Podcasts about semaglutide

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Best podcasts about semaglutide

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Latest podcast episodes about semaglutide

Docs Who Lift
GLP-1 meds and macular degeneration

Docs Who Lift

Play Episode Listen Later Jun 23, 2025 33:33


Learn what age-related macular degeneration (AMD) isWhat causes AMDThe types of AMDThe update on NAION - listen to last year's podcast all about itWhy we aren't too concernedClick here to join Dr. Spencer's online clinic VineyardClick to read the JAMA AMD articleClick to read the Ophthalmology journal AMD article

Balls Deep
How This Marine Veteran Fixed His Low Testosterone & Chronic Stress (My TRT Journey)

Balls Deep

Play Episode Listen Later Jun 19, 2025 27:57


Feeling stressed, fatigued, or like you've lost your edge? It's likely your hormones. In this episode, Marine Corps veteran and entrepreneur Micah Berg reveals his exact protocol for reversing burnout with Testosterone Replacement Therapy (TRT) and cutting-edge peptide treatments.    Ready to take control? Download our FREE Hormone Optimization Guide to start boosting your T levels and regaining your energy today: https://pazonamd.com/Hormone_Lifestyle_eBook_V3-24.pdf   Micah's story is a powerful, unfiltered look at how the immense pressure of being an entrepreneur, veteran, and family man can tank your testosterone and spike your cortisol. But more importantly, he shares the specific steps he took to reclaim his health, energy, and drive.   If you've ever wondered about hormone optimization, this is the episode you can't afford to miss.   -- IN THIS EPISODE, WE DISCUSS --  The silent symptoms of chronic stress and low testosterone most men ignore.  The critical link between high cortisol (stress hormone) and low T.  A real-world comparison of TRT options: pellets vs. injections vs. creams.  Micah's personal experience and results with peptide therapies like Semaglutide. Actionable steps you can take to start your own health transformation journey.

The Peptide Podcast
5-Amino-1MQ

The Peptide Podcast

Play Episode Listen Later Jun 19, 2025 6:03


Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Today, we're taking a close look at 5-Amino-1MQ—a compound gaining attention for its potential to improve fat loss, metabolic health, and longevity. We'll break down how it works, the science behind it, and what that could mean for your health. Let's get started. So, What Is 5-Amino-1MQ? Now, just to clear something up—5-Amino-1MQ isn't actually a peptide. A lot of people assume it is because it's often talked about alongside peptides like semaglutide or BPC-157, but it's actually a small molecule compound. Its full name is 5-Amino-1-methyl-quino-linium—yeah, a bit of a mouthful—and it's designed to block an enzyme called NNMT. By doing that, it helps keep more NAD⁺ available in your cells, which is a big deal for energy production and metabolic health. It was originally developed in the world of metabolic research. Scientists were exploring ways to improve insulin sensitivity and reduce fat accumulation—especially the dangerous kind, visceral fat. So, while it plays in the same space as peptides when it comes to benefits—like fat loss, energy, and longevity—it's a totally different kind of compound. Think of it more like a targeted metabolic activator than a signaling peptide. Before we move on, I want to talk about visceral fat for a bit.  Visceral fat is the fat that builds up deep inside your abdomen, around your internal organs like your liver, pancreas, and intestines. It's different from the fat you can pinch under your skin—like on your belly or thighs. That's called subcutaneous fat. Now, why is visceral fat a problem? Because it's metabolically active, which means it doesn't just sit there—it releases hormones and inflammatory chemicals that can mess with your body's systems. High levels of visceral fat are linked to things like insulin resistance, high cholesterol, high blood pressure, and a greater risk of type 2 diabetes, heart disease, and even certain cancers. So even if someone looks slim on the outside, having too much visceral fat on the inside can still be dangerous for their health. *What Is NNMT and Why Do We Want to Block It? Let's Talk About The Science. NNMT stands for nicotinamide N-methyltransferase.  This enzyme tends to be more active in people who are overweight or have metabolic issues. When that happens, it uses up a lot of something called NAD⁺—a compound your cells need to create energy, especially in the mitochondria, which are like the power plants of your cells. So when NNMT levels go up, here's what tends to happen: You end up with less NAD⁺, your metabolism slows down, your body stores more fat, and your cells just don't have the same energy or resilience. That's where 5-Amino-1MQ comes in. It blocks NNMT, helping your cells hold onto more NAD⁺—and that changes everything. The Metabolic Benefits of Blocking NNMT *So what happens when you increase NAD⁺ inside your cells? Well, in studies—especially in animal models—5-Amino-1MQ led to: Fat breakdown and reduced fat accumulation Improved insulin sensitivity A 30% drop in cholesterol levels And get this—mice lost 5% of their body weight in just 11 days, without changes to diet or exercise. And here's the kicker—no signs of toxicity or behavioral changes. No weird side effects. Just better metabolic function. Muscle Preservation & Longevity Pathways *One of the most promising things about 5-Amino-1MQ goes beyond fat loss—it's what it could mean for preserving muscle. Blocking NNMT might actually help you keep your muscle while you're losing fat. That's a big deal—especially if you've ever tried to drop weight and felt like you were losing strength along with it. This is important because most weight loss methods cause you to lose both fat and muscle, which can slow your metabolism and reduce strength. Preserving muscle while burning fat helps you maintain energy, performance, and long-term metabolic health. There's also some solid evidence it can boost muscle performance and endurance, which tracks when you think about how it raises NAD⁺. And because NAD⁺ is involved in things like cell repair, mitochondrial function, and longevity pathways like sirtuin activation, you're not just burning fat—you're potentially supporting healthy aging and helping your body work more efficiently overall. Oral vs Injectable 5-Amino-1MQ: What's the Difference? People often ask me, “Should I take 5-Amino-1MQ as a pill or go with injections?” Here's the deal, the injectable version gets into your system faster and starts working a bit quicker. On the other hand, the oral version takes a little longer to kick in, but it's way more convenient—just take a capsule and you're good. No needles, no fuss. And honestly? Most people say they feel the same benefits either way—whether it's fat loss, energy, or mood. So unless you're looking for super fast absorption, oral works great for most people. Wrapping It Up: Why This Matters To recap—5-Amino-1MQ helps: Boost NAD⁺ levels Shrink visceral fat tissue Improve insulin sensitivity and cholesterol Preserve muscle mass during weight loss Enhance endurance Activate longevity pathways And it does it by blocking an enzyme that works against you—NNMT. This isn't magic—it's smart metabolic science. And it might just be the edge you need if you're hitting a plateau or looking to optimize how your body performs, heals, and ages. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!  

The Body Reimage Podcast
EAA - The essential supplement for all GLP-1 users that helps preserve muscle while dieting!

The Body Reimage Podcast

Play Episode Listen Later Jun 18, 2025 34:32


Part informative, part a shameless plug for Dr. Seltzers very own product, Apex RX. Find out how adding Essential Amino Acids to your menu can boost results. What are EAA's, what to look for when buying, when to take, and what the benefits are.    APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com      

Last Week in Medicine
Semaglutide for CVD in Diabetes, PAD, and MASH, Semaglutide vs Tirzepatide, Normal Saline vs Lactated Ringer's, Oxygen Targets for Intubated Patients, Platelet Transfusion Guidelines, Apixaban vs Rivaroxaban

Last Week in Medicine

Play Episode Listen Later Jun 17, 2025 65:06


Today we do a round-up of some of the recent semaglutide trials. Does semaglutide ever miss? But what about tirzepatide, which causes even more weight loss?We also review two new critical care trials, FLUID and the UK-ROX, new platelet transfusion guidelines, and a new retrospective study of apixaban vs rivaroxaban vs warfarin. Oral Semaglutide for Diabetes with Cardiovascular Disease or CKD (SOUL)Semaglutide for Peripheral Artery Disease (STRIDE)Semaglutide for MASH (ESSENCE)Semaglutide vs Tirzepatide for Obesity (SURMOUNT-5)Normal Saline vs Lactated Ringers (FLUID)Conservative Oxygen Targets in Mechanically Ventilated Patients (UK-ROX)Platelet Transfusion GuidelinesApixaban vs Rivaroxaban vs Warfarin Music from Uppbeat (free for Creators!): https://uppbeat.io/t/soundroll/dope License code: NP8HLP5WKGKXFW2R

FORward Radio program archives
Bench Talk | Side Effect of Injectable Weight-Loss Drugs - Louisville Physician Speaks Out | June 16, 2025

