Podcasts about platelets

Component of blood aiding in coagulation

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Best podcasts about platelets

Latest podcast episodes about platelets

Blood Podcast
Stratifying risk in acute myeloid leukemia, daratumumab plus chemotherapy in relapsed-refractory pediatric leukemias, and a method for creating genetically engineered platelets

Blood Podcast

Play Episode Listen Later Nov 21, 2024 17:49


In this week's episode we'll learn more about a new risk classification scheme for use in patients with acute myeloid leukemia who are ineligible for intensive therapy, efficacy and safety of daratumumab plus chemotherapy in pediatric patients with acute lymphoblastic leukemia or lymphoblastic lymphoma, and a blood bank-compatible method for creating genetically engineered platelets with a wide range of potential uses.Featured Articles:Genetic Risk Stratification and Outcomes Among Treatment-Naive Patients with AML Treated With Venetoclax and Azacitidine Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: DELPHINUS Study Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices  

NP Certification Q&A
Elevated BP In Pregnancy

NP Certification Q&A

Play Episode Listen Later Nov 4, 2024 8:51


A 25-year-old woman gravida 2, para 1 is 24 weeks pregnant and is being seen for an urgent care visit. She reports a constant headache over the past two days along with ankle swelling. Her BP today is 162/86 in, which is a significant elevation from her pre pregnancy blood pressure of 122/68.Laboratory results indicate 2 plus proteinuria as well as elevated ALT and AST. Platelets and LDH are within normal limits, as is fundoscopic and neurological exams. The most likely diagnosis is: A. Health syndromeB. Gestational hypertensionC. PreeclampsiaD. Hypertensive emergencyVisit fhea.com to learn more!

Hipster Baseball Podcast
171 - Marco LaNave

Hipster Baseball Podcast

Play Episode Listen Later Oct 27, 2024 41:25


We may not have to listen to “Even Flow” by Pearl Jam at Dodger Stadium, and Juan Soto may not want to re-sign with the NY Yankees after watching Aaron Judge and the NY Yankees struggle in the playoffs; and (4:11) Marco LaNave, Broadcaster & Front Office Staff Member for the Akron Rubber Ducks, talks Astrophysical Plasma, Cleveland Guardians, and donating Platelets. Drink: Cruzan (Single Barrel) Premium Extra Aged Rum from St Croix, US Virgin Islands Akron Rubber Ducks website: https://www.milb.com/akron/ballpark/front-office Marco's Twitter: https://x.com/LaNaveMarco Marco's Instagram: https://www.instagram.com/lanavemarco/ Last Call Baseball T-Shirts: https://lastcallbaseball.creator-spring.com/ Last Call Baseball Instagram: https://www.instagram.com/lastcallbaseball/ Last Call Baseball Twitter: https://x.com/LastCall4040 Intro and Outro Music: DeCarlo Podcast Logo Artist Instagram: https://www.instagram.com/regan_vasconcellos/

SBS Tamil - SBS தமிழ்
ஆஸ்திரேலியாவில் பெண்கள் ஏன் platelets தானம் செய்ய முடியாது?

SBS Tamil - SBS தமிழ்

Play Episode Listen Later Oct 16, 2024 10:43


ஆஸ்திரேலியாவில் எப்போதும் இல்லாத அளவு இப்போது இரத்த வங்கிகளில் Platelets கையிருப்பில் பற்றாக்குறை நிலவுவதாக கூறப்படுகிறது. அதற்கான காரணம் என்ன மேலும் இரத்த தானம் செய்வது பற்றிய பல கேள்விகளுக்கு பதில் அளிக்கிறார் Royal North Shore மருத்துவமனையில் Haematologist-ஆக பணியாற்றும் டாக்டர் பூமகள் குமார் அவர்கள். அவரோடு உரையாடுகிறார் செல்வி.

Medical Nursing Podcast | CPD for Veterinary Nurses
42 | Help, my patient has no platelets! How to care for thrombocytopenic patients

Medical Nursing Podcast | CPD for Veterinary Nurses

Play Episode Listen Later Sep 27, 2024 16:59


Picture this. You're working the Saturday morning shift, you're wrapping things up ready to close, and your vet brings through a patient from consults. The patient is a 6-year-old cocker spaniel, and they've got a history of lethargy and exercise intolerance, progressing to melena, haematuria and bruising in the last 2 days. You examine them with the vet and find they're dull, tachycardic and have bounding pulses. What's going on, and most importantly, what are you going to do about it? Well - they have some kind of bleeding disorder, and based on these signs, there's a good chance they have very low platelet levels.  But why does this happen, and how can we support these patients? We'll dive into all of that in this episode. ---

NB Hot Topics Podcast
S6 E1: SGLT2i & Dementia; De-Escalating Anti-Platelets Post-MI; RSV Vaccination

NB Hot Topics Podcast

Play Episode Listen Later Sep 6, 2024 15:51


Welcome to Season 6 of the Hot Topics podcast with Dr Neal Tucker. The summer holidays are over and it's back to work so time for a new podcast. In this episode, we look at research on whether SGLT2i might prevent dementia, on if it is safer to de-escalate sooner rather than later from dual anti-platelet therapy post-MI, and how effective is the new RSV vaccine at preventing hospitalisation in older people.ReferencesBMJ - SGLT2i & dementiaLancet - De-escalation of DAPT post-MIJAMA - RSV Vaccination Efficacy in Older Peoplewww.nbmedical.com/podcast

Blood Podcast
TCR-T cells for post-HCT leukemia recurrence; platelets are the predominant source of procoagulant membranes in hemostasis; BR + R maintenance for MCL

Blood Podcast

Play Episode Listen Later Sep 5, 2024 18:10


In this week's episode we'll discuss HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation. Next, we'll learn about how 4D intravital imaging in mice reveals the key role of platelets as a source of procoagulant membranes in hemostasis. Finally, we'll hear about modifications to a common induction and maintenance treatment for treatment-naïve mantle-cell lymphoma.Featured ArticlesHA-1–targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem celltransplantation4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mousehemostasis modelRandomized study of induction with bendamustine-rituximab ± bortezomib and maintenance withrituximab ± lenalidomide for MCL

Kids Learning Lab!
All about your Bloodstream (Includes Transcript)

Kids Learning Lab!

Play Episode Listen Later Aug 24, 2024 4:13


We've launched Patreon, a service that lets you get paid subscriptions, free subscriptions, and give donations. Check it out today, with a 7-day free trial! In this episode, we'll be talking about the bloodstream. DISCLAIMER: THIS EPISODE IS NOT SCARY, JUST INFORMATIVE. IF YOU DON'T WANT TO LISTEN TO THIS EPISODE, YOU DON'T HAVE TO. Transcript (straight from my own script): All About the Bloodstream Kids Learning Lab! [INTRO] Edited using Audacity, a free, open-source audio editor. Reminder: This episode is not scary. It is just informational. [TRANSITION] Hello! Before we start this episode, I'd like to tell you about the free games on the Kids Learning Lab website. There are 2 games, one about our episode on Chocolate, and another about our Dinosaurs episode. Also, you can sign up for the Kids Learning Lab newsletter to get quizzes, fun facts, and free bonus content. The newsletter is absolutely free and you can sign up on Patreon. Also, about Patreon. It's a service where you can sign up for free subscriptions, donate to Kids Learning Lab, and buy paid subscriptions that include bonus content, such as shout-outs, videos from me personally, and extra episodes and behind-the-scenes videos. Check it out today! Now, time for this episode. In this episode, we're going to talk about the bloodstream, or as some call it, the circulatory system. [TRANSITION-2] Your heart is like the engine of your circulatory system. Your heart pumps blood through small rivers called arteries and veins. Your muscles need oxygen. Blood is like a shipping container that holds oxygen. Arteries go from your lungs to your muscles. Arteries bring blood that has oxygen to your muscles. Muscles trade blood for carbon dioxide. That's why you breathe oxygen and exhale carbon dioxide! [short pause] Veins take the carbon dioxide blood and bring it to your lungs. The heart powers all of this by pumping the blood. When veins with empty blood reach the lungs, the lungs give oxygen to the blood. Then, the blood travels through arteries since they have oxygen. Now, let's talk about blood cells. Red blood cells are the shipping containers. They contain oxygen. White blood cells are the body's army. They eat up any viruses or sicknesses in your blood. The reason you cough and get a fever is the result of the white blood cells fighting. Platelets are little cells that act like band-aids. Have you ever gotten hurt and then the spot dried up? That is a scab. Scabs contain platelets. The platelets cover up the spot so viruses and diseases can't get it. It's like when the walls of your body's castle breaks because of an injury, the soldiers quickly put up a wall. Platelets are the bricks the soldiers use to cover up the hole. Time for fun facts! 1. Throughout your life, your heart will probably pump 2.5 billion times! 2. If the blood cells in your blood were stacked one on top of another, it would reach 12% to the moon! That's 6,200 times the height of Mount Everest and 516 times the distance to space. 3. Bones make blood! 4. Your bloodstream is 60,000 miles long! That's 1/4 of the way to the moon! Thanks for listening! I hope you enjoyed this episode. The next one is going to be about the Olympics! [END SCRIPT]

The Andrew Carter Podcast
Caring for Kids Radiothon: Maya's story

The Andrew Carter Podcast

Play Episode Listen Later Aug 22, 2024 4:04


When Maya was 2 years old, her mom Melanie took her to the pediatrician because she had fever and spots on her face. After a blood test, it was discovered that Maya's platelets were low. It wasn't leukemia, Maya has an autoimmune disorder called ITP. Melanie spoke with Ken Connors.  

Evidence Based Birth®
EBB 323 - Q & A on Frequent Air Travel in Pregnancy, Induction for Low Platelets, and Anterior vs. Posterior Placenta

Evidence Based Birth®

Play Episode Listen Later Aug 14, 2024 40:24


In today's episode, we're diving into a mini Q&A session to address some pressing questions from our incredible EBB Pro Members. We'll explore the risks of radiation exposure during air travel in pregnancy, particularly for airline crew members. Then, we'll discuss the implications of low platelet counts and whether they necessitate induction. Lastly, we'll look at new research on the location of the placenta—whether anterior, posterior or lateral—and its impact on birth experiences. Tune in for evidence-based answers on these important topics! View the full list of references for this episode here. For more information about Evidence Based Birth® and a crash course on evidence based care, visit www.ebbirth.com. Follow us on Instagram, YouTube, and TikTok! Ready to learn more? Grab an EBB Podcast Listening Guide or read Dr. Dekker's book, "Babies Are Not Pizzas: They're Born, Not Delivered!" If you want to get involved at EBB, join our Professional membership (scholarship options available) and get on the wait list for our EBB Instructor program. Find an EBB Instructor here, and click here to learn more about the EBB Childbirth Class.

