Podcasts about Spironolactone

THE LANCET 2003;362:767-771Background: Angiotensin II which plays a role in ventricular remodeling and progression of heart failure can be produced by pathways independent of angiotensin convening enzyme. Preliminary studies showed that the combination of angiotensin II blockers with angiotensin-converting enzyme inhibitors (ACEi) improves hemodynamics and reduces ventricular remodeling.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Added trial sough to assess if adding the angiotensin-receptor blocker (ARB), candesartan, to ACEi could improve outcomes in patients with systolic heart failure.Patients: Eligible patients had left ventricular ejection fraction of 40% or less within the previous 6 months, and NYHA class II, III or IV symptoms. Patients with NYHA class II symptoms had to have cardiac-related hospitalization within 6 months. Patients also had to have treatment with ACEi at a constant dose for at least 30 days.Exclusion criteria were not provided in the main manuscript.Baseline characteristics: Patients were recruited from 618 centers in 26 countries. The trial randomized 2,548 patients – 1,276 randomized to receive candesartan and 1,272 to receive placebo.The average age of patients was 64 years and 79% were men. The average left ventricular ejection fraction was 28%. Cardiomyopathy was ischemic in 62% of the patients. The NYHA class was II in 24% of the patients, III in 73% and IV in 3%.Approximately 48% had hypertension, 30% had diabetes, 56% had prior myocardial infarction, 9% had stroke, 27% had atrial fibrillation and 17% were current smokers.At the time of enrollment, 90% were taking a diuretic, 58% were taking digoxin, 55% were taking beta-blockers, 17% were taking spironolactone and all but two patients were taking ACEi.Procedures: The trial was double-blinded. Patients were assigned in a 1:1 ratio to receive candesartan starting at 4 or 8mg once daily or placebo. The treatment was doubled every two weeks to a target dose of 32mg once daily.After randomization, follow up occurred at 2, 4, and 6 weeks, 6 months and every 4 months thereafter.Endpoints: The primary outcome was a composite of cardiovascular death or heart failure hospitalizations. All deaths were classified as cardiovascular unless there was a clear non-cardiac cause.Analysis was performed based on the intention-to-treat principle. The estimated sample size to have 80% power at 5% alpha was 2,300 patients. The sample size calculation assumed 16% relative risk reduction in the primary outcome with candesartan assuming an 18% annual event rate in the placebo arm.Results: The median follow up time was 41 months. The mean candesartan daily dose was 24mg at 6 months.Candesartan reduced the primary endpoint of cardiovascular death or heart failure hospitalizations (37.9% vs 42.3%, adjusted HR: 0.85, 95% CI: 0.75 – 0.96; p= 0.01). Candesartan reduced the individual components of the primary outcome - (23.7% vs 27.3%; p= 0.021) for cardiovascular death and (24.2% vs 28.0%; p= 0.018) for heart failure hospitalizations. There was no significant reduction in all-cause death (29.5% with candesartan vs 32.4%; p= 0.105). The number of patients who had any hospitalization was similar in both groups (66.8% with candesartan vs 67.5%; p= 0.7), however, the total number of hospitalizations was lower with candesartan (2,462 vs 2,798; p= 0.023).Serum creatinine at least doubled in 7% of the patients in the candesartan group vs 6% in the placebo group. In the subset of patients taking spironolactone, serum creatinine at least double in 11% of the patients taking candesartan compared to 4% of the patients taking placebo.Hyperkalemia, defined as serum potassium of 6 mmol/L or higher, occurred in 3% of the patients in the candesartan group vs 1% in the placebo group. In the subset of patients taking spironolactone, hyperkalemia occurred in 4% of the patients taking candesartan compared to 1% of the patients taking placebo.There were two cases of angioedema in the candesartan group and three in the placebo group. All patients were taking an ACEi.There were no significant subgroup interactions, including in patients taking both beta-blockers and ACEi at baseline.Conclusion: In patients with systolic heart failure, adding candesartan to an ACEi reduced the primary composite outcome of cardiovascular death or heart failure hospitalizations with a number needed to treat of approximately of 23 patients over 41 months of follow up. The total number of all-cause hospitalizations was reduced by 336 with candesartan. All-cause death was not significantly reduced with candesartan.While the results of the trial appear impressive, the high number of adverse outcomes with candesartan in patients taking spironolactone is concerning. Spironolactone led to significant reduction in all-cause mortality in patients with systolic heart failure, as seen in the RALES trial, and should be prioritized over adding candesartan. Notably, fewer than 20% of patients in the trial were on spironolactone at baseline; if more had been, the incremental benefit of candesartan would likely have been reduced due to an increased risk of adverse effects from triple neurohormonal blockade (ACEi, ARBs, and mineralocorticoid receptor antagonists). Furthermore, spironolactone acts by blocking the aldosterone receptor, which is downstream in the renin–angiotensin–aldosterone system. Since candesartan blocks angiotensin II upstream in the same pathway, simultaneous inhibition at multiple points may lead to diminishing benefit.Finally, the differences observed in the subgroup of patients on beta-blockers between this trial and Val-HeFT remain unclear and may simply reflect the play of chance. As we previously discussed, patients receiving both an ACEi and beta-blockers had worse outcomes with valsartan in the Val-HeFT trial.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