FORward Radio program archives

Play Episode Listen Later Jun 17, 2025 28:59


Semaglutide medicines for treating diabetes and obesity (like Ozempic, Wegovy and Mounjaro) have recently been observed to make mice more sedentary. Will these drugs have the same effect on humans? And how were semaglutides discovered, and what does that say about public financing of basic research? Finally, Dr. Bruce A. Scott, a Louisville physician and outgoing President of the American Medical Association gave a fiery address to the association on June 6th. What was he angry about? Here is the full video of Dr. Scott's talk to the AMA: https://www.youtube.com/watch?v=XIEy5ySMDHE ‘Bench Talk: The Week in Science' is a weekly program that airs on WFMP Louisville FORward Radio 106.5 FM (forwardradio.org) every Monday at 7:30 pm, Tuesday at 11:30 am, and Wednesday at 7:30 am. Visit our Facebook page for links to the articles discussed in this episode: https://www.facebook.com/pg/BenchTalkRadio/posts/?ref=page_internal

Inside the Cure with Dr. Charles Mok
Semaglutide and Hormone Replacement Therapy For Weight Loss

Inside the Cure with Dr. Charles Mok

Play Episode Listen Later Jun 17, 2025 12:24


Book your Semaglutide injections session with Allure Medical.https://www.alluremedical.com/services/semaglutide-weight-loss/ Can semaglutide and hormone replacement therapy (HRT) be used hand-in-hand for weight loss?In this episode, Dr. Charles Mok walks us through the effectiveness of semaglutide and hormone replacement therapy in supporting medical weight loss.He explains how semaglutide, a GLP-1 receptor agonist, can aid individuals with diabetes in managing weight and examines the connection between obesity and diabetes. He also discusses optimal dosing, strategies to increase effectiveness, and whether hormone replacement therapy contributes to weight loss when used with GLP-1.Tune in to Inside The Cure Podcast — Semaglutide and Hormone Replacement Therapy For Weight LossSubscribe to Inside the Cure on Apple Podcasts and leave a 5-star review! https://podcasts.apple.com/us/podcast/inside-the-cure-with-dr-charles-mok/id1495870043?uo=4Read the latest research and advice from the doctors at Allure Medical: https://www.alluremedical.com/books/ Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/ Instagram: https://www.instagram.com/alluremedicals/ Website: https://www.alluremedical.com/ YouTube: https://www.youtube.com/@AllureMedical TikTok: https://www.tiktok.com/@alluremedical  Amazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true Join the Allure Medical Inner Circle Membership:https://www.alluremedical.com/inner-circle-membership/ 

Trensparent with Nyle Nayga
Dr. Dean: Health & Steroids - Avoiding Death to Sleep to Hair Restoration

Trensparent with Nyle Nayga

Play Episode Listen Later Jun 15, 2025 203:25


PhD in synthetic chemistry, the Product Formulator for Supplement Needs, and fitness industry renowned Pharmacologist for his no-nonsense approach in bodybuildingThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com2:19 Bodybuilding Pharmacology and Dosing4:53 Brain Health and Long-Term Risks7:29 Muscle Building and Genetic Factors10:03 Cholesterol and LDL Impacts12:14 Podcast Setup and Equipment Upgrades14:34 Hair Transplant Journey24:23 Hair Loss Causes and Treatments34:59 Post-Transplant Recovery and Rebound39:31 Epigenetics and Muscle Memory43:04 Ethical Questions on Genetic Enhancement45:40 Enhanced Games Debate50:09 Dosing Challenges in Enhanced Sports52:32 Data Collection and Human Experimentation55:16 Genetic Variance and Elite Athletes59:04 Neurodegeneration and PEDs1:07:08 Oxidative Stress in Bodybuilding1:09:37 Sleep and Brain Detox1:18:01 Nutrition for Oxidative Stress1:19:02 Melatonin as an Antioxidant1:21:13 Melatonin Dosing and Effects1:24:51 Melatonin and Sleep Support Supplements1:28:22 Magnesium and Sleep Health1:31:23 Sleep Apnea and Neural Health1:36:30 Frequent Urination at Night1:46:33 Overheating During Sleep1:59:14 Wrapping Up Oxidative Stress2:00:33 Neuron Loss and Neurotransmitters2:02:04 Boosting Brain Health with BDNF2:04:08 Peptides for Neural Growth2:09:14 Oxidative Stress and Supplements2:12:34 Neuroprotection Strategies2:19:56 EMF and Environmental Stressors2:22:12 Mitochondrial Dysfunction and Aging2:24:55 Balancing Oxidative Stress2:28:32 Steroids and Muscle Growth Rates2:38:54 HDL and LDL Control Ancillaries2:41:34 Statins and LDL Oxidation2:47:36 Antioxidants and Plaque Formation2:54:10 Balancing Cholesterol Levels2:58:35 CT Scans for Heart Health3:03:54 Heart Health Supplements3:06:48 Mitochondrial Stack Under 303:16:27 Balanced Diet in Prep3:20:24 Omega-3 and Fish Oil Quality3:23:36 Podcast Wrap-Up

CCO Medical Specialties Podcast
Quality Improvement in Obesity Care: How to Develop Patient-Centered and Tailored Treatment Plans

CCO Medical Specialties Podcast

Play Episode Listen Later Jun 13, 2025 27:07


Listen in as Joseph Kim, MD, MPH, MBA, interviews Natalie, Orbach, PA-C, to learn about how she implemented patient-centered and individualized treatment plans to improve obesity care at her practice, includingDiscussing weight and how nutrition, physical activity, mental health, and pharmacotherapy strategies can helpMeeting patients where they are at and offering slow, incremental changes that support long-term outcomesReferring patients to community resources and other professionals as needSharing lessons learned for those interested in implementing similar strategies in their practice PresenterJoseph Kim, MD, MPH, MBAPresidentQ Synthesis, LLCNewtown, PennsylvaniaNatalie Orbach, PA-CPhysician AssistantFeirtag & Ramos, PALutherville, Maryland Link to full program: https://bit.ly/45P0v8z

