Podcasts about semaglutide

Peripheral artery disease has been called the ‘silent circulatory crisis'—affecting millions, limiting mobility, and quietly raising the risk of heart attack, stroke, and limb loss. For decades, treatment focused on walking programs, aspirin, and sometimes a stent or bypass. But today, the landscape is changing. From PCSK9 inhibitors that drive cholesterol to record lows, to GLP-1 agonists like semaglutide improving walking distance, to novel antithrombotic strategies that balance bleeding and clotting—PAD care is entering a new era. In this episode, we'll explore the breakthroughs, the evidence behind them, and what they mean for patients who just want to keep moving forward." Hosted by the University of Michigan Department of Vascular Surgery: - Robert Beaulieu, Program Director - Frank Davis, Assistant Professor of Surgery - Luciano Delbono, PGY-5 House Officer - Andrew Huang, PGY-4 House Officer - Carolyn Judge, PGY-2 House Officer Learning objectives:  1.  Describe the current evidence-based recommendations for multifactorial medical management of peripheral artery disease (PAD), including lipid, glycemic, and antithrombotic strategies per 2024 SVS/AHA guidelines.  2. Interpret the clinical implications of the FOURIER trial regarding the role of PCSK9 inhibition in reducing cardiovascular events in patients with atherosclerotic disease, including PAD.  3.  Evaluate the emerging role of GLP-1 receptor agonists, such as semaglutide, in improving walking performance and quality of life among patients with diabetic PAD based on findings from the STRIDE trial. Sponsor URL: https://www.goremedical.com/ References:  H. L. Gornik et al., “2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease,” JACC, vol. 83, no. 24, pp. 2497–2604, June 2024, doi: 10.1016/j.jacc.2024.02.013. L. Mazzolai et al., “2024 ESC Guidelines for the management of peripheral arterial and aortic diseases: Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), and the European Society of Vascular Medicine (ESVM),” Eur Heart J, vol. 45, no. 36, pp. 3538–3700, Sept. 2024, doi: 10.1093/eurheartj/ehae179. https://pubmed.ncbi.nlm.nih.gov/40169145/ M. S. Sabatine et al., “Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease,” N Engl J Med, vol. 376, no. 18, pp. 1713–1722, May 2017, doi: 10.1056/NEJMoa1615664. https://pubmed.ncbi.nlm.nih.gov/28304224/ M. P. Bonaca et al., “Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial,” Lancet, vol. 405, no. 10489, pp. 1580–1593, May 2025, doi: 10.1016/S0140-6736(25)00509-4. https://pubmed.ncbi.nlm.nih.gov/40169145/ N. E. Hubbard, D. Lim, and K. L. Erickson, “Beef tallow increases the potency of conjugated linoleic acid in the reduction of mouse mammary tumor metastasis,” J Nutr, vol. 136, no. 1, pp. 88–93, Jan. 2006, doi: 10.1093/jn/136.1.88. https://pubmed.ncbi.nlm.nih.gov/16365064/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:01:26 Holidays & Work00:02:14 Vegas vs. California: The "Realness" Factor00:03:00 The Secret to 23-Inch Arms00:04:57 Genetics: Korean Calves & Ethnic Muscle Insertions00:06:30 The New Generation of Bodybuilders00:08:27 The Boston Lloyd Controversy: Truth vs. Harm00:13:11 Debunking the "10 Grams of Gear" Myth00:14:53 Natural Bodybuilding & Social Media Expectations00:16:47 The Limitless Mindset00:18:52 Evan's Origin Story: From Obese to Anorexic00:20:39 The "Perma-Cut" Trap: Fear of Eating00:22:46 Drugs Are Tools, Not the Foundation00:25:42 Losing Gains to Stay Lean (The Teenage Mistake)00:28:03 Winning the First Show & Turning Pro00:28:27 Starting PEDs at Age 19 (500mg Test)00:30:51 First Cycle Results & The "Cold Turkey" PCT00:32:45 Coming Off Gear: Bloodwork Reality Check00:34:28 Rebound Strategies: Staying On vs. PCT00:36:58 Testing TRT Levels & Fertility00:39:53 Host Message: Subscribe & Sponsors00:41:03 First Growth Hormone Experience (Serostim)00:41:50 The Holy Trinity: Test, Tren, & Winstrol00:44:12 Injectable Winstrol: Alpha Pharma Rexogin00:46:26 Oral Winstrol Side Effects: Gut Health & Acne00:49:02 Quitting Orals (Reflux Issues)00:51:55 Modern Coaching Lunacy: High Dose Orals00:53:26 Acute Toxicity: Why Injectables are Safer00:58:09 Finding "Real" Injectable Winstrol 101:00:55 GH Strategies: Prep vs. Off-Season01:02:13 Insulin Without GH? The Joe Palacios Anomaly01:03:11 Is Growth Hormone Overrated?01:04:26 Cycling GH: 2 Days On, 1 Day Off01:05:21 The Ronnie Coleman Standard01:06:09 The GH15 Era & Internet Rumors01:09:42 The "One Bottle of Sustanon" Pre-Stage Protocol01:13:28 GH Frequency Debate01:16:19 What Pros Actually Take: The 4-6 IU Reality01:19:02 Steroids in Japan01:20:41 Earning the Pro Card01:21:10 2009 NY Pro Win & The Oscar Ardon Era01:23:58 Passion vs. Career: The Bodybuilder's Dilemma01:28:44 Evan's Heaviest Cycle: 1,500mg Test & Suspension01:30:55 The Cytadren (Aminoglutethimide) Nightmare 201:32:43 Diuretics & Dangerous Prep Protocols01:34:26 Insulin Frequency & Diabetes Risk01:37:53 Dangerous Modern Coaching: 100mg Orals Daily01:40:15 Longevity & The "One Vice" Rule01:43:45 Essentiale Forte: The Ultimate Liver Supplement 301:45:33 Host Message: Transcend HRT01:46:20 Training Philosophy: Oscar Ardon's "Mental Torture" 401:50:38 Science-Based Op

If you're on a GLP-1 fat loss journey and something feels off — stalled fat loss, extreme fatigue, nausea, food aversions, or muscle loss — this episode is for you.   Nearly 15% of the U.S. population is now on a GLP-1, yet by research, over 90% are making the same mistake: choosing weekly semaglutide over daily liraglutide without understanding how human behavior, metabolism, and muscle retention actually work.   In this episode, I break down:   ● Why humans always choose the path of least resistance (and why doctors prescribe weekly shots) ● The real difference between semaglutide vs. liraglutide ● Why weekly dosing causes more nausea, fatigue, food aversion, and training drop-off ● How semaglutide increases risk of lean muscle loss and metabolic slowdown ● Why daily liraglutide provides smoother appetite and glucose control ● How half-life impacts hunger, energy, and adherence ● Why extreme appetite suppression backfires long-term ● How GLP-1s should be used to support training and protein intake — not replace them   GLP-1s are powerful tools — but when used incorrectly, they create the exact rebound weight gain, metabolic damage, and frustration women are trying to avoid.   If you want my full GLP-1 Micro-Dosing Blueprint — including injection schedules, best practices, workouts, and nutrition:  