Dr. Azi and Nurse Lacie are back with an episode that gets to the root of one of the most talked-about topics in beauty: hair loss. From hormonal imbalances to genetic causes and the latest treatment options, they're breaking down the science behind why we lose hair—and what we can do about it. Together, they answer your most asked questions: How do you know if you're really losing hair? What treatments actually work? Can you support your hair growth with the right ingredients? And what's the deal with PRP, Spironolactone, and Dutasteride? Whether you're dealing with shedding, thinning, or patchy spots, this episode of More Than a Pretty Face is packed with the facts (and a few rapid-fire fun moments, too).   Timeline of what was discussed: 00:00  Introduction 02:25  Beauty & Blemish 08:05  The Most Common Type of Hair Loss 12:57  Ways to Test If You're Going Through Hair Loss 15:39  What Are Some Treatment Options? 21:23  PRP Treatment & Dutasteride Injections 23:51  Taking Spironolactone for Hair Loss 24:29  The Science Behind Hair Growth Cycles 29:48  New Hair Loss Research & Innovations 31:32  Alopecia Areata: What You Should Know 34:23  Rapid Fire Questions   ______________________________________________________________ Submit your questions for the podcast to Dr. Azi on Instagram @morethanaprettyfacepodcast, @skinbydrazi, on YouTube, and TikTok @skinbydrazi. Email morethanaprettyfacepodcast@gmail.com. Shop skincare at https://azimdskincare.com and learn more about the practice at https://www.lajollalaserderm.com/ The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice. © Azadeh Shirazi, MD FAAD.  

This week's topics include treating resistant hypertension, gabapentanoids and the risk of self harm, risk for depression after diagnosis of a medical condition, and fatty liver and pregnancy.Program notes:0:35 Depression after medical condition diagnosis1:36 Any of a number of medical conditions2:37 A much lower risk in comparison group3:37 Major depressive disorder could be number one cause of YLL4:01 Fatty liver and pregnancy outcomes5:01 Matched to those with obesity or T2D6:01 Screening general population not indicated7:00 Gabapentanoids and risk of self harm8:01 Rates of self harm variable 9:04 Use has increased fourfold10:00 Treatment of resistant hypertension11:01 Spironolactone or amiloride12:33 End

