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In this episode, Prof Chapman explains ovarian tissue cryopreservation, including who it is genuinely suitable for, why it remains largely an experimental fertility preservation technique, and its role for women facing urgent cancer treatment. He also answers a detailed question from a patient who has received a strong positive beta hCG result following embryo transfer. Prof Chapman discusses whether repeat blood tests are necessary, what healthy hCG progression should look like, the importance of early viability scans, and how pregnancy milestones at 7, 10, and 12 weeks help predict the likelihood of a successful outcome. A reassuring discussion for anyone navigating the anxious early days of pregnancy after IVF. Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF). Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.
In this episode, Ethan sits down with Paige to talk about one of the hardest parts of losing weight: keeping it off. Ethan shares the mindset shift that finally changed things for him, moving away from chasing diets and toward understanding energy balance, maintenance, and long term habits.They talk about years of experimenting with HCG and keto, the unexpected lessons that came from challenging old beliefs about food, and why changing your body does not automatically change the way you see yourself. Ethan also opens up about identity after weight loss, self criticism, and the habits that can stay long after the scale changes.Plus, Ethan answers a listener question about OMAD, protein intake, and how to approach fat loss while preserving muscle.Subscribe to Ethan's newsletter here: Ethan Suplee NewsletterSHOW HIGHLIGHTS00:00 - Introduction02:46 - How I finally made weight loss stick06:28 - Why maintenance is harder than dieting09:56 - Learning energy balance changed everything13:34 - HCG, keto, and years of chasing results18:39 - The gym conversation that shifted my thinking22:35 - Reading Bigger Leaner Stronger and changing approach24:55 - Diet Coke guilt and inherited beliefs about food30:28 - Why results matter more than food rules36:00 - The hidden part of weight loss: identity39:22 - Still feeling like the old version of yourself42:08 - Practical ways to challenge negative self-talk49:44 - Does that feeling ever go away?50:41 - Why action helps more than overthinking53:49 - Listener Q&A: OMAD, protein, and maintaining muscle58:15 - Tips for fitting protein into a limited eating window Hosted on Acast. See acast.com/privacy for more information.
Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to no produced adverse-safety evidence, and describes the patient impact and advocacy around a July PCAC meeting. He explains most peptide APIs and many compounded GLP-1 ingredients come from China, while pharma-grade GLP-1s have more U.S. production. The discussion covers retatrutide's potential biologic classification (40–amino acid rule) and pricing implications, MOTS-c as an adjunct for low energy on GLP-1s, skepticism about cardarine, growth hormone secretagogues and cancer fears, TRT dosing frequency, sleep apnea screening, HCG's roles, and penis enhancement via traction for length and hyaluronic acid filler for girth, emphasizing expectations and mental health. Dr. Alex Tatem is a board-certified urologist focused on men's health, hormone optimization, male fertility, and sexual wellness. In this episode, he joins Dr. Mike Hart to discuss the changing landscape of peptide therapy, including FDA restrictions, compounding pharmacies, drug supply chains, and the growing debate around access to treatments such as BPC-157, MOTS-c, and retatrutide. He also breaks down practical considerations for men using testosterone replacement therapy, including HCG, fertility preservation, dosing frequency, estrogen-related side effects, and sleep apnea risk. Drawing from his experience treating a wide range of patients, he shares a harm-reduction approach to performance medicine and explains what men should understand before considering growth hormone peptides, GLP-1 medications, or penile enhancement procedures. Dr. Alex Tatem Website https://dralextatem.com/ Dr. Alex Tatem Instagram https://www.instagram.com/dralextatem/ Huberman Lab — Peptides: The Science, Uses & Safety | Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri FDA Pharmacy Compounding Advisory Committee Meeting — July 23–24, 2026 https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026 FDA Bulk Drug Substances Under Section 503A https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-503a-fdc-act FDA Compounding Safety Risks https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Semaglutide / Ozempic https://medlineplus.gov/druginfo/meds/a618008.html Tirzepatide / Mounjaro https://medlineplus.gov/druginfo/meds/a622044.html Retatrutide Clinical Trial https://clinicaltrials.gov/study/NCT05929066 Testosterone Cypionate https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=testosterone%20cypionate Human Chorionic Gonadotropin / HCG https://pubmed.ncbi.nlm.nih.gov/?term=human+chorionic+gonadotropin BPC-157 https://pubmed.ncbi.nlm.nih.gov/?term=BPC-157 KPV Peptide https://pubmed.ncbi.nlm.nih.gov/?term=KPV+peptide TB-500 / Thymosin Beta-4 https://pubmed.ncbi.nlm.nih.gov/?term=thymosin+beta-4 MOTS-c https://pubmed.ncbi.nlm.nih.gov/?term=MOTS-c CJC-1295 https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295 Ibutamoren / MK-677 https://pubmed.ncbi.nlm.nih.gov/?term=ibutamoren+MK-677 Cardarine / GW501516 https://pubmed.ncbi.nlm.nih.gov/?term=GW501516+cardarine PhalloFILL at Urology of Indiana https://menshealthin.com/services/phallofill/ Hyaluronic Acid Penile Girth Enhancement Overview https://auanews.net/issues/articles/2024/august-extra-2024/office-and-surgical-technologies-the-evolving-landscape-of-penile-girth-enhancement Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 Are Peptides Threatening Pharma 01:17 Patent Law and FDA Categories 02:19 The 2023 Peptide Ban Fallout 03:59 Safety or Money Debate 06:09 China Supply Chain Exposed 11:33 RFK Jr Peptide Messaging 16:01 Retatrutide Biologic Fight 20:51 What Biologic Status Costs 25:27 MOTS-c as GLP-1 Booster 28:43 Growth Hormone Cancer Myth 32:18 Sleep Effects and Bryan Johnson 35:04 Microplastics and Saunas 36:48 Cardarine Cancer Risk 40:07 TRT and HCG Basics 45:08 HCG Dosing Nuance 49:06 Daily TRT Microdosing 52:03 Sleep Apnea on TRT 56:34 Penis Enhancement Options 01:02:54 Realistic Expectations 01:04:46 Wrap Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
A guide to diagnosing, imaging, and managing acute renal colic and nephrolithiasis in the ED. Hosts: Brian Gilberti, MD Avir Mitra, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Nephrolithiasis.mp3 Download Leave a Comment Tags: Kidney Stones, Urology Show Notes 1. CLINICAL CORE & PHYSIOLOGIC FRAMEWORK Epidemiologic Risk Profiles Lifetime incidence parameters hover around 1 in 11, presenting with a prominent male sex skew. Peak demographic manifestation concentrated within the 30–60 age band. High-yield temporal parameter: 50% recurrence vector within a 5-year post-initial-insult window. Mineralogical Composition Vectors Calcium oxalate crystals represent the predominant structural matrix. Struvite configurations (magnesium ammonium phosphate matrix) account for 1–2% of cohorts. Struvite stones function explicitly as infection-driven configurations secondary to upper tract proliferation; higher distribution index noted in female cohorts. Etiological & Modifiable Relational Dynamics Profound systemic dehydration or low baseline fluid throughput states. High-sodium diet structures and heavy animal-protein consumption loads. Positive genetic/familial history variables. Relative risk modulation: Each variable independently operates to expand baseline risk by a factor of 2x to 3x. Pathophysiologic Symptom Complexes Acute, sudden-onset, maximum-intensity (10/10) unilateral flank pain. Classic structural radiation vector tracking downward toward the ipsilateral groin/genitourinary dermatomes. Distinctive behavioral marker: Renal colic pacing/writhing behavior with zero antalgic position availability. Concomitant autonomic triggers: Nausea and emesis manifest in 50% of acute presentations. Physical Exam Discordance Metrics Severe subjective distress contrasted with a characteristically soft, completely non-tender abdominal palpation exam. CVA tenderness is completely variable and lacks reliable negative predictive value. Atypical Presentation Classifications Vague, poorly localized abdominal pain presentations occurring in up to 20% of active cases. Isolated lower urinary tract irritative signs including acute frequency or severe urgency. Incidental & Asymptomatic Dynamics Silent intrarenal or ureteral stones found incidentally. Longitudinal tracking demonstrates up to 33.3% of initially asymptomatic cohorts convert to fully symptomatic renal colic within a multi-year tracking window. 2. EXCLUSION DIAGNOSES & CRITICAL PATHWAY RED FLAGS Vascular Mimics: AAA rupture/expansion. This is a mandatory exclusion pathway in elderly cohorts presenting with acute flank or back pain. Physical tracking requires active exploration for an expansile, pulsatile abdominal mass. Gynecologic Emergencies: Ruptured ectopic pregnancy. Demands universal screening protocols via rapid beta-hCG testing in all female patients of childbearing potential presenting with lower abdominal/pelvic localization. Infectious Upper Tract Decompensation: Acute uncomplicated pyelonephritis. Differentiated via persistent high spikes, high fevers, systemic shaking chills, and profound pyuria. Genitourinary Structural Crises: Acute testicular torsion. Mandates a thorough, explicit scrotal/testicular structural exam if the flank pain radiates into the scrotum. Gastrointestinal and Adnexal Torsional Confounds: Acute appendicitis variants, acute mesenteric/bowel ischemia, and ovarian torsion syndromes. 3. LABORATORY TESTING & PHYSIOLOGIC EVALUATION Urinalysis Interpretation Nuances Microscopic or gross hematuria presents in approximately 66% to 90% of acute cases. Critical Pathological Caveat: Complete absence of hematuria documented in 20% to 33.3% of confirmed, acute obstructing ureteral stones. Diagnostic rule: A pristine urinalysis with zero red blood cells is entirely insufficient to exclude acute ureterolithiasis. Urinary pH as a Composition Clue Consistently low urinary pH parameters (pH < 5.5) point strongly toward a uric acid crystalline composition. Elevated urinary pH parameters (pH > 7.5) indicate the presence of urease-producing microbial pathogens, pointing toward a struvite infection stone. Infectious Screening Metrics Active tracking for marked pyuria, positive leukocyte esterase, and bacterial nitrites to rule out an obstructed, infected upper urinary tract system. BMP Immediate quantification of baseline serum creatinine to establish accurate eGFR values. Targeting detection of post-renal AKI from bilateral obstruction, unilateral obstruction in a single functioning kidney, or severe volume depletion. CBC Evaluation for marked leukocytosis. Physiologic Nuance: Mild-to-moderate white blood cell count elevations frequently represent non-specific stress demargination driven by severe pain and repetitive vomiting. High-grade white blood cell shifts demand immediate exclusion of systemic bacteremia or an infected, obstructed urinary system. Adjunctive Lab Pathways Rapid qualitative urine hCG testing. Reflex urine culture execution whenever urinalysis metrics display significant inflammatory profiles or clinical suspicion of UTI is high. 4. IMAGING MODALITIES & ALGORITHMIC CLINICAL SELECTION Non-Contrast CT Diagnostics Gold standard; diagnostic sensitivity and specificity parameters exceed 95% for stones >2 mm. Provides precise quantification of stone diameter (mm), exact localization (proximal, mid, or distal ureter), and degree of secondary hydronephrosis. Excellent structural visualization for detecting or ruling out alternate retroperitoneal, vascular, or intra-abdominal pathologies. Contrast-Enhanced CT Protocols Indicated when alternative intra-abdominal surgical pathology is highly suspected over isolated renal colic. Retains diagnostic capability to identify urinary tract stones >3 mm even within contrast-enhanced phases. NCCT Structural Architecture Limitations Standard stone protocol CT scans are executed in a prone position without IV contrast enhancement. It does not opacify the ureteral lumen. Presents a cumulative radiation exposure penalty when utilized serially across recurrent ED presentations. POCUS / Radiology Ultrasound Direct stone visualization capabilities are modest, operating at approximately 50% to 60% sensitivity, and is highly dependent on anatomical positioning at the extreme proximal ureter or the UVJ. Secondary obstruction tracking: Demonstration of hydronephrosis operates at a high sensitivity of approximately 80%. POCUS Clinical Utility Metrics Eliminates ionizing radiation exposure and allows immediate, rapid real-time execution directly at the patient’s bedside. Confirmation of significant hydronephrosis within a classic clinical presentation yields high post-test probability for stone presence while lowering suspicion for vascular catastrophes like a AAA. KUB Radiography Extremely poor overall diagnostic sensitivity, hovering around 57%. Fails to image radiolucent configurations (pure uric acid matrices) or small stones measuring
In this week's episode, Gretchen shares the news that she is pregnant, and gets very honest about what pregnancy after loss actually feels like.She talks through conceiving after her January miscarriage, the anxiety of waiting on bloodwork, checking HCG and progesterone levels, seeing the heartbeat, and the emotional whiplash of feeling deeply grateful and absolutely terrified at the same time. Gretchen also shares how different this pregnancy feels from Lennon's, from brutal nausea and food aversions to the gender results sitting unopened in her inbox.This episode is raw, hopeful, and very real. If you've ever experienced pregnancy after loss, miscarriage, intrusive thoughts, or the fear of celebrating too soon, this one will feel honest, comforting, and a little less lonely.
