Podcasts about semaglutide

In December 2017, the FDA approved a new injectable drug to treat type 2 diabetes called semaglutide, which you likely know by its brand name: Ozempic. A few years later, during the pandemic, Wegovy, a drug with a higher dose of the same active ingredient, was approved specifically for chronic weight management. Soon after, people taking Ozempic started reporting a dramatic, even “life-changing” weight loss. Ozempic is now a bona fide blockbuster. So what's the science behind these “wonder drugs” that apparently 1 in 10 of us could end up using? They have the potential to have so many positive effects on our lives, from treating Alzheimer's disease and addiction to changing our relationship with consumption but, like with most things, they also come with risks.Send us your science facts, news, or other stories for a chance to be featured on an upcoming Tiny Show and Tell Us bonus episode. And, while you're at it, subscribe to our newsletter!Links to the Tiny Show and Tell stories are here and here. All Tiny Matters transcripts and references are available here.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Olympian, 6x IFBB Pro Champion, & best of all Chris Bumstead's brother in lawThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro  03:02 - Switching to Patrick & European Secrets  11:03 - Back-to-Back Competing  20:18 - Minimal Water Manipulation & Sweating on Stage  22:35 - Nick and Derick  39:57 - Iain on Rebounds  49:51 - Iain Almost Quitting Bodybuilding and Meeting Melissa  1:05:04 - TREN  1:12:51 - Iain's Relationship with Compounds Throughout His Career  1:16:49 - Different Training Methods & Iain's Opinion  1:34:58 - GLP-1s  1:48:51 - How People Look vs. Their Personalities  2:00:27 - Coaching Chris Bumstead  2:14:53 - Iain's Best Body Part  2:26:46 - Breakup Advice for Bodybuilders  2:27:56 - Bodybuilders' Fertility  2:31:57 - HCG for Fertility  2:34:21 - Growth Hormone  2:39:45 - Iain's Best Offseason  2:44:31 - Offseason Gear Discussion  2:52:13 - Most Bodybuilders Having Girls & Iain's Preference&

In this episode of the Root Cause Medicine Podcast, Dr. Carrie Jones sits down with seasoned compounding pharmacist Sara Hover, RPh, to demystify the world of personalized medications. They dig into how compounding pharmacies offer tailored solutions for hormone therapy, acne, hair loss, weight loss, and more—and why this approach can be life-changing for patients who've hit dead ends with conventional medicine. Sarah shares eye-opening stories, from hormone creams and sublingual weight loss medications to pediatric popsicles and custom thyroid solutions, showing just how flexible and powerful compounding can be. What You'll Learn: - What compounding pharmacies actually do—and why it matters - Why the finished compounded meds aren't FDA-approved (and why that's okay) - How bioidentical hormone therapy transforms women's health - Solutions for allergies to common fillers like red dye or peanut oil - Fun and effective delivery forms: lozenges, topical creams, even popsicles - Hair loss, acne, eczema, and anti-aging compounding options - The surprising science behind sublingual GLP-1s for weight loss - How to find (or help your doctor become) a compound-friendly provider Sara Hover, RPh is a compounding pharmacist with 30 years of experience and a specialty in hormone replacement therapy. She serves as a lead educator at PCCA, where she trains pharmacists and providers on the latest in compounding innovations. Sarah is passionate about personalized, patient-centered care—and believes no one should be told they're "crazy" when a tailored medication might be the real solution. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Ever wondered how people make dramatic body transformations that actually last? In this raw and honest episode, Dave Kennedy opens up about his five-year journey from 320 pounds to the best shape of his life at age 42."How do you do it?" Dave reveals it's not about quick fixes or miracle diets, but rather a "system of disciplines, a system of regiments, a system of consistency" built gradually over time. Both hosts break down the common misconceptions around fitness transformations, explaining why dramatic overnight changes rarely stick. Instead, they advocate for building small, sustainable habits that eventually become lifestyle changes.The conversation tackles the hierarchy of importance in fitness: why food management trumps exercise when starting out, how to separate the roles of calorie management, cardio, and resistance training, and the vital importance of patience. Dave shares candid insights about formerly weighing 320 pounds and how tracking calories fundamentally changed his relationship with food, while Ben offers practical frameworks for approaching fitness as a long-term journey rather than a quick sprint.They don't shy away from discussing controversial topics like GLP-1 agonists (Semaglutide, Tirzepatide), acknowledging their benefits while emphasizing they're not substitutes for building proper habits. Perhaps most powerfully, they explore how community support creates accountability and knowledge-sharing that dramatically increases success rates.Whether you're just starting your fitness journey or trying to break through a plateau, this episode delivers actionable wisdom from two people who've both lived the transformation process. Subscribe, share with someone who needs to hear this message, and join us in building sustainable systems that change lives.Support the showCheck out Overclock and Protein Protocol hereWant to know more about coaching? Book a call with Ben here Where to find usWe Hack Health: TwitterWe Hack Health: InstagramWe Hack Health: Discord

Can the Microbiome Replace Ozempic? Two Experts Weigh In on a Radical Theorywith Dr. Gary Pepper & Mary Gocke, RDN, CDN, CHTAre we overlooking the natural power of the gut microbiome in managing weight and metabolism?In this eye-opening conversation, Dr. Gary Pepper — a seasoned endocrinologist — teams up with renowned nutritionist and functional medicine expert Mary Gocke to explore whether the body's own microbiome might one day rival pharmaceutical GLP-1 drugs like Ozempic and Wegovy. From nutritional strategies to protect muscle and bone during weight loss, to the role of akkermansia and polyphenols in boosting natural GLP-1 production, this discussion offers a radically fresh perspective on sustainable metabolic health.Topics covered in this episode include:What GLP-1 medications like Ozempic actually do — and what they don'tWhy weight loss can lead to malnutrition, muscle loss, and even bone density declineHow the gut microbiome — especially Akkermansia muciniphila — may support natural GLP-1 productionThe critical importance of dietary fiber, polyphenols, and prebiotics in metabolic healthHow protein needs shift during rapid weight loss and how to calculate your target intakeEarly evidence for and against the long-term use of GLP-1 drugsThe promising but controversial concept of microdosing and tapering off GLP-1sSimple strategies to protect your body from the side effects of medical weight lossWhy resistant starches (like cooled potatoes and rice) might actually help your microbiomeThe silent risk of osteoporosis from poorly managed weight lossWhether you're currently on a GLP-1 medication, considering one, or exploring natural alternatives, this candid and science-based conversation will equip you with insights not found in mainstream media.

Brandon Eisenlauer, aka  @BiohackingUThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 – Intro08:28 – Neuro-toxicity of popular PEDs (19-nors, Tren, etc.)11:42 – Brain-basics: Neuro-steroid support16:18 – Dopaminergic Life & Consequences21:32 – Real Risk of Bodybuilding, Rest & The Right Way27:04 – Managing Mental Stress: Meditation & Mindful Break38:30 – Gen Z, Motivation Gaps & “Just Go Live Life”41:17 – Independence & Growth42:46 – Psychedelics & Neuroplasticity43:45 – Hustle Culture vs Balance46:40 – Cultural & Political Extremes48:40 – Finding Balance in Bodybuilding52:19 – Conscientious Growth53:50 – Brain Protection Strategies57:01 – Serotonin & SSRI Benefits58:33 – Cholinergic, Sleep Support & GABA System1:03:30 – SSRIs Stigma & Pharma Bias1:12:45 – Best Cycle Principles1:19:38 – Pharmacology Caveats & Nuance1:25:25 – Finding Reasons Is Hard & Adaptation1:27:52 – Mitochondrial & Estrogenic Peptides1:36:14 – Stimulant Cycling Strategy & Risks1:47:10 – Injectable Amino Blends1:52:17 – Peptide Safety & Cancer1:57:36 – Skin Health & Peptides1:59:46 – The Final Question

Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, for The Wright Report: Friday Headline Brief—heavy on news, light on analysis—to kick off your weekend with the stories shaping America and the world. Trump's Middle East Tour Draws Unlikely Praise – Top Obama and Biden officials, including Ben Rhodes and Rob Malley, applaud Trump's bold diplomacy in Syria, Gaza, and with Arab partners. Even Democratic Rep. Jim Himes admits Trump “played the Middle East pretty darn well.” Gaza “Freedom Zone” and a Rift with Apple – Trump floats the idea of the U.S. taking over Gaza. He also blasts Apple CEO Tim Cook for moving production to India, accusing the company of betraying American workers. China Floods U.S. with Goods While Hoarding Minerals – Despite the tariff truce, China withholds critical rare earth exports while ramping up production of consumer goods—especially for Halloween and Christmas. Xi Jinping mocks America's dependency on cheap imports and takes shots at Trump in front of Latin diplomats. Germany Bows to Trump's NATO Demands – In a surprise move, Germany pledges to meet Trump's 5% defense spending target, shocking European allies and boosting defense stocks. GOP Pushes Remittance Tax, Mexico Furious – A new Republican proposal would tax wire transfers to fund a $5T tax package. Mexico's president and senate condemn the idea as discriminatory and fear it will push money transfers underground. Supreme Court Grills Trump Admin on Citizenship Case – Justices express skepticism over Trump's executive order to end birthright citizenship and the broader issue of universal injunctions. Medical Breakthroughs: Fentanyl Deaths Decline, GLP-1 Drugs Help Alcoholics and Liver Disease – CDC data shows overdose deaths are down. Semaglutide shows promise in treating alcoholism, liver disease, and may reduce Alzheimer's risk. Prostate Cancer Treatments Improve, Exercise Lowers Risk and Aids Recovery – New research supports shorter, safer radiation schedules, while exercise helps reduce complications, dementia risk, and cognitive decline. "And you shall know the truth, and the truth shall make you free." – John 8:32

Taking Ozempic or Wegovy but still feeling bloated, exhausted, or stuck with your weight? In this episode of Beyond Diagnosis, host Rita De Michele interviews Nutritional Therapist Joanne Posey to break down the missing piece of the GLP-1 puzzle: nutrition and lifestyle. Learn what to eat, how to manage side effects, and what women in menopause really need to know to make GLP-1 medications work with their bodies, not against them. If you're ready for lasting results and better health, this is your next step. Connect with Joanne  https://www.instagram.com/lifelessonsnutritionAsk Rita a QuestionWelcome to Beyond Diagnosis, a podcast that will raise your awareness, decisions, and voice for Alternative practices, so you can take back control of your health. By subscribing, you will gain access to content for people who have long-term health issues, and connect with functional, wellbeing and mindset professionals.

