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We're filling summer reading lists and making sure that you have plenty of beach reads ready for whatever your plans are! It's hard to believe it's July, but we've got another quarterly upcoming romance episode here to ease the pain of half the year already passed! Here's a huge list of books arriving in July, August & September 2026—historical, paranormal, speculative, contemporary, a YA or two and a romantic suspense or two, we've got something for everyone. As a reminder, we haven't read most of these, but we have big plans!If you want more recommendations and more people with whom you can discuss 2026 romance novels, maybe you want to join our Patreon? You get an extra monthly episode from us and access to the incredible readers and brilliant people on the Fated Mates Discord! Support us and learn more at fatedmates.net/patreon.Our next read along is an old school contemporary, Perfect by Judith McNaught. Sarah says it has the greatest all-is-lost moment in romance history. Read it to find out if she's right. Get it at Amazon, Barnes & Noble, Kobo, Apple Books or wherever you get your books.AUTHORS: Do you have a book coming out in 2026 that you'd like to make sure we know about? Or, are you a debut romance author who'd like to make sure we know about your debut? Fill out the forms here:2026/2027 Upcoming Romance Novels2026 Debut Romance NovelsJune Releases (Better Late Than Never)Love is a Contact Sport by Frederick SmithA Deal at Dawn by Vanessa RileyJuly ReleasesSeduced by the Werewolf Highwaymen by Eva LeighFIRE on Fire by Lukas GainesPrincess Bride with Benefits by Bella MasonAs Long as it Takes by Jill FrancisDie For Me by Shirlene ObuobiKiss, Marry, Kill by Cara TanamachiThe Paddock Club by Madge MarilAffairs of State by Calvin JamesFormula Zero by Meredith LanzenA Date with Death by Kelly CreaghDearest Beast by Felicia GrossmanFalling For You by Natasha MadisonThe Romance Revival by Christina LaurenEclipse of the Crown by AK CaggianoTheir Summer Rescue by Sera Taíno Maggie and Arthur's Magic Moment by Leslie ReneFoxx by Paisley HopeRavenous by Kresley ColeAn Education in Longing by Charlotte SteinOne Shattered Crown by Rebecca ZanettiAugust ReleasesI Punched an Alien and Now We're in Couples Therapy by Kimberly LemmingSteelborn by Taylor LaRueEmbrace by Bal KhabraThe Cozy Nook Bookshop by Jeannie ChinIn What World by Bridget MorrisseyIt's a Business Doing Pleasure With You by Lindsay LewisRoped by Saffron KentDon't Say Mafia by CR JaneSee you at the Sunset by Susan LeeOld Flames by Nadine GonzalezSex Positive by Brooklyn RoseInternational Relations by Zac HammettHer Undercover Protector by Kayla ParrinThe Marriage Rebound by Meka JamesFull Throttle by JK MaclarenVow of Eternal Night by Lily CrozierSeptember ReleasesLove Me like a Rock Song by Shelley Jay ShoreHexy Beast by Avery FlynnYou're the One that I Haunt by Katie JungA Spell of Heart and Havoc by Kristen ValeThe Alibi Club by Carrie TalickThe Invisible Roommate by Timothy JanovskyFrom Beijing With Love by Bei LinDemons and Diplomacy by Megan FramptonWith all my Haunted Heart by Isabel SterlingIsn't He Romantic by Adib KhorramHow to Ruin a Rake by Kate PearceGhost Me, Maybe by Manda CollinsSee you Next Tuesday by Kate Stayman-LondonGame Over by Bella NorthFormula He's the One by Andie J ChristopherDoomsdate by Laura Piper LeeSponsorsFelicia Grossman, author of Dearest Beast, available in print, ebook, audiobook from Amazon, Barnes & Noble,

Not all good ideas need to be acted on, but all good intentions should.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Whitney Knox Lee.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Whitney Knox Lee.