ReachMD CME
Case Discussion: What JAK Inhibitor Should I Use in a Transfusion-Dependent Patient With MF With Platelets > 50 × 109/L?

ReachMD CME

Play Episode Listen Later Jul 19, 2024


CME credits: 1.00 Valid until: 19-07-2025 Claim your CME credit at https://reachmd.com/programs/cme/case-discussion-what-jak-inhibitor-should-i-use-in-a-transfusion-dependent-patient-with-mf-with-platelets-50-109l/26512/ Primary myelofibrosis is a complex disease requiring precise treatment strategies. Effective selection and sequencing of JAK inhibitors, particularly for cytopenic myelofibrosis, can significantly improve patient outcomes. Stay informed on managing ruxolitinib intolerance and recognizing a failure to optimize therapeutic results so that you can enhance care for your patients. Please stay tuned for additional content to this program available for credit. The maximum amount of credits available for the entire activity is 1.0.

Rheuminations
NSAIDs, Part 2: The Dawn of the Anti-Inflammatories

Rheuminations

Play Episode Listen Later Jun 26, 2024 46:59


In this episode, we dive into the story of aspirin and the development of ibuprofen, ending with the experiments that showed the mechanism of how aspirin actually works. Intro 0:12 Review of part 1 0:28 In this episode 1:04 Blocking prostaglandins and willow leaves 2:26 Edward Stone 3:45 Johann Andreas Buchner 4:16 The chemical structure of salicylic acid and creating the synthetic compound 4:44 Dr. TJ MacLagan: The first trial in 1876 and treating acute rheumatism 5:16 Felix Hoffmann: manipulating salicylic acid and aspirin 8:47 How widespread was the use of aspirin for rheumatoid arthritis? 12:04 1938: problems with aspirin and endoscopies 14:58 1950s: long-term use of aspirin and chronic renal impairment 17:12 Dr. Lawrence Craven: the use of aspirin to treat myocardial infarction 18:13 Overview of what we've learned so far 20:48 Stewart Adams: the development of ibuprofen 21:40 A paper lost to time 23:29 How do you test if a drug is anti-inflammatory? 25:25 How do you make better aspirin? 26:55 1960: a trial comparing ibuprofen, baby aspirin and prednisone in patients with rheumatoid arthritis 30:03 Aspirin, ibuprofen and other NSAIDs 32:49 Nobel Prize winner Dr. John Vane 33:40 Dr. Vane: what triggered prostaglandin production? 35:42 Another guinea pig experiment 37:37 Nobel Prize winner Dr. Bengt Samuelsson 39:00 Interesting tidbits: early studies looking at the side effects of NSAIDs 40:01 1968: gastric ulcer formation and prostaglandins in rats 40:25 1973: renal blood flow and prostaglandins in dogs 41:53 1974: aspirin vs ibuprofen vs indomethacin for the heart 44:03 Aspirin vs ibuprofen vs indomethacin 44:20 On the next episode 46:09 Thanks for listening 46:37 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Adams SS. Inflammopharmacology. 1999;doi:10.1007/s10787-999-0002-3. https://www.aspirin-foundation.com/history/the-aspirin-story/. Buchanan WW, et al. J Rheumatol. 2002;29(6):1321-3. Cryer B, et al. Gastroenterology. 1999;doi:10.1016/s0016-5085(99)70545-7. Desborough MJR, et al. Br J Haematol. 2017;doi:10.1111/bjh.14520. Halford GM, et al. Platelets. 2012;doi:10.3109/09537104.2011.632032. Harris SC, Fosdick LS. Theoretical considerations of the mechanisms of antipyretic analgesia. NWU Bull. 1952;53: 6–9. Jasani MK, et al. Ann Rheum Dis. 1968;doi:10.1136/ard.27.5.457. Robert A, et al. Gastroenterology. 1968;55(4):481-7. Disclosures: Brown reports no relevant financial disclosures.

The CIRS Group Podcast
Do you pee too much? More than 4 times a day might mean CIRS! CIRSx 2024 Recap

The CIRS Group Podcast

Play Episode Listen Later Jun 26, 2024 24:41


For more information, visit https://thecirsgroup.com   CIRS, or Chronic Inflammatory Response Syndrome, is a complicated illness that we strive to demystify for you here, every week on The CIRS Group Podcast. This week we will be concluding our fun CIRSx 2024 recap series - and we've saved some of the heaviest talks for last! Today we're covering Histamine/MAST cell reactivity, the dangers of consuming seed oils, Hyperbaric Oxygen Chamber Therapy, and ADH/Osmolality issues (peeing too much!). We heard some great talks by Dr. Louise Carder, Dr. McMahon, and more - so check out today's episode to learn our big takeaways from these great talks. For more information, support, and resources in your own CIRS healing journey, visit TheCIRSGroup.com   TIME STAMPS: 0:00 Intro and disclaimer 1:12 Dr. Louise Carder's talk on Histamines 3:26 Important takeaways about histamines 4:35 Things you can do if you struggle with histamines 6:00 Histamine support can cause better MSH levels 7:02 Dr. Knobbe's Seed Oils talk 9:20 Dr. Jim Ryan's talk about platelets 11:30 Platelets activate differently with CIRS 12:42 Dr. Meyers' talk on Hyperbaric Chamber Treatment 15:20 Takeaways from this talk: MARCoNs, mitochondrial function, inflammatory markers 16:10 Pressure matters: what Dr. Meyers recommends 18:22 Dr. McMahon's talk on ADH: Pee all that you can pee 19:25 How to tell if you're peeing too much 21:50 Kids and bed-wetting 22:39 How to correct ADH/Osmolality issues 24:03 Why The CIRS Group is great (no, really!) HELPFUL LINKS: Dr. Louise Carder's website: https://www.louisecarder.com/ Dr. Chris Knobbe's book, The Ancestral Diet Revolution: How Vegetable Oils and Processed Foods Destroy Our Health - and How to Recover! https://a.co/d/79KIEEY Dr. Jim Ryan's website: https://www.progenedx.com/ Dr. Ryan Meyers' clinic website: https://www.themovement.clinic/ Dr. Ryan Meyers' instagram: https://www.instagram.com/docryanmeyers/ US Hyberbarics: https://www.ushyperbarics.co/ Dr. McMahon's website: https://scottmcmahon.doctor/   The CIRS Group: Support Community: https://thecirsgroup.com Instagram: https://www.instagram.com/thecirsgroup/   Find Jacie for carnivore, lifestyle and limbic resources: Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Limbic Training Community: https://www.wired4healing.com   Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a 4 year carnivore, certified nutrition coach, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a coach, facilitator, speaker, 3 year carnivore, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

Cupcakes At A Funeral
Cupcakes at a Funeral S4 EP 12: Cal finally saw Megan Thee Stallion, Tifah's Platelets are still Low, more updates and DE CENTER MEN!!!!

Cupcakes At A Funeral

Play Episode Listen Later Jun 17, 2024 73:33


ummmmm.... so we are back from a month of no recording... BUT we come back with updates! - Cal saw meg! - Tifah encounters a Hotep - FAT VEGAN - DECENTERING MEN - More Wedding stuff

Acute Medicine Podcast - SAM
Low Platelets - Interview with an Expert

Acute Medicine Podcast - SAM

Play Episode Listen Later Jun 17, 2024 53:59


This episode sees Vicky chatting to a Haematologist about low platelets, what do we need to think about, investigate and manage.

platelets haematologist
JIJI English News-時事通信英語ニュース-
Team Develops Equipment to Make More iPS Cell-Derived Platelets

JIJI English News-時事通信英語ニュース-

Play Episode Listen Later Jun 17, 2024 0:13


A team including Kyoto University researchers has developed equipment capable of producing five times more platelets derived from induced pluripotent stem, or iPS, cells than existing apparatus.

WIRED Science: Space, Health, Biotech, and More
These Artificial Blood Platelets Could One Day Save Lives

WIRED Science: Space, Health, Biotech, and More

Play Episode Listen Later May 14, 2024 8:00


Platelets help blood clot, but they have a short shelf life. With blood in short supply, synthetic platelets could help meet demand. Learn more about your ad choices. Visit podcastchoices.com/adchoices

TRANSFUSION's Monthly Podcast
March podcast - RCT of riboflavin/UV-treated platelets

TRANSFUSION's Monthly Podcast

Play Episode Listen Later May 10, 2024 29:11


March podcast - RCT of riboflavin/UV-treated platelets by TRANSFUSION's Monthly Podcast

Mayo Clinic Talks
Lab Medicine Edition | CBC: Platelets (Thrombocytosis, Thrombocytopenia)

Mayo Clinic Talks

Play Episode Listen Later May 9, 2024 30:22


HOST: Andy Herber, P.A.-C. GUEST: Ronald S. Go, M.D. Join our host, Andy J. Herber, P.A.-C., as he discusses the complete blood count (CBC), which is one of the most ordered laboratory tests in the primary care setting. Providers are frequently tasked with evaluating all aspects of the CBC. A keen understanding of this laboratory test is essential to providing quality care for patients. Ronald S. Go, M.D. returns as a guest to discuss abnormal platelet test results and its implication on patient management. Learn more about our Lab Medicine Edition here Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Why Struggle? Podcast w Barbara J. Faison
2024 - Week 17 - Pinochle, Platelets and Resident Alien

