Podcasts about Maintenance therapy

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Small Cell Lung Cancer | Faculty Presentation 1: Limited-Stage Small Cell Lung Cancer (SCLC); First-Line and Maintenance Therapy for Extensive-Stage SCLC — Jacob Sands, MD CME information and select publications

Send us Fan MailIn S2E22, we bring on our old Misawa coworker and friend, Josh, to catch up after years of not talking. We get into Josh's retirement life, small-town Arizona living, the opportunity to take over a machine shop, and how machining heads and building engines scratches that old maintenance itch without all the military bullshit from above. From there, we talk about missing the satisfaction of turning wrenches, old crew chief days, small-town life, retirement routines, car projects, Ian's future GTR plans, Josh's '65 and '66 Mustangs, Robby's family truck, painted nails, Whatnot streams, LEGO selling, and the weird balance between hobbies, side hustles, and actual work. Support the show

What happens after first-line treatment for extensive-stage small cell lung cancer (ES-SCLC)? Patient advocate Jill Feldman sits down with Dr. Martin Edelman, Chair of Hematology-Oncology at Fox Chase Cancer Center, to discuss maintenance therapy—also known as continuation therapy—and how it may help keep small cell lung cancer under control after initial treatment. Dr. Edelman explains why small cell lung cancer is so difficult to treat, how immunotherapy has changed the treatment landscape, and why clinical trials remain critical to improving outcomes. He also shares practical advice for patients navigating treatment decisions, managing side effects, and balancing quality of life with ongoing care. You'll learn: What maintenance therapy (continuation therapy) means in small cell lung cancer Why small cell lung cancer often returns after an initial response How immunotherapy is used after first-line treatment Which patients may benefit most from continuation therapy Why clinical trials should be discussed early in treatment Important questions to ask your oncologist The role of supportive and palliative care in improving quality of life What gives experts hope for the future of small cell lung cancer treatment Whether you're newly diagnosed, currently in treatment, or supporting a loved one, this conversation offers practical guidance and hope from one of the leading experts in thoracic oncology. Learn more about lung cancer research, treatment options, and patient resources at lcfamerica.org. Guests Dr. Martin Edelman, MD – Fox Chase Cancer Center Dr. Martin Edelman is Chair of Hematology-Oncology at Fox Chase Cancer Center and a nationally recognized thoracic oncologist. Throughout his career, he has helped advance treatment options for lung cancer patients through clinical research, immunotherapy development, and patient-centered care. Jill Feldman – Lung Cancer Patient Advocate and Host Jill Feldman is a lung cancer survivor, advocate, and nationally recognized voice in the lung cancer community. Through education and advocacy, she helps patients and families navigate diagnosis, treatment decisions, and survivorship. Show Notes: https://lcfamerica.org/wp-content/uploads/2026/06/LCFA-HWA-Maintenance-Therapy-Show-Notes.pdf Transcript: https://lcfamerica.org/wp-content/uploads/2026/06/LCFA-HWA-Maintenance-Therapy-Transcript.pdf YouTube: https://youtu.be/IRf6uF18tTQ  Subscribe to Hope With Answers: Living With Lung Cancer podcast for future episodes on your favorite listening platform.  

Drs. McMahon and Kalunian discuss how the latest lupus nephritis guidelines from the American College of Rheumatology and European Alliance of Associations for Rheumatology are shifting care from short-term, reactive treatment to longer-term, continuous maintenance—often 3 to 5 years or more—to better prevent kidney flares and preserve renal function. They highlight emerging data on biologic-based triple therapy (including belimumab); the importance of biomarkers and repeat biopsies; and the growing push toward personalized, sometimes indefinite, therapy for high‑risk patients.

Featuring perspectives from Dr Virginia F Borges and Dr Ian E Krop, including the following topics: Introduction: Biology of "Triple-Positive" Breast Cancer; Implications for Therapeutic Development (0:00) Cases from the GMO Survey (13:01) First-Line Therapy for Metastatic HER2-Positive Disease (20:01) Maintenance Therapy for HR-Positive, HER2-Positive Disease (30:03) Maintenance Therapy for HR-Negative, HER2-Positive Disease (46:30) Cases from the GMO Survey (50:00) CME information and select publications

Dr Virginia F Borges from the University of Colorado Anschutz Medical Campus in Aurora and Dr Ian E Krop from Yale Cancer Center in New Haven, Connecticut, review clinical research data and best practices guiding the selection of first-line and maintenance therapy for patients with ER-positive, HER2-positive metastatic breast cancer. CME information and select publications here.

Drs. Isaacs and Traina review how HER2CLIMB‑05 and PATINA challenge the old CLEOPATRA‑based approach by showing that adding tucatinib or palbociclib to maintenance therapy can extend progression‑free survival in metastatic HER2+ breast cancer. They stress tailoring maintenance regimens to each patient's hormone receptor status, CNS risk, and tolerance for side effects.