The Peptide Podcast
Breaking Through GLP-1 Weight Loss Plateaus

The Peptide Podcast

Play Episode Listen Later Jun 12, 2025 11:31


Welcome to The Peptide Podcast. Today we're going to talk about something that almost everyone on a GLP-1 journey hits eventually, the weight loss plateau. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  It starts like this: you begin a GLP-1 like semaglutide or tirzepatide, and for the first few weeks or months, the weight seems to fall off. You're eating less, not obsessing over food, and for the first time in a long time, it feels… easy. Then one day, the scale just stops moving. You're not doing anything different. You're still taking the meds. Still trying to eat well. Maybe you're walking more or lifting weights. But suddenly, nothing's happening—and the frustration kicks in. Sound familiar? Let's talk about what's really going on. 1. What Causes the Plateau? First of all, if you're in this place right now: you didn't mess up. GLP-1s are incredibly effective at reducing appetite and creating an initial calorie deficit, which is why people lose weight so quickly in the beginning. But your body isn't just going to let that continue unchecked. It adapts. This is called adaptive thermogenesis—a fancy way of saying your body becomes more efficient. You start burning fewer calories at rest than you did before. Your resting metabolic rate actually drops beyond what you'd expect just from losing weight alone. It's a survival mechanism. So what worked at the beginning—eating less and moving a bit more—might no longer be enough to keep the scale moving. This is totally normal.  2. Metabolism & Muscle: Why Strength Training Matters Now More Than Ever So now that we know why the plateau happens, let's talk about things we can do to help us get over it. Something that often gets overlooked but is absolutely critical—especially if you're on a GLP-1 or in any kind of calorie deficit. Resistance training is not optional. It's non-negotiable. Here's why. When you're losing weight—whether it's from a medication like semaglutide or just eating in a calorie deficit—your body isn't just pulling energy from fat. If you're not careful, it's also going to break down lean muscle tissue. And the more muscle you lose, the slower your metabolism gets. Why? Because muscle is metabolically active tissue. It burns calories even when you're doing absolutely nothing. So if you're not actively sending a signal to your body to keep that muscle, it'll start to let it go. That's where resistance training comes in. When you lift weights or do bodyweight exercises—think squats, push-ups, resistance bands, even heavy housework—you're telling your body: “Hey, I need this muscle. Don't burn it for fuel.” This is especially important for those on GLP-1s because these meds reduce appetite so significantly that you might not be eating enough protein—or enough calories in general—to maintain muscle without that extra stimulus. So if you've hit a plateau or want to prevent one, ask yourself: Am I strength training at least two to three times a week? Am I prioritizing movements that challenge large muscle groups—like legs, glutes, chest, and back? Am I fueling my workouts with enough protein? And let me be really clear, you don't have to become a gym rat. You don't have to lift crazy heavy weights. But you do have to move your muscles in a meaningful, consistent way. Protecting your lean mass is one of the best ways to keep your metabolism humming—not just during your weight loss journey, but after it too. Because this isn't about just losing weight—it's about building a strong, metabolically healthy body that can maintain that weight loss for life. 3. Mindset Check: The Plateau Is Not a Failure Now, let's get into the mental side of this journey—because it's just as important as nutrition, movement, and medication. One of the biggest challenges people face—especially when progress slows—is the mental roller coaster that comes with watching the scale. And I'll be honest: weighing yourself every single day is not ideal. Here's why. Your body weight naturally fluctuates. Daily. And those fluctuations have nothing to do with your actual fat loss or long-term progress. Instead, the number on the scale is influenced by things like: Hydration status – If you're slightly dehydrated, the scale may dip. But if you drank a ton of water the day before or had more salty food, it may go up due to water retention. Glycogen stores – When you eat carbs, your body stores them in your muscles and liver as glycogen, and for every gram of glycogen, your body stores about 3–4 grams of water. So a pasta dinner or even a healthy grain bowl can cause a temporary increase on the scale. Digestive contents – Let's be real: if you haven't had a bowel movement (constipation) or just ate a bigger meal, the scale might reflect that. Doesn't mean you gained fat. Inflammation or illness – If you're recovering from an illness, injury, or even a hard workout, your body retains extra water as part of the healing process. Again—temporary. But here's what happens when we don't understand this, we step on the scale, see a higher number, and panic. We question everything—“Am I doing something wrong? Is the medication not working? Should I eat less?” And that mindset spiral can lead to unnecessary stress, restriction, or even giving up. So what should you do instead? Focus on trends over time, not daily weigh-ins. Weigh yourself once a week at most, ideally at the same time of day, under the same conditions (like first thing in the morning before food or water). Or better yet—track non-scale victories: clothes fitting better, improved energy, reduced cravings, less inflammation, better digestion, even clearer skin. These are all signs your body is healing and progressing. Remember, your worth is not defined by a number, and fat loss is not always linear. There are ups, downs, pauses, and breakthroughs—and all of them are part of the process. 4. Habits: Recheck Your Routine Now, here's where we get really honest. Because as the months go by, it's normal for habits to loosen up. Maybe you're not tracking portions quite as closely. Maybe your steps have dropped. Maybe “just a bite” here and there has crept in more often than you realize. This doesn't make you bad or lazy—it makes you human. But if progress has stalled, it's worth revisiting the basics: Are you eating mostly whole, minimally processed foods? Are you staying hydrated and watching added sugars? Are you eating out frequently without paying attention to portions? Are you still moving your body every day? Small shifts can make a big difference. 5. Food Noise: Why It's Sneaking Back One of the most exciting things about GLP-1s is how much they reduce food noise—that constant mental chatter about snacks, cravings, and what's in the fridge. But for many people, that quiet doesn't last forever. Over time, especially as your body adapts to the medication or your dose levels off, food noise can return. You might find yourself thinking about food more often or wanting things you weren't craving before. This doesn't mean the med has stopped working. It means your biology is adjusting. What helps: Keeping meals protein-forward and fiber-rich Eating at regular times to avoid dips in energy or blood sugar Identifying emotional vs. physical hunger Managing stress and sleep, which both drive cravings This is the time to build real strategies—so you're not relying on the med alone. 6. Emotional Eating This brings me to my next point. Let's talk about something that often flies under the radar but can make a huge difference in your weight loss journey—emotional eating. This is when feelings like stress, boredom, anxiety, or sadness trigger you to eat, even if you're not physically hungry. It's totally normal, and many people experience this at some point. Now, GLP-1 medications like semaglutide or tirzepatide do a great job at reducing physical hunger by influencing hormones that control appetite. But they don't always fully address the emotional side of eating. So, even if your stomach feels satisfied, those emotional triggers can still push you toward cravings or eating for comfort. Recognizing emotional eating is the first step. Try to notice when you're eating because of feelings rather than hunger. Strategies like mindful eating, journaling your emotions, or finding alternative outlets—like walking, meditation, or chatting with a friend—can really help. If emotional eating is a big hurdle, working with a therapist or counselor who specializes in behavioral health can provide tools to manage those feelings without turning to food. Remember, managing emotional eating alongside your GLP-1 treatment can make a huge difference in overcoming plateaus and reaching your goals more sustainably. 7. Set Realistic Expectations: Fat Loss Isn't Linear Lastly, I want to talk about setting realistic expectations. I can't stress the following enough. You are not supposed to lose weight every single week forever. Your body needs breaks. Your metabolism needs to reset. And your mind needs time to adapt to this new version of you. Think of your fat loss journey like a staircase—not a slide. There are flat spots before the next drop. And guess what? Some of the most important changes—like maintaining your weight, building strength, or stabilizing your habits—happen during those flat spots. You don't need to push harder or go more extreme. You just need to keep showing up consistently. My Final Thoughts: Trust the Process The bottom line is trust the process. If you're on a GLP-1 and the scale has stalled, take a deep breath. This is a normal part of the process. It's not the end—it's just a signal to pivot and refocus. We want to build muscle. Prioritize protein. Revisit your habits. Stay active. And most importantly, don't give up. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!

PVRoundup Podcast
Can increased physical activity after adjuvant therapy for colon cancer improve disease-free survival?

PVRoundup Podcast

Play Episode Listen Later Jun 11, 2025 6:17


The CHALLENGE trial at ASCO 2025 showed that increased physical activity improves survival rates in colon cancer patients, with the exercise group demonstrating better health outcomes and survival rates compared to those receiving only health education. A phase 3 trial in The New England Journal of Medicine found that semaglutide significantly improves liver conditions in MASH patients, showing better resolution of steatohepatitis and fibrosis improvement compared to placebo. Additionally, a study in the NEJM revealed that combining finerenone and empagliflozin offers enhanced kidney protection in patients with chronic kidney disease and type 2 diabetes, significantly reducing urinary albumin levels.

Aesthetically Speaking
The Lessons I Learned Scaling My Practice

Aesthetically Speaking

Play Episode Listen Later Jun 11, 2025 31:52


Since Dr. Tiffany McCormack began her practice with just a few employees, she's grown into a full team offering everything from lasers and injectables to vaginal rejuvenation in a 12,000-square-foot facility featuring a surgery center and a medical spa.Scaling up is not without growing pains. From a close-knit team of 2 or 3 to a staff of 30, building the right company culture is the key to success. Opening up about navigating the competitive world of aesthetics, her focus on quality care and strong community connections makes her practice stand out. As co-chair of Hot Topics for The Aesthetic Society, Dr. McCormack gives us a peek into what's trending right now, from the wellness boom in aesthetics and skin-rejuvenating exosomes to next-gen breast implants like Motiva and cutting-edge procedures like rib remodeling.About Dr. Tiffany McCormackAs the proud mother of two young children, Dr. Tiffany McCormack knows what a gift it is to become a mom. As a distinguished plastic surgeon, she knows the physical rigors that the body goes through during pregnancy and how to reverse their effects. She has helped many patients in the Reno, Nevada and Lake Tahoe, California areas to enjoy the best of both worlds—the joy of having children and the confidence that comes from looking and feeling your best.Learn more about Reno plastic surgeon Dr. Tiffany MCormackFollow Dr. McCormack on Instagram @drtiffanymccormackGuestTiffany McCormack, MDReno Tahoe Plastic SurgeryHostRobin Ntoh, VP of AestheticsNextechPresented by Nextech, Aesthetically Speaking delves into the world of aesthetic practices, where art meets science, and innovation transforms beauty.With our team of experts we bring you unparalleled insights gained from years of collaborating with thousands of practices ranging from plastic surgery and dermatology to medical spas. Whether you're a seasoned professional or a budding entrepreneur, this podcast is tailored for you.Each episode is a deep dive into the trends, challenges, and triumphs that shape the aesthetic landscape. We'll explore the latest advancements in technology, share success stories, and provide invaluable perspectives that empower you to make informed decisions.Expect candid conversations with industry leaders, trailblazers and visionaries who are redefining the standards of excellence. From innovative treatments to business strategies, we cover it all.Our mission is to be your go-to resource for staying ahead in this ever-evolving field. So if you're passionate about aesthetics, eager to stay ahead of the curve and determined to elevate your practice, subscribe to the Aesthetically Speaking podcast.Let's embark on this transformative journey together where beauty meets business.About NextechIndustry-leading software for dermatology, medical spas, ophthalmology, orthopedics, and plastic surgery at https://www.nextech.com/ Follow Nextech on Instagram @nextechglow