Welcome back to driving with Natalie! I decided it was too much fun to chat with you all in between the day to day so instead of posting a vault episode, let's hang out in my car again. So, my family and I got into some difficult conversations after the World Cup, Piper is now climbing out of her crib, and I am happy to share I am seeing some results from my semaglutide trial! Sponsor note: Go to ⁠Airdoctorpro.com⁠ and use promo code HUNGRY to get up to $300 off today.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Placing 2nd at Texas Pro. Real talk the whole time, everything you'd want to know, from the deep sht to how they blew up and the juicy deets in between. Honored to know these bros. The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00Intro 00:02:21The Post-Show Dopamine Crash vs. Prep "Grumpiness"00:02:42Relationship Survival Guide: "The Pre-Emptive Apology"00:04:31Reading Cortisol: Why "Low" Can Be Worse Than "High"00:05:12Adrenal Burnout Protocol: "Baby Sessions" & No Cardio00:06:52Elliot's Pro Debut: Navigating the "Growing Pains"00:07:29The "Food Noise" Reality: When One Donut Turns into Four00:08:03Retatrutide ("Retta"): The 2mg Protocol for Appetite Control00:09:19Flashback: The Misery of the 1100-Calorie Natty Prep00:12:14The Cult Following of the Unranked Podcast00:14:41The Origin Story of the "Unranked" Name00:16:19The Great Debate: Health Phase vs. Aggressive Rebound00:18:43The Burnout Checklist: When to Abort the Rebound00:20:10Metabolic Adaptation: When the Body Stops Responding00:23:29Methylation Hacks: Methyl Folate & The MTHFR Mutation00:25:31The "Mic Check" Comedy Segment00:28:05Andrew's Origin: The Magazine Era (1996)00:33:58Kyle's Origin: The Mentorship Era (2014)00:37:54Joining the "Dark Side" at Age 10? (Andrew's Story)00:39:57Andrew's First Cycle: The "Tren & D-Bol" Kitchen Sink00:42:00Kyle's First Cycle: Pro-Hormones & Peer Pressure00:43:19The "Mad Scientist": Snorting Andro at Age 1400:45:10The Golden Rule: Wait Until 25 (Or 30)00:47:09The "Natty Ceiling": Switching to the Dark Side (Chris's Story)00:49:58The Halo-Only Nightmare: A Lesson in Hormonal Crashing00:56:27Financial Advice for Young Pros: Freeze Your Sperm01:03:16Training Mistakes: The "Two-a-Day" Trap01:06:57The Meadows Hack: Binge Until You're Sick01:10:54The "Dreamer Bulk" Mistake: Fat Doesn't Turn to Muscle01:13:00The Secret to Rebounding: Stay "Hungry" & Insulin Sensitive01:21:38Executing the Health Phase: Diet & Training Adjustments01:26:47The "Zero Carb" Depletion Experiment (Martin's Protocol)01:35:19Peak Week Orals: Managing Winstrol & Digestion Issues01:40:52The "Detox Week" Protocol: No Training, Med Diet01:44:11Setting the Cap: Max Weight Gain Post-Show (10-15%)01:49:49The "Soft Landing": Using Primo/Proviron to Bridge01:51:25The "No-Go" List: DNP & Dangerous Diuretics01:

Broadcast from KSQD, Santa Cruz on 12-18-2025: Dr. Dawn opens by examining how market competition is actually working in the weight loss drug sector. Novo Nordisk's Ozempic and Wegovy compete against Eli Lilly's Monjaro and ZepBound, with prices dropping nearly 50% as companies launch direct-to-consumer websites. The main barriers remain needles and refrigeration, driving development of oral versions. Novo's Wegovy pill awaits FDA approval for early 2026 launch at $150 monthly. Next-generation drugs show remarkable results: Eli's retatrutide causes 24% weight loss in 48 weeks, while Novo's Cagrisema combines semaglutide with amylin to reduce muscle loss. Pfizer paid $10 billion for Metsera's once-monthly drug despite significant side effects. A quick fiber tip suggests adding plain psyllium to morning coffee for cardiovascular and microbiome benefits. Start with half a teaspoon and work up to two teaspoons (10 grams) over several weeks to avoid gas. The prebiotic fiber improves glucose tolerance and may reduce cancer risk. UC San Diego scientists discovered why cancers mutate so rapidly despite being eukaryotic cells with protected chromosomes. The answer is chromothripsis, a catastrophic event where the enzyme N4BP2 literally explodes chromosomes into fragments. These reassemble incorrectly, generating dozens to hundreds of mutations simultaneously and creating circular DNA fragments carrying cancer-promoting genes. One in four cancers show evidence of this mechanism, with all osteosarcomas and many brain cancers displaying it. This explains why the most aggressive cancers resist treatment. Research from 2013 shows any glucocorticoid use significantly increases venous thromboembolism risk, with threefold increases during the first month of use. The risk applies to new and recurrent clots, affecting both oral and inhaled steroids, though IV poses highest risk and topical the lowest. Joint injections fall somewhere between inhaled and oral. Anyone with prior blood clots should avoid steroids except for life-threatening situations like severe asthma attacks requiring ventilation. A meta-analysis of 20 randomized controlled trials shows creatine supplementation helps older adults (48-84) maintain muscle mass when combined with weight training two to three times weekly. The supplement provides no benefit without exercise. Recommended dosing starts at 2 grams and works up to 5 grams daily. Vegans benefit most since they consume little meat or fish. Important caveat: creatine throws off standard kidney function tests (creatinine), so users should request cystatin C testing instead for accurate renal health assessment. A new JAMA study suggesting risk-based mammogram screening is fatally flawed. First, researchers offered chemopreventative drugs like tamoxifen only to the high-risk group, contaminating the study design. Second, the demographics skewed heavily toward white college-educated women, missing the reality that Black women face twice the risk of aggressive breast cancer with 40% higher mortality. Third, wild-type humans failed to follow instructions—low-risk women continued getting annual mammograms anyway while high-risk women skipped recommended extra screenings. The conclusion of "non-inferior" outcomes is meaningless given poor adherence. Stick with annual mammograms, and consider alternating with MRIs for high-risk women. The EAT-Lancet report condemns red meat based purely on observational data showing correlations with heart disease, cancer, and mortality. But people who eat lots of red meat differ dramatically from low consumers: they weigh more, smoke more, exercise less, and eat less fiber. Studies can't control for sleep quality, depression, or screen time. Notably, heavy meat eaters also die more in accidents, suggesting a risk-taking lifestyle phenotype. The inflammatory marker TMAO is higher in meat eaters, but starch is also pro-inflammatory. Eating red meat instead of instant ramen might improve health. A balanced diet with limited amounts beats epidemiology-based blanket statements. Dr. Dawn grades Dr. Oz's performance as CMS administrator. Starting at minus one for zero relevant experience, he earns plus two for promoting diet, exercise, and gut health on his show. He studied intensively after nomination, calling all four previous CMS directors repeatedly and surrounding himself with experienced staff (plus one). He finalized Medicare rules favoring prevention over surgery and earned bipartisan praise as "a real scientist, not radical" (plus one). He divested healthcare holdings but kept some blind trust interests (minus 0.5). He's developing a CMS app and partnering with Google on a digital health ecosystem (plus one), but supports ending ACA subsidies that will raise premiums for millions (minus one). He correctly promoted COVID vaccines and contradicted Trump's Tylenol-autism claims (plus one). Final score: 3.5 out of 5 possible points, the only positive score for any Trump health administrator.

Send us a textWelcome back Rounds Table Listeners! In our year-end episode, Drs. Mike and John Fralick discuss five important research studies published in 2025:Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO) (0:00 – 4:20)Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity (SUMMIT) (4:21 – 9:30)Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) (9:31 – 15:03)Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (FRESH-UP) (15:04 – 18:09)Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (ESSENCE) (18:10 – 23:49)The Good Stuff (23:50 – 25:27):Toronto Star Santa Claus Fund, Calgary Food Bank, The War Amps Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Join our scientific team in the discussion of the 3 most clinically impactful papers of the month, the crème de la crème of our weekly top picks.This month we're discussing:#1 - Triple Versus Dual Lipid-Lowering Therapy in Acute Coronary Syndrome: The ES-BempeDACS Randomized Clinical TrialDOI: https://doi.org/10.1093/eurheartj/ehaf724#2 - Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trialDOI: 10.1056/NEJMoa2509688#3 - Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trialDOI: 10.1016/S0140-6736(25)02155-5Scientific team:Ricardo Ladeiras Lopes, Mário Santos and João Sérgio NevesDiscover Medical Portfolio App weekly top picks - the latest and most relevant papers, curated by our team of experts! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://linktr.ee/medicalportfolioapp⁠⁠

