Podcasts about semaglutide

How to Use Artificial Intelligence for Investing - Combo of 5 ebookshttps://shorturl.at/gM97lGet ready for today's market breakdown! In this video, we cover the top headlines affecting the Indian stock market (BSE, NSE) on October 30, 2025, and analyze the major Q2 FY26 earnings.Major Stock Action:Vodafone Idea (Vi) shares tanked 11% today due to renewed uncertainty surrounding AGR dues after the SC's written order limited the scope of reconsideration. Dr Reddy's stock dropped nearly 6% following a non-compliance notice regarding its Semaglutide injection in Canada.Tech & AI Highlights:Reliance Jio users are set for a major boost with 18 months of free Google AI Pro access (worth ₹35,100), aiming to democratize AI tools in India. Meanwhile, Swiggy announced ₹10,000 Cr in fundraising alongside widened Q2 losses, despite strong Instamart growth.Q2 Earnings Review:We provide key insights from Q2 FY26 results, including:- Hyundai India: Net Profit up 14%.- Lodha Developers: Profit surges 87%.- ITC, NTPC, Adani Power, Cipla, and Pidilite.Global & Macro:The US announced significant reductions in China tariffs, canceling the planned 100% duty. Also, India's gold demand declined 16% in Q3 due to rising prices. Stay updated on all the market trends and investment opportunities!

In this episode, hosts Diana Isaacs, PharmD, and Natalie Bellini, DNP, meet in person at the Diabetes Technology Meeting (DTM) in San Francisco to discuss the latest clinical and regulatory advances surrounding semaglutide. Key Episode Timestamps 00:00:01 Introduction 00:00:42 Oral semaglutide's FDA approval 00:02:02 The SOUL trial and Rybelsus's cardiovascular indication 00:03:35 Dosing for Rybelsus 00:06:18 The SELECT trial 00:08:29 Can GLP-1s be cardiovascular treatments? 00:14:08 Outro

Today, we're exploring the latest updates on Ozempic, a medication that's gained widespread attention for its role in weight loss. Originally approved for type 2 diabetes, Ozempic has shown significant potential in reducing body weight as a side effect. Its active ingredient, semaglutide, works by mimicking a natural hormone called glucagon-like peptide-1, which helps regulate blood sugar and appetite.Ozempic can lead to an average weight loss of about 7% of body weight over several months. However, not everyone experiences this benefit, as results can vary based on individual factors like diet and overall health. Semaglutide is also used in Wegovy, which is specifically approved for weight management and offers a higher dose.Beyond weight loss, semaglutide has been found to have cardiovascular benefits, reducing the risk of heart attacks and strokes regardless of the amount of weight lost. This suggests that its effects extend beyond just weight management.Thank you for tuning in. Be sure to subscribe for more updates on Ozempic and other health topics. This has been a Quiet Please production, for more check out Quiet Please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Olympian & 3x Classic Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 - Intro01:26 - Starting Chat and Merch Talk10:35 - Early Training & First Competition20:32 - Post-Show Binge & Taco Bell Story27:07 - Dessert Obsession & Mukbang Talks33:17 - Low Libido in Prep & Recent Wins36:12 - Dealing with Losses & Growth Mindset40:24 - Embracing Suffering & Process48:23 - Lessons from Last Season & Positivity54:17 - Pressure, Stability & Financial Struggles56:01 - Vegas Trip & First Flights1:03:07 - Travel Strategies & Pro Lifestyle1:12:18 - Hardships, Inspiration & Adversity1:16:12 - Competing Against Daniel & Stage Reality1:18:59 - Tanning & Glaze Lessons1:25:16 - Backstage Anxiety & Timing Errors1:31:08 - Pump Timing & Anxiety in Prep1:46:55 - Classic Division Surprise & Point System1:52:54 - Passion for Competing & Vegas Vibes01:55:07 - Post-Show Health & Growth Strategy2:02:09 - Progress Pics & Cycle Breakdown2:07:20 - Low Dose Philosophy & Longevity2:10:28 - Lab Work & Supplement Insights2:31:09 - Posing Flow State & Stage Confidence2:34:52 - Prep Reduces Anxiety & Staying Ready02:39:38 - Gut Health & Peak Week Tactics2:44:31 - Back Weakness & Training Fixes2:48:15 - Olympia Predictions & Expo Stage Chat3:00:39 - Final Show Reflections & Lessons3:03:29 - Olympia Hype & Vegas Linkup Plans03:04:26 - Control What Matters & Gratitude3:05:24 - Clothing Deals & Meeting Appreciation3:06:29 - Transparency & Meaningful Impact3:07:09 - Vegas, Brownies & Farewell

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Today we're talking about peptides being researched for addiction. We'll unpack the science behind the incretin system, how those pathways tie into reward and substance use, and focus in on the newest triple‐agonist retatrutide. We'll also look at early evidence for alcohol, tobacco and other substance-use disorders when using certain peptide therapies. If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. https://pepties.com/partners/ What are GLP-1, GIP and the “dual/triple” agonists? First, let's review some biology to ground the discussion. GLP-1 (glucagon‐like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) are incretin hormones. Incretins are gut hormones that help with digestion and blood sugar control. They're released by the gut in response to food.  GLP-1 raises insulin levels after you eat to help lower blood sugar, slows gastric emptying, and reduces appetite. It also reduces how much glucagon your body makes. This helps to lower your blood sugar. Medications like semaglutide and dulaglutide work by mimicking GLP-1 and are often referred to as “GLP-1 agonists”. GIP has somewhat overlapping but distinct roles from GLP-1. It too, influences insulin secretion, but it also helps with fat metabolism.  In a nut shell, GIP helps fat cells respond more efficiently to insulin so they release stored fat to be used as energy when your body needs it. This process helps your metabolism shift from just storing energy to burning fat for fuel. Medications like tirzepatide work by mimicking both GLP-1 and GIP and are often referred to as “dual” agonists.  When GIP and GLP-1 are activated together — like in tirzepatide — they work as a team: GLP-1 helps control appetite and slow down digestion. GIP boosts how your body handles insulin and energy. Together, they help reduce hunger, improve metabolism, and burn fat more efficiently. Now here's where it gets a bit tricky.  A newer medication that's still in development, retatrutide, works on three hormone pathways: GLP-1, GIP, and glucagon receptors. It's called a “triple agonist”, and even though it activates the glucagon receptor, it doesn't cause high blood sugar like you might expect. It's about balance. In type 2 diabetes and obesity, the body's hormone signals are out of balance. Retatrutide gently activates the glucagon receptor, but at the same time it strongly activates GLP-1 and GIP receptors — which still help control blood sugar and increase insulin. So blood sugar stays stable or even improves overall. Glucagon doesn't just affect blood sugar — it also increases metabolism and helps the body burn fat and calories. By slightly stimulating glucagon receptors, retatrutide can boost energy use and promote fat loss without causing big spikes in blood sugar. As a result, you get the blood sugar control of GLP-1 and GIP, plus the fat-burning benefits of glucagon activation — leading to even greater weight loss and metabolic improvement.  Right now, retatrutide is in phase 3 clinical trials, which are the final stage of testing before approval. These studies are expected to finish in early 2026, and if results look good, the FDA could approve retatrutide as early as 2027.  Addiction Why is this relevant for addiction? Because the gut-brain axis, reward circuitry, and the pathways that regulate “wanting/consuming” food overlap with those involved in substance use.  Appetite, reward, and craving may share neural substrates (dopamine, GABA, mesolimbic system) and so a drug that reduces drive to eat might also modulate drive to drink, smoke or use other substances. The link between GLP-1/related drugs and substance use disorders  Let's now dive into what the research says about GLP-1 receptor agonists (and related medications) in the context of alcohol, tobacco, and other substances. Let's start with what we know from animal research. In pre-clinical studies, scientists have found that GLP-1 receptor agonists seem to change how animals respond to addictive substances. A systematic review showed that in rodents, treatment with GLP-1 drugs reduced the behavioral effects of alcohol, nicotine, amphetamine, and cocaine. For example, one GLP-1 drug called exendin-4 reduced alcohol-related behaviors in rodents. And even more recently, a study in both male and female rats showed that giving semaglutide, tirzepatide, or even retatrutide, reduced alcohol discrimination, meaning the rats didn't experience the same “feeling” from alcohol as before. This means that the “interoceptive stimulus effects” or the internal sensations — how alcohol feels inside the body, changed. This is really important because this is what often drives people to drink or relapse. So, if these medications can blunt those internal cues, it suggests they might disrupt the rewarding effects of alcohol that help maintain addiction. When we shift to human studies, things get even more interesting. A systemic review found that out of five studies looking at GLP-1 receptor agonists in people with substance use disorders — mostly alcohol and nicotine — three showed real reductions in substance use, while two did not. In one large observational study of over 150 adults with obesity who drank alcohol, those who were taking semaglutide or tirzepatide for at least 30 days reported fewer drinks, fewer binge episodes, and lower overall intake compared to people not on those drugs. A phase 2 clinical trial of once-weekly semaglutide in adults with alcohol use disorder showed similar results — lower alcohol craving and some reductions in drinking behavior. There's also data from a massive registry-based study showing that people with alcohol or opioid use disorder who were prescribed GLP-1 or GIP drugs had 50% lower rates of alcohol intoxication and a 40% lower rate of opioid overdose. Still, experts are cautious — meta-analyses and reviews consistently note that the evidence, while promising, is still early and we don't yet have large, long-term randomized controlled trials. What's Going On? So, what's actually happening inside the brain and body that could explain these changes in craving and reward? How can medications originally made for diabetes and/or weight loss end up helping with addiction?” Mechanistically, GLP-1 drugs may affect the brain's reward system — especially dopamine signaling in areas like the nucleus accumbens — and reduce the “wanting” of reward substances like food or alcohol. They might also calm stress responses and make relapse cues less powerful. And there are probably some physical effects too — things like slower digestion and increased fullness, which might make it harder to physically consume large amounts of alcohol or even smoke as much. But again, many of these findings come from animal models, which don't always perfectly reflect human addiction. Most of the focus so far has been on alcohol, though there's also some early evidence that GLP-1 drugs might influence nicotine use. For substances like opioids or cocaine, the data is thinner and more mixed. Bottom line — at this stage, GLP-1 receptor agonists, and maybe even GIP/GLP-1 dual agonists, represent a really promising new direction for treating addiction — but it's still early days. We also don't yet have human addiction studies on retatrutide, pre-clinical data in rats show that, like semaglutide and tirzepatide, it too, reduces alcohol discrimination. In practical terms, if you're treating patients with obesity or diabetes who also struggle with alcohol or nicotine use, choosing a GLP-1 or dual agonist might offer an unexpected bonus — helping with cravings. It also gives us a new way to talk with patients about how metabolism, reward, and craving are all interconnected. But — and this is important — the data are still limited. Most studies are small, short, and often focus on people with obesity or metabolic disease rather than pure addiction. So, for now, it's an adjunctive idea, not a replacement for established therapies. We'll need larger randomized trials in people with substance use disorders to really understand who benefits, what doses work, and how long the effects last. Thanks for listening to The Peptide Podcast. If today's episode resonated, share it with a friend, please share this episode! Until next time, be well, and as always, have a happy, healthy week.