APR Health Solutions Peptides: www.aprhealthsolutions.com - code nyleOptimize HRT Clinic: https://members.optimize-hp.com - code nyleMerch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'nyle' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘nyle' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program: https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle (code nyle)Timestamps:00:00:00 Intro00:02:04 Sarcoplasmic vs. Myofibrillar Training00:06:11 Overtraining & Serbian Diet00:08:20 High-Protein Strategy & Food Visualization00:14:12 The Five-Year Plan & Olympia Regrets00:16:27 Training Back with Ronnie Coleman00:20:20 Arm Blasting & Training Splits00:23:44 Training Long vs. Training Hard00:26:16 Modern Stress & Recovery00:28:02 Giant Sets & Peak Contractions00:32:45 Gym Ethics & The Colosseum Rule00:35:03 Peptide Optimization & Liver Protection00:37:05 IGF-1 Protocols & Injection Science00:41:45 Needle Length & The Golden Era of 199700:45:52 Nile's Quad Protocol & Leg Sweeps00:49:57 V-Taper, Waist Size, & Classic Criteria00:55:41 The Oncology Risks of IGF-101:01:12 Debunking the Insulin Myth with Dave Palumbo01:13:10 Pre-Workout Insulin & Nutrient Loading01:22:07 Optimize HRT & Bloodwork Management01:25:54 Low-Dose Thyroid Hormones (T3/T4)01:34:59 Longevity, Joint Health, & Synthol Disasters01:39:58 Cruising vs. "Half On, Half Off" Cycles01:44:08 Off-Cycle Training & Muscle Memory01:52:00 Peptides (BPC-157/TB-500) & The Placebo Effect02:02:18 Post-Show Rebound Strategy02:09:14 Jean Pierre Fux vs. Marcus Ruhl02:13:51 DHB (Dihydroboldenone) vs. Masteron/Primo02:16:35 Milos' Maximum Cycle Dosages02:18:14 Posing Artistry vs. Bodybuilding Judging02:22:08 Terrible Genetics & Overcoming Limitations02:24:33 1999: Milos' Biggest Year & Synthol Regrets02:28:21 The Holy Trinity: Test, GH, & Insulin Synergy02:28:55 Masteron vs. Primobolan Contest Selection02:30:26 Steve's "Bathmate & hCG" Protocol02:32:43 Generic vs. Pharmaceutical Growth Hormone02:36:45 Most Underrated & Overrated PEDs02:38:23 Final Message: Legacy, Love, & Simplicity00:00:00 Intro00:02:04 Sarcoplasmic vs. Myofibrillar Training00:06:11 Overtraining & Serbian Diet00:08:20 High-Protein Strategy & Food Visualization00:14:12 The Five-Year Plan & Olympia Regrets00:16:27 Training Back with Ronnie Coleman00:20:20 Arm Blasting & Training Splits00:23:44 Training Long vs. Training Hard00:26:16 Modern Stress & Recovery00:28:02 Giant Sets & Peak Contractions00:32:45 Gym Ethics & The Colosseum Rule00:35:03 Peptide Optimization & Liver Protection00:37:05 IGF-1 Protocols & Injection Science00:41:45 Needle Length & The Golden Era of 199700:45:52 Nile's Quad Protocol & Leg Sweeps00:49:57 V-Taper, Waist Size, & Classic Criteria00:55:41 The Oncology Risks of IGF-101:01:12 Debunking the Insulin Myth with Dave Palumbo01:13:10 Pre-Workout Insulin & Nutrient Loading01:22:07 Optimize HRT & Bloodwork Management01:25:54 Low-Dose Thyroid Hormones (T3/T4)01:34:59 Longevity, Joint Health, & Synthol Disasters01:39:58 Cruising vs. "Half On, Half Off" Cycles01:44:08 Off-Cycle Training & Muscle Memory01:52:00 Peptides (BPC-157/TB-500) & The Placebo Effect02:02:18 Post-Show Rebound Strategy02:09:14 Jean Pierre Fux vs. Marcus Ruhl02:13:51 DHB (Dihydroboldenone) vs. Masteron/Primo02:16:35 Milos' Maximum Cycle Dosages02:18:14 Posing Artistry vs. Bodybuilding Judging02:22:08 Terrible Genetics & Overcoming Limitations02:24:33 1999: Milos' Biggest Year & Synthol Regrets02:28:21 The Holy Trinity: Test, GH, & Insulin Synergy02:28:55 Masteron vs. Primobolan Contest Selection02:30:26 Steve's "Bathmate & hCG" Protocol02:32:43 Generic vs. Pharmaceutical Growth Hormone02:36:45 Most Underrated & Overrated PEDs02:38:23 Final Message: Legacy, Love, & Simplicity
This episode is dedicated to the memory of Dr. Al Yuzpe, a true pioneer in reproductive medicine.This episode (recorded in 2023) explores the evolution and future of IVF with leading Canadian reproductive endocrinologist Dr. Al Yuzpe. He reflects on 50 years of fertility advancements, including his role in developing Clomiphene and pioneering laparoscopic surgery in Canada.The conversation also dives into how reproductive medicine has transformed from its early beginnings into a groundbreaking field that has helped countless couples achieve parenthood. Dr. Yuzpe shares his passion for the field and discusses how emerging technologies, including artificial intelligence, are improving IVF outcomes and shaping the next generation of fertility care.Key Topics:Dr. Al Yuzpe's pioneering contributions to reproductive medicine, including the development of Clomiphene and early adoption of laparoscopic surgery in Canada. Key ovulation induction options (Clomiphene, Letrozole, FSH, HCG), including their effectiveness, differences, and potential side effects. Advances in IVF techniques, such as embryo selection (Day 3 vs. blastocyst), genetic screening, and egg freezing for fertility preservation. The growing role of integrative care—including acupuncture and whole-body preparation—in improving IVF outcomes. The future of fertility, highlighting artificial intelligence in evaluating eggs, sperm, and embryos, and ongoing innovations in embryo testing and lab technologies. Dr. Albert Yuzpe's Bio: Dr. Al Yuzpe is one of Canada's most distinguished reproductive endocrinologists, with over four decades of experience in infertility care and more than 30 years in IVF. He is co-founder and co-director of Olive Fertility Centre and previously founded Genesis Fertility Centre in Vancouver. Trained at Western University, where he later became a full professor and now holds the title of Emeritus Professor, his early research focused on fertility medications such as clomiphene and gonadotropins.He has received numerous national awards recognizing his contributions to reproductive medicine and women's health. Dr. Yuzpe is also widely known for pioneering the emergency contraceptive pill, known as the “Yuzpe method,” considered one of the most impactful Canadian health discoveries of the past century.
Send us Fan MailTrying to conceive can turn into a crash course in hormones overnight, and the medication list can feel like a different language. We slow it down and translate what fertility medications actually do in the body, why midwives still need to understand them even when we are not the prescribers, and how to support patients through the stress that often comes with IUI, IVF, and “why is this taking so long?” moments. We walk through the most common reason fertility care starts: ovulation problems. From anovulation and PCOS to the sometimes overlooked conversation about luteal phase length and early progesterone support, we talk about what might be happening on the HPO axis and what clinicians are trying to change with treatment. Then we break down the big names patients hear, including Clomid (clomiphene citrate) and letrozole (Femara), comparing how they work, what side effects to expect, and why practice has shifted toward letrozole for many people with PCOS and insulin-related hormonal patterns. We also dig into metformin and insulin resistance, because PCOS is not just “about weight” and fertility care should not be built on shame. Finally, we zoom out to the broader IVF medication lineup, including gonadotropin injections, GnRH agonist or antagonist protocols like Lupron, the hCG trigger shot, and progesterone support. We end with practical safety counseling, including multiples risk and ovarian hyperstimulation syndrome warning signs, plus clear guidance on when it is time to refer to reproductive endocrinology and infertility (REI). #FertilityMeds #PathToPregnancy #TTC #NavigatingFertility #PharmacologyForMidwives #ConceptionSupport #ReproductiveEndocrinology #EvidenceBasedMidwifery #InfertilityCare
Send us Fan MailTrying to conceive can turn into a crash course in hormones overnight, and the medication list can feel like a different language. We slow it down and translate what fertility medications actually do in the body, why midwives still need to understand them even when we are not the prescribers, and how to support patients through the stress that often comes with IUI, IVF, and “why is this taking so long?” moments. We walk through the most common reason fertility care starts: ovulation problems. From anovulation and PCOS to the sometimes overlooked conversation about luteal phase length and early progesterone support, we talk about what might be happening on the HPO axis and what clinicians are trying to change with treatment. Then we break down the big names patients hear, including Clomid (clomiphene citrate) and letrozole (Femara), comparing how they work, what side effects to expect, and why practice has shifted toward letrozole for many people with PCOS and insulin-related hormonal patterns. We also dig into metformin and insulin resistance, because PCOS is not just “about weight” and fertility care should not be built on shame. Finally, we zoom out to the broader IVF medication lineup, including gonadotropin injections, GnRH agonist or antagonist protocols like Lupron, the hCG trigger shot, and progesterone support. We end with practical safety counseling, including multiples risk and ovarian hyperstimulation syndrome warning signs, plus clear guidance on when it is time to refer to reproductive endocrinology and infertility (REI). #FertilityMeds #PathToPregnancy #TTC #NavigatingFertility #PharmacologyForMidwives #ConceptionSupport #ReproductiveEndocrinology #EvidenceBasedMidwifery #InfertilityCare
In today's episode, Vanessa breaks down five of the most popular diet protocols of the last 50 years — and compares them directly to Protein-Sparing Modified Fasting (PSMF) days.
Send us Fan MailIn this episode, Dr. Jaclyn Smeaton and DUTCH Founder Mark Newman discuss a case study published in Integrative Medicine: A Clinician's Journal in which Mark himself was the patient. The case covers the step-by-step hormonal and metabolic effects of using HCG to boost endogenous testosterone, revealing how increasing testosterone can cascade into elevated estrogen, impaired estrogen clearance, and strained methylation capacity. Their conversation also highlights: The benefits of combining serum testing and DUTCH testing to monitor dosing as well as metabolism, clearance, and methylation How methylation is affected by raising testosterone The value of tracking step-by-step supplementation plans with repeated testing The importance of baseline testing before beginning testosterone therapy An upcoming research publication that compares hormone testing methods for testosterone monitoring Read the DUTCH article and access the full IMCJ case report. Become a DUTCH Provider to see how the DUTCH Test can profoundly change the lives of your patients.
In this enlightening episode of Fertility in Focus, Dr. Christina Burns sits down with Dr. Kevin Jovanovic, MD, a leading expert in reproductive medicine and hormone optimization. Dr. Jovanovic shares his expertise on the intersection of fertility, hormones, and overall reproductive health, offering practical insights into improving egg quality, addressing hormonal imbalances, and supporting long-term reproductive wellness. This episode is perfect for anyone seeking to understand the science behind fertility and innovative strategies to enhance reproductive outcomes. In This Episode, You'll Learn:The role of testosterone in reproductive health Potential uses in fertility treatment The role of testosterone in overall hormonal health and well-being How HRT got a bad reputation Cosmetic gynecology options for women How low-level hCG may improve IVF outcomes The benefits of peptidesTimestamps:[00:01] Introduction to the podcast and today's topic [02:10] Meet Dr. Kevin Jovanovic and his background in OB-GYN and innovation [05:30] The history of hormone therapy and the impact of the 2002 WHI study [09:45] What are bioidentical hormones and how do they work? [14:20] Testosterone in women: Myths, benefits, and fertility impact [20:10] Signs of hormonal imbalance and testosterone deficiency [27:30] Birth control and its effects on fertility markers like AMH [35:00] Hormone therapy and its potential to improve ovarian function [42:15] Male fertility: Testosterone therapy and sperm production [48:30] Peptides explained: Benefits, uses, and safety considerations [55:40] Weight loss, metabolism, and fertility optimization strategies [01:05:10] Vaginal rejuvenation and integrative women's health treatments [01:12:00] Final thoughts and where to find Dr. Jovanovic Connect with Dr. Kevin Jovanovic: Website: Dr.Jovanovic.com Location: 935 Fifth Avenue, East 74th Street, Upper East Side, Manhattan, New York, NY Phone: (212) 249-6709About Dr. Christina Burns:Dr. Christina Burns is the founder and Doctor of Chinese Medicine at the Naturna Institute. Committed, compassionate, and highly skilled in multiple disciplines, Dr. Burns has been in practice since 2004. She empowers both women and men to achieve their optimal life and health goals through natural medicine practices, integrative nutrition, lifestyle management, and personalized mind-body programs. Dr. Burns holds advanced certifications in acupuncture, herbs, nutrition, life coaching, and yoga therapy. She is also the best-selling author of "The Ultimate Fertility Guidebook."Connect with Dr. Christina Burns:Website: https://www.christinaburns.com/Instagram: https://www.instagram.com/drchristinaburns/Order the Ultimate Fertility Guidebook: https://a.co/d/hq0nFOoJoin the Eating for Optimal Fertility Course: https://naturna.mn.co/Order Junk Juice: https://junkjuicemagic.com/Follow along with the Naturna Institute:Book an Appointment: https://naturna.janeapp.com/#/listInstagram: https://www.instagram.com/naturna_life/
Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors! Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization Resources: • Learn More About Dr. Houman's Work At: https://houmanmd.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Introduction 01:15 – Low Testosterone Epidemic 04:23 – Ejaculation & Testosterone 07:30 – Refractory Period & Aging 09:58 – Porn-Induced ED 11:09 – Cabergoline & Prolactin Management 12:42 – Oral Testosterone 13:24 – Testosterone Target Levels 16:46 – Supplements for Testosterone 18:46 – Anxiety-Based ED 26:23 – Penis Enhancement Options 27:37 – Shockwave Therapy 28:57 – Cialis for Longevity 29:56 – Fat & Filler Injections 34:50 – Pre-Sex Optimization 40:13 – Red Light Therapy 42:18 – Heat & Cold for Testosterone 43:35 – Underwear & Microplastics 44:58 – Testosterone & Fertility 49:15 – HCG & Preserving Fertility 52:00 – Testosterone Dosing Timing 53:22 – Creatine & Mitochondrial Health 55:20 – Overtraining Effects 56:24 – Peptides (PT-141) 59:08 – Optimal Diet for Fertility See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this conversation, Kiara Loucks shares her profound experiences during a health crisis that taught her the significance of community and support. She reflects on a moment of vulnerability when she had to rely on her husband for help and the intimate experience they shared before her surgery. Kiara emphasizes the importance of allowing others to be there for us in times of need and how such situations can strengthen relationships and foster personal growth. Outdoor retreats: heroutdorjourney.com Kiara on Instagram @kiara.loucks Takeaways Other people need to be in our lives sometimes. Facing health crises can reveal the strength of our relationships. Intimacy can be found in shared vulnerable moments. It’s okay to lean on others during tough times. Support from loved ones can be a source of strength. Crisis situations can deepen our connections with others. Prayer and faith can provide comfort in uncertainty. Allowing help can be a sign of strength, not weakness. People often want to step up and help when we need it. Vulnerability can lead to personal growth and understanding. Disclaimer: Links may contain affiliate links, which means we may get paid a commission at no additional cost to you if you purchase through this page. Read our full disclosure here. Watch on YouTube Show Transcript Cheryl McColgan (00:00)Hey everyone, I’m Cheryl McColgan, founder of Carol Nourish Grow, and today I’m joined by Kiara Lux. Kiara and I met this year when I competed in the fit model competition in Kentucky and she had the same coach that I did and ended up doing the same show. And I just immediately loved this woman. So what I learned. about her journey and her health stuff I had to have her on. anyway, Kiara, welcome. If you could ⁓ just tell everyone a little bit about who you are and then we’ll get into some of your health journey. Because I think it’s really interesting and I think there’s a lot of things there that will help a lot of people. Kiara Loucks (00:35)Absolutely. First off, thank you so much for having me. I’m so honored to be here. My take on our meeting is very similar. I just fell in love with you from the second you texted me asking if I wanted sourdough. We had never met. You brought me sourdough. I was like, I don’t know her, but I love her. So yeah, I’ve had quite a wild journey. Health and fitness have been at the center of my journey. Cheryl McColgan (00:43)you Kiara Loucks (00:57)Really since I was young, I’ve been an athlete my whole life in different sports that have taken me all over the world and brought wonderful people like yourself into my life. Outside of professional athletics, I work in tech on my, like my nine to five, I work on Wall Street in paid media. And then I actually am now running an organization on the other side of that. with all of the spare time called her outdoor journey, which is really focused on bridging the gap for women and families in the back country. So whether it’s survival, holistic wellness, it’s really this concept of community and education to get women and families outside, which is now actually evolving into co-ed opportunities. So in a very, very high level nutshell, that is me. My fitness journey was, I’m sure we’ll dive into it, but. I don’t think you knew this, but I’m actually over 100 pounds down from my heaviest, so that was 11 years ago. Just, think, like most people, kind of gave up and had always wanted to compete, but it was a pipe dream that never had any real legs to it until it did. So really excited to dive in with you, and I’m just excited to be able to chat with you. You’re one of my favorite people. Cheryl McColgan (02:04)I know it’s been I wanted to catch up for so long. And we just like you’ve been traveling so much and doing really exciting work with the project that you mentioned, and we’ll get into that. But before we go into all that, and we go into the weight loss thing, because that is definitely a subject that people are on this podcast are interested in. But I have to have you tell people, you to kind of just glossed over that whole professional athlete thing, tell people what you what your sport is, because I think it’s so wild. Kiara Loucks (02:07)I know. Yeah, so I’m kind of in this purgatory season right now, so not actually professionally competing in anything, but I’ve been a professional rower. I’ve been a professional bobsledder for the US and Canada. I’ve been a bodybuilder, Olympic weightlifter. We’ve been all over the map. Yeah, and I’m kind of getting back into the endurance side of things right