This week, we're talking: Going no contact, All Her Fault, the Fanning Sisters, ADHD flow states, JVN's new favorite European city, Miss Universe pregnancy rules, Norway's royal family, Matthew Morrison's dance breaks, thirsty little c*nts on Tiktok, "rebranding" domestic terrorism, Bari Weiss, blocking CBS news, Glogg, Tumeric, and success with semaglutides.  Check out the JVN Patreon for exclusive content, bonus episodes, and more! www.patreon.com/jvn  Follow us on Instagram @gettingbetterwithjvn Jonathan on Instagram @jvn and senior producer Chris @amomentlikechris  New video episodes Getting Better on YouTube every Wednesday.  Senior Producer, Chris McClure Producer, Editor & Engineer is Nathanael McClure Production support from Chad Hall Our theme music is also composed by Nathanael McClure. Curious about bringing your brand to life on the show? Email podcastadsales@sonymusic.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Placing 2nd at Texas Pro. Real talk the whole time, everything you'd want to know, from the deep sht to how they blew up and the juicy deets in between. Honored to know these bros. The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00Intro00:03:43First Cycle Experience00:06:1290s Mentality vs. Modern Science00:08:00Mental Side Effects & Anxiety00:09:22"Death Face" at the 9-to-500:15:51Fat Kid to Anorexia: The Origin Story00:23:51The 80lb Binge Eating Rebound00:26:34Losing Dad & Finding Purpose00:34:52The Reality of Being 300lbs00:40:17Blood Work & Kidney Health00:45:22Coming Off vs. Cruising00:58:198,000 Calories & The McDonald's Diet01:08:49Growth Hormone & Insulin Protocols01:13:01Injection Sites: The "Ass Fat" Method01:15:51Sleep Apnea & The Death Rattle01:21:15The Secret to Transformation01:36:02The Disney World Scooter Incident01:37:49Gaining 50lbs in One Cycle01:45:07Dosage Evolution (Year 1 to Pro)01:51:23Crying While Force Feeding01:58:17Current Cycle Reveal02:09:26Training: Volume vs. Intensity02:15:20The "Death Cocktail" Prep Cycle02:23:12Essential Health Supplements02:45:07Final Message to the World

Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)Ever wonder how much your liver really affects your overall health and weight? The liver plays a central role in metabolism, yet its importance is often underestimated.In this week's episode, we spoke with Dr. Rajvanshi, a board-certified gastroenterologist, hepatologist, and obesity medicine specialist at Valley Medical Center in Riten, Washington. Beyond his clinical practice, he's a health technology entrepreneur, developing AI tools to support obesity medicine for both clinicians and patients, and he is actively involved in the Obesity Medicine Association.Topics we covered include:The Liver: More Than a Detox OrganLiver Damage Can Be ReversedFatty Liver to Fibrosis: What You Need to KnowWhy Fatty Liver Screening Is EssentialSupplements vs. Real Nutrition for Liver HealthAlcohol's Impact on Your LiverModern Treatments: Resmetirom, Semaglutide, and Liver HealthMany people think of the liver simply as the body's detoxifier, but it's far more complex and vital. It supports metabolism, nutrient processing, and overall health. Understanding and maintaining liver health is key to long-term wellness, especially when it comes to weight management and metabolic health.Dr. Rajvanshi's approach highlights a modern principle in medicine: treat the root causes, not just the symptoms. By addressing liver care alongside metabolic health and obesity medicine, clinicians can help patients prevent serious complications, reduce the need for invasive treatments, and improve quality of life.For a deeper dive into how these insights translate into real-life health and weight outcomes, the full conversation is well worth a listen.Connect with Dr. Rajvanshi.:LinkedIn: Pankaj Rajvanshi, MD, Dipl. ABOMConnect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com

Listen in as Jay H. Shubrook, DO, FACOFP, FAAFP, and Chrisopher Weber, MD, FAAP, FACP, CSCS, daBOM, FOMA, discuss the latest advances in caring for patients with overweight or obesity in the primary care setting, including:The Lancet Commission's new obesity definitions and diagnostic criteriaKey data on incretin-based antiobesity medications like semaglutide and tirzepatideBest practices for patient discussionsStrategies for incorporating new evidence in your primary care practicePresentersJay H. Shubrook, DO, FACOFP, FAAFPProfessor and DiabetologistDepartment of Clinical Sciences and Community HealthTouro University California College of Osteopathic MedicineVallejo, CaliforniaChristopher Weber, MD, FAAP, FACP, CSCS, daBOM, FOMABariatric Services Medical Director, Ascension WisconsinObesity Medicine Director, Ascension Columbia St Mary's Bariatric CenterTrustee, Obesity Medicine AssociationAdjunct Assistant Professor of PediatricsMedical College of WisconsinMilwaukee, WisconsinLink to full program:https://bit.ly/4rG7QQp Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Join me in todays episode Retatrutide and it's place within bodybuilding. I break down the science jargon into easily digestible chunks and explain why it might be favoured over the likes of Semaglutide. I also give my experience of using it with client during their prep and the benifits/negatives that came with it. If you are looking to join the team then please enquire today. 2025 client results: Overall x 5 1st x 63 2nd x 28 3rd x 13 Follow me on instagram: @prepcoachuk

I've received a number of questions about GLP1s and knee pain/osteoarthritis and in this series we'll look at what the research says.In part 1 we'll look at the trial for semaglutide and knee osteoarthritis.In part 2 we'll look at 2 studies that consider the effects of metformin on knee osteoarthritis.In part 3 we'll look at a study of a weight-neutral intervention Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Mood, Behavior, and Quality of Life in Parkinson Disease," Sneha Mantri, MD, MS, Chief Medical Officer at the Parkinson's Foundation, discusses how mood and behavioral symptoms shape the lived experience of people with Parkinson disease across the disease course. Mantri, a practicing movement disorders specialist with extensive training and experience, explains why depression and anxiety often precede motor symptoms, how these issues evolve with cognitive change, and why they remain key drivers of quality of life. Mantri reviews commonly used screening tools – including the PHQ-2/9, Geriatric Depression Scale, GAD-7, and emerging measures like the HOPE questionnaire – emphasizing their role in opening deeper clinical conversations. She also highlights Parkinson's Foundation initiatives that support both clinicians and patients, from PD Health at Home programming to team-based care models. The conversation concludes with ongoing challenges, including cultural barriers to mental health care, access limitations, and the continued need for true mental health parity in Parkinson disease management. Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page. Episode Breakdown: 1:10 – How mood and behavior symptoms shape Parkinson disease quality of life 5:30 – How conversations about mental health in Parkinson disease have evolved 9:25 – Screening tools and practical assessment strategies for mood and anxiety 13:40 – Neurology News Minute 15:50 – Foundation and community initiatives supporting mood and behavior care 19:50 – Remaining gaps, cultural barriers, and mental health parity challenges The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: CTAD Presentation Lays Insights Into Disappointing Phase 3 EVOKE Trial of GLP-1 Semaglutide in Alzheimer Disease Gene Therapy ETX101 Demonstrates Significant Effects on Seizure Reduction, Neurodevelopmental Outcomes in POLARIS Phase 1/2 Program FDA Accepts NDA for Low-Sodium Oxybate TRN-257 in Narcolepsy and Idiopathic Hypersomnia Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Fueled by cancer, obesity and cardiovascular deals, $1 billion-plus takeouts in biotech are at their highest level in a decade with three weeks to go in the year. On the latest BioCentury This Week, BioCentury's analysts discuss the rise in large M&A deals and what the trends among the 37 acquisitions say about biopharma dealmaking.The analysts assess first-in-human in vivo CAR T data at the American Society of Hematology meeting from Kelonia Therapeutics, which showcase the promise of the modality and justify the growing pipeline. They also break down readouts from Praxis in developmental and epileptic encephalopathy from the American Epilepsy Society Annual Meeting and from Novo Nordisk, which presented full data at the Clinical Trials on Alzheimer's Disease meeting on semaglutide's failure to treat Alzheimer's disease.Washington Editor Steve Usdin analyzes a roller-coaster week at FDA in which Richard Pazdur resigned as director of FDA's Center for Drug Evaluation and Research and Tracy Beth Høeg became acting CDER director, a move that Usdin says will prompt staff departures, ease restraints on FDA leadersView full story: https://www.biocentury.com/article/657781#BiotechMA #CARTTherapy #EpilepsyResearch #AlzheimersDisease #FDA02:37 - Biotech M&A06:39 - In vivo CAR T10:08 - Semaglutide for Alzheimer's16:17 - Praxis22:11 - FDATo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 – Intro00:02:28 – Remote vs. In-Person Peaking00:03:50 – Data Driven Coaching00:06:13 – First Cycle Philosophy00:09:31 – Post-Show Buffer Protocol00:11:02 – The Estrogen Myth00:14:14 – The Calcium Score Imperative00:15:59 – The Vitamin D3 Danger00:17:49 – Death by Potassium00:20:23 – Halo vs. Superdrol00:27:37 – Thyroid Tapering00:30:59 – Western Medicine vs. Bodybuilding00:33:16 – The Rebound Phase00:37:42 – Female Androgen Health Effects00:44:31 – Metformin vs. Berberine00:48:18 – Myostatin & The Future of PEDs00:52:23 – Training is what matters most00:58:00 – Fixing Back Training01:05:26 – From Dietitian to Super Coach01:14:32 – Insulin Sensitivity & Gut Health01:23:03 – Peak Week Glucose & GI Health Management01:31:01 – The Dyazide Strategy01:41:02 – The GLP-1 Trap01:54:31 – Classic Physique Weight Cuts01:56:14 – Stanimal Case Study02:09:48 – Insulin & HGH Synergy02:15:42 – Why Modern Bodybuilding is Soft02:21:35 – Designing the Offseason Cycle02:37:05 – Waist Control Secrets02:40:33 – Nick Walker & Coaching02:43:27 – Female PED Safety02:52:36 – Fertility & Sperm Banking02:55:40 – The Final Message

