer Caudle to discuss a patient profile in the treatment of relapsed small cell lung cancer to help us better understand the burden of this disease and how to approach treating patients in the second-line setting with treatment options like ZEPZELCA.

Project Oncology®
Keeping Pace in Lung Cancer – All About Antiangiogenics and TKIs: Current Roles and Future Directions in EGFR-Mutant NSCLC

Project Oncology®

Play Episode Listen Later Nov 30, 2021


Host: Mark Socinski, MD Guest: Edward B. Garon, MD, MS In the treatment of EGFR-mutated advanced non-small cell lung cancer (NSCLC), when is an EGFR TKI not enough? Answer: When you don't have all of the information. Digging deeper into the specific EGFR mutations has led to advances in the dual blockade of VEGF and EGFR in the frontline setting. Join Drs. Mark Socinski and Edward Garon as they discuss the evolving role of EGFR and VEGF blockade based on clinical trial data. Find out how you can have an immediate impact on your patients by making targeted treatment decisions based on specific oncogenic driver mutations in NSCLC. Be sure to keep up with our experts because making the right choice is more critical than ever.

ReachMD CME
Keeping Pace in Lung Cancer – All About Antiangiogenics and TKIs: Current Roles and Future Directions in EGFR-Mutant NSCLC

ReachMD CME

Play Episode Listen Later Nov 30, 2021


CME credits: 0.25 Valid until: 30-11-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-all-about-antiangiogenics-and-tkis-current-roles-and-future-directions-in-egfr-mutant-nsclc/13019/ In the treatment of EGFR-mutated advanced non-small cell lung cancer (NSCLC), when is an EGFR TKI not enough? Answer: When you don't have all of the information. Digging deeper into the specific EGFR mutations has led to advances in the dual blockade of VEGF and EGFR in the frontline setting. Join Drs. Mark Socinski and Edward Garon as they discuss the evolving role of EGFR and VEGF blockade based on clinical trial data. Find out how you can have an immediate impact on your patients by making targeted treatment decisions based on specific oncogenic driver mutations in NSCLC. Be sure to keep up with our experts because making the right choice is more critical than ever.

ReachMD CME
Keeping Pace in Lung Cancer – How Would You Treat? Case-Based Learning in EGFR-Mutant NSCLC

ReachMD CME

Play Episode Listen Later Nov 30, 2021


CME credits: 0.25 Valid until: 30-11-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-how-would-you-treat-case-based-learning-in-egfr-mutant-nsclc/13067/ FLAURA and RELAY have changed the landscape of treatment in EGFR-mutant advanced non-small cell lung cancer (NSCLC). But how do know which patients will benefit from these important advances in our knowledge of treating these cancers in the first and subsequent lines of therapy? Join Drs. Mark Socinski and John Heymach as they examine a patient case and discuss the “art” of treatment selection and sequencing of therapy. They also dive into recent advances in the dual blockade of antiangiogenics and TKIs in the frontline setting. Tune in to keep up!

ReachMD CME
Keeping Pace in Lung Cancer – How Would You Treat? Case-Based Learning in EGFR-Mutant NSCLC

ReachMD CME

Play Episode Listen Later Nov 30, 2021


CME credits: 0.25 Valid until: 30-11-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-how-would-you-treat-case-based-learning-in-egfr-mutant-nsclc/13067/ FLAURA and RELAY have changed the landscape of treatment in EGFR-mutant advanced non-small cell lung cancer (NSCLC). But how do know which patients will benefit from these important advances in our knowledge of treating these cancers in the first and subsequent lines of therapy? Join Drs. Mark Socinski and John Heymach as they examine a patient case and discuss the “art” of treatment selection and sequencing of therapy. They also dive into recent advances in the dual blockade of antiangiogenics and TKIs in the frontline setting. Tune in to keep up!