Today we're diving into how to source peptides safely.  We'll talk about why where you live matters, how to find a reputable provider, and the red flags to watch out for. So if you've been curious about peptides but unsure where to start, this podcast is for you.  Why Peptides? And Why You Need to Be Cautious So first, what are peptides? In short, they're short chains of amino acids—basically, the building blocks of proteins—that signal your body to perform specific actions. Some stimulate growth hormone, others help with weight loss, repair tissue, or improve cognition. Sounds amazing, right? And they can be. But, only when used safely and under the guidance of a qualified provider. Peptides aren't regulated the way pharmaceuticals are, so it's incredibly easy to run into unlicensed sources, impure peptides, or outright scams. Why Where You Live Matters Let's talk geography for a minute. Depending on where you live—whether that's in the U.S., Canada, Mexico, or Europe and other parts of the world—the legal status and availability of peptides vary widely. In the U.S., many peptides are still considered “research chemicals,” meaning they can be sold online but not legally for human use unless prescribed by a licensed provider working with a compounding pharmacy regulated by the FDA. In Canada, peptides are more restricted, and access may require going through clinical trials or specific wellness clinics. Interestingly, in parts of Europe, peptides like BPC-157 have been in clinical use since the 1990s, as it was originally developed and researched in Croatia. So what's the takeaway? The laws in your region affect what's legal, what's safe, and what kind of provider you should be working with. That's why it's important to find someone who not only understands peptide therapy but also works within your country's regulatory framework. How to Find a Reputable Peptide Therapy Provider So now you're wondering: Okay, then who DO I trust? Great question. Let's go over some things you should look for when wanting to start a particular peptide therapy. Credentials Your provider should be a licensed clinician—an MD, DO, PharmD, PA, or NP—with specific training in peptide therapy, functional, or regenerative medicine. Bonus points if they're certified by organizations like SSRP (Seeds Scientific Research & Performance), the A4M (American Academy of Anti-Aging Medicine), or IFM  (Institute for Functional Medicine). Provider Works with Licensed Compounding Pharmacies or Peptide Manufacturers Avoid providers who suggest buying your peptides online or mixing them at home. Thorough Evaluation Process Prior to Treatment The first and most critical step in a full medical workup is gathering a comprehensive medical history. This includes a detailed review of your personal health background—such as any chronic conditions, previous illnesses, surgeries, or hospitalizations—as well as your current medications and supplements. Your provider will also explore your family medical history to identify any contraindications to peptide therapy. Laboratory testing may be obtained if clinically indicated depending on the particular peptide therapy and based on your symptoms, medical history, and treatment goals. Another key component of a full medical workup is the functional assessment, which goes beyond lab numbers to evaluate how your body is actually performing day to day.  This includes an in-depth discussion of your sleep quality, energy levels, cognitive function, mood, libido, and overall sense of well-being. Your provider may also ask about your ability to recover from exercise, your stress resilience, and whether you're experiencing symptoms like brain fog, fatigue, or low motivation. For those seeking peptide therapy for performance or longevity, this assessment helps establish baseline functioning and goals, so treatment can be tailored not just to correct deficiencies, but to optimize quality of life and daily performance. Follow-up Care and Dosing Guidance Peptides aren't one-size-fits-all. You need personalized dosing, cycle recommendations, peptide stacking, and monitoring. If you're not getting that, you're not being cared for safely. Red Flags  “For research only” Let's get real and talk about some red flags you may come across when doing your research. The internet is full of what I like to call “peptide pirates.” These are websites that sell cheap peptides labeled “for research only.” They might even look legit, but here's the thing, there's no regulation, no guarantee of purity or potency, and no support during your peptide therapy journey. Low cost and hidden fees Keep in mind that peptides are often expensive due to several factors. They require complex, specialized manufacturing processes, which include synthesis and purification to ensure quality and purity. Additionally, high-quality peptides are typically produced in small batches by licensed compounding pharmacies or peptide manufacturers, which increases costs. The research and development and regulatory compliance required to ensure their safety and efficacy also contribute to the higher price point.  If the prices from online peptide providers/clinics seem unusually low or too good to be true, there's a high likelihood that the products are either compromised, unregulated, or not what they claim to be. And while we're on the topic of cost, I shouldn't forget to mention hidden fees. You know, the sneaky little charges that pop up after you've been lured in by the words “free consultation.” When you book that initial appointment thinking, “Okay, great. I'll get expert advice, ask a few questions, and figure out if peptide therapy is right for me.” But then what happens? What if you've got more questions after the appointment—maybe you're dealing with side effects, started a new medication and want to be sure there aren't any interactions, or your symptoms have shifted and you're thinking about adjusting your dosage. And just like that, your “free” consultation suddenly comes with a consult price tag. I've personally seen clinics charge $50 just to email a follow-up question or do a “dosage review”. And don't get me started on the “lab interpretation fees.” You either pay for your bloodwork or labs are included, but then they charge you again just to tell you what your results mean.  Cold-chain And lastly, let's not forget that peptides are delicate compounds that require specific storage conditions. Certain peptide providers may not store or ship peptides correctly, affecting their potency and stability. As a general rule, for long-term storage, peptides should be kept frozen in their lyophilized (powder) form to preserve stability. Once reconstituted, most peptides should be stored in the refrigerator and used within the recommended timeframe, typically 2–8 weeks depending on the peptide and diluents used. It's important to avoid repeatedly freezing and thawing, as this can degrade the peptide structure and reduce its effectiveness.  Recap Do your homework. Research providers in your area. Look for peptide clinics or functional or integrative clinics with peptide experience. Ask smart questions. Where do they source peptides? Are the peptides made in a cGMP, FDA-registered facility? What's their follow-up protocol? How do they store and ship their peptides? Trust your gut—and the science. If something feels off, it probably is. Safe peptide therapy is always grounded in evidence and ethical practice. Your health isn't something to gamble with. Peptides can be powerful tools—but only from a trusted source and with guidance. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!

Episode Highlights With ShayThe common problems with most conventional diet models What's going on when we feel like we're doing everything right but nothing is changing We start losing muscle in our 30s if we aren't working to increase it. How this affects metabolism and what to do about itThe problems with calories in and calories out and why there's more to the storyMindset shifts away from restriction to fueling the bodyWhat a reverse diet is and how it can be so helpful!Why protein is so important and what the data actually saysHow to build muscle as we age and the importance of strength training When those pieces don't work: addressing deeper variables like gut health, hormones, liver health, parasites, etc.Her take on semaglutide and alternative optionsResources MentionedThe Body Bulletin on InstagramThe Clean Eating Challenge

The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

Study Link: http://biorxiv.org/content/10.1101/2025.04.17.649402v1.full.pdfGet My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Tirzepatide is more effective for weight loss than semaglutide.Cost-effectiveness is crucial in prescribing weight loss medications.Patients with severe obesity should receive more expensive medications for better outcomes.Both medications show significant benefits for obesity-related conditions.Long-term studies indicate sustained weight loss with both drugs.Gender differences affect weight loss outcomes with these medications.Safety profiles show tirzepatide may be better tolerated than semaglutide.The need for affordable drug pricing is emphasized.Clinical benefits extend beyond weight loss to include metabolic health.Future studies are needed to confirm cardiovascular benefits of tirzepatide.Click here to see the studyClick here to join Dr. Spencer's new online clinic