Why Struggle? Podcast w Barbara J. Faison

Play Episode Listen Later Apr 24, 2024 7:23


2024 - Week 17 - Pinochle, Platelets and Resident Alien All the links: Linktr.ee/barbarafaison Doing new things is great for your brain. I am an LL- a lifelong learner and I'm grateful that for the most part I enjoy trying new things. I've been doing new things so long it really is second nature for me, most of the time. Watching a genre of a movie or a series you normally wouldn't watch is doing something new. It can also be picking up something new when you go grocery shopping or turning down a different street on your way home. It doesn't have to be major, just something “different” from the usual. This week I did three new things: Pinochle, donated platelets and watched Resident Alien on Netflix. Pinochle Last weekend I went over to my friend Kym Kennedy's house for a birthday celebration. At these gatherings, we pretty much hang out for the day. It's always a lot of fun and people come and go based on their availability. I arrived mid afternoon after a four hour shift working at the local library. We offer passport processing at our branch and Saturday is usually very busy. I was looking forward to it and relaxing. After greeting the ladies that were there, I grabbed a plate of food and sat down to join the festivities. We laughed and talked, and then started to play cards. I grew up playing cards which included tonk, bid, whist, gin rummy, spades to name a few. The card game they started to play was pinochle. I don't recall ever playing pinochle. I was up for something new. Why not? When the ladies started to explain the game and pulled out a piece of paper to write down how to score, I thought to myself this will take a lot of mental energy. Lol. Not quite what I expected and not very relaxing. I laughed with them that pinochle required a lot of thinking. These ladies are older than me and had been playing pinochle since they were in their teens or earlier. The birthday guest of honor, Elona and I were the ones learning how to play the game. I joked and complained a bit as they were explaining how to play, and I loved how they talked us through all the steps. It was a lot of fun after I got out of my head about all the thinking required. Donating Blood Platelets Yesterday I donated blood platelets for the first time after receiving a request from a friend who had a family member who needed them. I've donated blood numerous times, so this is definitely something new and different. The process was very streamlined with the application and forms being online, I was ready to go. I am a bit of a researcher so I did go to YouTube to know what to expect. I didn't say doing new things didn't mean you couldn't research, did I? Lol. I was in an out a within few hours. Resident Alien The third recent new thing I did was start watching Resident Alien on Netflix. It's a science fiction series about an alien who comes to earth and takes on human form. Sci-fi is not a genre I watch much so I thought I would try this series out. I found it to be hilarious with quirky characters and great writing. it's light hearted for the most part so I can watch it and get a good laugh. Doing new things regularly is a great way to get out of your comfort zone and keep your mind engaged and active. Would I play pinochle again, yep! I would also donate platelets again. And I'm still watching Resident Alien, I'm almost done with season 2. What's something new you have tried recently? Leave a comment where you are listening to this podcast and share what you see, smell, hear, taste or touch in this moment. You can also email me at barbarafaisonllc@gmail.com. And if social media is better for you, LinkedIn, Facebook, and Instagram, are best. --- Send in a voice message: https://podcasters.spotify.com/pod/show/barbara-faison/message Support this podcast: https://podcasters.spotify.com/pod/show/barbara-faison/support

5 live Science Podcast
Artificial platelets, Bonobos and a tribute to Peter Higgs

5 live Science Podcast

Play Episode Listen Later Apr 14, 2024 51:00


Dr Chris Smith and the Naked Scientist team present the latest science news, analysis and breakthroughs. In this week's episode….Scientists invent artificial platelets to help us clot blood better, why it might be time to reappraise the peace loving nature of Bonobos, why the moon apparently turned itself inside out in the past. Plus as a special tribute to the revered British Scientist Peter Higgs who died this week aged 94, his friend Lyn Evans tells us about the 40 year search for the Higgs boson particle that provides some answers to life, the universe and everything…Get the podcast from the BBC Sounds app.

The Naked Scientists Podcast
Artificial platelets, and angry primates

The Naked Scientists Podcast

Play Episode Listen Later Apr 12, 2024 29:56


This week on The Naked Scientists: Scientists invent artificial platelets to help clot blood; why it might be time to reappraise the peace-loving nature of bonobos; and why the Moon may have turned itself inside out in the past... Like this podcast? Please help us by supporting the Naked Scientists

IS PHARMACOLOGY DIFFICULT Podcast
Is Pharmacology Difficult Podcast SEROTONIN (5-HT)- PHYSIOLOGICAL ACTIONS -1

IS PHARMACOLOGY DIFFICULT Podcast

Play Episode Listen Later Apr 8, 2024 10:54


Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be discussing Physiological actions of SEROTONIN (5-HT) i.e. 5-Hydroxytryptamine related to Inflammation, GIT, Platelets and Cardio Vascular System (CVS)I will be talking about physiological actions in each of these systems in quite detail. Many surprising facts, research bytes and info talks will be adding spice to the episode.Finally a melodious expression for all the listeners and learners will mark the wrap up moment of the episode!!Pre Order "Bangalore And Bingo!!!" - https://www.amazon.in/dp/B0D12CGWMKFor all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine."Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comIt actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Substack!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

Ditch The Labcoat
Heartbreak and Health with Dr Michael Ward, Interventional Cardiology

Ditch The Labcoat

Play Episode Listen Later Mar 27, 2024 57:16


DISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.                                                  >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.                                                                                  Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. Welcome back to "Ditch the Labcoat," where today we debunked heart health myths with the remarkable Dr. Michael Ward. Did you know stress can literally break your heart? Dr. Ward broke down the realities of Takatsubo cardiomyopathy, stressed the importance of timely intervention in heart attacks, and shared his insights on the Mediterranean diet for cardiac wellness. Plus, we got a glimpse into the high-stakes world of interventional cardiology—straight from the operation room. Stay heart-smart and catch the full episode for a deep dive into the art and science of keeping your ticker ticking! Remember, a healthy heart is a healthy start. Don't miss it!00:00:03 Understanding Takotsubo Cardiomyopathy and Broken Heart Syndrome with Dr. Michael WardDr. Mark Bonta discusses Takotsubo cardiomyopathy, also known as broken heart syndrome, with Dr. Michael Ward. They explore how the condition is often triggered by emotional stress, such as the loss of a loved one, leading to acute heart failure.00:01:03 Discussion on the Heart as a Muscle and Cardiac ConditionsDr. Michael Ward discusses the heart as a muscle that pumps and the various cardiac conditions patients may face, such as heart attacks, heart failure, and heart rhythm problems. The conversation emphasizes the importance of understanding the basic function of the heart for better management of cardiac health.00:02:26 Discussion with Dr. Michael Ward on Interventional Cardiology and Hypertrophic CardiomyopathyDr. Michael Ward is an expert in interventional cardiology who helps people prevent and recover from heart-related issues. He also focuses on hypertrophic cardiomyopathy, a genetic condition affecting the heart. With a background in both medicine and research, he is a valuable asset at Western University in London, Ontario.00:03:50 Interview with Dr Michael Ward, Interventional CardiologistDr. Michael Ward, an interventional cardiologist with both an MD and a PhD, discusses his background in cell-based gene therapy and his interest in cardiovascular medicine. He shares insights on heart health, the importance of vacations for mental health, and his balanced lifestyle.00:07:18 Insight into the Fascinating Aspects of the Heart from an Interventional Cardiology PerspectiveDr Mark Bonta, an interventional cardiologist, shares his perspective on the intricate nature of the heart, highlighting how it responds to various stimuli and stressors. He emphasizes the role of the cardiovascular system in determining life and death outcomes and the potential for improving quality of life through cardiology interventions.00:11:14 Discussion on Interventional CardiologyDr. Mark Bonta discusses their work in interventional cardiology, including responding to emergencies like heart attacks and performing procedures in the catheterization laboratory. They describe the challenges faced by patients with heart conditions and the range of cases they handle.00:13:26 Understanding Cardiovascular System with Dr. Michael WardDr. Michael Ward talks about atherosclerosis as the accumulation of plaque in the arteries, which can lead to heart issues like angina and heart attacks. The discussion also touches on the difference between chronic accumulation of plaque and acute blockages causing heart attacks.00:18:01 Understanding Acute Heart Attacks and Plaque Ruptures in ArteriesAcute heart attacks can occur when plaque ruptures inside an artery, leading to a clot that blocks the artery and causes the heart attack. Platelets play a crucial role in responding to the rupture and forming clots to heal the affected area.00:19:44 Importance of Timely Intervention in Heart AttacksDuring a conversation between Dr. Mark Bonta and Dr. Michael Ward Interventional Cardiology, they discussed the critical importance of timely intervention in heart attacks. Dr. Bonta mentioned that when a heart attack occurs, time is of the essence as the muscle of the heart is deprived of blood flow. Historically, patients were given aspirin and blood thinners but no interventional procedures were done immediately.00:21:20 Advanced Cardiac Care Protocols in CanadaIn Canada, there are advanced protocols in place for managing ST-elevation myocardial infarction (STEMI) cases, including direct ambulance transportation to hospitals with cath labs. Time is crucial in treating cardiac emergencies to minimize heart muscle damage.00:23:51 Patient Experience in the Cath Lab: What to ExpectThe patient experience in the cath lab involves inserting a needle with a wire into their arteries, either through the wrists or groin. Patients may not feel much during the procedure, but there might be some sensations of discomfort or awareness of the procedure taking place.00:26:56 Understanding the Process of Opening Blocked Heart VesselsIn the conversation between Dr Mark Bonta and Dr Michael Ward Interventional Cardiology, they discuss the process of opening blocked heart vessels during angioplasty procedures. They talk about using topical lidocaine for anesthesia and how temporary discomfort may be felt when the blockage is being opened up. Dr Ward explains that a stent is not a rigid pipe but a meshwork that is placed in the living system of the coronary artery.00:29:41 Understanding Interventional Cardiology and StentingInterventional cardiology involves using contrast dye and x-ray cameras to map arteries and identify blockages. Stents are used to provide support and prevent arteries from narrowing, improving blood flow to the heart muscle. The decision to place a stent is based on the degree of blockage and the impact on blood flow.00:34:10 Discussion on Heart Health Interventions and Medical ManagementThe conversation between Dr. Mark Bonta and Dr. Michael Ward Interventional Cardiology delves into the topic of heart health interventions and the importance of medical management in cardiac care. They discuss the limitations of interventions like stents in treating moderate blockages and emphasize the significance of lifestyle changes and medications in preventing heart attacks and strokes.00:38:32 Preventing Cardiovascular Disease Through Exercise and MedicationsDr. Mark ...

Dr. Sex Fairy
Ep. 119: From Platelets to Pleasure

Dr. Sex Fairy

Play Episode Listen Later Mar 19, 2024 27:47


In this episode of the Dr. Sex Fairy Podcast, join me as I delve into the fascinating world of regenerative medicine and its impact on sexual health and pleasure. My guest is Dr. Gayan Poovendran, a leading expert in sports medicine, and he joins us to explore the innovative treatments of PRFM and exosomes. Together, we unravel the science behind these cutting-edge therapies and discuss their potential to revolutionize sexual function, pleasure, aesthetics, hair loss, and joint health. Discover how these breakthrough treatments are reshaping the landscape of sexual wellness and paving the way for a future of enhanced pleasure and vitality. To schedule a virtual or in-office consultation with Dr. Bawa: https://www.bawamedical.com/contact/To learn more about Dr. Sex Fairy supplements:https://shop.bawamedical.com/collections/supplements To watch Dr. Sex Fairy in video format: https://www.youtube.com/@drsexfairy To learn more about sexual wellness: https://www.bawamedical.com/sexual-health/ TikTok: https://www.tiktok.com/@drsexfairy Instagram: https://www.instagram.com/therealdrsexfairy/ Facebook: https://www.facebook.com/doctorsexfairy

Blood Podcast
Extended follow-up of axi-cel in indolent NHL; platelets help clear senescent RBCs; novel risk stratification strategy for CNS lymphoma

Blood Podcast

Play Episode Listen Later Feb 8, 2024 18:58


In this week's episode we'll discuss extended follow-up from the ZUMA-5 trial of axicabtagene ciloleucel, or axi-cel. Then we'll learn about the role of platelets in binding and clearing senescent red blood cells. Finally, we'll hear about a new risk stratification strategy for lymphomas of the central nervous system, or CNS. 