ReachMD CME
Keeping Pace in Lung Cancer – All About Antiangiogenics and TKIs: Current Roles and Future Directions in EGFR-Mutant NSCLC

ReachMD CME

Play Episode Listen Later Nov 30, 2021


CME credits: 0.25 Valid until: 30-11-2022 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-in-lung-cancer-all-about-antiangiogenics-and-tkis-current-roles-and-future-directions-in-egfr-mutant-nsclc/13019/ In the treatment of EGFR-mutated advanced non-small cell lung cancer (NSCLC), when is an EGFR TKI not enough? Answer: When you don't have all of the information. Digging deeper into the specific EGFR mutations has led to advances in the dual blockade of VEGF and EGFR in the frontline setting. Join Drs. Mark Socinski and Edward Garon as they discuss the evolving role of EGFR and VEGF blockade based on clinical trial data. Find out how you can have an immediate impact on your patients by making targeted treatment decisions based on specific oncogenic driver mutations in NSCLC. Be sure to keep up with our experts because making the right choice is more critical than ever.

Project Oncology®
Keeping Pace in Lung Cancer – How Would You Treat? Case-Based Learning in EGFR-Mutant NSCLC

Project Oncology®

Play Episode Listen Later Nov 30, 2021


Host: Mark Socinski, MD Guest: John V. Heymach, MD, PhD FLAURA and RELAY have changed the landscape of treatment in EGFR-mutant advanced non-small cell lung cancer (NSCLC). But how do know which patients will benefit from these important advances in our knowledge of treating these cancers in the first and subsequent lines of therapy? Join Drs. Mark Socinski and John Heymach as they examine a patient case and discuss the “art” of treatment selection and sequencing of therapy. They also dive into recent advances in the dual blockade of antiangiogenics and TKIs in the frontline setting. Tune in to keep up!

Oncology Peer Review On-The-Go
4: OncView Podcast: Front-Line Management of Extensive-Stage SCLC

Oncology Peer Review On-The-Go

Play Episode Listen Later Jun 28, 2021 27:42


As part of the OncView video series, CancerNetwork spoke with Mark Socinski, MD, of the AdventHealth Cancer Institute in Orlando, Florida about updates in the management of extensive-stage small cell lung cancer (ES-SCLC). Socinski touched on a number of important aspects of treating this disease, including the existing standards of care, treatment challenges, immunotherapy, IMpower 133 trial, and more. Don't forget to subscribe to the "Oncology Peer Review On-The-Go" podcast wherever you get your podcasts.

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Project Oncology®
Keeping Pace: Advances in First-Line Therapy for RET Fusion-Positive NSCLC

Project Oncology®

Play Episode Listen Later Aug 24, 2020


Host: Mark A. Socinski, MD Guest: Alexander Drilon, MD There are now multiple biomarker-defined patient subgroups in advanced non-small cell lung cancer (NSCLC), including RET rearrangements, and there is growing evidence that treatment with targeted therapies has significant clinical outcomes. In response to current rapid changes in the field of NSCLC, Drs. Mark Socinski and Alexander Drilon discuss the biology of RET fusion and how to translate the latest recommendations for targeted therapies into clinical practice.

Project Oncology®
Keeping Pace: Advances in RET Fusion-Positive NSCLC

Project Oncology®

Play Episode Listen Later Aug 24, 2020


Host: Mark A. Socinski, MD Guest: Alexander Drilon, MD There are now multiple biomarker-defined patient subgroups in advanced non-small cell lung cancer (NSCLC), including RET rearrangements, and there is growing evidence that treatment with targeted therapies has significant clinical outcomes. In response to current rapid changes in the field of NSCLC, Drs. Mark Socinski and Alexander Drilon discuss the biology of RET fusion and how to translate the latest recommendations for targeted therapies into clinical practice. Since this CME activity has been published the FDA has approved a new treatment for adults with metastatic RET fusion-positive non-small cell lung cancer. To learn more about this approval, please visit the FDA.gov: FDA approves pralsetinib for lung cancer with RET gene fusions

positive fda pace fusion drs advances ret cme rmd nsclc pulmonary medicine reachmd cme/ce oncology and hematology socinski global oncology academy prova education mark socinski mark a socinski
ReachMD CME
Keeping Pace: Advances in RET Fusion-Positive NSCLC