Leyla Muedin, a registered dietitian nutritionist, discusses the gastrointestinal (GI) side effects commonly experienced by patients using GLP-1 medications such as Ozempic and Rybelsus. Leyla introduces a nutraceutical called Digexin, created by N-X-T-U-S-A, which has shown promise in mitigating these side effects and improving overall well-being. The episode highlights the need for patients to prioritize animal protein intake and incorporate strength training to maintain muscle mass, especially when taking GLP-1 medications. Leyla emphasizes the importance of developing healthy habits and lifestyle changes to sustain weight loss after discontinuing these drugs.

Label changes for tranexamic acid; new approval for Tezspire; psychedelic gains Breakthrough Tx for depression; oral semaglutide approved to reduce MACE risk in T2DM; Gazyva approved for lupus.

Olympian in 212 and now Classic.  @thedurrah  The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro03:19 - Carb Up & Diuretics08:45 - Lineup Drama & Feedback15:19 - Full vs Dry Debate20:58 - Bloodwork Wins & Health Markers25:43 - Water Retention & Dosing40:32 - Schedule Stress & Experience Edge50:06 - 212 vs Classic Prep57:48 - Surgery Loss to Suicide Shift01:03:48 - Quick Q&A & Peak Strategies01:06:26 - Future Moves & Olympia Cycle01:11:39 - Rebound Tips & Self-Coaching01:13:37 - Fatherhood Paradox & Olympia Path1:17:46 - Peace Out

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we're diving into some of the most significant shifts occurring in these industries, touching on strategic restructuring, regulatory milestones, and groundbreaking scientific advancements that are shaping the future of drug development and patient care.Let's begin with a major corporate shakeup at Novo Nordisk. The company has announced a significant leadership transition as former CEO Lars Rebien Sorensen is set to become the new chairman of the board. This change follows the resignation of seven board members and indicates a strategic realignment within the company. The Novo Foundation's involvement suggests a deeper strategic shift, potentially aligning with new organizational objectives and innovations. Such moves are pivotal as they could influence Novo Nordisk's market position and future product development.Turning to scientific breakthroughs, Merck's collaboration with Kelun-Biotech has yielded promising results with their Trop2 antibody-drug conjugate, sacituzumab-tmt. This ADC has shown success in two Phase 3 trials targeting lung and breast cancers, underscoring the therapeutic potential of ADCs in oncology. By selectively targeting cancer cells while minimizing damage to healthy tissues, ADCs could significantly improve patient outcomes and represent a powerful modality in cancer treatment.In regulatory affairs, Kenvue is challenging the FDA over proposed safety warnings for Tylenol linked to autism during pregnancy. This dispute highlights the ongoing debates surrounding drug safety and regulatory oversight. The outcome could have significant implications for labeling practices and consumer trust in over-the-counter medications. Meanwhile, Summit Therapeutics plans to file for FDA approval of ivonescimab, highlighting ongoing innovation in drug development pipelines. Similarly, Novo Nordisk's semaglutide pill Rybelsus has received FDA expansion approval to reduce major adverse cardiovascular events. This sets a new benchmark for oral metabolism drugs by demonstrating their potential beyond glycemic control to positively impact cardiovascular health.As we explore industry trends, there's growing interest in direct-to-consumer drug sales. While this approach offers patients access to medications at reduced costs, it raises concerns about privacy and the quality of care without traditional healthcare provider interactions. Additionally, a notable decline in pharmaceutical TV ad spending by 19% in Q3 suggests a shift towards digital engagement strategies. Amidst these narratives, the Biotechnology Innovation Organization (BIO) has launched an awareness campaign to combat misinformation about vaccines. This effort underscores the importance of immunizations in public health and aims to reinforce trust amid rising disinformation.In another scientific advancement, GSK has released positive Phase 3 data for Spero Therapeutics' oral antibiotic candidate. The oral formulation's efficacy comparable to intravenous options could lead to broader use and improved patient adherence—critical advancements as antibiotic resistance remains a global health challenge.Investment activities reflect strategic shifts within the industry as well. Curewell Capital's investment in Wilmington PharmaTech aims to enhance U.S. active pharmaceutical ingredient production capacity—a crucial step given recent global supply chain disruptions. Similarly, India's ACG is making a $200 million investment in its first U.S. empty-capsule production facility, highlighting the strategic importance of manufacturing capabilities on American soil.Galapagos' decision to wind down its cell therapy unit marks a significant strategic pivot from its previous focus on this modality. This shift reflects broader industry trends where companies reassess priorSupport the show

Hitting a metabolic wall in midlife? You're not alone — and you're not broken. In this episode, Michele Folan, midlife health coach and former diabetes industry insider, breaks down the science (and the truth) behind microdosed GLP-1 and peptide therapy for women 40+.Drawing on many years in diabetes and cardiovascular health, Michele explains how incretin hormones like GLP-1 and GIP regulate appetite, satiety, and insulin sensitivity — and why they've become game-changers for both metabolic and weight health. You'll hear:The wild origin story of GLP-1 (hint: it starts with the Gila monster)Why early GLP-1 drugs revolutionized diabetes careHow microdosing protocols now support fat loss while protecting lean muscleThe real goals: improved A1C, fasting insulin, lipids, inflammation, and energyThis isn't about shortcuts — it's about layering science-backed tools onto strong habits: ✅ Lifting heavy ✅ Eating enough protein ✅ Prioritizing recovery ✅ Partnering with trusted, physician-led telehealth and vetted compounding pharmaciesMichele also dives into other longevity peptides that support sleep, recovery, cognition, skin, and hair health — plus the role of NAD+ in cellular repair and energy.If you've been “doing everything right” and still feel stuck, this episode connects the dots between modern peptide therapy and midlife metabolism — with zero hype and total transparency.