Novo Nordisk's highly anticipated data for semaglutide in Alzheimer's dashed hopes that the GLP-1 therapy could become a game changer in the disease. On the latest BioCentury This Week podcast, Executive Editor Selina Koch discusses the Phase III readout including what it says about the mechanism's use in the neurodegenerative disease, Novo's decision to skip Phase II and enroll a large patient group in a later stage trial, and what other datasets for GLP-1s in the indication have shown.Washington Editor Steve Usdin explains why FDA's new vaccine policies, driven by CBER Director Vinay Prasad, could have impacts more far-reaching than expected, including making it more difficult to develop or modify vaccines. And Lauren Martz, Executive Director of Biopharma Intelligence, analyzes the bleak investment outlook for cell and gene therapy companies in the U.S. and why China's biotech ecosystem offers a glimmer of hope for sponsors of these assets.View full story: https://www.biocentury.com/article/657721#Semaglutide #GLP1Therapies #VaccinePolicy #CellAndGeneTherapy #AlzheimersResearch00:00 - Introduction01:53 - Novo's Alzheimer's Miss13:19 - FDA's New Vaccine Policy19:53 - Funding C> BiotechsTo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

How he improved drastically from his last year with Jansen - Did he deserve to beat Urs?  ⁨@Quintbeastwood⁩  YoungLA BLACK FRIDAY SALE: https://www.youngla.com/discount/nyleCode ‘NYLE' for 30% off to support the podcastThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 – Intro00:08:41 – Why This Was His Best & Most Consistent Season Ever00:14:05 – How Much Easier This Prep Was vs. Matt Years00:19:40 – The New York Pro That Broke Him00:26:47 – Off-Season Weight, Calories & Smarter Approaches00:36:55 – Peak Week Breakdown: Depletion + Carb Loads00:44:00 – Glutamine Mega-Dosing & Gut Health for Peak Week00:47:21 – Germany Show Was His Favorite Trip Ever00:49:34 – What Quinton Packs for Overseas Shows00:55:26 – Running Almost No Orals vs. Winstrol Experiment01:00:17 – Managing a Tiny Waist on Stage01:04:34 – Water Manipulation Mistakes & Lessons01:10:09 – Why Self-Coaching Gave Him His Best Season Ever01:13:50 – Salt, Spillover & Why Judges Prefer Fuller Looks01:19:00 – The Look Judges Want From Quinton01:23:17 – When You Can't See Yourself Objectively01:25:17 – Judges Reward Muscle Pressure Over Shape01:34:19 – Staying Smiling & Confident on Stage01:46:31 – Bodybuilding Pulled Him Through Ruts01:53:06 – PPL vs. Bro Split Thoughts01:56:56 – New Health Phase: Cardio & Controlled Food02:01:23 – Balancing Opinions With Self-Analysis02:04:26 – Prioritize Training Above All02:09:10 – Peptide Recovery: MOTS-C & BPC-15702:20:15 - Leg Cramps02:29:44 – Brittany Brought Life Balance02:32:32 – Say “F*** It” & Take Risks02:33:41 – Kidney Health on Point02:35:55 – Message to the World: More in Common02:38:48 – Closing Thanks & Giant Potential

Send us a textGood morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve deep into a series of transformative events that underscore the dynamic nature of our industry, where scientific innovation meets regulatory evolution and market adaptation.We begin with significant regulatory news from Medicare, which recently announced price reductions for 15 prescription drugs, including Novo Nordisk's semaglutide products, Ozempic and Wegovy. This initiative is part of the Inflation Reduction Act aimed at making essential medications more affordable. By potentially increasing accessibility to these treatments, this move highlights a growing trend towards cost containment in drug pricing within the U.S. healthcare system. It reflects a broader effort to ensure that life-saving treatments remain within reach for more patients, emphasizing the need for balance between innovation and affordability.Turning to approvals, Otsuka has secured FDA clearance for Voyxact, a first-in-class treatment targeting IgA nephropathy (IgAN). This positions Otsuka in an increasingly competitive market space populated by major players like Novartis and Vertex. The entry of Voyxact could pave the way for innovative therapeutics in kidney diseases, offering new hope to patients who have had limited treatment options until now.On the other side of the Atlantic, French authorities have conducted a raid on Sanofi's headquarters as part of a tax fraud investigation. This development sheds light on ongoing scrutiny in the pharmaceutical sector regarding financial practices and regulatory compliance. Such investigations can have far-reaching implications on corporate governance and transparency, reminding us of the importance of ethical practices in maintaining industry trust.Novo Nordisk has strategically used its FDA national priority voucher to expedite the review process for a high-dose formulation of Wegovy. This move underscores the importance of regulatory incentives in accelerating drug development timelines, allowing for quicker patient access to potentially life-changing therapies. It's a testament to how strategic navigation through regulatory pathways can significantly impact drug availability.In clinical trials, Sarepta Therapeutics received FDA clearance to conduct a study combining its gene therapy Elevidys with sirolimus in patients with Duchenne muscular dystrophy. The study aims to address liver safety issues associated with Elevidys, which had led to previous label restrictions. This reflects the industry's commitment to enhancing therapeutic safety profiles while expanding treatment indications.In oncology advancements, AstraZeneca's Imfinzi received FDA approval for use in early-stage stomach cancer, marking its third perioperative indication. This approval underscores the expanding role of immunotherapy across various cancer types and stages, offering new treatment paradigms that could improve surgical outcomes and long-term patient survival.Despite these advances, there is skepticism regarding artificial intelligence's role in regulatory compliance submissions among pharmaceutical professionals. A survey reveals that 65% express distrust towards AI-generated outputs, highlighting challenges that AI technologies face in gaining acceptance within highly regulated environments such as pharmaceuticals. However, federal recommendations to revamp U.S. biotechnology research emphasize incorporating AI into scientific processes to maintain global competitiveness. This call reflects concerns over potential declines in innovation leadership and underscores the need for strategic investment in research infrastructure.In antitrust news, the Federal Trade Commission (FTC) outlined its case agaiSupport the show