ReachMD CME

Play Episode Listen Later Aug 24, 2020


CME credits: 0.25 Valid until: 24-08-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-advances-in-ret-fusion-positive-nsclc/11784/ There are now multiple biomarker-defined patient subgroups in advanced non-small cell lung cancer (NSCLC), including RET rearrangements, and there is growing evidence that treatment with targeted therapies has significant clinical outcomes. In response to current rapid changes in the field of NSCLC, Drs. Mark Socinski and Alexander Drilon discuss the biology of RET fusion and how to translate the latest recommendations for targeted therapies into clinical practice.

ReachMD CME
Keeping Pace: Advances in RET Fusion-Positive NSCLC

ReachMD CME

Play Episode Listen Later Aug 24, 2020


CME credits: 0.25 Valid until: 24-08-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-advances-in-ret-fusion-positive-nsclc/11784/ There are now multiple biomarker-defined patient subgroups in advanced non-small cell lung cancer (NSCLC), including RET rearrangements, and there is growing evidence that treatment with targeted therapies has significant clinical outcomes. In response to current rapid changes in the field of NSCLC, Drs. Mark Socinski and Alexander Drilon discuss the biology of RET fusion and how to translate the latest recommendations for targeted therapies into clinical practice. Since this CME activity has been published the FDA has approved a new treatment for adults with metastatic RET fusion-positive non-small cell lung cancer. To learn more about this approval, please visit the FDA.gov: FDA approves pralsetinib for lung cancer with RET gene fusions

ReachMD CME
Keeping Pace: Advances in First-Line Therapy for EGFR-mutated NSCLC

ReachMD CME

Play Episode Listen Later Aug 7, 2020


CME credits: 0.25 Valid until: 07-08-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-lung-cancer-advances-first-line-therapy-egfr-mutated-nsclc/11773/ Advances in treatment and new insights into the biology of epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) have led to the development of treatments that significantly extend overall survival. In this discussion, Drs. Mark Socinski and Helena Yu cover the latest scientific and clinical data on the emerging role of targeted therapies in EGFR mutation-positive NSCLC.

ReachMD CME
Keeping Pace: Advances in First-Line Therapy for EGFR-mutated NSCLC

ReachMD CME

Play Episode Listen Later Aug 7, 2020


CME credits: 0.25 Valid until: 07-08-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-lung-cancer-advances-first-line-therapy-egfr-mutated-nsclc/11773/ Advances in treatment and new insights into the biology of epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) have led to the development of treatments that significantly extend overall survival. In this discussion, Drs. Mark Socinski and Helena Yu cover the latest scientific and clinical data on the emerging role of targeted therapies in EGFR mutation-positive NSCLC.

Project Oncology®
Keeping Pace: Advances in First-Line Therapy for EGFR-mutated NSCLC

Project Oncology®

Play Episode Listen Later Aug 7, 2020


Host: Mark A. Socinski, MD Guest: Helena Yu, MD Advances in treatment and new insights into the biology of epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) have led to the development of treatments that significantly extend overall survival. In this discussion, Drs. Mark Socinski and Helena Yu cover the latest scientific and clinical data on the emerging role of targeted therapies in EGFR mutation-positive NSCLC.

