Podcasts about villous

It's the beginning of April, which for me means that I get to chat with my friend Ellen Bayens of theceliacscene.com about interesting articles and studies she has brought to our attention over the past month. I had to record with Ellen prior to end of the March as I was preparing for knee surgery. Ellen kept posting and you can keep up with her work by subscribing to her monthly newsletter through her website. Ellen and I both had copies of the recent booklet produced by Celiac Canada with the preliminary results from their recent survey. There is so much information in these numbers and the analysts have only scratched the surface. You can read these initial results or download the booklet at celiac.ca. Both Ellen and I felt my recent conversation with Linda Sills regarding retirement and long-term care for her celiac mother was concerning and something we should all be concerned about for our families and ourselves. Ellen mentioned a previous a podcast I recorded with Mike Rose about choosing safe retirement living – you can listen at - https://acanadianceliacpodcast.libsyn.com/ep-168-retirement-living-gluten-free. As well Ellen wrote an article about Mike which you can read here - https://theceliacscene.com/celiac-crusader-tackles-challenges-residential-living/ Ellen told us about a new online mentoring program for kids and teens that is being started – you can find out more here - Introducing Celiac Chat - An Online Mentorship Program for Kid & Teens  and hopefully I will speak with Avery for a podcast in the near future. Villous atrophy is a term that many of us know from our diagnosis, but Ellen was able to show me an article that listed other conditions that may cause villous atrophy – and here I was thinking it was unique to Celiac Disease. Other Conditions that May Cause Villous Atrophy  On a social media note Ellen told us of a situation at a local restaurant in Victoria that recently decided to remove a popular gluten free item from their menu. This was of course unfortunate, but the negative comments on social media that ensued were somewhat over-the-top. Ellen and I comment on the issues. I mention that I recently attended a virtual class from Cinde, the everydayglutenfreegourmet.ca. I highly recommend these classes as we can all learn to make more gluten free options. Sue's Websites and Social Media – Podcast https://acanadianceliacpodcast.libsyn.com Podcast Blog – https://www.acanadianceliacblog.com Email – acdnceliacpodcast@gmail.com Celiac Kid Stuff – https://www.celiackidstuff.com Baking Website – https://www.suesglutenfreebaking.com Instagram - @suesgfbaking YouTube - https://www.youtube.com/playlist?list=PLUVGfpD4eJwwSc_YjkGagza06yYe3ApzL Email – sue@suesglutenfreebaking.com Other Podcast – Gluten Free Weigh In – https://glutenfreeweighin.libsyn.com

It's the beginning of April, which for me means that I get to chat with my friend Ellen Bayens of theceliacscene.com about interesting articles and studies she has brought to our attention over the past month. I had to record with Ellen prior to end of the March as I was preparing for knee surgery. Ellen kept posting and you can keep up with her work by subscribing to her monthly newsletter through her website. Ellen and I both had copies of the recent booklet produced by Celiac Canada with the preliminary results from their recent survey. There is so much information in these numbers and the analysts have only scratched the surface. You can read these initial results or download the booklet at celiac.ca. Both Ellen and I felt my recent conversation with Linda Sills regarding retirement and long-term care for her celiac mother was concerning and something we should all be concerned about for our families and ourselves. Ellen mentioned a previous a podcast I recorded with Mike Rose about choosing safe retirement living – you can listen at - https://acanadianceliacpodcast.libsyn.com/ep-168-retirement-living-gluten-free. As well Ellen wrote an article about Mike which you can read here - https://theceliacscene.com/celiac-crusader-tackles-challenges-residential-living/ Ellen told us about a new online mentoring program for kids and teens that is being started – you can find out more here - Introducing Celiac Chat - An Online Mentorship Program for Kid & Teens  and hopefully I will speak with Avery for a podcast in the near future. Villous atrophy is a term that many of us know from our diagnosis, but Ellen was able to show me an article that listed other conditions that may cause villous atrophy – and here I was thinking it was unique to Celiac Disease. Other Conditions that May Cause Villous Atrophy  On a social media note Ellen told us of a situation at a local restaurant in Victoria that recently decided to remove a popular gluten free item from their menu. This was of course unfortunate, but the negative comments on social media that ensued were somewhat over-the-top. Ellen and I comment on the issues. I mention that I recently attended a virtual class from Cinde, the everydayglutenfreegourmet.ca. I highly recommend these classes as we can all learn to make more gluten free options. Sue's Websites and Social Media – Podcast https://acanadianceliacpodcast.libsyn.com Podcast Blog – https://www.acanadianceliacblog.com Email – acdnceliacpodcast@gmail.com Celiac Kid Stuff – https://www.celiackidstuff.com Baking Website – https://www.suesglutenfreebaking.com Instagram - @suesgfbaking YouTube - https://www.youtube.com/playlist?list=PLUVGfpD4eJwwSc_YjkGagza06yYe3ApzL Email – sue@suesglutenfreebaking.com Other Podcast – Gluten Free Weigh In – https://glutenfreeweighin.libsyn.com

