Podcasts about garon

A trio of celebrity sightings, decreasing in star quality as they go -- and one of them isn't even human! Plus, Garon and Matt watched the American Music Awards so you don't have to.To hear the full episode, head over to nevernotfunny.com and sign up for a Platinum subscription. Plans start at $6/month and include a second full-length episode every week, video of every episode, plus a monthly bonus episode. More perks, like access to our back catalog and game nights on Zoom, are also available. Sign up today!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ray and a Pro Goblin tackle JSA, who is now a full fledged Faction! Lists: Standard Shikami-Hatamoto-ShizokuhE0DanNhASCBLAIBAQAJAIMFAQIAAIceAQIAAICnAQIAAIPkAQEAAIchAQIAAIccAQMAAIcjAQIAAIckAQIAAICQAQsAAgEABgCHHwEGAACD5wEHAACAngECAACAogEBAACHKQEBAAAyAQEA "Well rounded" list that I talked about. My version in Adepticon cut the Shizoku and made upgrades on the "chaff" to fit in a Keisotsu hacker, Uran GML and a Garon, because I was expecting a need to deter the opponent and defend my Capture and Protect Beacon at the front of my DZ, and also to use the Kurayami as a means to both activate consoles and Spotlight entrenched HVTs for UnmaskingKarakuri HarishE0DanNhASCBLAIBAQAJAICaAQUAAICaAQQAAICkAQEAAIccAQMAAICnAQIAAIcnAQEAAIcmAQEAAIckAQIAAIcjAQIAAgEABwCHHwEFAACD5wEHAACAogEBAACHKQEBAACAngEDAACAoQEBAAAyAQEASpecifically good in to TLB, MAF, vCA/Onyx, IA and other factions where you're expecting MSV / GML Alpha Strikes from your opponent. Karakuri are really tough to chew through. Deployable cover engi can be downgraded to fit a Spitfire Hatamoto, but i like the Xvisor Rangebands and Shock Ammo on him more than the PS6We do not talk about the OniwabanhE0DanNhASCBLAIBAQAJAIMFAQIAAIPkAQEAAIcnAQEAAIccAQMAAIb%2FAQIAAICeAQIAAICVAYISAACAkAEBAACHIwECAAIBAAYAgJ0BAwAAg%2BcBBwAAgKIBAQAAhykBAQAAhx4BAgAAgN8BAQA%3Dthis is purpose built for Decap+Firefight tournament packs-Lt is super safe. Shizoku, Sohei, Musashi, Shikami and even the Oni can all do the Veteran/Elite troop cards. We only have Shikami, Teishin and Tokusetsu Engi for specialists so the opp really has to work for kill more specops. There is a lack of FO/spotlight, MSV, and Doctor/Paramedic, but we still cover 15/20 cards. You can hit 19/20 by swapping the Keisotsu for Senku FO (+3 cards) and Musashi for a RuiShi (+1 card).TAG listhE0DanNhASCBLAIBAQAKAIb8AQEAAICTAQQAAICeAQMAAIChAQEAAICiAQEAAIPkAQEAAIckAQIAAIcnAQEAAIcnAQEAAIcjAQIAAgEABgCHHwEGAACD5wEHAACG%2FgECAACAogEBAACHKQEBAAAyAQEA

La Majo, qui gère le foyer jeunes travailleurs à Romorantin lance un dispositif d'hébergement temporaire chez l'habitant pour les jeunes actifs, stagiaires ou en formation. Il n'est pas toujours simple de trouver un logement en zone rurale pour une courte durée. Explications de David Naïl et Paul Dapis de la Majo, au micro de Noëlline Garon.