The Well
Weight Loss Drugs: Starting, Stopping And The Surprising Side Effects

The Well

Play Episode Listen Later Jun 11, 2025 32:56 Transcription Available


How do weight loss injections work and does the weight pile on again when you stop them? You’ve heard about your G-spot but what about your A-spot and your O-spot ? And how to deal with a phobia of needles. In this episode, Bariatrician GP Dr Jessica McEwan talks about the potential benefits and risks of GLP-1 agonists including what happens if you take too much. We also discuss how to talk to your GP to find out if you meet the appropriate guidelines for prescription and how lifestyle changes including diet and exercise are crucial to their success. Also, we talk about how the food industry is trying to make ultra-processed foods even more addictive to override the effects of these drugs. Ask The Doc: Ask us a question in The Waiting Room. Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can email well@mamamia.com.au, send it anonymously here, email here or leave us a voice note here. THE END BITS Follow us on Instagram and Tiktok. All your health information is in the Well Hub. Support independent women’s media by becoming a Mamamia subscriberCREDITS Hosts: Claire Murphy and Dr Mariam Guest: Dr Jessica McEwan Senior Producers: Claire Murphy and Sasha Tannock Audio Producer: Scott Stronach Video Producer: Julian Rosario Mamamia studios are styled with furniture from Fenton and Fenton. Visit fentonandfenton.com.au Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.Support the show: https://www.mamamia.com.au/mplus/See omnystudio.com/listener for privacy information.

The Other Side of Weight Loss
Quick Hits: Separating Fact from Fiction: Everything You Need to Know About The Weight Loss Medications Ozempic (Semaglutide) and Monjauro (Tirzepatide)

The Other Side of Weight Loss

Play Episode Listen Later Jun 10, 2025 33:20


In this quick hits episode, you are going to hear a clip from my most downloaded episode to date! I take a deep dive into the world of GLP-1s, the revolutionary weight loss medications that have captivated the health and wellness scene. We all know that whenever there's a new breakthrough, doubts and controversies tend to emerge, leaving us wondering if it's too good to be true. But fear not! In this show, I am here to unravel the mysteries and shed light on these drugs like never before. My goal is to address your concerns, provide clarity, and empower you with the knowledge to make informed decisions. I will share my own journey on tirzepatide plus client experiences. Whether you're considering these medications or simply seeking accurate information, this episode will be your ultimate resource. So sit back, relax, and join me on this captivating journey into the realm of GLP-1s. By the end of this podcast, you'll have a comprehensive understanding of the pros and cons, equipping you with the insights to navigate this topic with confidence. It's time to separate the facts from the myths and arm yourself with the information you need. Listen to the full episode here.   Sponsors Get $100 off your CAROL bike with coupon code HORMONE here.     Are you in peri or post menopause and looking to optimize your hormones and health? At Hormone Solutions, we offer telemedicine services and can prescribe in every U.S. state, as well as in British Columbia, Alberta, and Ontario in Canada.   Visit karenmartel.com to explore our comprehensive programs: Bioidentical Hormone Replacement Therapy Individualized Weight Loss Programs  Peptide Therapy for weight loss    Interested in our NEW Peptide Weight Loss Program? Join today and get all the details here.   Join our Women's Peri and Post Menopause Group Coaching Program, OnTrack, TODAY!   To our nursing audience members, our podcasts qualify for nursing CE @ RNegade.pro. Provide # CEP17654.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

The Clay Edwards Show
TALKING MEN'S HEALTH, TESTOSTERONE, SEMAGLUTIDE, PEPTIDES & MORE W/ DR. MICAH WALKER P.H.D

The Clay Edwards Show

Play Episode Listen Later Jun 10, 2025 70:38


The Clay Edwards Show Live at Men's Health & Women's Wellness of Mississippi Join us for an engaging and informative special live edition of The Clay Edwards Show, broadcast directly from the lobby of Men's Health & Women's Wellness of Mississippi, located at 120 Fountains Boulevard, Madison, MS. Host Clay Edwards sits down with Dr. Micah Walker for an in-depth conversation about men's and women's health, covering a wide range of topics from testosterone therapy and weight loss to innovative treatments and the importance of proactive healthcare. In this episode, Clay and Dr. Walker dive into the transformative benefits of semaglutide and tirzepatide, GLP-1 agonist medications known for their effectiveness in weight loss. They discuss how these drugs not only aid in shedding pounds but also help curb alcohol cravings and improve mental relationships with food by targeting the brain's dopamine reward center. Clay shares personal anecdotes about his own health journey, including how semaglutide has helped him manage cravings and maintain a healthier lifestyle, while Dr. Walker provides expert insights into the science behind these medications and their potential future FDA indications for addiction treatment.   The conversation also explores the critical role of testosterone therapy, particularly for men experiencing low levels due to age, lifestyle, or medical conditions. Dr. Walker emphasizes the importance of identifying the root cause of low testosterone through comprehensive blood work, highlighting conditions like sleep apnea, obesity, or past use of anabolic substances that can contribute. He addresses common concerns about testosterone therapy for older men, debunking myths and explaining its safety and benefits when medically supervised. The discussion extends to younger men with low testosterone, with Dr. Walker advocating for a thorough evaluation to determine whether lifestyle changes or medical intervention is the best course.   Clay and Dr. Walker also tackle the controversial topic of peptides, addressing the hype surrounding these compounds in fitness and anti-aging circles. Dr. Walker cautions against the use of unregulated peptides like melanotan and SARMs, sharing a sobering story of a patient who suffered severe complications from an unsafe source. He stresses the importance of sticking to FDA-approved treatments from reputable sources, such as brand-name medications or trusted compounding pharmacies, to ensure safety and efficacy.   Beyond men's health, Dr. Walker introduces the services offered at Women's Wellness of Mississippi, located upstairs in the same facility. This concierge primary care clinic caters to women aged 30-65, offering annual wellness exams, hormone therapy, weight loss programs, and aesthetic treatments like Botox, fillers, laser hair removal, and medical-grade skincare with ZO Skin Health. Innovative devices like the Emsculpt Neo (equivalent to 20,000 sit-ups in 30 minutes) and Emsella (for stress incontinence) are highlighted as non-invasive solutions for women looking to reclaim their health and confidence post-childbirth or as they age.   The episode underscores the clinic's unique approach to healthcare, designed to fit the busy lives of men and women. Men's Health & Women's Wellness of Mississippi offers a membership-based model with no long-term contracts, providing affordable, transparent pricing and minimal wait times. Clay shares how this model has been a game-changer for him as a self-employed individual, combining a high-deductible insurance plan with the clinic's membership for cost-effective, accessible care. Dr. Walker explains how the clinic serves as a primary care provider, managing conditions like diabetes, hypertension, and sleep apnea, and fostering a comfortable, judgment-free environment for patients to discuss sensitive issues, including erectile dysfunction, with affordable solutions like generic Viagra and Cialis.   Throughout the episode, Clay and Dr. Walker address broader healthcare issues, from the complexities of the pharmaceutical industry to the loss of trust in medical institutions post-COVID. They discuss the importance of patient choice, the risks of unverified online supplements, and the need for honest, transparent communication between doctors and patients. The episode wraps up with a call to action for viewers to prioritize their health, emphasizing the clinic's welcoming atmosphere—complete with deer heads, a leg lamp, and a “reception area” rather than a traditional waiting room.   For more information or to schedule a visit, check out MensHealthMS.com or call 1-844-4MVPTRT. Don't miss this lively, candid discussion packed with practical health insights and a behind-the-scenes look at a clinic reimagining healthcare for men and women in Madison, Mississippi.   Note: This episode was recorded on June 10, 2025, and reflects the latest services and perspectives from Men's Health & Women's Wellness of Mississippi.