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Project Oncology®
Keeping Pace: Advances in First-Line Therapy for EGFR-mutated NSCLC

Project Oncology®

Play Episode Listen Later Aug 7, 2020


Host: Mark A. Socinski, MD Guest: Helena Yu, MD Advances in treatment and new insights into the biology of epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) have led to the development of treatments that significantly extend overall survival. In this discussion, Drs. Mark Socinski and Helena Yu cover the latest scientific and clinical data on the emerging role of targeted therapies in EGFR mutation-positive NSCLC.

therapy pace drs advances rmd first line egfr mutated nsclc pulmonary medicine reachmd cme/ce oncology and hematology socinski global oncology academy prova education mark socinski mark a socinski
ReachMD CME
Keeping Pace: The Use of Immunotherapy in Mutation-Positive Non-Small Cell Lung Cancer

ReachMD CME

Play Episode Listen Later Jul 15, 2020


CME credits: 0.25 Valid until: 15-07-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-lung-cancer-use-immunotherapy-mutation-positive-non-small-cell-lung-cancer/11723/ Advanced non-small cell lung cancer (NSCLC) remains incurable; however, advances in treatment and new insights into the molecular pathogenesis of the disease have led to the development of treatments that significantly extend overall survival. This discussion between Drs. Mark Socinski and Gilberto de Lima Lopes reviews the emerging scientific and clinical data on the role of immunotherapy in mutation-positive NSCLC. Tune in to discover how these therapeutics can benefit your patients.

ReachMD CME
Keeping Pace: The Use of Immunotherapy in Mutation-Positive Non-Small Cell Lung Cancer

ReachMD CME

Play Episode Listen Later Jul 15, 2020


CME credits: 0.25 Valid until: 15-07-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-lung-cancer-use-immunotherapy-mutation-positive-non-small-cell-lung-cancer/11723/ Advanced non-small cell lung cancer (NSCLC) remains incurable; however, advances in treatment and new insights into the molecular pathogenesis of the disease have led to the development of treatments that significantly extend overall survival. This discussion between Drs. Mark Socinski and Gilberto de Lima Lopes reviews the emerging scientific and clinical data on the role of immunotherapy in mutation-positive NSCLC. Tune in to discover how these therapeutics can benefit your patients.

Project Oncology®
Keeping Pace: The Use of Immunotherapy in Mutation-Positive Non-Small Cell Lung Cancer

Project Oncology®

Play Episode Listen Later Jul 15, 2020


Host: Mark A. Socinski, MD Guest: Gilberto de Lima Lopes Junior, MD, MBA, FAMS Advanced non-small cell lung cancer (NSCLC) remains incurable; however, advances in treatment and new insights into the molecular pathogenesis of the disease have led to the development of treatments that significantly extend overall survival. This discussion between Drs. Mark Socinski and Gilberto de Lima Lopes reviews the emerging scientific and clinical data on the role of immunotherapy in mutation-positive NSCLC. Tune in to discover how these therapeutics can benefit your patients.

Project Oncology®
Keeping Pace: The Use of Immunotherapy in Mutation-Positive Non-Small Cell Lung Cancer

Project Oncology®

Play Episode Listen Later Jul 15, 2020


Host: Mark A. Socinski, MD Guest: Gilberto de Lima Lopes Junior, MD, MBA, FAMS Advanced non-small cell lung cancer (NSCLC) remains incurable; however, advances in treatment and new insights into the molecular pathogenesis of the disease have led to the development of treatments that significantly extend overall survival. This discussion between Drs. Mark Socinski and Gilberto de Lima Lopes reviews the emerging scientific and clinical data on the role of immunotherapy in mutation-positive NSCLC. Tune in to discover how these therapeutics can benefit your patients.

Project Oncology®
Keeping Pace: The Role of Immunotherapy After Disease Progression

Project Oncology®

Play Episode Listen Later Jul 14, 2020


Host: Mark A. Socinski, MD Guest: Edward B. Garon, MD, MS Advanced non-small cell lung cancer (NSCLC) remains incurable, but overall survival is improving, as shown by new scientific and clinical data that are emerging on the use of checkpoint inhibitors in the frontline setting and after disease progression. This discussion between Drs. Mark Socinski and Edward Garon addresses the role of PD-L1 expression and reviews how the newer checkpoint inhibitors can be applied to clinical practice.