Featuring perspectives from Dr Luis Paz-Ares and Dr Misty Dawn Shields, including the following topics: Introduction: Rational Treatment Goals for Extensive-Stage Small Cell Lung Cancer (ES-SCLC)? (0:00) Current Considerations in the Selection of First-Line and Maintenance Therapy — Dr Borghaei (8:13) Case: A woman in her early 60s newly diagnosed with ES-SCLC who receives first-line atezolizumab/EP and maintenance atezolizumab with delayed addition of lurbinectedin — Dr Borghaei (16:21) Case: A woman in her mid 60s with multiple comorbidities newly diagnosed with ES-SCLC who receives first-line atezolizumab/etoposide and maintenance atezolizumab/lurbinectedin with discontinuation of lurbinectedin — Dr Borghaei (23:46) Clinician Survey Results (32:16) Case: A woman in her early 70s with multiple comorbidities and newly diagnosed ES-SCLC with TP53 and RB1 mutations who receives first-line atezolizumab/etoposide and maintenance atezolizumab/lurbinectedin — Dr Chiang (41:39) Case: A man in his mid 70s with multiple comorbidities and a history of limited-stage SCLC managed with chemoradiation therapy who enrolls in the DeLLphi-312 trial upon disease recurrence — Dr Chiang (47:20) Promising Investigational Strategies — Dr Chiang (49:14) CME information and select publications

Dr Hossein Borghaei from Fox Chase Cancer Center in Philadelphia, Pennsylvania, and Dr Anne Chiang from Yale Cancer Center in New Haven, Connecticut, discuss key clinical trial data in the first-line management of ES-SCLC, real-world case studies and current patterns of care among oncologists.CME information and select publications here.

In this podcast, experts Sara A. Hurvitz, MD, FACP, Michelle Melisko, MD, and Paolo Tarantino, MD, PhD, discuss approaches to maintenance and subsequent lines of therapy for patients with HER2+ advanced breast cancer, including those with CNS metastases.

Featuring perspectives from Dr Luis Paz-Ares and Dr Misty Dawn Shields, including the following topics: Introduction: Tail on the Curve? (0:00) First-Line Chemoimmunotherapy (10:45) Maintenance Lurbinectedin (28:42) Second-Line Treatment, Tarlatamab (45:35) Ongoing Research (53:20) CME information and select publications

Dr Luis Paz-Ares from the Spanish National Oncology Research Center in Madrid and Dr Shields from Indiana University School of Medicine in Indianapolis discuss key datasets surrounding first-line and maintenance therapy for patients with extensive-stage small cell lung cancer and their clinical implications. CME information and select publications here.

Maintenance therapy with ICIs (atezolizumab or durvalumab) is already established in extensive stage small-cell lung cancer, but lurbinectedin enters the chat with a recent FDA approval. Next up - tarlatamab? IMforte (maintenance lurbinectedin + atezolizumab): https://doi.org/10.1016/S0140-6736(25)01011-6 DeLLphi-303 (phase 1b maintenance tarlatamab + ICI): https://doi.org/10.1016/S1470-2045(25)00480-2

Drs. Liu and Scott offer their perspectives on maintenance therapy in patients with small cell lung cancer, discussing the rationale, different approaches, as well as the associated benefits and challenges.

Today we discuss living with metastatic ovarian cancer and how as Nurses, we can support our patients transitioning to oral maintenance therapies. Lisa Peterson, CNC at GenesisCare St Leonards in Sydney, is joined by Dr. Sally Baron Hay, medical oncologist at Royal North Shore Hospital, North Shore Private Hospital, the Mater Hospital, Sydney and Esther White, CNC Cancer Care Coordinator at the Mater in Brisbane. https://www.cnsa.org.au/

In today's episode, we had the pleasure of speaking with Connie Lai, MD, a medical oncology resident at Queen Elizabeth Hospital in Hong Kong, about a retrospective, dual-center study examining post-induction treatment strategies in metastatic colorectal cancer (mCRC).

Drs. Sabari and Socinski discuss maintenance therapy strategies in small cell lung cancer, including immunotherapy, chemotherapy, targeted agents, and radiation.

Mark A. Socinski, MD and Joshua Sabari, MD review new data from ASCO 2025 that have a substantial impact on how oncologists treat patients with extensive-stage small cell lung cancer.