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Send us a textGood morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're diving into a series of impactful events and breakthroughs that are shaping patient care and drug development.The U.S. Food and Drug Administration recently granted early approval for a combination therapy using Padcev and Keytruda for the perioperative treatment of bladder cancer, a decision made months ahead of schedule. This approval represents a significant advancement in the therapeutic landscape for this type of cancer, offering new hope to patients who have had limited treatment options. The combination of these two therapies underscores the growing trend of integrating multiple mechanisms of action to tackle complex diseases like cancer more effectively. It also highlights the potential of combination therapies to provide enhanced clinical benefits by leveraging different therapeutic targets.In another notable development, Merck's partner Kelun announced successful Phase 3 trial results for an antibody-drug conjugate combined with Keytruda in treating PD-L1-positive non-small cell lung cancer (NSCLC). The trial results demonstrated statistically significant improvements in progression-free survival compared to Keytruda alone. This finding reinforces the expanding role of antibody-drug conjugates in oncology and emphasizes the importance of biomarker-driven therapies in personalizing cancer treatment. These advancements reflect a broader industry shift towards precision medicine, which aims to improve patient outcomes by tailoring treatments based on individual patient profiles.Meanwhile, Novo Nordisk experienced setbacks as its shares fell nearly 9% following two unsuccessful Phase 3 trials of semaglutide for Alzheimer's disease. Despite these disappointing results, this outcome highlights the persistent challenges and complexities inherent in developing therapies for neurodegenerative diseases—areas where unmet needs remain substantial. The market's reaction reflects investor sensitivity to clinical trial outcomes, particularly in high-stakes areas like Alzheimer's where breakthroughs are eagerly anticipated.Switching gears to AstraZeneca, the company is making a strategic move by expanding its manufacturing capabilities with a $2 billion investment in Maryland. This expansion reflects an ongoing trend among pharmaceutical companies to enhance their production infrastructure, driven by increasing demand for biologics and complex therapeutics. Such investments are crucial for supporting large-scale production needs and ensuring robust supply chains that are essential for meeting global health demands.In regulatory news, a collective letter from biotech CEOs addressed to FDA director Marty Makary has raised concerns about regulatory stability in the U.S., with 82% of biopharma respondents expressing apprehension over the FDA's ability to function predictably. This plea underscores how regulatory volatility can hinder innovation and emphasizes the importance of consistent policies that support long-term research and development efforts.In clinical trial updates, Bayer's oral FXIa inhibitor asundexian has shown promise in reducing stroke risk during Phase 3 trials. These findings revive interest in FXIa inhibitors as potentially blockbuster drugs after previous setbacks in this class. This development illustrates ongoing efforts to identify novel anticoagulant therapies that balance efficacy and safety, offering new hope for improved therapeutic options.Now turning our attention to Johnson & Johnson's recent setback with their anti-tau antibody posdinemab in a phase 2 trial targeting Alzheimer's disease. The trial was unable to demonstrate a significant slowing of clinical decline, leading JSupport the show

We tell you why a judge has dismissed the federal cases against a former FBI director and New York's Attorney General. Ukraine and Russia are at odds over the latest version of President Trump's peace plan. The Pentagon could court martial a Democratic senator for what he said in a recent video post. An NBA coach had his day in court in the alleged gambling scheme case. Plus, a new clinical trial shows the limits of popular weight loss drugs. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Dean St. Mart returns.YoungLA BLACK FRIDAY SALE: https://www.youngla.com/discount/nyleCode ‘NYLE' for 30% off to support the podcastThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 Intro00:06:11 NHS Hospital Nightmare & Surgery Delays00:17:45 Enhancement Perspective – Shoes, Tech & Humanity00:22:32 Fast vs Slow Metabolizers Explained00:30:19 Best Injection Sites: Glutes vs Delts00:38:01 10 Grams of Test 00:45:00 Posing Injuries & Calf Cramp Story00:55:19 Dean's Full 2024 Contest Prep Cycle01:05:31 Reps in Reserve Revolution – Growing With Less Drugs01:21:03 Low-Dose Stack – Slow & Steady Wins01:32:45 Stomach Acid & Bile: First Line of Defense01:42:09 Androgenic Overload – Hair Loss & Acne Signals01:52:51 Modern Abuse: 3–4g Doses Without Results02:06:26 Why Coming Off Gear Can Boost Gains02:15:14 GH Dosing Deep Dive02:24:41 SubQ vs IM GH Absorption Debate02:32:49 Systemic vs Local Effects (GH & IGF-1)02:39:11 Protecting Your Future Health02:40:12 Podcast Wrap & Goodbye

In this episode, Dr. Taves and Dr. Sarah Thomas explore how GLP-1 weight loss drugs—such as Ozempic, Wegovy, and Mounjaro—may influence headaches and migraines. They break down how these medications work in the body, how blood sugar stability impacts migraine symptoms, and why some people notice improvement while others experience worsening headaches.They also discuss an important but often overlooked consideration: even if GLP-1 medications help with weight loss or migraine symptoms, there may be other factors to think about before relying on them long-term. From side effects to the difference between symptom management and addressing the root cause, this episode helps listeners understand the full picture so they can make informed decisions.Novera: Headache Center

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Welcome back to Ozempic Weight Loss Unlocked, the show where we break down the latest developments in weight loss medications and what they mean for your health. I'm your host, and today we're diving into some exciting new data and industry shifts that you need to hear about.Let's start with what's happening right now in the weight loss medication world. A recent systematic review of over forty thousand adults found that semaglutide and tirzepatide significantly outperform older medications in achieving meaningful weight loss. In clinical trials, semaglutide resulted in a fourteen point nine percent reduction in body weight over sixty eight weeks, while tirzepatide led to a twenty point nine percent reduction. That's substantial progress compared to earlier options like liraglutide, which delivered only four to five percent weight loss.But here's something important our listeners need to understand: clinical trial results don't always match real world outcomes. When researchers looked at actual users after one year, those taking semaglutide lost seven point seven percent of their body weight, and those on tirzepatide lost twelve point four percent. Why the difference? About fifty percent of patients discontinued treatment during that first year, and eighty percent took lower dosages than prescribed.Speaking of usage, the numbers are staggering. Approximately one in eight American adults, or around twelve percent, have used a glucagon like peptide one medication at some point. Among people diagnosed with diabetes, that number jumps to forty three percent. The average age of users in the United Kingdom is forty four years old, with people aged forty to fifty nine making up more than half of all users.Now let's talk money, because cost remains a major barrier. The monthly out of pocket cost for Ozempic in the United States can reach as high as twelve hundred dollars for uninsured individuals. This pricing has created a competitive marketplace. In November twenty twenty five, Pfizer won a bidding war with Novo Nordisk to acquire obesity drug developer Metsera, giving them injectable and oral glucagon like peptide one candidates expected to enter clinical trials soon.But there's even more competition coming. Research indicates that several pharmaceutical companies including AstraZeneca, Zealand Pharma, Roche, and Amgen are expected to enter the glucagon like peptide one market with multiple drug launches planned between twenty twenty seven and twenty thirty two.Interestingly, a new alternative is emerging. A medication called eloralintide, which targets a different hormone called amylin instead of glucagon like peptide one, showed promising results. In a phase two clinical trial with two hundred sixty three participants, those receiving eloralintide experienced average weight loss between nine and twenty percent after forty eight weeks, compared to only zero point four percent in the placebo group. Up to ninety percent of participants on eloralintide improved by at least one body mass index category, and the study showed improvements in cardiometabolic risk factors including waist circumference, blood pressure, and blood sugar management.Our listeners should know that not everyone responds equally to these medications. Past studies show that as much as seventeen percent of glucagon like peptide one users may be non responders to the medication. This is why having multiple treatment options with different mechanisms of action matters so much.One final note worth mentioning: the rise in glucagon like peptide one use has sparked increased demand for cosmetic surgeries to remove loose skin following significant weight loss. Procedures like arm lifts, thigh lifts, and tummy tucks have all seen increased demand.Thank you so much for tuning in to Ozempic Weight Loss Unlocked. Please make sure to subscribe so you don't miss our next episode covering even more developments in this rapidly evolving space. This has been a Quiet Please production, for more check out quiet please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Why are so many people still feeling “off” after COVID?From dizziness to fatigue, brain fog to stress, chest tightness to confusion… millions are searching for answers.In this episode, CRNA and author Kristina Morros shares her firsthand perspective from the front lines of the pandemic and what she's seen after it: including the aftereffects people rarely talk about, the confusing rise in brain and heart symptoms, and why so many still don't feel like themselves.We address the questions people are typing into Google every day:Why do I still feel dizzy after COVID?Can COVID cause brain fog or confusion?What body systems are affected by COVID-19 long-term?Are these brain-related symptoms normal after COVID?Why do some people report memory issues after COVID or the vaccine?Is sore throat after the COVID vaccine common?Are these symptoms long COVID or something else?Can inflammation after COVID improve?How do I start healing when doctors don't have answers?Kristina also shares how COVID impacted society, why the healthcare system struggled, and why so many people feel unsure about their symptoms today whether from COVID itself, stress, lifestyle changes, or fear around possible vaccine side effects.But this conversation is ultimately about hope: your body can heal, you're not alone, and there are practical daily steps people are using to feel normal again.⭐ CHAPTERS[0:00:00] Introduction & Book Title "Get Healthy or Get Dead[0:02:55] Personal Discipline & Health Choices[0:10:17] COVID-19 Vaccines & Healthcare Critique[0:17:54] Alternative Treatments & Health System Issues[0:28:05] Semaglutide, Quick Fixes & Pharmaceutical Industry[0:40:05] Motivation & Coaching Techniques[0:48:11] Daily Health Routine & Lifestyle Changes[0:51:38] Resources & Closing Remarks⭐ RESOURCESKristina Morros “Get Healthy or Get Dead”Website: gethealthyorgetdead.com❤️ If this episode brings you clarity or hope, share it with someone who needs it.aftereffects of covid, aftereffects of covid 19, covid 19 side effects, post covid symptoms, lingering symptoms after covid, covid dizziness, covid brain fog, covid brain damage symptoms questions, can covid cause confusion, what body systems are affected by covid 19, covid neurological symptoms, covid heart symptoms, covid inflammation, feeling off after covid, covid recovery questions, covid recovery tips, long covid vs vaccine questions, covid vaccines and memory loss concerns, sore throat after covid vaccine question, nurse explains covid, covid health issues, post covid healing, how to feel normal after covid, covid effects on society, covid fatigue recovery, brain symptoms after covidThis episode was powered by BUZOPS Gym Growth OS - A complete, powerful and flexible solution to manage every aspect of your gym operations. Get exceptional features thoughtfully designed to make your life easier while growing exponentially and achieving business success. BUZOPS empowers you to flawlessly automate administrative tasks and optimize access management to your facilities, synchronizing effortlessly with member accounts, staff management, class bookings, scheduling, individual services, and user-friendly comprehensive business reports.