MY CHILD'S HEALTHY LIFE RADIO SHOW
Little-Known Secrets to Platelet Prowess: Platelet Overactivation and the Connection to your CRF Score

MY CHILD'S HEALTHY LIFE RADIO SHOW

Play Episode Listen Later Jan 28, 2024 21:10


Get early access to The Perfect Health Lesson, and the calculator discussed in today's lesson. ⁠⁠⁠⁠Click this link now⁠⁠⁠⁠ In today's episode: Platelets, also known as thrombocytes, are small cell fragments in the blood that play a crucial role in the body's ability to stop bleeding and form blood clots. When there is an injury or damage to blood vessels, platelets become activated and adhere to the site of injury, where they release various substances to initiate the blood clotting process. This is a normal and essential part of the body's response to injury, preventing excessive bleeding. However, when platelets become overactivated, it can lead to problems, especially in the context of cardiovascular diseases (CVD). Platelet stickiness refers to the tendency of platelets, small blood cells, to adhere to each other or to the walls of blood vessels upon activation. Normally, platelets circulate in the blood in an inactive state. However, when there's injury or damage to blood vessels, platelets become activated, changing shape and releasing chemical signals that prompt them to stick together (aggregate) and adhere to the damaged vessel walls. This adhesive property of platelets is crucial in the process of hemostasis, which is the body's mechanism to prevent excessive bleeding. When blood vessels are injured, platelets adhere to the site of injury, forming a plug to seal the damaged area. This initial platelet aggregation is followed by the coagulation cascade, involving the formation of a blood clot to further stem the bleeding. There are 7 new secrets you will learn about reducing platelet stickiness in this lesson. While platelet stickiness is essential for preventing excessive bleeding, abnormal or excessive platelet aggregation and adhesion can lead to issues like thrombosis, where blood clots form within blood vessels without an injury or obstruction, potentially causing blockages and leading to conditions such as heart attacks or strokes. Therefore, the regulation of platelet stickiness is crucial for maintaining proper hemostasis and preventing abnormal clotting.

Bloodworks 101
"Curiosity and Collaboration" - Dr. Amily Guo (S5 E16)

Bloodworks 101

Play Episode Listen Later Jan 11, 2024 19:28


Platelets are the part of blood that help control bleeding by collecting and clotting at the site of an injury. However, the role that platelets play in immune response is emerging and exciting, and Bloodworks Research Institute is privileged to now be home to one the most brilliant minds investigating this relationship: Dr. Li "Amily" Guo. Bloodworks 101 producer Helen Pitlick sat down with Dr. Guo to learn about her research—and the curiosity that drives her. 

The Medicine Grand Rounders
High-value Approach to Blood Products: RBC, Plasma, and Platelets

The Medicine Grand Rounders

Play Episode Listen Later Jan 5, 2024 31:45


Dr. Moises Auron discusses about his high value approach to transfusion of blood products: PRBC, FFP, and Platelets.

WBEN Extras
Maria Turner from the Roswell Park Donor Center on the need for blood and platelets

WBEN Extras

Play Episode Listen Later Nov 27, 2023 6:58


Maria Turner from the Roswell Park Donor Center on the need for blood and platelets

Omaha's Health & Community Podcast
The Best Cancer Blood Tests

Omaha's Health & Community Podcast

Play Episode Listen Later Nov 5, 2023 10:37


While it's true that the majority of people will have a run-in with some kind of cancer in their lifetime, we need to remember that no 2 cancers are the same, and your overall metabolic health has a huge impact on how your body will manage the cancer and what your survival rates will be, plus which treatment path you should go down. To test your body's current metabolic health status when dealing with cancer, there's a number of simple blood tests you can run that will show how well (or poorly) your body is handling the tumor load.  You'll want to run the following tests: CBC and specifically look at WBC, Platelets, and the Neutrophil to Lymphocyte ratio Comprehensive Metabolic Panel - Creatinine, Liver enzymes, Alkaline Phosphatase Inflammatory markers - LDH, ESR, hs-CRP

Your Health. Your Story.
The Story of IV Platelet Therapy with Tapley Holland

Your Health. Your Story.

Play Episode Listen Later Nov 2, 2023 54:00


Many people aren't aware there is a therapy available that takes what is already within us and can address the underlying causes of conditions, such as inflammation and immune system imbalances. Our guest today is here to share new research on the regenerative properties of platelets for individuals grappling with persistent symptoms and related co-infections of long-haul COVID, Lyme disease, mold exposure, and more.This is the Story of IV Platelet Therapy with Tapley Holland.EPISODE VIDEO HIGHLIGHTSWatch the Entire EpisodeThe Power of Platelets in TruDOSE Intravenous TreatmentsRebooting the Immune and Repair Systems with TruDOSEUnderstanding the Impact of Cellular Memory in Health RecoveryLyme Disease Patients Find Hope with TruDOSE TherapyThe Impact of TruDOSE on Mycotoxin ExposureCustomizing Health Solutions with TruDOSETruDOSE Therapy: A Transformative Solution for Chronic Health ChallengesInnovative Treatments for Pediatric ConditionsCONNECT WITH TAPLEY HOLLANDWebsite - TruDOSE TherapyListen to Tapley's first ‘Your Health. Your Story.' podcast episode: The Story of TruDose PRP with Tapley Holland CONNECT WITH INNOVATIVE MEDICINE Website Instagram Facebook YouTube CONNECT WITH CASPAR SZULC Instagram Twitter LinkedIn LEARN ABOUT NADOVIM - A BREAKTHROUGH IN BRAIN HEALTHDoctor-formulated, clinically-tested true NAD+ supplement for focus, concentration and cognitive support. Visit our website and save 10% on your first order by using coupon code NADOVIM10. Website Instagram Facebook 'YOUR HEALTH. YOUR STORY.' PODCAST Follow us on Spotify Follow us on iTunes Subscribe on ...

Bloodworks 101
Extending Platelet Shelf Life in the Stolla Lab (S5 E7)

Bloodworks 101

Play Episode Listen Later Oct 26, 2023 12:26


Platelets -- the part of blood that helps control bleeding -- are lifesaving for cancer patients, those receiving organ or bone marrow transplants, victims of trauma, and patients undergoing open-heart surgery. But donated platelets have a shelf-life of only 5-7 days. What if we could extend the life of platelets? What if modern platelet use is based on outdated assumptions? Dr. Moritz Stolla of Bloodworks Research institute wants to find out.

Steve Cochran on The Big 89
Is it worth taking a sick day for a head cold, or is it just a snot-so-serious situation?

Steve Cochran on The Big 89

Play Episode Listen Later Oct 17, 2023 18:55


Chief Medical Officer at Northwestern Medicine Central DuPage Hospital Dr. Kevin Most joins the Steve Cochran Show to discuss whether it's necessary to take time off from work for a head cold, the reasons behind the blood shortage in the United States, and why people often delay seeking medical attention until they perceive something as 'extremely wrong.' Dr. Kevin Most's Steve Cochran Show Notes: October is Breast cancer Awareness Month Breast cancer is the 2nd most common cause of Cancer among women, second only to skin cancer It makes up 30% of all new female cancers Annual cases in the US are approaching 400,000 a year. 43,000 women will die from breast cancer in the US this year Median age for breast cancer detection is 62 years old, this means that 50% of new cases of breast cancer occur in women under 62 years old. Women have a 1 in 8 chance of developing breast cancer at some time in their lives Incidence has increased slightly each year, better diagnosis? More awareness? Or environmental Breast cancer is the second leading cause of cancer death in women (lung cancer is the leading cause of cancer death in women) Breast cancer death rates have declined since 1989- results of finding cancer earlier, better treatments, screening awareness Risk factors include- alcohol consumption, obesity, sedentary lifestyle, women who have not had children, not breast feeding, hormonal therapy post menopause In May of 2023- recommendations changed to recommend that annual mammograms start at age 40 Mammogram timing at Covid and Flu shots – because of the immune response and the possible swelling of lymph nodes with the shots, many are recommending completing a screening mammogram 4-6 weeks following the vaccine The reason for this is the inflamed lymph nodes may lead to a false positive reading on a mammogram and lead to additional testing that in reality is not needed The best option is get the mammogram and then follow up with the annual vaccines, the timing should work Blood shortage- Red Cross provides about 40% of all blood in the US Red Cross has seen donations drop 25% over the past few months and is now at a critical level Versiti Blood center of Illinois is a  large donation company in the suburbs with many sites to donate Donations have declined by 25% since August- reasons include natural disasters, vacations, back to school Red Cross is pushing for allowing high schools to do blood drives again, these were stopped during the Covid pandemic This halt has not only impacted the amount of blood collected but also is seen as missing an opportunity to get new donors in line for continued donations People can donate blood every 8 weeks When you donate blood it is used in different ways- Red Blood Cells can be used for up to 30 days, Platelets which help with clotting last 5 days, Plasma which has clotting factors last up to a year as it is able to be frozen Are the fall drinks good for you Starbucks, Peet's , Dunkin Donuts, are now pushing the Fall Drinks, but do you know how they impact your nutrition Pumpkin Spice Latte   470  calories, 16g of fat and 60g of sugar – Venti or large size Perspective 2,000- 2,500 calories a day total is a goal.  60 g of Fat a day is a goal,  24 grams of sugar is a goal Christmas is right around the corner – Peppermint Mocha with whole milk- Venti – 550 calories, 22 grams for fat, 66 grams of sugar We know coffee has some great health benefits including antioxidants, decreases the risk of diabetes, decreases the risk of some cancers and may protect you from dementia, decreases the risk of depression So, Not saying stop drinking coffee just understand the health impact when adding all the flavors and sweeteners. Full Body MRI's- status symbol?  Realistic-  Kim Kardashian, Paris Hilton, Cindy Crawford touting these? Some celebrities are promoting a full body MRI  done by a company Prenuvo, saying it is life saving Some celebrities are offering discount codes The scans cost $2,500 and are not covered by insurance, The company started in 2018, touts the scan as preventive and looks for illnesses before they are detected by traditional screening. They have 8 locations across North America and will be opening 12 more. There is one in Chicago The company is pushing this test as proactive instead of reactive You can go on their website and look at the different types of cancer that their scan may be able to identify Currently each type of cancer has some screening process, when taken as a group of tests this can be cumbersome and expensive Consider colonoscopy, mammograms, PSA tests, PAP tests  these are all tests we use to identify cancers thru screening, time consuming and fragmented, but in most cases still the “gold standard” for screening. Some cancers have no screening tests currently, like pancreas, ovarian, brain, kidney, and liver. While MRI would certainly identify some of these tumors at an early stage, the MRI results are not always as accurate as one would hope  and thus lead to additional testing and risky procedures which may not be appropriate (biopsies) Currently not supported by most physicians We certainly do not have enough scanners in the US if this was going to be considered Could it help with screening for those who have put off screening?  Could it identify a cancer early in the lungs, brain or pancreas that may be lifesaving, or at least life extending? The company recommends these scans every two years Is this a technology that is just ahead of its time and will be the gold standard in the future???? With so few sites, it does come down to those who can afford the test. The test may fill the needs of a population who is looking for more information about their risk for illnesses, like genetic testing See omnystudio.com/listener for privacy information.