Medical Portfolio Podcast
Medical Portfolio Podcast: Best of the Month - May 2025

Medical Portfolio Podcast

Play Episode Listen Later Jun 10, 2025 18:04


Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks.This month we're discussing:Antihypertensive Medication Timing and Cardiovascular Events and Death; The BedMed Randomized Clinical TrialDOI: 10.1001/jama.2025.4390Tirzepatide as Compared with Semaglutide for the Treatment of ObesityDOI: 10.1056/NEJMoa2416394Randomized, Placebo‐Controlled, Triple‐Blind Clinical Trial of Ivabradine for the Prevention of Cardiac Dysfunction During Anthracycline‐Based Cancer TherapyDOI: 10.1161/JAHA.124.039745Scientific team:Ricardo Ladeiras Lopes, Mário Santos and João Sérgio NevesDiscover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://linktr.ee/medicalportfolioapp⁠

Back on Track: Overcoming Weight Regain
Episode 203: From Shots to Swallow: The Future of Weight Loss with Oral Semaglutide

Back on Track: Overcoming Weight Regain

Play Episode Listen Later Jun 9, 2025 13:35


Did you know a daily weight loss pill might soon replace weekly injections for managing obesity? In this episode, I explore the exciting new development of a once-daily oral weight loss medication, oral semaglutide 50mg highlighting results from the OASIS 1 trial. With this, I explain how this pill could be a game-changer for people who are hesitant about injections like Wegovy or Zepbound. I break down how semaglutide works as a GLP-1 receptor agonist, the phases of drug development, and the impressive trial results showing an average 15% body weight loss in participants without diabetes. I also talk about common side effects, the FDA approval timeline, and what this could mean for patients looking for more accessible, convenient weight loss options. Curious about the future of weight loss treatments? Tune in to learn about a groundbreaking pill that could change everything.   Episode Highlight: Introduction of oral semaglutide 50mg as a potential weight loss pill  Explanation of how semaglutide works as a GLP-1 receptor agonist. Overview of the OASIS 1 phase 3 trial Breakdown of clinical trial phases and FDA approval process. Discussion of side effects Adherence rates and significant weight loss among participants. Insight into future FDA approval timelines and potential market release Importance of combining medication with lifestyle changes Considerations about insurance coverage and patient access   Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd   About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.   Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)

Plant Based Briefing
1076: The Tofu Era Is Upon Us: How This Ancient Protein Is Redefining Clean Eating by the VegNews Editors at VegNews.com

Plant Based Briefing

Play Episode Listen Later Jun 9, 2025 9:56


The Tofu Era Is Upon Us: How This Ancient Protein Is Redefining Clean Eating As consumers push back on ultra-processed foods, tofu is making a comeback as the go-to clean protein—especially for GLP-1 users and wellness-minded eaters. Listen to today's episode written by the VegNews Editors at VegNews.com #vegan #plantbased #plantbasedbriefing #UPFs, #ultraprocessedfoods #semaglutide #glp1 #ozempic #wegovy #tofu #maha #protein #cleanprotein #plantprotein ========================== Original post: https://vegnews.com/tofu-era-clean-protein  Related Episodes: FREE 1-HR TOFU MASTERCLASS REPLAY (different types, health benefits, and ways to prepare it):  https://veganfamilykitchen.com/tofu-masterclass/  758: [Part 2] Tofu: What it Really Is and How to Enjoy It https://plantbasedbriefing.libsyn.com/758-part-2-tofu-what-it-really-is-and-how-to-enjoy-it-by-brigitte-gemme-at-veganfamilykitchencom  757: [Part 1] Tofu: What it Really Is and How to Enjoy It https://plantbasedbriefing.libsyn.com/757-part-1-tofu-what-it-really-is-and-how-to-enjoy-it-by-brigitte-gemme-at-veganfamilykitchencom  Related Episodes: Search for “soy”, “tofu” using search feature at https://www.plantbasedbriefing.com/episodes-search    ======================== Launched in 2000, VegNews is the largest vegan media brand in the world. They have a best-selling plant-based magazine, and they create amazing content from food and fashion to travel, celebrity interviews, beauty and health info, a meal planner, and vegan travel excursions. Their Guide section on their website is full of great information and they have an online shop where you can find cookbooks, foods, kitchen tools, vegan meal delivery services. They also have a website, VeganWeddings.com. Please visit www.VegNews.com for a wealth of resources.  ======================== FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866 Facebook: https://www.facebook.com/PlantBasedBriefing   LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/     

Trensparent with Nyle Nayga
The Guerrilla Chemist: Drugs, Peptides, & Supplements That Actually Work

Trensparent with Nyle Nayga

Play Episode Listen Later Jun 8, 2025 186:42


Bryan Moskow: MS Organic & Biochemistry UCF/GT, PhD Student at Georgia Tech, Offseason/Prep Protocols & Hormone OptimizationThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro01:47 - Steroids and PEDs in Bodybuilding  02:59 - Podcast Setup and Audio Talk  03:41 - Science Without an Agenda  04:22 - GLP-1 and GLP-300008:19 - Insulin, Diets, and Brain Health  10:26 - Berberine and Supplement Bioavailability  13:04 - Beta-Alanine and Sodium Bicarbonate  14:59 - Citing Studies and Research Quality  17:32 - Natural Alternatives to Pharmaceuticals  19:34 - Esters and Compound Solubility  21:29 - Brian's Bodybuilding Journey  24:56 - Steroid Protocols and Half-Lives  30:34 - PCT and Fertility Strategies  38:44 - HCG and Male Contraception  41:53 - SARMs and Their Risks  46:08 - GHB as a Supplement  47:40 - GHB Risks and College Stories  50:32 - Prescription GHB and GABA Dangers  51:48 - Long-Term Effects of Sleep Meds 

Trensparent with Nyle Nayga
Olympian Steve Kuclo: Enhanced Bodybuilding & When You Should Stop

Trensparent with Nyle Nayga

Play Episode Listen Later Jun 8, 2025 122:27


6th at Olympia (2019), 3rd at Arnold, entrepreneur, husband, and father @stevekucloThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro  02:38 - Challenges of Monetizing Bodybuilding  04:09 - Transitioning to Health & Wellness  05:37 - Bodybuilding Prep & Off-Season Strategies  07:46 - Truth About Steroid Dosages  09:19 - Training as the Game Changer  11:15 - Female Trainers & Intensity  12:54 - Early Bodybuilding Journey & Mentorship  16:33 - Building Muscle Over Time  18:59 - Nutrition for Growth vs. Longevity  23:30 - Shifting to Health-Conscious Bodybuilding  26:20 - Maintaining Insulin Sensitivity  29:27 - Optimizing Testosterone Levels  32:20 - Reducing Inflammation with Supplements  37:39 - Glutathione & Detox Support  39:49 - Smarter Supplement Choices  41:03 - B Vitamins for Inflammation & Sleep  43:10 - Science-Based Training & Apps  45:56 - When to Retire from Bodybuilding  50:40 - Health Markers to Monitor  53:37 - Genetic Testing & Alzheimer's Prevention  56:38 - Brain Health & Mental Stimulation  58:20 - Journey into Bodybuilding & Firefighting  1:02:22 - Building a Fitness Business  1:08:56 - Managing Allostatic Load  1:11:16 - Stress & Anxiety in Competition  1:13:51 - Pushing Limits as a Firefighter  1:15:47 - Early DC Training Days  1:17:14 - Evolution of Training Methods  1:19:50 - Balancing Intensity & Smart Lifting  1:21:16 - High-Volume Heavy Training  1:23:27 - Science vs. Bodybuilding Methods  1:26:22 - Off-Season Testosterone Strategy  1:31:53 - Health-Focused Bodybuilding  1:32:56 - Favorite Bodybuilding Show  1:34:32 - Comeback & Boxing Plans  1:36:01 - Regenerative Medicine Tips  1:37:35 - Genetics & Strength Secrets  1:39:51 - Craziest Pre-Contest Cycle  1:41:32 - Project Super Heavyweight  1:43:57 - Top 5 Training Exercises 1:45:26 - Toughest Firefighting Moments  1:47:07 - TRT Plus Approach  1:50:28 - Low-Dose Transformation  1:52:57 - Dealing with Online Haters  1:54:01 - Hair Loss & Restoration  1:57:03 - Time Management Tips  1:59:01 - Life-Changing Final Message  2:02:11 - Thanks  

Group Practice Accelerator
Supply Spend Semaglutide? Systems for Proactively Protecting Your Cash Flow with Method's Alison Farber

Group Practice Accelerator

Play Episode Listen Later Jun 5, 2025 38:13


Join Jamie as she welcomes Method VP of Sales, Alison Farber, as they discuss scalable ways to tame the wild west of supply spend. Be prepared to take notes as Alison walks listeners through e-procurement, cost containment, inventory and budgeting best practices that directly impact the bottom line of your business. Get ready to hit auto-pilot and $AVE this month with Alison's proactive tactics and expert advice!