✨ The GLP-1 Circle Membership is opening the doors soon, available for all GLP-1 users, it's your hub for dietitian/personal trainer support on your GLP-1 journey for only $99/month. Get first dibs on membership spots here: Join the waitlist

Send us a textWelcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent phase 2 trial looking at the effects of once-weekly semaglutide on alcohol consumption and craving in adults with alcohol use disorder (AUD). Here we go!Once-Weekly Semaglutide in Adults With Alcohol Use Disorder (0:00 – 10:28).Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog WHAT YOU WILL LEARN: How to SCULPT YOUR MUSCLES AND TIGHTEN YOUR SKIN after weight loss! How to decrease VISCERAL FAT A new way to IMPROVE MUSCLE MASS by 30% for strength and beauty in 4 weeks DECREASE SUBCUTANEOUS FAT by 25% in 4 weekly treatments INCREASE MUSCLE DEFINITION with Emsculpt Neo A way to REHABILITATE AFTER SURGERY PRE-TREAT BEFORE SURGERY: Improve your post op joint surgery condition by increasing muscle around the joint HOW TO RECOVER Quickly AFTER CHILDBIRTH A Way to IMPROVE CORE AND PELVIC FLOOR STRENGTH How EM-Sculpt-Neo works Most of you know me as the expert in Bioidentical Hormone Pellet Replacement, but I am also expert in Skin and body care.  If my patients have problems that your PCP has not been able to solve.  I will refer you for new therapies, cutting edge treatments that work to treat your problem. The most common problem that my patients complain of is loss of muscle mass and changes in body fat that make them look old.  I found a treatment that is not a laser, but the Emsculpt Neo uses safe and effective magnetic energy plus RF treatment to reduce fat and build muscle in a 30-minute painless treatment. Today I am going to talk about a painless treatment that we offer at my medical spa, BioBalance® Skin that has just been approved by the FDA for rehab after joint surgery.  The magnetic energy (HIFEM) combined with RF energy increases muscle size and strength by 30%, dissolve fat by 25%, as well as tightens skin with the same treatment! EM Sculpt Neo is a 30-minute treatment that uses magnetic energy to make your muscles contract and is equal to thousands of crunches for 30 minutes. The RF portion breaks down subcutaneous fat in the same area.  There is no work on your part, you just lie there, and your muscles respond to the magnetic pull by increasing in size and strength.  Four sessions one week apart is the ideal number of treatments, and they come a in a package of four treatments to one area. The areas that most of us want to build muscle and lose fat in are our abs, upper arms, thighs, calves, love handles, and hips. If you need to do more than one area at a treatment you can do up to three areas, each for 30 minutes. If you have had joint surgery and need to increase your strength around that joint, EMSculpt Neo is very effective, after your doctor releases you to exercise. One of the big concerns with the new weight loss medications is that people often lose muscle as they lose weight.  This is especially common after age 40, in those people who are not on testosterone pellets. EMSculpt Neo adds a tool that can preserve or even increase muscle mass and decrease fat where you want to lose it. EMSculpt Neo for fat loss and muscle building (not for rehabilitation) should be saved for those weight loss patients who lose enough weight to achieve a BMI under 30. For the best results, we suggest a high protein low carb diet, protein, low carb diet, to give your body the building blocks for muscle tissue. We also will suggest supplements for nutrition and to abstain from alcohol to get the best results. Healthy fat loss takes combination of EMSCULPT NEO, Weight Loss Medication, activity, Low carb high protein diet.  We advise our patients over BMI of 30 to get started on weight loss first and continue diet medications while you are receiving EM-Sculpt Neo treatments. How do you lose weight without losing muscle? The Best Combination for the best results while you are losing weight on medication: EMSCULPT NEO to the areas you want to remove fat from Semaglutide or Tirzepatide medication to treat obesity for weight loss Testosterone Pellets if you are a woman over 40, and man over 50. Regular exercise like walking High protein diet Supplements to improve your ability to make muscle Who should do this EMSCULPT treatment? People who are working out but cannot do sit ups because of back injury Those folks who want fast muscle mass increase in specific areas Anyone who is on a weight loss program who is losing muscle and fat, or who has saggy skin in areas where they lost weight Patients anticipating a joint surgery Patients healing from joint surgery after PT Patients who cannot lift weights because of injury Those people who lift weights but cannot develop definition People with a Beer Belly with a lot of visceral fat Some people may not be able to enjoy this sculpting, muscle building method: We will do a free consultation before you sign up for a package of EMSculpt Neo and some patients will not get optimal results if they have any of the factors below: BMI greater than 30 Metal implants anywhere that are not titanium. Titanium is not magnetic, so it is ok to have a treatment if you have a titanium joint implant. No Rods or pins. Any pacemaker implant, pain pump under your skin, nerve stimulator or you are in the first 6 weeks post-surgery for any muscle area in the area. If you have a large abdominal hernia that was not repaired, then abdominal treatment is not advisable. You can still have other areas treated. If you have unrepaired joint damage, you can still have this treatment but let us know so we can slowly work the energy up around that joint. Those people who have a pannus, an apron of skin that hangs down below the vulva, or penis will not get enough relief from this procedure. These patients will need an abdominoplasty. This surgery is done by a plastic surgeon who removes excess skin and fat and repairs the muscles and fascia. You should not waste your money if you continue to drink alcohol while undergoing this treatment. Alcohol is a toxin and will prevent the growth of muscle and loss of body fat. Don't waste your money if you are not going to follow a low carb high protein diet during and after our treatment.  How does EMSCULPT Work? EMSCULPT combines HIFEM (High Intensity Focused Electromagnetic technology) and RF (Radio Frequency). HIFEM uses magnetic energy to contract muscles in a particular area at intensities that are not achievable with routine weightlifting. Fat tissue in the treated area is also reduced by increasing metabolic activity.  This results in Body Contouring. HIFEM is approved by the FDA for Body contouring, muscle stimulation, growth and to rehabilitate patients with injuries or after surgery. The second treatment that occurs at the same time as HIFEM is RF, Radio Frequency treatment. RF is a low frequency electromagnetic wave that heats up fat in 4 minutes to stimulate collagen and elastin to tighten skin. All this happens in 30 minutes with minimal discomfort.  4 treatments, one a month, is all that is needed to increase muscle 25% and to decrease fat by 30%, and to visibly improve skin tone. Answers to questions about this procedure: What should my diet consist of to optimize my treatment? To gain muscle you must eat your weight in pounds equivalent to grams of protein every day. E.g. If you weigh 200 lbs. and you want to gain muscle, you should eat 200 grams of protein a day. What foods should I eat to optimize my treatment? The best most concentrated protein is found in animal products-eggs, milk products, fish, chicken and red meat. What supplements will help support my treatment? You may want to supplement your diet with our BioBalance Magnesium combination twice a day, Probiotics, Creatine or Arginine and Ornithine combination. You should also take a methyl B12 and Methyl Folate while you are sculpting your body. Why can't I eat a lot of carbs and drink alcohol during or after the treatment? If you eat a high carb diet, your fat loss portion of Em-Sculpt will be limited, because whatever carb you eat over-stimulates insulin, which increases insulin resistance, and increases fat deposition. Whatever is eaten goes directly to fat again and replaces what you just lost. When can I start EMSculpt after joint surgery? After PT is completed or your surgeon releases you for exercise. Can I lift weights while I am being treated? Yes, but we advise not to lift weights the day before, the day of or the day after your EMSCULPT treatment. What does hydration have to be optimal for the treatment to work effectively? The human body is almost all water, and hydration is needed for muscle contraction. Muscles don't contract optimally when you are dehydrated. We put you on a body composition machine to both document your muscle mass and fat mass, as well as tell if you are hydrated adequately. Now that you know how EMSculpt Neo can change your body composition and build muscle, I hope you are comfortable enough to let us help you get the body you have always wanted. BioBalance Skin phone for an appointment:

Are you always thinking about food, feeling hungry, or never fully satisfied in perimenopause? You're not alone. In this episode, Claudia breaks down why food noise gets louder in midlife, the role of fluctuating hormones, and how nutrition, movement, and even how GLP-1s can help you finally feel in control.  You'll learn: How estrogen fluctuations and blood sugar dips drive constant hunger Why under-eating over 40 backfires The impact of activity level and strength training on fueling needs The role of progesterone and testosterone in appetite  How GLP-1 medications quiet food noise - and why I don't dismiss them Are you hungry for something more in midlife?   Links Mentioned Ep. 78: Undereating After 40: The #1 Habit Wrecking Your Hormones & Metabolism The Effect of Carbohydrate Intake on Strength and Resistance Training Protein Intake to Support Muscle Mass    >    LOVE THE SHOW? Please subscribe, leave a 5-star rating, review, and share with other women, so they can get the support they need in perimenopause!    CONNECT WITH CLAUDIA:  Website YouTube Instagram Facebook Inquiries   FREE RESOURCES:  Mini Training: Why You're Exhausted, Moody & Inflamed - And Why It's Not Just Your Hormones Peri-What?! The Must-Have Guide for Women 40+ Navigating Hormone Changes Perimenopause Daily Checklist HRT 3-Day Crash Course   GET SUPPORT:  Perimenopause Clarity Session The Perimenopause Method Program Perimenopause HRT Roadmap Course   PRODUCTS WE LOVE: Equip Prime Protein (Save 15% w/ code: healthcoachclaudia) Microbiome Labs Total Gut Restoration (Save 15% w/ code: claudia123) BodyHealth Reds Powder Symphony Natural Health Melatonin Glow Below Vaginal Estrogen or DHEA For more products we recommend, click HERE.

