Podcasts about semaglutide

Why are so many people still feeling “off” after COVID?From dizziness to fatigue, brain fog to stress, chest tightness to confusion… millions are searching for answers.In this episode, CRNA and author Kristina Morros shares her firsthand perspective from the front lines of the pandemic and what she's seen after it: including the aftereffects people rarely talk about, the confusing rise in brain and heart symptoms, and why so many still don't feel like themselves.We address the questions people are typing into Google every day:Why do I still feel dizzy after COVID?Can COVID cause brain fog or confusion?What body systems are affected by COVID-19 long-term?Are these brain-related symptoms normal after COVID?Why do some people report memory issues after COVID or the vaccine?Is sore throat after the COVID vaccine common?Are these symptoms long COVID or something else?Can inflammation after COVID improve?How do I start healing when doctors don't have answers?Kristina also shares how COVID impacted society, why the healthcare system struggled, and why so many people feel unsure about their symptoms today whether from COVID itself, stress, lifestyle changes, or fear around possible vaccine side effects.But this conversation is ultimately about hope: your body can heal, you're not alone, and there are practical daily steps people are using to feel normal again.⭐ CHAPTERS[0:00:00] Introduction & Book Title "Get Healthy or Get Dead[0:02:55] Personal Discipline & Health Choices[0:10:17] COVID-19 Vaccines & Healthcare Critique[0:17:54] Alternative Treatments & Health System Issues[0:28:05] Semaglutide, Quick Fixes & Pharmaceutical Industry[0:40:05] Motivation & Coaching Techniques[0:48:11] Daily Health Routine & Lifestyle Changes[0:51:38] Resources & Closing Remarks⭐ RESOURCESKristina Morros “Get Healthy or Get Dead”Website: gethealthyorgetdead.com❤️ If this episode brings you clarity or hope, share it with someone who needs it.aftereffects of covid, aftereffects of covid 19, covid 19 side effects, post covid symptoms, lingering symptoms after covid, covid dizziness, covid brain fog, covid brain damage symptoms questions, can covid cause confusion, what body systems are affected by covid 19, covid neurological symptoms, covid heart symptoms, covid inflammation, feeling off after covid, covid recovery questions, covid recovery tips, long covid vs vaccine questions, covid vaccines and memory loss concerns, sore throat after covid vaccine question, nurse explains covid, covid health issues, post covid healing, how to feel normal after covid, covid effects on society, covid fatigue recovery, brain symptoms after covidThis episode was powered by BUZOPS Gym Growth OS - A complete, powerful and flexible solution to manage every aspect of your gym operations. Get exceptional features thoughtfully designed to make your life easier while growing exponentially and achieving business success. BUZOPS empowers you to flawlessly automate administrative tasks and optimize access management to your facilities, synchronizing effortlessly with member accounts, staff management, class bookings, scheduling, individual services, and user-friendly comprehensive business reports.

In this episode, hosts Diana Isaacs, PharmD, and Natalie Bellini, DNP, review two major developments in diabetes care: the forthcoming 15-day Dexcom G7 continuous glucose monitor (CGM) and significant new price reductions for semaglutide as Ozempic and Wegovy. Key Episode Timestamps 00:00:01 Introduction 00:00:30 Dexcom G7 00:01:55 A 15-Day Sensor With a 12-Hour Grace Period 00:04:27 Seamless transition to the new G7 00:05:23 Looking back at Dexcom's advancements 00:06:34 Dexcom's Smart Basal feature 00:10:34 Price cuts for semaglutide - Wegovy and Ozempic 00:14:54 Cheaper GLP-1s on the pharmacies' end 00:20:33 Outro

Friends, let's talk about the "poopy" subject nobody wants to discuss! My colonoscopy prep was a complete rollercoaster experience, and I believe my GLP-1 medication was the reason. If you're on Ozempic, Wegovy, or Mounjaro and suffer from constipation, you must watch this before your procedure! I'm sharing the extended prep tips and advice you need to discuss with your doctor.Don't let this happen to you! Share this with someone you love and join us in our journey toward a healthy, wealthy, and happy life!Support the show✨ Stay Connected & Level Up Your Life! ✨

Takeaways:Drug transfer during lactation is complex and challenging.Semaglutide was not detected in women taking any dose.Low amounts of tears epitide were found in milk.Tissue damage can affect drug absorption.Mastitis and engorgement complicate the lactation process.Injections are necessary for effective drug delivery.The analogy of an elephant illustrates the difficulty of drug transfer.Detection of drugs in milk is a critical concern for breastfeeding mothers.Understanding turnover is essential in lactation studies.The implications of drug transfer on women's health are significant.Infant Risk Center Link  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Hoffman continues his conversation with clinical pharmacist, author, board-certified clinical nutritionist, and health expert Jim LaValle on the many health benefits of aged garlic extract.

Clinical Pharmacist, Author, Board-Certified Clinical Nutritionist, and Health Expert Jim LaValle details the many health benefits of aged garlic extract, particularly its impact on periodontal disease. He reveals exciting new research findings that show Kyolic Aged Garlic Extract supplements can significantly reduce periodontal pocket depth -- a key indicator of gingivitis and periodontal disease progression. He also highlights the role of aged garlic extract in reducing inflammation and improving gum health, which in turn has significant implications for cardiovascular and cognitive health. The conversation also touches on various formulations of aged garlic extract available from Kyolic, the importance of integrative approaches to health and wellness, and updates on the latest trends in anti-aging medicine, including peptides and GLP-1 agonists.

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Hello, friends. It's been a while, but I'm back! In this video, I'm sharing an honest life update about where I've been and why I've been away.From being locked out of my Google account and feeling a bit lost, to a major update on my 85-pound weight loss journey, I'm sharing it all. I've gone through a lot of changes recently, including retiring from the military, and now I'm ready to figure out what's next for this channel.I'd love to hear from you! Please leave a comment and let me know what content you'd be interested in watching: more on weight loss, lifestyle, or business?Thank you for sticking with me. Let's get this community going again!✨ Stay Connected & Level Up Your Life! ✨

Ocular adverse events with semaglutide - Link—Nova Android & iOS app MGFamiliar - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Link⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠—Subscreva o Podcast MGFamiliar para não perder qualquer um dos nossos episódios. Além disso, considere deixar-nos uma revisão ou um comentário no Apple Podcasts ou no Spotify.—MusicSilence - LinkMusic by INOSSIListen: https://fanlink.tv/b3xgWatch:    • INOSSI -  Silence (Official)  —Este podcast destina-se a médicos e os conteúdos nele partilhados não devem ser usados para decisões individuais sem aconselhamento médico. Para tal, consulte seu médico.

4th at Olympia 2025, 5th at Olympia 2025, & Prague Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:10:13 Sleep Stack: Melatonin, GABA, L-Theanine00:16:34 Pittsburgh Pro Miss & Mental Reset00:20:36 Olympia Flatness vs. Prague Peak00:25:12 Prague Peak Recipe Perfection00:31:10 Olympia Migraine Backstage00:35:23 Earlier Hammer Drop (6 Weeks Out)00:40:20 Strict Salt/Water Tracking (10g/5L)00:44:49 Pulling Test Early in Open vs. Classic00:53:18 Yo-Yo Feeding Strategy01:00:36 TB-500 & BPC-157 for Injuries01:04:47 Winstrol Sides & Inflammation01:10:16 Blue Collar to Pharmacy Journey01:18:23 Beating 5 Mr. Olympia Champs01:24:49 Data-Driven Confidence01:34:29 Anti-Shrink Secrets01:36:48 Slow Gains, Max Detail01:44:41 Videographer Coop Magic01:47:18 Cream of Rice Hack01:51:17 Water Retention Balance01:55:24 Fat-Holding Edge02:01:03 Lean Protein Choices02:03:21 Muscle Fatigue Battles02:08:00 X-Frame Strategy02:11:14 Dehydration Balance02:12:47 Parabolan PED Vibes02:15:21 Bloodwork Monitoring02:20:03 Insulin Off-Season Use02:23:01 Insulin & Cardio Effects02:27:00 Insulin & Blood Pressure02:30:00 Insulin & Test Levels02:33:30 Glutamine GI Benefits02:36:45 Tips for Sport Success02:40:56 Grateful for Bodybuilding02:44:33 Journey Support Thanks

Listen in as Kristin chats with Dr Angela Kwong, a Sydney-based General Practitioner with a special interest in medically supervised weight management, about the use of GLP-1 agonists. Dr Kwong serves as the NSW State Lead for the RACGP Specific Interests Group in Obesity Management and works closely with colleagues across disciplines to improve care for people living with obesity. She is also the founder of Enlighten Me, a multidisciplinary online program that provides evidence-based, GP-led support for patients seeking weight management. The program has been recognised for its contribution to patient education and its focus on accessible, stigma-free care. Additional GLP-1 reading: 1. GLP-1 agonist role in renal protection - FLOW Trial 1a. Digestible summary of the FLOW trial 2. Current ANZCA guidelines for anaesthesia / sedation in patients using GLP-1 agonists (May 2025) 3. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

Send us a textChris Broomhead is a bodybuilder, personal trainer and coach, educator, entrepreneur, and advocate for science-backed performance & health. After 14+ years competing in bodybuilding, he is now dedicated to cutting through hype in health and performance.Today, Chris focuses on GLP-1s and peptides, such as Semaglutide, Tirzepatide, Retatrutide, teaching how science and lifestyle work together for resilience, longevity, and transformation.Find Chris at-IG- @Chris_Broomhead_researchYT- @Chris Broomhead CoachingFind Boundless Body at- myboundlessbody.com Book a session with us here!