now. I’m not done with bodybuilding or Cheryl McColgan (02:43)That’s the one. Kiara Loucks (02:54)Bodybuilding isn’t done with me yet, but we’re on a little hiatus. As you know, it kind of takes over your whole life. And I’ve lived a season for the last decade where sports is my whole life. So I’m kind of just turning my brain on for a little bit and creating and doing other things. Cheryl McColgan (03:08)Yeah, and I think that’s, it’s an interesting mindset being an athlete for most of your whole life. So you said though, at some point you kind of gave up, can you share a little bit more about that? Was there an injury? Was there something that happened in your life where things just shifted for you? And how did that go? And then how did you get back to where you are now? Kiara Loucks (03:19)Thank you. Yeah, great question. You seem like the type that’s okay to go kind of deep and heavy off the rip because that’s just life. So I had actually signed a scholarship agreement with UC Santa Barbara to play softball ⁓ once I graduated high school. And my senior year in high school, I both broke my back quite literally to vertebrae on my back in a terrible sledding accident. And then I also endured a sexual assault. So I was raped my senior year in high school. And those two, I think combined, just put me in a place I didn’t know how to cope. And so I learned growing up that food is comfort. And when we hurt, we self-soothe. And I didn’t have the tools in my toolkit to do that in a healthy way. So I started partying a lot, started eating a lot. And honestly, by the grace of God, I walked onto campus to try to rush for a sorority. I missed. I missed rush, but I had walked by the rowing recruiter tent. And some young gal shouted at me. She was like, Hey, you have really big legs. Would you want to row? And I was like, simultaneously so offended and so flattered. I was like, let’s try it. And that opened this new avenue we’ve been on for the last decade. But prior to that, I just like, like I said, I had given up and food was really my reprieve. from life. Cheryl McColgan (04:47)And I think a lot of people will be able to relate to that. And I’m so sorry that you had to go through that experience. Although often some of the great tragedies in our life really end up shaping who we are. And I think that that is definitely one of the reasons that’s contributed to you, you know, being so successful and being able to overcome all that. So, but anyway, definitely a heavy subject and thank you for being willing to share that with people. So after all that happened, you wrote in college and then let’s fast forward to like just Kiara Loucks (04:59)Delicious. Agreed. Mm-hmm. Cheryl McColgan (05:16)before we met because you had some pretty crazy health things and things happening in your life right before you decided to compete. So I’d love it if you’d kind of share that journey. Kiara Loucks (05:27)Yeah, so like I alluded to bodybuilding was a dream of mine for the last 12 years like I saw someone do it and thought it was the coolest thing and Never thought it was a realistic opportunity for me and then fast-forward lots of things changed and Decided actually a year ago that I was gonna get into bodybuilding and got into it locally it went swimmingly like I just Found a lot of success very quickly But in an extremely unhealthy way working with a coach which bodybuilding is wrought with coaches who went pro and then think that they have the license to dictate someone else’s health. So went down that rabbit hole came out of we did four shows back to back to back to back. We blitzed last fall and did really well coming into the offseason after my last show in November of last year. Cheryl McColgan (06:12)a lot. Kiara Loucks (06:20)I was following my reverse diet to a T and was putting on weight extremely rapidly and Not only was it a mental Battle it was also physically feeling out of control of my body and on top of that I started bleeding Like non-stop started presenting pregnancy symptoms had no idea what was happening in my body had just kind of taken on its own life And so it was controlling all that I could At first they thought I had cervical cancer and so we went kind of through some rounds of testing for that and then coming back in January This was like a three-month saga coming back in January found out I was pregnant and Then they thought I was having a miscarriage because I was bleeding the entire time. So I was extremely anemic I was just exhausted. I couldn’t really do much and I Would not give up training like that was the only thing I really had was just training and trying to be present for the holidays and so After they thought I had a miscarriage, my HCG levels, which are the hormones present when you are pregnant, were actually going back up. And so it was end of January, or this year, that they found out I had an egg-topic pregnancy growing in my left ovary. And we were early enough that they had attempted to treat it with chemotherapy. So methotrexate is a chemotherapy procedure that they typically will try. before they go to surgery as an intervention in order to try to get the cells to kind of reabsorb into the body. It stops everything from turning over, which my goober brain decided to still train, still try to move through all of it, even if that was just walking on the treadmill for most days. So was extremely humbling. But through that, I had one round of chemo, which was just hell for lack of a better term. and then it ended up rupturing anyway. So by rupture, I mean I was internally bleeding, had come up with a fever in the midst of all of the chemo symptoms. So for those out there who are not privy to what that looks like, your body feels like it’s on fire. I couldn’t smile, I couldn’t chew, I couldn’t laugh, I couldn’t cry. Everything from my head to my neck to my back would just seize. And so in the midst of that, I popped a fever. We went in and as we were walking into the ER, I was rupturing. And so they opened the OR middle of the night and had a surgical intervention for that. And then me being me, I needed something on the calendar. Maybe not the best way to cope, we’re learning, but I’ve always been someone that when I have something to shoot for, the in-between between here and there doesn’t really matter. We have a goal, we’re working towards something, we’re progressing, we’re… Controlling our environment for lack of better term as well. So put a show on the calendar and decided to find a new coach because like I mentioned, my previous coach was not health conscious at all. And so I found Adam who’s just a godsend and was able to actually reverse some of my endometriosis symptoms, certain things through protocol with supplementation and food. It was a miracle and we started prep while I still had chemo in my system. We were like hitting the ground running, let’s go. And that was beginning of February, March timeframe. And then we walked into the show that you and I met at, which was in Louisville. went well, not as well as I’d hoped, but it’s okay. It was still a blast and I met you. And then we did two shows right after that in Las Vegas and then in Chattanooga, Tennessee. So. Cheryl McColgan (09:57)and she’s leaving out that she won one of those shows, which I was not surprised because seeing you in person and now knowing everything that you went through leading up to that, mean, the amount of muscle that you have. Kiara Loucks (09:59)We did bring home Miss Nevada this year. I was very excited about that. Cheryl McColgan (10:17)is a testament to, I think something that people kind of lose sight of sometimes is that your muscle is a metabolic sink for a lot of things that it helps control your blood sugar. helps. It helps you survive times like what you went through. And I’m convinced that’s one reason my dad did so well with his cancer treatments over the years is because he was always really muscular. He was like Jack Lillane, basically my dad, he was like into that way before anyone else. So he’s never like huge, but he always was very concerned. He always lifted. And so I would say, you know, do you feel like both your mentality as someone that was into fitness helped you as well as the fact that you were already in such good shape to start with? Because I think you just, the outcomes are so much better if you have some muscle. Kiara Loucks (10:59)Yeah. Absolutely. Yeah, I think twofold. The physical side of it, there’s research to support that muscle mass is an indicator of longevity and it’s also the best way to push off atrophy in the body as we age. So knowing that no matter what sport you’re doing, having lean muscle mass is going to always be a benefit. That’s kind of the first part and it allows your body to bounce back really quickly. Like you’re a lot more resistant to… whatever life throws at you, whether it’s disease or acute injury. And so that’s kind of the first side. And then the second side is the mental side. So when I, know, as someone who’s been an athlete my whole life was told I can’t do anything, let alone like I can’t even walk on a treadmill. Mentally, I just crumbled. But then you realize and you’ll get this too, no matter what sport you do, or just lifting in general for people that just go to the gym to stay healthy. It’s not easy and it hurts. Like you are training your body to deal with things that hurt knowing full well that you’re going to be better for it. And I think that was the privilege walking into my health situation last year was that mentality that I’m going to make it through this. It sucks and it really hurts. It’s not going to last forever. I guarantee it. And I’m going to be better on the other side of it, whether that’s mentally, emotionally, spiritually, or all of the above. We’re going to be OK. Cheryl McColgan (12:26)And how so how did you get from the point? Where I mean, to me, like putting something like that on the books is just. unbelievable. And then to see the shape that you showed up in, I mean, it was just unbelievable. So can you talk about your mental state during that time a little bit? Because I think there’s, you know, whether people are an athlete or not, I think there’s always something to be learned with mindset. And I think the more that you can share about maybe that part of that and how you, you know, seemingly made it through to the other side. I mean, nobody’s saying everything’s perfect all the time, but you still move through Kiara Loucks (12:39)Thank you. Thank you. Cheryl McColgan (13:04)life, you created these amazing goals, you are still working all this time. Talk a little bit about your mindset and how you, how do you overcome that hurdle like once you were on the chemo and doing all this really crazy health stuff. Kiara Loucks (13:17)That is such a good question. Yeah, I think when life really kicks her teeth in, it’s usually there to teach us something. And I hate to be the person that’s like, it always happens for a reason, because it doesn’t always. But being able to take a really poopy situation and make meaning of it and find that meaning while you’re walking through it is really the best way to endure it. So for me, I’ve always been an incredibly independent woman. I don’t need anyone. I don’t need help. and I never ask for help. And so my husband had just gotten out of the army. So we’re actually one year free as of two days ago on Veterans Day. And when he came back, we actually had a really hard time because I had kind of established this life where he was more of an accessory than a need. And I didn’t have an issue with that. In fact, when he got home, I reminded him that I didn’t need him. I want him. And know, like all of these pieces that I think the intention was pure, but this chapter, the health chapter we’re talking about really taught me that other people need to be needed in our lives sometimes. And allowing space for that, I didn’t have an option. So there was literally a week where my husband had to help me go to the bathroom. And I still remember when we were in the OR. We didn’t know we were going to go into surgery when we went into the ER and they basically threw a pack of ammonia wipes at us as they’re opening the OR because it was like you can die relatively quickly from internal bleeding. And so they threw this bag of ammonia wipes at us and it was such an intimate moment where they were like, all right, wipe yourself down like we’re going to go open the OR. We’ll be back. And my husband and I both took a wipe and we just started cleaning things off. like prepping for surgery. And I’m standing there like, I know you’re not a believer, but I’m just gonna pray over us and the situation and where we’re going. And that whole evolution taught me it’s okay to need other people. And people in our lives are often eager for those situations where they can step up for us when we’re the ones typically stepping up for everyone else. So mentally, it allowed a lot of intimate. relationships to just flourish in my life, both my husband, my family, who all stepped in for me. And through that, it was like this mental battle to be okay not being okay on a daily basis. And then as we put the show on the calendar, things are kind of turning around, things are getting better. Then it became this super cool ethos of Everyone’s gonna hear the high school musical theme. We’re all in it together. Like it was cool that we were all in the trenches together like great We all watched movies together. Everyone helped me. It was fantastic But now we’re on the come-up together and realizing how rich that come-up was with everyone in tow And so my husband was there in Louisville. He was there in Chattanooga for Nationals Like he’s texting me constantly when I’m at shows and he’s not there Cheryl McColgan (15:58)you Kiara Loucks (16:22)It brought us so much closer together and it made me realize that win, lose or draw, I’m a better person for being in this with the people that I love building something that’s inspirational for other people. Like the number of messages I had of people who, from people who had watched the whole health journey into the prep, into the shows, into doing very well in the shows, who reached out and said like, holy shit, I’m going to get off the couch and I’m going to do this because if you can do this, like I can do that. And so it’s realizing mentally, we don’t live for ourselves. Like the fullest life we can possibly aim to live is that for others. And bodybuilding is an incredibly selfish sport, but this whole evolution turned it around into this is for my family, this is with my family, this is for other people. And I will be extremely transparent about all of the highs and the lows and everything in between. So I don’t know if that answered your question, but yeah, it was a really cool turning point for me that has. completely transcended bodybuilding into my career, into my hobbies, into my passion projects on the side. So it’s been really cool. Cheryl McColgan (17:28)Yeah, and it’s been it’s been so fun to watch as people on the outside, like you said, you had so many people rooting for you and just following along with your journey. And, you know, I guess part of our time together was like we were at the show doing this and we were in separate divisions. And so we kind of had to stick to, I guess, you know, I don’t want to say surface level conversations, but we didn’t get a chance to really dive deep into some of this stuff. So it wasn’t until later afterwards where I was watching, you know, some of your Instagram stories and Kiara Loucks (17:42)Yes. Mm-hmm. Okay. Cheryl McColgan (17:58)of the comments that people were making about your health journey and all this stuff that I really was able to see, you know, just how much you would come through. so hearing this today kind of like puts all the pieces together and just makes the whole thing even just more amazing. And I think it’s really exciting now what you’re kind of turning that into because I have a feeling that all of this And you know, just recovering after a show people that haven’t done it. It’s, know, bodybuilding is not a healthy thing. Let’s be real lifting weights is healthy, but bodybuilding is a very extreme sport. You’re getting to an extreme level of leanness, which especially for women is really hard, like on your hormones on your body, everything. And, you know, I’ve certainly experienced that. I don’t know, aftermath, for lack of a better word. ⁓ Kiara Loucks (18:27)No. Mm-hmm. Yep. Yep. Cheryl McColgan (18:49)And it’s just a very interesting mental challenge afterwards as well as physical. And ⁓ so it wasn’t surprising to me that I saw after your show, you kind of turned to ⁓ this retreat that you ended up going on. so now I would love it if you’d share about that. Like what made you become aware of that? And is my sense right that you kind of just needed some like recharge alone time? I’d to hear just all about that, how that happened. Kiara Loucks (18:54)⁓ Yeah. Mm-hmm. Yeah. Yeah, I love this. It’s like the most exciting thing in my life right now. So 100 % you’re correct. Once the show season was over, I just realized how much of my time had been spent in the gym, working, and then being a wife, being in the family. Like it’s just every day just trying to go. And one of my favorite things is spending time outside. Like I firmly believe that it is the closest place to the divine. It makes me happy. It gives me clarity. Like it is my favorite place to be. I live in Colorado. So I realized like a year went by that I hadn’t gone just to play outside with my dog. Like, okay, like I just need to get outside more. And I was feeling this void, which did you feel after the show too? It’s like this depression a little bit. Cheryl McColgan (19:45)Love it. a little bit. It’s kind of a, you know, I wish I would have done a better job documenting some of that stuff I kept meaning to, because it is just kind of a wild thing. But it never I guess, for part of it for me is because Kiara Loucks (20:11)Mm-hmm. Cheryl McColgan (20:16)I always knew that I would, you know, I’m still working, going to the gym five days a week and still just really trying to build my lean muscle for the purposes we were talking about, just making sure that I stay as healthy as possible for as long as possible and that I can lift myself off the toilet when I’m 80 years old and things like that, you know, if I’m lucky enough to make it to that age. ⁓ Kiara Loucks (20:30)Mm-hmm. Yeah. Yep. Exactly. Cheryl McColgan (20:39)So I guess in the back of my mind, it was like, well, this was an interesting process and stuff, but I was anxious to kind of get back to quote unquote normal life. Like what you’re talking about, like more time to spend time outdoors and more time to enjoy food and drinks with friends and not have to be so focused on every single bite you’re putting in your mouth. I don’t know, somehow I kind of, feel like I distracted myself from a little bit of that, but I… Kiara Loucks (20:48)normal yeah Exactly. Cheryl McColgan (21:06)I’ve read a lot of and heard a lot of other people’s stories that talk about that because this almost like well you you had these goals, the goal you got there basically. And then what you kind of go off the cliff, right? Yeah, I don’t know. I avoided that a little bit. I don’t know that sure how Kiara Loucks (21:15)Yeah, exactly. Yeah, so perfect. You know, I’m thrilled for you. did not. I just, I don’t know. Like I think if I had a body that could sustain it, which I don’t think anybody’s meant for it, I would compete all year long every year. Like I just love it so much. But when we finished nationals in Chattanooga, I just knew my body was asking for a break. Like there were just several signs that I needed to pump the, pump the breaks and chill. And so coming out of that, I realized I needed to be outside more and I just felt this void like. this one thing I’d been working for and felt meaning in, all these people invested in my story, it just was suddenly gone. And so I’m like, okay, I just need to go outside. And I had a dear girlfriend of mine actually come out and we went up to a cabin in the mountains and we were chatting and it like, I just don’t know what I’m chasing after. Like I always have something I’m chasing after and I feel like I’m missing it. And she was like, well, Kiara, you’ve been chasing outside. Like since you finished competing, all you’ve done is chase the mountains. And I’m like, well, no, no, no, like that’s just a medium. That’s a catalyst for me to find clarity. That’s not what I’m chasing. Yeah, that’s ridiculous. And sure enough, it is what I was chasing. And for the last several years, I’ve had on my vision board wanting to start a business to allow space and build a community for women to get out into the back country together. Because like all of the same things that you and I probably took away from bodybuilding, the confidence, the discipline, the community aspect, if you’re fortunate to have that, like Those are all things that I’ve found historically in the outdoors, but I think the value of the outdoors far outlasts and has much deeper lengths to it than bodybuilding. And so it’s been on my vision board for years to start a business that I can just take women outdoors and on these retreats and do cool things. And it was just another pipe dream, right? But God bless vision boards and always coming back to like ourselves and where we find meaning and purpose. And so just by happenstance, this opportunity dropped into my lap in August. So my last show of the year was middle of June, went outside a bunch, kind of just got my head screwed on a little bit for the rest of June and July. And then this opportunity dropped in my lap to go to Montana with a group called Her Outdoor Journey in August. And it was gonna be their summit, which means they were doing everything from Butchery to survival to fieldcraft to foraging to defensive shooting to Glassing which is basically understanding how to scope the side of a hill and look for animals They were doing all of this in one event. I was like alright cool I will help you guys out in trade just to go check this out because it seems kind of rad and I on a whim didn’t know anyone got in the car drove up to Montana like 12 hours And I show up and this week completely changed my life. mean, I’ve never been around a group of 20 plus women and there’s no drama, no clicks, people wanting to help, people wanting to serve, everyone having a blast. Like, and not only that, it was the skill sets that we were handed, like the education and the content. was like, I need more of this and I need to share this with as many people as I can. Like, how can I get more in the weeds on this? So I sat down with Courtney Pridi, who is the founder of her outdoor journey. And we just kind of started dreaming up how we could work together and she needed me. I needed her. Like it was this extremely serendipitous, miraculous meeting of two people who desperately needed each other. And her and I since then have walked hand in hand, just blowing the lid off of this thing. So we have like over 15 events next year, all across the continental US, Alaska and Hawaii. We’re also looking at Canada. But our mission really is to teach and empower women and get them outside. And it’s like this beautiful thing that happens when you’re learning and you’re vulnerable, when you’re outside, like all of these perfect elements that bring out the most beautiful side of people. And that’s the part that I love is nurturing these women, these people, these families, seeing how we can impact as many women and families as we can. So. Yeah, long story short, it has been the coolest thing I have found and I also fell in love with butchery out of that. So have kind of been on this whirlwind of working with feedlots and local ranchers and processing plants, understanding truly what is it that we’re eating. So going back to health and wellness, we just talked about bodybuilding is not a healthy sport. And so when you’re given a certain set macros for the day, you’ll eat trash as long as it fills those macros and you’re enjoying it. When Cheryl McColgan (26:02)Thank Kiara Loucks (26:04)Much like you, I got into this because I fell in love with taking care of myself. And so I had completely gone off path. And when I found this, it was like, ⁓ I can literally make an entire meal for me and my family off of literally just what exists out here in the back country. Understanding the seasonings, the foods that we are given naturally growing in the mountains or wherever. What Google reactions. ⁓ she is. But yeah, ⁓ so it’s just Cheryl McColgan (26:31)you Kiara Loucks (26:33)this really cool journey that’s now evolved into the butchery side of things and long tail like I would love one day to open my own high end butcher shop and do high end steak dinners for people that they get to pick right out of the case supporting local agriculture, which is a dying breed in our country right now. So bringing awareness to those things, bringing people along for the ride. I have no idea what we’re going to do with all of this, but I’m just so happy. Like I’m just right where I feel like I need to be. Cheryl McColgan (27:02)Yeah, watching some of your stories when you were on that retreat, I felt the same way. I was just so happy for you because I could just tell you were enjoying it so much and you’re in your element. And it did not surprise me afterwards that you’re like, I’m going to be a butcher. I mean, you’re crazy. I’ll get on to something. I’m just like, Oh, well, this is now this is my thing, you know, which is amazing. So so people are hearing this and they’re like, Okay, that sounds really cool. I would love to, you know, spend some time with other women out Kiara Loucks (27:10)Hmm. No! Yeah, exactly. Okay. Cheryl McColgan (27:31)doors, do all the things. And also though, I can see how maybe some people like there probably will be some people to be like, okay, I like a lot of that, but I’m not into the hunting or I like a lot of that, but I don’t know that I want to chop up a deer and skin a deer on this retreat. Tell us how that works. Kiara Loucks (27:40)What? yeah, very fair. Not expected, not expected at all. So we actually offer a whole host of opportunities for people to get on trips with us. One of the events I’m looking forward to the most is actually an adventure retreat up in Alaska. So we are literally gonna go jet ski in the glacier, ride horses, ATV, spa day. Like it is an adventure retreat. There is no hunting, there are no guns. There’s no butchery. There’s no nothing that should really kind of raise flags for some people. Knowing that, everyone has different thresholds. So if you come on any of our trips and you’re like, this part is not for me. So for example, the event that I was just talking about back in August, the defensive shooting, we had women that didn’t feel comfortable being on a range with other women who had never shot a gun. Great. They went out and had their own like they went for a hike. They read their books. They went and hung out. There’s so much freedom and liberty to do whatever you’re comfortable with. Our mission is to serve you and make sure you’re walking away with what you intended to get out of an event. So whether that’s rest and recovery, a little adventure, learning skills or trades, we do it all. And there’s never any judgment when you decide something isn’t for you. Cheryl McColgan (29:01)can you share the website and where they can find out information about the trips and do you know off the top of your head like when the next one is? Because this episode will come out fairly soon here. Kiara Loucks (29:09)Yes, absolutely. Yeah, so our next one coming up is actually our first winter retreat in Yellowstone. So you can find out more at heroutdorjourney.com or on Instagram at heroutdorjourney. And we’re actually just launching all of our events for next year. So take a look. We actually have everything from, like I said, the adventure retreats to archery, long range shooting, you name it. We got it. And we also have payment plans. So knowing that some of these are maybe a little bit more expensive, we do have payment plans and we also have gift cards. So knowing the holidays are coming up, if you want to gift some special lady in your life the time of her life and change her world forever, we are your people. So give us a shout. Cheryl McColgan (29:52)Awesome. And on top of that, where can people connect with you personally and kind of follow along with your journey? ⁓ You post somewhat frequently Instagram, but I don’t know if you have any other socials that you want to share. Kiara Loucks (30:03)Yeah, yeah, no, Instagram is the best. As I’m kind of defining this new chapter of my life, I’ve tried to be a little more conscientious about what I’m posting and how I’m presenting to the world. So we’re gonna get back in the saddle here pretty soon with more consistent posts and all sorts of exciting stuff going on in the world. But yeah, follow along at at Chiara.Lowx. Yeah, at Chiara.Lowx. My brain is halfway here. Yeah, there you go. Cheryl McColgan (30:25)One, I’ll have it in the show notes as well if for some reason you can’t find her. Well, Kiara, it’s been so wonderful catching up with you again today and ⁓ sharing more of your journey that I was not aware of. And I’m really excited for everything that’s going to happen next. And I will be following along to see what amazing things you do from here. Kiara Loucks (30:43)thank you. And thank you again for having me on. You’re just one of my favorite people, even though we haven’t spent a ton of time together, obviously. But sourdough, you won my heart forever. So thank you. Cheryl McColgan (30:53)It’s my love language. All right, take care and we’ll see you again next time. Kiara Loucks (30:55)I’m here for it. Sounds good. Thank you.
On today's episode of The Wholesome Fertility Podcast, I'm joined by Jay Campbell (@jaycampbell333), health optimization expert, author, and founder of BioLongevity Labs, to explore the powerful intersection of peptides, metabolic health, and fertility. Jay shares how therapeutic peptides like HCG, HMG, and GLP compounds can support male fertility, insulin resistance, and metabolic balance when used correctly. We discuss the rise of GLP-1 medications, why microdosing matters, and how inflammation and visceral fat are major contributors to declining fertility rates. Beyond the physical, we also dive into mindset, consciousness, and how belief systems impact healing and reproductive outcomes. This conversation bridges cutting-edge science with empowered awareness, and offers a new perspective on fertility optimization in the modern world. Key Takeaways: Therapeutic peptides such as HCG and HMG can help stimulate FSH and LH to support male fertility. Chronic inflammation and visceral fat are major drivers of insulin resistance and declining fertility. GLP-1 medications can be helpful tools when microdosed and combined with proper lifestyle habits. Insulin-controlled living and metabolic flexibility are foundational for hormonal balance. Sustainable fat loss requires resistance training, adequate protein intake, and hormonal optimization. Environmental toxins and endocrine disruptors contribute to the global fertility decline. Mindset and consciousness play a significant role in healing, longevity, and reproductive success. Guest Bio: Jay Campbell (@jaycampbell333) is a global authority in hormone optimization, peptides, and human longevity, a five-time international bestselling author, and the co-founder of BioLongevity Labs—often called "the Amazon for biohackers." For more than two decades, he has led the field of metabolic health and anti-aging science, helping millions enhance vitality, repair their biology, and take control of their health. Known for cutting through misinformation, Jay translates complex biomedical research into practical, real-world strategies with integrity and no-BS clarity, blending cutting-edge science with a consciousness-driven approach that elevates biology, mindset, identity, and purpose. He is also the author of the upcoming book Metabolic Awakening, which addresses the global misuse of GLP drugs and introduces the first responsible, science-aligned framework for microdosing GLP peptides to support long-term metabolic repair rather than temporary weight loss. Connect with Jay: Follow him on InstagramVisit his website Disclaimer: The information shared on this podcast is for educational and informational purposes only and is not intended as medical advice. Please consult with your healthcare provider before making any changes to your health or fertility care. Ready to discover what your body needs most on your fertility journey? Take the personalized quiz inside The Wholesome Fertility Journey and get tailored resources to meet you exactly where you are: https://www.michelleoravitz.com/the-wholesome-fertility-journey For more about my work and offerings, visit: www.michelleoravitz.com Curious about ancient wisdom for fertility? Grab my book The Way of Fertility: https://www.michelleoravitz.com/thewayoffertility Join the Wholesome Fertility Facebook Group for free resources & community support: https://www.facebook.com/groups/2149554308396504/ Connect with me on social: Instagram: @thewholesomelotusfertilityFacebook: The Wholesome Lotus
Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. In this episode, the Fertility Docs walk listeners through what typically happens after a positive pregnancy test following IVF. The doctors explain how early pregnancy is monitored, beginning with the first pregnancy blood test about two weeks after embryo transfer and continuing with repeat hormone testing every few days to ensure appropriate rises. They discuss what doctors look for on early ultrasounds, why some patients need closer monitoring, and how different outcomes such as viable pregnancies, biochemical pregnancies, ectopic pregnancies, or abnormal intrauterine pregnancies are identified and managed. The episode also covers when patients go back to their OB/GYN once a pregnancy is progressing normally. The doctors answered many common questions patients search for after seeing that first positive test. Questions such as what happens after a positive IVF pregnancy test and how often pregnancy hormone levels are checked come up frequently. They explain how much hCG should rise in early pregnancy and what it means if it does not increase appropriately. The episode addresses when the first ultrasound is done after IVF and what doctors are hoping to see at five to six weeks of pregnancy. They discuss what an ectopic pregnancy is, how it is diagnosed, and why it can be difficult to distinguish early on from an abnormal intrauterine pregnancy. Other common concerns include what a biochemical pregnancy means, how abnormal pregnancies are treated, and when expectant management may be appropriate. Finally, the hosts review how long fertility clinics typically follow patients during early pregnancy and when care is transferred to an obstetrician.
Welcome to the emDOCs.net podcast! Join us as we review our high-yield posts from our website emDOCs.net.Today on the emDOCs cast with Brit Long (@long_brit), we cover myths and misconceptions in ectopic pregnancy testing including urine and serum β-hCG and ultrasound. Please see Part 1 for myths on risk factors, history, and exam. To continue to make this a worthwhile podcast for you to listen to, we appreciate any feedback and comments you may have for us. Please let us know!Subscribe to the podcast on one of the many platforms below:Apple iTunesSpotifyGoogle Play
No episódio de hoje do Check-up Semanal, o Dr. Ronaldo Gismondi, editor-chefe médico do Portal Afya e do Whitebook, comenta os principais destaques recentes em Ginecologia e Obstetrícia, com foco em terapia hormonal na menopausa, decisões no segundo estágio do parto, analgesia para inserção de DIU, impacto dos miomas intramurais na FIV e abordagem diagnóstica do hCG positivo.Leia na íntegra os artigos mencionados hoje:Atualização Cochrane 2025 sobre terapia de reposição hormonal na pós-menopausaParto vaginal operatório X cesárea no período expulsivo: qual a opção mais seguraEficácia e segurança de anestésicos tópicos na inserção de DIUMiomectomia em miomas intramurais antes da FIV: o que dizem as evidências atuais?Novo Consenso Clínico do ACOG sobre avaliação do hCG
The guys discuss many things including the HCG diet with The Protein BrosFollow The Protein Bros: ► https://www.youtube.com/@UCUQOvzxP8I_Ku0vpEIqDYpg ► https://www.instagram.com/proteinbrospodcast/For High-quality labs:► http://sagebio.com/For information on the Gillett Health clinic, lab panels, and health coaching:► https://GillettHealth.comFollow Gillett Health for more content from James and Kyle► https://instagram.com/gilletthealth► https://www.tiktok.com/@gilletthealth► https://twitter.com/gilletthealth► https://www.facebook.com/gilletthealthFollow Kyle Gillett, MD► https://instagram.com/kylegillettmdFollow James O'Hara, NP► https://Instagram.com/jamesoharanpFor 10% off Gorilla Mind products, including SIGMA: Use code “GH10”► https://gorillamind.com/For discounts on high-quality supplements►https://www.thorne.com/u/GillettHealth#peptides #diet #proteinAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Join My Private Group: https://theaxioncollective.manus.space/Email List: https://huntershealthhacks.beehiiv.com/Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this episode I'm breaking down the five most common “fertility adjuncts” men use alongside TRT: enclomiphene, hCG, hMG, kisspeptin, and gonadorelin.Taylor and I are in the middle of our own family-planning season, so I've been going deep on what actually preserves fertility on testosterone, what helps you actively move sperm parameters when you're trying to conceive, and what's mostly just a cheaper workaround that gets overhyped.We'll start with the core problem: TRT suppresses LH and FSH, which over time can reduce intratesticular testosterone, sperm output, and testicular fullness. Then I'll compare each option in plain English—how it works, who it's best for, and where it falls short.You'll hear why I view hCG as the backbone for most men, when hMG becomes the “needle mover” for conception, where enclomiphene fits (and why I don't love it as a decades-long solution), why kisspeptin is more of a libido layer than a true fertility replacement, and why gonadorelin is mainly a budget play for guys who are done having kids.Big takeaway: TRT doesn't automatically mean sacrificing fertility—if you use the right strategy.
Send us a textFor years, fertility medications were one of the biggest and least controllable costs in IVF—sometimes costing more than the procedure itself. Then, almost overnight, prices dropped by nearly 50%.In this episode, Dr. Mark Amols explains what actually caused this dramatic shift, how government policy and pharmaceutical competition reshaped pricing, and why this change is already affecting IVF protocols. He breaks down what lower gonadotropin costs mean for patients, how this impacts the use of Menopur, and why low-dose hCG is now becoming a more cost-effective alternative for LH activity in many cycles.If you're preparing for IVF, freezing eggs, or struggling with medication costs, this episode will help you understand how these changes can affect your treatment, your budget, and your options.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.
In this JCO Precision Oncology Article Insights episode, host Dr. Jiasen He summaries the article, "Longitudinal Evaluation of Circulating Tumor DNA as a Prognostic Biomarker to Detect Molecular Residual Disease in Germ Cell Tumors," by Hassoun et al. TRANSCRIPT Jiasen He: Hello, and welcome to the JCO Precision Oncology Article Insights. I'm your host, Jiasen He, and today, we'll be discussing the JCO Precision Oncology article, "Longitudinal Evaluation of Circulating Tumor DNA as a Prognostic Biomarker to Detect Molecular Residual Disease in Germ Cell Tumors," by Dr. Rebecca Hassoun and colleagues. Traditionally, treatment response for solid tumors has relied on imaging, which focuses on visible anatomic changes in the tumor. However, imaging does not always reflect molecular or cellular changes and cannot detect microscopic disease, which is clinically important and often linked to relapse. Liquid biopsy, on the other hand, is minimally invasive and can be used for cancer monitoring by analyzing circulating biomarkers in biofluids such as blood. One type of liquid biopsy is circulating tumor DNA, or ctDNA, which measures small fragments of DNA released by tumor cells into the bloodstream. ctDNA can allow precise monitoring of tumor-specific mutations and be a powerful tool for assessing treatment responses. ctDNA has already been applied in clinical settings for cancers such as non-small cell lung cancer and breast cancer, etcetera. However, there is still limited data on the use of ctDNA for germ cell tumors. Germ cell tumors are the most common malignancy affecting men aged 15 to 35 years. Accurate risk stratification and disease monitoring is key to risk-adapted therapy, maximizing the chance of cure while minimizing side effects. One unique tool we use currently for diagnosis, staging, and monitoring is serum tumor markers, such as AFP, beta-hCG, and LDH. However, these markers have limitations, including false elevation in certain clinical scenarios, and studies have shown that they can be normal in up to 40 percent of patients with germ cell tumor. This creates an unmet need for other sensitive and specific biomarkers to improve patient care. In this paper, the authors investigated the use of ctDNA in a cohort of patients with germ cell tumor at various disease time points. They compared ctDNA results with traditional serum tumor markers to evaluate whether ctDNA can predict relapse and survival outcomes. This multi-institutional retrospective study included patients with stage I, II, and III germ cell tumors, primarily testicular cancer, who had at least one ctDNA test result. ctDNA was evaluated longitudinally at different time points, including pre-orchiectomy, during the molecular residual disease, or MRD, window, defined as 1 to 12 weeks post-orchiectomy but before primary therapy, and during the surveillance window, defined as more than 12 weeks post-orchiectomy or follow retroperitoneal lymph node dissection or post-chemotherapy. ctDNA analysis was performed using a tumor-informed 16 multiplex PCR next-generation sequencing assay. A total of 324 plasma samples were analyzed from 74 patients in this cohort. The majority had stage I disease, around 40 percent, and nonseminomatous histology, around 70 percent. 15 patients were evaluated in the pre-orchiectomy window, and only one patient tested negative for ctDNA. This patient had stage I disease. The authors further assessed ctDNA positivity in both the MRD window and surveillance window, evaluating its association with event-free survival. They found that ctDNA outperformed serum tumor markers in both settings. ctDNA positivity was associated with significantly worse event-free survival compared with ctDNA-negative patients. Among the 14 patients with stage II to III disease who had ctDNA assessed in both the MRD window and surveillance window, nine patients consistently had a negative ctDNA or converted from positive to negative over time. In contrast, five patients demonstrated persistent ctDNA positivity, and all of these patients subsequently relapsed. Among the 38 patients who had both ctDNA and serum tumor marker tests during the MRD window, nine patients showed discordant biomarker results. Of these, 6 patients were ctDNA-negative but serum tumor marker-positive, and one of them experienced recurrence. Three patients were ctDNA-positive but serum tumor marker-negative, and one of these patients also recurred. During the surveillance window, 46 patients had both biomarkers available, and 10 showed discordant results. Three patients were ctDNA-negative but serum tumor marker-positive, and none of them recurred. In contrast, all seven patients who were ctDNA-positive but serum tumor marker-negative experienced recurrence. This intriguing data strongly support the potential role of ctDNA in patients with stage I, II, and III germ cell tumors. However, as the authors noted, the retrospective nature of the study presents limitations, as treatment approaches, imaging schedules, and the timing of testing were not standardized, and ctDNA testing varies among participating institutions. Larger prospective trials with standardized protocols and long-term follow-up will be essential to validate these findings and determine how ctDNA can be reliably integrated into clinical practice. Thank you for tuning in to JCO Precision Oncology Article Insights. Don't forget to subscribe and join us next time as we explore more groundbreaking research shaping the future of oncology. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. What is ovarian hyperstimulation syndrome (OHSS)? OHSS is a condition that can occur after ovarian stimulation, most often during IVF cycles, when the ovaries respond excessively to fertility medications. Who is at highest risk for OHSS? Patients at increased risk include women with a high egg count, younger patients, and patients with PCOS (polycystic ovary syndrome). Does pregnancy increase the risk of OHSS? Yes; a fresh embryo transfer can increase the risk because the pregnancy hormone (hCG) may worsen or prolong OHSS symptoms. How has the risk of OHSS decreased in modern IVF treatment? The use of GnRH agonist (Lupron) trigger shots has dramatically reduced the risk by quickly lowering estrogen levels and preventing severe symptoms. How is OHSS treated? Treatment focuses on symptom management; medications such as cabergoline (Dostinex) and letrozole may be used to lower estrogen levels and shorten symptom duration. When should patients call their doctor about OHSS symptoms? Patients should call immediately if they experience low urine output, an inability to drink fluids, severe abdominal pain, shortness of breath, or pain or swelling in the arms or legs. Why is it important to call your doctor if you are concerned? OHSS can be serious, and early evaluation and treatment are critical. Patients should always contact their doctor if they are worried about symptoms. This podcast was sponsored by U.S. Fertility.
Send me a text! I'd LOVE to hear your feedback on this episode!When a good man turns quiet, slower to recover, and oddly distant, most couples assume it's attitude or boredom or maybe even an affair. What if the real story is hormones, sleep debt, vascular strain, and stress chemistry reshaping mood, identity, and connection? I take a clear-eyed look at men's midlife health - why testosterone can decline earlier than you think, how visceral fat and alcohol accelerate the slide, and why erectile dysfunction often points to cardiovascular issues long before it's “just a bedroom problem.”I walk through the signals men tend to ignore: loss of morning erections, irritability, low motivation, social withdrawal, brain fog, and that nagging sense of not feeling like yourself. I break down the difference between being “in range” and being optimized in your bloodwork, and outline the lab panels that actually guide change. This conversation also moves into the heart of relationships. When physiology changes, partners often feel rejected or unseen; understanding the body's role shifts the frame from blame to teamwork. We talk about men's reluctance to seek help, the data on midlife suicide risk, and how therapy that gives tools can rebuild agency. On treatment paths, I cover the trade-offs of testosterone therapy, why some consider HCG, and the importance of retesting every quarter so decisions follow data, not hype.If you're aiming to age well together, start here: measure what matters, protect sleep, lift regularly, drink less, and choose friends who support your goals. Share this with someone you love, hit follow, and leave a quick review to help more couples find their reset. What's the first change you'll make this week?Support the showPlease rate & review my podcast with a few kind words on Apple or Spotify. Subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgRumble: https://rumble.com/c/c-5461001Linkedin: https://www.linkedin.com/in/sandyknutrition/Substack: https://sandykruse.substack.com/Podcast Website: https://sandykruse.ca
HCG is a heterodimeric glycoprotein typically produced by trophoblastic tissue. However, there are occasions where a serum HCG is obtained that remains low level POSITIVE, yet the patient is not pregnant, nor does she have a gynecologic malignancy. Why dose this happen. Not all these instances can be explained by the “PHANTOM” HCG. In this episode, we will review a new Clinical Consensus guideline from the ACOG officially being released in Feb 2026. Like the finding of an aberrant aneuploidy on cell-free DNA testing in pregnancy (NIPT) where the child is found to NOT be affected, where that abnormal result may signal a hidden malignancy, a persistent low level positive HCG that cannot be explained by pregnancy or a gyn cancer may signal a hidden malignancy elsewhere. Listen in for details. 1. ACOG CC #11, February 2026
Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. In this episode, our docs take a deep dive into one of the most pivotal decisions in an IVF cycle: when and how to trigger for egg retrieval. They break down the thought process behind choosing between an HCG trigger and a Lupron trigger, explaining why the choice isn't one-size-fits-all. One of the biggest advantages of a Lupron trigger is its ability to dramatically reduce the risk of ovarian hyperstimulation syndrome (OHSS), a key consideration for patients with a high response to medication. But Lupron doesn't work for everyone. The docs explain why patients with hypothalamic amenorrhea must use HCG to ensure proper follicle release, and why a fresh embryo transfer also requires an HCG trigger for optimal luteal support. The docs also discuss the many clinical clues that guide trigger timing. These include a patient's historical response to stimulation, whether they're planning a fresh or frozen transfer, and crucial hormonal cues such as a drop in estrogen that can signal impending ovulation. They even share how sometimes they bring patients into the office for an ultrasound on retrieval day to confirm that spontaneous ovulation hasn't occurred. Finally, they cover the selective use of combined HCG + LH triggers, and which patients benefit most from this approach. This is a must-listen for anyone wanting a behind-the-scenes look at how reproductive endocrinologists make one of the most important calls in an IVF cycle. This podcast was sponsored by US Fertility.
Dr. Pedro Barata and Dr. Aditya Bagrodia discuss the evolving landscape of testicular cancer survivorship, the impact of treatment-related complications, and management strategies to optimize long-term outcomes and quality of life. TRANSCRIPT: Dr. Pedro Barata: Hello and welcome to By the Book, a podcast series from ASCO that features engaging conversations between editors and authors of the ASCO Educational Book. I'm Dr. Pedro Barata. I'm a medical oncologist at University Hospitals Seidman Cancer Center and associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. We all know that testicular cancer is a rare but highly curable malignancy that mainly affects young men. Multimodal advances in therapy have resulted in excellent cancer specific survival, but testicular cancer survivors face significant long term treatment related toxicities which affect their quality of life and require surveillance and management. With that, I'm very happy today to be joined by Dr. Aditya Bagrodia, a urologic oncologist, professor, and the GU Disease Team lead at UC San Diego[KI1] Health, and also the lead author of the recently published paper in the ASCO Educational Book titled, "Key Updates in Testicular Cancer: Optimizing Survivorship and Survival." And he's also the host of the world-renowned BackTable Urology Podcast. Dr. Bagrodia, I'm so happy that you're joining us today. Welcome. Dr. Aditya Bagrodia: Thanks, Pedro. Absolutely a pleasure to be here. Really appreciate the opportunity. Dr. Pedro Barata: Absolutely. So, just to say that our full disclosures are available in the transcript of this episode. Let's get things started. I'm really excited to talk about this. I'm biased, I do treat testicular cancer among other GU malignancies and so it's a really, really important topic that we face every day, right? Fortunately, for most of these patients, we're able to cure them. But it always comes up the question, "What now? You know, scans, management, cardio oncology, what survivorship programs we have in place? Are we addressing the different survivorship piece, psychology, fertility, et cetera?" So, we'll try to capture all of that today. Aditya, congrats again, you did a fantastic job putting together the insights and thoughts and what we know today about this important topic. And so, let's get focused specifically about what happens when patients get cured. So, many of us, in many centers, were fortunate enough to have these survivorship programs together, but I find that sometimes from talking to colleagues, they're not exactly the same thing and they don't mean the same thing to different people, to different institutions, right? So, first things first. What do you tell a patient perhaps when they ask you, "What can happen to me now that I'm done with treatment for testicular cancer?" Whether it's chemotherapy or just surgery or even radiation therapy? "So, what about the long term? What should I expect, Doctor, that might happen to me in the long run?" Dr. Aditya Bagrodia: Totally. I mean, I think that question's really front and center, Pedro, and really appreciate you all highlighting this topic. It was an absolute honor to work with true thought leaders and the survivorship bit of it is front and center, in my opinion. It's really the focus, you know, we, generally speaking should be able to cure these young men, but it's the 10, 15, 20 years down the way that they're going to largely contend with. The conversation really begins at diagnosis, pre-education. Fortunately, the bulk of patients that present are those with stage one disease, and even very basic things like before orchiectomy, talking about a prosthetic; we know that that can impact body image and self esteem, whether or not they decide to receive it or not. Actually, just being offered a prosthetic is important and this is something, you know, for any urologist, it's kind of critical. To discussing fertility elements to this, taking your time to examine the contralateral testicle, ask about fertility problems, issues, concerns, offer sperm banking, even in the context of a completely normal contralateral testicle, I think these things are quite important. So if it's somebody with stage one disease, you know, without going too far down discussing adjuvant therapy and so forth, I will start the conversation with, "You know, the testes do largely two things. They make testosterone and they make sperm." By and large, patients are going to be able to have acceptable levels of testosterone, adequate sperm parameters to maintain kind of a normal gonadal state and to naturally conceive, should that be something they're interested in. However, there's still going to be, depending on what resource you look at, somewhere in the order of 10-30% that are going to have issues. Where I think for the stage one patients, it's really incumbent upon us is actually to not wait for them to discuss their concerns, particularly with testosterone, which many times can be a little bit vague, but to proactively ask about it every time. Libido, erectile quality, muscle mass maintenance, energy, fatigue. All of these are kind of associated symptoms of hypogonadism. But for a lot of kids 18-20 years old, it's going to be something insidious that they don't think about. So, for the stage one patients, it absolutely starts with gonadal function. If they are stage two getting surgery, I think the counseling really needs to center around a possibility for ejaculatory dysfunction. Now, for a chemotherapy-naive, nerve-sparing RPLND, generally these days we should be able to preserve ejaculatory function at high volume centers, but you still want to bring that up and again kind of touch base on thinking about sperm banking and so forth before the operation, scars, those are things I think worth talking about, small risk of ascites. Then, I think the intensity of potential long term adverse effects really ramps up when we're talking about systemic therapy, chemotherapy. And then there's of course some radiation therapy specific elements that come up. So, for the chemotherapy bits of it, I really think this is going to be something that can be a complete multi-system affected intervention. So, anxiety, depression, our group has actually shown using some population resources that even suicidality can be increased among patients that have been treated for germ cell tumor. You know, really from the top down, tinnitus, hearing changes, those are things that we need to ask about at every appointment. Neuropathy, sexual health, that we kind of talked about, including ED (erectile dysfunction), vertigo, dizziness, Raynaud's phenomenon, these are kind of more the symptoms that I think we need to inquire about every time. And what we do here and I think at a lot of survivorship programs is use