Clinicians-OTs, PTs, and assistants-did not go to therapy school to learn to write notes; unfortunately, clinical documentation is an essential part of every OT or PT visit. Anecdotal evidence and observation suggest that many therapists are documenting how they learned in school, whether that was 1 or 20 years ago. This course explores the current requirements of maintenance therapy. Clinicians will explore the art and science of compliant clinical documentation in the current therapy world. To view accreditation information and access completion requirements to receive a certificate for completing this course, please click here. The content of this Summit podcast is provided only for educational and training purposes for licensed physical therapists and occupational therapists. This content should not be used as medical advice to treat any medical condition in either yourself or others.

In this two-part series host Jonathan Sackier is joined by Bradley Monk, a pioneering figure in gynaecologic oncology. In Part 1, they discuss key updates from the European Society of Gynaecological Oncology (ESGO) Congress, including the updated ESGO-ESTRO-ESP endometrial cancer guidelines and the latest results from the KEYLYNK-001 study in ovarian cancer. With reflections from his three-decade career, Monk provides actionable takeaways for clinicians and researchers alike. Stay tuned for Part 2, where they delve into insights from SGO 2025.  Timestamps:  00:00 - Quickfire questions 04:55 - Career milestones 07:10 - ESGO 2025 standout sessions 09:52 - KEYLYNK-001 trial & takeaways 13:52 - New endometrial cancer staging   

In this week's episode, we'll learn more about how measurable residual disease might help guide decisions about post-transplant gilteritinib maintenance in FLT3-ITD acute myeloid leukemia, or AML; how stemness contributes to chemotherapy resistance in AML; and effects of babesiosis on red blood cells from individuals with sickle cell disease, sickle cell trait, and wild-type hemoglobin. Featured Articles:Measurable residual disease and post-transplantation gilteritinib maintenance for patients with FLT3-ITD-mutated AML GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia Babesiosis and Sickle Red Blood Cells: Loss of Deformability, Heightened Osmotic fragility and Hyper-vesiculation 

This episode explores the treatment of patients with intermediate-risk non-muscle-invasive bladder cancer (IR NMIBC), an important topic in urology today. Expert in the field, Marco Moschini, delves into the topic of risk-adapted treatment, where patients are assigned to a particular risk group based on patient- and tumour-related factors, also taking into account the prior treatment history and the timing of recurrences. Topics discussed include: Current confusion about the clinical heterogeneity within the intermediate-risk patient group The best way to select adequate intravesical therapy for this group The lack of consensus regarding an optimal schedule for adjuvant intravesical chemotherapy *References Scilipoti P, et al. Urol Oncol. 2024;42(12):451.e1-451.e10. PMID: 39060208. European Association of Urology. EAU NMIBC Risk Calculator, https://nmibc.net/ Sylvester RJ, et al. Eur Urol. 2021;79(4):480-488. PMID: 33419683. Tan WS, et al. Eur Urol Oncol. 2022;5(5):505-516. PMID: 35718695. Gontero P, et al. EAU Guidelines on Non-muscle invasive Bladder Cancer (TaT1 and CIS), Limited Update March 2025. European Association of Urology Guidelines Office, Arnhem, The Netherlands, 2025. Full Guideline Friedrich MG et al. Eur Urol. 2007;DOI:10.1016/j.eururo.2007.02.063.

A recent #study from Assiut University Hospital in Egypt, published in #Oncotarget, presents a promising strategy for patients with metastatic #colorectalcancer (mCRC). The #research introduces a gentler yet effective maintenance therapy that may extend survival, enhance quality of life, and offer a more accessible treatment option for mCRC patients worldwide. The Challenge of Treating Metastatic Colorectal Cancer Colorectal cancer is one of the most common causes of cancer-related deaths worldwide. When it spreads to other parts of the body—a stage known as mCRC—it becomes much more difficult to treat. At this stage, clinicians often use strong drug combinations like FOLFOX or CAPOX, which mix chemotherapy drugs to stop cancer growth. FOLFOX combines three drugs given intravenously, while CAPOX includes two of the same drugs, with one taken as a pill. While effective, these treatments can cause serious side effects. For example, one of the main drugs, oxaliplatin, can lead to nerve damage, making it painful or difficult to use the hands and feet. Fatigue, diarrhea, and other issues are also common. Over time, these side effects may force clinicians to stop or adjust the treatment, even if it is working. That is where maintenance therapy comes in. After the cancer is controlled, clinicians often switch to a gentler treatment plan to keep it from returning. The challenge is finding a therapy that continues to work without causing too many side effects, especially in places where access to expensive or intensive treatments is limited. Full blog - https://www.oncotarget.org/2025/05/07/panitumumab-and-low-dose-capecitabine-a-promising-maintenance-therapy-for-metastatic-colorectal-cancer/ Paper DOI - https://doi.org/10.18632/oncotarget.28687 Correspondence to - Doaa A. Gamal - doaaalygamaal@gmail.com Video short - https://www.youtube.com/watch?v=wuPSS0EdK-8 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28687 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, Panitumumab, maintenance, colorectal cancer, Capecitabine About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Anisha B. Dua, MD, MPH and Duvuru Geetha, MD discuss evolving strategies in maintenance therapy for ANCA-associated vasculitis. In keeping with the goal of achieving sustained remission and minimizing relapse, they provide insight into the duration and dosing of maintenance therapy, as well as treatment options and monitoring.

In this episode, host Ken Vinacco talks with Bobby Hand about the role and intricacies of skilled maintenance therapy for individuals with degenerative diseases. Skilled maintenance therapy is the care that physical therapists can provide to individuals who have conditions with no curative treatment. Bobby and Ken delve into how PTs can provide therapy that impacts the individual's quality of life, even when they are not expected to make improvements. Bobby shares examples from his clinical practice, and tips for making it work for your practice.    The Degenerative Diseases Special Interest Group is part of the Academy of  Neurologic Physical Therapy – www.neuroPT.org  For questions about this podcast, please contact neuroddsig@gmail.com   Show notes available here: https://app.box.com/s/h12shsaxu8lpaaxabxk798qd96rpud41

Long-acting muscarinic antagonist and long-acting β2-agonist combination for the treatment of maintenance therapy–naïve patients with chronic obstructive pulmonary disease: a narrative review

In this episode, Improving Survival With HMA Therapy in AML, Dr. Amer Zeidan and Dr. Guillermo Garcia-Manero discuss the latest clinical trial evidence for using hypomethylating agents as maintenance therapy for AML patients as well as which patients will benefit most from these therapies. Visit https://suiteweb.atpointofcare.com/#library/mds-aml/2646.01/page/0 to view the activity and CME/CE information, download the transcript, and complete the posttest and evaluation to earn CME/CE credit.

In this week's episode we'll discuss the outcomes of younger patients with mantle cell lymphoma experiencing late relapse; learn more about mass spectrometry-based assessment of M-protein in peripheral blood during maintenance therapy in multiple myeloma and discuss in vivo CAR T-cell generation in non-human primates using lentiviral vectors.Featured Articles: Outcomes of younger patients with mantle cell lymphoma experiencing late relapse (>24 months): the LATE-POD studyMass spectrometry–based assessment of M protein in peripheral blood during maintenance therapy inmultiple myelomaIn vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand

The process of weaning our patients off biologic disease-modifying antirheumatic drug (b-DMARD) therapy is not unfamiliar in our clinics. However, when attending to our patients, many complications and questions arise. Specific guidance is needed, but where do we turn? Thankfully, our latest guest, Dr. Paul Emery, may have some answers. His latest study, Predicting Flare in Patients With Rheumatoid Arthritis in Biologic Induced Remission, on Tapering, and on Stable Therapy attempted to “identify predictors of flare in patients in stable b-DMARD–induced clinical remission”. Let's dive in together and see what he and his team have found! 

Thomas Powles, MBBS, MRCP, MD - Optimising Outcomes for Our Patients With Advanced Urothelial Carcinoma: Best Practices and Future Directions in Maintenance Therapy

Thomas Powles, MBBS, MRCP, MD - Optimising Outcomes for Our Patients With Advanced Urothelial Carcinoma: Best Practices and Future Directions in Maintenance Therapy

Thomas Powles, MBBS, MRCP, MD - Optimising Outcomes for Our Patients With Advanced Urothelial Carcinoma: Best Practices and Future Directions in Maintenance Therapy

Thomas Powles, MBBS, MRCP, MD - Optimising Outcomes for Our Patients With Advanced Urothelial Carcinoma: Best Practices and Future Directions in Maintenance Therapy

In this episode, we dive into the data on maintenance therapy in multiple myeloma with Dr. Hira Mian and Dr. Manni Mohyuddin. Here are the key studies we discussed:1. Meta-analysis of individual patient-level data from CALGB, IFM, and Italian maintenance RCTs (lenalidomide vs placebo or observation): https://pubmed.ncbi.nlm.nih.gov/28742454/ 2. Myeloma XI RCT (lenalidomide vs observation): https://pubmed.ncbi.nlm.nih.gov/30559051/ 3. Outcomes of lenalidomide maintenance stratified by cytogenetic subgroups (Secondary analysis of Myeloma XI): https://pubmed.ncbi.nlm.nih.gov/36564045/ 4. Canadian real-world data on lenalidomide maintenance: https://pubmed.ncbi.nlm.nih.gov/33054120/ 5. FORTE trial (Carfilzomib-Lenalidomide vs Lenalidomide): https://pubmed.ncbi.nlm.nih.gov/34774221/ 6. ATLAS trial (Carfilzomib-Lenalidomide-Dexamethasone vs Lenalidomide): https://pubmed.ncbi.nlm.nih.gov/36642080/ 7. Differential censoring and potential impact on PFS in ATLAS trial: https://pubmed.ncbi.nlm.nih.gov/37433885/ 8. GEM2014 (Ixazomib-Lenalidomide-Dexamethasone vs Lenalidomide-Dexamethasone): https://ashpublications.org/blood/article-abstract/142/18/1518/497188 9. MASTER trial (MRD-guided treatment de-escalation): https://pubmed.ncbi.nlm.nih.gov/37776872/ 10. Outcomes after MRD-guided treatment discontinuation (Secondary analysis of GEM2014MAIN trial): https://pubmed.ncbi.nlm.nih.gov/37506339/