Olympia 2025 for 212 bodybuilding shocked people. John Jewett took over Shaun's prep for Olympia and brought an unexpected package vs. Keone Pearson.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 – Intro02:31 - Catching up08:44 – Why Competing Overseas Is a Nightmare12:36 – Judge Feedback: Fuller + Chest/Quads20:51 – Shaun Clarida's Best Olympia Peak Ever24:00 – Rebounding After 2024 Olympia30:33 – Peak Week Strategy: Simple Always Wins32:27 – Managing Backstage Chaos at Olympia36:20 – Zero Diuretics for Shaun Clarida41:15 – Peaking Pro Tip: Start Simple44:41 – Data Logging = Perfect Peaks45:30 – Shaun's 182lb Magic Window48:53 – Fake GH? What Happens When It's Pulled50:01 – Clen Mistakes & Monster Carb Loads56:00 – Simple Peaks Beat Complicated Protocols58:30 – Martin Fitzwater's MONSTER Fill-Out01:00:47 – Sodium Strategy: 3–5g Daily01:06:57 – Backstage Snacks: Glucose vs Fructose01:12:10 – The 3-Exercise Pump Routine01:18:33 – Winstrol Experiment: Fuller but Softer01:25:28 – If You Could Only Run One Steroid…01:26:51 – SuperDrol: Bull Mode01:32:23 – Shaun's Training: Less Volume, More Gains01:38:40 – Fasted vs Fed Cardio01:43:04 – Steady-State Wins for Conditioning01:50:42 – Cutting the GI Protocol Down01:58:22 – Retatrutide Update & Lipid Focus02:00:14 – Masteron Muscle Myth Busted02:04:16 – Biggest Regret: Should've Hired a Coach02:06:09 – Pro Life: Keep Showing Up02:16:24 – Final Message

Welcome to Ozempic Weightloss Unlocked, the podcast where we break down the latest developments in semaglutide medications and what they mean for your health. I'm your host, and today we're diving into the most important updates from 2025.Let's start with what's working. Ozempic continues to demonstrate significant effectiveness for weight loss, producing mean weight reduction of fourteen point nine to seventeen point four percent over sixty eight weeks in people without diabetes. The higher dose formulation, known as Wegovy, shows even more impressive results, with studies consistently showing greater average weight loss compared to the lower doses found in Ozempic. For millions managing type two diabetes or seeking weight management solutions, these medications have become game changers.But here's what listeners need to know right now. Recent research is raising important safety concerns that demand our attention. A June 2025 study published in JAMA Ophthalmology found that patients taking semaglutide were twice as likely to develop neovascular age related macular degeneration, a condition that gradually destroys central vision. While the absolute risk remains small, researchers from the University of Toronto identified this link as statistically significant. The mechanism makes sense too. Semaglutide alters vascular and inflammatory pathways directly implicated in macular degeneration.The vision concerns aren't the only ones. A January 2025 study in JAMA Otolaryngology found that patients initiating Glucagon like Peptide One receptor agonist therapy had a significantly increased risk of thyroid cancer diagnosis within the first year of use compared to other diabetes medications. Researchers analyzed data from over three hundred fifty thousand adults with type two diabetes.Then there's gastroparesis, the stomach paralysis condition that's become central to ongoing litigation. Multiple lawsuits allege that Novo Nordisk, the manufacturer, failed to provide adequate warnings about this risk. The lawsuits argue the company knew or should have known about the potential link based on clinical studies and medical literature. Patients reported persistent vomiting, nausea, and extreme stomach discomfort after starting the medication.The legal landscape shifted in December 2024 when the Judicial Panel on Multidistrict Litigation ruled to expand the Glucagon like Peptide One receptor agonist lawsuit to include claims involving Saxenda, though blood clot related injuries were excluded due to complexity concerns.What does this mean for you? If you're considering Ozempic or Wegovy, talk to your doctor about these emerging risks alongside the proven benefits. If you're already taking these medications and experiencing vision changes, thyroid issues, or stomach problems, document everything and consult your healthcare provider.The story of Ozempic isn't finished. As evidence emerges, companies face questions not just about what they disclosed but about what they should have investigated. The scientific community continues watching as more data arrives.Thank you so much for tuning in to Ozempic Weightloss Unlocked. Please subscribe to stay updated on the latest developments in semaglutide research and safety updates. This has been a Quiet Please production. For more, check out Quiet Please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Meta-analysis of MI as a surrogate https://pubmed.ncbi.nlm.nih.gov/34694318/ Compare Acute Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1701067 DANAMI-3–PRIMULTI 10.1016/S0140-6736(15)60648-1 External Link CULPRIT-SHOCK https://www.nejm.org/doi/full/10.1056/NEJMoa1710261   II  Huge Cardiac News for Patients with ESRD PISCES article EMBARGOED Till 1130 AM EST PISCES Trial www.nejm.org/doi/full/10.1056/NEJMoa2513032 REDUCE-IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1812792 STRENGTH Trial https://jamanetwork.com/journals/jama/fullarticle/2773120 FISH trial https://jamanetwork.com/journals/jama/fullarticle/1150094 III Obesity Agents White House announces deal with Lilly and Novo on GLP-1 drugs https://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/ Amylin Agonists Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf Eloralintide Phase 2 Study https://doi.org/10.1016/S0140-6736(25)02155-5 GLP-1 Comparisons SURMOUNT-5 Trial https://www.nejm.org/doi/10.1056/NEJMoa2416394 Tirzepatide vs Semaglutide in 10-year CVD Risk Reduction https://doi.org/10.1093/ehjopen/oeaf117 IV A Problematic Trial in Stroke Care LAMP trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840370 V AHA Preview AHA 2025: Mandrola's Four Trials to Look For https://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Email List: ⁠https://huntershealthhacks.beehiiv.com/⁠Get My Book On Amazon: ⁠⁠https://a.co/d/avbaV48Download⁠⁠The Peptide Cheat Sheet: ⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠1 On 1 Coaching Application: ⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠Book A Call With Me: ⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠Supplement Sources: ⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠Amazon Storefront: ⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠Socials:Instagram: ⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠Video Topic Request: ⁠⁠https://hunterwilliamsvideotopic.carrd.co/In this episode, I dive deep into what I believe could be the most powerful synergy in the entire world of longevity and metabolic optimization — the combination of SGLT2 inhibitors (like Jardiance and Farxiga) with GLP-1 agonists (like Retatrutide, Tirzepatide, and Semaglutide).These medications were originally created for diabetics, but what we're learning now is that they may be rewriting the entire playbook on healthspan and lifespan extension. I break down the research showing how SGLT2 inhibitors not only lower blood glucose but also improve cardiovascular health, protect the kidneys, reduce inflammation, and even clear senescent cells — all while mimicking the effects of caloric restriction and fasting.Then, I explain how pairing them with a GLP-1 creates a metabolic symphony unlike anything else we've ever seen. Together, they reduce insulin resistance, improve energy metabolism, and activate the same longevity pathways linked to caloric restriction, AMPK activation, and mitochondrial renewal.If you care about living longer, staying leaner, and protecting every organ system in your body, this episode is a must-listen. I share what I've seen personally, what's happening in clinical data, and why I believe the GLP-1 + SGLT2 combo could end up being one of the greatest discoveries in modern medicine for both health and performance.