ReachMD CME
Keeping Pace: The Role of Immunotherapy After Disease Progression

ReachMD CME

Play Episode Listen Later Jul 14, 2020


CME credits: 0.25 Valid until: 14-07-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-lung-cancer-role-immunotherapy-after-disease-progression/11724/ Advanced non-small cell lung cancer (NSCLC) remains incurable, but overall survival is improving, as shown by new scientific and clinical data that are emerging on the use of checkpoint inhibitors in the frontline setting and after disease progression. This discussion between Drs. Mark Socinski and Edward Garon addresses the role of PD-L1 expression and reviews how the newer checkpoint inhibitors can be applied to clinical practice.

ReachMD CME
Keeping Pace: The Role of Immunotherapy After Disease Progression

ReachMD CME

Play Episode Listen Later Jul 14, 2020


CME credits: 0.25 Valid until: 14-07-2021 Claim your CME credit at https://reachmd.com/programs/cme/keeping-pace-lung-cancer-role-immunotherapy-after-disease-progression/11724/ Advanced non-small cell lung cancer (NSCLC) remains incurable, but overall survival is improving, as shown by new scientific and clinical data that are emerging on the use of checkpoint inhibitors in the frontline setting and after disease progression. This discussion between Drs. Mark Socinski and Edward Garon addresses the role of PD-L1 expression and reviews how the newer checkpoint inhibitors can be applied to clinical practice.

Project Oncology®
Keeping Pace: The Role of Immunotherapy After Disease Progression

Project Oncology®

Play Episode Listen Later Jul 14, 2020


Host: Mark A. Socinski, MD Guest: Edward B. Garon, MD, MS Advanced non-small cell lung cancer (NSCLC) remains incurable, but overall survival is improving, as shown by new scientific and clinical data that are emerging on the use of checkpoint inhibitors in the frontline setting and after disease progression. This discussion between Drs. Mark Socinski and Edward Garon addresses the role of PD-L1 expression and reviews how the newer checkpoint inhibitors can be applied to clinical practice.

CURE Talks Cancer
56: The Basics of Lung Cancer

CURE Talks Cancer

Play Episode Listen Later Nov 14, 2019 19:47


In this episode of “CURE Talks Cancer,” we spoke with Dr. Mark Socinski to learn more about stage 3 lung cancer and what others should know about the disease.

basics lung cancer mark socinski
ReachMD CME
Practical Considerations on the Use of Immune Checkpoint Inhibitors & Chemotherapy in mNSCLC

ReachMD CME

Play Episode Listen Later Jun 27, 2019


CME credits: 0.25 Valid until: 28-06-2020 Claim your CME credit at https://reachmd.com/programs/cme/practical-considerations-use-immune-checkpoint-inhibitors-and-chemotherapy-mnsclc/10812/ In this panel discussion, Dr. Mark Socinski sits down with Dr. Benjamin Levy and Dr. Jyoti Patel to discuss the ways we can use PD-L1 status to identify when monotherapy or combination therapy is appropriate in patients with newly diagnosed metastatic non-small cell lung cancer (mNSCLC).

GRACEcast Lung Cancer Video
Induction Chemotherapy Followed by Chemo/Radiation for Stage III NSCLC

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 10, 2016 3:46


Dr. Mark Socinski, University of Pittsburgh Medical Center, discusses the benefits of giving two additional cycles of chemotherapy in combination with radiotherapy for stage III NSCLC.

GRACEcast
Induction Chemotherapy Followed by Chemo/Radiation for Stage III NSCLC

GRACEcast

Play Episode Listen Later Feb 10, 2016 3:46


Dr. Mark Socinski, University of Pittsburgh Medical Center, discusses the benefits of giving two additional cycles of chemotherapy in combination with radiotherapy for stage III NSCLC.

GRACEcast ALL Subjects audio and video
Induction Chemotherapy Followed by Chemo/Radiation for Stage III NSCLC

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 10, 2016 3:46


Dr. Mark Socinski, University of Pittsburgh Medical Center, discusses the benefits of giving two additional cycles of chemotherapy in combination with radiotherapy for stage III NSCLC.