The first Temu chat.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com

CBS News MoneyWatch correspondent Kelly O'Grady breaks down what to know about the potential financial impact to American consumers after the U.S. and China agreed to temporarily ease tariffs. Music superstar Taylor Swift has been subpoenaed in the ongoing legal dispute between Blake Lively and Justin Baldoni over allegations surrounding the making of their 2024 film "It Ends with Us."  A new study from the New England Journal of Medicine compares two weight loss drugs, Tirzepatide and Semaglutide. CBS News medical contributor Dr. Celine Gounder breaks down the findings. Nicole Scherzinger is making her Broadway debut in the stripped down, modern revival of "Sunset Blvd." She talks with "CBS Mornings" about the show, taking on the role and her first Tony nomination. In an exclusive "Begnaud's America" interview, CBS News contributor David Begnaud speaks with Gus Waltz, the son of Minnesota Gov. Tim Walz, who stole the spotlight during the 2024 Democratic National Convention. He's opening up about that moment and a learning disorder that is often misunderstood. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Os medicamentos injetáveis para emagrecimento, conhecidos como “canetas emagrecedoras”, incluindo Ozempic, Wegovy, Saxenda, Mounjaro e similares vinham sendo vendidos livremente no Brasil, sem a necessidade de prescrição médica. Mas isso vai mudar.A Agência Nacional de Vigilância Sanitária (Anvisa) aprovou uma nova regra para a venda desses medicamentos, que só poderá ser feita mediante apresentação de receita médica em duas vias, sendo que uma delas ficará retida na farmácia - procedimento semelhante ao já adotado para antibióticos.Neste episódio, conversamos sobre as indicações desses medicamentos, seus efeitos colaterais e a importância do acompanhamento médico para o uso correto.Links relacionados:Tirzepatide as Compared with Semaglutide for the Treatment of ObesityComida Sem Filtro #88 – Injetáveis Para EmagrecerComida Sem Filtro #146 – Ozempic: Como Evitar O Reganho De Peso?Comida Sem Filtro #125 – Efeito Ozempic Na Indústria De AlimentosEstamos no Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Dr. Souto⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sari Fontana⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Para ser avisado sobre cada novo episódio e receber os links das matérias mencionadas e as referências bibliográficas por e-mail, cadastre-se gratuitamente em ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drsouto.com.br/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Adquira seu livro - UMA DIETA ALÉM DA MODA: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (também na versão Kindle)"Dance of the Sugar Plum Fairy"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://creativecommons.org/licenses/by/3.0/⁠

Have you ever said "Nothing tastes as good as skinny feels"? If you were around in the 80's and 90's, you likely either said this or have heard it before, thanks to some notorious fad diet programs out there. This week we are discussing the "Skinny Tok" trend that is coming back full circle and bringing with it all of the diet culture sayings and trends that we are working so hard to leave behind. There is a harmful narrative and focus in social media about being skinny again and its hard to ignore the correlation between this type of messaging and the popularity of weight loss drugs.We also rant and rave about peptide supplements and MLM companies trying to capitalize on GLP-1 drugs like Wegovy, Semaglutide, Terzepetide, and more - further proving that diet culture and the supplement industry won't rest until they squeeze every last penny out of you.Buckle up and tune in because we've got some things to say!Subscribe, stack, and save with Cured Nutrition! Never run out of your supply of Serenity or Flow gummies by subscribing and receive 20% off! In addition to that, you can stack your favorite bundle (we love the Harmony bundle!) to receive an additional 10% off. ⁠⁠Click here⁠⁠ for huge savings and don't forget to add our code 'CTC' for additional savings! Thank you Cured Nutrition for sponsoring this episode!Right now you can become an annual member of our Patreon and receive 30% off! Join now for monthly workouts, challenges, recipes, and to become part of the Cut The Crap Community! https://www.patreon.com/cutthecrappodcast⁠⁠⁠Visit our website to learn more about us, contact us, inquire about collaborating with us and more: ⁠⁠⁠https://www.cutthecrappod.com/⁠⁠⁠Follow us on Instagram: @cutthecrapwithbethandmattLike this episode? Why not share it with a friend!Send us a DM on Instagram to let us know what you think of this one, and with episode ideas! If we use your comment or suggestion, we'll give you a shoutout on the podcast!

A new epinephrine nasal spray dosage has been approved for pediatrics; FDA agree to review Semaglutide for weight management; A wearable defibrillator is cleared to prevent sudden cardiac arrest; a low dose formulation of chlorthalidone is approved to treat hypertension; and Selarsdi is now interchangeable with Stelara.

Summary In this episode of the Future of Dermatology Podcast, Dr. Faranak Kamangar discusses the evolving landscape of dermatology with a focus on incretin medications, particularly GLP-1 agonists. This podcast explores the historical context of these medications, their role in weight management, and the implications for dermatological health. Dr. Kamangar addresses the side effects associated with these treatments, including the phenomenon known as 'Ozempic face,' and offers recommendations for maintaining healthy weight and skin health. Takeaways - Incretin medications include GLP-1 agonists and GIPs. - GLP-1 agonists have been used since 2005 for diabetes. - Weight loss medications can have significant side effects. - Rapid weight loss can lead to 'Ozempic face' due to fat loss. - Maintaining muscle mass is crucial during weight loss. - Long-term use of weight loss medications may be necessary. - Lifestyle changes are essential for sustainable weight management. - Dermatologists should be aware of the metabolic effects of these medications. - Natural fat in the face is important for youthful appearance. - Body contouring devices can help target specific fat areas. Chapters 00:00 - Introduction to Dermatometabolic Series 02:47 - Understanding Incretin Medications 06:02 - The Role of GLP-1 Agonists in Weight Management 09:10 - Exploring Side Effects and Safety Profiles 12:08 - Comparative Effectiveness of Semaglutide and Terzepatide 14:48 - Ozempic Face: Causes and Solutions 21:07 - Recommendations for Healthy Weight Management

3rd Place At Detroit Pro next to Wesley Vissers and Matt Greggo, Olympian Classic IFBB Pro Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com

TakeawaysMASH is a significant obesity-related complication.Semaglutide shows promise in treating MASH.Weight loss is crucial for improving liver health.Bariatric surgery remains the most effective treatment.The Essence trial indicates a 63% resolution of NASH.New medications are being developed for obesity treatment.Early intervention is key to preventing severe liver damage.Accessibility of medications is a major concern.Comparative studies are essential for evaluating new treatments.Future treatments may include innovative delivery methods.Chapters00:00 Introduction to MASH and Semaglutide Study04:29 Understanding Metabolic Dysfunction and Its Implications08:02 Essence Trial: Semaglutide's Impact on MASH12:58 Comparative Analysis of New Treatments for MASH17:30 The Future of Obesity Treatment and Drug AccessibilityJoin Vineyard - Dr. Spencer's online clinicSee the study

In this episode, Chris Tew shares his journey with multiple myeloma after being diagnosed on his 69th birthday in 2021.Key Points:Despite extensive standard treatments, Chris's cancer marker plateaued at 0.24 while side effects damaged his heart and threatened his vision.His alternative protocol: Fenbendazole (220mg) and ivermectin (36mg) five days weekly, taken with butter for better absorption.Within two weeks, his cancer marker became undetectable.Chris explains how his 45 years in medical technology gave him the confidence to make an "asymmetric bet"—a calculated health decision with potentially high upside and minimal downside. While maintaining deep respect for his medical team, he shares how cancer unexpectedly became his teacher, bringing him patience, compassion, and a profound sense of gratitude that transformed his outlook on life.This episode is brought to you by FierceHealth.com My wife and I have been microdosing Semaglutide through Fierce as part of our ​Cancer Protocol​ for the past 6 months.Use code PODCAST for 10% off. This interview is part of the reason why we are building CancerCrew.com, a private community for those navigating cancer—whether you're the one diagnosed or supporting your loved one. Click to join the waitlist now.

Join Dr. Gary Pepper, noted endocrinologist as he explains the need for nutrient dense meals during weight loss and introduces you to the new, completely free high protein meal planner which can be found at semagludiet.com. Topics included in this episode:

Rinvoq approved for giant cell arteritis; telehealth companies collaborate with Novo Nordisk for Wegovy access; epidermolysis bullosa wound healing treatment approved; Imaavy approved for gMG; New nasal powder approved for migraine treatment.

腸泌素藥物如 Semaglutide、Tirzepatide 可以絕佳地控制血糖，更有驚人的減重效果，推出後風靡全球，有長達三年的時間被美國 FDA 認定為供不應求。除了糖尿病、減重效果之外，這些腸泌素藥物亦對大量重要疾病有潛在的治療效果（尚待臨床試驗證實），堪稱當代神藥。Tirzepatide 供應商禮來 (Eli Lilly) 因此躍升世界市值最高藥廠，諾和諾德 (Novo Nordisk) 也因 Semaglutide 一度成為歐洲最有價值的公司。 本集節目邀請到新陳代謝科醫師黃峻偉醫師，他同時是專欄《糖尿病筆記》作者。黃醫師與我們介紹糖尿病藥物、腸泌素的歷史延革，講解為什麼腸泌素藥物能有絕佳的減重表現，也討論這些藥物的巨大影響力。  

Semaglutide 2.4 mg weekly led to significant resolution of MASH and reduction in fibrosis after 72 weeks

U.S. economy shrinks. Semaglutide, the main ingredient in diabetes and weight loss drugs Wegovy and Ozempic, may also reverse the signs of liver disease by reducing inflammation and scarring. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Send us a textSusan Colonna is a retired Registered Nurse, having received her Bachelor of Science degree in Nursing from Texas Woman's University in 1992. She has been passionate about natural health remedies and regular exercise for her entire life.In her 40's, Susan was a sponsored athlete and a national-level competitive bikini level bodybuilder and achieved a high level of success by taking 2nd place at the North American NPC National finals in 2014. She is the mother of 4 adult kids and is a grandmother of 2.In January of 2023 Susan was diagnosed with type one diabetes, and she witnessed firsthand how the medical system completely failed her. Today, Susan is enthusiastic about sharing her story about how medical doctors refused to give her insulin, which is insane, but instead would give Ozempic to her, which led her to experience shock, pancreatitis, and eventually a near-death experience.Today she is extremely outspoken about the benefits of the carnivore diet, and she encourages others to be their own health advocates.Find Susan at-TW- @truthhhseekerFB- @Susan Parker Colonnahttps://yandex.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

¿Ozempic es solo para bajar de peso? La respuesta es mucho más profunda. En este video te explico, con evidencia científica clara, lo que realmente sucede en tu cuerpo cuando tomas Ozempic (semaglutida): -Cómo regula el apetito en tu cerebro -Cómo mejora tu digestión y metabolismo -Por qué reduce el "ruido de comida" -Y cómo puede devolverte el control sobre tu salud metabólica ¡Suscríbete a este podcast en tu plataforma favorita para no perderte nada!

In this episode, we sit down with Dr. Johnny Franco live at the Aesthetic Meet 2025 in Austin, Texas. Dr. Franco shares insights from the frontlines of the "Ozempification" of aesthetics, how weight loss journeys are reshaping demand for both non-surgical treatments and advanced body contouring, and why the next wave of cosmetic surgery is already here. We also dive into how AI is beginning to transform aesthetic practices, and what the future holds for regenerative medicine, body sculpting, and patient care over the next few years. A fast-paced, forward-looking conversation you won't want to miss.Get a Free Website Analysis: https://www.influxmarketing.com/Instagram: https://www.instagram.com/influxmarketing/Twitter: https://twitter.com/influxmarketingLinkedIn: https://www.linkedin.com/company/influx-marketing-co

It seems like we all have patients taking Semaglutide or Tirzepatide and in this episode Tom Viola breaks down the things we need to know. How does it act? What should we be on the look our for? What oral/systemic manifestations might there be? Be sure to give this short episode a listen! Resources: Be sure to reach out to him if you have any questions by emailing TomViola@tomviola.com, visit his website TomViola.com or check out his social media - @pharmacologydeclassified

How digestive health can ruin your physique & quality of life w/ Austin StoutJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Start of Gut Health02:20 Protein Digestion and Overeating05:10 High DHT Doses in Bodybuilding08:00 Genetics and Drug Dosages11:30 Social Media vs Real Life Knowledge14:00 Bodybuilders Eating Too Much Protein?18:00 Digestion Issues from High Protein22:00 Nutrient Deficiencies in Bodybuilding26:00 Magnesium Deficiency Explained30:00 Bloodwork Tips: Alkaline Phosphatase34:30 Anemia, Iron, and Lactoferrin39:00 How to Fix Low Iron Safely43:00 Electrolytes and Muscle Function46:30 Adrenal Fatigue and Cortisol Levels50:00 Adrenal Health and Blood Markers53:00 How to Recover from Burnout57:00 Managing Allostatic Load01:00:00 Psychological Stress and Training01:01:53 Stress & Mindset in Bodybuilding01:07:58 GLP-1 Peptides & Weight Loss01:15:24 Obesity & Hunger Hormones01:26:39 Autoimmune & Gut Health01:33:46 Fruits, Veggies & Digestion01:43:11 Insulin & Growth in Women01:50:20 Metabolic Damage & Prep Struggles01:54:28 Longevity in Bodybuilding01:56:22 Final Thoughts & Sign-Off

When it comes to pharmacy benefits, no topics make headlines like GLP-1s and weight loss programs. On this episode of HR Benecast,  Dr. Lia Rodriguez and Erin Bacon from CVS Health share what makes a clinical weight loss program really work. Listen to hear the latest obesity stats, obesity's link to other chronic conditions, the importance of lifestyle changes and more. 

It seems like we all have patients taking Semaglutide or Tirzepatide and in this episode Tom Viola breaks down the things we need to know. How does it act? What should we be on the look our for? What oral/systemic manifestations might there be? Be sure to give this short episode a listen! Resources: Be sure to reach out to him if you have any questions by emailing TomViola@tomviola.com, visit his website TomViola.com or check out his social media - @pharmacologydeclassified

In this first part of a two-part series, Dr. Saluja and Kane unpack how GLP-1 and GIP medications, including Ozempic, Wegovy, and Mounjaro, are reshaping not just metabolism, but also facial structure, leading to what's now known as "Ozempic Face." In this episode, they explore what GLP-1 receptor agonists and GIP agonists are, how rapid fat loss affects skin, collagen, and volume, and introduce key strategies that can be done at home from a nutritional perspective to support collagen health and overall facial balance. Join them as they break down the science and lay the foundation for more advanced treatment approaches discussed in Part Two. Thank you for your listenership!

Semaglutide has become the weight management sensation of the decade, but what's the science behind the hype? In this episode, I break down how these GLP-1 agonists really work, why 85% of patients regain weight after stopping, and why I use them as just one tool in my comprehensive approach to metabolic health. From side effects to proper patient selection, get the unfiltered medical perspective you need before considering these medications. Episode Highlights: The meteoric rise of Ozempic, Wegovy and Rybelsus that's causing nationwide shortages How semaglutide actually works in your brain and digestive system to reduce appetite Why patients regain weight after stopping and the importance of lifestyle integration Real talk about side effects - from common digestive issues to rarer complications The critical shift needed in how medicine approaches obesity treatment Important differences between FDA-approved formulations and compounded alternatives My professional recommendations for patient selection and monitoring protocols How H.E.R. University supports comprehensive metabolic health beyond medication Episode Resources: Dr. Shawn Tassone's Practice | https://www.drshawntassone.com Dr. Shawn Tassone's Book | The Hormone Balance Bible Dr. Shawn Tassone's Integrative Hormonal Mapping System | Hormone Archetype Quiz Thank you to our sponsor, Endurance Products Company! After over 25 years of practicing medicine, I'll be the first to tell you that not all supplements are created equal. But when I discovered Dihydroberberine SR, by Endurance Products Company, I was genuinely impressed.  It's highly bioavailable and outperforms standard berberine at significantly lower doses. You can explore their offerings at endur.com. Not only is the science solid, but I love that Endurance Products Company is a family-run American company that has cared about doing things right since 1978. I've started recommending Dihydroberberine to my patients who struggle with blood sugar management, and the results speak for themselves. So much so, that I personally take this supplement for helping to support healthy blood sugar levels, heart health, and tap into how my body uses fats for energy As a special offer for my audience, Endurance Products Company is providing a 10% discount on your order! Simply use the code DRT10 at checkout when you visit endur.com. Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.

**Dr. Lisa Faast shares an important update on the current status of Semaglutide Compounding as of April 23** **Show Notes:** 1. **Semaglutide Compounding Update for 503A Pharmacies** [0:00] 2. **Tirzepatide Compounding and Legal Considerations** [3:38] 3. **Practical Advice for Pharmacies** [6:36] 4. **Final Thoughts and Contact Information** [7:39] **Links mentioned in this episode:** [FDA's decision on Semaglutide] (https://www.fda.gov/drugs/drug-safety-and-availability/fda-clarifies-policies-compounders-national-glp-1-supply-begins-stabilize) [OFA-Outsourcing Facilities Association] (https://www.503bs.org/) Websites Mentioned: https://www.olympiapharmacy.com/ https://www.drlisafaast.com/ ----- #### **Becoming a Badass Pharmacy Owner Podcast is a Proud to be Apart of the Pharmacy Podcast Network**

So, you've heard the rumors—“GLP-1s destroy your muscle!” But… is that actually true? Think again. Today, we're setting the record straight. If you're serious about real, healthy weight loss—and actually keeping your strength for the long haul—this episode is a must. We're diving into a long-overdue conversation about GLP-1 medications, metabolism, body composition, and what's really happening to your muscle mass on these meds. Because weight loss isn't just about the scale—it's about how you lose it. Let's get into it. Quick Basics — What Are GLP-1 and GIP/GLP-1 Medications? Let's start at ground zero. GLP-1 medications — like semaglutide (Wegovy and Ozempic) — are game-changers for weight loss and diabetes. They work by mimicking gut hormones that regulate appetite, blood sugar, and insulin release. GLP-1 (glucagon-like peptide 1) slows down how fast your stomach empties, helps your body respond better to insulin, and most importantly — makes you feel fuller, longer. Tirzepatide (Mounjaro and Zepbound), also hits GIP receptors — that's glucose-dependent insulinotropic polypeptide — lending to more blood sugar regulation in some people. What Happens to Your Body During Weight Loss? No matter how you lose weight — whether it's from keto, bariatric surgery, or GLP-1 meds — your body isn't just burning fat. It's normal to lose a mix of fat mass and lean mass, which includes muscle, bone, and organ tissue. But the goal with any good weight loss plan is to maximize fat loss and minimize muscle loss. The Myth: “GLP-1s Make You Lose All Your Muscle” Here's the truth: GLP-1 medications do NOT inherently destroy your muscle mass. In fact, clinical studies have shown that GLP-1 medications, like semaglutide, have osteoblastic effects, meaning they can stimulate the activity of osteoblasts, the cells responsible for bone formation. This can potentially help improve bone density and support bone health. While the primary role of GLP-1 medications is to aid in weight loss and improve blood sugar control, these osteoblastic effects may offer additional benefits, especially in individuals at risk for osteoporosis or bone loss. If you see muscle loss during GLP-1 therapy, it's because of rapid overall weight loss and a lack of resistance training and protein — not because the medication is wasting your muscle. It's the same thing we see in ANY rapid weight loss — if you don't stimulate your muscles and feed them the right building blocks, your body gets rid of them because it thinks you don't need them. Muscle is metabolically expensive. Your body is smart — if it thinks you're not using muscle, it's going to save energy and dump it. That's biology — not the medication. Why Protein and Resistance Training Are Non-Negotiable If you're on a GLP-1, your appetite is lower — which is great for fat loss, but it means you could accidentally under-eat protein if you're not paying attention. Protein is literally the raw material your body uses to maintain and build muscle. Protein also helps build and repair tissues and is essential for producing enzymes, hormones, and maintaining a healthy immune system. Without enough, your body will start to break down lean tissue to make up the difference. And without resistance training (e.g., bodyweight exercises), your body assumes you don't need the muscle anymore. Use it or lose it. How to Protect (and Even Build) Muscle on GLP-1s Here's the simple formula: Prioritize protein: Aim for at least 0.8 to 1 grams per pound of body weight per day. Some need even more during active fat loss. Strength train 2–4 times a week: Focus on compound movements — think squats, deadlifts, presses, pulls, push ups, lunges, planks, and wall sits. Don't fear the scale: Remember that as you lose fat and build muscle, the number might not drop as fast — but your body composition is improving (e.g., reduced body fat, more defined muscles, improved waist circumference, increased energy and strength, and don't forget improved cardiovascular health). Think long-term: It's not just about losing weight — it's about keeping a strong, healthy, metabolically active body. THIS is what helps maintain weight loss. Making sustainable lifestyle changes can be challenging, but they are the most important choice you can make when it comes to losing weight and improving your metabolism in the long run. The goal isn't just weight loss — it's fat loss while preserving and strengthening lean mass. It's important to remember that GLP-1s are a powerful tool, but they aren't a magic. You still have to partner with your body — feed it well, move it wisely, and respect the incredible machine it is. Strong, lean, metabolically active — that's the future we're building, not just smaller bodies. Thanks again for listening to The Peptide Podcast. If this episode helped you rethink your game plan, do me a favor — share it with someone who's starting their GLP-1 journey. And as always, have a happy healthy week! Thanks for listening to The Peptide Podcast. If you found this episode helpful, please follow or leave a review. And if there's a topic you'd like to hear more about, feel free to reach out—we'd love to hear from you. As always, have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey.  Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

WAYS TO SUPPORT MY WORK ⬇️

“The Martian”  the current 4th place at Mr. Olympia and Prague Pro Champion. One of the youngest stars in open bodybuilding. Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro & Bodybuilding Journey  00:00:27 Training & Recovery Secrets  00:01:06 PEDs & Gear Talk  00:02:13 Honest Message on PEDs  00:03:59 Staying Healthy as a Pro  00:08:07 Diet & Digestion Struggles  00:12:11 Training Like a Beast  00:18:58 Genetics & Recovery  00:31:25 From Pharmacy to Bodybuilding  00:54:10 Sleep & CPAP Life  00:57:46 Supplement & Health Protocols  00:59:18 Melatonin: Super Antioxidant?  01:01:00 Gut Health & Digestion  01:02:55 T3 vs. T4: Thyroid Secrets  01:10:34 Steroid Side Effects & Lessons  01:14:24 Why Orals Aren't Worth It  01:17:33 Rest & Recovery Hacks  01:20:14 Sleep = Skeleton Face?  01:23:27 Confidence & Olympia Mindset  01:25:39 Downsides of Fame  01:28:50 Social Media & Business  01:31:51 Bob vs. Nick Drama  01:34:39 Pittsburgh Pro Goals  01:53:23 Worst Cycle Experience  02:00:47 Stress-Free Gains  02:14:38 Chris Bumstead Rivalry  02:23:18 Weed & Bodybuilding  02:31:31 Villain to Fan Favorite  02:37:04 Final Message

Ozempic, Mounjaro, Semaglutide, Retatrutide, and other GLP-1 agonist drugs are becoming more popular in bodybuilding.  In today's podcast I discuss why, the pros and cons of these drugs, and how to mitigate the negative impacts.

Dr. Todd Cevene is a leader in integrated healthcare and natural weight loss, with 25+ years of experience. Creator of the Metabolic Optimization System, he has helped 75,000+ individuals lose over 2 million pounds naturally. Dr. Cevene is a speaker and consultant and has addressed audiences of up to 5,000. Author of Business Management for Physicians, he specializes in metabolic restoration and private healthcare consulting.https://www.seniorcareauthority.com/resources/boomers-today/

In episode 58 we discuss a randomized controlled trial of semaglutide for alcohol use disorder.    Hendershot CS, Bremmer MP, Paladino MB, Kostantinis G, Gilmore TA, Sullivan NR, Tow AC, Dermody SS, Prince MA, Jordan R, McKee SA, Fletcher PJ, Claus ED, Klein KR. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789.     We also discuss benzodiazepine tapering guidelines and new ways to use Sublocade.    ASAM Clinical Practice Guideline on Benzodiazepine Tapering  Sublocade label changes  ---  This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.  CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  ---  Original theme music: composed and performed by Benjamin Kennedy  Audio editing: Michael Bonanno  Executive producer: Dr. Patrick Beeman  A podcast from Ars Longa Media  ---   This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.   The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.  Email: addictionmedicinejournalclub@gmail.com   Facebook: @AddictionMedJC  Facebook Group: Addiction Medicine Journal Club  Instagram: @AddictionMedJC   Threads: @AddictionMedJC  YouTube: addictionmedicinejournalclub   Twitter/X: @AddictionMedJC   Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro02:00 Genetics & Steroid Response06:10 Building a Family While Competing09:45 Health After Bodybuilding13:00 The Reality of TRT After Pro Life17:00 Testosterone and Brain Chemistry21:00 How to Survive the Health Phase25:00 Bloodwork Isn't Everything30:00 Estrogen: More Than a Number35:00 Glutathione & Antioxidants40:00 Liposomal Supplements Are OP44:00 Genetic Testing for Bodybuilders49:00 Personalized Medicine is the Future54:00 Fast vs Slow Steroid Metabolizers58:00 Drug Dosage ≠ Death Risk01:02:00 The Oral Steroid Blind Spot01:04:30 When Should You Start PEDs?01:10:00 A Warning for the Younger Guys01:13:00 What's the Right Age to Begin?01:16:00 Final Thoughts01:32:23 Sleep Troubles & Insomnia Hacks01:35:00 Biochemistry of Falling Asleep01:38:00 Dopamine, Serotonin & Brain Dumping

In this episode, Rick speaks with Alloy COO Suzanne Robb about whether weight loss shots are a friend or foe of the fitness industry.Suzanne revisits her experience with GLP-1 weight loss medications - semaglutide and tirzepatide. She offers a unique perspective on how medical intervention doesn't have to conflict with a fitness-first lifestyle.Suzanne also opens up about her struggles with weight loss in her 60s despite years of working out and healthy eating. When traditional methods failed, she turned to GLP-1s and found success, losing 30 pounds and regaining control of her health.She details her journey, the pros and cons of different medications, and how strength training preserved her muscle mass.Rick and Suzanne explain how Alloy's strength-based approach makes it the perfect companion to these medications. They bust myths, challenge fitness dogma, and offer a hopeful message for those feeling stuck.Listen in to learn more about how to align your fitness business with medical wellness.Key TakeawaysIntro (00:00)Semaglutide and tirzepatide as weight loss aids (02:25)Weight loss results and side effects after 3 months (09:05)Transition to maintenance dosing (12:02)Criticism from fitness purists (14:23)Benefits of GLP-1s beyond just weight loss (16:27)Strength training's role in preventing muscle loss (20:08)GLP-1s shift calorie focus from burning to managing intake (24:03)Alloy and GLP-1s are not competitors - they're allies (30:42)Additional Resources:- Alloy Personal Training- Learn About The Alloy Franchise Opportunity---------You can find the podcast on Apple, Google, Spotify, Stitcher, or wherever you listen to podcasts.If you haven't already, please rate and review the podcast on Apple Podcasts!

In this month's Digital Health Download, Steve, Halle, and Michael take a deliberately optimistic look at key headlines in healthcare technology. From the impressive impact of AI scribing tools on physician satisfaction to encouraging survival rates among digital health unicorns from the ZIRP-era, the hosts highlights bright spots in an often challenging industry.We cover:

Svein Falzon @genet1cAnomaly, from world's biggest 20 year old to now 2 years later… Just because we see an online persona, doesn't mean we know who someone may really be in person. While meme'd the biggest 20 year old by Larry Wheels and others… Whatever it was that got him to use ped's, with others realizing his potential before hand and with absolutely nothing to lose, committing his everything to this path seems the only light at the end of the tunnel to make enough money to get his mom and himself out of this hell hole and achieve his dreams at the same time.Watch it: https://www.youtube.com/watch?v=lR7YRb0DBhIJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro02:10 - The Masked Bodybuilder Origin Story07:04 - Social Media & Fitness Industry Growth12:01 - Training & Physique Development18:40 - Back & Hamstring Growth Struggles22:32 - Squat Form & Hip Mobility Issues31:22 - From 100K to 1.5M Followers34:35 - The Mindset of Never Being Enough40:07 - Health, Steroids, and Responsible Use45:55 - Growing Up Poor & Family Motivations50:16 - Sam Sulek's Pro Card & Modern Bodybuilding56:10 - Fake Beefs for Engagement1:02:11 - Competing in Bodybuilding: Future Plans1:04:20 - Acne, Blood Pressure & Health Protocols1:11:07 - Ultimate Life Goals1:12:00 - Svein's Mom and Why He Continues Bodybuilding1:15:12 - Finding the Right Coach1:20:18 - Favorite Steroids & Offseason Compounds1:25:02 - The Truth About the Togi Beef1:27:12 - Gear selection1:28:27 - Svein's Final Message#podcast #mentalhealth #humanoptimization #holistic #health #hrt #connection #story #discipline #fitness #ifbbpro #npc #bodybuilder #bodybuilding #selfimprovement #workout #gym #nutrition #mensphysique #classicphysique #love #discipline #relationships #tren #workout #gym #trt #hormones #discipline #gear #steroids #bodybuilding #peptides fitness trt hormones workout gear trensparent

Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)Struggling to find compounded versions of Semaglutide and Tirzepatide? You're not alone. As these medications become harder to access, many patients are left wondering, "What's next?"In this episode, we sit down with Joe Zucchi, a physician assistant, personal trainer, and clinical supervisor at Transition Medical Weight Loss in Salem, New Hampshire. Joe walks us through the current shortage of compounded medications, what's really going on behind the scenes, and why safe, FDA-approved alternatives are more important than ever. But it's not just about medication. We dive into why obesity isn't just about willpower, discussing how it's a complex issue that goes beyond simple behavior choices. Joe also sheds light on the issue with compounded GLP-1 medications and the risks involved. Plus, he shares practical tips on how to make exercise work for you, whether you're just getting started or looking to refine your routine.Joe's approach to weight management is unique, combining fitness, nutrition, medical treatments, and even an on-site marketplace stocked with healthy, portion-controlled foods. His clinic's well-rounded approach ensures that patients receive the support they need for long-term success, no matter where they are on their weight management journey.Tune in to hear Joe's expert insights and find out how to stay on track with your goals. Don't forget to listen to the full episode!Connect with Mr. Zucchi:Linkedin: Joseph Zucchi, PA-CX: JPZfitness Instagram: transitionweightlossConnect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com

In this Ask Me Anything episode of The Art of Being Well, Dr. Will Cole and his telehealth team answer listener questions on the hottest health topics. They dive into the rise of POTS cases, the surprising link between ADHD and longevity, and how semaglutide may help reduce addictive behaviors. They also break down the latest research on antidepressants and cognitive decline, discuss RFK's stance on vaccines, and explore the deeper issues behind corporate capture and the food crisis. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Studies Mentioned in This Episode: SSRI Use & Cognitive Decline: BMC Medicine StudyADHD & Life Expectancy: The British Journal of Psychiatry StudySemaglutide & Alcohol Cravings: JAMA Psychiatry StudyPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:AG1 is offering new subscribers a FREE $76 gift when you sign up. You'll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. So make sure to check out DrinkAG1.com/willcole to get this offer!Listeners of The Art of Being Well can claim an exclusive three-month free trial, with no credit card required at www.YNAB.com/willcole.Go to Quince.com/willcole for 365-day returns, plus free shipping on your order!Get started at FACTORMEALS.com/FACTORPODCAST and use code FACTORPODCAST to get 50% off your first box plus free shipping. Pique is offering 20% off plus a FREE rechargeable frother and glass beaker with my exclusive link: Piquelife.com/WillCole.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.