Friends, let's talk about the "poopy" subject nobody wants to discuss! My colonoscopy prep was a complete rollercoaster experience, and I believe my GLP-1 medication was the reason. If you're on Ozempic, Wegovy, or Mounjaro and suffer from constipation, you must watch this before your procedure! I'm sharing the extended prep tips and advice you need to discuss with your doctor.Don't let this happen to you! Share this with someone you love and join us in our journey toward a healthy, wealthy, and happy life!Support the show✨ Stay Connected & Level Up Your Life! ✨

Takeaways:Drug transfer during lactation is complex and challenging.Semaglutide was not detected in women taking any dose.Low amounts of tears epitide were found in milk.Tissue damage can affect drug absorption.Mastitis and engorgement complicate the lactation process.Injections are necessary for effective drug delivery.The analogy of an elephant illustrates the difficulty of drug transfer.Detection of drugs in milk is a critical concern for breastfeeding mothers.Understanding turnover is essential in lactation studies.The implications of drug transfer on women's health are significant.Infant Risk Center Link  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Clinical Pharmacist, Author, Board-Certified Clinical Nutritionist, and Health Expert Jim LaValle details the many health benefits of aged garlic extract, particularly its impact on periodontal disease. He reveals exciting new research findings that show Kyolic Aged Garlic Extract supplements can significantly reduce periodontal pocket depth -- a key indicator of gingivitis and periodontal disease progression. He also highlights the role of aged garlic extract in reducing inflammation and improving gum health, which in turn has significant implications for cardiovascular and cognitive health. The conversation also touches on various formulations of aged garlic extract available from Kyolic, the importance of integrative approaches to health and wellness, and updates on the latest trends in anti-aging medicine, including peptides and GLP-1 agonists.

Dr. Hoffman continues his conversation with clinical pharmacist, author, board-certified clinical nutritionist, and health expert Jim LaValle on the many health benefits of aged garlic extract.

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Hello, friends. It's been a while, but I'm back! In this video, I'm sharing an honest life update about where I've been and why I've been away.From being locked out of my Google account and feeling a bit lost, to a major update on my 85-pound weight loss journey, I'm sharing it all. I've gone through a lot of changes recently, including retiring from the military, and now I'm ready to figure out what's next for this channel.I'd love to hear from you! Please leave a comment and let me know what content you'd be interested in watching: more on weight loss, lifestyle, or business?Thank you for sticking with me. Let's get this community going again!✨ Stay Connected & Level Up Your Life! ✨

4th at Olympia 2025, 5th at Olympia 2025, & Prague Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:10:13 Sleep Stack: Melatonin, GABA, L-Theanine00:16:34 Pittsburgh Pro Miss & Mental Reset00:20:36 Olympia Flatness vs. Prague Peak00:25:12 Prague Peak Recipe Perfection00:31:10 Olympia Migraine Backstage00:35:23 Earlier Hammer Drop (6 Weeks Out)00:40:20 Strict Salt/Water Tracking (10g/5L)00:44:49 Pulling Test Early in Open vs. Classic00:53:18 Yo-Yo Feeding Strategy01:00:36 TB-500 & BPC-157 for Injuries01:04:47 Winstrol Sides & Inflammation01:10:16 Blue Collar to Pharmacy Journey01:18:23 Beating 5 Mr. Olympia Champs01:24:49 Data-Driven Confidence01:34:29 Anti-Shrink Secrets01:36:48 Slow Gains, Max Detail01:44:41 Videographer Coop Magic01:47:18 Cream of Rice Hack01:51:17 Water Retention Balance01:55:24 Fat-Holding Edge02:01:03 Lean Protein Choices02:03:21 Muscle Fatigue Battles02:08:00 X-Frame Strategy02:11:14 Dehydration Balance02:12:47 Parabolan PED Vibes02:15:21 Bloodwork Monitoring02:20:03 Insulin Off-Season Use02:23:01 Insulin & Cardio Effects02:27:00 Insulin & Blood Pressure02:30:00 Insulin & Test Levels02:33:30 Glutamine GI Benefits02:36:45 Tips for Sport Success02:40:56 Grateful for Bodybuilding02:44:33 Journey Support Thanks

Listen in as Kristin chats with Dr Angela Kwong, a Sydney-based General Practitioner with a special interest in medically supervised weight management, about the use of GLP-1 agonists. Dr Kwong serves as the NSW State Lead for the RACGP Specific Interests Group in Obesity Management and works closely with colleagues across disciplines to improve care for people living with obesity. She is also the founder of Enlighten Me, a multidisciplinary online program that provides evidence-based, GP-led support for patients seeking weight management. The program has been recognised for its contribution to patient education and its focus on accessible, stigma-free care. Additional GLP-1 reading: 1. GLP-1 agonist role in renal protection - FLOW Trial 1a. Digestible summary of the FLOW trial 2. Current ANZCA guidelines for anaesthesia / sedation in patients using GLP-1 agonists (May 2025) 3. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

Send us a textChris Broomhead is a bodybuilder, personal trainer and coach, educator, entrepreneur, and advocate for science-backed performance & health. After 14+ years competing in bodybuilding, he is now dedicated to cutting through hype in health and performance.Today, Chris focuses on GLP-1s and peptides, such as Semaglutide, Tirzepatide, Retatrutide, teaching how science and lifestyle work together for resilience, longevity, and transformation.Find Chris at-IG- @Chris_Broomhead_researchYT- @Chris Broomhead CoachingFind Boundless Body at- myboundlessbody.com Book a session with us here!