N Engl J Med 1999;341:709-717Background: The renin–angiotensin–aldosterone system (RAAS) is activated in patients with systolic heart failure. While this activation initially helps increase blood volume and maintains blood pressure, chronic activation promotes cardiac fibrosis and remodeling. In patients with systolic heart failure, inhibition of the RAAS with angiotensin-converting enzyme inhibitors (ACEi) significantly reduced mortality and morbidity, as seen in the CONSENSUS and SOLVD trials.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Preliminary data suggested that adding the aldosterone-receptor blocker spironolactone to ACEi, reduced the levels of atrial natriuretic peptide and did not lead to serious hyperkalemia.The Randomized Aldactone Evaluation Study (RALES) sought to test the hypothesis that spironolactone would significantly reduce the risk of all-cause death in patients with severe systolic heart failure.Patients: Eligible patients had left ventricular ejection fraction of 35% or less, had NYHA class IV heart failure within the 6 months before enrollment and NYHA class III or IV at the time of enrollment, and were treated with ACEi (if tolerated) and a loop diuretic.Patients were excluded if they had primary operable valvular disease (other than mitral or tricuspid regurgitation), congenital heart disease, unstable angina, primary liver failure, active cancer or any life-threatening condition, other than heart failure, prior heart transplant or awaiting heart transplant, serum creatinine >2.5 mg/dL, or serum potassium > 5.0 mmol/L.Baseline characteristics: Patients were recruited from 195 centers in 15 countries. The trial randomized 1,663 patients – 822 randomized to receive spironolactone and 841 to receive placebo.The average age of patients was 65 years and 73% were men. The average left ventricular ejection fraction was 25%. Cardiomyopathy was ischemic in 55% of the patients and non-ischemic in the rest. The NYHA class was III in 71% of the patients and IV in 29%.Data on baseline comorbid conditions were not provided.At the time of enrollment, 100% were taking loop diuretics, 94% were taking ACEi, 73% were taking digitalis, and 10% were taking beta-blockers. The mean daily dose of ACEi were as following: 63mg for captopril, 15mg for enalapril, and 14mg for lisinopril.Note: Max daily dose is 450mg for captopril, 40mg for enalapril, and 40mg for lisinopril.Procedures: The trial was double-blinded. Patients were assigned in a 1:1 ratio to receive spironolactone 25mg PO daily or placebo.The dose could be increased to 50mg daily after 8 weeks of treatment, If the patient had worsening heart failure and had no evidence of hyperkalemia. In the event of hyperkalemia, the dose could be lowered to 25 mg every other day. Laboratory testing including potassium were performed every 4 weeks for the first 12 weeks, then every 3 months for up to 1 year and every 6 months thereafter until the end of the study.Endpoints: The primary outcome was all-cause death. Secondary end points included death from cardiac causes, hospitalization for cardiac causes and change in the NYHA class.Analysis was performed based on the intention-to-treat principle. The planned sample size was not mentioned in the methods. However, the results mention that recruitment was complete. The sample size calculation assumed 38% mortality rate in the placebo group and that spironolactone would reduce mortality by 17% (relative risk reduction). The power of the study was set at 90% with a two-sided alpha of 5%.Results: Recruitment was complete in Dec, 1996 with follow up planned through Dec, 1999. However, the study was stopped early on Aug, 1998 after interim analysis showed significant reduction in mortality with spironolactone. The mean follow up time was 24 months. After 24 months of follow up, the mean daily dose of spironolactone was 26 mg.Spironolactone reduced all-cause death (35% vs 46%, RR: 0.70, 95% CI: 0.60 - 0.82; p< 0.001). Death from cardiac causes was also reduced with spironolactone (27% vs 37%, RR: 0.69, 95% CI: 0.58 - 0.82; p

Drs Carol H. Wysham and Christopher M. Kramer discuss heart failure and type 2 diabetes, and the role of incretin therapies in the management of HFpEF. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002048. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources The Incidence of Congestive Heart Failure in Type 2 Diabetes: An Update https://pubmed.ncbi.nlm.nih.gov/15277411/ Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease https://pubmed.ncbi.nlm.nih.gov/34601960/ Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America: This statement does not represent an update of the 2017 ACC/AHA/HFSA heart failure guideline update https://pubmed.ncbi.nlm.nih.gov/31167558/ Insulin Resistance and Hyperinsulinaemia in Diabetic Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/26678809/ Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024 https://pubmed.ncbi.nlm.nih.gov/38078592/ The Paradox of Low BNP Levels in Obesity https://pubmed.ncbi.nlm.nih.gov/21523383 Tirzepatide for Heart Failure With Preserved Ejection Fraction and Obesity https://pubmed.ncbi.nlm.nih.gov/39555826/ Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials https://pubmed.ncbi.nlm.nih.gov/35050311/ Beyond Weight Loss: the Emerging Role of Incretin-Based Treatments in Cardiometabolic HFpEF https://pubmed.ncbi.nlm.nih.gov/38294187/ Heart Failure With Preserved Ejection Fraction: Mechanisms and Treatment Strategies https://pubmed.ncbi.nlm.nih.gov/34379445/ Obesity and Heart Failure With Preserved Ejection Fraction: New Insights and Pathophysiological Targets https://pubmed.ncbi.nlm.nih.gov/35880317/ Epidemiology of Heart Failure in Diabetes: A Disease in Disguise https://pubmed.ncbi.nlm.nih.gov/38334818/ Semaglutide in Patients With Heart Failure With Preserved Ejection Fraction and Obesity https://pubmed.ncbi.nlm.nih.gov/37622681/ Mechanisms of Benefits of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Preserved Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/37674356/ Finerenone in Heart Failure With Mildly Reduced or Preserved Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/39225278/ Effects of Tirzepatide on Circulatory Overload and End-Organ Damage in Heart Failure With Preserved Ejection Fraction and Obesity: A Secondary Analysis of the SUMMIT Trial https://pubmed.ncbi.nlm.nih.gov/39551891/ Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, a Preserved Ejection Fraction, and Obesity https://pubmed.ncbi.nlm.nih.gov/39556714/ Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy https://pubmed.ncbi.nlm.nih.gov/39566869/6 Spironolactone for Heart Failure With Preserved Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/24716680/