GRACEcast Lung Cancer Video
Management of Locally Advanced NSCLC in the Elderly and Frail

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 9, 2016 3:39


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes strategies for treatment of the elderly and frail patient with locally advanced NSCLC.

GRACEcast ALL Subjects audio and video
Management of Locally Advanced NSCLC in the Elderly and Frail

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 9, 2016 3:39


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes strategies for treatment of the elderly and frail patient with locally advanced NSCLC.

GRACEcast
Management of Locally Advanced NSCLC in the Elderly and Frail

GRACEcast

Play Episode Listen Later Feb 9, 2016 3:39


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes strategies for treatment of the elderly and frail patient with locally advanced NSCLC.

GRACEcast ALL Subjects audio and video
Defining Resectability in Stage IIIA Lung Cancer

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 8, 2016 4:04


Dr. Mark Socinski, University of Pittsburgh Medical Center, discusses the factors to consider in defining resectability in stage IIIa lung cancer.

GRACEcast
Defining Resectability in Stage IIIA Lung Cancer

GRACEcast

Play Episode Listen Later Feb 8, 2016 4:04


Dr. Mark Socinski, University of Pittsburgh Medical Center, discusses the factors to consider in defining resectability in stage IIIa lung cancer.

GRACEcast Lung Cancer Video
Defining Resectability in Stage IIIA Lung Cancer

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 8, 2016 4:04


Dr. Mark Socinski, University of Pittsburgh Medical Center, discusses the factors to consider in defining resectability in stage IIIa lung cancer.

GRACEcast
Neoadjuvant Chemotherapy vs. Chemo/Radiation for Stage IIIA NSCLC

GRACEcast

Play Episode Listen Later Feb 7, 2016 3:00


Dr. Mark Socinski, University of Pittsburgh Medical Center, compares the use of chemotherapy to chemo/radiation in the preoperative setting in stage IIIA lung cancer.

GRACEcast ALL Subjects audio and video
Neoadjuvant Chemotherapy vs. Chemo/Radiation for Stage IIIA NSCLC

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 7, 2016 3:00


Dr. Mark Socinski, University of Pittsburgh Medical Center, compares the use of chemotherapy to chemo/radiation in the preoperative setting in stage IIIA lung cancer.

GRACEcast Lung Cancer Video
Neoadjuvant Chemotherapy vs. Chemo/Radiation for Stage IIIA NSCLC

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 7, 2016 3:00


Dr. Mark Socinski, University of Pittsburgh Medical Center, compares the use of chemotherapy to chemo/radiation in the preoperative setting in stage IIIA lung cancer.

GRACEcast
Overall Management for Stage IIIA Disease

GRACEcast

Play Episode Listen Later Feb 6, 2016 2:37


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes the primary treatment options for stage IIIA NSCLC, including chemoradiation and surgery, and discusses trial evidence for each approach.

GRACEcast ALL Subjects audio and video
Overall Management for Stage IIIA Disease

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 6, 2016 2:37


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes the primary treatment options for stage IIIA NSCLC, including chemoradiation and surgery, and discusses trial evidence for each approach.

GRACEcast Lung Cancer Video
Overall Management for Stage IIIA Disease

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 6, 2016 2:37


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes the primary treatment options for stage IIIA NSCLC, including chemoradiation and surgery, and discusses trial evidence for each approach.

GRACEcast
Managing Three Compartments in Stage III Disease (Local, Distant, CNS)

GRACEcast

Play Episode Listen Later Feb 5, 2016 2:34


Dr. Mark Socinski, University of Pittsburgh Medical Center, defines the three compartments in stage III (locally advanced) NSCLC, each of which must be treated.

GRACEcast Lung Cancer Video
Managing Three Compartments in Stage III Disease (Local, Distant, CNS)

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 5, 2016 2:34


Dr. Mark Socinski, University of Pittsburgh Medical Center, defines the three compartments in stage III (locally advanced) NSCLC, each of which must be treated.