Olympia 2025 for 212 bodybuilding shocked people. John Jewett took over Shaun's prep for Olympia and brought an unexpected package vs. Keone Pearson.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 – Intro02:31 - Catching up08:44 – Why Competing Overseas Is a Nightmare12:36 – Judge Feedback: Fuller + Chest/Quads20:51 – Shaun Clarida's Best Olympia Peak Ever24:00 – Rebounding After 2024 Olympia30:33 – Peak Week Strategy: Simple Always Wins32:27 – Managing Backstage Chaos at Olympia36:20 – Zero Diuretics for Shaun Clarida41:15 – Peaking Pro Tip: Start Simple44:41 – Data Logging = Perfect Peaks45:30 – Shaun's 182lb Magic Window48:53 – Fake GH? What Happens When It's Pulled50:01 – Clen Mistakes & Monster Carb Loads56:00 – Simple Peaks Beat Complicated Protocols58:30 – Martin Fitzwater's MONSTER Fill-Out01:00:47 – Sodium Strategy: 3–5g Daily01:06:57 – Backstage Snacks: Glucose vs Fructose01:12:10 – The 3-Exercise Pump Routine01:18:33 – Winstrol Experiment: Fuller but Softer01:25:28 – If You Could Only Run One Steroid…01:26:51 – SuperDrol: Bull Mode01:32:23 – Shaun's Training: Less Volume, More Gains01:38:40 – Fasted vs Fed Cardio01:43:04 – Steady-State Wins for Conditioning01:50:42 – Cutting the GI Protocol Down01:58:22 – Retatrutide Update & Lipid Focus02:00:14 – Masteron Muscle Myth Busted02:04:16 – Biggest Regret: Should've Hired a Coach02:06:09 – Pro Life: Keep Showing Up02:16:24 – Final Message

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Meta-analysis of MI as a surrogate https://pubmed.ncbi.nlm.nih.gov/34694318/ Compare Acute Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1701067 DANAMI-3–PRIMULTI 10.1016/S0140-6736(15)60648-1 External Link CULPRIT-SHOCK https://www.nejm.org/doi/full/10.1056/NEJMoa1710261   II  Huge Cardiac News for Patients with ESRD PISCES article EMBARGOED Till 1130 AM EST PISCES Trial www.nejm.org/doi/full/10.1056/NEJMoa2513032 REDUCE-IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1812792 STRENGTH Trial https://jamanetwork.com/journals/jama/fullarticle/2773120 FISH trial https://jamanetwork.com/journals/jama/fullarticle/1150094 III Obesity Agents White House announces deal with Lilly and Novo on GLP-1 drugs https://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/ Amylin Agonists Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf Eloralintide Phase 2 Study https://doi.org/10.1016/S0140-6736(25)02155-5 GLP-1 Comparisons SURMOUNT-5 Trial https://www.nejm.org/doi/10.1056/NEJMoa2416394 Tirzepatide vs Semaglutide in 10-year CVD Risk Reduction https://doi.org/10.1093/ehjopen/oeaf117 IV A Problematic Trial in Stroke Care LAMP trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840370 V AHA Preview AHA 2025: Mandrola's Four Trials to Look For https://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Email List: ⁠https://huntershealthhacks.beehiiv.com/⁠Get My Book On Amazon: ⁠⁠https://a.co/d/avbaV48Download⁠⁠The Peptide Cheat Sheet: ⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠1 On 1 Coaching Application: ⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠Book A Call With Me: ⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠Supplement Sources: ⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠Amazon Storefront: ⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠Socials:Instagram: ⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠Video Topic Request: ⁠⁠https://hunterwilliamsvideotopic.carrd.co/In this episode, I dive deep into what I believe could be the most powerful synergy in the entire world of longevity and metabolic optimization — the combination of SGLT2 inhibitors (like Jardiance and Farxiga) with GLP-1 agonists (like Retatrutide, Tirzepatide, and Semaglutide).These medications were originally created for diabetics, but what we're learning now is that they may be rewriting the entire playbook on healthspan and lifespan extension. I break down the research showing how SGLT2 inhibitors not only lower blood glucose but also improve cardiovascular health, protect the kidneys, reduce inflammation, and even clear senescent cells — all while mimicking the effects of caloric restriction and fasting.Then, I explain how pairing them with a GLP-1 creates a metabolic symphony unlike anything else we've ever seen. Together, they reduce insulin resistance, improve energy metabolism, and activate the same longevity pathways linked to caloric restriction, AMPK activation, and mitochondrial renewal.If you care about living longer, staying leaner, and protecting every organ system in your body, this episode is a must-listen. I share what I've seen personally, what's happening in clinical data, and why I believe the GLP-1 + SGLT2 combo could end up being one of the greatest discoveries in modern medicine for both health and performance.

GLP-1 medications like Ozempic®, Wegovy®, and Mounjaro® are changing the weight-loss landscape, but there's more to the journey than watching the scale move. In this episode, we break down 4 essential considerations everyone on a GLP-1 should know.With Mindy's science-based and trustworthy expertise, these are the considerations to protect your health during and after medication use:1. Preventing Lean Muscle Mass loss and Osteoporosis2. Managing GI Issues3. Preventing nutrient deficiencies 4. Build Healthy HabitsThis episode is supportive, judgment-free, and packed with actionable takeaways. Whether you're on a GLP-1, considering one, or supporting someone who is, this conversation will leave you feeling empowered and informed. References:Wong, ND, et al. US Population Eligibility and Estimated Impact of Semaglutide.  Cardiovasc Drug Ther. 2023Wong, ND, et al.  Population Eligibility and Estimated Impact of Semaglutide.  Cardiovasc Drug Ther. 2024 Chakhtoura, M., et al. Pharmacotherapy of obesity: EClinicalMedicine, 2023 Volek J, et al. Nutritional Considerations During Major Weight Loss.  Curr Nutr Rep. 2024Meslon E, et al.  What is the pipeline for future medications in obesity? Nature. 2024Martin CK, et al.  Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial.  Nat Med. 2025Dilly A, et al.  Characteristics and food consumption for current, previous, and potential consumers of GLP-1s.  Food Quality and Preference.  2025;129;105507We are so glad you are here. Want to stay in touch?Follow us on social media: Sweat and Laughter podcast - @sweat.and.laughter.podcast Mindy - @strongover40_dietitian Cheryl - @training.with.cheryl Mindy & Cheryl - @mcfitadventures Email us: mcfitadventures@gmail.com Thank you so much for listening to Sweat & Laughter. M & C

Welcome back to the Dr. Kinney Show!In this solo episode, I'm diving deep into one of the most talked-about topics in wellness right now, GLP-1 medications, including Ozempic, Wegovy, and semaglutide. There's a lot of information (and misinformation) circulating about these drugs, and I want to explain how they actually work, when they can be incredibly effective, and when they can cause more harm than good.I break down the glucose-insulin connection, what insulin resistance really means, and why inflammation often begins with blood sugar imbalance. I also share how these medications can be used as a powerful tool for improving insulin sensitivity, reducing inflammation, and supporting hormone balance, when used thoughtfully and at the right time.In this episode, I discuss:How glucose and insulin function together to fuel your bodyWhat happens when insulin resistance develops and why it leads to fatigue, weight gain, and inflammationHow GLP-1 medications like semaglutide work to increase insulin sensitivityWhy microdosing or using the lowest therapeutic dose can be safer and more effectiveThe difference between short-term weight loss and long-term metabolic healthCommon side effects and how to avoid them with proper dosing and timingThe importance of building muscle and eating enough protein before starting a GLP-1 medicationHow these medications can reduce “food noise” and improve mental clarityThe unexpected benefits for hormone balance, PCOS, and menopause symptomsWhy GLP-1s should be seen as a supportive tool, not a quick fixWhether you're curious about GLP-1 medications for weight management, inflammation, or metabolic health, this episode will help you understand how to use them in a way that truly supports your body's healing process.https://www.thekinneyclinic.com/book

2025 Olympia, Family, PED's, & From The Start Til NowThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 – Intro00:01:42 – Marriage & Relationship Challenges During Prep00:04:27 – Filipino Inspiration & Bodybuilding Legacy00:07:15 – Coaching Joven to the Olympia00:11:09 – Rebuilding After the 2018 Crash00:14:25 – Top 10 Validation & Shutting Down Haters00:16:56 – Stoik Gym: Local Grind to Global Expansion00:21:18 – 18-Hour Prep Days: Building the Blueprint00:25:24 – Fatherhood Struggles During Prep00:31:25 – PED Awareness & Brain Chemistry00:35:07 – Downfall Lessons & Accountability00:43:18 – OCD Since Age 6: Pain to Empathy00:48:59 – Career Rollercoaster & Public Perception00:56:09 – Stoik Vision: Pros Building Pros00:59:46 – Attitude Kills Deals: Losing Everything01:03:18 – The Total Package: Physique + Communication01:06:41 – Backstage Battles & God's Plan01:12:54 – TRT, Peptides & Health Optimization01:17:02 – Proud Dad Shift: Value Beyond Stage01:26:45 – Recovery Mindset: Faith & Muscle Memory01:31:15 – Diet Is King: 5–6 Meals Over Gear01:35:57 – Final Message: Treat People Right, Kill Loneliness

