Dermatology Snapshots

Dermatology Snapshots is sponsored by a educational grant from Abbivie. Feedback always welcome. 1)    12 SQ-HDM SLIT for treating allergic rhinitis and allergic asthma caused by house dut mites NICE2)    Combination of Janus kinase inhibitor and biologic for recalcitrant severe atopic dermatitis3)    Demodicosis4)    Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial5)    Analysis of health outcomes in women on oral 5 alpha reductase inhibitors: a single centre retrospective cohort study6)    Paediatric Bier anaemic spots, cyanosis, and urticaria like eruption syndrome (BASCULE) in 42 patients: a peek intodysautonomia.7)     Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

Dermatology Snapshots is sponsored by a educational grant from Abbivie. Feedback always welcome. 1)    Patient satisfaction with Teledermatology; a systematic review and meta-analysis2)    Management of scabies in children under 15Kg and pregnant or breastfeeding women: recommendations supported by the Centre of Evidence of the French Society of Dermatology3)    Prevalence and clinical impact of topical corticosteroid phobia among patients with chronic hand eczema. Findings from the Danish Skin Cohort4)    Efficacy of colchicine treatment for aphthous ulcers in paediatric patients: a retrospective review5)    Assessing the efficacy of oral tranexamic acid as an adjuvant to Triple combination Topical Treatment in Melasma6)    How useful is CXR in addition to routine Quantiferon in the Detection of Latent TB prior to biologics?7)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

Dermatology Snapshots is sponsored by a educational grant from Abbivie. Feedback always welcome.   1)    Aesthetic outcomes of running subcuticular suture v horizontal mattress suture, in linear wounds on the trunk and extremeties, a randomised evaluator blinded split wound comparative effectiveness trial2)    Clinical features and diagnostic challenges of genital ulcer biopsies, a retrospective study3)    Topical immunotherapy with DPC in paediatric patients with alopecia areata, a retrospective study of 97 patients4)    Deep dive in paediatric melanoma5)    Home v office based narrow band UVB phototherapy for patients with psoriasis, LITE randomised clinical trial6)    How many is too many? A review of the significant numbers in paediatric skin lesions and their recommended evaluation. 7)    Analysis of publicly available adverse events reported for paediatric patients treated with Janus kinus inhibitors8)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

  1)    Combination therapy with imiquimod and 5 fluorouracil cream for the treatment of AK, a prospective open-label non-randomised uncontrolled pilot trial2)    Association between dermatology follow-up and melanoma survival: a population based cohort studty3)    Dupilumab therapy for atopic dermatitis is associated with an increased risk of cutaneous T cell lymphoma; a retrospective cohort study4)    Lessons from a scoping review: clinical presentations of central centrifugal cicatricial alopecia5)    Dutasteride in the treatment of frontal fibrosing alopecia: systematic review and meta-analysis6)    Paediatric-onset lymphomatoid papulosis: results of a multi-centre retrospective cohort study on behalf of the EORTC Cutaneous Lymphoma Tumours Group CLTG. 7)    PAMI syndrome8)    Shorts (ILVEN needs genotyping, Onychopapillomas and BAP1 tumour predisposition syndrome, SKINTED)9)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles 

1)    Semaglutide for weight loss in obese patients as an adjunctive treatment for HS: its impact on disease control and quality of life2)    Deep dive on IgA Vasculitis3)    Improved clinical effectiveness of adalimumab when initiated with clindamycin and rifampicin in HS4)    Does PRP treatment really work5)    Topical steroid withdrawal: a survey of UK dermatologists attitudes6)    MHRA update on labelling of topical steroids with warnings 7)    Clinical outcomes and management of JAK inhibitor associated acne in patients with moderate to severe atopic dermatitis undergoing upadacitinib: a multicentre retrospective study8)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1)    Comparison of topical permethrin 5% v benzyl benzoate 25% treatment in scabies a double blinded randomised controlled trial2)    Ask an expert: Dr Claire Fuller3)    The Art of communicating risk and benefit to promote shared decision making, informed by behavioural economic principles4)    Exploration of the optimal time to discontinue propranolol treatment in infantile haemangiomas: a prospective study5)    Discontinuation of anti TNF treatment due to blood test abnormalities and cost effectiveness of alternative blood monitoring strategies6)    Acne keloidalis nuchae: and international multi-centric review of 79 patients.7)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

 1)    Factors associated with early onset androgenetic alopecia: a scoping review2)    Results of a treatment algorithm for generalised granuloma annulare3)    Post-inflammatory hyperpigmentation: A systematic review of treatment outcomes4)    Nice updates: difelikefalin and ritlecitinib5)    Anti-SS-A antibody is a potential predictor of severe SJS and TEN: a retrospective cohort study6)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

 1)    Risk of paradoxical eczema in patient receiving Biologics for eczema2)    Surgical excision verses topical 5% 5 fluorouracil and PDT therapy in the treatment of Bowen's disease3)    Using UV light in diagnosing scabies: Scabies sign via Wood's light.4)    Bridging the gap in BASCULE syndrome. A retrospective cases series of a recently described clinical entity. 5)    Natural language processing to automate a web-based model of care and modernize skin cancer MDT meetings6)    Staphylococcus aureus induced drug resistance in cancer T cells in Sezary syndrome7)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1)    Report of the commission on human medicines isotretinoin implementation advisory expert working group2)    2023 ACR/ EULAR antiphospholipid syndrome classification criteria3)    Adalimumab in conjunction with surgery compared with adalimumab monotherapy: a randomised control trial in a real world setting4)    Elevated risk of visceral malignant neoplasms in extramammary Paget Disease. 5)    Clinical characteristics associated with musculoskeletal extracutaneous manifestations in pediatric and adult morphea: a prospective cohort study.6)    Exposure to biologic therapy before and during pregnancy in patients with psoriasis: systematic review and meta-analysis7)    Prognostic significance of incipient ulceration in primary cutaneous melanoma8)    Sclerema neonatorum9)    Intravascular large B cell lymphoma10) Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade. Microwave energy devices for hyperhidrosis are associated with infections, neurologic symptoms and burns in a retrospective analysis of the Manufacturer and User Facility Device Experience Database 2013- 2022.11) Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1)    Real world implementation and outcomes of adalimumab therapeutic drug monitoring in psoriasis: a national specialised centre experience2)    Epidemiology and diagnostic classification of adults presenting with leukocytoclastic vasculitis: a multi-centre review of 440 patients3)    The implications of a Dermatopathologist's report on melanoma diagnosis and treatment4)    Disabling pansclerotic morphea and STAT45)    Trichodysplasia spinulosa: what is it?6)    The long term safety of topical corticosteroids in atopic dermatitis: a systematic review7)    Martha's rule: what could the proposed rule mean for doctors?8)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1)    JAK inhibitors and the risk of malignancy: a meta-analysis across disease indications.2)    Prognostic factors for long-term aesthetic outcomes of infantile haemangioma treated with beta-blockers.3)    Topical Steroid Withdrawal. What do we know about this growing problem.4)    Is methotrexate safe for men with immune mediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX)5)    Prurigo pigmentosa: a multi institutional retrospective study6)    Sucidal behaviour in psychodermatology patients: identifying characteristics and a new model for referral.7)    Why Nigeria has declared skin lightening a health emergency8)    JRobert Oppenheimer and the social responsibility of science9)    Profiling UK injectable aesthetic practitioners: a national cohort analysis10) Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

In this issue:Spironolactone for acne - does it work?Paroxetine for erythema of rosaceaMethotrexate monitoring schedules - should we rethink 3 monthly bloods?Long-term neurocognitive affects of propranololNICE eczema updateWhat's Multinucleate Cell Angiohistiocytoma?+ more…

Surgical delay for invasive melanoma - what's the impact? Subcutaneous fat necrosis of newborn Microsurgery for lymphoedema- is it safe? Facial atopic eczema and food allergyWhat's Yao Syndrome?+ More

Dupilumab and eye disease - incidence and managementRisk factors for progression from DLE to SLEIsotretinoin and IBD risk - what's the risk?Outcomes of MELTUMP and SAMPUSAtrophic papulosis - features The case for digital minimalism+ More…

Methotrexate- does it cause liver fibrosis?Bowen's disease- updated management guidelinesVitamin D for Toxic Erythema of ChemotherapyEPP- focusing on the presentationJAK inhibitors- what's the cardiac and VTE risk?Looking after our own...

Which second line treatment is best for scabies?Can we stop Ustekinumab in responders?Are bloods needed in FPHL?What is mid-childhood acne?Sentinel node biopsy in T1a melanoma, what does it add?Skin signs in catastrophic antiphospholipid syndrome

1 Facial erythema in patients with atopic dermatitis treated with Dupilumab- a descriptive study of morphology and aetiology2 The need for potassium monitoring in women on spironolactone for dermatologic conditions3 Tacrolimus “swish and spit” for complex aphthosis: outcomes in 21 patients4 Increasing prevalence of ANA in the US5 Cutaneous polyarteritis nodosa diagnosis and treatment: retrospective case series6 Cutaneous manifestations of monogenic auto-inflammatory diseases: an international cohort study from the juvenile inflammatory rheumatism cohort7 Measuring atopic eczema control and itch intensity in clinical practice a consensus statement from the harmonising outcome measures for eczema in clinical practice (HOME-CP) initiative8 Apremilast in recalcitrant cutaneous dermatomyositis: a non-randomised controlled trial9 Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1 Delays in the surgical treatment of melanoma are associated with worsened overall and melanoma specific mortality: a population based analysis2 Drug survival with effectiveness and safety of treatment with guselkumab, ixekizumab, secukinumab, ustekinumab and adalimumab in patients with psoriasis3 Sudden conjunctivitis, lymphopenia, and rash combined with haemodynamic changes (SCORCH) after trimethoprim-sulfamethoxazole use: a case series study of a hypersensitivity reaction4 Patch testing in fixed drug eruptions: a 12 year retrospective study 5 Neo-adjuvent Cemiplimab for Stage II to IV cutaneous squamous cell carcinoma6 2 Phase 3 randomised controlled trials of Ruxolitinib cream for vitiligo 7 NICE guidelines for pembrolizumab for resected stage 2B or 2C melanoma8 Trial of intravenous immunoglobulin in dermatomyositis9 Reflective case history-St George's hospital records10 Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1 Melanoma with peripheral globules: clinical and dermoscopic features2 Adalimumab with methotrexate vs adalimumab monotherapy in psoriasis: first year results of a single blind study3 Cross-sectional characteristics of paediatric-onset discoid lupus erythematosus: results of a multicentre, retrospective cohort study4 Association of risk of incident venous thromoboembolism with atopic dermatitis and treatment with janus kinase inhibitors: a systematic review and meta-analysis5 Reducing NHS outpatient followup activity by 25%: can it be done in dermatology?6 Red scrotum syndrome: an update on clinicopathologic features, pathogenesis, diagnosis and management7 Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

 1 Short courses of ciclosporin can induce long remissions in chronic spontaneous urticaria2 Isotretinoin laboratory monitoring in acne treatment- a Delphi consensus3 Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study4 Clinical features and natural course of paediatric longitudinal melanonychia: a retrospective cohort study in Korea5 The association between frontal fibrosing alopecia, sunscreens and moisturizers: a systematic review and meta-analysis6 What exactly are odds ratios?7 Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

Efficacy and safety of abrocitinib versus dupilumab in adults with moderate to severe atopic dermatitis: a randomised, double blind, multicentre phase 3 trial2021 Guidelines for the management of vulval conditionsNICE 2022 update melanoma:assessment and managementYet another NHS restructurePhysicians spreading misinformation on social media-do right and wrong answers still exist in medicine?Trial of anti BDCA2 antibody litifilimab for cutaneous lupus erythematosusEvidence of N-acetyl cysteine efficacy for skin picking disorder: a retrospective cohort studyRisk factors for complicated MOHS surgery in the South Sweden cohortIsla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles

1 Real life impact of immunologic tests to predict relapse after treatment cessation in patients with bullous pemphigoid: a French multicentre retrospective study2 Comparison on permethrin based treatment strategies against scabies in infants and young children3 Adjuvant radiotherapy may not significantly change outcomes in high risk squamous cell carcinoma with a clear surgical margins: a systematic review and meta-analysis4 Risk of invasive SCC after treatment of actinic keratosis: a secondary analysis of a RCT trial data5 Pausing methotrexate improves immunogenicity of COVID-19 vaccination in elderly patients with rheumatic disease6 Clinicoprognostic implications of head and neck involvement by mycosis fungoides: a retrospective cohort study7 Treatments and outcomes of generalised pustular psoriasis: a cohort of 1516 patients in a nationwide inpatient database in Japan.8 NICE: Abrocitinib, Tralokinumab, or Upacitinib for treating moderate to severe atopic dermatitis9 Inhibition of TNF improves conventional steroid therapy for SJS/ TEN in a cohort of patients10 Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles.

1)    Paediatric mycosis fungoides-characteristics, management and outcomes with particular focus on the folliculotrophic variant2)    Topical imiquimod verses surgery for vulval intraepithelial neoplasia: a multicentre, randomised, phase 3, non-inferiority trial3)    Longtitudinal atopic dermatitis endotypes: an atopic march paradigm that includes black children4)    Cutaneous polyarteritis nodosum diagnosis and treatment: a retrospective case series5)    Secukinumab dosing every 2 weeks demonstrated superior efficacy compared to dosing every 4 weeks in patients with psoriasis weighing 90Kg or more: results of a randomised controlled trial6)    Open notes and dermatopathology reports: a pathway to increasing patient autonomy, not confusion7)    Isla Galpin. Violin Sonata in G minor, 1st and 2nd movement by Eccles.

 1 Association of spironolactone use with risk of cancer: systematic review and meta-analysis2 British association of dermatologists guidelines for the management of people with chronic urticaria3 Focus on oral minoxidil for androgenetic alopecia and alopecia areata4 Evidence check: How long to leave between stopping tetracyclines and starting isotretinoin?5 Monkeypox goes global: why scientists are on alert6 Birth outcomes in women who have taken hydroxychloroquine during pregnancy: a prespective cohort study7 Dermatological guidelines for monitoring methotrexate treatment reduce drug survival compared to rheumatological guidelines8 Advanced Strings, Sir William Perkins's school - Isla Galpin (1st violin), Hayun Lee (2nd violin), Miss Townsend (viola), Amélie Christian (cello) - Chanson de Matin by Edward Elgar (1857–1934)

  Assessment of the diagnostic accuracy of baseline clinical examination and ultrasonographic imaging for the detection of lymph node metastasis in patients with high risk cutaneous squamous cell carcinoma of the head and neck. Efficacy of treatments for cholestatic pruritus: a systemic review and meta-analysis. Efficacy and safety profile of oral spironolactone use for androgenic alopecia: a systematic review. Lack of association of atopic dermatitis severity and worsening during pregnancy: a cross sectional study. Tofacitinib as a treatment for refractory dermatomyositis: a retrospective study from 2 academic medical centres. Superficial basal cell carcinoma., think deeper: Step sectioning of skin biopsy specimens yields 14% more aggressive subtypes. Food anaphylaxis in the UK: Analysis of national data 1998 to 2018. Budesonide capsules for peristomal pyoderma gangrenosum. COVID perniosis-a true phenomenon? Advanced Strings, Sir William Perkins's school - Isla Galpin (1st violin), Hayun Lee (2nd violin), Miss Townsend (viola), Amélie Christian (cello) - Chanson de Matin by Edward Elgar (1857–1934)