Who wants to talk about a fun topic?! What if learning about Medicare Maintenance Therapy actually was fun and didn't make you fall asleep? Well, that's what you're going to get on today's episode! We sat down with our favorite Medicare Utilization Reviewer, Dr. Robbie Leonard, PT, DPT, CHC to discuss the hot and sticky points about Medicare skilled therapy. We know a LOT of US-based therapists have questions and we're here to help! In today's show we discuss some common misconceptions about using Medicare for therapy so we can help you pass an audit and stay out of trouble!  Some of the topics covered today include: Medicare's definition of medical necessity and when it does and does not cover services The only 2 standards under which you can treat - restorative and maintenance and what they each mean When do to restorative and when to do maintenance and why you should NOT mix the two The questions you should ask yourself every time you see a patient: Could what I'm doing be provided by a caregiver or technical person that I train? If yes, it should not be billed at all. Unfortunately it doesn't matter whether there is a qualified caregiver available or not. How you get audited: You can be flagged to be audited because your data profile looks different. If you always use or never use KX you can be audited for being an outlier. You should never stop seeing people just because they've reached the threshold. This can be a red flag! What you should NEVER say to a patient about their Medicare dollar usage When it is and is not appropriate to stop providing skilled therapy (hint: it doesn't have to do with where the patient is in their threshold spend!) How to know if you can provide more therapy to a person who's reached their threshold for the year: evaluations will always be covered!  Why you should not be concerned (or turn away) a patient who has used up to their Medicare threshold or beyond Initial threshold What about Medicare and cash? If you're providing a covered service you cannot opt out of Medicare as a therapist. You are legally obligated to file a claim. What does wellness look like then? What does a reasonable time frame actually look like? Jimmo settlement CMS Medicare regulations all US therapists should read: Medicare Benefit Policy Manual Chapter 15, Section 220.2 D NeuroSpark members find the Parkinson Focus Track call recording with Robbie HERE with additional information covered Find Robbie at: robbie@8150advisors.com **Please note, the contents in this episode are for educational purposes and should not be considered legal advice

Maintenance therapy for patients with acute myeloid leukemia, particularly those who are ineligible for transplant, can be critical to treatment outcomes and quality of life for patients. In this episode, CANCER BUZZ speaks with Thomas LeBlanc, MD, hematologic oncologist, associate professor of Medicine, and associate professor in Population Health Sciences at Duke Cancer Institute, about the importance of keeping patients with acute myeloid leukemia in first remission as long as possible through maintenance therapy.   “You have to be aware of the benefits of maintenance therapy…and for patients who are being considered for transplant but who do not end up getting a transplant, it should really be the default option that those patients receive a maintenance therapy.” –Thomas W. LeBlanc, MD   Guest:         Thomas W. LeBlanc, MD Hematologic Oncologist, Associate Professor of Medicine, Associate Professor in Population Health Sciences Duke Cancer Network, Duke Cancer Institute Durham, North Carolina   This is the fourth and final episode of a four-part series developed in connection with the ACCC education program Achieving and Maintaining Better Outcomes for Patients with Acute Myeloid Leukemia. This episode was made possible with support by Bristol Myers-Squibb.   Additional Reading/Sources Improving Care Delivery for Transplant-Ineligible Patients with AML AML Care Coordination in the Community Setting [Video Podcast] Critical Conversation Strategies for Patients with AML [Video Podcast] Strategies to Addressing Disparities in Patients with AML [Video Podcast] Shared Decision-making in Acute Myeloid Leukemia Achieving and Maintaining Better Outcomes for Patients with AML Talking about Acute Myeloid Leukemia (Cancer Support Community) Shared Decision-making: Practical Implementation for the Oncology Team (ACCC)

Allison has some great ideas for Gabe's movie. A listener writes in to ask about no longer "needing" therapy but still wanting to go. Poet Maya Williams joins the show to talk about their new book "Refused A Second Date," intergenerational dating patterns and the process of writing very personal poetry. Finally, should you work with your friends? Or is that a disaster waiting to happen?  Watch clips and the full TLDRI episodes AND listen to the full Wednesday episodes:https://www.patreon.com/justbetweenusThis has been a Gallison ProductionProduced by Melisa D. Monts and Diamond MPrint ProductionsPost-Production by Coco LlorensProduction Assistance by Melanie D. WatsonSupport this podcast at — https://redcircle.com/just-between-us/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Nilay Shah, MD is a clinician-scientist and Associate Professor in the Division of Hematology/Oncology/BMT at Nationwide Children's Hospital. His primary clinical focus is on pediatric solid tumors, including neuroblastomas, tumors of the kidneys, and rare solid tumors of childhood. His research focuses on the molecular drivers of pediatric cancers and how new treatment approaches can be taken to better target those drivers. In this role, he works to identify new uses of currently available anticancer treatments, including drugs originally developed for use against cancers in adults. He serves as Associate Director for Liver Tumor, Kidney Tumor, Germ Cell, and Neuroblastoma Targeted Therapies, and is currently the Sponsor and Study Principal Investigator the CaboMain trial, a Phase 2 study evaluating the efficacy of the oral anticancer agent cabozantinib as a maintenance therapy for ultra-high-risk solid tumors. He also serves as co-director of the Cancer Genetics Program. This program serves to advance the use of genetic and genomic evaluations for the benefits of patients. In this role, he sees patients in the Cancer Predisposition Clinic for evaluation, surveillance, and management of patients with genetic alterations that predispose to cancer development. He also consults on patients for precision oncology, partnering with the Institute for Genomic Medicine to identify therapeutic approaches based on patient tumor and germline genomics. --- What We Do at MIB Agents: PROGRAMS: End-of-Life MISSIONS Gamer Agents Agent Writers Prayer Agents Healing Hearts - Bereaved Parent and Sibling Support Ambassador Agents - Peer Support Warrior Mail Young Adult Survivorship Support Group EDUCATION for physicians, researchers and families: OsteoBites, weekly webinar & podcast with thought leaders and innovators in Osteosarcoma MIB Book: Osteosarcoma: From our Families to Yours RESEARCH: Annual MIB FACTOR Research Conference Funding multiple $100,000 and $50,000 grants annually for OS research MIB Testing & Research Directory The Osteosarcoma Project partner with Broad Institute of MIT and Harvard ... Kids are still dying with 40+ year old treatments. Help us MakeItBetter. https://www.mibagents.org​ Help support MIB Agents, Donate here https://give-usa.keela.co/embed/YAipuSaWxHPJP7RCJ SUBSCRIBE for all the Osteosarcoma Intel

Please visit answersincme.com/FXY860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in psychiatry discusses atypical antipsychotics in the treatment of bipolar I disorder. Upon completion of this activity, participants should be better able to: Identify strategies to improve the diagnostic accuracy of bipolar I disorder (BD-I); Review the clinical profiles of atypical antipsychotics for the treatment of BD-I; and Outline opportunities to individualize treatment for patients with BD-I, based on patient-, disease-, and drug-specific characteristics.

In today's episode, @coach.noush_dpt talks about Maintainence Therapy under CMS guideline and offers some clinical pearls for documentation.   Want to make sure you stay on top of all things geriatrics? Go to https://MMOA.online to check out our Free eBooks, Lectures, & the MMOA Digest!  

We continue our myeloma series, transitioning our discussion from autologous stem cell transplant to maintenance therapy for myeloma.Content:- Why do we use revlimid (lenalidomide) maintenance?- What about in high risk patients?- What is the role of MRD testing?- What about daratumumab in the maintenance setting? This episode has been sponsored by Primum. To sign up for a free account, check out: tfoc.primum.co.Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

Drs. Fernando Fervenza, Marta Casal Moura, and Ulrich Specks discuss the results of their study, "Maintenance of Remission and Risk of Relapse in Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Renal Involvement."