GRACEcast ALL Subjects audio and video
Managing Three Compartments in Stage III Disease (Local, Distant, CNS)

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 5, 2016 2:34


Dr. Mark Socinski, University of Pittsburgh Medical Center, defines the three compartments in stage III (locally advanced) NSCLC, each of which must be treated.

GRACEcast Lung Cancer Video
Heterogeneity of Stage III NSCLC/Defining Resectability for Locally Advanced NSCLC

GRACEcast Lung Cancer Video

Play Episode Listen Later Feb 4, 2016 2:07


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes the different types of stage III (locally advanced) NSCLC, and states which of these types tend to be resectable.

GRACEcast ALL Subjects audio and video
Heterogeneity of Stage III NSCLC/Defining Resectability for Locally Advanced NSCLC

GRACEcast ALL Subjects audio and video

Play Episode Listen Later Feb 4, 2016 2:07


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes the different types of stage III (locally advanced) NSCLC, and states which of these types tend to be resectable.

GRACEcast
Heterogeneity of Stage III NSCLC/Defining Resectability for Locally Advanced NSCLC

GRACEcast

Play Episode Listen Later Feb 4, 2016 2:07


Dr. Mark Socinski, University of Pittsburgh Medical Center, describes the different types of stage III (locally advanced) NSCLC, and states which of these types tend to be resectable.

Oncology Data Advisor
Applying Emerging Evidence in Lung Cancer Practice

Oncology Data Advisor

Play Episode Listen Later Aug 11, 2014 53:53


Mark Socinski, MD, Director of the Lung Cancer Section at the University of Pittsburgh Medical Center, leads a case-based discussion on the contemporary management of non-small cell lung cancer.

GRACEcast Lung Cancer Audio
ASCO 2012 Lung Cancer Highlights: Question and Answer Session (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Sep 29, 2012 20:33


Drs. Mark Socinski from Univ. of Pittsburgh and Joel Neal from Stanford Cancer Center answer questions about topics covered in the summary of lung cancer highlights from ASCO 2012.

GRACEcast Lung Cancer Video
ASCO 2012 Lung Cancer Highlights: Question and Answer Session (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Sep 29, 2012 20:34


Drs. Mark Socinski from Univ. of Pittsburgh and Joel Neal from Stanford Cancer Center answer questions about topics covered in the summary of lung cancer highlights from ASCO 2012.

GRACEcast Lung Cancer Video
ASCO 2012 LC Highlights: Dr. Mark Socinski on Key Trials in Small Cell Lung Cancer (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Aug 30, 2012 8:06


Dr. Mark Socinski reviews key results in small cell lung cancer (SCLC) from ASCO 2012, including the SWOG 0802 trial of topotecan +/- VEGF inhibitor aflibercept and a Japanese randomized trial of cisplatin/amrubicin vs. cisplatin/irinotecan.

japanese cancer stage disease trials lung extensive asco vegf sclc small cell lung cancer swog gracecast irinotecan cancergrace socinski mark socinski topotecan edsclc essclc
GRACEcast Lung Cancer Audio
ASCO 2012 LC Highlights: Dr. Mark Socinski on Key Trials in Small Cell Lung Cancer (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Aug 29, 2012 8:06


Dr. Mark Socinski reviews key results in small cell lung cancer (SCLC) from ASCO 2012, including the SWOG 0802 trial of topotecan +/- VEGF inhibitor aflibercept and a Japanese randomized trial of cisplatin/amrubicin vs. cisplatin/irinotecan.

japanese cancer stage disease trials lung extensive asco vegf sclc small cell lung cancer swog gracecast irinotecan cancergrace socinski mark socinski topotecan edsclc essclc
GRACEcast Lung Cancer Video
ASCO 2012 LC Highlights: Dr. Mark Socinski on TAILOR Trial in EGFR wild type Advanced NSCLC (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Aug 27, 2012 7:09


Dr. Mark Socinski from University of Pittsburgh summarizes and critiques the TAILOR trial of Taxotere (docetaxel) vs. Tarceva (erlotinib) in EGFR wild type advanced NSCLC.