In this episode, we review the high-yield topic of Chorionic Villous Sampling / Amniocentesis from the Obstetrics section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

This is the first in a new series of BMJ Open Gastroenterology interviews, in which we will be covering high-profile publications in conjunction with the lead authors of the papers. In this quarter's podcast, we will be discussing a review article entitled ‘Enteropathies with villous atrophy but negative coeliac serology in adults: current issues' published online in November 2021 (https://bmjopengastro.bmj.com/content/8/1/e000630). Dr James Ashton (Social Media Editor of BMJOG) interviews Dr. Annalisa Schiepatti, researcher at the University of Pavia, Italy, and a junior consultant at the Gastroenterology Unit of Maugeri Insitute in Pavia. Listen to our regular podcasts and subscribe in Apple Podcasts, Google Podcasts, Stitcher and Spotify.

Iago Rodríguez-Lago talks to Neil O'Morain (Galway, Ireland) about his research about the effect of angiotensin receptor blockers in patients on a gluten-free diet.

According to the University of Chicago Celiac Disease Center, 10% of MS patients also suffer from celiac disease. Studies conducted in Italy and Spain uncovered a significant increased prevalence of celiac disease in first-degree relatives of MS patients, 18% and 32% respectively. Additional research has identified situations in which celiac disease mimicked other neurological disorders such as MS and ALS.  With evidence like that, it is definitely worth it to further explore the relationship between MS and celiac disease. Today, the Gluten Free RN investigates whether MS and celiac disease are similar, related, or perhaps the same thing, as she shares case studies from the literature and her own experience. Nadine discusses the story of Dr. Terry Wahls, explaining how she was able to resolve her symptoms of MS with a variation of a Paleo diet. She outlines the analogous symptoms of MS and celiac cerebellar ataxia, the neurological damage caused by gluten, and how malabsorption of nutrients caused by intestinal damage can extend to medication. Listen and learn how Nadine and others have resolved symptoms of MS and other neurological disorders on a gluten-free diet! What’s Discussed:  Nadine’s MS scare Bouts with falling, dragging feet Numbness, tingling (neuropathy) Symptoms disappeared after adopting gluten-free diet Takes two to three years to resolve neurological symptoms Dr. Terry Wahls’ story Diagnosed with MS, confined to wheelchair Continued to research condition Adopted version of Paleo diet Now walks without cane, rides bike again Conducts seminars to share how healed mitochondria The commonalities between celiac disease and MS Both autoimmune issues Studies necessary to determine if conditions are similar, related, or the same How celiac disease affects the body Triggered by ingestion of gluten Causes villous atrophy, cryptic hyperplasia in small intestines, damage to immune system Primarily neurological disorder The symptoms of celiac cerebellar ataxia Poor balance Hard to distinguish where body is in space Trip, stumble or fall Related to vision The multi-organ manifestations of celiac disease in the central nervous system White matter lesions Inflammatory cerebral spinal fluid syndrome Sinus venous thrombosis Epilepsy, seizure disorders Cerebellar pontine atrophy Encephalopathy Myelopathy Dementia Gluten ataxia Migraines, headaches Depression, anxiety Cerebellar ataxia Nadine’s patient who wasn’t responding to MS medication Nadine recommended celiac testing Panel negative, but gene carrier Already adopted gluten-free diet Fewer medications necessary Hope to decrease, discontinue meds Malabsorption issues extend to medications, could stem from undiagnosed celiac disease The 2014 study in Vienna regarding celiac disease and MS Concluded that celiac disease may mimic MS Celiac disease may be present despite absence of anti-gliadin antibodies If patient history indicates gastrointestinal issues, celiac disease should be considered even if CSF and MRI findings