kind of a battery of validated instruments, germ cell tumor specific, platinum treated patient specific. So we use a combination of EORTC questions and PROMIS questions, which actually serves as like a review of systems for the patient, also as a research element. We review that and then depending on what might be going on, we can dig into that further, get them over to colleagues in audiology or psychology, et cetera. And then of course, screening for the hypertension, hyperlipidemia, metabolic syndrome with basically you or myself or somebody kind of like us serving, many times it's the role of the PCP, just making sure we're checking out, you know, CBC, CMP, et cetera, lipid parameters to screen for those kind of cardiac associated issues along with secondary malignancies. Dr. Pedro Barata: So that's super comprehensive and thorough. Thank you so much. Actually, I love how you break it down in a simple way. Two functions of the testes, produce testosterone and then, you know, the problem related to that is the hypogonadism, and then the second, as you mentioned, produce sperm and of course related to the fertility issues with that. So, let's start with the first one that you mentioned. So, you do cite that in your paper, around 5-10% of men end up getting, developing hypogonadism, maybe clinical when they present with symptoms, maybe subclinical. So, I'm wondering, for our audience, what kind of recommendations we would give for addressing that or kind of thinking of that? How often are you ordering those tests? And then, when you're thinking about testosterone replacement therapy, is that something you do immediately or are there any guidelines into context that? How do you approach that? Dr. Aditya Bagrodia: So, just a bit more on digging into it even in terms of the questions to ask, you know, "Do you have any decrease in sexual drive? Any erectile dysfunction? Are your morning erections still taking place? Has the ejaculate volume changed? Physically, muscle mass, strength? Have you been putting on weight? Have you noticed increase in body fat?" And sometimes this is complicated because there's some anxiety that comes along with a cancer diagnosis when you're 20, 30 years old, multifactorial, hair loss, hot flashes, irritability. Sometimes they'll, you know, literally they'll say, "You know, my significant other or partners noticed that I'm really just a little bit labile." So I think, you know, there's the symptoms and then checking, usually kind of a gonadal panel, FSH, LH, free and total testosterone, sex hormone binding globulin, that's going to be typically pretty comprehensive. So if you've got symptoms plus some laboratory work, and ideally that pre-orchiectomy testosterone gives you some delta. If they started out at an 800, 900, now they're 400, that might be a big change for them. And then, when you talk about TRT (Testosterone Replacement Therapy) recommendations, you know, Pedro, yourself, myself, we're kind of lucky to be at academic centers and we've got men's health colleagues that are ultra experts, but at a high level, I would say that a lot of the TRT options center around fertility goals. Exogenous testosterone treats the low T, but it does suppress gonadal function, including spermatogenesis. So if that's not a priority, they can just get TRT. It should be done under the care of a urologist, a men's health, an endocrinologist, where we're checking liver chemistries and CBCs and a PSA and so forth. If they're interested in fertility preservation, then I would say engaging an endocrinologist, men's health expert is important. There's medications even like hCG, Clomid, which works centrally and stimulate the gonadal access. Niche scenarios where they might want standard TRT now, and then down the way, 5, 7 years, they're thinking about coming off of that for fertility purposes, I think that's really where you want to have an expert involved because there's quite a bit of nuance there in recovery of actual spermatogenesis and so forth. To kind of summarize, you got to ask about it. Checking it is, is not overly complicated. We do a baseline pre-orchiectomy and at least once annually, you can tag it in with the tumor markers, so it's not an extra blood draw. And if they have symptoms of course, kind of developed, then we'll move that up in the evaluation. Dr. Pedro Barata: Got it. And you also touch base on the fertility angle, which is truly important. And I'm just curious, you know, a lot of times many of us might see one, two patients a year, right, and we forget these protocols and what we've got to do about that. And so I'm interested to hear your thoughts about when you think about fertility, and how proactive you get. In other words, who do you refer for the fertility clinic, for a fertility preservation program? You know, do all cases despite getting through orchiectomy or just the cases that you're going to, you know you're going to seek chemotherapy at some point? What kind of selection or it depends on the chemo, like how do you do that assessment about the referral for preservation program that you might have available at UCSD? Dr. Aditya Bagrodia: Yeah, I mean I feel really fortunate to sit on the NCCN Testis Cancer Guidelines. It's in there that fertility counseling should be discussed prior to orchiectomy. So 100% bring it up. If there are risk factors, undescended testicles, previous history of fertility concerns, atrophic contralateral testicle, anything on the ultrasound like microlithiasis in the contralateral testicle, you kind of wanna get it there. And then again, there's kind of niche scenarios where you're really worried, maybe get a semen analysis and it doesn't look that good, arrange for the time of orchiectomy to have onco-testicular sperm extraction from the, quote unquote, "normal" testis parenchyma. You know, I think you have to be kind of prepared to go that route and really make sure you're doing this completely comprehensively. So pre-orchiectomy all patients. Don't really push for it too hard if they've got a contralateral testicle, if they've had no issues having children. There's some cost associated with this, sperm banking still isn't kind of covered even in the context of men with cancer. If they've got risk factors, absolutely pre-orchiectomy. Pre-RPLND, even though the rates of ejaculatory dysfunction at a high-volume center should be low single digits, I'll still offer it. That'd be a real catastrophe if they were in that small proportion of patients and now they're going to be reliant on things like intrauterine insemination, where it becomes quite expensive. Pre-chemo, everybody. That's basically a standard these days where it should be discussed and it's kind of amazing currently, even if you don't have an accessible men's health fertility clinic, there are actually companies, I have no vested interest, Fellow is one such company where you can actually create an account, receive a FedEx semen analysis and cryopreservation kit, send it back in, and all CLIA certified, it's based out of California. The gentleman that runs it, is a urologist and very, very bright guy who's done a lot of great stuff for testis cancer. So, even for patients that are kind of in extremis at the hospital that kind of need to get going like yesterday, we still discuss it. We've got some mechanisms in place to either have them take a semen analysis over to our Men's Health clinic or send it off to Fellow, which I think is pretty cool and that even extends to some of our younger adolescent patients where going to a clinic and providing a sample might be tricky. So, I think bringing it up every stage, anytime there's an intervention that might be offered, orchiectomy, chemo, surgery, radiation, it's kind of incumbent on us to discuss it. Dr. Pedro Barata: Gotcha. That's super helpful. And you also touch base on another angle, which is the psychosocial angle around this. You mentioned suicidal rates, you mentioned anxiety, perhaps depression in some cases as well as chronic fatigue, not necessarily just because of the low testosterone that you can get, but also from a psychological perspective. I'm curious, what do the recommendations look like for that? Do these patients need to see a social worker or a psychologist, or do they need to answer a screening test every time they come to see us and then based on that, we kind of escalate, take the next steps according to that? Do they see a psychologist perhaps every so often? How should that be managed and addressed? Dr. Aditya Bagrodia: It's an excellent question and again, these can be rather insidious symptoms where if you don't really dig in and inquire, they can be glossed over. I mean, how easy to say, "Your markers look okay, your scans look okay. See you in six months," and keep it kind of brief. First off, I think bringing it up proactively and normalizing it, that, "This may be something that you experience. Many people do, you're not alone, there's nothing kind of wrong with you." I also think that this is an area where support groups can be incredibly useful. We host the Testicular Cancer Awareness Foundation support group here. They'll talk about chemo brain or just like a little bit of an adjustment disorder after their diagnosis. Support groups, I think are critical. As I mentioned, we have a survivorship program that's led by a combination of our med oncs, myself on the uro-onc side, as well as APPs, where we are systematically asking about essentially the whole litany of issues that may arise, including psychosocial, anxiety, depression, suicidality. And we've got a nice kind of fast path into our cancer center support services for these young men to meet with a psychologist. If that isn't going to be sufficient, they can actually see a psychiatrist to discuss medications and so forth. I do think that we've got to screen for these because, as anticipated from diagnosis, those first 2 years, we see a rise. But even 10, 15 years out, we note, compared to controls, that there is an increased level of anxiety, depression, suicidality that might not just take place at that initial acute period of diagnosis and treatment. Dr. Pedro Barata: Really well said. Super important. So I guess if I were to put all these together, with these really amazing advances in technology, we all know AI, some of us might be more or less aware of biomarkers coming up, including microRNA for example, and others, like as I think of all these potential long term complications for these patients, look at the future, I guess, can we use this as a way to deescalate treatment where it's not really necessary, as a way to actually prevent some of these complications? Like, how do we see where we're heading? As we manage testicular cancer, let's say, within the next 5 or 10 years, do you think there's something coming up that's going to be different from what we're doing things today? Dr. Aditya Bagrodia: Totally. I mean, I think it's as exciting as a time as there's ever been, you know, maybe notwithstanding circa 1970s when platinum was discovered. So microRNAs, which you mentioned, you know, there's a new candidate biomarker, microRNA-371. We are super excited here at UCSD. We actually have it CLIA-certified available in our lab and are ordering these tests for patients kind of in their acute stage, you know, stage one and surveillance, stage two, post-RPLND, receiving chemotherapy. And essentially this is a universal germ cell tumor specific biomarker, except for teratoma, suffice it to say 90% sensitive and specific. And I think it's going to change the way that we diagnose and manage patients. You know, pre-orchiectomy, that's pretty straightforward. Post-orchiectomy, maybe we can really decrease the number of CT scans that are done. Maybe we can identify those patients that basically have occult disease where we can intervene early, either with RPLND or single cycle chemo. Post-RPLND, identify the patients who are at higher risk of relapse that may benefit from some adjuvant therapy. In the advanced setting, look at marker decline for patients in addition to standard tumor markers. Can we modulate their systemic therapy? So, the international interest is largely on modifying things. There's really cool clinical trials that we have for stage one patients, that treatment would be prescribed based on a post-orchiectomy microRNA. I think the microRNAs are really exciting. Teratoma remains an outstanding question. I think this is where maybe ctDNA, perhaps some radiomics and advanced imaging processing and incorporating AI may allow us to safely avoid a lot of these post-chemo RPLNDs. And then identification using SNPs and so forth of who might be most susceptible to some of the cardiac toxicity, autotoxicity and personalizing things in that way as well. Dr. Pedro Barata: Super exciting, right, what's about to come? And I agree with you, I think it's going to change dramatically how we manage this disease. This has been a pleasure sitting down with you. I guess before letting you go, anything else you'd like to add before we wrap it up? Dr. Aditya Bagrodia: Yeah, first off, again, just want to thank you and ASCO for the opportunity. And it's easy enough to, I think, approach a patient with the testicular germ cell tumor as, "This is an easy case. We're just going to do whatever we've done. Go to the guidelines that says do X, Y, or Z." But there's so much more nuance to it than that. Getting it done perfectly, I think, is mandatory. Whatever we do is an impact on them for the next 50, 60, 70 years of their life. And I found the germ cell tumor community, people are really passionate about it. If you're ever uncertain, there's experts throughout the country and internationally. Ask somebody before you do something that you can't undo. I think we owe it to them to get it perfect so that we can really maximize the survivorship and the survival like we've been talking about. Dr. Pedro Barata: Aditya, thanks for sharing your fantastic insights with us on this podcast. Dr. Aditya Bagrodia: All right, Pedro. Fantastic. Appreciate the opportunity. Dr. Pedro Barata: And also, thank you to our listeners for your time today. I actually encourage you to check out Dr. Bagrodia's article in the 2025 ASCO Educational Book. We'll post a link to the paper in the show notes. Remember, it's free access online, and you can actually download it as well as a PDF. You can also find on the website a wealth of other great papers from the ASCO Educational Book on key advances and novel approaches that are shaping modern oncology. So with that, thank you everyone. Thank you, Aditya, one more time, for joining us. Thank you, have a good day. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers: Dr. Pedro Barata @PBarataMD Dr. Aditya Bagrodia @AdityaBagrodia Follow ASCO on social media: @ASCO on X (formerly Twitter) ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck Dr. Aditya Bagrodia: Consulting or Advisory Role: Veracyte, Ferring
Welcome back to another sneak peek of the upcoming ASRM Conference. Today, we welcome Dr. Erkan Buyuk back to the show to hear about his abstract at the ASRM Conference titled, ‘Time to Undetectable HCG Following Early Pregnancy Loss in ART Pregnancies: A Comparison of Management Strategies.' Tuning in, you'll hear about this one-of-a-kind study, the delicate way doctors have to handle miscarriages, the three options patients have after finding out a pregnancy isn't viable, and so much more! Our guest shares what inspired him to conduct this study before delving into some of its findings. We even discuss how this study has helped us have a better understanding of when HCG levels will reduce after miscarriage. Finally, our guest tells us what we can expect in the future from this study and shares what he is grateful for today. Thank you for listening!
We challenge long-held beliefs about fibroids, highlight new ectopic pregnancy nuances, and dig into real-world dermoid cyst outcomes. We also unpack the evidence and ethics of 39-week induction after IVF and ICSI, balancing small absolute risks with maternal tradeoffs.• Evidence overturning links between fibroids and miscarriage, PROM and abruption• Distinguishing spontaneous versus iatrogenic preterm birth in fibroid pregnancies• Why myomectomy can raise early delivery and cesarean rates in some patients• Ectopic care updates: tube-sparing choices, HCG thresholds, two-dose methotrexate• Experimental adjuncts to methotrexate remain unproven• Dermoid data supporting laparoscopy, irrigation, and specimen bags over open surgery• Surgical decision making during pregnancy and avoiding uterine manipulators• IVF and ICSI timing: late stillbirth risk signals, limits of testing, 39-week logic• Shared decision making when absolute risks are low but values differBe sure to check out thinkingaboutobgyn.com for more information and be sure to follow us on Instagram1:33 Fibroids And Miscarriage Myths5:53 Preterm Birth, PROM, And Hemorrhage9:31 Myomectomy: Risks, Scars, And Outcomes13:25 Ectopic Pregnancy: What's New18:37 Surgery Versus Methotrexate Nuances22:05 Experimental Add-Ons To Medical Therapy27:47 Dermoid Cysts: Real-World Data32:48 Laparoscopy, Spillage, And Pregnancy36:06 When Open Surgery Makes Things Worse40:34 IVF, ICSI, And 39-Week Induction48:05 Stillbirth Risk: What The Data Shows55:20 Testing, Timing, And Shared Decisions1:04:10 Practical Counseling And TradeoffsFollow us on Instagram @thinkingaboutobgyn.
Watch the FULL podcast here: https://youtu.be/Lw6iZbZBiw8Thinking about TRT for low testosterone? This clip takes a closer look at who genuinely benefits from testosterone replacement therapy, what current evidence suggests about safety, and why fertility planning is crucial.I'm exploring with my guest how to distinguish primary from secondary hypogonadism, why symptoms plus true biochemical low testosterone are needed for a diagnosis, and the point that if total testosterone is above 12, TRT isn't indicated. This discussion focuses on updated data around prostate and cardiovascular risk, key contraindications such as active prostate cancer, polycythemia, and heart failure, and the reality that exogenous testosterone suppresses FSH and sperm production, acting like a male contraceptive and not always fully reversible. We also cover off-label options like clomiphene and hCG to support endogenous testosterone when fertility is a priority, the importance of screening for metabolic issues like dyslipidemia and prediabetes, lifestyle considerations, and the social pressures that drive recreational use. There's a brief reflection on age-related declines, the idea that testosterone may drop after men have children, and how broader environmental factors might fit into the picture.As a nutritionist and health communicator, I aim to connect the science with practical, balanced advice so you can discuss options confidently with your clinician.***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***Sign up to Sarah's Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/***Let's be friends!