2 hours and 23 minutes The Sponsors Thank you to Underground Printing for making this all possible. Rishi and Ryan have been our biggest supporters from the beginning. Check out their wide selection of officially licensed Michigan fan gear at their 3 store locations in Ann Arbor or learn about their custom apparel business at undergroundshirts.com. Our associate sponsors are: Peak Wealth Management, Matt Demorest - Realtor and Lender, Ann Arbor Elder Law, Michigan Law Grad, Human Element, Sharon's Heating & Air Conditioning, The Sklars Brothers, Champions Circle, Winewood Organics, Community Pest Solutions, The Aretha Franklin Amphitheatre, Radecki Oral Surgery, Long Road Distillers, and Venue by 4M where recorded this. 1. What Dusty Just Done Did Starts at 0:51 Not only did we have this team come out of nowhere to be the best in the history Michigan basketball. The Dusty May Era is now a fever dream. Takes a little bit out of it. This is college basketball now. Understand why he wouldn't want to be a college coach today; he explicitly said he never got to feel like they won a championship. NCAA can be blamed for letting it get here but also they have no power whatsoever to fix all the things that mean the second you win a title you have to recruit your new team. Second time in a row the college coach the NBA took was Michigan's. This is not the Cavs; Dallas is a good gig. [The rest of the writeup and the player after THE JUMP]  2. The Future of Michigan Basketball Starts at 19:04 They're promoting Mike Boynton to interim head coach, with a possibility of permanence. Greater that 50% chance he's the HC without the interim title, but might execute a search. Five days after they announce a hire the portal is open for Michigan alone, which is probably what scared them into this now. McKenney is back, probably Cadeau back, direction of things is a battle to hold onto the transfer bigs. Boynton: got tagged by the FBI thing, can see his tenure as not successful, or successful for the Minnesota of the Big 12. He has a trademark, which is defense: five of six years with a top-20 unit. Still relatively young, can recruit. Program: "What option do we have?" UNNNNNGGGGGHHHHHH. Actual option: Josh Schertz! Trademark is twos, built a real roster there, is Dusty's best coaching buddy. Don't care as much about roster continuity (Brian Ellerbe, Sherrone Moore) because the players won't be around long. Also if you poach a coach you have access to another team's roster and coaching staff, whereas right now Michigan and the Mavs are competing for Michigan staff and Michigan and the world are competing for Michigan's players. Other names to look at: Niko Medved was our next pick two years ago, did as well as possible with Minnesota last year. Where is Michigan Basketball in program rankings? Would Purdue swap with us? Purdue built their fanbase over years of having a program, just like Michigan hockey. 3. The Warde Talk Starts at 53:17 What are you supposed to do with a guy who alternates between asleep-at-the-wheel scandals and national championships? Push back against Brian's assertion that people "don't want to work for him" because these are all individual situations. He's not a bad guy, but he's also not a guy who *does* things, unless that's milking the fanbase or turning Michigan Stadium into an F1 race of ads. His oeuvre is not doing anything, because that worked with Harbaugh in 2020, and now that's a modus operandi. Talking ADs history since Canham. Push back against Brian's lionizing of Canham: he was a visionary, but his record also includes Dr. Anderson and trying to prevent/undermine Title IX. We end up preferring Bill Martin of all our lifetime ADs—he built the boxes to prevent ads in the stadium. Don't think missing out on Les Miles was a loss. Brian's Warde assessment: He typed "how to AD" into ChatGPT. Does losing Dusty May like this change your opinion on Warde Manuel? No. But it's weird that he keeps surviving (no president to fire him). 4. 2027 Football Recruiting Starts at 1:20:46 Doesn't look any different from a Harbaugh class at this point. If you're good at scouting and developing you're fine. OL class is small but Lipsey stacks another elite tackle and they had to fend off ND for Louis Esposito, Rouleau is a Frey-type. Xavier Muhammad is a very good DT, Tavares Harrington a find at CB, and they held onto some important guys in-state in a good Michigan year. LB recruiting is still underfunded, Brian is fine with that because it's very a "what's in your head" position with no consensus on what schools want. State of the recruiting industry: Paramount got bought and 247 is getting raided as incompetent ownership sets in. On3 is more reactive to scouting this cycle, and almost universally rate M commits higher. White whales: #1 is CB Josh Dobson, Seth Tillman would be a big, big deal because DTs are hard to come by, Monsanna Torbert would be a big win over Ohio State. Lincoln Mageo would be a good OL to finish with. Would like to have more TEs coming in. 5. World Cup Starts at 1:50:04 Takes hotter than Dusty May's agent. Count how many times Brian calls USA "Michigan." Are the Americans the most pleased with their performance in Group Phase (2nd to Canadians). Freeman (son of Antonio) is very reliable defensively, main thing is you can put Dest at wing. Sauciest player in US history? McKenzie is everywhere, runs into the box from deep were especially effective vs Paraguay. Pulisic injury: not going to play him in the useless Turkey game, should be fine. Tim Ream has been trying to play soccer for us forever, always been the best guy on the ball. Decent draw, should be favored (when they make the field) for a couple of rounds. Success point is get to the quarters; they can go into a game against a world power and expect to compete, not win, and not win three in a row. Four years ago they were too young. Don't mind the 48-team format; it saps a lot of tension out of the Group Stage when three teams advance, but a lot of "small teams" have battled. Brazil is still working back to being BRAZIL. Germany is Ohio State but not a peak year Ohio State. France is super talented. Alex: If you play Bosnia and Herzegovina you play two countries at once. Seth: Actually it's more like seven point eight. MUSIC: "Hit or Miss"—Odetta "Take Da Charge"—Project Pat "Love on My Brain"—Jim Ford "Dog Has Its Day"—Toledo “Across 110th Street”—JJ Johnson and his Orchestra   

Our problem isn't with the ego itself - it's just there to protect us - but with the way it separates us from reality.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Whitney Knox Lee.

Evaluating the cost of something is more about the value you get in return than the size of the investment - energetically, financially, and with your time.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Based on the way you're body is designed, everyday activities should not be painful - if it is then something's wrong with what you're putting in or how your body processes it.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

#ELOsoFumarTakes #365thTake   365 episodes.   A full year of Takes.   What started as a passion project has grown into 365 conversations, countless cigars, unforgettable guests, and an incredible community of cigar enthusiasts. We couldn't think of a better way to celebrate this milestone than with two special guests from the world of premium cigars.     We'll be discussing: The all-new AVO Expresivo and what cigar smokers can expect from this exciting release The growing buzz around mocktails at PCA and how they're becoming part of the premium cigar lifestyle Garrison's very first PCA experience and his biggest takeaways from the industry's biggest event The current Era of AVO and how the brand continues to honor the legacy of Avo Uvezian while reaching a new generation of enthusiasts Plus, we'll reflect on what 365 episodes means to us and the amazing journey that got us here   Whether you've been with us since Take #1 or you're just discovering the show, this is one episode you won't want to miss.   Here's to 365 Takes… and the next 365 to come.   #ELOsoFumarTakes #365thTake #AVOCigars #Davidoff #DavidoffGenevaUSA #PremiumCigars #CigarPodcast #CigarLife #PCA2026 #LiveShow #CigarCommunity #CigarCulture #OneYearOfTakes #AVOExpresivo #EraOfAVO

***"We're entering the Bitcoin golden era with all the new technologies we're discovering because for the first decade Bitcoin was still very, at least for the first five, six years, there was so little capital in the industry that not a lot was getting built. Plus Bitcoin still had all these early on issues. Now we're getting to the moment where Bitcoin is extremely solid. It's a trillion dollar industry, right, or a trillion dollar asset. So I think we're just entering the golden era." ~ Gustavo Flores*** I sat down with Gustavo Flores, the CEO of Aureo, Mexico's Bitcoin platform, and this conversation went far beyond just building software. Gustavo actually left Canada for Mexico because of the intense COVID mandates. He recognized the red flags of government overreach early on and refused to stick around. But what he found in Mexico was a completely different beast. We talked about the harsh realities of building a Bitcoin company in a low-trust society where people are conditioned to expect scams. And yet, Gustavo and his team are building some of the most impressive tools I have seen. They figured out a way to route local fiat directly to a self-custodial Lightning address, without even the need of a middleman to hold your keys. It just works. We also talked about the heavy lifting required to run La Casa de Satoshi, a physical Bitcoin hub in Mexico City. It takes a severe amount of irrational optimism to be a founder in this space, but the effort is paying off. Plus, we got into the weeds on why Lightning development is actually moving faster than people think. If you assume the best era of Bitcoin development is already behind us, you need to hear this conversation. Chapters (00:00:00) - Intro to Gustavo and Aureo (00:03:30) - Gustavo's Bitcoin journey and Aureo (00:06:54) - Leaving Canada due to COVID policies (00:15:51) - Bitcoin in Mexico and Latin America (00:27:47) - Money, trust, and Mexican politics (00:32:00) - Aureo's Direct to Wallet, Direct to Bank (00:41:40) - Mexico's political landscape, trust (00:53:07) - Building La Casa de Satoshi community (01:06:14) - Lightning Network and Bitcoin scaling (01:22:48) - Bitcoin's golden era and optimism Guest Links Gustavo on X (Link: https://twitter.com/gustavojfe) Aureo on X (Link: https://twitter.com/aureobitcoin) Aureo's Website (Link: https://www.aureobitcoin.com/en) Affiliate Links Become sovereign, hold your keys, be censorship resistant with the Bitbox hardware wallet. Get 5% off everything in the store with code GUY (Link: https://bitbox.swiss/) Get 10% off the best Bitcoin board game in the world, HODLUP! Or any of the other great games from The Free Market Kids! Use code GUY10 at checkout for 10% off your cart! (Link: https://www.freemarketkids.com/collections/games-1) Host Links ⁠⁠Guy on Nostr ⁠(Link: http://tinyurl.com/2xc96ney) ⁠Guy on X ⁠(Link: https://twitter.com/theguyswann) Guy on Instagram (Link: https://www.instagram.com/theguyswann) Guy on TikTok (Link: https://www.tiktok.com/@theguyswann) Guy's Takes on YouTube (Link: https://www.youtube.com/@GuysTake) Guy Swann on YouTube (Link: https://www.youtube.com/@theguyswann) ⁠Bitcoin Audible on X⁠ (Link: https://twitter.com/BitcoinAudible) The Guy Swann Network Broadcast Room on Keet (Link: https://tinyurl.com/3na6v839)

Split, Essex, Tübingen – Sara hat sich ihren Weg durch die Welt gewiggled. Zusammen mit Lokallegende-Addi geht's um das Leben zwischen Sprachen, Kulturen und Kreativität – und was das alles mit dem eigenen Kopf macht. Sara hat dazu ihre ganz eigenen Takes: ein Kurzfilm ganz ohne Worte, Street Art, Illustration. Überlebt so eine Kunstseele den Agenturalltag oder wird sie dadurch sogar beflügelt? Im Sitzen widmen sich die Artys dem Spagat zwischen persönlicher Kreativität und kommerziellem Kundenwunsch. Denn mit Sara ist endlich jemand im Studio der Addis Sprache spricht – Dänglisch.

Adolf Silva joins us for Chapter 404 of Gypsy Tales.Adolf shares the story of his career in freeride mountain biking, competing at Rampage, and the crash that left him paralyzed. He opens up about recovery, adapting to life after injury, and the mindset that has helped him keep moving forward through the biggest challenge of his life.We also discuss Red Bull Rampage, pushing the limits of mountain biking and action sports, overcoming adversity, finding purpose after injury, and why Adolf refuses to let one moment define his future.00:00:00 Intro 00:04:59 Welcome Adolf Silva to Gypsy Tales 00:10:18 Life post injury00:12:10 How Adolf was Introduced to Action Sports 00:17:19 Life as a KId in California 00:23:50 Adolf's First BMX Bike 00:25:54 Landing Double Backflips in Year One 00:34:21 Living Life One Day at a Time 00:40:33 Adolf's First Major Injury 00:45:34 Adolf's first Rampage Experience 00:48:58 Andreu Lacondeguy's Level of Talent 00:56:34 First Time Competing at Rampage 00:59:12 Crazy Riding Conditions in Utah 01:05:23 What it Takes to Drop in at Rampage01:19:35 Adolf;s FMX Career 01:26:02 Life Changing 2025 Rampage Crash 01:32:40 Remembering the crash 01:40:24 Adolf's Friendship with Axell Hodges 01:42:16 Realising He Was Paralysed 01:48:38 Refusing to Live in the Negative 01:58:19 Becoming a Better Man Through Adversity02:03:14 Adolf's Appreciation for His Wife 02:04:16 The Biggest Struggle Post Injury 02:07:23 The Support of Road 2 Recovery 02:09:13 Competing in HYROX 02:17:52 ClosingIf you enjoy this chapter, be sure to like, subscribe, and turn on notifications so you never miss a Gypsy Tales podcast! Monster Energy

What it Takes to Be an Authentic, Embodied and Sustainable Leader While Staying Aligned With Your Core Values with Barbara San-Roman

What it Takes to Be an Authentic, Embodied and Sustainable Leader While Staying Aligned With Your Core Values with Barbara San-Roman

Just because you assume the identity of being a morning person doesn't guarantee you'll have the experience of starting the day fast with lots of energy. Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

THE BREAK ROOM, WCMF, Friday 6/19, 9am Hour 1) Time for a middle class reveal. Where do you stand? Takes from Tommy the “Boomerific.” 2) Summer of Live ticket sale. Darien Lake, Empower Amphitheater and SPAC running 4 for $99 deals!

Dennis is filling in for Bloomdaddy reliving and discussing the 10th anniversary of the Cavaliers capturing their first ever NBA Championship vs the Warriors in 2016. Takes calls and memories of that day. Guardians Manager Stephen Vogt joins the program from Houston to talk Guardians ahead of their weekend series vs the Astros. World Cup Fever, Obama Presidential Library and more!

Air Date: 6/17/2026 Today we trace a pattern that repeated across half a dozen states this primary season: working-class candidates running on the cost of living beat the opponents party leadership hand-picked and funded. It looks like ordinary election news, but it's more pieces of a larger shift already underway; away from a politics of left against right and toward a new era of the elite vs working people. Full Show Notes Transcript Be part of the show! Leave a voice message, message us on Signal at the handle bestoftheleft.01, or email Jay@BestOfTheLeft.com BestOfTheLeft.com/Support (Members Get Bonus Shows + No Ads!) Use our links to shop Bookshop.org and Libro.fm for a non-evil book and audiobook purchasing experience! Join our Discord community! TOP TAKES KP 1: Hayes: Trump Is Chasing Good Press with Bombs - All In with Chris Hayes - Air Date 6-11-26 KP 2: Bernie Sanders Just Won Them All - The Rational National - Air Date 6-10-26 KP 3: We Sat AOC Down With Republican Voters. Can She Win Them Over? - More Perfect Union and Alexandria Ocasio-Cortez - Air Date 6-9-26 KP 4: "Fetterman Vibes?" DSA Dem WON'T DEFEND Graham Platner - Breaking Points - Air Date 6-9-26 KP 5: Abdul El-Sayed Thinks the Michigan Senate Race Will Come Down to This One Factor - Slate and Abdul El-Sayed - Air Date 4-30-26 (00:49:39) NOTE FROM THE EDITOR Counterfeit Populism Is Dying My commentaries on YouTube - Share them! DEEPER DIVES (01:05:26) SECTION A: READING THE PRIMARY MAP A1: Voters Reject the Establishment in This Week's Primaries - The NPR Politics Podcast - Air Date 6-4-26 A2: Josh Turek, Democratic Senate Nominee, on Why Iowa Will Flip Blue - Brian Tyler Cohen News - Air Date 6-3-26 A3: The Graham Platner Debate Part 1 - Majority 54 - Air Date 6-4-26 A4: Kentucky Senate Seat Is 'most Flippable' Race, Says Democrat Charles Booker - Meet The Press NOW _ NBC News NOW - Air Date 5-19-26 A5: The Democratic Establishment Can Be Defeated - Current Affairs - Air Date 5-15-26 (01:45:20) SECTION B: THE PLATNER RECKONING B1: How Maine Democrats View Platner's Scandals and Chances to Oust Sen. Collins - PBS NewsHour - Air Date 6-9-26 B2: Graham Platner's Billionaire-Bashing Message Resonates in Maine Senate Race, Despite Controversies - Democracy Now! - Air Date 6-8-26 B3: Why I Left the (White) Left - Signified B Sides - Air Date 6-2-26 B4: We Need to Talk About The Graham Platner Left (ft@noahsamsen_) - The Kavernacle and Noah Samsen - Air Date 5-27-26 B5: The Graham Platner Debate Part 2 - Majority 54 - Air Date 6-4-26 (02:30:13) SECTION C: THE TEXAS SENATE FIGHT C1: Talarico Derangement Syndrome & Calling Stephen Miller Ugly Part 1 - Head in the Office - Air Date 5-29-26 C2: Can We Win Texas? - Majority 54 - Air Date 5-28-26 C3: Talarico Derangement Syndrome & Calling Stephen Miller Ugly Part 2 - Head in the Office - Air Date 5-29-26 (02:56:11) SECTION D: DEFENDING THE VOTE & THE LONG VIEW D1: MAGA's California Fraud Lie Falls Apart Instantly - All In with Chris Hayes - Air Date 6-9-26 D2: Their Votes Should Count. Yours Shouldn't. That's the Whole Argument. - Takes™ by Jamelle Bouie - Air Date 6-9-26 D3: The Election Interference Evidence No One Is Talking About - The Real News Podcast - Air Date 6-8-26 D4: The Washington Roundtable Live: The Backlash Midterms - The Political Scene | The New Yorker - Air Date 6-5-26   Produced by Jay! Tomlinson Visit us at BestOfTheLeft.com Listen Anywhere! BestOfTheLeft.com/Listen Listen Anywhere! Follow BotL: Bluesky | Mastodon | Threads | X Like at Facebook.com/BestOfTheLeft Contact me directly at Jay@BestOfTheLeft.com

Brand new hospitality unit perfect for F1 drivers, engineers and mechanics.  Three floors, two kitchens, multiple meeting spaces, lounges, racing sim room and roof terrace.  Great central F1 Paddock location. Close to racetrack, garages and media centre.  Comes with chef and two coffee machines.  Takes just two days to build and deconstruct.  Can be moved wherever you need it (Europe only) by truck. Ideal for European racetracks with no permanent team buildings For inquiries please contact Christian Hewgill or Audi Racing Director Allan McNish who can answer all the questions you have about this and other Formula 1 team motorhomes hospitality units.F1 Explains is here to answer your F1 questionsSend them to F1Explains@F1.comListen to more official F1 podcastsIncredible personal stories on F1 Beyond The Grid - including Allan McNish on his F1 careerExpert race previews and reviews - right here on the F1 Nation podcast feed

With AI adoption exploding, what does that actually mean for how you grow your team, your donors, and your impact?Naria Santa Lucia brought SO much energy and joy to her MC role at the Microsoft Global Nonprofit Leaders Summit, that I had to sit down with her to hear how nonprofit leaders can build practical pathways for using AI in their day-to-day work and cut through the hype.Naria also brings a perspective every nonprofit needs to hear: take the big swing, stay true to your mission, and don't pivot just to chase funding. When you focus on real impact (and communicate it clearly!) you'll draw the right supporters in.Resources & LinksConnect with Naria Santa Lucia on LinkedIn and learn more about Microsoft Elevate here.Not sure where to start in building your program? Start with this $5 audit to know where your gap is. Takes 5-10 minutes max, and you'll know where to start --> Monthly Giving Interactive Audit  Bloomerang is the proud presenter of Missions to Movements. See how one team surpassed a $1M match and raised $2.25M for their mission with Penny, Bloomerang's AI-powered fundraising strategist. Learn more at bloomerang.com.The Monthly Giving Builder: Generate your comprehensive monthly giving plan and build your program step by step - with a guided companion working alongside you from start to finish. Let's Connect!Send a DM on Instagram or LinkedIn and let us know what you think of the show!My book, The Monthly Giving Mastermind, is here! Grab a copy here and learn my framework to build, grow, and sustain subscriptions for good.Want to book Dana as a speaker for your event? Click here!

Graduates are flooding hiring desks with AI-generated resumés. Hiring managers see right through it. Takes two seconds. Why they're getting the boot and what actually works. Plus, I help Darrel save hundreds of dollars on fluctuating flights, hotels and rental car prices. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to this Methanol Market Puts-and-Takes podcast episode, part of the Chemical Conversations series.  In this episode, Senior Analyst Cassidy Staggers talks with Dave McCaskill, Argus VP of Methanol and Derivatives on: Impact of the Iran–US peace agreement on the methanol industry Potential for softer pricing in Asia and slower declines in the Atlantic basin A longer-term outlook for the global methanol market Argus offers methanol prices, news, analysis, forecasts, and consulting. Get more information and request a free trial.

Bloomdaddy talks recent comments made by Mike DeWine about abolishing the Death Penalty. Tom Moore pops in to give his thoughts on it, as well as talks witnessing someone being put to death. Takes calls on the topic, a Tuesday Tirade, and more.

It's very possible that an environment influences you to make a semi-conscious decision that you later disagree with.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Some of Kyle Brandt's Best Cuts from the Week of 6/8/2026: Patriots AFC Favorites? Mayfield Future Seahawks still contenders Starting the #1 overall pick Trouble for Texans? Bears surprise hope Kyler Murray starting Moore for the Bills New Look Ravens 10 Takes with Kyle Brandt is part of the NFL Podcast Network See omnystudio.com/listener for privacy information.

This Week's EpisodesEnvironmental Interventions Surrendering To Life What Is Your 4%? The Only Three Things You Can Do To Manage Stress The Difference Between Knowledge And Wisdom Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

There are only 3 things you can do in the face of life events: Control, influence, or accept.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

When life pulls you a certain direction, try not to resist it and surrender to the way it's unfolding.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

The Boys partner up with a returning Outlaw Vern to talk MASTERS OF THE UNIVERSE (2026). Mike, & Vyce have Takes and Sermons, while Liam talks MOTU business. Meanwhile, Producer Max looks back at some Action Blindspots like Albert Pyun's first feature THE SWORD AND THE SORCEROR, and some 90's action with SPLIT SECOND! All that and more await in the latest episode of Action For Everyone!Find Us on these Platforms:Guest- Outlaw Vern: Twitter, Bluesky, Instagram,  OutlawVernThe Boys-Action For Everyone: Twitter/BlueSky/Twitch/InstagramMichael Scott: BlueSkyVyceVictus: Twitter/BlueSky/Instagram/LetterboxdLiam O'Donnell: Twitter/InstagramMax Deering: Twitter/Bluesky/Letterboxd/Polygon/Neonsplatter/Fangoria/DiscussingFilm, Muckrack

Some of the best cuts from Kyle Brandt from the Week of 6/1/2026: Big deal for Patriots Vikings QB Competition Let Cam be Cam Lions Optimism A Rams Comeback? New Madden Cover Patriots AFC Repeat? Difference between a star and a #2 10 Takes with Kyle Brandt is part of the NFL Podcast Network See omnystudio.com/listener for privacy information.

This Week's EpisodesThe Cake Metaphor Of Changing Your Life Don't Waste A Good Crisis The Similarities Between New Year Resolutions And Finding Purpose The Thing You're Avoiding Isn't As Hard As You Thought It Would Be Get Outside Of The Box To Think Outside Of The Box Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Takes in our community are just.. trash. The boys discuss some of the worse along with Universal GB, B&M changing up where they make their steel, Walibi Belgium getting an RMC, fan questions and more in this episode.

The ideas you come up with are naturally derived from your present circumstances - you need to get outside of the box to think outside of the box.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

This week on America's podcast, we dive into a band that inspired a whole generation of punk, pop-punk, and “I swear I can still fit into my old leather jacket” bands — Social Distortion and their classic album Somewhere Between Heaven and Hell. It's just the Three Amigos on this episode — brothers in podcasting and brothers in surviving questionable music takes. No family members this week… so things might actually stay on track for once. Will this album send us straight to heaven, or will it be pure hell on the ears? No spoilers… but somebody may need emotional support hairspray by the end of the show. Tracks of the Week Mooger — Star Star by Joan Jett (the The Rolling Stones cover) Marc — All You Zombies by The Hooters Jerry — Dancing with Myself by Billy Idol Make sure to leave us a five-star review on Apple Podcasts, follow us on Podbean and Podchaser, and check out our YouTube channel https://www.youtube.com/@freeformrockpodcast9076 So you don't miss the After Shows, Jerry's Takes, Mooger's Minutia Minutes, Marc's Quick Thoughts, live concert clips, and whatever other madness we decide to throw online. Until next week, make sure you don't get put away for 99 to life. Enjoy your life, rock on, headbang, get in the pit, live loud, listen to this podcast, and share it with your fellow rock degenerates. Free Form OUT!

The idea of something is often much more complicated or difficult than the reality of doing it - and the only way to discover the difference is to get started with it. Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

BJ Spaulding took a chance and became a novelist after years of a productive writing career. His book 'Who's To Blame?" Takes a look a faith, and dealing with the tragedies of life with an open heart and fresh perspective

Our natural tendency is to adopt an all or nothing mindset but it sets us up for failure, particularly as it relates to changing our lives and changing the world.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Why do discovery calls eat your time and still end with “let me think about it”?In this episode, you'll hear how Meagan Bukowski stopped relying on follow-up sales calls and built a product ladder that does the qualifying and selling for her.Instead of pushing a “$1,000/mo offer,” she solved one small, urgent problem first – paid.That first yes led naturally to the next step, and then ongoing work. It's a clear, real example of how to earn trust, protect your time, and grow revenue without chasing prospects.…Link to full shownotes: https://www.businessstrategyforcpas.com/393…Want Pricing Essentials?If you feel trapped by your own accounting firm, it's not because of the work – it's how you've priced the work. Too many accountants are stuck in undercharging, overdelivering, and people-pleasing cycles. Break the pattern with my short PDF guide: 7 Pricing Essentials »It's free and you can read it in 5 minutes.I want to help you get your prices up without losing loyal clients.  …Want client interviews?310 From Exhausted to Having Her Life Back: Wendy Norman, CPA304 From 55 Down to 15 Hours; Same Take-Home Pay with Melissa Downs, EA293 What it Takes to Work 15 Hours per Week with Erica Goode, CPAComplete list:geraldinecarter.com/client-interview-episodes…FOUR ways I help overworked CPAs go down to 40 hours without losing revenue or hiring:THE EMAIL COURSE – Freegeraldinecarter.com/stop-working-weekendsStop Working Weekends will teach you how to reduce your hours without giving up revenue. THE BOOK – $9.99geraldinecarter.com/bookDown to 40 Hours – A Roadmap for CPAs to End Overworking Without Losing RevenuePEAK FREEDOM COMMUNITY – $197/mogeraldinecarter.com/peak-freedomFor solo and small accounting firm owners who want to rise above the insanity of hustle-cultureDOWN TO 40 HOURS ACCELERATOR – $995/mogeraldinecarter.com/40For the overworked CPA at multiple six figures of revenue who is ready to stop working weekends, wants to implement overdue changes, and doesn't want to do it alone. You'll make progress faster and with more confidence. …

The challenging things that happen to you are a fertile soil for growth and transformation when you lean into them.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

50 SOS Takes in 50 Minutes | Episode 481Welcome to Lords of Limited, the podcast dedicated to getting you better at drafting in Magic: the Gathering. This week, we're sending off Secrets of Strixhaven with 50 takes in 50 minutes. We've got our wrap-up thoughts on what worked (and what didn't) in this Back to School set, the dominating macro-archetypes, tons of power rankings, Golden Egg and Imperial Oath Awards, and More!