Evidence-Based Olympian IFBB Coach of pros like Jordan Hutchinson & Host of IFBB AMAThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro00:04:00 - Value of Transparency & Gear Evolution00:09:24 - Genetics and Drug Strategies00:14:10 - Post-Surgery Growth & Gear Myths00:19:30 - Smart Training & Rebound Management00:26:50 - TRT, Recovery & Tissue Retention00:32:40 - Parasympathetic Recovery & Sleep Struggles00:37:20 - Individualized Training & Overtraining Risks00:43:50 - Smart vs Hard Training Myths00:48:24 - Chest & Leg Training Insights00:52:30 - Jordan's Olympia Prep & Peaking Strategy01:00:00 - Stress-Free Prep & Weight Management01:05:15 - Sleep Hacks & HRT Checkups01:09:04 - James' Prep & Fullness vs Condition01:15:20 - Fruit, Food & Force-Feeding Myths01:22:00 - Gear Balance & Client Collaboration01:26:20 - Retatrutide & New Drug Cautions01:29:29 - Fat Loss Stories & Microdosing01:33:15 - Prep Catastrophes & Client Communication01:38:08 - Offseason & Reverse Diet Strategies01:51:28 - Post-Show & GH Timing Tips02:01:10 - Sugar Timing & Glycemic Control02:06:54 - Stage Experiences & Confidence02:12:11 - Carb Cycling02:24:41 - How Chris Started with James 02:34:10 - Chest Support Pads Restricting Stretch02:38:46 - Final Question

Welcome to Ozempic Weightloss Unlocked, the podcast that brings you the latest updates on Ozempic and its growing impact on medicine, health, and lifestyle. I'm your host, and today, we're diving into what's new, what's raising eyebrows, and what may lie ahead for this game-changing drug.Ozempic, also known as semaglutide, was originally developed by Novo Nordisk for the treatment of type two diabetes. Its ability to mimic a hormone called GLP-1 means it helps regulate blood sugar and, as a side effect notable in clinical trials, leads to significant weight loss. The higher-dose version, Wegovy, was later approved specifically for weight management in people who are overweight or living with obesity. According to the European Association for the Study of Obesity, semaglutide and its cousin tirzepatide are now recommended as first-choice treatments for obesity and related complications. This positions these medications at the forefront of modern obesity therapy, even among patients without diabetes.Recently, there has been a surge in the use of GLP-1 drugs like Ozempic among individuals undergoing bariatric surgery. A study presented at the American College of Surgeons Clinical Congress highlighted that in just four years, the number of patients prescribed these medications before surgery jumped from less than two percent to nearly thirty percent. This reflects a major shift in how we approach weight management and preoperative care. More and more, doctors consider these drugs as integral tools not just for diabetes, but also for weight-related conditions in broader populations.The popularity of Ozempic isn't without concern. The Journal of the American Medical Association published findings showing that people taking semaglutide were twice as likely to develop a form of vision loss called neovascular age-related macular degeneration. Researchers from the University of Toronto highlighted that the risk remains relatively small but is real enough for both patients and doctors to take seriously, especially since the biological mechanism makes sense. Semaglutide can affect blood vessels and inflammation—two factors thought to play a role in this kind of vision loss.Other side effects are drawing attention as well. Studies confirm that up to forty percent of the weight lost on semaglutide actually comes from muscle, including the heart muscle—not just fat. The University of Alberta reports that pairing the medication with ketone supplements preserves muscle mass while still achieving fat loss. This could be an avenue for making Ozempic safer, especially for those worried about long-term effects on strength, immunity, and heart health.The list of reported complications is growing. Aside from the more publicized risks of stomach paralysis and vision loss, there is new evidence that Ozempic may increase hair loss, particularly in women. The United States Food and Drug Administration also updated Ozempic's label to include warnings about severe pancreatitis and kidney injuries, underscoring the importance of careful monitoring and open communication with healthcare providers.A major story this year is just how many patients struggle with these side effects. A new study found that most people who start Ozempic discontinue it within a year. High costs, unpredictable insurance coverage, and complications ranging from discomfort to life-threatening injuries are cited as reasons. Lawsuits against Novo Nordisk for insufficient warning of these risks are mounting, and scrutiny from regulators and the courts is escalating.On a positive note, shortages of Ozempic that plagued pharmacies since 2022 appear to be resolved. The Food and Drug Administration removed the drug from its shortage list this year after confirming an increase in production and availability.Exciting research also points to the future—oral versions of GLP-1 drugs are in development, and clinical trials suggest they may offer effective weight loss without the need for injections. Scientists believe these pills could make treatment easier and more accessible for millions more people.As Ozempic's story grows, one thing is clear: both its benefits and risks need to be part of every conversation between patients and their doctors. As always, it's important for anyone considering or currently using Ozempic to stay informed and to consult their healthcare team about new research, risks, and the best individualized plan.Thanks for tuning in to Ozempic Weightloss Unlocked. Be sure to subscribe for the latest updates on this evolving landscape. This has been a quiet please production, for more check out quiet please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

2x Mr. Olympia Runner-Up, 2x Arnold Classic Champ, USAF Veteren, one of the greatest posers of this era & potentially of all time, and one of the top contenders for the Classic Mr. Olympia title in 1 weekThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 Intro2:19 Breathing Fixes in Prep4:29 Coaching Shift & Gym Updates00:07:13 Pricing Real Talk00:08:19 Success Mindset 16:01 Olympia Plans & Prize Money Talk 18:38 Mr Olympia Beyond Bodybuilding00:21:46 Weider Influence & Sport Growth 27:05 Stage Setup & Judge Analysis 31:46 Jose's Improvements 36:59 Years Left in the Sport 41:42 NY Pro Peak 45:52 Carb Boost Strategy 49:43 Dehydration Fatigue 55:15 Rhomboid Focus 1:02:04 RPG Love 01:07:29 Friend Support 01:15:53 Olympia Packing Insight 1:25:33 Training Priority 1:34:05 Life Purpose Beyond BB 01:38:15 Legacy Building 01:45:03 Hair Transplant & Aesthetic Shift 01:54:21 Transformation 02:05:00 Final Message

GLP-1 medications like semaglutide and tirzepatide — better known as Ozempic, Wegovy, and Mounjaro — are transforming lives through significant weight loss. But along with the health benefits, many patients notice unexpected changes in their appearance: facial hollowing, skin laxity, and body deflation, often referred to as “Ozempic face.”   In this episode of The Aesthetic Doctor Podcast, Dr. Judith Borger explores how GLP-1s affect both the face and body — and what can be done to support our weight loss patients through these changes. Whether you're a a patient curious about safe, effective ways to restore balance and confidence or a provider looking to expand your toolkit of non-surgical treatment, this conversation offers practical strategies, safety insights, and compassionate guidance for navigating the GLP-1 journey.   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Recorded live at Leverage Fitness, so please excuse the background noise.                        Hear what we have to say about: Longevity - Lifespan vs Healthspan Taking a look inside - why getting more extensive bloodwork is vital Weight Loss simplified - calories in vs calories out Medications, Prescriptions and Dietary Aids - deciding which might be best for you Nutrtion - do you have to eat healthy to be healthy? Supplements - which are the most important to consider? Sleep - how does it affect weight, energy and recovery? Taking control when feeling overwhelmed  Gym myths     APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com