Struggling with stubborn acne, eczema, psoriasis, or dry, irritated skin—no matter how many creams, medications, or skincare products you've tried? In today's episode, we're breaking down exactly why your skin issues aren't actually about your skin… and why the key to clear, healthy skin starts with healing your gut.We'll cover: ✔️ Why medications like Spironolactone and Accutane don't fix the root cause✔️ How gut imbalances like leaky gut, bacterial overgrowth, and sluggish liver function show up on your skin✔️ Common mistakes (like overusing aggressive topicals) that may be making things worse✔️ The step-by-step approach we use with clients to heal skin issues from the inside out✨ Want to learn exactly how to start healing your skin naturally?Grab your free Skin & Gut Health Guide to learn the WHYs behind your skin issues & what will actually help you overcome them so you can effortlessly have clear, glowing skin! DM me the word “SKIN” on Instagram, and I'll send it straight to you or follow this link to get it right away!

In this bonus episode, we're hanging out with Dr. John Barbieri as he breaks down the FASCE Trial, a major study comparing spironolactone and oral antibiotics for acne treatment. Tune in to hear his insights on the findings, their impact on clinical practice, and what this means for the future of acne management!

In this episode, Dr. Valentin Fuster discusses a study on sodium zirconium cyclosilicate (SZC) for managing hyperkalemia in heart failure patients on mineralocorticoid receptor antagonists (MRAs) like spironolactone. While SZC effectively reduced hyperkalemia and allowed higher spironolactone doses, concerns over worsening heart failure events highlight the complex balance between treatment benefits and risks.

In this episode of To The Root, Robyn Spangler takes a deep dive into Spironolactone—one of the most commonly prescribed medications for hormonal acne. Originally developed to treat high blood pressure, this medication has gained popularity for its ability to reduce androgen-driven acne. But does it address the root cause, or is it merely a temporary solution?Robyn explores the science behind Spironolactone, how it impacts androgen levels, and why it works for some but not others. She also discusses key considerations such as potential rebound breakouts, the role of potassium balance, and what its effectiveness (or lack thereof) can reveal about your underlying skin health. Whether you're currently using Spironolactone, considering it, or looking for long-term solutions, this episode provides essential insights to help you make informed decisions about your skincare journey.Tune in now to gain clarity on Spironolactone's role in acne treatment and explore holistic strategies for lasting skin health!Highlights: Understanding Androgen-Driven Acne: How Spironolactone suppresses androgens and its impact on sebum production.Rebound Effects & Discontinuation: Why acne may return after stopping the medication and how to prevent it.The Role of Potassium: How Spironolactone affects potassium levels and why proper mineral balance is crucial.Assessing Your Acne Type: What it means if Spironolactone worked for you—or didn't—and how that can guide your root cause approach.Long-Term Considerations: Why addressing underlying factors like insulin resistance, stress, and hormonal imbalances is key to sustainable skin health.Connect with Robyn:Instagram: @nutritionbyrobyn Website: https://www.theclearskinlab.com

The CLEAR SYNERGY (OASIS 9) Trial: A 2x2 Factorial Randomized Controlled Trial of Colchicine versus placebo and Spironolactone versus placebo in Patients with Myocardial Infarction.