The Rounds Table
Episode 121 - Tirzepatide vs. Semaglutide for Obesity

The Rounds Table

Play Episode Listen Later Jun 5, 2025 7:53


Send us a textWelcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published head-to-head trial exploring the safety and efficacy of tirzepatide compared to semaglutide for obesity management. Here we go!Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (0:00 – 7:07).The Good Stuff:Trial Files, a free monthly newsletter on practice-changing trials, delivered straight to your inbox. (7:08 - 7:53)Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Sensible Medicine
This Fortnight in Medicine

Sensible Medicine

Play Episode Listen Later Jun 4, 2025 37:09


We are beginning a new series today. John and Adam will discuss a couple of articles we found interesting. Please let us know your thoughts. This week:Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated SteatohepatitisTiotropium Initiation and Dementia Risk in Chronic Obstructive Pulmonary Disease This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Primary Care Update
Episode 182: atrial appendage occlusion for AF, oral semaglutide, and epidural steroidsand

Primary Care Update

Play Episode Listen Later Jun 4, 2025 28:47


Join Mark, Henry, and Gary (we are Kate-less unfortunately this week) for discussion of epidural steroid injections for adults with radicular back pain, post a fib ablation management, and oral semaglutide for high-risk patients with Type 2 DM

The Well
Let's Talk About Our Weight

The Well

Play Episode Listen Later Jun 4, 2025 31:56 Transcription Available


Can you actually be healthy at any weight? What do leeches have to do with gynaecological issues? And what to do if you keep getting styes in your eye. In this episode, we have an important conversation about weight. Endocrinologist Dr Isobelle Smith talks about whether weight loss is more than just calories in and calories out, how to downsize fat not muscle and what your hormones have to do with your weight. We also discuss whether BMI is still a valid measure and how focusing on your health, rather than your weight may be the key. Also, is a “weight set point” actually a thing? Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can email well@mamamia.com.au, send it anonymously here, email here or leave us a voice note here. Ask The Doc: Ask us a question in The Waiting Room. THE END BITS Follow us on Instagram and Tiktok. All your health information is in the Well Hub. Support independent women’s media by becoming a Mamamia subscriber CREDITS Hosts: Claire Murphy and Dr Mariam Guest: Dr Isobelle Smith Senior Producers: Claire Murphy and Sasha Tannock Audio Producer: Scott Stronach Video Producer: Julian Rosario Mamamia studios are styled with furniture from Fenton and Fenton. Visit fentonandfenton.com.au Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.Support the show: https://www.mamamia.com.au/mplus/See omnystudio.com/listener for privacy information.

Plant Based Briefing
1071: Rising Malnutrition Risks Spark Push for Plant-Based Diets Among Ozempic Users by Charlotte Pointing at VegNews.com

Plant Based Briefing

Play Episode Listen Later Jun 2, 2025 7:31


Rising Malnutrition Risks Spark Push for Plant-Based Diets Among Ozempic Users Experts share why a diet rich in plant-based, nutrient-dense foods is key to staying healthy when using medications that curb your appetite. Listen to today's episode written by Charlotte Pointing at VegNews.com #vegan #plantbased #plantbasedbriefing #semaglutide #glp1 #ozempic #wegovy #malnutrition #scurvy #plantbasednutrition ========================== Original post: https://vegnews.com/ozempic-glp-1-malnutrition  Related Episodes: 994: [Part 1] Obesity: Is a GLP-1 Deficiency Its Cause, and How to Treat It Without Ozempic and Other Drugs https://plantbasedbriefing.libsyn.com/994-part-1-obesity-is-a-glp-1-deficiency-its-cause-and-how-to-treat-it-without-ozempic-and-other-drugs-by-dr-michael-greger-at-nutritionfactsorg  995: [Part 2] Obesity: Is a GLP-1 Deficiency Its Cause, and How to Treat It Without Ozempic and Other Drugs https://plantbasedbriefing.libsyn.com/995-part-2-obesity-is-a-glp-1-deficiency-its-cause-and-how-to-treat-it-without-ozempic-and-other-drugs-by-dr-michael-greger-at-nutritionfactsorg  984: How to Control the Side Effects (Including “Ozempic Face”) of GLP-1 Drugs https://plantbasedbriefing.libsyn.com/984-how-to-control-the-side-effects-including-ozempic-face-of-glp-1-drugs-by-dr-michael-greger-at-nutritionfactsorg  977: Why Weight Loss Plateaus On Diets https://plantbasedbriefing.libsyn.com/977-why-weight-loss-plateaus-on-diets-by-dr-michael-greger-at-nutritionfactsorg  965: Why All Ozempic, Wegovy Patients Should Consider a Plant-Based Diet https://plantbasedbriefing.libsyn.com/965-why-all-ozempic-wegovy-patients-should-consider-a-plant-based-diet-by-lindsay-morris-at-forksoverknivescom  741: The Ozempic Effect: Plant-Based Docs on the Pros and Cons of Semaglutide https://plantbasedbriefing.libsyn.com/741-the-ozempic-effect-plant-based-docs-on-the-pros-and-cons-of-semaglutide-by-courtney-davison-at-forksoverknivescom    Related Episodes: use search feature at https://www.plantbasedbriefing.com/episodes-search  Search for soy   ======================== Launched in 2000, VegNews is the largest vegan media brand in the world. They have a best-selling plant-based magazine, and they create amazing content from food and fashion to travel, celebrity interviews, beauty and health info, a meal planner, and vegan travel excursions. Their Guide section on their website is full of great information and they have an online shop where you can find cookbooks, foods, kitchen tools, vegan meal delivery services. They also have a website, VeganWeddings.com. Please visit www.VegNews.com for a wealth of resources.  ======================== FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866 Facebook: https://www.facebook.com/PlantBasedBriefing   LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/     

Tiny Matters
Ozempic: The science behind this blockbuster drug and its untapped potential

Tiny Matters

Play Episode Listen Later May 28, 2025 26:00


In December 2017, the FDA approved a new injectable drug to treat type 2 diabetes called semaglutide, which you likely know by its brand name: Ozempic. A few years later, during the pandemic, Wegovy, a drug with a higher dose of the same active ingredient, was approved specifically for chronic weight management. Soon after, people taking Ozempic started reporting a dramatic, even “life-changing” weight loss. Ozempic is now a bona fide blockbuster. So what's the science behind these “wonder drugs” that apparently 1 in 10 of us could end up using? They have the potential to have so many positive effects on our lives, from treating Alzheimer's disease and addiction to changing our relationship with consumption but, like with most things, they also come with risks.Send us your science facts, news, or other stories for a chance to be featured on an upcoming Tiny Show and Tell Us bonus episode. And, while you're at it, subscribe to our newsletter!Links to the Tiny Show and Tell stories are here and here. All Tiny Matters transcripts and references are available here.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Healthed Australia
Tirzepatide compared to semaglutide for treatment of obesity – Latest evidence

Healthed Australia

Play Episode Listen Later May 28, 2025 18:01


In this Healthed lecture, A/Prof Samantha Hocking provides an update on this latest study and what it means for prescribing clinicians who are using these agents as part of their management of patients with obesity.See omnystudio.com/listener for privacy information.

Trensparent with Nyle Nayga
Iain Valliere and I Settle On The Average Dosages

Trensparent with Nyle Nayga

Play Episode Listen Later May 26, 2025 185:50


Olympian, 6x IFBB Pro Champion, & best of all Chris Bumstead's brother in lawThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro  03:02 - Switching to Patrick & European Secrets  11:03 - Back-to-Back Competing  20:18 - Minimal Water Manipulation & Sweating on Stage  22:35 - Nick and Derick  39:57 - Iain on Rebounds  49:51 - Iain Almost Quitting Bodybuilding and Meeting Melissa  1:05:04 - TREN  1:12:51 - Iain's Relationship with Compounds Throughout His Career  1:16:49 - Different Training Methods & Iain's Opinion  1:34:58 - GLP-1s  1:48:51 - How People Look vs. Their Personalities  2:00:27 - Coaching Chris Bumstead  2:14:53 - Iain's Best Body Part  2:26:46 - Breakup Advice for Bodybuilders  2:27:56 - Bodybuilders' Fertility  2:31:57 - HCG for Fertility  2:34:21 - Growth Hormone  2:39:45 - Iain's Best Offseason  2:44:31 - Offseason Gear Discussion  2:52:13 - Most Bodybuilders Having Girls & Iain's Preference&

The Rounds Table
Episode 119 - Semaglutide for MASH

The Rounds Table

Play Episode Listen Later May 22, 2025 6:33


Send us a textWelcome back, Rounds Table Listeners! This week we have a solo episode with Dr. John Fralick, discussing a recently published trial of the GLP-1 receptor agonist semaglutide for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). Here we go!Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (0:00 – 6:33).The Good Stuff:Go Leafs go!Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

The Root Cause Medicine Podcast
The Power of Personalized Medicine: Exploring Compounding with Sara Hover, RPh