PhDc endo & expert on bodybuilding pharmacology & enhanced bodybuilding scienceWatch it: https://www.youtube.com/watch?v=LXErTWYFxBM&lc=Ugyh4j4EKOMWMx7bCDd4AaABAg.ANg5e8KTLa5ANgOVCTnFlCThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 Intro00:04:06 Book Updates & GH Research00:08:55 GH, DHT & Acromegaly00:13:29 GLP-1 & Offseason Nutrition00:18:10 Classic vs Open Bodybuilding00:24:31 Leg Growth & Fiber Types00:28:41 Time Off Gear & Recovery00:34:49 Training Frequency & Volume00:41:18 Prep Cycles & Orals00:46:48 Diet & Fullness Strategies00:49:36 Moving & Compound Reactions00:51:32 GI Health & Peptides00:55:49 Cardio & Skin Thickness01:03:05 Sleep Solutions & Aids01:10:32 Choline & Cognitive Health01:12:20 Surgery Recovery & Female HGH01:18:17 Blood Pressure & Hematocrit01:25:10 Cardio, Fat Loss & Yohimbine01:33:08 Favorite Bodybuilders & GH Dosing01:39:43 GH Injecting best practices01:43:53 Final Message to the world

Dr. Jerry Haas, director of our weight management program, is back with an update on the Signature Skinny Shot. After nearly two years, he and patient coordinator Lauren have fine-tuned the program with monthly check-ins, dose adjustments, and ongoing support.Dr. Haas explains how GLP-1 medications work and clears up TikTok myths with real medical data. He shares the benefits he's seen in our patients so far, from better energy and healthier blood sugar levels to being able to enjoy exercise again.He also talks about what happens once you start hitting your goals, like how to protect your muscle mass, when to shift to a maintenance dose, and what it looks like to eventually come off the medication while maintaining a healthy lifestyle.This isn't a quick fix or a magic wand, but with the right guidance, it's a powerful tool to help you feel healthier, stronger, and more in control of your weight than ever before. Find out the perks of getting your weight loss meds through a plastic surgery center instead of your primary care doctor.LinksLearn more about the Signature Skinny Shot prescription weight loss programsGet to know San Diego skinny shot director Dr. Gerald HaasLearn from the talented plastic surgeons inside La Jolla Cosmetic Surgery Centre, the 12x winner of the San Diego's Best Union-Tribune Readers Poll, global winner of the 2020 MyFaceMyBody Best Cosmetic/Plastic Surgery Practice, and the 2025 winner of Best Cosmetic Surgery Group in San Diego Magazine's Best of San Diego Awards.Join hostess Monique Ramsey as she takes you inside LJCSC, where dreams become real. Featuring the unique expertise of San Diego's most loved plastic surgeons, this podcast covers the latest trends in aesthetic surgery, including breast augmentation, breast implant removal, tummy tuck, mommy makeover, labiaplasty, facelifts and rhinoplasty.La Jolla Cosmetic Surgery Centre is located just off the I-5 San Diego Freeway at 9850 Genesee Ave, Suite 130 in the Ximed building on the Scripps Memorial Hospital campus.To learn more, go to LJCSC.com or follow the team on Instagram @LJCSCWatch the LJCSC Dream Team on YouTube @LaJollaCosmeticSurgeryCentreThe La Jolla Cosmetic Surgery Podcast is a production of The Axis: theaxis.io Theme music: Busy People, SOOP

Diabetes is a condition in which the body cannot regulate blood sugar properly. There are different types of diabetes, each with unique causes and treatment needs. Type 1 diabetes usually occurs in children or young people when the pancreas stops producing insulin completely, making lifelong insulin injections necessary. Type 2 diabetes, more common in adults but increasingly seen in children, occurs when insulin is produced but does not work effectively due to insulin resistance. It may initially be controlled through diet, exercise, and tablets, but many patients eventually require insulin. Gestational diabetes typically develops during pregnancy and often disappears after delivery, yet both the mother and child remain at higher risk of developing diabetes later. Secondary diabetes can occur due to pancreatic infections, steroid use, alcohol, or chronic pancreatitis etc. Another form, known as NODAT (New Onset Diabetes After Transplant), has also been identified. Malnutrition-related diabetes (Type 5) arises when poor maternal nutrition during pregnancy prevents proper development of the child's pancreas, leading to early beta cell failure in adult life. A condition called “double diabetes” is also seen when children with Type 1 diabetes develop the features of Type 2 due to obesity. Diagnosis for Type 1DM often involves a C-peptide test, which measures how much insulin the body is still making. Importantly, early and strict sugar control provides lasting benefits, known as the Legacy Effect and Good Glycemic Memory, helping prevent complications of the kidney, heart, eyes, nerves, and other organs in subsequent years of life. Good glucose control also keeps mitochondria healthy, ensuring better long-term health. In addition, new GLP-1 analogs such as Tirzepatide and Semaglutide have shown benefits for weight reduction and organ protection, though they should only be taken under medical guidance. Expert- Dr Sunil Gupta Anchor- Mrs. Purva Kulkarni Podcast: 13/06/2025 Recorded at: Akashwani Nagpur Episode: 77

Welcome to The Peptide Podcast. In this episode, we're unpacking the latest on retatrutide and how it measures up against semaglutide and tirzepatide.  If you want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  https://pepties.com/partners/ We'll look closely at what the studies tell us so far — from overall weight loss to reductions in visceral fat and how much lean muscle mass is preserved. We'll also talk about where the evidence is solid, where it's still developing, and why cross-trial comparisons should be made with caution. What is retatrutide? So let's start with the basics—what is retatrutide? Retatrutide is a new type of weight-loss medication called a triple agonist. That sounds fancy, but what it really means is that it targets three hormone receptors in the gut and pancreas: GLP-1, GIP, and glucagon. Each of these plays a slightly different role in metabolism and appetite regulation. To break it down: GLP-1, which you might already know from drugs like semaglutide, mainly slows digestion, helps you feel full, and improves insulin sensitivity. GIP, which tirzepatide targets along with GLP-1, also helps regulate blood sugar and may improve how the body stores and burns fat. Retatrutide adds glucagon receptor activation on top of that, which seems to further boost fat burning. So how does this compare to semaglutide and tirzepatide? Semaglutide is a GLP-1-only drug, so it mainly works by reducing appetite and slowing gastric emptying. Tirzepatide is a dual agonist, hitting GLP-1 and GIP, which gives it a slightly stronger effect on blood sugar control and fat metabolism compared to semaglutide. Retatrutide goes one step further by adding glucagon activity, potentially giving more total fat loss. In other words, you can think of it like a spectrum: semaglutide hits one target, tirzepatide hits two, and retatrutide hits three—each additional receptor seems to enhance metabolic effects and fat loss in clinical trials. That's why people are excited about retatrutide, though it's still early, and we're waiting on larger studies to see exactly how it compares head-to-head with the others. And that's going to be key, since right now we don't have direct comparisons to other advanced therapies like semaglutide or tirzepatide in the published Phase 2 data. How does retatrutide compare to semaglutide and tirzepatide? Total body weight loss: Now let's put these three medications side by side and look at what the trials actually tell us about total body weight loss. Starting with retatrutide: in its Phase 2 obesity program, the numbers were unusually large, especially given the relatively short trial window. In the 48-week study, people on the higher doses—8 or 12 milligrams weekly—lost about 22 to 24% of their body weight on average. That's the result that really made headlines. It's worth noting that some trials report slightly different averages depending on the group studied—people with obesity but no diabetes versus people with type 2 diabetes—but across the board, that 48-week signal is consistently very strong. For comparison, let's step back to semaglutide at the 2.4 mg dose, which was tested in the pivotal STEP-1 trial. Over 68 weeks, participants lost about 15% of their body weight on average. That was a landmark finding when it was published in the New England Journal of Medicine—it essentially set the modern benchmark for what a GLP-1 monotherapy could do. Then we have tirzepatide, the dual GIP and GLP-1 agonist. The SURMOUNT-1 trial, which ran for 72 weeks, showed dose-dependent results: about 15% weight loss at 5 mg, 19.5% at 10 mg, and 20.9% at 15 mg, compared to only around 3% with placebo. Other obesity studies with tirzepatide have backed this up, especially at the higher doses. And in head-to-head comparisons with semaglutide, tirzepatide has consistently come out on top. So if we zoom out: retatrutide's Phase 2 data suggest the greatest average reductions—over 22%—in less than a year. Tirzepatide follows closely behind with around 21% over 72 weeks. And semaglutide shows very meaningful, but smaller, weight loss of around 15% over a similar time frame. The big caveat here is that these aren't perfect apples-to-apples comparisons. The trials differed in their length, the types of patients enrolled—some had type 2 diabetes, some did not—their baseline weights, and even the way results were reported. Plus, retatrutide is still in Phase 2 for obesity, whereas semaglutide and tirzepatide already have large Phase 3 programs and real-world data backing them up. Visceral fat reduction: Next, let's talk about visceral fat reduction—that's the deep fat that surrounds organs like the liver, pancreas, and intestines. It's particularly important because high levels of visceral fat are strongly linked to cardiometabolic disease. Starting with retatrutide, one of the Phase 2 substudies used DEXA scans to measure body composition in detail. At the higher doses—8 and 12 milligrams per week—participants saw visceral fat drop by about 29 to 31% over 48 weeks. That's a very large relative reduction in under a year and one of the reasons people are excited about retatrutide's potential not just for weight loss, but also for improving long-term metabolic health. How does that compare to the other drugs? With semaglutide, we also have DEXA and imaging substudies from the STEP program and follow-up mechanistic work. These consistently show meaningful visceral fat reductions, along with improvements in the ratio of lean to fat mass. The difference is that semaglutide studies typically report VAT changes as “significant and clinically relevant,” but they don't always publish one clear headline number that's directly comparable to retatrutide's ~30%. In other words, semaglutide definitely lowers visceral fat, but depending on the study and population, the exact percentage looks different. For tirzepatide, we also have imaging-based data from the SURMOUNT trials and related body-composition studies. These show that the majority of weight lost is fat mass—including a significant portion of visceral fat. Some analyses report reductions on par with what's seen with GLP-1 therapies, while others suggest tirzepatide may push a bit further. But again, the actual percentages vary depending on whether the study used DEXA, CT, or MRI, and on who was enrolled. The big caveat here is that we don't yet have a head-to-head imaging study comparing all three drugs in the same population with the same methods. Retatrutide's ~30% visceral fat drop is certainly eye-catching, but without that kind of standardized comparison, it's hard to say definitively whether it's truly better than semaglutide or tirzepatide. Lean muscle mass preservation: Now let's shift to lean mass preservation, which is just as important as total weight or fat loss. Across all of the modern obesity drug trials, one thing has been consistent: most of the weight people lose is fat, but some lean tissue is lost too. That's expected whenever you're in a sustained calorie deficit. The question is how much muscle is preserved, and how the proportions break down. With retatrutide, the DEXA substudy showed something reassuring. Even though people lost a lot of total weight and fat, the proportion of lean mass lost compared to total weight loss was similar to what we see with other therapies. In other words, the drug seems to drive large fat reductions without causing disproportionate muscle loss. Interestingly, the absolute amount of lean tissue lost in kilograms was pretty stable across different doses, even though fat loss varied quite a bit. That suggests the extra weight loss with higher doses is really coming from fat, not muscle. Looking at semaglutide, the STEP trials with DEXA scans reported the same general pattern. People lost more fat than lean mass, and when you adjust for the total weight loss, body composition actually improved. In fact, some analyses showed a slight increase in the percentage of body weight that was lean tissue, even though the absolute lean mass in kilograms went down. So again, it's not that muscle isn't affected—it is—but fat loss makes up the majority of the change. For tirzepatide, the SURMOUNT body-composition studies found that about 75% of the weight lost is fat and about 25% is lean mass. That split is very similar to what was seen in the placebo groups, which means the drug isn't shifting the balance unfavorably. It preferentially reduces fat, while lean mass preservation is in the same ballpark as semaglutide and retatrutide. Now, here's the important nuance: lean mass on a DEXA scan isn't just skeletal muscle. It includes water, organ tissue, and other components. So if someone loses 3 or 4 kilograms of “lean mass,” we don't know how much of that is functional muscle versus water or smaller organ size. That's why these numbers can be misleading if you take them at face value. And this is where lifestyle comes in. Resistance training and adequate protein intake are critical alongside medication. Lifting weights or doing bodyweight resistance work helps preserve functional muscle, while getting enough protein—typically somewhere in the range of 0.8 to 1 gram per pound per day depending on age and activity—supports muscle repair and maintenance. Every trial we've seen shows that the best outcomes, in terms of maintaining strength and function, come from pairing these drugs with exercise and nutrition strategies. That way, the unavoidable lean mass changes have far less impact on long-term metabolic health and performance. Limitations, biases, and what's missing (the critical context). No large, peer-reviewed head-to-head trials (yet) comparing retatrutide with semaglutide or tirzepatide for the same endpoints using identical imaging protocols. Most comparisons are cross-trial and therefore imperfect. Retatrutide Phase-2 was often compared to placebo or dulaglutide (in the T2D DEXA substudy) rather than to semaglutide or tirzepatide. A head-to-head (planned/registered) study vs tirzepatide is listed on ClinicalTrials.gov but results are not published yet. Different populations & durations. Some retatrutide data come from cohorts that include people with T2D or NAFLD; semaglutide STEP trials were often in people with obesity (without diabetes) and run longer (68 weeks), while tirzepatide SURMOUNT trials ran to 72 weeks. These differences change the absolute and percent outcomes. Funding and reporting bias. Many of the early retatrutide analyses are industry-funded (Eli Lilly), which is standard for drug development, but it requires us to carefully read methods, endpoints, and completeness of reporting. Independent replication and Phase-3 confirmation matter. Imaging method variation. VAT reported by DXA vs MRI vs CT are not directly interchangeable. Some trials report VAT area, others percent change; that complicates cross-trial percent comparisons.  Thanks for listening to The Peptide Podcast. If today's episode resonated, share it with a friend. Until next time, be well, and as always, have a happy, healthy week.

September is Cholesterol Education Month. In this episode of Intelligent Medicine, Jim LaValle, a clinical pharmacist and certified clinical nutritionist, details cholesterol's importance and its implications for cardiovascular health. He delves into the nuances of cholesterol types, the historical shifts in perceptions of cholesterol, and how dietary and lifestyle factors influence cholesterol levels and cardiovascular risk. Jim provides expert insights into the roles of LDL and HDL cholesterol, the significance of cholesterol particle size, the impact of carbohydrates on cholesterol, and the benefits of aged garlic extract and other supplements. The conversation emphasizes the importance of comprehensive lipid testing, understanding individual risk factors, and integrating both lifestyle modifications and, when necessary, medications into cardiovascular preventive strategies. The episode concludes with a discussion on the role of health policies and the future of integrative health approaches.

Dr. Hoffman continues his conversation with Jim LaValle, a clinical pharmacist and certified clinical nutritionist, detailing cholesterol's importance and its implications for cardiovascular health. 

In this episode of the Ageless Future Podcast, Regan Archibald sits down with Dr. Tyna Moore, a bold voice in regenerative medicine, to explore the promise and pitfalls of GLP-1 peptides. Known for her controversial stance on individualized, low-dose prescribing, Dr. Moore challenges conventional medicine's one-size-fits-all approach, advocating instead for “slow and low” dosing tailored to each patient's biology. The conversation covers why GLP-1s are more than just weight-loss tools, their potential in cardiovascular, brain, and metabolic health, and the importance of foundational practices like strength training, gut health, and movement. Dr. Moore also shares her personal journey through chronic illness, the limitations of traditional medicine, and her vision for a future where patients are empowered with optimized, personalized care.Website: www.drtyna.com Info: www.drtyna.com/ozempicuncovered LIKE/FOLLOW/SUBSCRIBE DR. TYNAInstagram: https://www.instagram.com/drtynaYouTube: https://youtube.com/@drtynaPodcast: https://podcasts.apple.com/us/podcast/the-dr-tyna-show/id1577258582