For The Record
Episode 64: Exosomes & The Power of Platelets with Atta Behfar, MD, PhD & Saranya Wyles, MD, PhD

For The Record

Play Episode Listen Later Aug 25, 2023 69:02


This may be our most fascinating podcast ever! We are joined by the Co-Founder of Rion, Inc., researcher and pioneer of regenerative medicine, and Cardiologist at the Mayo Clinic, Atta Behfar, MD, PhD. We're also joined by Saranya Wyles, MD, PhD, Associate Professor of Dermatology, Program Director of Clinical Regenerative Medicine Education at Mayo Clinic and the Principle Investigator for Rion Aesthetic's flagship product, (plated)™.  Dr. Behfar spent several years in the initial stages of research getting a deep understanding of what influences cells to participate in wound healing. His research led him to find the major gap- communication-  which is where exosomes come into play. They are the mechanism by which cells communicate with one another and make things happen in the body. Next, it was about finding the best communicators which led him and his research team to identify a particular group of platelet-derived exosomes that were specifically communicating about regeneration and repair.  This was a true needle in a haystack endeavor, and thankfully it's paid off-  it's propelled regenerative medicine in aesthetics to a whole new level.  Several years later, his findings turned into Rion, Inc as he continued on with research focused on organ regeneration (eventually the heart), and as a byproduct, he found an invaluable application within aesthetics. Looking into the future, he discusses what is possible with injectable exosomes to supercharge what filler, toxin and biostimulators can do in the tissue.  We won't need to just fill or relax wrinkles, but there is the potential to repair the tissue enough that it's no longer a concern. If Dr. Behfar is where it started, Dr. Wyles is how it's going. Not only is she an expert in regenerative medicine, but she's also a practicing Dermatologist. She is using exosome technology in her practice daily, and to hear her discuss the effectiveness and results she sees with (plated)™ is remarkable. She is using it as a primer for her patients before procedures, as their primary skincare product, and as a post-treatment wound-healing accelerant. While this is not a sponsored Rion Aesthetic's podcast, the results she's seeing clinically, not just in the lab, are cause for major kudos to the Rion Aesthetics research team! She's working on next steps toward future research involving hair growth, injectable exosomes and atopic dermatitis among other potential uses- all pending the FDA of course. She truly is the perfect intersection of where the research lab meets the treatment chair.  We are definitely at the tip of the spear in regenerative medicine with this episode. It's rare to sit down with two of the best and brightest minds on the research front and get a solid breakdown of the science and the clinical application of something as novel as platelet-derived exosomes. In addition, Dr Wyles provides a checklist of sorts for you to consider before bringing exosomes into your practice. It's important to check things like donor quality, batch consistency, batch effectiveness, platelet or stem-cell derived, and to ask for the clinical research that is backing the product. We know Rion Aesthetics has no shortage of research available, and from the sound of what's next, they are only getting started!

Critical Care Time
Journal Club - Platelets and Lines

Critical Care Time

Play Episode Listen Later Jul 19, 2023 33:09


Join Nick & Cyrus as they take on their first journal club episode! This week the duo provides their take on the NEJM paper from van Baarle and colleagues entitled Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia. They also provide some of their tips and tricks for safe central line placement. Give it a listen and let us know what you think! Hosted on Acast. See acast.com/privacy for more information.

Nature and Science 4 Kids
What is the Tallest Tree in the World?

Nature and Science 4 Kids

Play Episode Listen Later Jul 19, 2023 13:06


What is the tallest tree in the world? Why does blood make scabs? Where can I find dinosaur bones? Find out the answer to these questions here with Moosejaw Matt. We also have some thanks and birthday shout-outs for you.

Lab Values Podcast (Nursing Podcast, normal lab values for nurses for NCLEX®) by NRSNG

Overview Platelets Normal Value Range Pathophysiology Special considerations Elevated platelet levels Decreased platelet levels Nursing Points General Normal value ranges 100,000 – 450,000/mcL Also known as – Thrombocytes Pathophysiology Formed from Megakaryocyte Formed from bone marrow Produces 1000-3000 platelets Injury occurs at site Collagen releases activators Thrombocytes activate “sticky fingers”, which allow them to bind together. Travel to site (along with other clotting factors) Adhere to site, increase stimulation for other PLT, until clot is formed with fibrin Special considerations Use a lavender top tube (EDTA) Often sent in CBC Abnormal lab values Elevated platelets (thrombocytosis) Cancers Absence of a spleen Breaks down platelets Birth control Polycythemia vera Overproduction of cells Treatment via bloodletting, medications or hydration Decreased platelets (thrombocytopenia) ITP (Idiopathic thrombocytopenic purpura) Autoimmune disease Medications Hemorrhage Treated with transfusion Leukemia Treated with chemotherapy/radiation Medications Some diuretics Nonsteroidal anti-inflammatory drugs (NSAIDs) Ranitidine Some antibiotics Assessment Assess for signs of petechia (small purplish blemishes, indicating bleeding) Therapeutic Management Control and stop hemorrhage Replace platelets via transfusion Consider stopping or changing medications that cause thrombocytopenia Nursing Concepts Lab Values Clotting Patient Education For patients who have bleeding disorders, instruct patients to be cautious of injury. If patient has thrombocytopenia, instruct patient to seek emergency treatment in the event of bleeding that does not stop. **DISCLAIMER – The video states that the normal value of platelets is 100,000 – 400,000 cells/mcL. The correct information is 100,000 – 450,000 cells/mcL.

Birthing Instincts
#314 Low Platelets & Deficiencies of Wisdom

Birthing Instincts

Play Episode Listen Later Jun 21, 2023 64:16


Today, Blyss meets up with Dr. Stu at his new homestead for some in-person podcasting! They discuss thrombocytopenia and low levels of independent thought in so many health care providers. Learn about the importance of a complete blood count and peripheral blood smear, the risks associated with certain medications, and the key characteristics of gestational thrombocytopenia. They also discuss various platelet count thresholds and what they mean for the expecting mother.Blyss explores the world of nutrition and supplements to help increase platelet count during pregnancy. The duo covers a range of options, from vitamins and minerals to specific foods and supplements that can aid in building healthy blood and increasing platelets.In this episode of Birthing Instincts:Understanding platelet count in pregnancyImportance of complete blood count and peripheral blood smearThrombocytopenia and preeclampsiaManagement of gestational thrombocytopeniaIncreasing platelets with nutritionDiscerning truth in advertisingThis show is supported by:LMNT | Go to drinklmnt.com/birthinginstincts to get a free sample pack with every orderNeeded | Use code BIRTHINGINSTINCTS for 20% off your first month or first 3 months of a one-month subscription at thisisneeded.com. BIRTHFIT | Go to birthfit.com and use the code INSTINCTS1 for a discount on the Basics Prenatal program, or INSTINCTS2 for a discount on the Basics Postpartum program.Resources:15 Food to Increase Platelet Count in Your BloodConnect with Dr. Stu & Blyss:Instagram: @birthinginstincts / @birthingblyssWebsite: birthinginstincts.com / birthingblyss.comEmail: birthinginstinctspodcast@gmail.com Call-in line: 805-399-0439This show is produced by Soulfire Productions