suggest MS The new evidence around seronegativity in celiac disease Most labs only test for tissue transglutaminase 2 Transglutaminase 6 is specific for neurological damage caused by gluten The 2014 Italian study of the genetic overlap between celiac disease and MS Sites significant increased prevalence of celiac disease in MS first-degree relatives (18%) Recommends celiac testing in MS patients who aren’t responding to MS treatment or present with ataxia The association between MS and celiac disease as reported by the University of Chicago Celiac Disease Center Approximately 10% of those who have MS also have celiac disease The genes that indicate a predisposition to celiac disease HLA-DQ2 HLA-DQ8 The 2013 Iranian case study of a celiac patient diagnosed with MS 37-year-old woman with history of chronic abdominal pain Diagnosed with celiac disease, adopted gluten-free diet Became ataxic, met with neurologist MRI indicated multiple sclerosis Nadine argues that patient likely re-exposed to gluten How gluten acts as a neurotoxin Pastor exposed to gluten in cookies had acute neurological event Shaking, tremors (similar to stroke) The 2007 Oxford case study of celiac disease mimicking ALS 44-year-old man with progressive right-sided spastic hemiparesis (muscle wasting) Remote family history of celiac disease Strict gluten-free diet resolved most symptoms Why patients with neurological symptoms should be tested for celiac disease The anti-gliadin antibody is excellent biomarker for gluten sensitivity Why it is acceptable to adopt a gluten-free diet if your antibody test is negative for celiac disease The Paleo diet Nadine suggests for celiac and gluten-sensitive patients Gluten-, dairy-free Whole food Low carb, super-good high fat The increased prevalence of celiac disease in MS patients revealed in a 2011 study Increased prevalence found in eight of 72 MS patients (11.1%) Also in first-degree relatives (13/126 or 32%) Advises increased efforts aimed at early detection and dietary treatment The fundamentals of MS Chronic disease of unknown etiology T-cell mediated antibody response Leads to demyelination of central nervous system Associated with autoimmunity (body attacking itself) Damage to enteric nervous system can lead to constipation How to conduct your own research around celiac disease and neurological disorders Celiac researcher Dr. Marios Hadjivassiliou How long it takes to heal on a gluten-free diet Villous atrophy heals in six months to one year Neurological damage takes two to four years The nutrients a celiac patient is missing that contribute to neurological issues B vitamins Trace amounts of copper Magnesium Zinc The autoimmune symptoms Nadine resolved/reversed with a gluten-free diet MS symptoms Graves’ disease Positive ANA panel Why it’s important for celiac patients to work with educated practitioners who understand functional medicine Resources: Dr. Terry Wahls’ TED Talk The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principle by Terry Wahls MD “Celiac Disease with Cerebral and Peripheral Nerve Involvement Mimicking Multiple Sclerosis” in the Journal of Medicine and Life “Celiac Disease in Multiple Sclerosis: A Controversial Issue” in the International Journal of Neurology and Neurotherapy University of Chicago Celiac Disease Center MS Info “Multiple Sclerosis or Neurological Manifestations of Celiac Disease” in Advanced Biomedical Research “A Case of Celiac Disease Mimicking Amyotrophic Lateral Sclerosis” in Nature Clinical Practice Neurology “Prevalence of Celiac Disease in Multiple Sclerosis” in BMC Neurology “A Case of Concurrent Multiple Sclerosis and Celiac Disease” in Govaresh “Neurological Disorders in Adult Celiac Disease” in the Canadian Journal of Gastroenterology “A Case of Multiple Sclerosis and Celiac Disease” in Case Reports in Neurological Medicine  Connect with Nadine:  Instagram Facebook Contact via Email ‘Your Skin on Gluten’ on YouTube Melodies of the Danube Gluten-Free Cruise with Nadine Books by Nadine: Dough Nation: A Nurse's Memoir of Celiac Disease from Missed Diagnosis to Food and Health Activism