The Root Cause Medicine Podcast

Play Episode Listen Later May 20, 2025 45:44


In this episode of the Root Cause Medicine Podcast, Dr. Carrie Jones sits down with seasoned compounding pharmacist Sara Hover, RPh, to demystify the world of personalized medications. They dig into how compounding pharmacies offer tailored solutions for hormone therapy, acne, hair loss, weight loss, and more—and why this approach can be life-changing for patients who've hit dead ends with conventional medicine. Sarah shares eye-opening stories, from hormone creams and sublingual weight loss medications to pediatric popsicles and custom thyroid solutions, showing just how flexible and powerful compounding can be. What You'll Learn: - What compounding pharmacies actually do—and why it matters - Why the finished compounded meds aren't FDA-approved (and why that's okay) - How bioidentical hormone therapy transforms women's health - Solutions for allergies to common fillers like red dye or peanut oil - Fun and effective delivery forms: lozenges, topical creams, even popsicles - Hair loss, acne, eczema, and anti-aging compounding options - The surprising science behind sublingual GLP-1s for weight loss - How to find (or help your doctor become) a compound-friendly provider Sara Hover, RPh is a compounding pharmacist with 30 years of experience and a specialty in hormone replacement therapy. She serves as a lead educator at PCCA, where she trains pharmacists and providers on the latest in compounding innovations. Sarah is passionate about personalized, patient-centered care—and believes no one should be told they're "crazy" when a tailored medication might be the real solution. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Hacking Your Health
The secret to going from 320lbs to Six-Pack Abs

Hacking Your Health

Play Episode Listen Later May 20, 2025 58:37 Transcription Available


Ever wondered how people make dramatic body transformations that actually last? In this raw and honest episode, Dave Kennedy opens up about his five-year journey from 320 pounds to the best shape of his life at age 42."How do you do it?" Dave reveals it's not about quick fixes or miracle diets, but rather a "system of disciplines, a system of regiments, a system of consistency" built gradually over time. Both hosts break down the common misconceptions around fitness transformations, explaining why dramatic overnight changes rarely stick. Instead, they advocate for building small, sustainable habits that eventually become lifestyle changes.The conversation tackles the hierarchy of importance in fitness: why food management trumps exercise when starting out, how to separate the roles of calorie management, cardio, and resistance training, and the vital importance of patience. Dave shares candid insights about formerly weighing 320 pounds and how tracking calories fundamentally changed his relationship with food, while Ben offers practical frameworks for approaching fitness as a long-term journey rather than a quick sprint.They don't shy away from discussing controversial topics like GLP-1 agonists (Semaglutide, Tirzepatide), acknowledging their benefits while emphasizing they're not substitutes for building proper habits. Perhaps most powerfully, they explore how community support creates accountability and knowledge-sharing that dramatically increases success rates.Whether you're just starting your fitness journey or trying to break through a plateau, this episode delivers actionable wisdom from two people who've both lived the transformation process. Subscribe, share with someone who needs to hear this message, and join us in building sustainable systems that change lives.Support the showCheck out Overclock and Protein Protocol hereWant to know more about coaching? Book a call with Ben here Where to find usWe Hack Health: TwitterWe Hack Health: InstagramWe Hack Health: Discord

Dr. Pepper....Really?
Can the Microbiome Replace Ozempic? Two Experts Weigh In on This Radical Theory

Dr. Pepper....Really?

Play Episode Listen Later May 20, 2025 26:00 Transcription Available


Can the Microbiome Replace Ozempic? Two Experts Weigh In on a Radical Theorywith Dr. Gary Pepper & Mary Gocke, RDN, CDN, CHTAre we overlooking the natural power of the gut microbiome in managing weight and metabolism?In this eye-opening conversation, Dr. Gary Pepper — a seasoned endocrinologist — teams up with renowned nutritionist and functional medicine expert Mary Gocke to explore whether the body's own microbiome might one day rival pharmaceutical GLP-1 drugs like Ozempic and Wegovy. From nutritional strategies to protect muscle and bone during weight loss, to the role of akkermansia and polyphenols in boosting natural GLP-1 production, this discussion offers a radically fresh perspective on sustainable metabolic health.Topics covered in this episode include:What GLP-1 medications like Ozempic actually do — and what they don'tWhy weight loss can lead to malnutrition, muscle loss, and even bone density declineHow the gut microbiome — especially Akkermansia muciniphila — may support natural GLP-1 productionThe critical importance of dietary fiber, polyphenols, and prebiotics in metabolic healthHow protein needs shift during rapid weight loss and how to calculate your target intakeEarly evidence for and against the long-term use of GLP-1 drugsThe promising but controversial concept of microdosing and tapering off GLP-1sSimple strategies to protect your body from the side effects of medical weight lossWhy resistant starches (like cooled potatoes and rice) might actually help your microbiomeThe silent risk of osteoporosis from poorly managed weight lossWhether you're currently on a GLP-1 medication, considering one, or exploring natural alternatives, this candid and science-based conversation will equip you with insights not found in mainstream media.

Trensparent with Nyle Nayga
BiohackingU: How Steroids Damage Your Brain & Emotions and How To Prevent & Improve it

Trensparent with Nyle Nayga

Play Episode Listen Later May 18, 2025 120:09


Brandon Eisenlauer, aka  @BiohackingUThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 – Intro08:28 – Neuro-toxicity of popular PEDs (19-nors, Tren, etc.)11:42 – Brain-basics: Neuro-steroid support16:18 – Dopaminergic Life & Consequences21:32 – Real Risk of Bodybuilding, Rest & The Right Way27:04 – Managing Mental Stress: Meditation & Mindful Break38:30 – Gen Z, Motivation Gaps & “Just Go Live Life”41:17 – Independence & Growth42:46 – Psychedelics & Neuroplasticity43:45 – Hustle Culture vs Balance46:40 – Cultural & Political Extremes48:40 – Finding Balance in Bodybuilding52:19 – Conscientious Growth53:50 – Brain Protection Strategies57:01 – Serotonin & SSRI Benefits58:33 – Cholinergic, Sleep Support & GABA System1:03:30 – SSRIs Stigma & Pharma Bias1:12:45 – Best Cycle Principles1:19:38 – Pharmacology Caveats & Nuance1:25:25 – Finding Reasons Is Hard & Adaptation1:27:52 – Mitochondrial & Estrogenic Peptides1:36:14 – Stimulant Cycling Strategy & Risks1:47:10 – Injectable Amino Blends1:52:17 – Peptide Safety & Cancer1:57:36 – Skin Health & Peptides1:59:46 – The Final Question

The Wright Report
16 MAY 2025: Headline Brief: Democrats Applaud Trump // Chinese Withhold Rare Earths // Germany Submits to Trump // Mexican Migrant Tax // Great Medical News

The Wright Report

Play Episode Listen Later May 16, 2025 26:09


Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, for The Wright Report: Friday Headline Brief—heavy on news, light on analysis—to kick off your weekend with the stories shaping America and the world. Trump's Middle East Tour Draws Unlikely Praise – Top Obama and Biden officials, including Ben Rhodes and Rob Malley, applaud Trump's bold diplomacy in Syria, Gaza, and with Arab partners. Even Democratic Rep. Jim Himes admits Trump “played the Middle East pretty darn well.” Gaza “Freedom Zone” and a Rift with Apple – Trump floats the idea of the U.S. taking over Gaza. He also blasts Apple CEO Tim Cook for moving production to India, accusing the company of betraying American workers. China Floods U.S. with Goods While Hoarding Minerals – Despite the tariff truce, China withholds critical rare earth exports while ramping up production of consumer goods—especially for Halloween and Christmas. Xi Jinping mocks America's dependency on cheap imports and takes shots at Trump in front of Latin diplomats. Germany Bows to Trump's NATO Demands – In a surprise move, Germany pledges to meet Trump's 5% defense spending target, shocking European allies and boosting defense stocks. GOP Pushes Remittance Tax, Mexico Furious – A new Republican proposal would tax wire transfers to fund a $5T tax package. Mexico's president and senate condemn the idea as discriminatory and fear it will push money transfers underground. Supreme Court Grills Trump Admin on Citizenship Case – Justices express skepticism over Trump's executive order to end birthright citizenship and the broader issue of universal injunctions. Medical Breakthroughs: Fentanyl Deaths Decline, GLP-1 Drugs Help Alcoholics and Liver Disease – CDC data shows overdose deaths are down. Semaglutide shows promise in treating alcoholism, liver disease, and may reduce Alzheimer's risk. Prostate Cancer Treatments Improve, Exercise Lowers Risk and Aids Recovery – New research supports shorter, safer radiation schedules, while exercise helps reduce complications, dementia risk, and cognitive decline. "And you shall know the truth, and the truth shall make you free." – John 8:32

The Wellness Mama Podcast
Setting Women Free From the Chains of Dieting With Shay Pascale