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-451 Overview: The obesity epidemic has fueled a demand for weight loss medications. Trials have directly compared medications—specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—with a recent study doing just that. Tune in as we explore the evidence comparing semaglutide and tirzepatide for weight loss outcomes up to 1 year. Episode resource links: Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. 2024;184(9):1056-1064.  Moiz A, Filion KB, Toutounchi H, et al. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials. Ann Intern Med. 2025;178(2):199-217.  Wen J, Syed B, Nadora D, et al. Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies. Endocrinol Diabetes Metab. 2025;8(3):e70045.  Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-451 Overview: The obesity epidemic has fueled a demand for weight loss medications. Trials have directly compared medications—specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—with a recent study doing just that. Tune in as we explore the evidence comparing semaglutide and tirzepatide for weight loss outcomes up to 1 year. Episode resource links: Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. 2024;184(9):1056-1064.  Moiz A, Filion KB, Toutounchi H, et al. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials. Ann Intern Med. 2025;178(2):199-217.  Wen J, Syed B, Nadora D, et al. Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies. Endocrinol Diabetes Metab. 2025;8(3):e70045.  Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Join Drs. Neil Skolnik and Sara Wettergreen as they answer one of the most common questions people living with diabetes have: “What diabetes medication is best for me?”   In this episode, they'll explore how choosing the right medication depends on your individual health, lifestyle, and goals. Discover practical tips to better help you work with your care team to make informed decisions and find the best treatment plan for you.   Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health, Abington, PA Sara Wettergreen, PharmD, BCACP, BC-ADM, Assistant Professor, Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences; and Ambulatory Care Clinical Pharmacist, UCHealth Lone Tree Primary Care, Aurora, CO Do you have questions or comments you'd like to share with Neil and Sara? Leave a message at (703) 755-7288. Thank you for listening, and don't forget to “follow” Diabetes Day by Day!   Diabetes Medications: Biguanides Brand: Glucophage, Fortamet, Glumetza Generic: Metformin, Metformin XR Sulfonylureas (Second Generation) Brand: Glucotrol, Amaryl, Diaβeta, Glynase Generic: Glipizide, Glipizide XL, Glimepiride, Glyburide Thiazolidinediones (TZDs) Brand: Actos, Avandia Generic: Pioglitazone, Rosiglitazone (no longer available) DPP-4 Inhibitors Brand: Januvia, Onglyza, Tradjenta, Nesina Generic: Sitagliptin, Saxagliptin, Linagliptin, Alogliptin SGLT2 Inhibitors Brand: Invokana, Farxiga, Jardiance, Steglatro, Brenzavvy Generic: Canagliflozin, Dapagliflozin, Empagliflozin, Ertugliflozin, Bexagliflozin GLP-1 Receptor Agonists Brand: Victoza, Trulicity, Ozempic, Rybelsus, Mounjaro (dual GIP/GLP-1) Generic: Liraglutide, Dulaglutide, Semaglutide, Tirzepatide Insulins (selected examples) Brand: Humalog, NovoLog, Apidra, Lantus, Basaglar, Levemir, Tresiba, Humulin N, Novolin N, Humulin R, Novolin R Generic: Insulin lispro, Insulin aspart, Insulin glulisine, Insulin glargine, Insulin detemir, Insulin degludec, NPH insulin, Regular insulin

In parts 1 and 2 we looked at studies that sought to determine the effects of semaglutide on kidney function. Today, in the final part of the series, we are going to discuss another such study called Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes by Perkovic et al., 2024. Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

En este episodio hablo con el Dr. Javier Muñoz sobre la hormona GLP-1, más conocida como Ozempic, Semaglutide o Mounjaro. Descubrí qué hay detrás del boom mundial: sus beneficios reales, cómo actúa en el cuerpo y lo que nadie te cuenta.Disclaimer: Este episodio es educativo e informativo. No sustituye la consulta médica.Dale play y compartilo con alguien que también quiera entender de qué se trata todo este boom del GLP-1.Recordá: cuidar tu cuerpo también es honrar el regalo de la vida.

Send us a textWhat if everything you thought you knew about weight loss was wrong? In this powerful conversation, Joey Pinz sits down with Dr. David Plourdé—scientist, author of Solving the Weight Loss Puzzle, and founder of The Plourde Method—to uncover the real science behind lasting fat loss.Dr. Plourdé shares insights from 34 years in the lab, where he studied fat cells, food addiction, and the hidden forces sabotaging our health. From uncovering insidious carbs in everyday foods to exposing the dark side of weight-loss drugs like Ozempic, his revelations will make you rethink nutrition, exercise, and the role of psychology in transformation.✨ Top 3 Highlights:

Sick of trying fad diets that just don't seem to work for you? Find out how to simplify your approach and succeed by learning and applying the principles of weight management.  How to make calories work for you Which proteins are better than others and when to eat protein Preserving lean muscle while losing body fat "Dirty" vs "Clean" diets Including desert and candy during a weight loss journey   APEX RX https://apexrx.net   Jesse Frank https://www.lvrgfit.com jesse.dfrank@gmail.com   Charlie Seltzer https://drseltzerlifestylemedicine.com info@drseltzerweightloss.com

This is part 2 of my series on the research around GLP-1 drugs for supporting kidney function. In part 1 we looked at Long-term kidney outcomes of semaglutide in ob*sity and cardiovascular disease in the SELECT trial, today we'll look at “Semaglutide in patients with overw*ight or ob*sity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial” Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

AI accelerates drug discovery while steroids turn teens into aggressive strangers. Dr. Michael Israetel explores our pharmaceutical crossroads here!Full show notes and resources can be found here: jordanharbinger.com/1209What We Discuss with Michael Israetel:GLP-1 drugs like Tirzepatide offer massive health benefits beyond weight loss — reducing inflammation, improving brain health, and decreasing addiction behaviors, even for people already in good shape.Steroids don't just amplify personality — they specifically amplify masculine traits like aggression and reduce empathy. Starting young can permanently rewire your brain's emotional and social processing.AI is about to revolutionize medicine by testing millions of drug candidates virtually, creating treatments 10x more effective with 10x fewer side effects. We're entering the pharmaceutical iPhone moment.The "only take drugs when sick" mindset worked in the 20th century, but is becoming dangerously outdated — like refusing elevators because you prefer human operators.When your diet plateaus, take a week-long break eating at maintenance. Your stress hormones will drop, body water will flush out, and you'll often look leaner than before.And much more...And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors:Saily: 15% off: saily.com/jordanharbinger, code JORDANHARBINGERDripDrop: 20% off: DripDrop.com, code JORDANLinkedIn Jobs: Post your job for free: linkedin.com/jordanQuince: Free shipping & 365-day returns: quince.com/jordanBetterHelp: 10% off first month: betterhelp.com/jordanSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Shana Hussin, RDN, shares the replay of her recent webinar on GLP-1 — the hormone behind today's most popular weight loss drugs like Ozempic, Wegovy, and Mounjaro. You'll learn: ✔️ What GLP-1 is and how it works in the body ✔️ Natural ways to increase GLP-1 for fewer cravings, better blood sugar, and fat loss ✔️ Lifestyle habits that decrease GLP-1 and fuel insulin resistance ✔️ The truth about GLP-1 medications: cost, side effects, and sustainability ✔️ How to safely transition off GLP-1 drugs by improving natural GLP-1 and gut health ✔️ The research behind Unimate Yerba Mate and Balance Fiber Matrix — and how they support GLP-1 signaling in the Feel Great System ✨ If you've ever wondered whether you really need expensive GLP-1 medications, or if there's a more sustainable, root-cause solution, this episode is for you. Resources & Links:

Special edition of the JAMA Editor's Summary featuring the JAMA Network articles published at the 2025 European Society of Cardiology Congress. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, with JAMA Executive Editor Gregory Curfman, MD, JAMA Senior Editor Philip Greenland, MD, and JAMA Cardiology Editor Robert O. Bonow, MD, MS. Related Content: Remote Screening for Asymptomatic Atrial Fibrillation Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock Helicobacter pylori Screening After Acute Myocardial Infarction Physiology-Guided Complete Revascularization in Older Patients With Myocardial Infarction Fractional Flow Reserve–Guided Complete vs Culprit-Only Revascularization in Non–ST-Elevation Myocardial Infarction and Multivessel Disease Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis Participation of Women in Cardiovascular Trials From 2017 to 2023 Prevalence, Determinants, and Time Trends of Cardiovascular Health in the WHO African Region

Special edition of the JAMA Editor's Summary featuring the JAMA Network articles published at the 2025 European Society of Cardiology Congress. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, with JAMA Executive Editor Gregory Curfman, MD, JAMA Senior Editor Philip Greenland, MD, and JAMA Cardiology Editor Robert O. Bonow, MD, MS. Related Content: Remote Screening for Asymptomatic Atrial Fibrillation Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock Helicobacter pylori Screening After Acute Myocardial Infarction Physiology-Guided Complete Revascularization in Older Patients With Myocardial Infarction Fractional Flow Reserve–Guided Complete vs Culprit-Only Revascularization in Non–ST-Elevation Myocardial Infarction and Multivessel Disease Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis Participation of Women in Cardiovascular Trials From 2017 to 2023 Prevalence, Determinants, and Time Trends of Cardiovascular Health in the WHO African Region