Après trois ans d'alliance de ces équipes seniors, la composition du Rugby Pôle Sologne sera toute autre la saison prochaine. Romorantin-Lanthenay repart seul, Salbris et Lamotte-Beuvron restent ensembles. Les explications de ce divorce au micro de Noëlline Garon

En octobre 2024, le camping de Vendôme a été touché par une importante crue du Loir. L'établissement a été confronté à d'importants dégâts. Le témoignage des gérants Corinne et Patrick Bernaud, qui ont œuvre pour que le camping rouvre ce mardi 1e avril. Au micro de Noëlline Garon

This week Danielle, Kristine, and Garon are off so in lieu of a new episode enjoy one of our Patreon bonus episodes! This one is pretty infamous already. Hear more bonus episodes plus extended versions of regular episodes at our Patreon: PodcastHowtoSurvive! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 universités se sont regroupés pour travailler sur l'intelligence artificielle et comment l'intégrer au quotidien des étudiants et des personnels. Celle de Tours, fait partie de cette alliance, c'est la seule du Centre-Val-de-Loire. Thierry Brouard, vice-président en charge du numérique et de l'intelligence artificielle répond aux questions de Noëlline Garon.

Garon has a problem with Celebrity Jeopardy. Then, talk of Lady Gaga Oreos leads Justin to wonder if he's been misinterpreting the expiration date on tomato sauce his whole life.To hear the full episode, head over to nevernotfunny.com and sign up for a Platinum subscription. Plans start at $6/month and include a second full-length episode every week, video of every episode, plus a monthly bonus episode. More perks, like access to our back catalog and game nights on Zoom, are also available. Sign up today!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Après le Japan Tours, place au Korean Tours festival, organisé ces 22 et 23 février dans la capitale de l'Indre-et-Loire. Le programmateur Alexandre Sztargott détaille cette première édition au micro de Noëlline Garon.

This week Danielle and Kristine and Garon gather via Zoom in the midst of some sick hosts to learn how to survive being roofied!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Eric Kalver ditches his daughter to fill in for an ailing Garon, and Sam describes the sometimes spooky San Diego comedy scene.To hear the full episode, head over to nevernotfunny.com and sign up for a Platinum subscription. Plans start at $6/month and include a second full-length episode every week, video of every episode, plus a monthly bonus episode. More perks, like access to our back catalog and game nights on Zoom, are also available. Sign up today!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week Danielle and Kristine (and Matt Belknap sitting in for Garon) learn how to survive radicalization of a loved one and Julie Mann joins us to share her poorly timed trip traveling in the Middle East. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Marathon de Cheverny complet, record de participants à celui de Tours : la course à pied attire de plus en plus de gens en Centre-Val-de-Loire. Comment expliquer un tel succès ? Noëlline Garon a posé la question à Pascal Nourrisson directeur de course du marathon de Cheverny et à Dominique Plée, président de la ligue d'athlétisme de Centre-Val-de-Loire.

This week Danielle, Kristine, and Garon record via zoom to talk about the impact the Los Angeles Wild Fires are having and how we're doing. To help those impacted by the fires, please visit CA.Gov or the American Red Cross. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Depuis le mois de mai, la Nouvelle-Calédonie est confronté à des émeutes lié à un projet de réforme constitutionnelle. Si bien que des renforts de secours venus de la métropole ont été envoyés. Le SDIS 41 s'est mobilisé. Noëlline Garon a échangé avec le lieutenant Willy Léger, revenu de mission le 4 novembre.

Dans cet épisode intégral du 8 novembre, en entrevue :  Claude Marchand, Président et chef de la direction chez LCI Éducation Anthony Blais de chez GPHY Isabelle Garon, première vice-présidente Marketing, Communications, Coopération et Bureau du président de chez Desjardins Une production QUB Novembre 2024Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

La récolte de miel n'est pas bonne cette année. La filière enregistre une perte de 40%, avec à peine 12 000 tonnes récoltées. Le Loir-et-Cher ne fait pas exception. Eric Souvent président du syndicat des apiculteurs du département explique la situation au micro de Noëlline Garon.

On the November 2024 episode of the NWYM Podcast, co-hosts Austin and Jacob talk with Pastor Lisa Garon (Sherwood Friends) about church multiplication. Lisa was a guest on the show all the way back on our 2nd episode and she joins us again today to talk about a new podcast she has started called Church Planting Conversations with EFCP where Lisa and her podcast co-host Brian talk about church planting strategies and stories from across the country. Lisa is also the director of communication at Evangelical Friends Church Planting and she spends some time talking about the upcoming Friends Multiplication Conference. Learn more about Northwest Yearly Meeting here: https://nwfriends.org/ You can watch video episodes of this podcast here: https://www.youtube.com/@nwymmedia1007

Les Rockomotives de Vendôme se déroulent du 26 octobre au 2 novembre. Richard Gauvin, le programmateur détaille quelques rendez-vous au micro de Noëlline Garon.