The Wellness Mama Podcast

Play Episode Listen Later May 14, 2025 55:59


Episode Highlights With ShayThe common problems with most conventional diet models What's going on when we feel like we're doing everything right but nothing is changing We start losing muscle in our 30s if we aren't working to increase it. How this affects metabolism and what to do about itThe problems with calories in and calories out and why there's more to the storyMindset shifts away from restriction to fueling the bodyWhat a reverse diet is and how it can be so helpful!Why protein is so important and what the data actually saysHow to build muscle as we age and the importance of strength training When those pieces don't work: addressing deeper variables like gut health, hormones, liver health, parasites, etc.Her take on semaglutide and alternative optionsResources MentionedThe Body Bulletin on InstagramThe Clean Eating Challenge

Freely Filtered, a NephJC Podcast
FF 80 KDIGO ADPKD Guidelines

Freely Filtered, a NephJC Podcast

Play Episode Listen Later May 13, 2025 78:01


The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

NeuroEdge with Hunter Williams
Retatrutide vs Alcohol: The Secret Brain Hack to Beat Addiction

NeuroEdge with Hunter Williams

Play Episode Listen Later May 13, 2025 28:46


Study Link: http://biorxiv.org/content/10.1101/2025.04.17.649402v1.full.pdfGet My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Docs Who Lift
Zepbound versus Wegovy

Docs Who Lift

Play Episode Listen Later May 12, 2025 20:57


Tirzepatide is more effective for weight loss than semaglutide.Cost-effectiveness is crucial in prescribing weight loss medications.Patients with severe obesity should receive more expensive medications for better outcomes.Both medications show significant benefits for obesity-related conditions.Long-term studies indicate sustained weight loss with both drugs.Gender differences affect weight loss outcomes with these medications.Safety profiles show tirzepatide may be better tolerated than semaglutide.The need for affordable drug pricing is emphasized.Clinical benefits extend beyond weight loss to include metabolic health.Future studies are needed to confirm cardiovascular benefits of tirzepatide.Click here to see the studyClick here to join Dr. Spencer's new online clinic

Trensparent with Nyle Nayga
Primo/Mast, Doses, GLP-1, & Anxiety - Eric Janicki & Markus Hunter

Trensparent with Nyle Nayga

Play Episode Listen Later May 12, 2025 124:55


The first Temu chat.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com

CBS This Morning - News on the Go
Nicole Scherzinger On How "Sunset Blvd." Changed Her Life | New Study Compares Effectiveness of Weight Loss Drugs

CBS This Morning - News on the Go

Play Episode Listen Later May 12, 2025 38:57


CBS News MoneyWatch correspondent Kelly O'Grady breaks down what to know about the potential financial impact to American consumers after the U.S. and China agreed to temporarily ease tariffs. Music superstar Taylor Swift has been subpoenaed in the ongoing legal dispute between Blake Lively and Justin Baldoni over allegations surrounding the making of their 2024 film "It Ends with Us."  A new study from the New England Journal of Medicine compares two weight loss drugs, Tirzepatide and Semaglutide. CBS News medical contributor Dr. Celine Gounder breaks down the findings. Nicole Scherzinger is making her Broadway debut in the stripped down, modern revival of "Sunset Blvd." She talks with "CBS Mornings" about the show, taking on the role and her first Tony nomination. In an exclusive "Begnaud's America" interview, CBS News contributor David Begnaud speaks with Gus Waltz, the son of Minnesota Gov. Tim Walz, who stole the spotlight during the 2024 Democratic National Convention. He's opening up about that moment and a learning disorder that is often misunderstood. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Comida sem Filtro
Comida sem filtro #200 - Mounjaro

Comida sem Filtro

Play Episode Listen Later May 12, 2025 25:52


Os medicamentos injetáveis para emagrecimento, conhecidos como “canetas emagrecedoras”, incluindo Ozempic, Wegovy, Saxenda, Mounjaro e similares vinham sendo vendidos livremente no Brasil, sem a necessidade de prescrição médica. Mas isso vai mudar.A Agência Nacional de Vigilância Sanitária (Anvisa) aprovou uma nova regra para a venda desses medicamentos, que só poderá ser feita mediante apresentação de receita médica em duas vias, sendo que uma delas ficará retida na farmácia - procedimento semelhante ao já adotado para antibióticos.Neste episódio, conversamos sobre as indicações desses medicamentos, seus efeitos colaterais e a importância do acompanhamento médico para o uso correto.Links relacionados:Tirzepatide as Compared with Semaglutide for the Treatment of ObesityComida Sem Filtro #88 – Injetáveis Para EmagrecerComida Sem Filtro #146 – Ozempic: Como Evitar O Reganho De Peso?Comida Sem Filtro #125 – Efeito Ozempic Na Indústria De AlimentosEstamos no Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Dr. Souto⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sari Fontana⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Para ser avisado sobre cada novo episódio e receber os links das matérias mencionadas e as referências bibliográficas por e-mail, cadastre-se gratuitamente em ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drsouto.com.br/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Adquira seu livro - UMA DIETA ALÉM DA MODA: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (também na versão Kindle)"Dance of the Sugar Plum Fairy"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://creativecommons.org/licenses/by/3.0/⁠

Cut The Crap With Beth And Matt
194 - Be Strong, Not Skinny

Cut The Crap With Beth And Matt

Play Episode Listen Later May 9, 2025 64:09


Have you ever said "Nothing tastes as good as skinny feels"? If you were around in the 80's and 90's, you likely either said this or have heard it before, thanks to some notorious fad diet programs out there. This week we are discussing the "Skinny Tok" trend that is coming back full circle and bringing with it all of the diet culture sayings and trends that we are working so hard to leave behind. There is a harmful narrative and focus in social media about being skinny again and its hard to ignore the correlation between this type of messaging and the popularity of weight loss drugs.We also rant and rave about peptide supplements and MLM companies trying to capitalize on GLP-1 drugs like Wegovy, Semaglutide, Terzepetide, and more - further proving that diet culture and the supplement industry won't rest until they squeeze every last penny out of you.Buckle up and tune in because we've got some things to say!Subscribe, stack, and save with Cured Nutrition! Never run out of your supply of Serenity or Flow gummies by subscribing and receive 20% off! In addition to that, you can stack your favorite bundle (we love the Harmony bundle!) to receive an additional 10% off. ⁠⁠Click here⁠⁠ for huge savings and don't forget to add our code 'CTC' for additional savings! Thank you Cured Nutrition for sponsoring this episode!Right now you can become an annual member of our Patreon and receive 30% off! Join now for monthly workouts, challenges, recipes, and to become part of the Cut The Crap Community! https://www.patreon.com/cutthecrappodcast⁠⁠⁠Visit our website to learn more about us, contact us, inquire about collaborating with us and more: ⁠⁠⁠https://www.cutthecrappod.com/⁠⁠⁠Follow us on Instagram: @cutthecrapwithbethandmattLike this episode? Why not share it with a friend!Send us a DM on Instagram to let us know what you think of this one, and with episode ideas! If we use your comment or suggestion, we'll give you a shoutout on the podcast!

Trensparent with Nyle Nayga
Daniel Fabode: Classic Olympian Openly Discusses His Cycles & PED Protocols

Trensparent with Nyle Nayga

Play Episode Listen Later May 5, 2025 159:53


3rd Place At Detroit Pro next to Wesley Vissers and Matt Greggo, Olympian Classic IFBB Pro Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com

Docs Who Lift
Semaglutide for metabolic dysfunction associated steatotic liver disease (MASH).

Docs Who Lift

Play Episode Listen Later May 2, 2025 22:20


TakeawaysMASH is a significant obesity-related complication.Semaglutide shows promise in treating MASH.Weight loss is crucial for improving liver health.Bariatric surgery remains the most effective treatment.The Essence trial indicates a 63% resolution of NASH.New medications are being developed for obesity treatment.Early intervention is key to preventing severe liver damage.Accessibility of medications is a major concern.Comparative studies are essential for evaluating new treatments.Future treatments may include innovative delivery methods.Chapters00:00 Introduction to MASH and Semaglutide Study04:29 Understanding Metabolic Dysfunction and Its Implications08:02 Essence Trial: Semaglutide's Impact on MASH12:58 Comparative Analysis of New Treatments for MASH17:30 The Future of Obesity Treatment and Drug AccessibilityJoin Vineyard - Dr. Spencer's online clinicSee the study

CBS Evening News
CBS Evening News, 04/30/25

CBS Evening News

Play Episode Listen Later Apr 30, 2025 26:26


U.S. economy shrinks. Semaglutide, the main ingredient in diabetes and weight loss drugs Wegovy and Ozempic, may also reverse the signs of liver disease by reducing inflammation and scarring. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices