Podcasts about semaglutide

In response to the article I wrote in The Times about whether I was daft for not using skinny jabs to lose weight, I thought revisiting my conversation with Johann Hari about his book Magic Pill, which extensively researched the benefits, limitations and risks of GLP-1 Agonist drugs such as Ozempic, Semaglutide, Wegovy and Mounjaro.Johann is thorough and meticulous in his research and this interview, originally broadcast in 2024, was before weight loss drugs became as mainstream and as widely prescribed as they are today.One of the experts Johann interviewed during his years of research, stated that the cultural impact of GLP-1s was as significant as the smart phone. At the time, it seemed like a very bold statement, but in the year since we spoke, I think it's hard to argue that they haven't completely changed the way we talk about weight, weight loss, diets, food and more...I'd love to hear your thoughts on this episode. Email me at office@emmaguns.com or Subscribe to my Substack and join the chat there. Hosted on Acast. See acast.com/privacy for more information.

In first-ever study, keto diet scores vs. Parkinson's; Walk away from dementia; Loneliness can kill, but negative social ties can hasten biological aging; Researchers isolate potent memory compound from sage, rosemary; Sketchy knockoff weight loss drugs are flooding the marketplace; The popular vitamin you shouldn't take for sarcoidosis; When osteoporosis is so severe that even minor trauma causes rib fractures.

IFBB Pro Open Bodybuilder, 2023 Chicago Pro Champ, & Olympian, known for his wild proportions & training style.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro02:05 - Pod Setup03:41 - Relationships & Personal Stories05:04 - Dealing with Loss13:20 - Grief and Maintaining Routine16:27 - Navigating Life Transitions21:40 - Contest Prep Updates27:08 - Gut Health Protocol Impact30:59 - Lifelong Gut Issues42:36 - Justin being comparatively small44:35 - Cycles, Training Styles & Genetics50:16 - You are not gonna feel great all the time!54:44 - Eric Janicki & Training to Failure01:03:44 - Journey to Bodybuilding01:08:52 - Longevity in Bodybuilding01:14:25 - Growth Hormone Experiences01:18:34 - Training Style Evolution01:20:09 - Coach Behind Justine & Motivation01:27:03 - Balancing Bodybuilding, Business and Relationships01:32:02 - Being Raised Perfectly01:40:33 - Moderate Dosage Benefits & Being Health Conscious01:47:49 - Consistency in Training01:55:21 - Acne Struggles & Solutions02:04:58 - Obsession vs. Balance in Prep02:09:06 - Peak Week Nutrition02:14:04 - Frenchie vs. Pug Debate02:19:33 - Cannabis Business Role02:24:33 - Delegating in Business02:27:00 - Getting competition lean on burgers02:32:23 - Training Frequency Benefits02:39:55 - Exercise-Specific Training02:43:59 - Back Density Movements02:46:34 - Olympia Stress Disaster02:57:10 - Do What You Love

Titrate, Train, Triumph

Send us a textWelcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2024:Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (FINEARTS-HF) (0:00 – 4:09)Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA) (4:10 – 9:28)Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW) (9:29 – 14:23)Tirzepatide for Metabolic-Dysfunction Associated Steatohepatitis with Liver Fibrosis (SYNERGY-NASH) (14:24 – 20:28)Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (BALANCE) (20:29 – 23:59)And for the Good Stuff:Toronto Star Santa Claus Fund, Calgary Food Bank, Epilepsy Canada (24:00 - 25:23)Calling keen trainees!Trainees, med students, residents: The Rounds Table and Trial Files (https://trialfiles.substack.com/) are looking for keen individuals to support our efforts.Reach out to fralickmpf@gmail.com if you are interested in getting involved. Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

In this episode, Dr. Melody joins the show to discuss the critical role hormones play in weight loss, particularly for women aged 35 to 65. The conversation delves into the misconceptions surrounding hormone replacement therapy and the benefits of using hormones appropriately to support health and well-being.

Strongest legal performance enhancers, methods, and more to improve your recovery, endurance, overthinking, mental clarity, cognition, fatigue threshold, longevity, and so much more to get the edge on your competition.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 – Intro to Dr. Scott Sherr00:02:27 – Podcast Warm Up - Dr. Scott's teachings and bodybuilding00:05:40 – Brain Health in Bodybuilding00:08:12 – Overtraining & Parasympathetic Recovery Challenges00:10:32 – Post-Workout Parasympathetic Strategies - GABA00:14:02 – CO2 Tolerance Training for Performance00:16:42 – Breathwork Techniques for CO2 Training00:20:03 – Caffeine & Nicotine in Workouts00:23:12 – Individual Responses to Supplements00:27:13 – Deep Dive into GABA & Supplementation Risks00:37:40 – GHB & Phenibut for Deep Sleep00:42:44 – GABA supplementation/ Glutamine & Gut Health00:46:15 – Caffeine & Nicotine for Brain Health00:52:56 – Nootropics: Health vs. Performance01:04:11 – Blood Sugar Control & Key Supplements01:12:49 – Methylene Blue for Performance01:20:29 – Hydration + Methylene Blue Travel Stack01:22:03 – Methylene Blue Dosing, Safety & Delivery01:28:41 – Methylene Blue Success Stories01:33:50 – Sleep Optimization: Sauna & Hyperbaric Therapy01:39:03 – Hyperbaric Therapy Explained01:50:56 – Mitochondrial Health & Sexual Performance01:53:24 – Where to Find Dr. Scott

Professor Clare Collins delves into the world of nutrition and obesity medications with Sally Badorrek, Accredited Practising Dietitian from the University of Sydney. With 25 years of clinical experience in nutrition management of chronic conditions like obesity and diabetes, Sally shares insights on the latest medications, their side effects, and the importance of a holistic approach to weight management. We discuss the science behind new obesity medications like Semaglutide and Tirzepatide, how they work, common side effects and strategies to manage them, plus the critical role dietitians play in supporting patients on these medications. Together they unpack some myths and misconceptions around obesity treatments and discuss why a team-based approach is key to long-term health gain.Listen now to gain a deeper understanding of how these medications can aid in weight management and improve overall health. Whether you're a health professional, someone navigating weight management, or simply curious about the future of obesity care, this episode offers practical insights and compassionate perspectives.No Money No Time: Food and Mood Diary for tracking dietary habitsNo Money No Time: To access the FREE Healthy Eating Quiz: Click on the top right hand 'green button' called 'How healthy is my diet'No Money No Time closed Facebook group (be sure to take the Healthy Eating Quiz first)Find an Accredited Practising Dietitian hereDo you want a more Personalised Food, Nutrient Assessment Report? Our Australian Eating Survey includes an assessment of your nutrient (vitamin and mineral) intake. Use code 'DietCheck' at the checkout for 50% off! Purchase hereAre you in a position to make donation to support our No Money No Time website? Donate here#ObesityTreatment #DietitianAdvice #WeightManagement #Ozempic #Tirzepatide #Wegovy #ObesityMedication #Sideeffects Hosted on Acast. See acast.com/privacy for more information.

How the STEP-UP trial came to life,  and what made the 7.2mg dose possibleWhat the data actually says about weight loss and side effects at higher dosesWhy trial design, pharmacokinetics, and estimands matter more than you thinkWhat's coming next in obesity meds: duals, triples, and even antagonistsThe real talk on intermittent fasting, access issues, and preaching vs. scienceSign up for Dr. Spencer''s Clinic

GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are reshaping how we treat obesity — but there's so much confusion and stigma. That's why we sat down with leading obesity specialist Dr. Spencer Nadolsky for an honest, empowering conversation.We break down how GLP-1s actually work, why food noise is real, and what people aren't being told about compounded semaglutide, weight regain after bariatric surgery, and long-term success.If you've felt frustrated, misunderstood, or stuck — this episode is for you. Whether you're post-op, on medication, or considering your options, this episode brings science, support, and real talk together.

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro01:45 - Greg Doucett/ Kyle's Backup Team06:29 - Connecting Through Social Media09:43 - Inspiring Others with Disabilities11:29 - Overcoming Stereotypes with Bodybuilding15:45 - Feeling Left Out27:21 - Kyle's Diagnosis Story32:23 - Journey with Down Syndrome39:12 - Hormone Therapy Discussion48:41 - Testosterone Therapy Progress55:30 - Venice Beach Victory1:00:06 - Training Mindset & Failure1:04:05 - Manifesting Success1:07:15 - Men's Mental Health1:14:11 - Dealing with Depression1:20:11 - Finding Purpose in Tough Times1:23:20 - Kyle's Superhero Mindset1:27:32 - Kyle's Journey So Far1:39:17 - No Challenge is a Challenge for Kyle1:47:00 - Feeling Isolated and Finding Community1:50:19 - Nick Walker's Inspiration1:53:15 - Dealing with Anxiety2:03:15 - Connecting Through Opening Up2:11:20 - Final Message to the World

New Study Alert!

Welcome back to Ozempic Weightloss Unlocked, where we illuminate the latest about Ozempic's role in weight loss, health, and lifestyle transformation.Ozempic is in the spotlight as more people turn to it for help with weight loss, whether or not they have diabetes. GoodRx reports that Ozempic works by mimicking a hormone in your body that helps regulate blood sugar and suppress appetite, leading to fewer calories consumed. It also slows down how quickly food leaves your stomach and reduces sugar production in the liver. These combined effects can result in gradual, sustained weight loss.Clinical trials published by GoodRx show that people on a 1 milligram weekly dose of Ozempic lost an average of 13 pounds over about nine months. Even at the lower, 0.5 milligram dose, people with Type 2 diabetes lost about 8 pounds over seven months. While some use Ozempic for Type 2 diabetes, doctors may prescribe it off-label for weight loss in people with prediabetes to lower their risk of developing diabetes.However, Ozempic is not for everyone. Wegovy, which contains the same active ingredient as Ozempic, is actually approved by the Food and Drug Administration for weight loss in adults and children over 12 who are obese or overweight with at least one weight-related condition, such as high blood pressure.One of the biggest questions is why some people have better weight loss results than others using Ozempic. Medical News Today highlights new research showing that several factors influence outcomes. Longer time on the medication, higher starting body fat, and even blood sugar levels all appear to play a role in weight loss success, especially for men. For women, lower skeletal muscle mass was linked to greater weight loss. Results can be variable, and doctors caution that more long-term studies are needed to determine how best to maintain the benefits after stopping the medication.Not all effects of Ozempic are positive, and side effects are an important consideration. According to GoodRx, many people experience nausea, vomiting, and stomach pain, especially when first starting Ozempic or increasing their dose. Typically, these symptoms get better over time, but careful oversight and gradual dose increases help minimize discomfort.Another critical issue is how Ozempic affects body composition. Healthline reports on a new study showing that weight lost with Ozempic is not just fat—muscle mass can decrease as well. This is especially a concern for older adults and women. To help prevent muscle loss, researchers recommend upping your protein intake and engaging in regular strength training while on the medication. Registered dietitians suggest aiming for at least one point two to one point five grams of protein per kilogram of body weight each day, but always consult your healthcare team before making big diet changes.Another recent headline comes from Medical Xpress, which reports early indications that Ozempic could have benefits beyond weight loss, such as reducing the risk of stroke and complications related to certain brain injuries. These findings are still developing, but add to the growing discussion about the wide-ranging impacts of these new medications.While many achieve meaningful and sometimes life-changing results on Ozempic, experts stress the importance of close medical supervision. There is concern about people receiving these medications from providers outside of their usual healthcare teams, which can result in less comprehensive follow-up and care.To all our listeners: if you are considering Ozempic for weight loss, talk openly with your healthcare provider. Personal factors like muscle mass, body composition, existing conditions, and your ability to stick with healthy eating and exercise habits all influence your results and reduce risks.Thank you for tuning in to Ozempic Weightloss Unlocked. If you found today's insights helpful, be sure to subscribe so you never miss an update. This has been a quiet please production, for more check out quiet please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.ai

 In this episode of Good Day Health, Doug Stephan welcomes back Elizabeth Miller to talk about one of the most trusted natural weight loss supplements on the market — Calotren. Unlike trendy quick-fix programs or stimulant-based diet pills, Calotren supports sustainable weight loss and muscle health while you sleep. Taken before bed, it works with your body's natural healing cycle to:Improve sleep qualityReduce joint painSupport lean muscle retentionBoost metabolism and energyGently tone and tighten skinWith an 86% success rate in the first 90 days, users see better sleep by month 1, and steady inch and weight loss by month 2 and beyond — all without the rebound weight gain so common with other methods. Doug and Elizabeth also discuss the rise of prescription weight-loss shots and how Calotren is safe to use alongside them — in fact, it may be essential for helping your body retain lean muscle and avoid energy crashes or sagging skin. Plus: To celebrate their website relaunch at TopLoss.com, shoppers get free gifts with every order, and free shipping when you use promo code DOUG at checkout. Visit TopLoss.com, click on “Shop Radio Sale,” and start your Calotren journey today. Website: GoodDayHealthrShow.com Social Media: @GoodDayNetworks

On this episode of Good Day Health, host Doug Stephan and Dr. Ken Kronhaus of Lake Cardiology (352-735-1400) dive into this week's top health stories and answer listener questions with expert insights. First up: AI in medicine. Dr. Ken shares how he prefers to think of artificial intelligence as “Assisted Intelligence,” explaining how new technologies are enhancing diagnostics and patient care. One example? Advanced AI models can now analyze heart MRIs and medical records to detect subtle scar patterns that predict sudden cardiac death — a game-changer in preventive cardiology. Speaking of prevention, Dr. Ken emphasizes a growing “fourth pillar” in the fight against heart disease: vaccinations for common infections, joining the ranks of diet, exercise, and medication. Then, Doug shares a wild personal story: after days of ear pain and a misdiagnosis of infection, the true culprit was revealed — a ladybug stuck in his ear. This leads into a broader discussion on ear health and new research showing that wearing hearing aids may actually improve your social life. Also on the brain: New research finds that the human hippocampus — the brain's memory center — continues generating new neurons even in old age, offering new hope for cognitive longevity. Listener questions include:Is Semaglutide (Ozempic, Wegovy) offering more than weight loss benefits, such as protecting limbs in patients with Type 2 diabetes?What's up with the new COVID-19 variant XFG (“Stratus”) and its unusual symptom — a raspy voice?Join Doug and Dr. Ken for a fast-paced, informative hour packed with useful health tips, surprising discoveries, and practical advice for everyday wellness.Webstie: GoodDayHealthShow.comSocial Media: @GoodDayNetworks

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro  00:02:40 Personal Life Updates  00:04:51 Pregnancy and Lifestyle Changes  00:10:57 Early Steroid Use and Coaching  00:18:43 Sleep Schedules and Productivity  00:26:45 Bodybuilding Industry Evolution  00:27:52 Modern Bodybuilding Aesthetics  00:37:31 GLP-1 Agonists and Nutrition  00:41:37 Classic Physique and Weight Caps  00:46:51 Coaching and Knowledge Evolution  00:53:07 Family Genetics and Hard Work  00:56:55 Diminishing Returns With Protein  01:08:23 Growth Hormone Dosing Insights  01:16:41 Insulin and GH Combinations  01:22:54 Elite Coaching and Drug Testing  01:27:17 Insulin Resistance Myths  01:32:30 Social Media Arguments01:34:38 Trenbolone and Kidney Concerns  01:39:30 Smart Drug Choices in Bodybuilding  01:49:55 Living In Thailand01:56:35 HGH Timing 02:06:30 Tirzepatide vs. Retatrutide  02:12:00 Prescriptions and Traveling02:16:58 Reversing LVH Growth  02:22:42 Estradiol Levels on Cycle  02:27:04 Anabolic Synonymous Shutdown02:30:45 Classic Physique Drug Use 02:33:40 Life Updates and Fatherhood