This episode of ‘Gluten Free RN’ covers the basics of celiac disease and gluten intolerance – what those terms mean and what they might mean for you. Nadine explains which genes suggest a predisposition to gluten intolerance and what circumstances lead to a diagnosis of celiac disease proper.  Nadine talks you through what happens in your digestive tract that leads to gluten proteins attacking your organs and preventing your body from absorbing the nutrients it needs. She also outlines the foods and products you need to avoid to achieve ‘gluten-zero,’ as well as the foods you can enjoy as part of a gluten-free diet.  Listen in and learn where gluten is hiding and how to modify your diet to reverse the adverse effects of gluten! What’s Discussed:  The definition of celiac disease and its chronic nature 30-50% of the population carries the genes How a trigger event (i.e.: a cold, pregnancy, stress, an injury) initiates the autoimmune disorder Options for getting tested for the genetic predisposition The closed system of the digestive tractand how food is processed While some food is used for energy, much just passes through Villous atrophy and the four stages of tissue damage Marsh 1: microvilli destroyed; body cannot break down sugar and milk Marsh 2/3: villi themselves fold over or atrophy; tight junctures between villi (that keep things your body can’t utilize in the GI tract and out of your bloodstream) open up Marsh 4: villi gone and only red, inflamed tissue remains; ‘leaky gut’ The effects of increased permeability of the intestinal wall Damaged immune system Rather than passing through the GI tract, gluten proteins get into bloodstream and wreak havoc on organs Body can’t absorb nutrients out of food The importance of healthy intestinal tissue 70-90% of the immune system is in your intestines The soldier analogy Healthy villi are like rested soldiers with loaded weapons on a clear day who can easily take out antigens that don’t belong Damaged villi are like soldiers on a bender with inadequate weaponry, operating in smoke and fire – they either don’t work at all or fire randomly at antigens The long road to recovering from villous atrophy It takes 6 months to a year to reverse the damage Grains to avoid that contain gluten Wheat Barley Rye Oats (due to cross-contamination) Places where gluten may be hiding Gluten-free foods Fresh fruits and vegetables Plain meats and fish (not breaded or beer battered) Beans/legumes Tree nuts Rice, corn and potatoes Quinoa and teff Dairy What a gluten-free rating means The Gluten Intolerance Group (GIG) certifies products that contain less than ten parts per million Resources Mentioned:  Gluten: Zero Global by Rodney Ford  Enterolab Website  Glutenpro Celiac Test  Country Life Vitamins  Kite Hill Foods Connect with Nadine:  Instagram Facebook Contact via Email Books by Nadine: Dough Nation: A Nurse's Memoir of Celiac Disease from Missed Diagnosis to Food and Health Activism  

You need to know what normal looks like before you can recognise what is abnormal. Susan Anderson takes you on a tour of the mucosa of the stomach and duodenum in this video podcast. You'll be able to see the different structures in the mucosa, glands and those villi which become atrophic in coeliac disease. A much more interesting way to learn about histology than looking in a textbook and quicker than sitting in a lecture. Dr Susan Anderson is Associate Professor of Surgery at the University of Nottingham, UK

Dr. Gail E. Besner discusses her manuscript Heparin-binding EGF-like Growth Factor Increases Intestinal Microvascular Blood Flow in Necrotizing Enterocolitis. To view the print version of this abstract go to http://tinyurl.com/l4w7ew

Aim: Human chorionic gonadotropin (hCG) is produced by fetal trophoblast cells and secreted into maternal circulation mainly in the first trimester of pregnancy. Another glycoprotein, glycodelin A, is one of the main products of the maternal decidua during this period. The purpose of this study was to investigate the effect of glycodelin A on hCG release by isolated cytotrophoblast cells in vitro. Methods: Cytotrophoblast cells were prepared from human first trimester placenta and incubated with varying concentrations of glycodelin A. Supernatants were assayed for hCG protein concentrations, and quantification of beta hCG mRNA was carried out by RT-PCR. Expression of hCG was analysed in stimulated trophoblast cells and in unstimulated controls by immunocytochemistry. Results: Glycodelin A induces a dose-dependent increase of hCG production. An increase of hCG expression was measured at 100 and 200 mu g/mL glycodelin-A treatment in trophoblast cell culture by TaqMan assay on mRNA level. We found a moderate staining of hCG in control trophoblast cells, whereas a strong hCG staining was seen in glycodelin A-treated trophoblast cells. Conclusions: HCG is a marker for the differentiation process of trophoblast cells. Our results suggest that glycodelin A secreted by the decidualized endometrium is involved in the regulation of hormones produced by the trophoblast.