CLEAR SYNERGY (OASIS 9): A 2x2 Factorial Randomized Controlled Trial of Colchicine Versus Placebo and Spironolactone Versus Placebo in Patients with Myocardial Infarction

In order to create space for growth and alignment...we must shed things that no longer serve us. FIRST THING: Amy reads a special email from a listener, Kristin, who shares an update on her eating disorder. Her story is a powerful reminder of how far we can come when we commit to growth. SECOND THING: Amy's giving facial fitness a go as she takes a break from Botox (because she fears muscle atrophy!!) and she's just working out her face from videos on YouTube. Below are a few that she likes so far. As for Botox, she shares some tips on how to avoid muscle atrophy if you're still getting injections (which she likely will do again one day herself!) 10-Minute Exclusive Face Fitness Practice 5 min massage for changing your face! 10 Minute Face Yoga To Do Each Evening To Lift And Firm The Skin THIRD THING: Amy opens up about her personal decision to stop taking Adderall for ADHD and Spironolactone for her face. Medications like Adderall and Spironolactone have their place and can be highly effective, but it’s essential to evaluate their role in your life continually. FOURTH THING: Amy shares a quote that fits the theme of today's episode. "Shedding is necessary. Letting go of what no longer serves us creates space for growth, for new things to flourish." -Unknown HOST: Amy Brown // RadioAmy.com // @RadioAmySee omnystudio.com/listener for privacy information.

Ep. 157 On today's episode of Pursuit of Wellness, Dr. Tyna Moore, a naturopathic and chiropractic physician with expertise in regenerative medicine, joins us to provide clarity on GLP-1 medications. With a background in metabolic health and chronic pain management, Dr. Tyna explains how GLP-1s can benefit individuals with weight loss goals, PCOS, and insulin resistance. She shares valuable advice on individualizing doses, understanding how these medications interact with insulin and muscle mass, and how to approach conversations with doctors about your dosage. We also cover the risks associated with Ozempic, especially in those dealing with metabolic dysfunction, and discuss how these drugs impact areas like fertility and chronic pain. Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Dr. Tyna's Instagram click here! For Dr. Tyna's Website click here! Sponsored By:  The holidays are closer than ever, so make sure you order by December 16th to get their gift (or yours) underneath the tree in time! Visit Carawayhome.com/POW to take advantage of this limited-time offer for up to 20% off your next purchase. Again that's Carawayhome.com/POW to get new kitchenware before the holidays. Caraway. Non-Toxic cookware made modern. Visit BetterHelp.com/POW today to get 10% off your first month. That's betterhelp.com/POW. Head to Manukora.com/POW to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook! Visit clearstemskincare.com and use code POW at checkout for 20% off your first purchase. Again, that's code POW for 20% off your first purchase on clearstemskincare.com. The Fits Everybody collection is available in sizes XXS to 4X. You can shop now at SKIMS.com. After you place your order, be sure to let them know I sent you! Select "podcast" in the survey and be sure to select my show in the dropdown menu that follows. And if you're looking for the perfect gifts for the whole family - SKIMS just launched their biggest Holiday Shop ever - also available at SKIMS.com.  Show Links: Ozempic Uncovered University   Dr. Tyna's GLP1s Done Right Dr Tyna GLP1 Episodes  Finding A Doctor  Episode Keywords + Tags (YouTube) Health, Wellness, Fitness, Nutrition, Pursuit of Wellness, Dr. Tyna, Semaglutide, Microdosing, Weight Loss, GLP-1, Regenerative Medicine, Metabolic Health, Podcast Host, Peptide, PCOS, Obesity, Fertility, Social Media Influencers, Mucus, Mucinex, TikTok, Cystic Acne, Epigenetic, Infertility, Spironolactone, Androgen, Orthorexia, Peptide, Menstrual Cycle, Anti Inflammatory, Pharmaceuticals, Hormones, Insulin Signaling, Insulin Reception, Insulin Resistant, Metabolic Pathways, Waist Circumference, Skinny Fat, Muscle Mass, Toned, Lean, Arm Sculpting, Crohn's, Microbiome, Ozempic, Muscle Loss, Heroin Chic, Chain Smoking, Metabolic Dysfunction, Dosage, Individualized Dosing, Freedom, Chronic Pain Topics Discussed 00:00:00 - Introduction  00:03:54 - Dr. Tyna's journey 00:06:44 - Initial success stories 00:07:54 - Fertility  00:09:20 - GLP-1's and cystic acne 00:16:22 - PCOS diagnosis 00:21:09 - Low dose GLP-1 benefits 00:29:18 - Who metabolic health applies to 00:31:53 - Pick up the weights! 00:34:41 - GLP-1's and the microbiome 00:37:20 - Ozempic mistakes 00:41:49 - How Ozempic affects the body 00:45:24 - Individualized dosing 00:48:01 - How to talk to your doctor about low dosing 00:52:56 - Cycling do's and don'ts 00:54:05 - Clarity around the different drugs 01:00:01 - GLP-1's and addiction 01:02:46 - Dr. Tyna's Ozempic Done Right University 01:05:45 - Wellness to Dr. Tyna

In this episode of the To The Root Podcast, Robyn Spangler R.D. outlines a practical, evidence-based approach to addressing acne at its root causes. She discusses the five primary contributors to acne—hormones, infections, inflammation, stress, and topical irritants—and explains why restrictive diets and quick-fix solutions often fail to provide lasting results. Robyn also shares insights on how past acne medications like Accutane, antibiotics, or Spironolactone can offer valuable clues about underlying issues. Whether you're managing your own skin concerns or supporting clients in their journey, this episode offers a clear roadmap to natural, sustainable skin healing.For a deeper understanding of skin healing, visit theclearskinlab.com/freecourse  to access Robyn's free two-part video training and a comprehensive mineral guide. Get started on the path to clear skin today.Use the code ROOT at check-out for 10% off Rayvi: https://rayvishop.com/ Highlights:Identifying the five key drivers of acne and their subcategories.Why addressing root causes can eliminate the need for long-term dietary restrictions.How medications reveal patterns in hormonal, inflammatory, or infection-driven acne.The role of testing in uncovering hidden contributors like gut health, mineral depletion, and iron overload.How stress impacts skin health and the importance of improving stress resilience.Connect with Robyn:Instagram: @nutritionbyrobyn Website: https://www.theclearskinlab.com

JACC Associate Editor Michelle M. Kittleson, MD, PhD, FACC, interviews author Mikhail Kosiborod, MD, FACC about his REALIZE-K study published in JACC and presented at AHA. In participants with HFrEF and hyperkalemia, SZC led to large improvements in the percentage of participants with normokalemia while on optimal spironolactone dose, and reduced risk of hyperkalemia and down-titration/discontinuation of spironolactone. More participants had HF events with SZC than placebo; this difference was limited to those with very high NTproBNP levels.

Did you miss AHA 2024? Listen here to brief discussions of the latest research. Eric Rubin is the Editor-in-Chief of the Journal. Jane Leopold is a Deputy Editor of the Journal. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin, J. Leopold, and S. Morrissey. NEJM at AHA — Routine Spironolactone in Acute Myocardial Infarction. N Engl J Med. DOI: 10.1056/NEJMe2414472.