In this episode, I sit down with Dr. Christle Guevarra—physician, educator, athlete, and all-around powerhouse—for a real, raw conversation about health, hormones, weight loss medications, and what it actually looks like to live inside a female body with high-level demands. Christle shares her personal and professional journey from academic burnout and disordered habits to becoming a leader in fitness-forward medicine.   We talk about everything from body image to semaglutide, muscle loss fears, perimenopause, and the psychological toll of chronic dieting. If you've ever struggled with your weight, your hunger cues, or simply wondered what's really going on behind the scenes of the latest health trends, this episode is for you.   Connect with Dr. Christle Guevarra: Instagram: @dr.christle YouTube: @rpstrength   Join the Practice Brave Fitness Program: briannabattles.com/practicebrave   If you're a pregnant or postpartum athlete looking for resources, I can help:   The Pregnancy Cheat Sheet Free E-Book: https://go.briannabattles.com/adjust-cheatsheet   The 8-Week Postpartum Athlete Training Program: https://go.briannabattles.com/8-week-postpartum-athlete-training-program     MORE ABOUT THE SHOW: The Practice Brave podcast brings you the relatable, trustworthy and transparent health & fitness information you're looking for when it comes to coaching, being coached and transitioning through the variables of motherhood and womanhood. You will learn from athletes and experts in the women's health and coaching/performance realm as they share their knowledge and experience on all things Pregnancy & Postpartum Athleticism. Whether you're a newly pregnant athlete or postpartum athlete, knowing how to adjust your workouts, mental approach and coaching can be confusing. Each week we'll be tackling questions around adjusting your workouts and mindset, diastasis recti, pelvic health, mental health, identity, and beyond. Through compelling interviews and solo shows, Brianna speaks directly to where you're at because she's been there too! Tune in every other week and share the show with your athlete friends!

Season 5 Episode 17 is live and in this episode continues to follow our new structure (for the most part) including the following segments:Bodybuilding Banger: This segment features a spotlight/sharing of a song perfect for fueling an intense workout. We explore the song's meaning, lyrics, instrumentals, breakdowns, vocals, etc. This week's Bodybuilding Banger is "All That I Remember" by The Amity Affliction. Coaches Corner: This segment features health and wellness information/tips to help you meet your goals. This week, we explore the GLP-1 agonist semaglutide. We discuss what they are, how they work, why they are controversial, and considerations for maintaining muscle mass. Song of the Week: We select a new metalcore song each week to highlight/share with you all. This week's song of the week is "Collide" by Kingdom of Giants.Training Tip: We discuss a training tip that may assist in taking your fitness goals to a new level. This week we discuss pyramid sets. Resources: https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonistshttps://medicine.iu.edu/blogs/bioethics/on-the-increase-in-use-of-glp-1s#:~:text=The%20increase%20in%20use%20of%20these%20drugs%2C%20though%2C%20can,taking%20one%20of%20these%20drugs.https://www.brgeneral.org/news-blog/2024/june/does-ozempic-make-you-lose-more-muscle-https://agelesscenter.net/blog/how-to-safely-wean-off-ozempic-for-weight-loss/https://www.uchicagomedicine.org/forefront/research-and-discoveries-articles/research-on-glp-1-drugsFollow us on Instagram @mc_muscle!Follow us on Instagram @mc_muscle!

I am honored to reconnect with Dr. Tracy Gapin today. He is a board-certified urologist and men's health expert.  The current state of metabolic health in the United States and most Westernized countries has sparked a great interest in a GLP1 agonist, AKA Semaglutide Ozempic. I wanted to speak with a clinician who actively uses this medication. Dr. Gapin and I discuss what this drug class represents. (These are synthetic peptides.) We speak about Semaglutide, Ozempic, Wegovy, and oral Rybelsus. We get into current research, side effects, who should not take these medications, the mechanisms of action specific to the pancreas and beta cells, reductions, gastric emptying, and the upregulation of satiety. We discuss changes in the brain regarding leptin and how these drugs work. We also talk about weight loss resistance, and I answer questions from listeners.  From my perspective, it all comes back to basics. I believe that if we are to prescribe these medications, we must help our patients understand how lifestyle impacts weight-loss resistance and metabolic health. I loved that Dr. Tracy spent some time talking about the specific ways he works with his patients, even before prescribing medications. He also explains how important he feels this drug has been for his patients. I approached today's conversation with an open mind, and I hope you will do the same. IN THIS EPISODE YOU WILL LEARN: GLP1 agonists, and how they help Dr. Tracy motivate his patients to lose weight What are GLP1 agonists, and how do they work? Physical benefits of GLP1 agonists Who is Semaglutide not appropriate for? Common side-effects of GLP1 agonists How those who fail to implement lifestyle changes when they stop using Semaglutide may regain all the weight they lost Hydration while using Semaglutide Protein intake when taking Semaglutide How to follow the metrics that matter Factors that could hinder successful weight loss What Dr. Tracy does to ensure his patients do not regain the weight they lost after they stop using Semaglutide Listener questions: Why is a diabetic drug being used for non-diabetics? Does this drug target muscle versus fat in terms of weight loss? For how long do most patients take it? Are there unique characteristics in perimenopausal and menopausal women that must be accounted for differently? Bio: Dr. Tracy Gapin is a board-certified urologist and a world-renowned expert in men's health and performance, as well as the founder of the Gapin Institute, the global leader in High-Performance Health.  He has over 20 years of experience focused on men's health optimization, human performance, and longevity, providing executives & entrepreneurs a personalized path to fulfill their highest potential. He's been featured in Entrepreneur, Dave Asprey's Biohacking Conference, and as a TEDx speaker. Connect with Cynthia Thurlow Follow on⁠ Twitter⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia's⁠ website⁠ Connect with Tracy Gapin On his⁠ website⁠ ⁠Gapin Institute⁠

A slew of ultra-powerful weight loss drugs are in the pipeline—ironic that Westerners need them so much? RFK Jr. wants every American to wear a fitness tracker; New study upends belief that inflammation is inevitable with aging; Rating products for hair growth and restoration; Why electric vehicles may make us carsick.

Olympian in 212 AND Classic goes to Olympia again ‪@Durrah1‬ ‪@thedurrah‬ The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro: Mahmood's Journey00:02:10 - Son's Inspiration to Compete00:05:22 - Training and Prep Strategy00:09:08 - Transitioning To Classic00:15:35 - Carb-Up and Peak Week Tactics00:20:15 - Self-Coaching and Cheat Meals00:23:47 - Diet Hacks and Cravings00:24:58 - Estrogen and Cycle Management00:27:09 - Son's Reaction and Viral Moment00:29:47 - Overcoming Defeat and Rebirth00:33:42 - Mental Health and Dopamine Struggles00:43:25 - Celebrity Mental Health Insights00:45:29 - Chasing Dopamine and New Passions00:47:34 - Finding Peace and Purpose00:49:14 - Shrinking the Waist for Classic00:51:53 - Waist Trainer and Vacuum Techniques00:55:59 - Diet and Calorie Management00:58:23 - Carb Cycling for Leg Growth01:00:15 - Pumping and Rice Cake Hacks01:02:25 - Diuretics and Post-Prejudging Meals01:04:01 - Cycle Simplicity and Shrinking Down01:09:25 - Coaching and Cycle Mistakes01:11:33 - Weight Cutting Struggles01:20:29 - Redcon1 Loyalty and Community01:21:51 - Mustache Vibes01:24:40 - Daily Diet Breakdown01:27:00 - Advice for Young PED Users01:30:37 - Bloodwork and Health Monitoring01:33:22 - Managing Prep Fatigue and Cardio01:34:06 - Sleep Struggles and UARS Treatment01:38:11 - Fat Burners and Receptor Refresh01:39:50 - Olympia Game Plan01:42:40- Insulin Sensitivity and GH Timing01:49:48 - First Cycle Stories01:59:55 - Prize Money in Bodybuilding02:00:34 - Classic vs. Open Prize Money02:02:29 - Boosting Classic with Bigger Checks02:05:34 - Open Bodybuilding's Freak Factor02:07:01 - Men's Physique and Audience Draw02:08:52 - Separate Men's and Women's Olympia?02:10:29 - Final Message to the World

Kann man den Hunger einfach wegspritzen? Und was passiert eigentlich, wenn du plötzlich keinen Appetit mehr hast?Die Medien sind voll von Mythen, Halbwissen und Marketing rund um Ozempic, Wegovy und anderen der sogenannten „Abnehmspritzen“. In dieser Episode bekommst du den Überblick, den du brauchst – um Dir eine eigene Meinung zu bilden.Du erfährst:warum viele Menschen nicht zunehmen, obwohl sie mehr essen – und andere schon bei normalen Portionen zunehmen,was GLP-1-Wirkstoffe mit Spielsucht, Alkohol und impulsivem Verhalten zu tun haben,warum viele Patienten nach dem Absetzen der Spritze schneller wieder zunehmen, als sie abgenommen haben,und warum es gefährlich sein kann, unter diesen Medikamenten zwar Gewicht zu verlieren – aber dabei Muskeln zu verbrennen statt Fett.Und wenn Du ohnehin sagst: „Spritze? Kommt für mich nicht infrage“, lohnt diese Episode – weil sie Dir hilft, den Mechanismus hinter Hunger, Sättigung und Gewohnheiten besser zu verstehen. Und damit auch Deinen eigenen Körper effektiver zu steuern.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Mehr zum Thema:Podcast: Folge 502: Ratgeber Nahrungsergänzung – mit Ernährungsmediziner Niels Schulz-RuhtenbergQuellen:Wilding, J. P. H. et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989–1002.Garvey, W. T. et al. (2022). Two-year effects of semaglutide in adults with overweight or obesity: The STEP 5 trial. Nature Medicine, 28(10), 2083–2091.Jastreboff, A. M. et al. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205–216.Ryan, D. H. & Yockey, S. R. (2017). Weight loss and improvement in comorbidity: Differences at 5%, 10%, 15%, and over. Current Obesity Reports, 6(2), 187–194.Marx, N. et al. (2022). GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes. Circulation, 146(24), 1882–1894.Lincoff, A. M. et al. (2023). Semaglutide and cardiovascular outcomes in obesity without diabetes. New England Journal of Medicine, 389(24), 2221–2232.Karakasis, P. et al. (2023). Effect of tirzepatide on renal function in type 2 diabetes: A systematic review. Diabetes, Obesity and Metabolism.Ida, S. et al. (2021). Effects of antidiabetic drugs on muscle mass in type 2 diabetes mellitus. Current Diabetes Reviews, 17(3), 293–303.Wilding, J. P. H. et al. (2021). Impact of semaglutide on body composition in adults with overweight or obesity: Exploratory analysis of the STEP 1 study. Journal of the Endocrine Society, 5(Suppl. 1), A16–A17.Gorgojo-Martínez, J. J. et al. (2022). Clinical recommendations to manage gastrointestinal adverse events in patients treated with GLP-1 receptor agonists: A multidisciplinary expert consensus. Journal of Clinical Medicine Research, 12(1).Tantawy, S. A. et al. (2017). Effects of physical activity and diet control to manage constipation in middle-aged obese women. Diabetes, Metabolic Syndrome and Obesity, 10, 513–519.Jastreboff, A. M. et al. (2023). Triple–hormone-receptor agonist retatrutide for obesity — A phase 2 trial. New England Journal of Medicine, 389(6), 514–526.***Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

Welcome to Ozempic Weightloss Unlocked, your source for the latest news, science, and lived experiences around Ozempic – and how it's transforming the landscape of weight management and health. Semaglutide, the active ingredient in Ozempic, began as a treatment for type two diabetes but quickly made waves for its powerful effect on weight loss. According to Yale University, Ozempic works by slowing stomach emptying and interacting with the brain's appetite regulation centers, naturally decreasing hunger and helping you feel fuller longer. Major clinical trials, as reported by the New England Journal of Medicine, found that people using Ozempic lost on average fifteen percent of their body weight over a sixty-eight-week period. That's a significant shift in the fight against obesity and has inspired a wave of success stories in 2025.Take Maria, a forty-two-year-old mother of two who, after years of struggling with different diets, lost thirty-five pounds in six months after her doctor prescribed Ozempic. She combined her medication with healthy foods and daily walks, gaining more energy and renewed self-confidence. John, a long-time executive living with type two diabetes, lost forty pounds and enjoyed not only improved blood sugar but the feeling of having his life back. Their stories, shared on Yale's health campus, point to the idea that consistency, a holistic approach, and strong support from healthcare professionals and family make all the difference.Ozempic doesn't just bring physical changes. Dr. Daniel Drucker, who helped develop GLP-1 medicines like Ozempic, told Toronto Life that the drug's success has helped validate obesity as a biological, not just behavioral, condition. For many, it's become proof that medical science can help overcome a complex health challenge – not just willpower alone.Globally, Ozempic and its sister drug, Wegovy, are reshaping national health systems like the NHS in the United Kingdom. NHS reports show over three million prescriptions for Ozempic issued annually, a testament to its popularity and potential. Wegovy, which is a higher-dose version designed specifically for weight loss, became available through specialist services in 2024. Healthcare leaders stress, however, that medications like Ozempic should support, not replace, good nutrition and regular activity. A combined approach delivers the best outcomes, and ongoing monitoring is essential to managing both progress and any possible side effects.Speaking of side effects, most users report mild-to-moderate gastrointestinal issues, especially at the start. There are still open questions about the long-term risks, and health authorities caution against unlicensed or cosmetic providers offering Ozempic outside proper medical supervision.In the competitive field of weight loss drugs, new challengers are emerging. According to Drugs.com and recent publications in JAMA Internal Medicine, Mounjaro, which combines GLP-1 and another gut hormone, has shown even greater weight loss than Ozempic in large studies. Nearly eighty-two percent of people using Mounjaro lost at least five percent of their body weight, compared to about sixty-seven percent for Ozempic. There's also a promising newcomer: a once-monthly shot called MariTide, which recent phase two trials show may rival or even exceed Ozempic's results, though it is not yet widely available.Looking ahead, Ozempic and its competitors are not just for type two diabetes or general obesity. A June 2025 study reported by Live Science found Ozempic's active ingredient may even help people with type one diabetes manage blood sugar and lose weight, hinting at a broader impact on medicine in the years to come.That wraps up this episode of Ozempic Weightloss Unlocked. Thank you for tuning in and remember to subscribe so you never miss an update. This has been a Quiet Please production, for more check out quietplease dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.ai

What do Zumba and Greek dancing have to do with bone density? Why should you shave first and soak later? And who gets to decide whether you can have a hysterectomy for health reasons if you haven’t had kids yet? In this episode, Endocrinologist Dr Sonia Davison from Jean Hailes for Women’s Health talks about whether diet and exercise can prevent dementia and what waist circumference has to do with healthy ageing. She also discusses how stomping, sleeping and strength training should all be part of the puzzle as you get older. We also talk about intermittent fasting and how cups of tea with your girlfriends could be just what the doctor ordered. And, is it possible to delay your ‘hormone window of chaos’? THE END BITS For more information on bone density Dr Sonia Davison recommends: Healthy Bones Australia For more information on fibroids Dr Mariam recommends: ask4ufe Sign up to the Well Newsletter to receive your weekly dose of trusted health expertise without the medical jargon. Ask a question of our experts or share your story, feedback, or dilemma - you can send it anonymously here, email here or leave us a voice note here. Ask The Doc: Ask us a question in The Waiting Room. Follow us on Instagram and Tiktok. All your health information is in the Well Hub. Support independent women’s media by becoming a Mamamia subscriberCREDITS Hosts: Claire Murphy and Dr MariamGuest: Dr Sonia DavisonSenior Producers: Claire Murphy and Sasha TannockAudio Producer: Scott Stronach Mamamia studios are styled with furniture from Fenton and Fenton. Visit fentonandfenton.com.au Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Information discussed in Well. is for education purposes only and is not intended to provide professional medical advice. Listeners should seek their own medical advice, specific to their circumstances, from their treating doctor or health care professional.See omnystudio.com/listener for privacy information.

On May 11, 2025, the study “Tirzepatide as Compared with Semaglutide for the Treatment of Ob*sity” was published in the New England Journal of Medicine.This study was, essentially, a cage match between the two newest weight loss drugs to see which one created more weight loss. Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.  This issue will review: 1.    Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes 2.    Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension Meta-Analysis 3.    The Diabetes Prevention Program and Its Outcomes Study: NIDDK's Journey Into the Prevention of Type 2 Diabetes and Its Public Health Impact 4.    Comparative effectiveness of alternative second‐line oral glucose‐lowering therapies for type 2 diabetes: a precision medicine approach applied to routine data 5.    Phase 3 Trial of Semaglutide in Metabolic Dysfunction– Associated Steatohepatitis   For more information about each of ADA's science and medical journals, please visit Diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health

Ozempic is one of the most import new medications in a generation. The scientist who created it is a self-described "nerd," who grew up on a farm in Denmark and has no interest in the limelight. Lotte Knudsen started her career working on laundry detergent enzymes, but eventually joined a team at the Danish pharmaceutical company Novo Nordisk that was tasked with looking for new treatments for diabetes. She was convinced that a recently discovered human hormone called GLP-1 could be made into a powerful medication, not only for Type 2 diabetes, but also for weight loss. It took 20 years of hard work and persistence for her and her team to figure it out, but their creation now shows promise as a worthy foe of heart disease, kidney disease, Parkinson's, alcoholism & Alzheimer's as well. In this episode Lotte Knudsen tells her story, and we hear from two of the other scientists who made critical contributions to this revolution in medicine: Mads Thomsen and Daniel Drucker.

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:Watch: https://youtu.be/QgvADjybQCw[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:02:22 - Podcasting & Bodybuilding Origins00:03:37 - Choosing Engineering Over Bodybuilding00:05:19 - Transition to Medicine & Grad School00:06:28 - The Layers of Medicine00:07:41 - Supplements in Preventive Healthcare00:10:35 - Dr. Trevor's Main Focus Now00:15:06 - How to Use PubMed & Read Research00:17:14 - Red Meat & Misinterpreted Studies00:19:59 - Bodybuilding & Cardiovascular Health00:23:04 - Walking, Cardio & Blood Sugar Control00:26:25 - Steps vs Intense Cardio in Prep & Off-Season00:29:32 - Prioritizing Recovery Over Hardcore Work00:31:10 - New Era of Fitness & Proactive Health00:32:33 - Ferrari Analogy: High Performance Needs More Recovery00:36:42 - Monitoring Blood Pressure Accurately00:38:41 - Being Honest with Your Doctor00:41:18 - Tests & Process for Heart Health00:43:00 - Anti-Inflammatory Diet Basics00:45:34 - Carnivore Diet & False Attributions00:47:01 - Best Diet = Lean Proteins + Veggies + Walking00:51:06 - Gut Microbiome's Role in Health00:52:18 - Processed Sugar vs Natural Sugar00:54:06 - Sugar's Drug-Like Effects on the Brain00:57:35 - Supplements For Heart Health01:01:24 - Advanced Organ Support Supplements01:02:54 - Arachidonic Acid Explained01:05:40 - Fast Metabolism and Risks01:08:01 - Stress, Recovery & Longevity01:09:56 - Health Is a Journey, Not a Destination

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: loads of news from American Diabetes Association Scientific Sessions, GLP1 for T1D, Tech updates, diabetes in space, and more! Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX Top story – looking back at The American Diabetes Association Scientific Sessions conference. I won't recap everything here – but I'll link up to a few more comprehensive article. Here's just a taste! XX A single infusion of a new stem cell-based treatment helped 10 out of 12 people with severe type 1 diabetes stop using insulin, researchers report. The treatment, called zimislecel, was made by Vertex Pharmaceuticals. It's an infusion of lab-grown islet cells. A year after getting the therapy, 10 patients no longer needed insulin shots. The other two were able to reduce how much insulin they needed.  The treatment requires patients to take immunosuppressive drugs, which may raise the risk of infections or cancer in the long run, experts said. https://www.usnews.com/news/health-news/articles/2025-06-24/stem-cell-treatment-may-free-some-with-type-1-diabetes-from-insulin XX New study shows inhaled insulin is safe and effective for children with type 1 diabetes. This is Mannkind's Afrezza, which takes the place of rapid-acting mealtime insulin. Findings indicate that inhaled insulin delivers glycemic control comparable to injected rapid-acting insulin. Inhaled insulin was also associated with less weight gain and slightly higher patient and parent preference scores. These findings add to outcomes shared from INHALE 1 late last year. Based on the findings of the inhaled insulin study, MannKind looks to seek FDA approval to expand Afrezza's indication to children. The company also aims to evaluate inhaled insulin at diagnosis and in automated insulin delivery systems in additional studies. https://www.drugdeliverybusiness.com/study-mannkind-inhaled-insulin-safe-effective-children/ XX Positive outcomes in two different studies looking at GLP 1 medications for type 1. Semaglutide – brand name Ozempic or Wegovy - reduced glucose levels and weight among patients with type 1 diabetes and obesity. 26-week, double-blind trial of 72 adults, those taking Ozempic spent More than 70% time spent in sensor glucose range (70-180 mg/dL) Less than 4% time spent in hypoglycemia (

There are serious potential side effects to GLP-1 weight-loss drugs.

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we're diving into a topic that's been everywhere lately: GLP-1 medications like semaglutide and tirzepatide for weight loss. You may know them by names like Wegovy, Ozempic, Mounjaro, or Zepbound. I want to give you a clear, realistic picture of what to expect—because while the media loves to highlight the dramatic before-and-after photos, the real journey can be slower and more nuanced for some. So in this episode, we're going to talk about the truth—what these medications can do, what they can't, how long things really take, and what you need to know to set yourself up for success. Not hype, not magic promises—just real, honest insight to help you understand the process. Let's get into it. How GLP-1 & GIP/GLP-1 Agonists Work So first things first—how do these meds work? Semaglutide is a GLP-1 receptor agonist, and tirzepatide is a dual GIP and GLP-1 receptor agonist. Basically, they mimic natural hormones in your body that help regulate blood sugar, slow digestion, and—most importantly for weight loss—reduce appetite and improve satiety. That means you feel fuller faster and stay full longer. You're not obsessing over food like before. And that's powerful. But—and this is a big one— these peptides don't magically erase years of weight gain overnight. What they do is help make weight loss easier by reducing hunger and supporting your metabolism—but they don't do all the work for you. It's important to remember they're a powerful tool, not a replacement for your efforts. You're still in control of your choices, habits, and long-term success. Why We Titrate the Dose—and What "Therapeutic Dose" Means Now, let's talk about dosing. When you start Wegovy, you don't start at the highest dose. It's gradually increased over several weeks to give your body time to adjust and to help reduce side effects like nausea or stomach upset. The usual schedule looks like this: You'll start with 0.25 mg once a week for the first month. Then it increases every four weeks—0.5 mg, then 1 mg, then 1.7 mg. By week 17, most people reach the full dose of 2.4 mg once a week—that's the dose shown in studies to lead to the most consistent weight loss, with many people losing around 15% of their total body weight over about a year. But here's the thing—not everyone follows this path exactly, and that's okay. Some people need to slow down or stay longer at a lower dose if they're having side effects. Others may need to increase sooner if they're not seeing appetite changes and are tolerating the medication well. And even though 2.4 mg is considered the “therapeutic dose,” not everyone needs to reach it. Some people feel great and lose weight at a lower dose—and if that's you, that's your sweet spot. The real goal is to find the lowest effective dose that controls your hunger, helps you lose weight at a steady pace, and keeps side effects to a minimum. This isn't a one-size-fits-all journey, and pushing through side effects just to hit the max dose isn't necessary—or safe. Your best dose is the one your body handles well and helps you make progress. *How Much Weight Can You Expect to Lose—and How Fast? Let's take a look at the clinical studies. In large trials, people on semaglutide lost about 15% of their total body weight over 68 weeks. For tirzepatide, it was even higher—20% or more in some cases. But here's the thing—those results happened over a year to a year and a half. Not 6 weeks. Not 3 months. It's a marathon, not a sprint. Also, most of the weight loss doesn't happen during the titration phase. You may see some weight loss early on, especially if your appetite plummets. But the bulk of the weight loss happens once you reach and maintain your therapeutic dose. Why Everyone's Journey Looks Different I can't stress this enough—everybody's journey is different. Some people feel zero hunger from their very first injection. Others don't notice a big change until week 10 or 12. Some drop 10 pounds in the first month. Others lose two pounds and feel discouraged. All of those experiences are normal. Your age, hormones, medications, stress levels, sleep, and past diet history? They all play a role. And let's be real—gaining 20, 50, or 100 pounds didn't happen in a few weeks, right? It likely took months or even years of lifestyle habits, hormonal shifts, emotional eating, or underlying conditions. So we have to give ourselves that same grace and patience when we're trying to take the weight off—even with medical support. Navigating Side Effects and Setbacks Let's talk about the side effects. Nausea, constipation, acid reflux, bloating—yeah, these are pretty common as your body adjusts. And sometimes, those symptoms are your body's way of saying: Hey, slow down. Pushing through intense side effects just to hit a higher dose isn't the goal. In fact, it's not safe. You want the lowest effective dose that keeps your appetite under control, the weight coming off gradually, and your side effects minimal or nonexistent. If you need to pause treatment to let your gut settle or even go back down a dose, that's not failure. That's smart, safe self-care. We're in this for the long haul. Trial and Error with Food—and That's OK One part of this journey that catches people off guard is how sensitive your stomach becomes—especially to certain foods or drinks. Greasy or fried foods, spicy meals, carbonated drinks, alcohol—these can all be triggers for nausea or even vomiting while you're on this medication.  And it makes sense when you think about it: the medication slows down how quickly food and drink leave your stomach. So if you're eating or drinking things that already tend to irritate the stomach lining, the effects can hit harder and last longer. Even if those foods didn't bother you before starting treatment, they might now. It's just one of those things your body has to adjust to, and it may take some trial and error to figure out what still works for you. What is Healthy, Sustainable Weight Loss? So what's a healthy pace of weight loss? In general, 1 to 2 pounds per week is considered safe and sustainable. But on GLP-1s, that might vary. Some weeks you may lose 3 pounds. Some weeks, nothing. And guess what? That's normal. You're looking for overall downward trends, not perfection. The goal here is steady, sustainable fat loss—not dropping weight so quickly that you feel miserable, drained, or start losing muscle. Remember, we're not chasing “skinny”—we're aiming for strong, lean, energized, and healthy. And I know we've talked about this before, but it's worth repeating: exercise is not optional when you're on a GLP-1. It's a must. When you lose weight, you lose both fat and muscle. If you're not actively working to maintain or build muscle, you risk becoming weaker and slowing down your metabolism in the process. We want to keep the muscle you have—and ideally, build more—so your body stays strong and your results last. What Is a “Non-Responder”? Now let's touch on something important: what if the medication doesn't seem to work? Let's talk about what it means to be a “non-responder” on a GLP-1 medication like Wegovy or Zepbound. In clinical terms, a non-responder is someone who has been on their therapeutic dose for at least 3 months and has lost less than 5% of their total body weight—even though they're taking the medication correctly and making lifestyle changes like adjusting their diet, increasing physical activity, and managing stress or sleep. Let's break that down with an example: If someone weighs 200 pounds, 5% of their total body weight would be 10 pounds. So if they've been on their therapeutic dose for 12 weeks and have only lost, say, 4 or 5 pounds—despite doing everything right—they may be considered a non-responder. But as we mentioned before, everyone's therapeutic dose may be different. The therapeutic dose isn't just the maximum dose like 2.4 mg of semaglutide or 15 mg of tirzepatide. It's the dose at which you personally begin to experience consistent appetite suppression, weight loss, and minimal side effects. For some people, that may happen at 1 mg of semaglutide. Others may not feel much of a difference until they reach the full 2.4 mg. Some may even respond better at 1.7 mg and not tolerate the higher dose at all. That's why we titrate slowly, monitor your symptoms, and assess both how you feel and how your body is responding. So how do we know if you've reached your therapeutic dose? We look at things like: Has your appetite significantly decreased? Are you noticing earlier fullness or fewer cravings? Are you losing weight consistently over time Are side effects tolerable or nonexistent? If the answer is yes, you're probably at your therapeutic dose. But if the answer is no—if your hunger hasn't changed much, the scale hasn't moved, and you're not noticing any shift in your eating patterns after 3 months on a stable, higher dose—it might be time to re-evaluate. That could mean adjusting the dose, checking for other health issues that might be interfering (like thyroid problems or certain medications), or even considering a different treatment approach. *So what are my final thoughts?  Your journey is unique. Not everyone responds the same way, and that's okay. The key is finding what works for your body, not just what the label says. These medications can absolutely change lives. But they're not magic. They work with your efforts—not instead of them. You'll need to be patient, flexible, and kind to yourself along the way. You may need to tweak your dose, change your food choices, or give your body time to adjust. That's part of the process. And remember—this isn't just about weight loss. It's about reclaiming your health, confidence, and energy. So take it one step at a time. Celebrate every win. And know that slow progress is still progress. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Until next time, be well, be patient, and keep showing up for yourself. And as always, have a happy, healthy week.

GLP-1s can do wonders, but optimizing diet and exercise to the mix maximized their impact. Discover how lifestyle changes can supercharge your results.   APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com

Listen in as Joseph Kim, MD, MPH, MBA; Manish Shah, MD; Martha Grugel, MA, discuss how they manage the prior authorization process for antiobesity agents to improve the quality of their care delivery, including:The information to collect during patient visitsThe available resources to help you submit prior authorizationsThe supporting documents that are often necessary to accompany prior authorizationsHow to address denials and appealsWhen to access manufacturer-based or foundation-based financial assistancePresentersJoseph Kim, MD, MPH, MBAPresidentQ Synthesis, LLCNewtown, PennsylvaniaManish Shah, MDClinical Associate Faculty MS1 PreceptorUniversity of Florida College of MedicineGainesville, FloridaMartha Grugel, MAMedical AssistantWesley Chapel, FloridaLink to full program: https://bit.ly/45P0v8z

Join us as we review recent practice-changing articles on the effect of combination statin and ezetimibe in reducing myalgias, male partner treatment for BV, semaglutide for MASH/liver fibrosis, exercise and cancer risk, and cytisinicline for smoking cessation. Fill your brain hole with some delicious apps and entrees from our spring Digests! Featuring Paul Williams (@PaulNWilliamz), Nora Taranto (@norataranto), special guest epidemiologist Alexander Chaitoff (@alexchaitoff) and Matt Watto (@doctorwatto). Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Credits Written and Hosted by: Nora Taranto MD; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP, Matthew Watto MD, FACP, Alex Chaitoff MD MPH  Cover Art: Nora Taranto MD Reviewer: Leah Witt MD  Technical Production: Pod Paste Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments Intro, disclaimer Self-collected HPV tests for cervical cancer screening  Semaglutide for MASH/Liver Fibrosis Male Partner Treatment for BV  Statins plus ezetimibe versus high-dose statins alone for statin-associated muscle symptoms  Exercise and Colon Cancer Risk  Cytisinicline for Smoking Cessation  Outro Sponsor: FIGS Curbsiders listeners can get 15% off. Just go to wearFIGS.com and use code FIGSRX Sponsor: Quince Go to Quince.com/curb for free shipping on your order and 365 day returns.  Sponsor: Continuing Education Company Curbsiders listeners get 45% off select online courses with promo code Curb45, through July 30. You can also use Curb30 for 30% off all webcasts and on demand replay courses. Check it all out at CMEmeeting.org/curbsiders.

Learn what age-related macular degeneration (AMD) isWhat causes AMDThe types of AMDThe update on NAION - listen to last year's podcast all about itWhy we aren't too concernedClick here to join Dr. Spencer's online clinic VineyardClick to read the JAMA AMD articleClick to read the Ophthalmology journal AMD article

“Obesity Rx

Send us a textWelcome back Rounds Table Listeners! Today we have another special episode— Trial Files turns two years old this June, and we're celebrating with an episode summarizing the Top 5 RCTs in the Trial Files catalogue to date. Dr. Mike Fralick takes us through five trials in 15 minutes. Here we go!1. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (0:00 - 3:08)2. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia (3:09 - 5:37)3. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis (5:38 - 8:33)4. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (8:34 - 11:22)5. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (11:23 - 13:23)Happy 2nd Birthday, Trial Files!A free monthly newsletter on practice-changing trials, delivered straight to your inbox-- sign up at https://trialfiles.substack.com/ (13:24 - 14:19)Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Feeling stressed, fatigued, or like you've lost your edge? It's likely your hormones. In this episode, Marine Corps veteran and entrepreneur Micah Berg reveals his exact protocol for reversing burnout with Testosterone Replacement Therapy (TRT) and cutting-edge peptide treatments.    Ready to take control? Download our FREE Hormone Optimization Guide to start boosting your T levels and regaining your energy today: https://pazonamd.com/Hormone_Lifestyle_eBook_V3-24.pdf   Micah's story is a powerful, unfiltered look at how the immense pressure of being an entrepreneur, veteran, and family man can tank your testosterone and spike your cortisol. But more importantly, he shares the specific steps he took to reclaim his health, energy, and drive.   If you've ever wondered about hormone optimization, this is the episode you can't afford to miss.   -- IN THIS EPISODE, WE DISCUSS --  The silent symptoms of chronic stress and low testosterone most men ignore.  The critical link between high cortisol (stress hormone) and low T.  A real-world comparison of TRT options: pellets vs. injections vs. creams.  Micah's personal experience and results with peptide therapies like Semaglutide. Actionable steps you can take to start your own health transformation journey.

Today we do a round-up of some of the recent semaglutide trials. Does semaglutide ever miss? But what about tirzepatide, which causes even more weight loss?We also review two new critical care trials, FLUID and the UK-ROX, new platelet transfusion guidelines, and a new retrospective study of apixaban vs rivaroxaban vs warfarin. Oral Semaglutide for Diabetes with Cardiovascular Disease or CKD (SOUL)Semaglutide for Peripheral Artery Disease (STRIDE)Semaglutide for MASH (ESSENCE)Semaglutide vs Tirzepatide for Obesity (SURMOUNT-5)Normal Saline vs Lactated Ringers (FLUID)Conservative Oxygen Targets in Mechanically Ventilated Patients (UK-ROX)Platelet Transfusion GuidelinesApixaban vs Rivaroxaban vs Warfarin Music from Uppbeat (free for Creators!): https://uppbeat.io/t/soundroll/dope License code: NP8HLP5WKGKXFW2R

Semaglutide medicines for treating diabetes and obesity (like Ozempic, Wegovy and Mounjaro) have recently been observed to make mice more sedentary. Will these drugs have the same effect on humans? And how were semaglutides discovered, and what does that say about public financing of basic research? Finally, Dr. Bruce A. Scott, a Louisville physician and outgoing President of the American Medical Association gave a fiery address to the association on June 6th. What was he angry about? Here is the full video of Dr. Scott's talk to the AMA: https://www.youtube.com/watch?v=XIEy5ySMDHE ‘Bench Talk: The Week in Science' is a weekly program that airs on WFMP Louisville FORward Radio 106.5 FM (forwardradio.org) every Monday at 7:30 pm, Tuesday at 11:30 am, and Wednesday at 7:30 am. Visit our Facebook page for links to the articles discussed in this episode: https://www.facebook.com/pg/BenchTalkRadio/posts/?ref=page_internal

PhD in synthetic chemistry, the Product Formulator for Supplement Needs, and fitness industry renowned Pharmacologist for his no-nonsense approach in bodybuildingThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com2:19 Bodybuilding Pharmacology and Dosing4:53 Brain Health and Long-Term Risks7:29 Muscle Building and Genetic Factors10:03 Cholesterol and LDL Impacts12:14 Podcast Setup and Equipment Upgrades14:34 Hair Transplant Journey24:23 Hair Loss Causes and Treatments34:59 Post-Transplant Recovery and Rebound39:31 Epigenetics and Muscle Memory43:04 Ethical Questions on Genetic Enhancement45:40 Enhanced Games Debate50:09 Dosing Challenges in Enhanced Sports52:32 Data Collection and Human Experimentation55:16 Genetic Variance and Elite Athletes59:04 Neurodegeneration and PEDs1:07:08 Oxidative Stress in Bodybuilding1:09:37 Sleep and Brain Detox1:18:01 Nutrition for Oxidative Stress1:19:02 Melatonin as an Antioxidant1:21:13 Melatonin Dosing and Effects1:24:51 Melatonin and Sleep Support Supplements1:28:22 Magnesium and Sleep Health1:31:23 Sleep Apnea and Neural Health1:36:30 Frequent Urination at Night1:46:33 Overheating During Sleep1:59:14 Wrapping Up Oxidative Stress2:00:33 Neuron Loss and Neurotransmitters2:02:04 Boosting Brain Health with BDNF2:04:08 Peptides for Neural Growth2:09:14 Oxidative Stress and Supplements2:12:34 Neuroprotection Strategies2:19:56 EMF and Environmental Stressors2:22:12 Mitochondrial Dysfunction and Aging2:24:55 Balancing Oxidative Stress2:28:32 Steroids and Muscle Growth Rates2:38:54 HDL and LDL Control Ancillaries2:41:34 Statins and LDL Oxidation2:47:36 Antioxidants and Plaque Formation2:54:10 Balancing Cholesterol Levels2:58:35 CT Scans for Heart Health3:03:54 Heart Health Supplements3:06:48 Mitochondrial Stack Under 303:16:27 Balanced Diet in Prep3:20:24 Omega-3 and Fish Oil Quality3:23:36 Podcast Wrap-Up

The CHALLENGE trial at ASCO 2025 showed that increased physical activity improves survival rates in colon cancer patients, with the exercise group demonstrating better health outcomes and survival rates compared to those receiving only health education. A phase 3 trial in The New England Journal of Medicine found that semaglutide significantly improves liver conditions in MASH patients, showing better resolution of steatohepatitis and fibrosis improvement compared to placebo. Additionally, a study in the NEJM revealed that combining finerenone and empagliflozin offers enhanced kidney protection in patients with chronic kidney disease and type 2 diabetes, significantly reducing urinary albumin levels.

In this quick hits episode, you are going to hear a clip from my most downloaded episode to date! I take a deep dive into the world of GLP-1s, the revolutionary weight loss medications that have captivated the health and wellness scene. We all know that whenever there's a new breakthrough, doubts and controversies tend to emerge, leaving us wondering if it's too good to be true. But fear not! In this show, I am here to unravel the mysteries and shed light on these drugs like never before. My goal is to address your concerns, provide clarity, and empower you with the knowledge to make informed decisions. I will share my own journey on tirzepatide plus client experiences. Whether you're considering these medications or simply seeking accurate information, this episode will be your ultimate resource. So sit back, relax, and join me on this captivating journey into the realm of GLP-1s. By the end of this podcast, you'll have a comprehensive understanding of the pros and cons, equipping you with the insights to navigate this topic with confidence. It's time to separate the facts from the myths and arm yourself with the information you need. Listen to the full episode here.   Sponsors Get $100 off your CAROL bike with coupon code HORMONE here.     Are you in peri or post menopause and looking to optimize your hormones and health? At Hormone Solutions, we offer telemedicine services and can prescribe in every U.S. state, as well as in British Columbia, Alberta, and Ontario in Canada.   Visit karenmartel.com to explore our comprehensive programs: Bioidentical Hormone Replacement Therapy Individualized Weight Loss Programs  Peptide Therapy for weight loss    Interested in our NEW Peptide Weight Loss Program? Join today and get all the details here.   Join our Women's Peri and Post Menopause Group Coaching Program, OnTrack, TODAY!   To our nursing audience members, our podcasts qualify for nursing CE @ RNegade.pro. Provide # CEP17654.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

The Clay Edwards Show Live at Men's Health & Women's Wellness of Mississippi Join us for an engaging and informative special live edition of The Clay Edwards Show, broadcast directly from the lobby of Men's Health & Women's Wellness of Mississippi, located at 120 Fountains Boulevard, Madison, MS. Host Clay Edwards sits down with Dr. Micah Walker for an in-depth conversation about men's and women's health, covering a wide range of topics from testosterone therapy and weight loss to innovative treatments and the importance of proactive healthcare. In this episode, Clay and Dr. Walker dive into the transformative benefits of semaglutide and tirzepatide, GLP-1 agonist medications known for their effectiveness in weight loss. They discuss how these drugs not only aid in shedding pounds but also help curb alcohol cravings and improve mental relationships with food by targeting the brain's dopamine reward center. Clay shares personal anecdotes about his own health journey, including how semaglutide has helped him manage cravings and maintain a healthier lifestyle, while Dr. Walker provides expert insights into the science behind these medications and their potential future FDA indications for addiction treatment.   The conversation also explores the critical role of testosterone therapy, particularly for men experiencing low levels due to age, lifestyle, or medical conditions. Dr. Walker emphasizes the importance of identifying the root cause of low testosterone through comprehensive blood work, highlighting conditions like sleep apnea, obesity, or past use of anabolic substances that can contribute. He addresses common concerns about testosterone therapy for older men, debunking myths and explaining its safety and benefits when medically supervised. The discussion extends to younger men with low testosterone, with Dr. Walker advocating for a thorough evaluation to determine whether lifestyle changes or medical intervention is the best course.   Clay and Dr. Walker also tackle the controversial topic of peptides, addressing the hype surrounding these compounds in fitness and anti-aging circles. Dr. Walker cautions against the use of unregulated peptides like melanotan and SARMs, sharing a sobering story of a patient who suffered severe complications from an unsafe source. He stresses the importance of sticking to FDA-approved treatments from reputable sources, such as brand-name medications or trusted compounding pharmacies, to ensure safety and efficacy.   Beyond men's health, Dr. Walker introduces the services offered at Women's Wellness of Mississippi, located upstairs in the same facility. This concierge primary care clinic caters to women aged 30-65, offering annual wellness exams, hormone therapy, weight loss programs, and aesthetic treatments like Botox, fillers, laser hair removal, and medical-grade skincare with ZO Skin Health. Innovative devices like the Emsculpt Neo (equivalent to 20,000 sit-ups in 30 minutes) and Emsella (for stress incontinence) are highlighted as non-invasive solutions for women looking to reclaim their health and confidence post-childbirth or as they age.   The episode underscores the clinic's unique approach to healthcare, designed to fit the busy lives of men and women. Men's Health & Women's Wellness of Mississippi offers a membership-based model with no long-term contracts, providing affordable, transparent pricing and minimal wait times. Clay shares how this model has been a game-changer for him as a self-employed individual, combining a high-deductible insurance plan with the clinic's membership for cost-effective, accessible care. Dr. Walker explains how the clinic serves as a primary care provider, managing conditions like diabetes, hypertension, and sleep apnea, and fostering a comfortable, judgment-free environment for patients to discuss sensitive issues, including erectile dysfunction, with affordable solutions like generic Viagra and Cialis.   Throughout the episode, Clay and Dr. Walker address broader healthcare issues, from the complexities of the pharmaceutical industry to the loss of trust in medical institutions post-COVID. They discuss the importance of patient choice, the risks of unverified online supplements, and the need for honest, transparent communication between doctors and patients. The episode wraps up with a call to action for viewers to prioritize their health, emphasizing the clinic's welcoming atmosphere—complete with deer heads, a leg lamp, and a “reception area” rather than a traditional waiting room.   For more information or to schedule a visit, check out MensHealthMS.com or call 1-844-4MVPTRT. Don't miss this lively, candid discussion packed with practical health insights and a behind-the-scenes look at a clinic reimagining healthcare for men and women in Madison, Mississippi.   Note: This episode was recorded on June 10, 2025, and reflects the latest services and perspectives from Men's Health & Women's Wellness of Mississippi.

Bryan Moskow: MS Organic & Biochemistry UCF/GT, PhD Student at Georgia Tech, Offseason/Prep Protocols & Hormone OptimizationThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro01:47 - Steroids and PEDs in Bodybuilding  02:59 - Podcast Setup and Audio Talk  03:41 - Science Without an Agenda  04:22 - GLP-1 and GLP-300008:19 - Insulin, Diets, and Brain Health  10:26 - Berberine and Supplement Bioavailability  13:04 - Beta-Alanine and Sodium Bicarbonate  14:59 - Citing Studies and Research Quality  17:32 - Natural Alternatives to Pharmaceuticals  19:34 - Esters and Compound Solubility  21:29 - Brian's Bodybuilding Journey  24:56 - Steroid Protocols and Half-Lives  30:34 - PCT and Fertility Strategies  38:44 - HCG and Male Contraception  41:53 - SARMs and Their Risks  46:08 - GHB as a Supplement  47:40 - GHB Risks and College Stories  50:32 - Prescription GHB and GABA Dangers  51:48 - Long-Term Effects of Sleep Meds 

6th at Olympia (2019), 3rd at Arnold, entrepreneur, husband, and father @stevekucloThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro  02:38 - Challenges of Monetizing Bodybuilding  04:09 - Transitioning to Health & Wellness  05:37 - Bodybuilding Prep & Off-Season Strategies  07:46 - Truth About Steroid Dosages  09:19 - Training as the Game Changer  11:15 - Female Trainers & Intensity  12:54 - Early Bodybuilding Journey & Mentorship  16:33 - Building Muscle Over Time  18:59 - Nutrition for Growth vs. Longevity  23:30 - Shifting to Health-Conscious Bodybuilding  26:20 - Maintaining Insulin Sensitivity  29:27 - Optimizing Testosterone Levels  32:20 - Reducing Inflammation with Supplements  37:39 - Glutathione & Detox Support  39:49 - Smarter Supplement Choices  41:03 - B Vitamins for Inflammation & Sleep  43:10 - Science-Based Training & Apps  45:56 - When to Retire from Bodybuilding  50:40 - Health Markers to Monitor  53:37 - Genetic Testing & Alzheimer's Prevention  56:38 - Brain Health & Mental Stimulation  58:20 - Journey into Bodybuilding & Firefighting  1:02:22 - Building a Fitness Business  1:08:56 - Managing Allostatic Load  1:11:16 - Stress & Anxiety in Competition  1:13:51 - Pushing Limits as a Firefighter  1:15:47 - Early DC Training Days  1:17:14 - Evolution of Training Methods  1:19:50 - Balancing Intensity & Smart Lifting  1:21:16 - High-Volume Heavy Training  1:23:27 - Science vs. Bodybuilding Methods  1:26:22 - Off-Season Testosterone Strategy  1:31:53 - Health-Focused Bodybuilding  1:32:56 - Favorite Bodybuilding Show  1:34:32 - Comeback & Boxing Plans  1:36:01 - Regenerative Medicine Tips  1:37:35 - Genetics & Strength Secrets  1:39:51 - Craziest Pre-Contest Cycle  1:41:32 - Project Super Heavyweight  1:43:57 - Top 5 Training Exercises 1:45:26 - Toughest Firefighting Moments  1:47:07 - TRT Plus Approach  1:50:28 - Low-Dose Transformation  1:52:57 - Dealing with Online Haters  1:54:01 - Hair Loss & Restoration  1:57:03 - Time Management Tips  1:59:01 - Life-Changing Final Message  2:02:11 - Thanks  

We are beginning a new series today. John and Adam will discuss a couple of articles we found interesting. Please let us know your thoughts. This week:Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated SteatohepatitisTiotropium Initiation and Dementia Risk in Chronic Obstructive Pulmonary Disease This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Episode Highlights With ShayThe common problems with most conventional diet models What's going on when we feel like we're doing everything right but nothing is changing We start losing muscle in our 30s if we aren't working to increase it. How this affects metabolism and what to do about itThe problems with calories in and calories out and why there's more to the storyMindset shifts away from restriction to fueling the bodyWhat a reverse diet is and how it can be so helpful!Why protein is so important and what the data actually saysHow to build muscle as we age and the importance of strength training When those pieces don't work: addressing deeper variables like gut health, hormones, liver health, parasites, etc.Her take on semaglutide and alternative optionsResources MentionedThe Body Bulletin on InstagramThe Clean Eating Challenge