Pour le cinquième tour de la Coupe de France de football ce samedi 12 octobre, Contres reçoit Bourges-Moulon. Trois divisions d'écart entre les deux clubs. Noëlline Garon a interrogé les deux coachs.

Deuxième année pour la campagne d'immunisation contre la bronchiolite. Laura Bouvart, pneumopédiatre à l'hôpital de Blois répond aux questions de Noëlline Garon.

Çdo mëngjes zgjohuni me “Wake Up”, programi i njëkohshëm radio-televiziv i “Top Channel” e “Top Albania Radio”, në thelb ka përcjelljen e informacionit më të nevojshëm për mëngjesin. Në “Wake Up” gjeni leximin e gazetave, analiza të ndryshme, informacione utilitare, këmbimin valuator, parashikimin e motit, biseda me të ftuarit në studio për tema të aktualitetit, nga jeta e përditshme urbane e deri tek arti dhe spektakli si dhe personazhe interesantë. Zgjimi në “Wake Up” është ritmik dhe me buzëqeshje. Gjatë tri orëve të transmetimit, na shoqëron edhe muzika më e mirë, e huaj dhe shqiptare. 

Time to check in with the science desk to determine if sudden heat changes cause earthquakes. If that sounds too highbrow, later Jimmy, Matt, Eliot and Olivia throw balls at Garon's head.To hear the full episode, head over to nevernotfunny.com and sign up for a Platinum subscription. Plans start at $6/month and include a second full-length episode every week, video of every episode, plus a monthly bonus episode. More perks, like access to our back catalog and game nights on Zoom, are also available. Sign up today!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Le championnat de Fédérale 3 de rugby reprend ce 15 septembre. Plusieurs clubs de Centre-Val-de-Loire vont s'affronter cette saison. Quelles sont les ambitions de Blois, Vendôme et Nogent-le-Rotrou ? Réponse dans le zoom de la rédac de Noëlline Garon.

Depuis 2020, la maternité de l'hôpital de Romorantin-Lanthenay a rejoint le label Initiative Hôpital Ami des Bébés (IHAB) mis en place par l'OMS et l'Unicef. Valable 4 ans, l'établissement vient d'obtenir son renouvellement. Les explications de Cécile Bouchan cadre de santé et sage-femme référente, au micro de Noëlline Garon.

Margarita Vasquez-Ponte in conversation with David Eastaugh The original members of the band were Andrew Tully (guitars/vocals), Eric Webster and Angus McPake (bass guitar), Fran Schoppler (vocals), Margarita Vasquez-Ponte (drums), Kevin McMahon (guitars), and Stuart Clarke (guitar). Tully and Vasquez-Ponte were also members of Rote Kapelle, a band that was active from 1985–1988. This initial line-up recorded the first two singles, "Splashing Along" and "The Rain Fell Down" (described by one reviewer as a "pop gem that's not to be missed") on Narodnik Records.

We brought on comic book expert and friend of the show, Garon Williams, to discuss the brilliance that is X-Men 97 season 1.Support the Show.***Patreon: https://www.patreon.com/IMNerdSend listener letters to: imnerdpodcast@gmail.comLinktree: https://linktr.ee/IMNerdPodcastThanks for listening!

Jimmy addresses Garon's recent outburst, and Willie explains how a chance encounter with a legend inspired both his career path and his stage name.To hear the full episode, head over to nevernotfunny.com and sign up for a Platinum subscription. Plans start at $6/month and include a second full episode every week, video of every episode, plus a monthly bonus episode. More perks, like access to our full back catalog, an exclusive T-shirt, a guest photo book and more are also available. Sign up today!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week on The Sample: Matt joins a fantasy music league, and Jimmy needs Garon's help to rewind a recent radio memory.To hear the full episode, head over to nevernotfunny.com and sign up for a Platinum subscription. Plans start at $6/month and include a second full episode every week, video of every episode, plus a monthly bonus episode. More perks, like access to our full back catalog, an exclusive T-shirt, a guest photo book and more are also available. Sign up today!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Garon Taylor is a lineman for the Van Buren District who has a passion for all things outdoors. We talk with Garon about his position at the cooperative, his love of hunting, and how he felt about being named AVECC 2023 Pole Top Rescue Champion. 