“For those without cancer or other illnesses, we often have a resolution or relief of this fatigue. ‘Oh, I'm just going to go to bed early and get a couple more hours of sleep tonight.' Or ‘I'm going to have a cup of coffee.' But for people with cancer, it's not an easy fix. People with cancer describe fatigue as something much more long-lasting,” ONS member Paula Anastasia, MN, RN, AOCN®, clinical nurse specialist for UCLA Health in Los Angeles, CA, told Jaime Weimer, MSN, RN, AGCNS-BC, AOCNS®, oncology clinical specialist at ONS. Anastasia discussed fatigue in patients with cancer undergoing PARP inhibitor maintenance therapy, management strategies, and nursing considerations. This podcast episode is supported by a sponsorship from AstraZeneca. ONS is solely responsible for the criteria, objectives, content, quality, and scientific integrity of its programs and publications. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Episode Notes NCPD contact hours are not available for this episode. Clinical Update: Ovarian Cancer Focus Group Summary ONS Get Up, Get Moving resources ONS Guidelines™ on Fatigue Oncology Nursing Podcast Episode 227: Biomarker Testing, PARP Inhibitors, and Oral Adherence During Ovarian Cancer Maintenance Therapy ONS Voice articles: Symptom Assessments: Use a Team-Based Approach to Inform Care and Optimize Outcomes Master the Essentials of Effective Communication What the Evidence Says About Music Therapy for Cancer-Related Fatigue Acupuncture for Cancer-Related Fatigue Biomarkers Are Advancing Understanding of Cancer-Related Fatigue Clinical Journal of Oncology Nursing articles: The Impact of a Nurse-Led Exercise Activity for Cancer-Related Fatigue in Patients With Leukemia Exercise Intervention: A Pilot Study to Assess the Feasibility and Impact on Cancer-Related Fatigue and Quality of Life Among Patients With High-Grade Glioma Oncology Nursing Forum article: The Effectiveness of Yoga on Cancer-Related Fatigue: A Systemic Review and Meta-Analysis National Comprehensive Cancer Network Guidelines > Supportive Care > Cancer-Related Fatigue ASCO Answers: Cancer-Related Fatigue To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From Today's Episode “Fatigue is not necessarily life threatening, so I think unfortunately, it's underplayed at how disruptive it can be in somebody's quality of life and day-to-day life.” Timestamp (TS) 03:10 “For those without cancer or other illnesses, we often have a resolution or relief of this fatigue. ‘Oh, I'm just going to go to bed early and get a couple more hours of sleep tonight.' Or ‘I'm going to have a cup of coffee.' But for people with cancer, it's not an easy fix. . . . People with cancer describe fatigue as something much more long lasting.” TS 04:02 “I think it's really important when we educate our patients to let them know that this is a common side effect. Research tells us, and also patient experience, that fatigue does plateau after about four to eight weeks. It's not zero, but it gets much more manageable for our patients. So, I think priming our patients with what to expect can be very helpful.” TS 07:48 “I want patients to have some sort of physical activity. It doesn't have to be hours or marathons. Just a 10-minute walk in the morning and then maybe a 10-minute walk in the afternoon. Things like that. We try to, if possible, refer patients to a physical therapy-type setting initially, and that will help give them tools on how to be active and safe activities, and also gets them motivated. So, that's really helpful for patients.” TS 09:41 “I think it's important to assess the cause of the fatigue. Ruling out anemia, hypothyroidism, vitamin deficiencies, things like that. So, that is ruled out and we know what we're doing to our poor patient with the interventions; they've had surgery, they've had chemotherapy, now we're going to put them on a PARP inhibitor, all of these lifestyle changes.” TS 12:20 “I think since COVID-19, there's a lot more awareness of how much people have anxiety and depression. I think we're more in tune with that and how stressful life is, and that's not even having cancer and all of the challenges with that. So, I think that plays into it. Depression and anxiety can contribute to fatigue.” TS 16:53  “One of the biggest misconceptions about fatigue is that there's nothing that you can do about it. Just accept it. And I totally disagree with that. It's an undervalued side effect. It's not necessarily life threatening, but it's definitely something that can interfere with patients' day-to-day quality of life. So, we really need to address it. We need to assess, communicate, and plan for it.” TS 28:39

Maintenance therapy over the past several years has commonly included the use of Revlimid (lenalidomide) over a long period of time. Is more better? Does more maintenance therapy or certain combinations help extend remissions or help patients deepen their responses?  Ashraf Badros, MD, of the University of Maryland will join the HealthTree Podcast for Multiple Myeloma to talk with us about the rationale behind the AURIGA clinical trial using daratumumab and lenalidomide following stem cell transplant for patients who are still MRD positive.  Myeloma experts are working to identify more personalized approaches for each type of myeloma patient. We know that patients who are still MRD positive following high dose therapy are more likely to have shorter remissions and the use of a different maintenance therapy may help patients who aren't getting their deepest responses do better over time.  Thanks to our episode sponsor, Takeda Oncology

Maintenance therapy over the past several years has commonly included the use of Revlimid (lenalidomide) over a long period of time. Is more better? Does more maintenance therapy or certain combinations help extend remissions or help patients deepen their responses?  Ashraf Badros, MD, of the University of Maryland will join the HealthTree Podcast for Multiple Myeloma to talk with us about the rationale behind the AURIGA clinical trial using daratumumab and lenalidomide following stem cell transplant for patients who are still MRD positive.  Myeloma experts are working to identify more personalized approaches for each type of myeloma patient. We know that patients who are still MRD positive following high dose therapy are more likely to have shorter remissions and the use of a different maintenance therapy may help patients who aren't getting their deepest responses do better over time.  Thanks to our episode sponsor, Takeda Oncology

“We found that nurses still needed clarity of terminology and the rationale for germline, somatic, and homologous recombination deficiency testing,” ONS member Paula Anastasia, MN, RN, AOCN®, clinical nurse specialist for UCLA Health in Los Angeles, CA, told Jaime Weimer, MSN, RN, AGCNS-BC, AOCNS®, oncology clinical specialist at ONS. Anastasia discussed the findings of a July 2022 ONS focus group that she facilitated on PARP inhibitor therapy, biomarker testing and terminology, and oral medication adherence for patients with ovarian cancer. This podcast episode is supported by a sponsorship from AstraZeneca. ONS is solely responsible for the criteria, objectives, content, quality, and scientific integrity of its programs and publications. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Episode Notes NCPD contact hours are not available for this episode. Clinical Update: PARP Inhibitors Survey: 2022 Member Feedback on Ovarian Cancer Treatment Focus Group Outcomes ONS Biomarker Database ONS Genomics and Precision Oncology Learning Library ONS Guidelines™ to Support Patient Adherence to Oral Anticancer Medications Oncology Nursing Podcast episodes: Episode 215: Navigate Updates in Oral Adherence to Cancer Therapies ONS Voice articles: Oncology Nurses' Role in Translating Biomarker Testing Results Maintain Oral Adherence With ONS Guidelines™ Help Patients Understand Biomarker Test Results and Clinical Trials Options Genetic Counselors Help Patients and Providers Understand Biomarker Testing Goals and Results Nursing Considerations for Ovarian Cancer Survivorship Care An Oncology Nurse's Primer on Genomics and Biomarker Terminology Ovarian Cancer: Prevention, Screening, Treatment, and Survivorship Recommendations Clinical Journal of Oncology Nursing article: Shifting to a Biomarker Paradigm Across Cancer Care ONS video: Cancer Treatment Therapies Overview Oral Chemo Patient Education Sheets National Society of Genetic Counselors To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From Today's Episode “We found in this focus group that nurses still needed clarity of terminology and the rationale for germline and somatic/homologous recombination deficiency (HRD) testing. They all shared that those who worked in the infusion center in general medical oncology offices as opposed to the specific gynecologic clinics, that they weren't as familiar with somatic and HRD terminology as you would suspect.” Timestamp (TS) 06:31 “As cancer care is evolving and patients are living longer and better, I think it's we nurses who are actually the ones that are doing these behind the scenes. The most common barriers that were consistently discussed across the board were cost and insurance approvals. . . . Other issues were access to the results. Results are not always being uploaded into the patient's medical record.” TS 09:51 “The nurses discussed wanting more knowledge of the mechanism of action with PARP inhibitors and how that alteration benefits patients with germline or somatic mutations. And most nurses did agree that their patients were offered germline testing at the time of diagnosis, but they were unclear as to when somatic or HRD testing was being done. . . . It was very inconsistent, so not all nurses knew where to find these results or to even know if it was done.” TS 16:54 “Education was key, and the nurses all agreed that it was important to identify who the appropriate patient would be that would most likely receive a clinical benefit, and who also would be following through or maintaining oral adherence. It was recommended to reinforce the side effects with the patients. . . . It was determined that patients should be informed that the goal of treatment of maintenance therapy was to prevent or decrease risk of recurrence.” TS 18:17 “It was recommended to assess patient adherence by asking open-ended questions. . . . The nurses agreed that the most common question to ask a patient would be: ‘How many doses did you miss this week? Or this month?' Recognizing that people miss doses, and it's not necessarily intentional, but it does happen, so we are validating and giving them permission to be honest with us.” TS 21:26 “I think having tools or resources—quick handouts—that they can give their patients that's like an easy guide, and they can review it with the patient, but the patient if they have questions can follow up. I think it's important to find out the patient's needs and how they learn best, on a video or paper, that sort of thing. . . . But the nurses also wanted quick-references guides, just an overview of what the indication is, what needs to be done prior to ordering this, and the mechanism of action.” TS 30:32

Marinos Dalakas discusses his most recent publication with Neurology on IVIg efficacy in GAD65 positive SPS patients.  Show references: https://nn.neurology.org/content/9/5/e200011 This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.

Stacey Clardy interviews Marinos Dalakas to discuss his most recent publication with Neurology on IVIg efficacy in GAD65 positive SPS patients. Read the full article here in Neurology.   This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.

Dr Monk discusses pertinent efficacy and safety data from the ATHENA-MONO trial, which evaluated first-line maintenance treatment with rucaparib in patients with stage III-IV high-grade ovarian cancer.