GLP-1 medications like Ozempic®, Wegovy®, and Mounjaro® are changing the weight-loss landscape, but there's more to the journey than watching the scale move. In this episode, we break down 4 essential considerations everyone on a GLP-1 should know.With Mindy's science-based and trustworthy expertise, these are the considerations to protect your health during and after medication use:1. Preventing Lean Muscle Mass loss and Osteoporosis2. Managing GI Issues3. Preventing nutrient deficiencies 4. Build Healthy HabitsThis episode is supportive, judgment-free, and packed with actionable takeaways. Whether you're on a GLP-1, considering one, or supporting someone who is, this conversation will leave you feeling empowered and informed. References:Wong, ND, et al. US Population Eligibility and Estimated Impact of Semaglutide.  Cardiovasc Drug Ther. 2023Wong, ND, et al.  Population Eligibility and Estimated Impact of Semaglutide.  Cardiovasc Drug Ther. 2024 Chakhtoura, M., et al. Pharmacotherapy of obesity: EClinicalMedicine, 2023 Volek J, et al. Nutritional Considerations During Major Weight Loss.  Curr Nutr Rep. 2024Meslon E, et al.  What is the pipeline for future medications in obesity? Nature. 2024Martin CK, et al.  Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial.  Nat Med. 2025Dilly A, et al.  Characteristics and food consumption for current, previous, and potential consumers of GLP-1s.  Food Quality and Preference.  2025;129;105507We are so glad you are here. Want to stay in touch?Follow us on social media: Sweat and Laughter podcast - @sweat.and.laughter.podcast Mindy - @strongover40_dietitian Cheryl - @training.with.cheryl Mindy & Cheryl - @mcfitadventures Email us: mcfitadventures@gmail.com Thank you so much for listening to Sweat & Laughter. M & C

Welcome back to the Dr. Kinney Show!In this solo episode, I'm diving deep into one of the most talked-about topics in wellness right now, GLP-1 medications, including Ozempic, Wegovy, and semaglutide. There's a lot of information (and misinformation) circulating about these drugs, and I want to explain how they actually work, when they can be incredibly effective, and when they can cause more harm than good.I break down the glucose-insulin connection, what insulin resistance really means, and why inflammation often begins with blood sugar imbalance. I also share how these medications can be used as a powerful tool for improving insulin sensitivity, reducing inflammation, and supporting hormone balance, when used thoughtfully and at the right time.In this episode, I discuss:How glucose and insulin function together to fuel your bodyWhat happens when insulin resistance develops and why it leads to fatigue, weight gain, and inflammationHow GLP-1 medications like semaglutide work to increase insulin sensitivityWhy microdosing or using the lowest therapeutic dose can be safer and more effectiveThe difference between short-term weight loss and long-term metabolic healthCommon side effects and how to avoid them with proper dosing and timingThe importance of building muscle and eating enough protein before starting a GLP-1 medicationHow these medications can reduce “food noise” and improve mental clarityThe unexpected benefits for hormone balance, PCOS, and menopause symptomsWhy GLP-1s should be seen as a supportive tool, not a quick fixWhether you're curious about GLP-1 medications for weight management, inflammation, or metabolic health, this episode will help you understand how to use them in a way that truly supports your body's healing process.https://www.thekinneyclinic.com/book

2025 Olympia, Family, PED's, & From The Start Til NowThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 – Intro00:01:42 – Marriage & Relationship Challenges During Prep00:04:27 – Filipino Inspiration & Bodybuilding Legacy00:07:15 – Coaching Joven to the Olympia00:11:09 – Rebuilding After the 2018 Crash00:14:25 – Top 10 Validation & Shutting Down Haters00:16:56 – Stoik Gym: Local Grind to Global Expansion00:21:18 – 18-Hour Prep Days: Building the Blueprint00:25:24 – Fatherhood Struggles During Prep00:31:25 – PED Awareness & Brain Chemistry00:35:07 – Downfall Lessons & Accountability00:43:18 – OCD Since Age 6: Pain to Empathy00:48:59 – Career Rollercoaster & Public Perception00:56:09 – Stoik Vision: Pros Building Pros00:59:46 – Attitude Kills Deals: Losing Everything01:03:18 – The Total Package: Physique + Communication01:06:41 – Backstage Battles & God's Plan01:12:54 – TRT, Peptides & Health Optimization01:17:02 – Proud Dad Shift: Value Beyond Stage01:26:45 – Recovery Mindset: Faith & Muscle Memory01:31:15 – Diet Is King: 5–6 Meals Over Gear01:35:57 – Final Message: Treat People Right, Kill Loneliness

Today, we're tackling a question that comes up often in peptide, weight loss, and nutrition clinics: why does one person see great results with semaglutide, while another responds better to tirzepatide—or even retatrutide? If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. https://pepties.com/partners/ All three peptides target the incretin system, but they act in slightly different ways—and those differences can dramatically affect outcomes. Let's start with the basics. Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics the gut hormone GLP-1, which increases insulin when blood sugar is high (to help lower blood sugar), suppresses glucagon (which also decreases blood sugar), and slows gastric emptying. It also enhances satiety—so you feel full longer and eat less. Tirzepatide is a dual agonist, acting on both GLP-1 and GIP receptors. GIP—glucose-dependent insulinotropic polypeptide—also helps with insulin secretion to lower blood sugar, increases fat metabolism, and may reduce some of the GI side effects seen with GLP-1 alone. Retatrutide, the newest in the lineup, is a triple agonist that targets GLP-1, GIP, and glucagon receptors. Retatrutide lightly activates the glucagon receptor while strongly activating GLP-1 and GIP receptors, which help regulate blood sugar and boost insulin secretion. This keeps blood sugar stable—or even improves it. Beyond blood sugar, glucagon also ramps up metabolism and calorie burning. By gently engaging glucagon receptors, retatrutide can increase energy expenditure and support fat loss without triggering large blood sugar spikes. So how do you decide which one might work best? Let's walk through common clinical situations. Patients with Hypothyroidism Let's talk about hypothyroidism. People with hypothyroidism often have slower metabolism, making weight loss more difficult even with a balanced diet. Low thyroid hormone levels slow calorie burning and energy use, so weight gain can occur more easily. For these patients, semaglutide is a reliable starting point—it helps regulate appetite and caloric intake. If progress plateaus, tirzepatide or retatrutide may provide an edge by boosting energy expenditure and fat oxidation, essentially "jump-starting" a slower metabolism. Patients with PCOS (Polycystic Ovary Syndrome) What about patients with PCOS (polycystic ovary syndrome)? Insulin resistance is common in PCOS, often leading to higher androgen levels (e.g., testosterone) and symptoms like irregular periods, acne, and excess hair growth. Hormonal changes also affect appetite-regulating hormones, increasing hunger and cravings. Both GLP-1 and dual agonists have proven effective in managing metabolic and reproductive aspects of PCOS. Typically, we start with semaglutide to improve weight, insulin sensitivity, androgen levels, and menstrual regularity. After a few months, if weight loss plateaus or cravings remain high, we may switch to tirzepatide. The added GIP activity enhances fat metabolism, insulin control, and may further support hormone regulation and ovulation. The key is starting with what's well-studied and tolerated, then stepping up if additional metabolic or reproductive support is needed. Type 2 Diabetes (T2DM) The next medical condition I'd like to talk about is type 2 diabetes (T2DM). Weight gain in T2DM often stems from insulin resistance. Cells don't respond effectively to insulin, prompting the pancreas to relelase more. High insulin levels encourage fat storage, particularly around the abdomen, while elevated blood sugar can increase hunger and cravings. Some diabetes medications, like insulin or sulfonylureas (e.g., glipizide or glyburide), can also contribute to weight gain. All three drugs lower blood sugar and promote weight loss, but tirzepatide currently shows the strongest combined A1c reduction (average blood sugar over the past 2 to 3 months) and weight loss. GIP and GLP-1 work together to enhance insulin response more effectively than GLP-1 alone. Retatrutide is in phase 3 trials, with potential FDA approval as early as 2027. Its glucagon receptor activity may offer additional glucose regulation and energy expenditure benefits. Patients with >15% Weight Loss Goals Okay, let's talk about weight loss goals and how this ties into the decision process for choosing a weight loss medication. For those patients looking to lose more than 15% of their total body weight, tirzepatide or retatrutide are likely to deliver greater results. Clinical data show semaglutide can achieve up to 15% total weight loss while tirzepatide can achieve up to 22% and retatrutide up to 24%. That said, semaglutide remains a highly effective option for weight loss. However, if progress begins to plateau, transitioning to a dual or triple agonist may help restart weight loss and push past that plateau. Pre- and Postmenopausal Women What about peri- and postmenopausal patients? Hormonal shifts during perimenopause and menopause slow metabolism and can increase cravings. Declining estrogen promotes abdominal fat storage and affects appetite-regulating hormones. Semaglutide helps with appetite control and gradual fat loss, while tirzepatide's GIP activation can further support fat metabolism when estrogen levels drop. Patients with Heart Disease or High Cholesterol The last group of patients I'd like to discuss is patients with heart disease (e.g., heart failure, stroke, heart attack, or even atherosclerosis) or people with high cholesterol. Semaglutide has the strongest cardiovascular outcomes data, reducing major adverse cardiac events by 20% and improving LDL cholesterol (bad cholesterol) and blood pressure. Tirzepatide shows promise for heart and lipid benefits, but those trials are still ongoing. For patients with prior heart attack, stroke, or severe coronary artery disease, semaglutide remains the safest evidence-backed starting point—unless intolerable side effects or weight loss resistance occur. Tolerability Now I want to switch gears a bit and talk about side effects and tolerablity of these peptides. Some patients experience stomach-related side effects like nausea, bloating, or acid reflux on semaglutide. Generally, tirzepatide tends to cause fewer GI side effects, likely due to GIP balancing GLP-1 activity in the gut. So patients struggling with nausea or other stomach-related side effects may find tirzepatide more tolerable. Just something to keep in mind. Individualizing Therapy Lastly, I want to highlight the importance of individualizing weight loss peptide treatments. There's no one-size-fits-all approach when it comes to these therapies. Clinicians should carefully consider a patient's goals, medical history, current medications, and tolerance before choosing the most appropriate option. Setting realistic expectations from the start is essential. It's important to remember that everyone's body responds differently because of factors like hormones, genetics, metabolism, gut microbiome balance, and lifestyle habits. These differences influence how effectively a peptide therapy works and how well it's tolerated. That's why ongoing monitoring and follow-up are such an important part of the process. Providers track progress, adjust dosing when needed, and switch medications if weight loss plateaus or side effects occur. The goal isn't just to lose weight quickly—it's to create a safe, sustainable plan that supports long-term metabolic health and helps patients feel their best. Thanks for listening to The Peptide Podcast.  If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Until next time, be well, and have a happy, healthy week.

Today, we're exploring the latest updates on Ozempic, a medication that's gained widespread attention for its role in weight loss. Originally approved for type 2 diabetes, Ozempic has shown significant potential in reducing body weight as a side effect. Its active ingredient, semaglutide, works by mimicking a natural hormone called glucagon-like peptide-1, which helps regulate blood sugar and appetite.Ozempic can lead to an average weight loss of about 7% of body weight over several months. However, not everyone experiences this benefit, as results can vary based on individual factors like diet and overall health. Semaglutide is also used in Wegovy, which is specifically approved for weight management and offers a higher dose.Beyond weight loss, semaglutide has been found to have cardiovascular benefits, reducing the risk of heart attacks and strokes regardless of the amount of weight lost. This suggests that its effects extend beyond just weight management.Thank you for tuning in. Be sure to subscribe for more updates on Ozempic and other health topics. This has been a Quiet Please production, for more check out Quiet Please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Olympian & 3x Classic Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 - Intro01:26 - Starting Chat and Merch Talk10:35 - Early Training & First Competition20:32 - Post-Show Binge & Taco Bell Story27:07 - Dessert Obsession & Mukbang Talks33:17 - Low Libido in Prep & Recent Wins36:12 - Dealing with Losses & Growth Mindset40:24 - Embracing Suffering & Process48:23 - Lessons from Last Season & Positivity54:17 - Pressure, Stability & Financial Struggles56:01 - Vegas Trip & First Flights1:03:07 - Travel Strategies & Pro Lifestyle1:12:18 - Hardships, Inspiration & Adversity1:16:12 - Competing Against Daniel & Stage Reality1:18:59 - Tanning & Glaze Lessons1:25:16 - Backstage Anxiety & Timing Errors1:31:08 - Pump Timing & Anxiety in Prep1:46:55 - Classic Division Surprise & Point System1:52:54 - Passion for Competing & Vegas Vibes01:55:07 - Post-Show Health & Growth Strategy2:02:09 - Progress Pics & Cycle Breakdown2:07:20 - Low Dose Philosophy & Longevity2:10:28 - Lab Work & Supplement Insights2:31:09 - Posing Flow State & Stage Confidence2:34:52 - Prep Reduces Anxiety & Staying Ready02:39:38 - Gut Health & Peak Week Tactics2:44:31 - Back Weakness & Training Fixes2:48:15 - Olympia Predictions & Expo Stage Chat3:00:39 - Final Show Reflections & Lessons3:03:29 - Olympia Hype & Vegas Linkup Plans03:04:26 - Control What Matters & Gratitude3:05:24 - Clothing Deals & Meeting Appreciation3:06:29 - Transparency & Meaningful Impact3:07:09 - Vegas, Brownies & Farewell

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Today we're talking about peptides being researched for addiction. We'll unpack the science behind the incretin system, how those pathways tie into reward and substance use, and focus in on the newest triple‐agonist retatrutide. We'll also look at early evidence for alcohol, tobacco and other substance-use disorders when using certain peptide therapies. If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. https://pepties.com/partners/ What are GLP-1, GIP and the “dual/triple” agonists? First, let's review some biology to ground the discussion. GLP-1 (glucagon‐like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) are incretin hormones. Incretins are gut hormones that help with digestion and blood sugar control. They're released by the gut in response to food.  GLP-1 raises insulin levels after you eat to help lower blood sugar, slows gastric emptying, and reduces appetite. It also reduces how much glucagon your body makes. This helps to lower your blood sugar. Medications like semaglutide and dulaglutide work by mimicking GLP-1 and are often referred to as “GLP-1 agonists”. GIP has somewhat overlapping but distinct roles from GLP-1. It too, influences insulin secretion, but it also helps with fat metabolism.  In a nut shell, GIP helps fat cells respond more efficiently to insulin so they release stored fat to be used as energy when your body needs it. This process helps your metabolism shift from just storing energy to burning fat for fuel. Medications like tirzepatide work by mimicking both GLP-1 and GIP and are often referred to as “dual” agonists.  When GIP and GLP-1 are activated together — like in tirzepatide — they work as a team: GLP-1 helps control appetite and slow down digestion. GIP boosts how your body handles insulin and energy. Together, they help reduce hunger, improve metabolism, and burn fat more efficiently. Now here's where it gets a bit tricky.  A newer medication that's still in development, retatrutide, works on three hormone pathways: GLP-1, GIP, and glucagon receptors. It's called a “triple agonist”, and even though it activates the glucagon receptor, it doesn't cause high blood sugar like you might expect. It's about balance. In type 2 diabetes and obesity, the body's hormone signals are out of balance. Retatrutide gently activates the glucagon receptor, but at the same time it strongly activates GLP-1 and GIP receptors — which still help control blood sugar and increase insulin. So blood sugar stays stable or even improves overall. Glucagon doesn't just affect blood sugar — it also increases metabolism and helps the body burn fat and calories. By slightly stimulating glucagon receptors, retatrutide can boost energy use and promote fat loss without causing big spikes in blood sugar. As a result, you get the blood sugar control of GLP-1 and GIP, plus the fat-burning benefits of glucagon activation — leading to even greater weight loss and metabolic improvement.  Right now, retatrutide is in phase 3 clinical trials, which are the final stage of testing before approval. These studies are expected to finish in early 2026, and if results look good, the FDA could approve retatrutide as early as 2027.  Addiction Why is this relevant for addiction? Because the gut-brain axis, reward circuitry, and the pathways that regulate “wanting/consuming” food overlap with those involved in substance use.  Appetite, reward, and craving may share neural substrates (dopamine, GABA, mesolimbic system) and so a drug that reduces drive to eat might also modulate drive to drink, smoke or use other substances. The link between GLP-1/related drugs and substance use disorders  Let's now dive into what the research says about GLP-1 receptor agonists (and related medications) in the context of alcohol, tobacco, and other substances. Let's start with what we know from animal research. In pre-clinical studies, scientists have found that GLP-1 receptor agonists seem to change how animals respond to addictive substances. A systematic review showed that in rodents, treatment with GLP-1 drugs reduced the behavioral effects of alcohol, nicotine, amphetamine, and cocaine. For example, one GLP-1 drug called exendin-4 reduced alcohol-related behaviors in rodents. And even more recently, a study in both male and female rats showed that giving semaglutide, tirzepatide, or even retatrutide, reduced alcohol discrimination, meaning the rats didn't experience the same “feeling” from alcohol as before. This means that the “interoceptive stimulus effects” or the internal sensations — how alcohol feels inside the body, changed. This is really important because this is what often drives people to drink or relapse. So, if these medications can blunt those internal cues, it suggests they might disrupt the rewarding effects of alcohol that help maintain addiction. When we shift to human studies, things get even more interesting. A systemic review found that out of five studies looking at GLP-1 receptor agonists in people with substance use disorders — mostly alcohol and nicotine — three showed real reductions in substance use, while two did not. In one large observational study of over 150 adults with obesity who drank alcohol, those who were taking semaglutide or tirzepatide for at least 30 days reported fewer drinks, fewer binge episodes, and lower overall intake compared to people not on those drugs. A phase 2 clinical trial of once-weekly semaglutide in adults with alcohol use disorder showed similar results — lower alcohol craving and some reductions in drinking behavior. There's also data from a massive registry-based study showing that people with alcohol or opioid use disorder who were prescribed GLP-1 or GIP drugs had 50% lower rates of alcohol intoxication and a 40% lower rate of opioid overdose. Still, experts are cautious — meta-analyses and reviews consistently note that the evidence, while promising, is still early and we don't yet have large, long-term randomized controlled trials. What's Going On? So, what's actually happening inside the brain and body that could explain these changes in craving and reward? How can medications originally made for diabetes and/or weight loss end up helping with addiction?” Mechanistically, GLP-1 drugs may affect the brain's reward system — especially dopamine signaling in areas like the nucleus accumbens — and reduce the “wanting” of reward substances like food or alcohol. They might also calm stress responses and make relapse cues less powerful. And there are probably some physical effects too — things like slower digestion and increased fullness, which might make it harder to physically consume large amounts of alcohol or even smoke as much. But again, many of these findings come from animal models, which don't always perfectly reflect human addiction. Most of the focus so far has been on alcohol, though there's also some early evidence that GLP-1 drugs might influence nicotine use. For substances like opioids or cocaine, the data is thinner and more mixed. Bottom line — at this stage, GLP-1 receptor agonists, and maybe even GIP/GLP-1 dual agonists, represent a really promising new direction for treating addiction — but it's still early days. We also don't yet have human addiction studies on retatrutide, pre-clinical data in rats show that, like semaglutide and tirzepatide, it too, reduces alcohol discrimination. In practical terms, if you're treating patients with obesity or diabetes who also struggle with alcohol or nicotine use, choosing a GLP-1 or dual agonist might offer an unexpected bonus — helping with cravings. It also gives us a new way to talk with patients about how metabolism, reward, and craving are all interconnected. But — and this is important — the data are still limited. Most studies are small, short, and often focus on people with obesity or metabolic disease rather than pure addiction. So, for now, it's an adjunctive idea, not a replacement for established therapies. We'll need larger randomized trials in people with substance use disorders to really understand who benefits, what doses work, and how long the effects last. Thanks for listening to The Peptide Podcast. If today's episode resonated, share it with a friend, please share this episode! Until next time, be well, and as always, have a happy, healthy week.

Leyla Muedin, a registered dietitian nutritionist, discusses the gastrointestinal (GI) side effects commonly experienced by patients using GLP-1 medications such as Ozempic and Rybelsus. Leyla introduces a nutraceutical called Digexin, created by N-X-T-U-S-A, which has shown promise in mitigating these side effects and improving overall well-being. The episode highlights the need for patients to prioritize animal protein intake and incorporate strength training to maintain muscle mass, especially when taking GLP-1 medications. Leyla emphasizes the importance of developing healthy habits and lifestyle changes to sustain weight loss after discontinuing these drugs.

Label changes for tranexamic acid; new approval for Tezspire; psychedelic gains Breakthrough Tx for depression; oral semaglutide approved to reduce MACE risk in T2DM; Gazyva approved for lupus.

Olympian in 212 and now Classic.  @thedurrah  The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro03:19 - Carb Up & Diuretics08:45 - Lineup Drama & Feedback15:19 - Full vs Dry Debate20:58 - Bloodwork Wins & Health Markers25:43 - Water Retention & Dosing40:32 - Schedule Stress & Experience Edge50:06 - 212 vs Classic Prep57:48 - Surgery Loss to Suicide Shift01:03:48 - Quick Q&A & Peak Strategies01:06:26 - Future Moves & Olympia Cycle01:11:39 - Rebound Tips & Self-Coaching01:13:37 - Fatherhood Paradox & Olympia Path1:17:46 - Peace Out

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're diving into some of the most significant shifts occurring in these industries, touching on strategic restructuring, regulatory milestones, and groundbreaking scientific advancements that are shaping the future of drug development and patient care.Let's begin with a major corporate shakeup at Novo Nordisk. The company has announced a significant leadership transition as former CEO Lars Rebien Sorensen is set to become the new chairman of the board. This change follows the resignation of seven board members and indicates a strategic realignment within the company. The Novo Foundation's involvement suggests a deeper strategic shift, potentially aligning with new organizational objectives and innovations. Such moves are pivotal as they could influence Novo Nordisk's market position and future product development.Turning to scientific breakthroughs, Merck's collaboration with Kelun-Biotech has yielded promising results with their Trop2 antibody-drug conjugate, sacituzumab-tmt. This ADC has shown success in two Phase 3 trials targeting lung and breast cancers, underscoring the therapeutic potential of ADCs in oncology. By selectively targeting cancer cells while minimizing damage to healthy tissues, ADCs could significantly improve patient outcomes and represent a powerful modality in cancer treatment.In regulatory affairs, Kenvue is challenging the FDA over proposed safety warnings for Tylenol linked to autism during pregnancy. This dispute highlights the ongoing debates surrounding drug safety and regulatory oversight. The outcome could have significant implications for labeling practices and consumer trust in over-the-counter medications. Meanwhile, Summit Therapeutics plans to file for FDA approval of ivonescimab, highlighting ongoing innovation in drug development pipelines. Similarly, Novo Nordisk's semaglutide pill Rybelsus has received FDA expansion approval to reduce major adverse cardiovascular events. This sets a new benchmark for oral metabolism drugs by demonstrating their potential beyond glycemic control to positively impact cardiovascular health.As we explore industry trends, there's growing interest in direct-to-consumer drug sales. While this approach offers patients access to medications at reduced costs, it raises concerns about privacy and the quality of care without traditional healthcare provider interactions. Additionally, a notable decline in pharmaceutical TV ad spending by 19% in Q3 suggests a shift towards digital engagement strategies. Amidst these narratives, the Biotechnology Innovation Organization (BIO) has launched an awareness campaign to combat misinformation about vaccines. This effort underscores the importance of immunizations in public health and aims to reinforce trust amid rising disinformation.In another scientific advancement, GSK has released positive Phase 3 data for Spero Therapeutics' oral antibiotic candidate. The oral formulation's efficacy comparable to intravenous options could lead to broader use and improved patient adherence—critical advancements as antibiotic resistance remains a global health challenge.Investment activities reflect strategic shifts within the industry as well. Curewell Capital's investment in Wilmington PharmaTech aims to enhance U.S. active pharmaceutical ingredient production capacity—a crucial step given recent global supply chain disruptions. Similarly, India's ACG is making a $200 million investment in its first U.S. empty-capsule production facility, highlighting the strategic importance of manufacturing capabilities on American soil.Galapagos' decision to wind down its cell therapy unit marks a significant strategic pivot from its previous focus on this modality. This shift reflects broader industry trends where companies reassess priorSupport the show

Hitting a metabolic wall in midlife? You're not alone — and you're not broken. In this episode, Michele Folan, midlife health coach and former diabetes industry insider, breaks down the science (and the truth) behind microdosed GLP-1 and peptide therapy for women 40+.Drawing on many years in diabetes and cardiovascular health, Michele explains how incretin hormones like GLP-1 and GIP regulate appetite, satiety, and insulin sensitivity — and why they've become game-changers for both metabolic and weight health. You'll hear:The wild origin story of GLP-1 (hint: it starts with the Gila monster)Why early GLP-1 drugs revolutionized diabetes careHow microdosing protocols now support fat loss while protecting lean muscleThe real goals: improved A1C, fasting insulin, lipids, inflammation, and energyThis isn't about shortcuts — it's about layering science-backed tools onto strong habits: ✅ Lifting heavy ✅ Eating enough protein ✅ Prioritizing recovery ✅ Partnering with trusted, physician-led telehealth and vetted compounding pharmaciesMichele also dives into other longevity peptides that support sleep, recovery, cognition, skin, and hair health — plus the role of NAD+ in cellular repair and energy.If you've been “doing everything right” and still feel stuck, this episode connects the dots between modern peptide therapy and midlife metabolism — with zero hype and total transparency.

✨ The GLP-1 Circle Membership is opening the doors soon, available for all GLP-1 users, it's your hub for dietitian/personal trainer support on your GLP-1 journey for only $99/month. Get first dibs on membership spots here: Join the waitlist

Send us a textWelcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent phase 2 trial looking at the effects of once-weekly semaglutide on alcohol consumption and craving in adults with alcohol use disorder (AUD). Here we go!Once-Weekly Semaglutide in Adults With Alcohol Use Disorder (0:00 – 10:28).Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog WHAT YOU WILL LEARN: How to SCULPT YOUR MUSCLES AND TIGHTEN YOUR SKIN after weight loss! How to decrease VISCERAL FAT A new way to IMPROVE MUSCLE MASS by 30% for strength and beauty in 4 weeks DECREASE SUBCUTANEOUS FAT by 25% in 4 weekly treatments INCREASE MUSCLE DEFINITION with Emsculpt Neo A way to REHABILITATE AFTER SURGERY PRE-TREAT BEFORE SURGERY: Improve your post op joint surgery condition by increasing muscle around the joint HOW TO RECOVER Quickly AFTER CHILDBIRTH A Way to IMPROVE CORE AND PELVIC FLOOR STRENGTH How EM-Sculpt-Neo works Most of you know me as the expert in Bioidentical Hormone Pellet Replacement, but I am also expert in Skin and body care.  If my patients have problems that your PCP has not been able to solve.  I will refer you for new therapies, cutting edge treatments that work to treat your problem. The most common problem that my patients complain of is loss of muscle mass and changes in body fat that make them look old.  I found a treatment that is not a laser, but the Emsculpt Neo uses safe and effective magnetic energy plus RF treatment to reduce fat and build muscle in a 30-minute painless treatment. Today I am going to talk about a painless treatment that we offer at my medical spa, BioBalance® Skin that has just been approved by the FDA for rehab after joint surgery.  The magnetic energy (HIFEM) combined with RF energy increases muscle size and strength by 30%, dissolve fat by 25%, as well as tightens skin with the same treatment! EM Sculpt Neo is a 30-minute treatment that uses magnetic energy to make your muscles contract and is equal to thousands of crunches for 30 minutes. The RF portion breaks down subcutaneous fat in the same area.  There is no work on your part, you just lie there, and your muscles respond to the magnetic pull by increasing in size and strength.  Four sessions one week apart is the ideal number of treatments, and they come a in a package of four treatments to one area. The areas that most of us want to build muscle and lose fat in are our abs, upper arms, thighs, calves, love handles, and hips. If you need to do more than one area at a treatment you can do up to three areas, each for 30 minutes. If you have had joint surgery and need to increase your strength around that joint, EMSculpt Neo is very effective, after your doctor releases you to exercise. One of the big concerns with the new weight loss medications is that people often lose muscle as they lose weight.  This is especially common after age 40, in those people who are not on testosterone pellets. EMSculpt Neo adds a tool that can preserve or even increase muscle mass and decrease fat where you want to lose it. EMSculpt Neo for fat loss and muscle building (not for rehabilitation) should be saved for those weight loss patients who lose enough weight to achieve a BMI under 30. For the best results, we suggest a high protein low carb diet, protein, low carb diet, to give your body the building blocks for muscle tissue. We also will suggest supplements for nutrition and to abstain from alcohol to get the best results. Healthy fat loss takes combination of EMSCULPT NEO, Weight Loss Medication, activity, Low carb high protein diet.  We advise our patients over BMI of 30 to get started on weight loss first and continue diet medications while you are receiving EM-Sculpt Neo treatments. How do you lose weight without losing muscle? The Best Combination for the best results while you are losing weight on medication: EMSCULPT NEO to the areas you want to remove fat from Semaglutide or Tirzepatide medication to treat obesity for weight loss Testosterone Pellets if you are a woman over 40, and man over 50. Regular exercise like walking High protein diet Supplements to improve your ability to make muscle Who should do this EMSCULPT treatment? People who are working out but cannot do sit ups because of back injury Those folks who want fast muscle mass increase in specific areas Anyone who is on a weight loss program who is losing muscle and fat, or who has saggy skin in areas where they lost weight Patients anticipating a joint surgery Patients healing from joint surgery after PT Patients who cannot lift weights because of injury Those people who lift weights but cannot develop definition People with a Beer Belly with a lot of visceral fat Some people may not be able to enjoy this sculpting, muscle building method: We will do a free consultation before you sign up for a package of EMSculpt Neo and some patients will not get optimal results if they have any of the factors below: BMI greater than 30 Metal implants anywhere that are not titanium. Titanium is not magnetic, so it is ok to have a treatment if you have a titanium joint implant. No Rods or pins. Any pacemaker implant, pain pump under your skin, nerve stimulator or you are in the first 6 weeks post-surgery for any muscle area in the area. If you have a large abdominal hernia that was not repaired, then abdominal treatment is not advisable. You can still have other areas treated. If you have unrepaired joint damage, you can still have this treatment but let us know so we can slowly work the energy up around that joint. Those people who have a pannus, an apron of skin that hangs down below the vulva, or penis will not get enough relief from this procedure. These patients will need an abdominoplasty. This surgery is done by a plastic surgeon who removes excess skin and fat and repairs the muscles and fascia. You should not waste your money if you continue to drink alcohol while undergoing this treatment. Alcohol is a toxin and will prevent the growth of muscle and loss of body fat. Don't waste your money if you are not going to follow a low carb high protein diet during and after our treatment.  How does EMSCULPT Work? EMSCULPT combines HIFEM (High Intensity Focused Electromagnetic technology) and RF (Radio Frequency). HIFEM uses magnetic energy to contract muscles in a particular area at intensities that are not achievable with routine weightlifting. Fat tissue in the treated area is also reduced by increasing metabolic activity.  This results in Body Contouring. HIFEM is approved by the FDA for Body contouring, muscle stimulation, growth and to rehabilitate patients with injuries or after surgery. The second treatment that occurs at the same time as HIFEM is RF, Radio Frequency treatment. RF is a low frequency electromagnetic wave that heats up fat in 4 minutes to stimulate collagen and elastin to tighten skin. All this happens in 30 minutes with minimal discomfort.  4 treatments, one a month, is all that is needed to increase muscle 25% and to decrease fat by 30%, and to visibly improve skin tone. Answers to questions about this procedure: What should my diet consist of to optimize my treatment? To gain muscle you must eat your weight in pounds equivalent to grams of protein every day. E.g. If you weigh 200 lbs. and you want to gain muscle, you should eat 200 grams of protein a day. What foods should I eat to optimize my treatment? The best most concentrated protein is found in animal products-eggs, milk products, fish, chicken and red meat. What supplements will help support my treatment? You may want to supplement your diet with our BioBalance Magnesium combination twice a day, Probiotics, Creatine or Arginine and Ornithine combination. You should also take a methyl B12 and Methyl Folate while you are sculpting your body. Why can't I eat a lot of carbs and drink alcohol during or after the treatment? If you eat a high carb diet, your fat loss portion of Em-Sculpt will be limited, because whatever carb you eat over-stimulates insulin, which increases insulin resistance, and increases fat deposition. Whatever is eaten goes directly to fat again and replaces what you just lost. When can I start EMSculpt after joint surgery? After PT is completed or your surgeon releases you for exercise. Can I lift weights while I am being treated? Yes, but we advise not to lift weights the day before, the day of or the day after your EMSCULPT treatment. What does hydration have to be optimal for the treatment to work effectively? The human body is almost all water, and hydration is needed for muscle contraction. Muscles don't contract optimally when you are dehydrated. We put you on a body composition machine to both document your muscle mass and fat mass, as well as tell if you are hydrated adequately. Now that you know how EMSculpt Neo can change your body composition and build muscle, I hope you are comfortable enough to let us help you get the body you have always wanted. BioBalance Skin phone for an appointment:

Are you always thinking about food, feeling hungry, or never fully satisfied in perimenopause? You're not alone. In this episode, Claudia breaks down why food noise gets louder in midlife, the role of fluctuating hormones, and how nutrition, movement, and even how GLP-1s can help you finally feel in control.  You'll learn: How estrogen fluctuations and blood sugar dips drive constant hunger Why under-eating over 40 backfires The impact of activity level and strength training on fueling needs The role of progesterone and testosterone in appetite  How GLP-1 medications quiet food noise - and why I don't dismiss them Are you hungry for something more in midlife?   Links Mentioned Ep. 78: Undereating After 40: The #1 Habit Wrecking Your Hormones & Metabolism The Effect of Carbohydrate Intake on Strength and Resistance Training Protein Intake to Support Muscle Mass    >    LOVE THE SHOW? Please subscribe, leave a 5-star rating, review, and share with other women, so they can get the support they need in perimenopause!    CONNECT WITH CLAUDIA:  Website YouTube Instagram Facebook Inquiries   FREE RESOURCES:  Mini Training: Why You're Exhausted, Moody & Inflamed - And Why It's Not Just Your Hormones Peri-What?! The Must-Have Guide for Women 40+ Navigating Hormone Changes Perimenopause Daily Checklist HRT 3-Day Crash Course   GET SUPPORT:  Perimenopause Clarity Session The Perimenopause Method Program Perimenopause HRT Roadmap Course   PRODUCTS WE LOVE: Equip Prime Protein (Save 15% w/ code: healthcoachclaudia) Microbiome Labs Total Gut Restoration (Save 15% w/ code: claudia123) BodyHealth Reds Powder Symphony Natural Health Melatonin Glow Below Vaginal Estrogen or DHEA For more products we recommend, click HERE.

Evidence-Based Olympian IFBB Coach of pros like Jordan Hutchinson & Host of IFBB AMAThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro00:04:00 - Value of Transparency & Gear Evolution00:09:24 - Genetics and Drug Strategies00:14:10 - Post-Surgery Growth & Gear Myths00:19:30 - Smart Training & Rebound Management00:26:50 - TRT, Recovery & Tissue Retention00:32:40 - Parasympathetic Recovery & Sleep Struggles00:37:20 - Individualized Training & Overtraining Risks00:43:50 - Smart vs Hard Training Myths00:48:24 - Chest & Leg Training Insights00:52:30 - Jordan's Olympia Prep & Peaking Strategy01:00:00 - Stress-Free Prep & Weight Management01:05:15 - Sleep Hacks & HRT Checkups01:09:04 - James' Prep & Fullness vs Condition01:15:20 - Fruit, Food & Force-Feeding Myths01:22:00 - Gear Balance & Client Collaboration01:26:20 - Retatrutide & New Drug Cautions01:29:29 - Fat Loss Stories & Microdosing01:33:15 - Prep Catastrophes & Client Communication01:38:08 - Offseason & Reverse Diet Strategies01:51:28 - Post-Show & GH Timing Tips02:01:10 - Sugar Timing & Glycemic Control02:06:54 - Stage Experiences & Confidence02:12:11 - Carb Cycling02:24:41 - How Chris Started with James 02:34:10 - Chest Support Pads Restricting Stretch02:38:46 - Final Question

2x Mr. Olympia Runner-Up, 2x Arnold Classic Champ, USAF Veteren, one of the greatest posers of this era & potentially of all time, and one of the top contenders for the Classic Mr. Olympia title in 1 weekThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 Intro2:19 Breathing Fixes in Prep4:29 Coaching Shift & Gym Updates00:07:13 Pricing Real Talk00:08:19 Success Mindset 16:01 Olympia Plans & Prize Money Talk 18:38 Mr Olympia Beyond Bodybuilding00:21:46 Weider Influence & Sport Growth 27:05 Stage Setup & Judge Analysis 31:46 Jose's Improvements 36:59 Years Left in the Sport 41:42 NY Pro Peak 45:52 Carb Boost Strategy 49:43 Dehydration Fatigue 55:15 Rhomboid Focus 1:02:04 RPG Love 01:07:29 Friend Support 01:15:53 Olympia Packing Insight 1:25:33 Training Priority 1:34:05 Life Purpose Beyond BB 01:38:15 Legacy Building 01:45:03 Hair Transplant & Aesthetic Shift 01:54:21 Transformation 02:05:00 Final Message

GLP-1 medications like semaglutide and tirzepatide — better known as Ozempic, Wegovy, and Mounjaro — are transforming lives through significant weight loss. But along with the health benefits, many patients notice unexpected changes in their appearance: facial hollowing, skin laxity, and body deflation, often referred to as “Ozempic face.”   In this episode of The Aesthetic Doctor Podcast, Dr. Judith Borger explores how GLP-1s affect both the face and body — and what can be done to support our weight loss patients through these changes. Whether you're a a patient curious about safe, effective ways to restore balance and confidence or a provider looking to expand your toolkit of non-surgical treatment, this conversation offers practical strategies, safety insights, and compassionate guidance for navigating the GLP-1 journey.   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Recorded live at Leverage Fitness, so please excuse the background noise.                        Hear what we have to say about: Longevity - Lifespan vs Healthspan Taking a look inside - why getting more extensive bloodwork is vital Weight Loss simplified - calories in vs calories out Medications, Prescriptions and Dietary Aids - deciding which might be best for you Nutrtion - do you have to eat healthy to be healthy? Supplements - which are the most important to consider? Sleep - how does it affect weight, energy and recovery? Taking control when feeling overwhelmed  Gym myths     APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com

PhDc endo & expert on bodybuilding pharmacology & enhanced bodybuilding scienceWatch it: https://www.youtube.com/watch?v=LXErTWYFxBM&lc=Ugyh4j4EKOMWMx7bCDd4AaABAg.ANg5e8KTLa5ANgOVCTnFlCThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 Intro00:04:06 Book Updates & GH Research00:08:55 GH, DHT & Acromegaly00:13:29 GLP-1 & Offseason Nutrition00:18:10 Classic vs Open Bodybuilding00:24:31 Leg Growth & Fiber Types00:28:41 Time Off Gear & Recovery00:34:49 Training Frequency & Volume00:41:18 Prep Cycles & Orals00:46:48 Diet & Fullness Strategies00:49:36 Moving & Compound Reactions00:51:32 GI Health & Peptides00:55:49 Cardio & Skin Thickness01:03:05 Sleep Solutions & Aids01:10:32 Choline & Cognitive Health01:12:20 Surgery Recovery & Female HGH01:18:17 Blood Pressure & Hematocrit01:25:10 Cardio, Fat Loss & Yohimbine01:33:08 Favorite Bodybuilders & GH Dosing01:39:43 GH Injecting best practices01:43:53 Final Message to the world

Dr. Jerry Haas, director of our weight management program, is back with an update on the Signature Skinny Shot. After nearly two years, he and patient coordinator Lauren have fine-tuned the program with monthly check-ins, dose adjustments, and ongoing support.Dr. Haas explains how GLP-1 medications work and clears up TikTok myths with real medical data. He shares the benefits he's seen in our patients so far, from better energy and healthier blood sugar levels to being able to enjoy exercise again.He also talks about what happens once you start hitting your goals, like how to protect your muscle mass, when to shift to a maintenance dose, and what it looks like to eventually come off the medication while maintaining a healthy lifestyle.This isn't a quick fix or a magic wand, but with the right guidance, it's a powerful tool to help you feel healthier, stronger, and more in control of your weight than ever before. Find out the perks of getting your weight loss meds through a plastic surgery center instead of your primary care doctor.LinksLearn more about the Signature Skinny Shot prescription weight loss programsGet to know San Diego skinny shot director Dr. Gerald HaasLearn from the talented plastic surgeons inside La Jolla Cosmetic Surgery Centre, the 12x winner of the San Diego's Best Union-Tribune Readers Poll, global winner of the 2020 MyFaceMyBody Best Cosmetic/Plastic Surgery Practice, and the 2025 winner of Best Cosmetic Surgery Group in San Diego Magazine's Best of San Diego Awards.Join hostess Monique Ramsey as she takes you inside LJCSC, where dreams become real. Featuring the unique expertise of San Diego's most loved plastic surgeons, this podcast covers the latest trends in aesthetic surgery, including breast augmentation, breast implant removal, tummy tuck, mommy makeover, labiaplasty, facelifts and rhinoplasty.La Jolla Cosmetic Surgery Centre is located just off the I-5 San Diego Freeway at 9850 Genesee Ave, Suite 130 in the Ximed building on the Scripps Memorial Hospital campus.To learn more, go to LJCSC.com or follow the team on Instagram @LJCSCWatch the LJCSC Dream Team on YouTube @LaJollaCosmeticSurgeryCentreThe La Jolla Cosmetic Surgery Podcast is a production of The Axis: theaxis.io Theme music: Busy People, SOOP

Dr. Hoffman continues his conversation with Jim LaValle, a clinical pharmacist and certified clinical nutritionist, detailing cholesterol's importance and its implications for cardiovascular health. 