Send us a message with this link, we would love to hear from you. Standard message rates may apply. In this episode of Your Checkup, we dive into simple, effective ways to start managing acne at home. From understanding the importance of cleansing routines to selecting the right over-the-counter treatments, we'll guide you through the basics of skincare that can make a big difference. Tune in to learn how to tackle common triggers like excess oil, clogged pores, and inflammation, while also debunking popular acne myths that could be holding you back from clearer skin. Whether you're dealing with breakouts or want to prevent them, this episode is your starting point! Please find out detailed show notes below Acne BasicsAcne is the most common skin disorder in North America, affecting 85% of teenagers.Pimples form when skin cells block a hair follicle. This is made worse by oil (sebum) production and bacteria on the skin.Acne SeverityAcne can range from mild to moderate to severe.At-home treatments can usually handle mild acne. Moderate and severe acne usually require prescription medications from a primary care doctor or dermatologist.Acne Treatment LayersHygiene: Wash your face no more than two times a day with a gentle, non-soap cleanser and warm water. Don't use washcloths or loofahs.Moisturization: Use a non-comedogenic moisturizer, especially if other treatments dry out your skin.Sun Protection: Protect your skin from the sun with sunscreen (SPF 30 or higher) or protective clothing. Too much sun can worsen acne and age your skin.Over-the-Counter Treatments for Mild AcneTopical Retinoids: Adapalene 0.1% gel is the only topical retinoid available over the counter in the US.Apply a thin layer to the entire affected area (don't spot treat) once a day, usually at night. Start every other night to reduce irritation, working up to every night over a few weeks.Use a pea-sized amount for the entire face and make sure your skin is dry.Don't use with benzoyl peroxide.Benzoyl Peroxide: Comes in cleansers, gels, lotions, creams, pads, masks, and washes. Concentrations range from 2.5% to 10%.Apply once a day.Benzoyl peroxide can bleach fabric and hair.Salicylic Acid: A good alternative if your skin can't tolerate topical retinoids.These treatments may take up to 12 weeks to work.Combination TherapyUsing benzoyl peroxide in the morning and a retinoid at night can be effective.Sometimes topical clindamycin is used with benzoyl peroxide.Treatment for Moderate to Severe AcneFor severe or widespread acne, or acne that's causing scarring, doctors will start systemic therapy right away, instead of waiting to see if topical treatments work.Doxycycline is an antibiotic that reduces inflammation and fights bacteria.Spironolactone is a medication that can help regulate hormones.IsotretinoinImportant NotesDon't pick or squeeze pimples: This can worsen acne and may cause swelling and scarring.Be patient: It can take several weeks for treatments to show results.Talk to a doctor: If you have concerns about your acne or at-home treatments aren't working,Support the showProduction and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Renne: hi dr. cabral! after many years of stubborn acne and not seeing the results from my functional efforts, i reached a point where i was willing to try spironolactone for reducing androgen production. after only 8 days on 50mg, i developed intense right side flank/kidney pain that was also associated with heart flutters. i stopped the meds and everything subsided after 3 or so days. could my low potassium have caused this? any thoughts?   Angie: Thank you for making functional medicine more accessible and affordable to all! I have a few questions…. How do I know what podcast episode to listen to for the answers? I did the two week detox and I still don't feel well. I didn't lose any weight, I was hungry the whole time, my stomach still feels bloated and I am still gassy. What now? Also can you tell me what you think of Truvani's products by the food babe?    Lorie: My right eye waters off and on all day long. Especially in the cold, or when air blows on me. It is not dry eye or a problem with my tear duct being blocked. Is there anything I can do for it? The eye doctors have not been able to help me. This has been going on for at least 15 years. Thank you   Mia: I have been dealing with gut issues for a while and recently developed Mast cell activation syndrome. Could the root cause of MCAS be the gut issues? And, could dealing with that could resolve the MCAS?I keep hearing MCAS is progressive and not curable (and mine is progressively getting worse every few months) and am very scared because the symptoms of MCAS are quite terrible. Is there any suggested testing or tips to dealing with it?   Terri: Hi Dr. Cabral~ Thank you for having the best podcast ANYWHERE and for being so generous with your time and knowledge. I am a 61-year-old woman and have normal, although probably not optimal, thyroid levels. I recently shot up rather suddenly into the 6+ TSH range with really no explanation that I can think of from a dietary or environmental exposure standpoint. My question is… I had a few recent incidences of ingesting an NAC supplement with an inadequate amount of water and the burning in my throat was excruciating and lasted about 15-20 minutes each time. Is it possible that this could have damaged my thyroid and if so, is it reparable? Thanks so much for taking my question!   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3180 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

On this episode of the Real Life Pharmacology Podcast, I cover 5 more medications of the top 200. Fenofibrate is a medication used primarily to reduce triglycerides. This medication differs from statins which tend to focus on LDL management. Doxazosin is an alpha-blocker. The primary indications of doxazosin are hypertension and BPH. Naproxen is an NSAID. Of all the NSAIDs, naproxen is one of the lower-risk agents with regard to cardiovascular risk. Spironolactone is an aldosterone antagonist and also classified as a potassium sparing diuretic. Memantine is an NMDA antagonist that is indicated for the management of Alzheimer's dementia. If you are looking for study materials and our list of popular Amazon books, check out meded101.com/store!

Tired of dealing with acne, whether you're a teenager or an adult? Want to achieve clear, glowing skin naturally with solutions that actually work? This episode is for you. If you're ready to ditch birth control, Spironolactone, harsh topicals, Accutane, and endless rounds of antibiotics, tune in. Our guest, Kayleigh Christina—one of the leading holistic acne experts and co-founder of CLEARSTEM—shares her groundbreaking approach to skincare. With CLEARSTEM, they're shifting the skincare paradigm by addressing acne and aging at the root cause. As a Certified Holistic Nutritionist, Kayleigh struggled with cystic acne in her mid-twenties and finally found lasting clarity through this comprehensive, root-cause method to skin health. In 2017, she and Danielle Gronich, both passionate about holistic wellness, joined forces to create safer, more effective skincare solutions. Today, their work has empowered millions to achieve clear skin for life. To learn more about CLEARSTEM and receive 15% of your first purchase visit www.clearstemskincare.com and use code HEALINGTHESOURCE at checkout.  Follow CLEARSTEM and Kayleigh Christina on Instagram. And don't forget CLEARSTEM's other queen of a founder, Danielle Gronich Follow the host, Claudia Gilani, @healingthesource and check out HealingTheSource.org