Discover CircRes
May 2023 Discover CircRes

Discover CircRes

Play Episode Listen Later May 18, 2023 36:26


This month on Episode 48 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the April 28th issue of Circulation Research. This Episode also includes a discussion between Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova, who all contributed to manuscripts to the May 12th Compendium on Covid-19 and the Cardiovascular System.     Article highlights:   Heijman, et al. Mechanisms of Enhanced SK-Channel Current in AF   Chen, et al. IL-37 Attenuates Platelet Activation   Enzan, et al. ZBP1 Protects Against Myocardial Inflammation   Compendium on Covid-19 and the Cardiovascular System.   Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. Today, I'm going to be highlighting articles from our April 28th and May 12th issues of Circulation Research. I'm also going to have a chat with Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova, who all contributed to articles in the May 12th COVID Compendium. But before we have that interview, let's first talk about some highlights.   The first article I want to present is titled Enhanced Calcium-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation. This article is coming from the University of Essen by Heijman and Zhou, et al. Atrial fibrillation is one of the most common forms of heart arrhythmia in humans and is characterized by irregular, often rapid heartbeats that can cause palpitations, dizziness and extreme fatigue. Atrial fibrillation can increase a person's risk of heart failure, and though treatments exist such as beta blockers, blood thinners and antiarrhythmia medications, they can have limited efficacy and side effects. A new family of drugs in development are those blocking small-conductance calcium-activated potassium channels called SK channels, which exhibit increased activity in animal models of AF and suppression of which attenuates the arrhythmia. In humans however, the relationship between SK channels and atrial fibrillation is less clear, at least in terms of SK channel mRNA levels. Because mRNA might not reflect actual channel activity, this group looked at just that and they found indeed that channel activity was increased in cardiomyocytes from atrial fibrillation patients compared to those from controls even though the mRNA and protein levels themselves were similar. The altered currents were instead due to changes in SK channel trafficking and membrane targeting. By confirming that SK channels play a role in human atrial fibrillation, this work supports the pursuit of SK channel inhibitors as possible new atrial fibrillation treatments.   The next article I want to present is titled IL-37 Attenuates Platelet Activation and Thrombosis Through IL-1R8 Pathway. This article comes from Fudan University by Chen and Hong, et al. Thrombus formation followed by the rupture of a coronary plaque is a major pathophysiological step in the development of a myocardial infarction. Understanding the endogenous antithrombotic factors at play could provide insights and opportunities for developing treatments. With this in mind, Chen and Hong, et al. investigated the role of interleukin-1 receptor 8, or IL-1R8, which suppresses platelet aggregation in mice, and of IL-37, a newly discovered human interleukin that forms a complex with IL-1R8 and is found at increased levels in the blood of patients with myocardial infarction. Indeed, the amount of IL-37 in myocardial infarction patients negatively correlates with platelet aggregation. They also show that treatment of human platelets in vitro with IL-37 suppresses the cell's aggregation and does so in a concentration-dependent manner. Moreover, injection of the protein into the veins of mice inhibits thrombus development and better preserves heart function even after myocardial infarction. Such effects were not seen in mice lacking IL-1R8. This suggests IL-37's antithrombotic action depends on its interaction with the receptor. Together, the results suggest IL-37 could be developed as a antithrombotic agent for use in MI patients or indeed perhaps other thrombotic conditions.   The last article I want to present before our interview is titled ZBP1 Protects Against Mitochondrial DNA-Induced Myocardial Inflammation in Failing Hearts. This article is coming from Kyushu University and is by Enzan, et al. Myocardial inflammation is a key factor in the pathological progression of heart failure and occurs when damaged mitochondria within the stricken cardiomyocyte release their DNA, triggering an innate inflammatory reaction. In a variety of cells, DNA sensors such as Z-DNA-binding protein 1 or ZBP1 are responsible for such mitochondrial DNA-induced inflammation. In theory then, it's conceivable that therapeutic suppression of ZBP1 might reduce myocardial inflammation in heart failure and preserve function. But as Enzan and colleagues have now discovered to their surprise, mice lacking ZBP1 exhibited worse, not better heart inflammation and more failure after induced myocardial infarction. Indeed, the test animals' hearts had increased infiltration of immune cells, production of inflammatory cytokines and fibrosis together with decreased function compared with the hearts of mice with normal ZBP1 levels. Experiments in rodent cardiomyocytes further confirmed that loss of ZBP1 exacerbated mitochondrial DNA-induced inflammatory cytokine production while overexpression of ZBP1 had the opposite effect. While the reason behind ZBP1's opposing roles in different cells is not yet clear, the finding suggests that boosting ZBP1 activity in the heart might be a strategy for mitigating heart inflammation after infarction.   Cindy St. Hilaire:         The May 12th issue of Circulation Research is our COVID compendium, which consists of a series of 10 reviews on all angles of COVID-19 as it relates to cardiovascular health and disease. Today, three of the authors of the articles in this series are here with me. Dr Mina Chung is a professor of medicine at the Cleveland Clinic. She and Dr Tamanna Singh and their colleagues wrote the article, A Post Pandemic Enigma: The Cardiovascular Impact of Post-Acute Sequelae of SARS-CoV-2. Dr DeLisa Fairweather, professor of medicine, immunology and clinical and translational science at the Mayo Clinic, and she and her colleagues penned the article, COVID-19 Myocarditis and Pericarditis. Dr Milka Koupenova is an assistant professor of medicine at the UMass Chan School of Medical and she led the group writing the article, Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond. Thank you all for joining me today.   DeLisa Fairweather:    Thank you so much for having us.   Mina Chung:   Thank you.   Milka Koupenova:       Thank you for having us, Cindy.   Cindy St. Hilaire:         In addition to these three articles, we have another seven that are on all different aspects of COVID. Dr Messinger's group wrote the article, Interaction of COVID-19 With Common Cardiovascular Disorders. Emily Tsai covered cell-specific mechanisms in the heart of COVID-19 patients. Mark Chappell and colleagues wrote about the renin-angiotensin system and sex differences in COVID-19. Michael Bristow covered vaccination-associated myocarditis and myocardial injury. Jow Loacalzo and colleagues covered repurposing drugs for the treatment of COVID-19 and its cardiovascular manifestations. Dr Stephen Holby covered multimodality cardiac imaging in COVID, and Arun Sharma covered microfluidic organ chips in stem cell models in the fight against COVID-19.   Cindy St. Hilaire          As of today, worldwide, there have been over six hundred million individuals infected with the virus and more than six and a half million have died from COVID-19. In the US, we are about a sixth of all of those deaths. Obviously now we're in 2023, the numbers of individuals getting infected and dying are much, much lower. As my husband read to me this morning, one doctor in Boston was quoted saying, "People are still getting wicked sick." In 75% of deaths, people have had underlying conditions and cardiovascular disease is found in about 60% of all those deaths. In the introduction to the compendium, you mentioned that the remarkable COVID-19 rapid response initiative released by the AHA, which again is the parent organization of Circ Research and this podcast, if I were to guess when that rapid response initiative started, I would've guessed well into the pandemic, but it was actually March 26th, 2020. I know in Pittsburgh, our labs have barely shut down. So how soon after we knew of SARS-CoV-2 and COVID, how soon after that did we know that there were cardiovascular complications?   Mina Chung:               I think we saw cardiovascular complications happening pretty early. We saw troponin increases very early. It was really amazing what AHA did in terms of this rapid response grant mechanism. You mentioned that the RFA was announced, first of all, putting it together by March 26th when we were just shutting down in March was pretty incredible to get even the RFA out. Then the grants were supposed to be submitted by April 6th and there were 750 grants that were put together and submitted. They were all reviewed within 10 days from 150 volunteer reviewers. The notices were distributed April 23rd, less than a month out.   Cindy St. Hilaire:         Amazing.   Mina Chung:               So this is an amazing, you're right, paradigm for grant requests and submissions and reviews.   DeLisa Fairweather:    For myocarditis, reports of that occurred almost immediately coming out of China, so it was incredibly rapid.   Cindy St. Hilaire:         Yeah, and that was a perfect lead up to my next question. Was myocarditis, I guess, the first link or the first clue that this was not just going to be a respiratory infection?   DeLisa Fairweather:    I think myocarditis appearing very early, especially it has a history both of being induced by viruses, but being strongly an autoimmune disease, the combination of both of those, I think, started to hint that something different was going to happen, although a lot of people probably didn't realize the significance of that right away.   Cindy St. Hilaire:         What other disease states, I guess I'm thinking viruses, but anything, what causes myocarditis and pericarditis normally and how unique is it that we are seeing this as a sequelae of COVID?   DeLisa Fairweather:    I think it's not surprising that we find it. Viruses around the world are the primary cause of myocarditis, although in South America, it's the parasite Trypanosoma cruzi. Really, many viruses that also we think target mitochondria, including SARS-CoV-2, have an important role in driving myocarditis. Also, we know that SARS-CoV-1 and MERS also reported myocarditis in those previous infections. We knew about it beforehand that they could cause myocarditis.   Cindy St. Hilaire:        Is it presenting differently in a COVID patient than say those South American patients with the... I forget the name of the organism you said, but does it come quickly or get worse quickly or is it all once you get it, it's the same progression?   DeLisa Fairweather:    Yeah. That's a good question. Basically, what we find is that no matter what the viral infection is, that myocarditis really appears for signs and symptoms and how we treat it identically and we see that with COVID-19. So that really isn't any different.   Cindy St. Hilaire:         Another huge observation that we noticed in COVID-19 patients, which was the increased risk of thrombic outcomes in the patients. Dr Koupenova, Milka, you are a world expert in platelets and viruses and so you and your team were leading the writing of that article. My guess is knowing what you know about platelets and viruses, this wasn't so surprising to you, but could you at least tell us the state of the field in terms of what we knew about viruses and platelets before COVID, before Feb 2020?   Milka Koupenova:       Before Feb 2020, we actually knew that influenza gets inside in platelets. It leads to not directly prothrombotic events, but it would lead to release of complement 3 from them. That complement 3 would actually increase the immunothrombosis by pushing neutrophils to release their DNA, forming aggregates. In cases when you have compromised endothelium and people with underlying conditions, you would expect certain thrombotic outcomes. That, we actually published 2019 and then 2020 hit. The difference between influenza and SARS-CoV-2, they're different viruses. They carry their genome in a different RNA strand. I remember thinking perhaps viruses are getting inside in platelets, but perhaps they do not. So we went through surprising discoveries that it seemed like it is another RNA virus. It also got into platelets. It was a bit hard to tweak things surrounding BSL-3 to tell you if the response was the same. It is still not very clear how much SARS or rather what receptor, particularly when it gets inside would induce an immune response. There are some literature showing the MDA5, but not for sure, may be responsible. But what we found is that once it gets in platelets, it just induces this profound activation of programmed cell death pathways and release of extracellular vesicles and all these prothrombotic, procoagulant form of content that can induce damage around, because platelets are everywhere. So that how it started in 2019 and surprisingly progressed to 2021 or 2020 without the plan of really studying this virus.   Cindy St. Hilaire:         How similar and how different is what you observe in platelets infected, obviously in the lab, so I know it's not exactly the same, but how similar and how different is it between the flu? Do you know all the differences yet?   Milka Koupenova:       No offense here, they don't get infected.   Cindy St. Hilaire:         Okay.   Milka Koupenova:       Done the proper research. The virus does not impact platelets, but induces the response.   Cindy St. Hilaire:         Okay.   Milka Koupenova:       That goes back to sensing mechanism. Thank goodness platelets don't get infected because we would be in a particularly bad situation, but they remove the infectious virus from the plasma from what we can see with function.   Cindy St. Hilaire:         Got it. So they're helping the cleanup process and in that cleaning up is where the virus within them activates. That is a really complicated mechanism.    Milka Koupenova:       Oh, they're sensing it in some form to alert the environment. It's hard to say how similar and how different they are unless you study them hint by hint next to each other. All I can tell is that particularly with SARS-C, you definitely see a lot more various kinds of extracellular vesicles coming out of them that you don't see the same way or rather through the same proportion with influenza. But what that means in how platelet activates the immune system with one versus the other, and that goes back to the prothrombotic mechanisms. That is exactly what needs to be studied and that was the call for this COVID compendium is to point out how much we have done as a team. As scientists who put heads together, as Mina said, superfast response, it's an amazing going back and looking at what happened to think of what we achieved. There is so much more, so much more that we do not understand how one contributes to all of these profound responses in the organs themselves, such as myocarditis. We see it's important and that will be the problem that we're dealing from here on trying to figure it out and then long COVID, right?   Cindy St. Hilaire:         Yeah. Related to what you just said about the mechanism, this cleanup by the platelets or the act of cleaning up helps trigger their activation, is that partly why the antiplatelet and anticoagulant therapies failed in patients? Can you speculate on that? I know the jury's still out and there's a lot of work to be done, but is that part of why those therapies weren't beneficial?   Milka Koupenova:       The answer to that in my personally biased opinion is yes. Clearly, the antiplatelet therapies couldn't really control the classical activation of a platelet. So what I think we need to do from here on is to look at things that we don't understand that non-classically contribute to the thrombotic response downstream. If we manage to control the immune response in some way or the inflammation of the infection or how a platelet responds to a virus, then perhaps we can ameliorate a little bit of the downstream prothrombotic effect. So it's a lot more for us to trickle down and to understand in my personal opinion.   DeLisa Fairweather:    There is one thing that was really remarkable to me in hearing your experience, Milka, is that I had developed an autoimmune viral model of myocarditis in mice during my postdoc. So I've been studying that for the last 20 years. What is unique about that model is rather than using an adjuvant, we use a mild viral infection so it doesn't take very much virus at all going to the heart to induce it. I also, more recently, started studying extracellular vesicles really as a therapy, and in doing that, inadvertently found out that actually, the model that I'd created where we passage the virus through the heart to induce this autoimmune model, we were actually injecting extracellular vesicles into the mice and that's what was really driving the disease. This is really brought out. So from early days, I did my postdoc with Dr Noel Rose. If you've heard of him, he came up with the idea of autoimmune disease in the '50s. We had always, in that environment, really believed that viruses were triggering autoimmune disease and yet it took COVID before we could really prove that because no one could identify them. Here we have an example and I think the incidence rates with COVID were so high for myocarditis because for the first time, we had distinguished symptoms of patients going to the doctor right at the beginning of their infection having an actual test to examine the virus, knowing whether it's present or not, whether PCR or antibody test, and then being able to see when myocarditis happened.   Cindy St. Hilaire:         Yeah. I think one thing we can all appreciate now is just some of the basic biology we've learned on the backend of this. Actually, those last comments really led well to the article that your team led, Dr Chung, about what we call long COVID, which I guess I didn't realize has an actual name, post-acute sequelae of SARS-CoV-2 or PASC is the now more formal name for long COVID. But what is it? We hinted at it that there's these bits about autoimmune and things like that. What counts as long COVID?   Mina Chung:   Yeah. Our article was led by Tamanna Singh. She did a fantastic job of putting this together. We've had, and others, theorized that the huge palette of symptoms that you can experience post-COVID, they can affect all these organ systems with brain fog, these atypical chest pains, postural orthostatic tachycardia, a lot of palpitations, atrial fibrillation, many weakness and fatigue. To us, really, you can get GI symptoms. We've been very interested in, is this an autoimmune phenomenon directed against nerves and all those things. It's also very interesting because many of the non-COVID syndromes that existed pre-COVID like POTS and chronic fatigue syndrome and a lot of other syndromes are associated with autoantibodies. So that is a very interesting area to explore. Is there a persistence of viral fragments. Is there autoimmunity? Is it also a component of persistence of the damage from the initial infection? So it's an area that still needs a lot of work and a lot of work is going into it, but this is like a post or inter pandemic of itself, so hopefully we'll get more insights into that.   Cindy St. Hilaire:         Yeah, it's really interesting. I have a friend who has very debilitating long COVID and one of her doctors had said, "If I didn't know any better, I would just describe this as a autoimmune type X." What do we know, I guess, about the current hypothesis of the pathogenesis of PASC? Are there any prevailing theories right now as to why it's occurring? Is the virus still active or is it these domino effects that are leading to multi-organ collapse of some sort?   Mina Chung:   Yeah. In some people, persistent viral particles can be identified for months, but whether or not that's what's triggering it, it's hard to know. We see more autoimmune disease that's been reported and various antibodies being reported. So those are clearly processes to be investigated. The microthrombosis is still up there in terms of potentially playing a role in long COVID.   Milka Koupenova:       Mina, you probably know better because you see patients, but to all I have been exposed to, long COVID does not really have a homogeneous symptom presentation and then a few theories as to what may be going on in these patients. Not everybody has a microthrombosis. Not everybody have a D-dimer elevated, but some people do. Some people have, as you pointed out, these spectacularly profound brain fog. People can't function. It's probably your friend, Cindy, right?   Cindy St. Hilaire:         Yeah.   Milka Koupenova:       So one of the theories that I have been, from a viral perspective, very interested in is that a lot of the symptoms in certain individuals such as fatigue, brain fog, sensitivity to light and skin can very well be explained by a flare-up of Epstein-Barr virus that may be what SARS-CoV-2 somehow is inducing. I don't know, DeLisa, what your experience with long COVID is as a scientist. I hope only. But I would like to hear your perspective too because it's so heterogeneous and it is amazing what happens.   DeLisa Fairweather:    I have a very interesting perspective from a number of different directions. One, as I mentioned before, my long history with Dr Rose and I've written many articles theorizing how viruses could cause autoimmune disease. This has grown and really, I think this has been extremely revealing during COVID for many of those theories. One thing that I write about in the review for this article is that mast cells, from all the research I've done with myocarditis in our model, mast cells are central to what is driving everything. We show they're the first innate immune cell acting as an antigen-presenting cell, completely driving the response in a susceptible pattern. One of the things that's very important in autoimmune disease is both sex and race. I'd say one of the big weaknesses we have in myocarditis pre-COVID and post-COVID has been ignoring what's going on with race. In the United States, myocarditis is 90%, 95% white men that are under 50 years of age and most of the cases are under 40 or some of the ones really associated with sudden cardiac death are under 30. So it's very specific. I've been studying sex and race differences and we see those exact differences in our animal models. In animal models, whether you're susceptible or not depends on how many mast cells you have. Well, I've proposed from the beginning, looking, I've written a lot of different sex difference reviews looking at viruses and autoimmune disease with different autoimmune diseases and hypothesizing and really seeing that mast cells do a lot of the things we're talking about. They have all of the receptors, the whole group of them that have been related to SARS-CoV-2 so they can be activated or stimulated by the virus itself. They act as a antigen-presenting cell. They're critical in the complement pathway as well as macrophages. We see the dominant immune phenotype really being macrophages. Mast cells just are usually not counted anywhere. And of course, these receptors, a lot of them have to do with enzymes and things that are all related to mast cells pathways. Then how they activate the immune response and lead it towards the pathway that leads to chronic autoimmune disease with increased autoantibodies in females, mast cells are very different by sex. This has to do also when we talked in the Review about myocarditis and pericarditis. It's both those appearing. Although clinically, we have really boxed them as separate things, because there is some definite clinical pericarditis phenotypes that are different, myocarditis in animal models is always myopericarditis. It always then, in that outer pericardial areas where mast cells sit, they sit around the vascular area in most concentrated. So when they degranulate, we see inflammation coming in the vessel, but really concentrated with fibrosis there and along the pericardium. So that's very typical of what's going on. When we shift anything that shifts that, it changes whether you have more pericarditis or less pericarditis and the vascular inflammation by altering anything that affects the mast cells. I talk a little bit about in the review, I think there's only been a few recent things looking at it in COVID, but I think mast cells and certain susceptibility to autoimmune diseases that occur more often in women can really predispose.We need to pay more attention to mast cells and what they might indicate for all these pathways.   Milka Koupenova:       I think we should study the platelet mast cell access at this point.   DeLisa Fairweather:    Yes.   Milka Koupenova:       Because as you're talking about these sex differences, which is spectacular, these things to me are so mind-boggling how one, the infection itself would be more prevalent in men, but then long COVID is more prevalent in women. All of these things and why we understand so very little, what we found about a few years ago in the Framingham Heart Study in the platelets from those people is that all toll-like receptors are expressed at the higher level in women and they associate with different things between men and female. For instance, toll-like receptors in women will associate more with a prothrombotic response while in male with pro-inflammatory response. I think they grossly underestimate the amount of our sex differences from cell to cell.   DeLisa Fairweather:    It is, yeah.   Mina Chung:   One other thing that I learned about the sex differences from this compendium is Mark Chappell also notes, you mentioned TLR and TLR7 and ACE2 are X chromosome in an area that he says escapes X-linked inactivation. So it could very well be involved in further.   DeLisa Fairweather: Further, yeah. And ACE2 is expressed more highly in male cells for what's been researched because of the sex difference in COVID, both the COVID infection   Cindy St. Hilaire:         So a variety of organ systems are impacted in patients with PASC, also referred to as long COVID, the lungs, the heart, the pancreas, the GI system, pretty much any system, the brain, nervous system. We've just been talking about the mast cell impact. I was really thinking in my head, well, the one thing that connects all of it is the vasculature. I'm a vascular biologist, so I have certain biases, I'm sure, but how much of the sequelae that we see is a function of vascular phenotypes?       Milka Koupenova:       I do think the vasculature is super important. It's clear that not all endothelial cells, for instance, will pick up the virus and respond to it. That's why you have this patchy breakage when you look at autopsies. Hence, platelets will respond according to what's local. That's why you find these micro thrombotic events at certain places. Why does it happen in each organ? How does the virus get to each organ to respond? Or is it just inflammation, but why is it in specific places? That's what we don't understand. That's where we need to go. Perhaps, as DeLisa points out, perhaps it's a lot more complicated than how we traditionally think of thrombosis. Actually, my personal bias, again 100% sure that it is a lot more complicated than the traditional mechanisms that we have understood, and that's where the immune system comes and autoimmunity perhaps stems from and they probably speak to each other, right? It's not just one thing.   DeLisa Fairweather:    Yeah. I think really, EVs are bringing lots of understanding. A lot of things we used to just think were maybe free-floating and the serum are inside EVs. I think that the immune response is perhaps even more specific than we ever thought and more regulated than we ever understood.   When an EV comes through a cardiomyocyte, whether it's from the mitochondria or through a lysosome, is part of what goes into its outer membrane, something that tells the immune system that that came from the heart, so it knows to go. This will solve a lot of our questions with autoimmune disease if it's very specific like that. It doesn't just have to be the release of free-floating cardiac myosin. We know cardiac myosin is the driver of the autoimmune response in myocarditis, but they're probably  much more fine-tuned.   Cindy St. Hilaire:         Yeah. I just would love to end with hearing from each of you. You each have your own domain of specialty. If I gave you a massive pot of money, what would be the question you would want to tackle? What's the gap you would love to answer?   Milka Koupenova:       We still don't understand specifically what kind of vesicles are coming out, what are their contents in addition to those vesicles. We don't understand. When it comes to platelets, what comes from their granules? We see these breakages of the membrane. Those are non-granule proteins, and non-granule proteins, they serve as dangerous associated molecular pattern signals and can be profoundly inflammatory to the surrounding environment, can be procoagulant. What are those? How are they affecting the surrounding environment? Ultimately, why is there a microthrombi? Why is there not a profound thrombosis everywhere? Thank goodness there isn't, but why isn't? That's what I would do with my money.   DeLisa Fairweather:    I think I would do something very similar. All of our research in our animal model, on the one side, we are looking in this viral myocarditis animal model and finding the EVs that come from that are driving myocarditis. On the other hand, we're using EVs that come from healthy human plasma or fat, and we're seeing a profound downregulation of everything if you give it early and we're trying to see how late you can give it and still get an effect. So looking at those and really understanding the components in the context of COVID and COVID vaccines to understand those components, I really think that's the future of where we're going to find what's causing disease and also how we can find therapies. They may be able to reverse this.   Mina Chung:   Yeah, I'm interested very much in the autoimmunity and the autoantibodies that are    and how they may react with those microthrombi. Perhaps there's autoantibodies within a lot of that material. We're looking at using human and pluripotent stem cell-derived cell models to study the effects of those. That is what I would use our money for.   Cindy St. Hilaire:        Well, Dr Mina Chung, Dr DeLisa Fairweather, Dr Milka Koupenova, thank you all so much for joining me today and talking about not only the articles that you wrote and with your colleagues, but also other articles in this amazing compendium. I do think this is one of the first all-encompassing compendiums or group of articles that focus specifically on COVID and cardiovascular disease. So thank you all so much.   Mina Chung:   Thank you.   DeLisa Fairweather:    Thank you.   Milka Koupenova:       You're welcome.   Cindy St. Hilaire:         That's it for highlights from the April 28th and May 12th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @circres and #DiscoverCircRes. Thank you to our guests, Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova. This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2023. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.    