September is Cholesterol Education Month. In this episode of Intelligent Medicine, Jim LaValle, a clinical pharmacist and certified clinical nutritionist, details cholesterol's importance and its implications for cardiovascular health. He delves into the nuances of cholesterol types, the historical shifts in perceptions of cholesterol, and how dietary and lifestyle factors influence cholesterol levels and cardiovascular risk. Jim provides expert insights into the roles of LDL and HDL cholesterol, the significance of cholesterol particle size, the impact of carbohydrates on cholesterol, and the benefits of aged garlic extract and other supplements. The conversation emphasizes the importance of comprehensive lipid testing, understanding individual risk factors, and integrating both lifestyle modifications and, when necessary, medications into cardiovascular preventive strategies. The episode concludes with a discussion on the role of health policies and the future of integrative health approaches.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-451 Overview: The obesity epidemic has fueled a demand for weight loss medications. Trials have directly compared medications—specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—with a recent study doing just that. Tune in as we explore the evidence comparing semaglutide and tirzepatide for weight loss outcomes up to 1 year. Episode resource links: Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. 2024;184(9):1056-1064.  Moiz A, Filion KB, Toutounchi H, et al. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials. Ann Intern Med. 2025;178(2):199-217.  Wen J, Syed B, Nadora D, et al. Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies. Endocrinol Diabetes Metab. 2025;8(3):e70045.  Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-451 Overview: The obesity epidemic has fueled a demand for weight loss medications. Trials have directly compared medications—specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—with a recent study doing just that. Tune in as we explore the evidence comparing semaglutide and tirzepatide for weight loss outcomes up to 1 year. Episode resource links: Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. 2024;184(9):1056-1064.  Moiz A, Filion KB, Toutounchi H, et al. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials. Ann Intern Med. 2025;178(2):199-217.  Wen J, Syed B, Nadora D, et al. Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies. Endocrinol Diabetes Metab. 2025;8(3):e70045.  Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Send us a textWhat if everything you thought you knew about weight loss was wrong? In this powerful conversation, Joey Pinz sits down with Dr. David Plourdé—scientist, author of Solving the Weight Loss Puzzle, and founder of The Plourde Method—to uncover the real science behind lasting fat loss.Dr. Plourdé shares insights from 34 years in the lab, where he studied fat cells, food addiction, and the hidden forces sabotaging our health. From uncovering insidious carbs in everyday foods to exposing the dark side of weight-loss drugs like Ozempic, his revelations will make you rethink nutrition, exercise, and the role of psychology in transformation.✨ Top 3 Highlights:

AI accelerates drug discovery while steroids turn teens into aggressive strangers. Dr. Michael Israetel explores our pharmaceutical crossroads here!Full show notes and resources can be found here: jordanharbinger.com/1209What We Discuss with Michael Israetel:GLP-1 drugs like Tirzepatide offer massive health benefits beyond weight loss — reducing inflammation, improving brain health, and decreasing addiction behaviors, even for people already in good shape.Steroids don't just amplify personality — they specifically amplify masculine traits like aggression and reduce empathy. Starting young can permanently rewire your brain's emotional and social processing.AI is about to revolutionize medicine by testing millions of drug candidates virtually, creating treatments 10x more effective with 10x fewer side effects. We're entering the pharmaceutical iPhone moment.The "only take drugs when sick" mindset worked in the 20th century, but is becoming dangerously outdated — like refusing elevators because you prefer human operators.When your diet plateaus, take a week-long break eating at maintenance. Your stress hormones will drop, body water will flush out, and you'll often look leaner than before.And much more...And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors:Saily: 15% off: saily.com/jordanharbinger, code JORDANHARBINGERDripDrop: 20% off: DripDrop.com, code JORDANLinkedIn Jobs: Post your job for free: linkedin.com/jordanQuince: Free shipping & 365-day returns: quince.com/jordanBetterHelp: 10% off first month: betterhelp.com/jordanSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Shana Hussin, RDN, shares the replay of her recent webinar on GLP-1 — the hormone behind today's most popular weight loss drugs like Ozempic, Wegovy, and Mounjaro. You'll learn: ✔️ What GLP-1 is and how it works in the body ✔️ Natural ways to increase GLP-1 for fewer cravings, better blood sugar, and fat loss ✔️ Lifestyle habits that decrease GLP-1 and fuel insulin resistance ✔️ The truth about GLP-1 medications: cost, side effects, and sustainability ✔️ How to safely transition off GLP-1 drugs by improving natural GLP-1 and gut health ✔️ The research behind Unimate Yerba Mate and Balance Fiber Matrix — and how they support GLP-1 signaling in the Feel Great System ✨ If you've ever wondered whether you really need expensive GLP-1 medications, or if there's a more sustainable, root-cause solution, this episode is for you. Resources & Links:

Open Bodybuilding Olympian, 3x IFBB Pro Champion, pro podcaster in the IFBBAMA and can be often seen on Bodybuilding & Bollocks on the Real Bodybuilding Podcast.Watch it: https://youtu.be/gPfRK3HoAAYThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro to James Hollingshead04:40 Early Bodybuilding Journey and Influences09:18 Deep Dive into Nutrition and Longevity19:16 Steroid Use and Its Impact on Career26:14 Mindset and Overcoming Hardships38:00 Health Monitoring and Genetics46:20 Optimizing Training Splits57:46 Balancing Bodybuilding and Mental Health01:07:25 Dealing with Loss and Finding Purpose01:18:56 Favorite Prep Memories01:26:04 Best Peaking Show Memories01:33:27 Truth About Dosages01:45:36 Rep Ranges for Hypertrophy01:51:35 Offseason Strategy: Mass vs Conditioning01:55:24 Fertility While on Cycle01:57:14 Favorite Compounds02:00:02 Appreciating the Whole Physique02:04:23 Views on Lifting Styles02:07:51 Balancing Fatherhood and Bodybuilding02:14:45 Therapy and Travel Insights02:17:56 Final Message to the World

Olivia emailed us sharing her personal journey with Semaglutide, a GLP one receptor agonist, and how it helped her manage binge eating disorder. Olivia's experience was so compelling and we believe it sheds light on the silence around GLP one drugs and their potential benefits beyond weight loss. Join Georgie as she discusses the implications, potential benefits, and risks of using these medications for binge eating disorder. She also delves into the future of research and the pharmaceutical industry in this space. This episode is a must-listen for anyone curious about the real-life impacts of GLP one drugs on binge eating disorder.For more information, check out these references below:https://www.sciencedirect.com/science/article/pii/S2667368123000268https://www.sciencedirect.com/science/article/abs/pii/S0924977X24000646https://doi.org/10.1016/j.dsx.2020.03.00900:00 Introduction to Olivia's Story01:33 Olivia's Background and Binge Eating Journey05:03 Starting Semaglutide: Initial Experiences09:03 Impact on Mental Health and Relationships18:38 Public Perception and Stigma25:16 Opening Up About Personal Struggles27:42 The Impact of Medication on Binge Eating30:55 Alcohol and Medication Effects33:07 Cognitive Behavioral Therapy and Mental Space38:21 Redefining Life Without Food Noise40:44 Final Thoughts and Recommendations46:26 Research and Future Directions for GLP-1 DrugsConnect with Georgie and the Confident Eaters Coaches: WebsiteFacebookInstagramHave you ever thought, "I know what to do, I just need to consistently do it"? Who hasn't? Sometimes we need accountability. Sometimes we need specific strategies, new tools, or a bit of help. If you are want help to become a confident, sensible eater with 1:1 personalized attention, sign up at ConfidentEaters.com.