Olympian & 3x Classic Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 - Intro01:26 - Starting Chat and Merch Talk10:35 - Early Training & First Competition20:32 - Post-Show Binge & Taco Bell Story27:07 - Dessert Obsession & Mukbang Talks33:17 - Low Libido in Prep & Recent Wins36:12 - Dealing with Losses & Growth Mindset40:24 - Embracing Suffering & Process48:23 - Lessons from Last Season & Positivity54:17 - Pressure, Stability & Financial Struggles56:01 - Vegas Trip & First Flights1:03:07 - Travel Strategies & Pro Lifestyle1:12:18 - Hardships, Inspiration & Adversity1:16:12 - Competing Against Daniel & Stage Reality1:18:59 - Tanning & Glaze Lessons1:25:16 - Backstage Anxiety & Timing Errors1:31:08 - Pump Timing & Anxiety in Prep1:46:55 - Classic Division Surprise & Point System1:52:54 - Passion for Competing & Vegas Vibes01:55:07 - Post-Show Health & Growth Strategy2:02:09 - Progress Pics & Cycle Breakdown2:07:20 - Low Dose Philosophy & Longevity2:10:28 - Lab Work & Supplement Insights2:31:09 - Posing Flow State & Stage Confidence2:34:52 - Prep Reduces Anxiety & Staying Ready02:39:38 - Gut Health & Peak Week Tactics2:44:31 - Back Weakness & Training Fixes2:48:15 - Olympia Predictions & Expo Stage Chat3:00:39 - Final Show Reflections & Lessons3:03:29 - Olympia Hype & Vegas Linkup Plans03:04:26 - Control What Matters & Gratitude3:05:24 - Clothing Deals & Meeting Appreciation3:06:29 - Transparency & Meaningful Impact3:07:09 - Vegas, Brownies & Farewell

#bodybuilding #TRT #Muscle #Contestprep #bodybuildingpodcastULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING Link -⁠ ⁠⁠⁠⁠⁠https://bodybuilderinthailand.com/ultimate-guide-to-roids/⁠⁠⁠⁠⁠⁠Daily Text Msg Training 99/month and 1 Hour Phone Call Consult 59 Send Email to inquire about personal training to steroidspodcast@gmail.comBodybuilder in Thailand on Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/bodybuilderinthailand/⁠⁠⁠⁠My Other Podcast: Grab the Bull Podcast:⁠⁠⁠https://youtu.be/X6SzfCrN4NY?si=Ho2T9WIVxLjXo_AE⁠0:00 Preference for Test Propionate - Combining testosterone propionate and enanthate6:56 1st Cycle Lifting for 4 years natural with gyno from puberty11:41 Dbol Gets a Bunch of Shit Thrown at It14:55 Family Guy using tirzepatide and TRT testosterone. Looking for a good first cycle. Effects of Gear while dieting.19:42 Daily Superdrol as a First Cycle, but not trying to be Huge. Scared of Needles. 28:47 Adding Masteron to get a Big Libido 34:15 Enclomiphene - HCG - Nolvadex for Testosterone Boosting43:13 Testosterone Sustanon and Primo cycle - Sustanon Explained45:25 Old school bodybuilders had better skin49:50 Retatrutide Results - GLP1 Agonists Semaglutide Tirzepatide and Retatrutide ComparedThis Podcast is for entertainment and conversational purposes only. Serious Injury and Death can occur from utilizing chemical performance enhancement. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. The purpose of this podcast is not to glorify the use of PED's but to bring to light the reality of what athletes are doing privately. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.

Leyla Muedin, a registered dietitian nutritionist, discusses the gastrointestinal (GI) side effects commonly experienced by patients using GLP-1 medications such as Ozempic and Rybelsus. Leyla introduces a nutraceutical called Digexin, created by N-X-T-U-S-A, which has shown promise in mitigating these side effects and improving overall well-being. The episode highlights the need for patients to prioritize animal protein intake and incorporate strength training to maintain muscle mass, especially when taking GLP-1 medications. Leyla emphasizes the importance of developing healthy habits and lifestyle changes to sustain weight loss after discontinuing these drugs.

Olympian in 212 and now Classic.  @thedurrah  The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro03:19 - Carb Up & Diuretics08:45 - Lineup Drama & Feedback15:19 - Full vs Dry Debate20:58 - Bloodwork Wins & Health Markers25:43 - Water Retention & Dosing40:32 - Schedule Stress & Experience Edge50:06 - 212 vs Classic Prep57:48 - Surgery Loss to Suicide Shift01:03:48 - Quick Q&A & Peak Strategies01:06:26 - Future Moves & Olympia Cycle01:11:39 - Rebound Tips & Self-Coaching01:13:37 - Fatherhood Paradox & Olympia Path1:17:46 - Peace Out

Hitting a metabolic wall in midlife? You're not alone — and you're not broken. In this episode, Michele Folan, midlife health coach and former diabetes industry insider, breaks down the science (and the truth) behind microdosed GLP-1 and peptide therapy for women 40+.Drawing on many years in diabetes and cardiovascular health, Michele explains how incretin hormones like GLP-1 and GIP regulate appetite, satiety, and insulin sensitivity — and why they've become game-changers for both metabolic and weight health. You'll hear:The wild origin story of GLP-1 (hint: it starts with the Gila monster)Why early GLP-1 drugs revolutionized diabetes careHow microdosing protocols now support fat loss while protecting lean muscleThe real goals: improved A1C, fasting insulin, lipids, inflammation, and energyThis isn't about shortcuts — it's about layering science-backed tools onto strong habits: ✅ Lifting heavy ✅ Eating enough protein ✅ Prioritizing recovery ✅ Partnering with trusted, physician-led telehealth and vetted compounding pharmaciesMichele also dives into other longevity peptides that support sleep, recovery, cognition, skin, and hair health — plus the role of NAD+ in cellular repair and energy.If you've been “doing everything right” and still feel stuck, this episode connects the dots between modern peptide therapy and midlife metabolism — with zero hype and total transparency.

✨ The GLP-1 Circle Membership is opening the doors soon, available for all GLP-1 users, it's your hub for dietitian/personal trainer support on your GLP-1 journey for only $99/month. Get first dibs on membership spots here: Join the waitlist

AI accelerates drug discovery while steroids turn teens into aggressive strangers. Dr. Michael Israetel explores our pharmaceutical crossroads here!Full show notes and resources can be found here: jordanharbinger.com/1209What We Discuss with Michael Israetel:GLP-1 drugs like Tirzepatide offer massive health benefits beyond weight loss — reducing inflammation, improving brain health, and decreasing addiction behaviors, even for people already in good shape.Steroids don't just amplify personality — they specifically amplify masculine traits like aggression and reduce empathy. Starting young can permanently rewire your brain's emotional and social processing.AI is about to revolutionize medicine by testing millions of drug candidates virtually, creating treatments 10x more effective with 10x fewer side effects. We're entering the pharmaceutical iPhone moment.The "only take drugs when sick" mindset worked in the 20th century, but is becoming dangerously outdated — like refusing elevators because you prefer human operators.When your diet plateaus, take a week-long break eating at maintenance. Your stress hormones will drop, body water will flush out, and you'll often look leaner than before.And much more...And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors:Saily: 15% off: saily.com/jordanharbinger, code JORDANHARBINGERDripDrop: 20% off: DripDrop.com, code JORDANLinkedIn Jobs: Post your job for free: linkedin.com/jordanQuince: Free shipping & 365-day returns: quince.com/jordanBetterHelp: 10% off first month: betterhelp.com/jordanSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.