In this episode of How This Is Building Me, Drs Camidge and Garon discuss the differences in lung cancer management and drug advancement between the United States and Asia and highlight other topline takeaways from the 2023 WCLC.

World-renowned oncologist D. Ross Camidge, MD, PhD, sits down with guests to discuss the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life's experiences. 

Join Philip, for an eye-opening episode of "Let's Talk About SecurIT" featuring Jon Garon, a Professor of Law at Nova Southeastern University Shepard Broad College of Law, specializing in intellectual property, cybersecurity, and technology law. An expert in entertainment law and privacy, he has published over 60 scholarly works and is a frequent speaker in his fields.  In this insightful episode, Jon dissects the critical balance between data utility and data security, emphasizing the need for better risk models in boardroom discussions. He touches on the stark realities of poor digital hygiene, the increasing cost of cyber insurance, and the potential ramifications for companies that are not proactive about security. Moreover, Jon opens up about the double-edged sword of AI—its potential to solve world problems but also its immediate risks, especially in the hands of bad actors. He warns of the dark times ahead before the good, as AI technologies like GPT-3 and 4 become tools for more sophisticated cyber-attacks. From the consumer's split mindset on privacy to the future of regulatory models, Jon's insights are both timely and thought-provoking. Whether you're an executive, a privacy advocate, or simply tech-curious, this episode is a must-listen. Don't miss it!

We recorded episode 59 in Garon's home studio in Alpine, UT where he records his solo music and where the band, the King will come often records. We talked about treating ourselves like we would treat someone we loved deeply, the power of good, redemptive art, living a prolific life, and much more.   Follow below for more clips and exclusive content Insta- @taylorchurch44 @ofstoneandclaypodcast TikTok- @taylorchurch44 YouTube-youtube.com/taylorchurch

This week Danielle & Kristine & Garon are back together after some vacation time away in this special episode where they discuss the good, bad, and sad of their time apart.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Shiur given by Rabbi Bezalel Rudinsky to the Night Kollel on Hilchos Brachos. Shiur recorded in Yeshivas Ohr Reuven, Monsey, NY.

Shiur given by Rabbi Bezalel Rudinsky to the Night Kollel on Hilchos Brachos. Shiur recorded in Yeshivas Ohr Reuven, Monsey, NY.

Featuring perspectives from Dr Edward B Garon, Dr John V Heymach, Dr Corey J Langer, Dr Ticiana Leal, Dr David R Spigel and Dr Helena Yu, including the following topics: Incorporation of Immunotherapeutic Strategies into the Management of Nonmetastatic Non-Small Cell Lung Cancer (NSCLC) Introduction (0:00) Strategies to cope with platinum shortages (3:11) Selection of appropriate candidates for neoadjuvant chemoimmunotherapy (5:51) Current clinical role of adjuvant anti-PD-1/PD-L1 antibodies (11:03) Patient selection for and practical implementation of consolidation durvalumab (15:40) Faculty presentation: Dr Heymach (18:05) Contemporary Treatment for Localized or Metastatic NSCLC with an EGFR Mutation Adjuvant osimertinib for EGFR mutation-positive localized NSCLC (29:45) Potential implications of FLAURA2 (35:43) Promising investigational strategies for progressive EGFR-mutant disease (38:15) Sequencing of therapies for metastatic NSCLC with EGFR exon 20 insertion mutations (42:01) Faculty presentation: Dr Yu (46:07) Research Advances Shaping the Current and Future Treatment of Metastatic NSCLC with ALK Rearrangements, ROS1 Rearrangements or RET Fusions Selection of first- and later-line treatment for ALK-rearranged NSCLC (54:36) Role of RET-targeted therapy in current clinical practice (56:53) Selection of therapy for ROS1-positive NSCLC, including for patients with CNS involvement (59:30) Faculty presentation: Dr Langer (1:01:25) Targeting MET, HER2 and KRAS Alterations in NSCLC Current clinical role of trastuzumab deruxtecan in NSCLC (1:16:14) Therapeutic sequencing for NSCLC with KRAS G12C mutations (1:20:41) Management of MET exon 14 mutation-positive NSCLC (1:24:33) Faculty presentation: Dr Spigel (1:29:36) Current Management of Metastatic NSCLC without a Targetable Tumor Mutation Anti-PD-1/PD-L1 antibodies for patients for whom biomarker testing is pending (1:38:48) Selection of first-line therapy for newly diagnosed metastatic NSCLC without a targetable tumor mutation (1:41:13) Role of first-line immunotherapy in PD-L1-negative metastatic NSCLC (1:44:17) Implications of antibiotic use and autoimmune toxicity for checkpoint inhibitor efficacy (1:48:15) Faculty presentation: Dr Garon (1:53:41) Future Directions in the Management of Metastatic NSCLC Future directions in NSCLC: Tumor treating fields and datopotamab deruxtecan (2:04:14) Faculty presentation: Dr Leal (2:13:18) CME information and select publications

The Book of James Part 9: The Real Deal - One Day at a Time Bill Corley with guest speakers Original Air Date: 2023.06.11 Special Thanks to our guest speakers: Garon and Susan Harris, Missionaries serving in Mango, Togo Africa If you have brothers or sisters, you understand the nature of the relationship and the ups and downs that come with it. We may not realize it, but Jesus had brothers and sisters... Mark 6:3 tells us, Is not this the carpenter, the son of Mary and brother of James and Joseph and Judas and Simon? And are not his sisters here with us?” And they took offense at him. We don't know much more about His family, but one brother in particular we can learn from is James. James' story is amazing, having gone from little brother and skeptic, to believer in Jesus as the Messiah and leader of the early church and writer of the book that bears his name. We invite you to join us – and James – as we learn more of his story and his teachings on the Christian life and church life. His instructions to believers and the church are amazingly on point for today, they are clear and leave no room for doubt. If you are not one to mince words with others, you'll love James! If you have missed a message or are viewing from home, you can catch weekend services on our Facebook page and YouTube by going to www.crossroads-ridgecrest.org or through the church app. We also have podcasts available by looking up Crossroads Community Church - available on several podcast apps. For questions or information, please contact us at: (760)384-3333 Wednesday – Friday 10am – 4pm, text (760)301-4840 or email ccc@ccc-rc.org

Wednesday night FLX is back and this time Westlake head coach Tony Salazar joins to talk about his first season as the head coach, his coaching tree, and Cade Klubnik. Hutto LB and Air Force signee Brody Bujnoch talks about his career, basketball season, and 7 on 7's. Then Dripping Springs' WR Garon Duncan calls in to discuss his commitment to Yale and former teammate Austin Novosad. Hosts: Zach Lucero, Cameron Parker, and Nolan Hogan Learn more about your ad choices. Visit megaphone.fm/adchoices

The boys are back with the hilarious and talented Taylor Garron! We start the episode by talking about playing it cool and Sebastian talks about how he's mother has no cool. Robbie admits to crying on planes, Maleficent really did him in. Taylor goes on to tell a wild story about a school trip that was wildly inappropriate. The three talk about what it must be like to be rich and Taylor says "A good billionaire is just a millionaire", a genius quote! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Here's a new year treat while Danielle, Kristine and Garon are enjoying the holidays: one of our favorite guests Lauren Ash's own podcast True Crimes & Cocktails featuring her cohost Christy Oxborrow discussing the Glee Curse! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Dwight Owen presents the first update to the ASCO living guideline on stage IV NSCLC without driver alterations. He reviews the new evidence identified by the panel along with the updated recommendation regarding the role of bevacizumab in pemetrexed maintenance therapy. Dr. Owen also discusses exciting trials the panel is looking forward to seeing results of to drive future updates to the living guidelines. Read the update, “Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2022.2“ and view all recommendations at www.asco.org/living-guidelines. Listen to Part 2 for recommendations for patients with stage IV NSCLC with driver alterations. TRANSCRIPT Brittany Harvey: Hello, and welcome to the ASCO Guidelines podcast series, brought to you by the ASCO Podcast Network; a collection of nine programs covering a range of educational and scientific content and offering enriching insight into the world of cancer care. You can find all the shows, including this one, at: asco.org/podcasts. My name is Brittany Harvey, and today I'm interviewing Dr. Dwight Owen, from Ohio State University in Columbus, Ohio, lead author on, 'Therapy for Stage IV Non-Small-Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, version 2022.2.' Thank you for being here, Dr. Owen. Dr. Dwight Owen: Thanks very much, Brittany, for having me. Brittany Harvey: First, I'd like to note the ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest policy is followed for each guideline. The full Conflict of Interest information for this guideline panel is available online with the publication of the guideline in the Journal of Clinical Oncology. Dr. Owen, do you have any relevant disclosures that are directly related to the guideline topic? Dr. Dwight Owen: I have research funding to my institution to conduct clinical trials from several companies, including Merck, Pfizer, Genentech, BMS, and Palobiofarma, but no ownership, no stock, and no employment history. Brittany Harvey: Okay, Thank you for those disclosures. Then let's get into the content of this living guideline update. So, this is the first update to the living clinical practice guideline for systemic therapy for patients with stage IV non-small cell lung cancer without driver alterations. What new evidence was identified by the routine literature searches to prompt an update to the guideline? Dr. Dwight Owen: Yeah, so this is a really exciting time for patients with stage IV non-small cell lung cancer. We are anxiously awaiting the results of some ongoing immunotherapy combination studies. However, for this update, we focused on a specific paper and study that evaluated a treatment that is not our first option anymore, but maybe the first option for a subset of patients. So, before the standard introduction of immunotherapy for patients with stage IV non-small cell lung cancer, we often offered platinum-based doublet chemotherapy, and for years, we studied ways to make that better. So, we might introduce maintenance therapy where we continue a treatment after the first line of induction chemotherapy. We did either continuation maintenance, which is where you continue a treatment that seemed to be effective, or switch maintenance, where you were introduced to new therapy. For many folks with non-squamous non-small cell lung cancer, the standard treatment options included carboplatin or cisplatin with pemetrexed, which is an antifolate chemotherapy, or carboplatin and paclitaxel with or without a VEGF inhibitor, such as bevacizumab. One of the big questions was whether there was a benefit for continuing maintenance therapy with something besides pemetrexed, in this case, bevacizumab, and if bevacizumab was given in combination with pemetrexed, whether continuing that as a maintenance would offer benefit. Now, it's important to point out that the current FDA approval, at least in the United States, is for bevacizumab to be given with carboplatin and paclitaxel. However, several studies looked at the combination with pemetrexed and there were several issues with those studies. So, in one study they used a different agent, so ramucirumab instead of bevacizumab, both VEGF, but slightly different. In one study, the combination that was compared of pemetrexed plus bevacizumab was only compared to bevacizumab maintenance. And so, we really had a sort of hodgepodge of different trials that never answered the question of whether bevacizumab or VEGF therapy, given as maintenance offered any benefit to our patients. What Dr. Garon and co-authors did in a study that we evaluated was conduct a meta-analysis of four of those randomized trials, focusing on the question of comparing pemetrexed maintenance therapy alone versus in combination with bevacizumab. And what they found is that there was no significant difference in overall survival with the addition of bevacizumab compared to pemetrexed by itself, and there were higher rates of toxicity in those patients, including serious and higher-grade toxicities. So, I felt that it was really important to point out that the addition of bevacizumab or other VEGF therapies does not seem to add to a survival benefit when given as maintenance. And even though this is a subset of patients who perhaps could not get immunotherapy as a first-line treatment, maybe because of a pre-existing autoimmune disorder, but for those patients, it doesn't seem that the addition of VEGF as maintenance offers what we were hoping for. Brittany Harvey: Understood, and I appreciate you laying out the landscape of the data in this area. So then, based off this new data and the meta-analysis that you just described, what is the updated recommendation from the expert panel? Dr. Dwight Owen: So, the updated recommendation is a tweak to the established recommendation, which is essentially that for patients who are not candidates for immunotherapy for any reason, that platinum doublet chemotherapy is really the mainstay, and that if maintenance is offered, that it should not include VEGF therapy in combination with pemetrexed as compared to pemetrexed by itself. Brittany Harvey: Understood. And then, what should clinicians know as they implement this updated recommendation? Dr. Dwight Owen: I think, again, this should be a relatively uncommon scenario. Most of our patients are candidates for immune therapy. Many patients are offered platinum pemetrexed by itself. But when thinking about continuing maintenance therapy, we would recommend that most clinicians avoid the addition of therapies that haven't seemed to offer a survival benefit and incur higher rates of toxicity. Brittany Harvey: Great. That's helpful to know. And then you've just mentioned that this doesn't apply to a lot of patients, but what does this change mean for patients with stage IV non-small cell lung cancer without driver alterations? Dr. Dwight Owen: I think, hopefully, for the subset of patients where we're really thinking about here that we can at least avoid additional toxicity if there isn't a trade-off in terms of benefit, in terms of survival. Brittany Harvey: Great. Definitely, that's helpful. And then finally, what ongoing research is the panel keeping an eye on for future living guideline updates? Dr. Dwight Owen: So, there are a lot of exciting trials that are ongoing, and hopefully, we'll be able to read out soon, that would offer us updates for really how to manage these patients in the frontline setting with stage IV non-small cell lung cancer. We have multiple options now. This discussion that we've had today really focuses on the pre-immunotherapy era, but of course, bevacizumab is utilized in a regimen along with carboplatin, paclitaxel, and atezolizumab, compared to monotherapy with checkpoint inhibitors compared to chemoimmunotherapy and dual checkpoint inhibitors. And we don't really have any head-to-head trials yet, or strategies on how to identify which patients need more aggressive combination therapies versus which patients could potentially do without chemotherapy, or with single-agent checkpoint inhibitor by itself. So, while we wait for those studies like the ECOG and Cigna study, we're really looking forward to having those to be able to help decide and tailor our treatment options for our patients. Brittany Harvey: Great. Well, we'll look forward to the ongoing review of the literature by the panel and any future guideline updates to recommendations in the meantime. So, thank you so much for your work on this update and thank you for your time today, Dr. Owen. Dr. Dwight Owen: Thanks for having me. Brittany Harvey: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast series. To read the full guideline, go to: www.asco.org/thoracic-cancer-guidelines. There's also a companion living guideline update on Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations, available there and in the JCO. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in iTunes, or the Google Play store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy, should not be construed as an ASCO endorsement.  

Former LA Kings goaltender Mathieu Garon joins host Jesse Cohen to talk about his time in the Kings franchise, the challenges of being an "All Right" netminder and even his time playing in Siberia! The Ontario Reign Insider Jared Shafran stops by to update us on the play of the LA Kings AHL affiliate. Despite a few missing players, Cal Petersen, Quinton Byfield and Alex Turcotte are all playing well as the Reign are off to a 14-7-0-1 start under new head coach Marco Sturm. 

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In the fourth episode of a four-episode series, Wade and Tain welcome back FOP and newly designated guest host (Eat your heart out, Garon!) retired Henry County State Court Judge Ben Studdard to discuss state administered test law and field sobriety tests. The written outline, with citations, can be found at goodjudgepod.com.

In this week's episode, Danielle & Kristine discuss how to survive a lightning strike. Plus the wonderful Alison Rosen shares a shocking letter from her past. Shockingly embarrassing.Kristine quizzes Danielle and Garon on some common lightning myths and facts.After Kristine shares a ton of information on lightning safety and first aid she digs into the harrowing account of Roy Sullivan.Subscribe to our podcast: https://www.podhowtosurvive.com/Follow us:Website for even more detailed Show Notes! https://www.podhowtosurvive.com/ Instagram: https://www.instagram.com/podhowtosurvive/Twitter: https://twitter.com/podhowtosurviveFacebook: https://www.facebook.com/podhowtosurviveCheck out our merch!https://my-store-c409df-2.creator-spring.com/ Leave us a review, and consider dropping your Twitter or IG handle so we can personally thank you!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Garon Muller rejoins Wade and Tain to discuss apportionment - again! The written outline, with citations, can be found at goodjudgepod.com.

Danielle, Kristine, and Garon learn how to survive being them as they each share the crazy events that happened over the holiday break.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.