Open Bodybuilding Olympian, 3x IFBB Pro Champion, pro podcaster in the IFBBAMA and can be often seen on Bodybuilding & Bollocks on the Real Bodybuilding Podcast.Watch it: https://youtu.be/gPfRK3HoAAYThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro to James Hollingshead04:40 Early Bodybuilding Journey and Influences09:18 Deep Dive into Nutrition and Longevity19:16 Steroid Use and Its Impact on Career26:14 Mindset and Overcoming Hardships38:00 Health Monitoring and Genetics46:20 Optimizing Training Splits57:46 Balancing Bodybuilding and Mental Health01:07:25 Dealing with Loss and Finding Purpose01:18:56 Favorite Prep Memories01:26:04 Best Peaking Show Memories01:33:27 Truth About Dosages01:45:36 Rep Ranges for Hypertrophy01:51:35 Offseason Strategy: Mass vs Conditioning01:55:24 Fertility While on Cycle01:57:14 Favorite Compounds02:00:02 Appreciating the Whole Physique02:04:23 Views on Lifting Styles02:07:51 Balancing Fatherhood and Bodybuilding02:14:45 Therapy and Travel Insights02:17:56 Final Message to the World

Olivia emailed us sharing her personal journey with Semaglutide, a GLP one receptor agonist, and how it helped her manage binge eating disorder. Olivia's experience was so compelling and we believe it sheds light on the silence around GLP one drugs and their potential benefits beyond weight loss. Join Georgie as she discusses the implications, potential benefits, and risks of using these medications for binge eating disorder. She also delves into the future of research and the pharmaceutical industry in this space. This episode is a must-listen for anyone curious about the real-life impacts of GLP one drugs on binge eating disorder.For more information, check out these references below:https://www.sciencedirect.com/science/article/pii/S2667368123000268https://www.sciencedirect.com/science/article/abs/pii/S0924977X24000646https://doi.org/10.1016/j.dsx.2020.03.00900:00 Introduction to Olivia's Story01:33 Olivia's Background and Binge Eating Journey05:03 Starting Semaglutide: Initial Experiences09:03 Impact on Mental Health and Relationships18:38 Public Perception and Stigma25:16 Opening Up About Personal Struggles27:42 The Impact of Medication on Binge Eating30:55 Alcohol and Medication Effects33:07 Cognitive Behavioral Therapy and Mental Space38:21 Redefining Life Without Food Noise40:44 Final Thoughts and Recommendations46:26 Research and Future Directions for GLP-1 DrugsConnect with Georgie and the Confident Eaters Coaches: WebsiteFacebookInstagramHave you ever thought, "I know what to do, I just need to consistently do it"? Who hasn't? Sometimes we need accountability. Sometimes we need specific strategies, new tools, or a bit of help. If you are want help to become a confident, sensible eater with 1:1 personalized attention, sign up at ConfidentEaters.com.

Markus Hunter IFBB Pro:  ⁨@Markusfit⁩  The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 - Intro5:43 - Social Media Perceptions and TikTok Labels10:00 - Content Creation Struggles and Polarization17:15 - Reasons for Mindset Change20:00 - Constructive Criticism and Impact Stories26:43 - Insane Tren Doses and Variations30:00 - Gear, Genetics, and Growth36:38 - Learning Your Body and Coaching45:56 - Sleep Aids and Health Risks50:00 - Crazy Cycle Stories58:19 - Back Training Revelations59:47 - Men's Physique vs. Open Bodybuilding1:10:00 - Chasing the Pro Card Reality1:20:00 - Pro Card Struggles and Triumphs1:28:20 - Importance of Sex in Relationships01:29:56 - Best Prep Look Without Diuretics1:40:22 - Cycle variations01:49:12 - Biohacking for Optimal Performance01:59:40 - Evolving Training Strategies2:10:00 - Next Pod Plans02:12:38 -Best way to use superdrol02:18:57 - Growth Hormone02:30:46 - Gear Guidance for Newbies02:36:05 - Gut Health2:50:00 - Long Prep Secrets02:57:12 - the final message02:59:26 - Being Self/ Family Centered as Men

[00:00] Intro banter and chaotic energy kicks off the show[02:30] Storytime: Jack breaks a door, hilarity ensues[12:00] Commentary on Ozempic, semaglutide, and weight-loss trends[22:45] Is Nelly Furtado Puerto Rican? Plus pop culture weight changes[30:00] The invention of the "Ozempic Olympics" (listener suggestions welcome)[35:15] Gen X slang deep-dive (what phrases will never die?)[43:00] The Rock and celebs adapting to aging—humorously dissected[49:30] The "America Quiz" — challenging each other's patriot knowledge[01:00:00] Wrap-up, random laughs, and Fred's memorable shout-out #blcpodcast #podcastingforthepeople #funny #podcast #greenvillesc #scpodcast #yeahthatgreenville Listen at: https://americasfavoritepodcast.com Tweet the Show: https://twitter.com/blcworld Follow us on Facebook: https://www.facebook.com/blcpodcast/ Check us out on Instagram: https://www.instagram.com/blcpodcast/ Buy Fred and Allan Beer: https://www.patreon.com/blcworld

Episode Summary: Summer may have been fun, but if your energy, weight, or motivation feel off, you're not alone. This solo episode is your permission slip to stop the extremes and start fresh—with a metabolism reset grounded in balance, not burnout. Shana walks you through why so many women feel worse after summer, and what to do now to feel amazing again—without restrictive dieting or relying on medications like Ozempic, metformin, or statins. If you're feeling puffy, tired, or stuck, this episode will show you how to gently reset your metabolism, support your hormones, and finally feel great again. 

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:02:08 Coaching Men vs Women & Hormone Challenges00:06:55 Discovering Bodybuilding & Early Training Mistakes00:11:26 First Competition & Prep Lessons00:15:39 Diuretics vs Natural Peaking00:21:17 Athlete Examples & Conditioning Standards00:25:37 Precision in Bodybuilding & Coaching Start00:31:50 Success with Physique Athlete & Olympia Journey00:36:00 Meeting & Working with Terrence Ruffin00:44:13 Fullness, Dryness & Peaking Challenges00:49:32 Coach–Athlete Learning Curve & Comparisons00:55:49 Classic Physique: Shape vs Conditioning01:02:42 Defining a Good Coach & Athlete Safety01:08:48 Health Supplements & Blood Work Frequency01:15:10 Downsizing for Classic Physique & Compound Choices01:22:12 Individual Reactions & Instagram Misinformation01:26:56 Food Intolerances & Insulin Sensitivity Tips01:33:55 Blood Pressure & Root Problem Fixes01:34:54 Off-Season Training Focus & Nutrition01:39:48 Intensifiers01:44:36 Coaching Anxiety & Life Perspective Shifts01:51:29 Olympia Wins & Chasing Coaching Legends01:55:25 Tips for Young Self & Helping Athletes02:05:05 Tren in Men's Physique & Side Effect Management02:17:53 Hyacine's Proudest Moment02:20:59 Superior Genetics?02:22:34 Clen Use & Side Effects02:33:52 Dubai Bodybuilding Scene & Gyms02:37:34 Dubai Lifestyle & Safety02:42:12 Advice for New Coaches & Mentorship02:46:50 Final Message & Podcast Wrap-Up

TakeawaysThe podcast features Dr. Grant Tinsley, a body composition expert.The discussion revolves around a case series on body composition effects.GLP-1 receptor agonists are a focus of the research.The importance of resistance training in weight loss is emphasized.Patient case studies provide insights into individual experiences.The first patient lost a significant amount of fat mass while preserving lean mass.The second patient achieved remarkable body composition changes in a short time.The third patient showed positive changes over a longer duration.The need for more randomized trials is highlighted.The conversation underscores the role of exercise and nutrition in weight management.Tap or Click here to see more from Dr. GrantTap here for scientific references in this episode.

In this episode, Mike discusses the latest GLP-1 craze, which has to do with healthy weight individuals using these medications. ------------------------------------------------Click here to apply for coaching!For some amazing resources and to be a part of a badass community, join our FB group HEREThe personality assessment is now available online! Click here to take the assessment and find out what your personality tells us about the way you should be training and eating.Take the assessment here!To learn more about Neurotyping, visit www.neurotypetraining.comFollow Mike on IG at @coach_mike_millner