Testosterone Replacement Therapy can feel confusing—especially with conflicting advice online. In this beginner-friendly episode, Dave Lee explains what TRT is, when it's truly needed, and why it's a lifelong medical therapy. He covers the core decision point (optimize lifestyle first vs. start TRT), what “good” protocols look like (stable levels via frequent low-dose injections or 20% trans-scrotal cream), and the red flags to avoid (infrequent injections, cookie-cutter add-ons like routine HCG and aromatase inhibitors, pellets/patches/gels with poor efficacy). Dave lays out the habits that make TRT work—sleep, protein-forward nutrition, steps, cardio, and resistance training—and clears up the biggest myth around fertility, including how it can usually be restored while staying on treatment. If you're considering TRT or just had low T labs, this is your practical roadmap—and why working with a true expert matters. Dave Lee's Website Click Here Victory Men's Health Click Here Victory Men's Health YouTube For questions email podcast@amystuttle.com Disclaimer: The Women Want Strong Men Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
Send us a textCan you really boost your IVF success rate by doing everything before an embryo transfer? In this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols breaks down one of the most common misconceptions in fertility treatment — the belief that more testing automatically means better results. From ERA and Receptiva testing to add-ons like PRP or HCG washes, Dr. Amols explains why these extra steps can't push your chances beyond what the embryo already has — because you can't beat the math.Using simple numbers, national success rate data, and a memorable coin-flip analogy, he helps you understand how cumulative odds really work, when testing does make sense, and why giving “120%” isn't possible in IVF. Whether you're preparing for your first transfer or recovering from a failed one, this episode will help you focus on what truly improves your chances — patience, persistence, and perspective.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.
What if the most important step after pregnancy loss isn't “try again,” but being truly seen and given a thoughtful plan? In this special episode for Pregnancy & Infant Loss Awareness Month, Dr. Monica Minjeur shares how restorative reproductive medicine supports women with cycle-informed evaluation, timed hormone labs, thyroid and insulin testing, male factor assessment, and screening for chronic endometritis—often missed in standard care. With compassion and clarity, discover how to build a plan that honors your grief while restoring your body's ability to heal and conceive.Key TakeawaysCompassion first: Honor grief, name the baby if desired, and move at your own pace.Cycle-informed evaluation: Use charting to assess ovulation return, luteal phase strength, fertile signs, and bleeding patterns (especially brown bleeding).Timed hormone labs: Check progesterone and estradiol ~7 days after ovulation to assess ovulation quality—not just “day 21” labs.Thyroid & insulin matter: Full thyroid panel (TSH, Free T4, Free/Total T3, antibodies) and insulin testing (fasting or OGTT with insulin).Screen for chronic endometritis: Especially if there's brown bleeding, early loss, or heavy cycles. Consider menstrual testing, biopsy, or hysteroscopy.Male factor is essential: Include semen analysis and DNA fragmentation testing, even if conception occurred.Re-testing is critical: Confirm improvements after treatment—labs, charting, and symptom resolution all guide timing.When to try again: A shared decision—emotionally ready, physically supported, with a clear plan for early pregnancy monitoring (HCG, progesterone, estradiol).If you've experienced pregnancy loss and feel like you're navigating it alone or without answers, we're here to help. At Radiant Clinic, we combine compassionate care with cycle-informed, restorative evaluation to create a plan designed for your body and your story. Schedule your free discovery call at radiantclinic.com
Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. Featuring Dr. Sherman Silber, MD, founder of the Silber Fertility Institute in St. Louis. This episode features Dr. Sherman Silber, an internationally recognized pioneer in infertility treatment who has dedicated his career to helping patients overcome the challenges of female aging and diminished ovarian reserve. Dr. Silber shares how minimal stimulation protocols—using very small doses of gonadotropins combined with daily Clomid—can offer new hope for women with decreased ovarian reserve or premature ovarian insufficiency. He explains why HCG plays a crucial role in egg maturation, particularly for women with very low egg numbers, and why using lower amounts of medication may actually improve outcomes. Dr. Silber also looks to the future, discussing cutting-edge research that may enable the transformation of fibroblasts into eggs and sperm—an innovation that could redefine fertility treatment within the next 10–15 years. With decades of groundbreaking work behind him, Dr. Silber offers both practical guidance for today and visionary insights for tomorrow. This podcast was sponsored by IVF Florida
The Barbell Mamas Podcast | Pregnancy, Postpartum, Pelvic Health
The room got quieter when the number landed: HCG at 5,000—far too low for nearly thirteen weeks. From that moment, everything we'd been planning—the crib shuffle in our three-bedroom house, the baby names our kids were arguing over, the assumption we'd crossed into a “safe zone”—shifted into the harsh clarity of a missed miscarriage. We're sharing the story we needed to hear: what the ER limbo feels like, how bedside ultrasound can foreshadow a formal diagnosis, and why lab values can be both information and heartbreak.We walk through the real choices families face after pregnancy loss: expectant management and its long, uncertain timeline; medical management with misoprostol, including what the pain, bleeding, and safety thresholds actually feel like at home; and surgical management via D&C when speed, tissue testing, or medical necessity make it the right call. Along the way we talk about follow-up plans, HCG monitoring, when to seek help, and how to make decisions that match your values, schedule, support system, and mental health. This is practical, compassionate guidance from people who just carried it.You'll also hear the partner's perspective—what it's like to hold hope in a waiting room, to field waves of well‑meant messages, and to grieve a child without the physical markers of loss. We share how we told our kids, why simple rituals like a barefoot hike helped, and how community support can be both overwhelming and lifesaving. If you've been here, you're not alone. If you haven't, this conversation can help you support someone who has with empathy instead of minimization.Subscribe for more honest, evidence‑informed conversations on pregnancy, postpartum, pelvic health, and strength. If this episode resonates, share it with someone who needs it and leave a review to help others find these stories.___________________________________________________________________________Don't miss out on any of the TEA coming out of the Barbell Mamas by subscribing to our newsletter You can also follow us on Instagram and YouTube for all the up-to-date information you need about pelvic health and female athletes. Interested in our programs? Check us out here!
Hey sister! Today we are replaying #5 of the most downloaded episodes of all time! In this episode, I break down five powerful ways to naturally support your progesterone… and flood you with some Biblical encouragement to remind you that your identity and purpose goes far beyond a positive pregnancy test. I also discuss how to increase your progesterone levels naturally without immediately jumping into medications or IVF. Maybe you've had a miscarriage or you suspect low progesterone and want to understand what's going on inside your body, and most importantly, what you can do about it. Episode Highlights: What progesterone actually does in your cycle and early pregnancy How the corpus luteum and HCG interact to sustain a healthy pregnancy Specific prayers to speak over your body and cycle Lifestyle changes that really support hormone balance Why being still before God (Psalm 46:10) matters more than you think Plus, I'm reminding you that your purpose is to glorify God, whether you're a mama now or still waiting. You are not forgotten. He is sovereign over your womb, your hormones, your future baby, and every part of your story. Resources & Links: ✨If you're curious about your personal hormone health, take my free Hormone Quiz: bekahyawn.com/quiz ✨ Join Fertility Framework: If you're ready for deeper support, personalized cycle guidance, and faith-filled encouragement, come join me inside Fertility Framework! This is a space where you AND your husband can learn about the science of your cycle while keeping God in the centre of your fertility journey and growing towards Him together. Read the testimonies & enroll here: www.bekahyawn.com/course ✨If you would like personal support on your journey but are not sure how to get started, book a free 10-minute consult with me here: www.bekahyawn.com/consult ✨ I've put together a free faith-filled booklet to help guide you through this journey. It's called Faith-Driven Fertility, and it's full of practical steps and encouragement for trusting God while supporting your body for conception.
Send us a textIn this week's episode of Taco Bout Fertility Tuesday, Dr. Mark Amols takes you on a guided tour of your baby's very first pictures—the first trimester ultrasound. From the tiny gestational sac to the yolk sac (your baby's first lunchbox), to the fetal pole and that reassuring flicker of a heartbeat, Dr. Amols explains what each step really means and when you should expect to see it. You'll also learn:Why we stop checking hCG once we see the sacWhat it means if a yolk sac is missing or measures unusually small or largeHow to understand the fetal pole and when to expect a heartbeatGrowth benchmarks from “grain of rice” to “strawberry”Why being 3–7 days behind may (or may not) be concerningHow and why the placenta forms, and when we can actually see itWhat nuchal translucency is, what causes it, and what it does—and doesn't—meanOne ultrasound is just a snapshot, but together they create the story of the first trimester. If you've just found out you're pregnant—or you're supporting someone who has—this episode will help you decode what's on the screen and know what to expect in those exciting early weeks.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.
Male fertility is declining — and it's time we start talking about it! In this powerful and eye-opening conversation, we dive deep into the often-overlooked side of fertility: Men's Reproductive Health. From falling testosterone levels in younger men to environmental toxins, stress, poor sleep, and overlooked medical factors, we unpack the hidden reasons why male fertility is struggling — and, most importantly, what you can do about it.Joining me in this episode is Dr. Deb Matthew! Dr Deb Matthew, MD, America's Happy Hormones Doctor, is a best-selling author, international speaker, educator, wife, and mom of four boys. After suffering for years with fatigue and irritability due to hormone imbalances, her quest to resolve her personal health led her to change everything about her practice of medicine. She has been featured on national podcasts, radio, and broadcast shows, including NBC, ABC, CBS, PBS, and FOXIn this episode, you'll discover:The surprising symptoms of low testosterone (even in your 20s & 30s)Why “normal” testosterone levels aren't always optimal for fertilityThe dangerous effects of chronic stress and high cortisol on sperm healthHow toxins in plastics, cleaning products, and personal care items disrupt hormonesThe connection between inflammation, oxidative stress, and sperm qualityMedications that may be silently impacting testosterone, libido, and fertilityHow nutrition, targeted supplements, and lifestyle changes can make a massive differenceWhen to consider medical treatments like HCG or Clomiphene — and when to avoid testosterone replacement
Send us a textYou finally got the positive test after IVF or IUI — now what? In this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols walks you through the first steps after a positive pregnancy test, from confirming with beta hCG bloodwork to your first ultrasound. Learn why rising numbers matter more than the absolute hCG value, why it's crucial not to stop progesterone or estrogen too early, and what milestones to expect in the first 6–10 weeks.Dr. Amols also shares common myths, tips for healthy habits, and insight into the emotional rollercoaster of “graduating” from your fertility clinic to your OB. Whether you've just seen those two pink lines or are preparing for this moment, this episode offers practical guidance, reassurance, and hope for your next chapter.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.
El dengue es una enfermedad que se transmite a través de la picadura de los mosquitos hembras pertenecientes a las especies Aedes aegypti. Pueden presentarse síntomas como fiebre, dolor de cabeza (detrás de los ojos), malestar generalizado, dolor en articulaciones, dolor en músculos, enrojecimiento en la piel, náusea, vómito y pérdida del apetito, y en casos graves sangrado por nariz o encías, o moretones en la piel. En este podcast de El Expresso de las 10, nuestros especialistas; la Dra. Melva Guadalupe Herrera Godina, Coordinadora de la Maestría en Salud Pública del CUCS en la UDG, el Dr. Mario Márquez Coordinador General de Epidemiología del Hospital Civil de Guadalajara Fray Antonio Alcalde, el Dr. Esteban González Díaz, Jefe de la Unidad de Vigilancia Epidemiológica Hospitalaria y Medicina Preventiva del HCG y el doctor Roberto Carlos Rivera Ávila, Director General de Salud Pública de la Secretaría de Salud Jalisco; brindan información muy valiosa para cuidar a tu familia del dengue.
Join us for a deep dive into the IVF patient journey with special guest Kelly Gonda, a passionate pharmacist and Fertility Nurse Practitioner. In this episode, we explore how pharmacists can improve safety, outcomes, and access to fertility treatment by understanding the science of in vitro fertilization and the medications involved.
High Deca Low Test Cycle for Strength and Size - Steroids Podcast Episode 75#bodybuilding #TRT #Muscle #Contestprep #bodybuildingpodcastMy Book:ULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING Link - https://bodybuilderinthailand.com/ultimate-guide-to-roids/Daily Text Msg Training 99/month and 1 Hour Phone Call Consult 59 Send Email to inquire about personal training to steroidspodcast@gmail.comBodybuilder in Thailand on Instagram: https://www.instagram.com/bodybuilderinthailand/My Other Podcast: Grab the Bull Podcast: https://youtu.be/X6SzfCrN4NY?si=Ho2T9WIVxLjXo_AETime Stamps:0:00 Simple Low dose cycle for maintaining a social media influencer friendly, Instagrammer look5:20 Trenbolone on the Brain in the Gym6:48 High Deca Low Test 10:00 What makes muscle grow12:14 Tren Side Effects 150mg EOD Making Muscle Gains and Leaning Out - What Being on TREN FEELS LIKE - Cosmetic Effects of TREN - TREN COUGH17:50 Using Dianabol Effectively20:12 Basic Guide to Managing e2 estradiol on cycle22:10 First Cycle 500mg test 50mg Anavar with HCG for PCT - Reconstituting Peptides24:57 Unusual Side Effects, Possible Steroid Flu29:00 Blood Pressure Monitoring tips for Bodybuilders30:25 Titrating Up in Dosages with Test E and Equipoise32:12 Long Term Cruise + for Guy at 50 years old - Effects of AGE and Steroids37:12 Quad Injections39:50 Test Prop 400 Tren Ace 400 with Retatrutide Cutting Cycle42:14 Troubleshooting when Bodyweight is Resisting Going down during a Cut43:50 Stacking Alot of Steroids Together versus only running 1 or 2 at a timeThis Podcast is for entertainment and conversational purposes only. Serious Injury and Death can occur from utilizing chemical performance enhancement. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. The purpose of this podcast is not to glorify the use of PED's but to bring to light the reality of what athletes are doing privately. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.
Ep. 188: In this episode, Greg and I are finally sharing the full story behind my pregnancy—from our IVF journey and emotional HCG scare to what it felt like watching the embryo transfer in real time. We talk about stepping back from social media, what I learned from two months offline, and how that reset helped my mental health. We also answer your questions about body image, relationship shifts, and how we're preparing for birth, parenting, and life as a growing family. This one's deeply personal, wildly honest, and full of moments we'll never forget. Come listen in—I'm so excited to share this with you. Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Greg's Instagram click here! Sponsored By: Get $100 toward Function Health — the most advanced at-home lab testing. First 1000 only: functionhealth.com/pow Get 20% off Foria's all-natural Relief Melts & Salve at foriawellness.com/POW or with code POW at checkout. This episode is sponsored by BetterHelp. Get 10% off your first month at betterhelp.com/POW and get on your way to being your best self. Sleep deeper & wake refreshed with Dream Recovery. Get an exclusive discount at dreamrecovery.io using code PURSUIT15 at checkout. Get $30 off your first Wildgrain box—plus free croissants in every box—at wildgrain.com/POW or use code POW. Skip the grocery store markup—shop Thrive Market for 30% off your first order plus a free $60 gift at thrivemarket.com/POW. Buy 4 cartons of David Protein Bars, get the 5th free—exclusively at davidprotein.com/POW. High protein, no sugar, no junk. Show Links: For a human-safe approach to home cleaning, support friend-of-the-show Branch Basics. Support digestion, fight bloat, and boost energy with Bloom Greens & Superfoods—38 ingredients packed into one delicious daily scoop. Topics discussed: 00:00:14: Mari back in the studio 00:00:55: Two month hiatus for social media 00:05:35: Embryo ranking 00:06:48: Embryo transfer 00:07:42: Finding out they're expecting 00:12:18: Can the animals sense the pregnancy? 00:13:17: The pregnancy doesn't feel real 00:14:50: How has your relationship evolved throughout the pregnancy? 00:23:07: Any reason for having to go through IVF? 00:24:00: Body image and pregnancy 00:26:54: Do you recommend IVF? 00:27:43: Baby's nursery 00:29:34: Where's Lulu? 00:30:02: Pregnancy cravings 00:32:41: Will you do IVF for future babies? 00:33:16: Biggest lesson learned giving up social media 00:36:42: Sharing your baby online 00:42:07: How thinking has shifted since expecting 00:43:37: Eating liver 00:44:09: How Mari's workouts have changed 00:45:19: How many kids do you want? 00:45:43: How did we find out the gender 00:47:02: Birthing plan 00:48:23: Still a firm believer in pomegranate juice and seeds? 00:48:41: Home birth? 00:49:08: Transfer success advice 00:51:06: Progesterone shots 00:52:03: Due date 00:52:05: Bloom prenatal?