 1)    Adverse pregnancy and maternal outcomes in women with hidradenitis suppurativa2)    Infections in children and adolescents treated with Dupilumab in paediatric clinical trials for atopic dermatitis-a pooled analysis of the trial data3)    Biological disease modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis4)    The spread of resistant tinea and the ingredients of a perfect storm5)    Asynchronous telemedicine for isotretinoin management: a direct care pilot6)    BAD guidelines for the management on people with vitiligo 20217)    Facial discoid dermatosis8)    Timing of introduction to solid food, growth and nutrition risk in later childhood

 1)    Effect of therapeutic drug monitoring verses standard therapy during maintenance infliximab therapy2)    Dupilumab in children with uncontrolled moderate-to-severe asthma3)    Fibrosing alopecia in a pattern distribution 4)    Multi-state model for predicting ocular progression in Acute Stevens-Johnson syndrome/ Toxic Epidermal necrolysis5)    Specific features of amoxicillin-associated Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: a nationwide study6)    Phase 3 Trials of Tapinarof cream for Plaque Psoriasis7)    Trial of Spesolimab for Generalised  Pustular Psoriasis8)    Deficiency of adenosine deaminase 2: updates on the phenotype, genetics, pathogenesis and treatment9)    Amazon Care has launched in the US, we speculate that a UK launch is not too far away…10) Advanced Strings, Sir William Perkins's school - Isla Galpin (1st violin), Hayun Lee (2nd violin), Miss Townsend (viola), Amélie Christian (cello) - Chanson de Matin by Edward Elgar (1857–1934)

What's new in the updated BCC guidelines? Lupus anticoagulant single positivity during the acute phase of COVID-19 is not associated with venous thromboembolism or in-hospital mortality. Purpura as an indicator of severity in Drug-induced Hypersensitivity Syndrome/ DRESS Electrocardiogram as a Lyme disease screening test. Prevalence of mastocytosis and hymenoptera venom allergy in the United States. Evaluation of thalidomide treatment of patients with chronic Erythema Multiforme. VEXAS-Clinical presentation of a newly described somatic, auto-inflammatory syndrome. Should all babies have their genome sequenced at birth? Measles outbreaks likely as COVID pandemic leaves millions of world's children unvaccinated, WHO warns. Advanced Strings, Sir William Perkins's school- Isla Galpin (1st violin), Hayun Lee (2nd violin), Miss Townsend (viola), Amélie Christian (cello) - Chanson de Matin by Edward Elgar (1857–1934)

Edited by Drs L Ferguson and Z Jiyad.Narrated by Dr V Pinder.1) Evaluation of watchful waiting and tumour behaviour in patients with BCC2) Methotrexate hampers immunogenicity to BNT162B2 MRNA COVID vaccine in immune mediated inflammatory disease3) Diagnostic utility of circumferential peripheral globules under dermoscopy in adults4) The safety and immunologic effectiveness of live varicella zoster vaccine in patients receiving anti-TNF inhibitor therapy5) A systematic review of the impact of genetic testing for familial melanoma i) primary and secondary preventative behaviours ii) psychosocial outcomes and attitudes6) Skin adverse events related to PPE: a systematic review and meta-analysis7) Cutaneous findings in Fanconi's anaemia8) Adenopathy and extensive skin patch overlying plasmocytoma (AESOP): 2 morphological variants.Advanced Strings, Sir William Perkin's school- Isla Galpin (1st violin), Hayun Lee (2nd violin), Miss Townsend (viola), Amélie Christian (cello) - Chanson de Matin by Edward Elgar (1857–1934)