GRACEcast Lung Cancer Audio
ASCO 2012 LC Highlights: Dr. Mark Socinski on TAILOR Trial in EGFR wild type Advanced NSCLC (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Aug 26, 2012 7:08


Dr. Mark Socinski from University of Pittsburgh summarizes and critiques the TAILOR trial of Taxotere (docetaxel) vs. Tarceva (erlotinib) in EGFR wild type advanced NSCLC.

GRACEcast Lung Cancer Video
ASCO 2012 LC Highlights: Dr. Mark Socinski on Single Agent vs Doublet Chemo for PS2 (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Aug 19, 2012 6:50


Dr. Mark Socinski from the University of Pittsburgh reviews evidence to support doublet chemo over single agent for marginal performance status (PS2) patients with advanced NSCLC.

GRACEcast Lung Cancer Audio
ASCO 2012 LC Highlights: Dr. Mark Socinski on Single Agent vs Doublet Chemo for PS2 (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Aug 19, 2012 6:50


Dr. Mark Socinski from the University of Pittsburgh reviews evidence to support doublet chemo over single agent for marginal performance status (PS2) patients with advanced NSCLC.

GRACEcast Lung Cancer Video
ASCO 2012 Lung Cancer Highlights: Dr. Mark Socinski on PARAMOUNT Continuation Maintenance Therapy Trial (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Aug 16, 2012 8:37


Dr. Mark Socinski from the University of Pittsburgh reviews the survival benefit and implications from the PARAMOUNT maintenance therapy trial of Alimta (pemetrexed) in advanced NSCLC.

GRACEcast Lung Cancer Audio
ASCO 2012 Lung Cancer Highlights: Dr. Mark Socinski on PARAMOUNT Continuation Maintenance Therapy Trial (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Aug 16, 2012 8:37


Dr. Mark Socinski from the University of Pittsburgh reviews the survival benefit and implications from the PARAMOUNT maintenance therapy trial of Alimta (pemetrexed) in advanced NSCLC.

GRACEcast Lung Cancer Video
Q and A Session on Maintenance Therapy for Advanced NSCLC: When, What, Why, and What’s Left After Post-Maintenance Relapse? (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Apr 18, 2010 15:52


Dr. Mark Socinski, medical oncologist and leader of the Thoracic Oncology Program at Univ. of North Carolina, answers questions about what treatments to recommend after first line therapy for advanced NSCLC and when they should be pursued.

GRACEcast Lung Cancer Audio
Q and A Session on Maintenance Therapy for Advanced NSCLC: When, What, Why, and What’s Left After Post-Maintenance Relapse? (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Apr 18, 2010 15:59


Dr. Mark Socinski, medical oncologist and leader of the Thoracic Oncology Program at Univ. of North Carolina, answers questions about what treatments to recommend after first line therapy for advanced NSCLC and when they should be pursued.

GRACEcast Lung Cancer Audio
Maintenance Therapy for Advanced NSCLC: When, What, Why, and What’s Left After Post-Maintenance Relapse? (audio)

GRACEcast Lung Cancer Audio

Play Episode Listen Later Apr 7, 2010 36:47


Dr. Mark Socinski, medical oncologist and leader of the Thoracic Oncology Program at Univ. of North Carolina, summarizes the evidence and presents a current approach to managing treatment of advanced NSCLC after first line therapy.

GRACEcast Lung Cancer Video
Maintenance Therapy for Advanced NSCLC: When, What, Why, and What’s Left After Post-Maintenance Relapse? (video)

GRACEcast Lung Cancer Video

Play Episode Listen Later Apr 7, 2010 36:40


Dr. Mark Socinski, medical oncologist and leader of the Thoracic Oncology Program at Univ. of North Carolina, summarizes the evidence and presents a current approach to managing treatment of advanced NSCLC after first line therapy.