Bloodworks 101
"It was a Big Journey:" The move to 100% apheresis platelets (S4 E23)

Bloodworks 101

Play Episode Listen Later May 4, 2023 19:58


We used to say that you can save three lives with each donation because whole blood can be divided into red cells, platelets, and plasma. This just isn't the case anymore, and that's actually a good thing for local patients and non-profit blood centers like Bloodworks. That's because we now collect 100% of our platelets from apheresis. Vicki Finson and Russ Juntenen in our Blood Services department explain why.

Elimination of the Snakes
Elimination of the Snakes - Show #684

Elimination of the Snakes

Play Episode Listen Later Apr 26, 2023 58:17


Life and political podcast.  Brought to you from The Divided States of America. Some talk about weather... Old fart central... We've been podcasting for years... Hot Topics: Fox News reaches $787.5M settlement with Dominion. All Tuckered out!!! Don Lemon and CNN part ways. The drama king moves on, Goodbye Aaron!!! Yippee!!! Some good news: Donate Blood, Platelets or Plasma. Give Life Videos of the Week: What it means to be Black in America To My Republican Friends… Let's talk about rights, grinding to a halt, and a republican question.... God Gets Salty About Guns Let's talk about Republicans biting the hand that feeds them....

Around the Air Force
Around the Air Force - Oct. 27

Around the Air Force

Play Episode Listen Later Apr 24, 2023


This edition features stories on platelets from Iraq being shipped to Afghanistan, renewing wedding vows, fuel additives and Airmen guarding Joint Base Balad. Hosted by Senior Airman Brad Sisson.

Freedom Watch Update
Freedom Watch Update - Jan. 4

Freedom Watch Update

Play Episode Listen Later Apr 21, 2023


This edition features a story on how blood donations help save the lives of service members in Afghanistan. Produced by Staff Sgt. Toshi Shinzato.

The World of Critical Care

The following episode covers the basics of platelet administration in critical care. The episode focuses on the general function, measurement, and administration of platelets. Platelets have several unique administration requirements that need to be remembered! Next weeks episode will cover the clotting cascade and platelet function in much greater detail. Below are two valuable links to dive into the various causes of thrombocytopenia.  Further reading: https://emcrit.org/ibcc/thrombocytopenia/ Further listening: https://podcasts.apple.com/us/podcast/the-intern-at-work-internal-medicine/id1338378584?i=1000414997402  

Blood and Platelets Podcast
Just F*ckin Survive Today | Paul Goodman chats with Blood and Platelets Podcast

Blood and Platelets Podcast

Play Episode Listen Later Mar 20, 2023 53:17


Paul Goodman, a filmmaker and 2x cancer survivor shares his cancer journey with the Blood and Platelets Podcast. Thank you, Paul for joining us and sharing your amazing story of strength and perseverance with us!

Lab Values Podcast (Nursing Podcast, normal lab values for nurses for NCLEX®) by NRSNG

Get a free nursing lab values cheat sheet at NURSING.com/63labs   What is the Lab Name for Platelets (PLT) Lab Values? Platelets   What is the Lab Abbreviation for Platelets? (PLT)   What is Platelets in terms of Nursing Labs? Platelets (PLT) play a role in coagulation, hemostasis, and thrombus formation. Platelets are the smallest blood cell, damaged vessels send out signals that result in platelets traveling to the area and becoming “active”.   What is the Normal Range for Platelets? 100,000 – 450,000 cells/mcL   What are the Indications for Platelets? Determine clotting vs bleeding disorders   What would cause Increased Levels of Platelets? Malignancy Polycythemia Vera Postsplenectomy syndrome Rheumatoid Arthritis (RA) Iron-deficiency anemia Hemolytic anemia Tuberculosis Birth control   What would cause Decreased Levels of Platelets? Idiopathic Thrombocytopenia (ITP) Inherited thrombocytopenia disorders: Wiskott-Aldrich Syndrome Bernard-Soulier Syndrome Zieve Syndrome Infection: Hepatitis Human Immunodeficiency Virus (HIV) Measles Sepsis Hypersplenism Hemorrhage Leukemia Lymphoma Drug Therapy: Aspirin Ibuprofen Sulfa antibiotics Hydralazine Thiazide diuretics Systemic Lupus Erythematosus (SLE) Hemolytic anemia's

Blood and Platelets Podcast
Blood and Platelets Podcast | Our First Episode Back With Guest, Krishna!

Blood and Platelets Podcast

Play Episode Listen Later Feb 18, 2023 40:15


After a bit of a hiatus, Brandon, Alex and Krissy are back and ready to spread those cancer killing, survivor inspired good vibes. But we're changing it up a bit, expanding our circle beyond our three cancer surviving stories and will be hosting guests each new episode to share their story and experience with the goal of spreading healing vibes and helping others in need of support. Our first guest back is Krishna, who, has a very similar story to Krissy's. You can tell in this episode how much they have in common in terms of their cancer journey, and much they vibed out during the episode. Krishna, thank you for sharing your amazing story. The Blood and Platelets Podcast wishes you strong vibes going into your transplant. CONTACT | Bloodandplateletspodcast@gmail.com INSTAGRAM | @Bloodandplateletspodcast

Bloodworks 101
"Platelet Donation: A Cool Superpower" (S4 E13)

Bloodworks 101

Play Episode Listen Later Jan 26, 2023 15:45


Have you ever donated platelets? Platelets are the part of blood that help control bleeding by collecting at the site of an injury and helping for clots. Kyle Boynton, our Donor Center Collection strategist, wants you to try platelet donation if you haven't. We sat down with Kyle to talk about his work and why this matters so much to patients in the Pacific Northwest. 

American Conservative University
An Empirical Argument for Intelligent Design by Michael Behe and Protein structure cannot evolve by mutations with Douglas Axe and Stephen Meyer.

American Conservative University

Play Episode Listen Later Apr 17, 2022 51:31


An Empirical Argument for Intelligent Design by Michael Behe and Protein structure cannot evolve by mutations with Douglas Axe, Paul Nelson and Stephen Meyer. ACU Sunday Series.    Protein structure cannot evolve by mutations, shows study undercutting Darwin - Axe, Meyer & Nelson https://youtu.be/cFc1yn0VVj4 Solemn Existence Douglas Axe, Paul Nelson and Stephen Meyer discuss intelligent design Full interview https://youtu.be/DwlFgaZkndA     An Empirical Argument for Intelligent Design - Michael Behe Dallas Science Faith Conference 2020 Watch this presentation at- https://youtu.be/24t2eCjPbq4 Discovery Science Professor Michael Behe invites us to review the sweep of his argument for intelligent design, as he has presented it in his books and other publications, form Darwin's Black Box to Darwin Devolves, from irreducible complexity to the First Rule of Adaptive Evolution. This is, from top to bottom, an empirical argument, as he points out. It can only be fairly evaluated on empirical not religious grounds. The annual Dallas Conference on Science & Faith explores exciting scientific discoveries about the origin of the universe, the origin of life, and the development of biological complexity, as well as critiquing the scientific and cultural impact of Darwinism. It also deals directly with the intersection of science and religion and the role that faith plays in scientific research and study. Check out these other videos as well: The Effects of Mutation (Secrets of the Cell with Michael Behe, Ep. 4) https://youtu.be/v9AxqLsKmMA Stephen Meyer Investigates Scientific Evidence for Intelligent Design (Lecture 1) https://youtu.be/C5Z6h_RVhIw Marcos Eberlin on How Foresight Builds on Past Arguments for Intelligent Design https://youtu.be/ssYQX6BZkH0 ============================ The Discovery Science News Channel is the official Youtube channel of Discovery Institute's Center for Science & Culture. The CSC is the institutional hub for scientists, educators, and inquiring minds who think that nature supplies compelling evidence of intelligent design. The CSC supports research, sponsors educational programs, defends free speech, and produce articles, books, and multimedia content. For more information visit https://www.discovery.org/id/ http://www.evolutionnews.org/ http://www.intelligentdesign.org/ Follow us on Facebook and Twitter: Twitter: @discoverycsc Facebook: https://www.facebook.com/discoverycsc/ Visit other Youtube channels connected to the Center for Science & Culture Discovery Institute: https://www.youtube.com/user/Discover... Dr. Stephen C. Meyer: https://www.youtube.com/user/DrStephe... The Magician's Twin - CS Lewis & Evolution: https://www.youtube.com/user/cslewisweb Darwin's Heretic - Alfred Russel Wallce: https://www.youtube.com/user/AlfredRW...   Existence Playlist on Intelligent Design, Darwinism, https://www.youtube.com/watch?v=876GIP6DEVc&list=PL_ux5Q0OYt7tAe9Y3yp310QrJXS8kpN1K --------------------------------------------------------------------  HELP ACU SPREAD THE WORD!   Ways to subscribe to the American Conservative University Podcast Click here to subscribe via iTunes Click here to subscribe via RSS You can also subscribe via Stitcher If you like this episode head on over to iTunes and kindly leave us a rating, a review and subscribe! People find us through our good reviews.   FEEDBACK + PROMOTION You can ask your questions, make comments, submit ideas for shows and lots more. Let your voice be heard. Email us at americanconservativeuniversity@americanconservativeuniversity.com Note- ACU Students and Alumni are asked to commit to donating Platelets and Plasma.  Make an Appointment Today! Call Your local Hospital or The Red Cross at 1-800-733-2767