Today would have been the 100th birthday of film star and pop culture icon Marilyn Monroe. To celebrate the centennial, Andrew Wilson discusses his new biography, I Wanna Be Loved By You: Marilyn Monroe, A Life in 100 Takes. Plus, listeners share their favorite Marilyn Monroe films, and their memories of her life and career. Photo by Baron/Hulton Archive/Getty Images: Actress Marilyn Monroe poses for a portrait laying on the grass in 1954 in Palm Springs, California.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

ACOFAE Podcast presents: Heated Rivalry: "All romance feels like fantasy at this point." Shane Hollander. Ilya Rosenov. You know the names. You've probably seen the show, and the books are more than likely on your radar. It's Pride so let's let the boys have some fun as ACOFAE discusses book 2 in the Game Changer series by Rachel Reid, Heated Rivalry. A first for Laura Marie, (a sports romance!) Takes readers on one of the longest situationship rides ever as these two hockey players from difference countries and teams fall in love. An MM romance that is sweet and tender, as well as poignant and subtle, Shane and Ilya will stay with you long after the book is finished. Longtime listeners will not be surprised to learn that Jessica Marie has been all over this series and has the books to prove it. TW / CW: discussions surrounding homophobia For additional TW/CW information for your future reads, head to this site for more: https://triggerwarningdatabase.com/ Spoilers: Heated Rivalry (book and show), Game Changers (book 1), ACOSF Mentions: The Devil Wears Prada, Pose, Brokeback Mountain, Euphoria *Thank you for listening to us! Please subscribe and leave a 5-star review and follow us on Instagram at @ACOFAEpodcast and on our TikToks! TikTok: ACOFAELaura : Laura Marie ( https://www.tiktok.com/@acofaelaura) ACOFAEJessica : Jessica Marie (https://www.tiktok.com/@acofaejessica) Instagram: @ACOFAEpodcast https://www.instagram.com/acofaepodcast/ @ACOFAELaura https://www.instagram.com/acofaelaura/ “Lost in the sauce.”

On this week's show, Stan falls back in love with Modern MTG, we continue to guide Dave on his fashion journey, Shane gears up for the Antique Roadshow, and we shake our fists at prediction markets for spoiling Survivor results. Become a citizen of The Dive Down Nation!: http://www.patreon.com/thedivedown Show the world that you're a proud citizen of The Dive Down Nation with some merch from the store: https://www.thedivedown.com/store Upgrade your gameplay and your gameday with Heavy Play accessories. Use code THEDIVEDOWN for 10% off your first order at https://www.heavyplay.com Get 25% Cashback after 3 months of service with ManaTraders! https://www.manatraders.com/?medium=thedivedown and use coupon code THEDIVEDOWN And now receive 8% off your order of paper cards from Nerd Rage Gaming with code DIVE8 at https://www.nerdragegaming.com/ Timestamps: 0:01 - Disguising our moms at Antiques Roadshow 8:24 - What should Shane take to Roadshow? 14:52 - This week's episode 15:45 - Dave's clothes 23:47 - Stan is playing Magic Online again 34:18 - Shane is scared of RE9 39:28 - Metaphor: still ReFantazioing 42:56 - Survivor 50: Spoiled by Kalshi? 50:40 - Takes on The Truman Show (1998) 1:00:04 - Public comments: what game changed our relationship with gaming? 1:04:57 - Wrapping up Our opening music is Nowhere - You Never Knew, and our closing music is Space Blood - Goro? Is That Your Christian Name? email us: thedivedown@gmail.com

Making decisions and acting from a place of love isn't foolproof, but it's the best source of navigation that we've got.Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Just as a heads up: This episode was posted on the Takes feed over the weekend, but I wanted to make sure and share it with y'all because a.) it was a lot of fun and b.) I did a weirdly large amount of work for it, having to rewatch three films and read a bunch of stuff. But I wanted to make sure you guys heard it in case you haven't subscribed to the Takes feed. (And if you haven't, for shame! You're missing JVL and me riffing on the terrible America 250 concert!)

Be inspired by others who hold themselves to a higher standard but don't blindly copy - it's important to still get clear on where you want to keep yours. Was this helpful? If so then you need to check out the 7 Fundamentals Of Self Improvement which features short summaries of the most popular and impactful episodes from the past 7 years.Takes only 5 minutes to read through them today but it'll help you avoid years of making things so much harder than they need to be. Plus, I bet you'll be surprised to learn what they are...

Anticipate a deep dive into new Takes. Who even goes first? It's a strategic take session that sees a lot of retrospect and a lot of money. Support us directly at https://www.patreon.com/TheRegulationPod Stay up to date, get exclusive supplemental content, and connect with other Regulation Listeners. Learn more about your ad choices. Visit megaphone.fm/adchoices