Ep. 187: I've been holding onto this news for what feels like forever, and I'm finally ready to share—I'm pregnant. In this solo episode, I'm walking you through how I found out, the emotional whirlwind that followed, and what it's been like living with a 1% chance of success. From the embryo transfer to the first ultrasounds, I'm taking you behind the scenes of the journey so far, including what I've been doing to stay grounded through it all. If you're going through something uncertain or hoping for your own miracle, I hope this conversation makes you feel a little less alone. Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Pursuit Network's Instagram click here! Sponsored By: Shop non-toxic cookware at carawayhome.com/MARI or use code MARI for 10% off. Enjoy free shipping, easy returns, and a 30-day trial. Save 15% at boncharge.com with code PURSUIT and experience science-backed beauty with the Red Light Face Mask. Get better sleep, skin & hair with Blissy. Use code POWPOD for 30% off at blissy.com/POWPOD. Start your summer side hustle with Shopify. Build your brand today at shopify.com/mari—your business, your way. Sleep better with Eight Sleep's Pod 4 Ultra. Get $350 off with code POW at eightsleep.com/pow. Get $100 toward Function Health — the most advanced at-home lab testing. First 1000 only: functionhealth.com/pow Show Links: Learn more about the Pursuit Network and how to join here Build strength, balance & self-love with The EMPWR Podcast Explore peak performance & brain health on The Neuro Experience Find joy, healing & real talk on For the Healthy Hoes Support gut health, immunity, and glowing skin with Bloom Colostrum—a 3-in-1 blend of colostrum, collagen, and probiotics. Topics Discussed 00:00:09: Welcome 00:04:51: Starting a podcast network 00:06:12: Embryo transfer 00:09:44: Two week waiting period 00:16:11: Finding out I'm pregnant 00:19:38: Low hCG 00:22:21: 1% chance of viable pregnancy 00:24:06: hCG rising 00:29:48: First ultrasound 00:32:21: Graduating from IVF clinic 00:39:09: Pregnancy symptoms 00:42:32: Exercise and nutrition
Shannon tried Fen-Phen, the Ideal Protein Diet, Noom (twice), and even did the HCG Diet w/ the HCG shots. Did she lose weight? Yes. Did she regain it? Oh yes.At one point, Shannon lost 110 pounds, was scared to even sniff a cookie, and realized she really wasn't enjoying her life at all. She said she was always trying to cram her life into some diet, all while battling anxiety, perfectionism, and people pleasing. And then she finally realized all that just wasn't working and something had to change. In this episode, Shannon shares her story and where she is now. I guarantee you'll identify with what she shares and walk away encouraged and inspired!ANTI-DIET CLASS: https://AntiDietClass.comFREE MENOPAUSE DOWNLOAD: http://coreylittlecoaching.com/menopauseTRANSFORMATION TRINITY CLASS: https://EverybodyHatesDiets.com
Karen is 65 years old and has tried justabout every diet you can think of – The Scarsdale Diet, Atkins and keto diets, Weight Watchers, Noom, the Cabbage Soup, Healthy Inspirations, grapefruit diet, Whole30, Slim-Fast, South Beach, Green Smoothie Diet, Nutrisystem, hCG – if you've heard of it, Karen probably tried it! Some of these diets brought Karen temporarysuccess, and others caused her to gain weight or slow her metabolism. None of them were sustainable, and the weightalways crept back. One day in the summer of 2020, Karen was perusing Facebook and saw a photo of her sister-in-law, Dedra Campbell. Karen thought Dedra had posted a “Throwback Thursday” photo, as her sister-in-law looked young, slim, and glowing. Karen was shocked to learn the photo was recent, so she immediately called her sister-in-law to find out what she did to lose weight and seemingly age backwards. Dedra told her the secret was IntermittentFasting brought up negative thoughts and feelings in Karen. In Karen's mind, fasting = deprivation and hunger. However, with her sister-in-law's encouragement, she listened to the basics of the program and bought the book she recommended, “Fast.Feast.Repeat.” by Gin Stephens. Karen read the book and said she would try it for one day to see how it went. On August 13, 2020, Karen did a clean 18/6 fast, found it to be effortless, and the rest, as they say, is history. Karen was invited to Graeme's group, The Fasting Highway, by Dedra after another IF guru closed her Facebook group and moved to another platform. Karen had been fasting for not quite a year when she joined The Fasting Highway. Karen had only lost 10 pounds by this time, but was encouraged and inspired by Graeme, his book, and fellow group members to stay the course and trust the process. Karen realised that her weight loss journey was her own, and she could not compare herself to others. Karen is 5'5” and her highest weight ever was 208 pounds. She could not bend over to tie her shoes at that weight and was always out of breath. She also suffered from sleep apnea. Karen's IF starting weight was 175.4 pounds, and she set her goal weight at 160 pounds (because she didn't think that at herage, being post-menopausal, having T2D, and being insulin resistant, she could get below that weight). However,on July 3, 2023, Karen weighed 149 pounds, a weight she hadn't seen in almost 20 years. Best thing – there wasno struggle to get there! Yes, it did take almost 3 years to lose the weight, but the point is – she lost it withintermittent fasting when nothing else worked! It's now been almost 5 years since Karen started intermittent fasting, and her current weight is 142 pounds. She sometimes gets as low as 138 pounds, bouncing between that number and 142 pounds. Karen went from a size 12 (US) to wearing sizes 4 and 6. Intermittent fasting gave Karen theconfidence that she would never have to lose weight again – and for the first time in years, she doesn't have 5 different clothing sizes in her closet. She donated all her “big” clothes to charity, knowing she'd never need them again. Another personal win is that Karen decidedto embrace her greys and, as a result, cut all the hair colour out. She would never have had theconfidence to do this at her higher weights!To join the Patreon Community. Please go to www.patreon.com/thefastinghighway or visit the website www.thefastinghighway.com for more information.To book a one-on-one support session with GraemePlease go to the website, click " get help" and " get coaching " to book a time .DisclaimerThe views expressed in this podcast are those of the host and guest only and should not be taken as medical advice.
In this episode, I recap the wild premiere of TLC's "PolyFamily," a closed poly quad where two couples navigate their unconventional relationships while raising kids together. I share my astonishment at the bizarre dynamics, including bedroom swapping and unexpected romantic connections between the women, and I can't help but wonder if this setup will lead to drama or harmony. I also provide an update on Meri Brown from "Sister Wives," who seems ready to move on from the show while confirming they are filming for Season 20. Additionally, I share some positive news about my own fertility journey, including my HCG levels and plans for an egg donor baby transfer this summer, reflecting on the challenges of trying to conceive at 43. Join me as I explore the chaos of reality TV and my personal life! Timestamps: 00:00:00 - Introduction to the Podcast and Sister Wives Update00:05:10 - Recap of the new TLC PolyFamily Show00:10:21 - Parenting Challenges in the Quad00:11:02 - Exploring Sexual Boundaries and Relationships00:22:20 - Meri Brown's TikTok Live Insights00:34:02 - Conclusion and Upcoming Shows Get Tickets To Our Virtual Live Podcast show May 1st at 7pm EDT. Here's the link for tickets: https://www.eventbrite.com/e/david-yontef-sarah-fraser-virtual-live-show-ask-us-anything-51-7pm-tickets-1276780297239?aff=erelexpmlt MY Go Big Podcasting Courses Are Here! Purchase Go Big Podcasting and learn to start, monetize, and grow your own podcast. USE CODE: TIKTOK20 for 20% OFF (code expires April 30th, 2025) **SHOP my Amazon Marketplace - especially if you're looking to get geared-up to start your own Podcast!!!** https://www.amazon.com/shop/thesarahfrasershow Show is sponsored by: Horizonfibroids.com get rid of those nasty fibroids Nutrafol.com use code TSFS for FREE shipping and $10 off your subscription Prolonlife.com/tsfs 15% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Nutrition Program! ● Try their detox that has REAL FOOD and WORKS! Rula.com/tsfs to get started today. That's R-U-L-A dot com slash tsfs for convenient therapy that's covered by insurance. SkylightCal.com/tsfs for $30 OFF your 15 inch calendar Quince.com/tsfs for FREE shipping on your order and 365 day returns Warbyparker.com/tsfs make an appointment at one of their 270 store locations and head to the website to try on endless pairs of glasses virtually and buy your perfect pair Follow me on Instagram/Tiktok: @thesarahfrasershow ***Visit our Sub-Reddit: reddit.com/r/thesarahfrasershow for ALL things The Sarah Fraser Show!!!*** Advertise on The Sarah Fraser Show: thesarahfrasershow@gmail.com Got a juicy gossip TIP from your favorite TLC or Bravo show? Email: thesarahfrasershow@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, I recap the wild premiere of TLC's "PolyFamily," a closed poly quad where two couples navigate their unconventional relationships while raising kids together. I share my astonishment at the bizarre dynamics, including bedroom swapping and unexpected romantic connections between the women, and I can't help but wonder if this setup will lead to drama or harmony. I also provide an update on Meri Brown from "Sister Wives," who seems ready to move on from the show while confirming they are filming for Season 20. Additionally, I share some positive news about my own fertility journey, including my HCG levels and plans for an egg donor baby transfer this summer, reflecting on the challenges of trying to conceive at 43. Join me as I explore the chaos of reality TV and my personal life! Timestamps: 00:00:00 - Introduction to the Podcast and Sister Wives Update00:05:10 - Recap of the new TLC PolyFamily Show00:10:21 - Parenting Challenges in the Quad00:11:02 - Exploring Sexual Boundaries and Relationships00:22:20 - Meri Brown's TikTok Live Insights00:34:02 - Conclusion and Upcoming Shows Get Tickets To Our Virtual Live Podcast show May 1st at 7pm EDT. Here's the link for tickets: https://www.eventbrite.com/e/david-yontef-sarah-fraser-virtual-live-show-ask-us-anything-51-7pm-tickets-1276780297239?aff=erelexpmlt MY Go Big Podcasting Courses Are Here! Purchase Go Big Podcasting and learn to start, monetize, and grow your own podcast. USE CODE: TIKTOK20 for 20% OFF (code expires April 30th, 2025) **SHOP my Amazon Marketplace - especially if you're looking to get geared-up to start your own Podcast!!!** https://www.amazon.com/shop/thesarahfrasershow Show is sponsored by: Horizonfibroids.com get rid of those nasty fibroids Nutrafol.com use code TSFS for FREE shipping and $10 off your subscription Prolonlife.com/tsfs 15% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Nutrition Program! ● Try their detox that has REAL FOOD and WORKS! Rula.com/tsfs to get started today. That's R-U-L-A dot com slash tsfs for convenient therapy that's covered by insurance. SkylightCal.com/tsfs for $30 OFF your 15 inch calendar Quince.com/tsfs for FREE shipping on your order and 365 day returns Warbyparker.com/tsfs make an appointment at one of their 270 store locations and head to the website to try on endless pairs of glasses virtually and buy your perfect pair Follow me on Instagram/Tiktok: @thesarahfrasershow ***Visit our Sub-Reddit: reddit.com/r/thesarahfrasershow for ALL things The Sarah Fraser Show!!!*** Advertise on The Sarah Fraser Show: thesarahfrasershow@gmail.com Got a juicy gossip TIP from your favorite TLC or Bravo show? Email: thesarahfrasershow@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Lots of Advanced Bodybuilding Protocols - The Steroids Podcast Episode 74#bodybuilding #TRT #Muscle #Contestprep #bodybuildingpodcastMy Book:ULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING Link - https://bodybuilderinthailand.com/ultimate-guide-to-roids/Daily Text Msg Training 99/month and 1 Hour Phone Call Consult 59 Send Email to inquire about personal training to steroidspodcast@gmail.comBodybuilder in Thailand on Instagram: https://www.instagram.com/bodybuilderinthailand/My Other Podcast: Grab the Bull Podcast:https://youtu.be/X6SzfCrN4NY?si=Ho2T9WIVxLjXo_AETABLE OF CONTENTS TIMSTAMPS:0:00 Taking 500mg testosterone enanthate per week for 2 years and now using tren 350mg4:50 Weight Lifting progression prime importance 5:52 taking 750 test e for 16 weeks and taking superdrol 30mg and getting Gyno, liquid coming out of nipples10:50 HGH and Clenbuterol and Thyroid in women and their anabolic male hormone use for gym. 16:41 Are there any stronger steroids that don't put you in a bad mental state?20:45 Deca and Primobolan Mentality23:55 Injectable Winstrol is White26:54 Does HGH always need to be kept in the Refrigerator what happens if its Left at Room Temperture28:22 Vascularity, Veins, Angiogenesis32:49 HCG and Testicle Size and Sperm35:40 PCT in the middle of a big push in bodybuilding39:11 Hypothalamic Pituitary Adrenal Axis Dysfunction - Stress Response System43:30 DHEA is this tablet needed or beneficial for TRT and STEROID USERS47:06 A Hardcore Bodybuilder using Insulin asks for Opinion53:00 Acromegaly in Bodybuilders, Details of how it develops56:26 Libido Dropped off after near the end of Tren Cycle and Coming Became ImpossibleThis Podcast is for entertainment and conversational purposes only. Serious Injury and Death can occur from utilizing chemical performance enhancement. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. The purpose of this podcast is not to glorify the use of PED's but to bring to light the reality of what athletes are doing privately. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.
In this Huberman Lab Essentials episode, I explain how to optimize hormones—particularly testosterone, estrogen, and related sex steroids—to enhance fertility and overall well-being. I discuss the sources of testosterone and estrogen and how their levels fluctuate with age in both males and females. I also cover how behaviors such as exercise, cold and heat exposure, light exposure, illness, and breathing patterns affect hormones. Additionally, I examine specific supplements and replacement therapies, highlighting important precautions to consider when adjusting hormone levels. Huberman Lab Essentials episodes are approximately 30 minutes long and focus on key scientific insights and protocol takeaways from past Huberman Lab episodes. These short episodes will be released every Thursday, while our full-length episodes will continue to be released every Monday. Read the show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Huberman Lab Essentials; Hormones 00:01:15 Testosterone & Estrogen Sources & Age, Adrenals 00:03:34 Sponsor: Eight Sleep 00:05:05 Competition, Males & Testosterone; Dopamine 00:09:27 Testosterone Decreases, Expectant Fathers, Illness 00:11:30 Sleep Apnea, Testosterone, Estrogen, Cortisol, Tool: Nasal Breathing 00:15:57 Sponsor: AG1 00:17:00 Dopamine, Cortisol, Fertility, Tool: Light Viewing Behavior 00:19:31 Heat, Cold & Hormone Levels 00:21:14 Resistance & Endurance Training, Testosterone, Tool: Exercise Order 00:23:26 Estrogen, Menopause, Hormone Therapy 00:25:07 Sponsor: Function 00:26:54 Vitamins, Opioids, Supplements, Tongkat Ali, Cancer Risk 00:31:26 Luteinizing Hormone, hCG, Fadogia Agrestis, Tool: Blood Tests 00:36:00 Recap & Key Takeaways Disclaimer & Disclosures