On this episode, Dr. Sadaf is joined by dermatologist Dr. Mary Alice Mina to discuss everything you need to know skin care as we age. Dr. Mina is a board-certified dermatologist and during this discussion, she shares her expertise on how our skin changes through different life stages including puberty, pregnancy, perimenopause, and menopause. Find out how and why hormone fluctuations can influence our skin health, why sugar can negatively impact our skin, and the critical role sun protection plays in aiding our skin as we age.Disclaimer: Anything discussed on the show should not be taken as official medical advice. If you have any concerns about your health, please speak to your medical provider. If you have any questions about your religion, please ask your friendly neighborhood religious leader. It's the Muslim Sex Podcast because I just happen to be a Muslim woman who talks about sex.To learn more about Dr. Sadaf's practice and to become a patient visit DrSadaf.comLike and subscribe to our YouTube channel where you can watch all episodes of the podcast!Feel free to leave a review on Apple Podcasts and share the show!Follow us on Social Media...Instagram: DrSadafobgynTikTok: DrSadafobgyn

Send us a Text Message.Grab your trainers, your dog lead or a cuppa and join us for some free CPD as we have another relaxed round up of recent Red Whale primary care Pearls of wisdom.  June was another bumper month information, meaning that we can't possibly squeeze it all into one handy sized episode, so in the first of two episodes this month, Nik and Caroline discuss: Curable: hepatitis C and the NHS elimination programme.Acne: what's new?Listen as soon as you can to ensure you have full access to all the free resources. The rest of the Pearls from June will be covered next week along with a new best intentions story to put a smile on your face.Hep CHEP Drug Interactions (interaction checker for DAAs)If you're interested in becoming a GP champion for Hep C, email:connect.HepCULater@mpft.nhs or england.hepc-enquiries@nhs.netOrder Hep C home testing kit online at: hepctest.nhs.uk AcneThe British Association of Dermatology patient information leaflet for isotretinoinSend us your feedback podcast@redwhale.co.uk or send a voice message Sign up to receive Pearls here. Pearls are available for 3 months from publish date. After this, you can get access them plus 100s more articles when you buy a one-day online course from Red Whale OR sign up to Red Whale Unlimited. Find out more here. Follow us: X, Facebook, Instagram, LinkedInDisclaimer: We make every effort to ensure the information in this podcast is accurate and correct at the date of publication, but it is of necessity of a brief and general nature, and this should not replace your own good clinical judgement, or be regarded as a substitute for taking professional advice in appropriate circumstances. In particular, check drug doses, side-effects and interactions with the British National Formulary. Save insofar as any such liability cannot be excluded at law, we do not accept any liability for loss of any type caused by reliance on the information in this podcast....

Hair loss is a common and troublesome issue affecting millions of Americans. Today we look into the common cause of hair loss and how to improve hair growth, thickness and coverage. Listen to discover: What stages hair goes through as it grows How hormones and hormone replacement affects hair growth Autoimmune conditions that cause hair loss How medical conditions, stress and life changes can cause loss of hair The length of time it takes to regrow hair Over the counter and prescription medications to enhance hair growth How PRP can enhance our hair The benefit of exosomes Using procedures like light therapy and microneedling to avoid surgery Hair transplant options If you're noticing thinning hair or a receding hairline, this is one episode you don't want to miss! Key Moments in this episode are: 01:28 Stages of hair growth 04:35 Androgenic alopecia 05:47 Telogen effluvium 08:21 Alopecia areata 09:18 Other causes of hair loss 11:31 Can hair regrow on its own? 12:01 Simple changes to enhance hair growth 13:52 Minoxidil for hair loss 14:47 Finasteride for hair loss 16:55 Duasteride for hair loss 17:56 Spironolactone for hair loss 19:12: PRP (platelet-rich plasma) for hair loss 20:32 Exosomes for hair loss 24:59 Low level laser therapy for hair loss 27:10 Microneedling for hair loss 28:29 Hair restoration surgeries Learn more about PRP for hair loss here: https://www.foundationsfl.com/prp Discover the power of exosomes for hair restoration here: https://www.foundationsfl.com/derive Understand how Keravive can improve scalp health here: https://www.foundationsfl.com/keravive Follow us! Instagram @foundationskristinjacksonmd Website https://www.foundationsfl.com/ FB facebook.com/advancedurogynecology Loved this episode? Share with a friend.

Dr. Feldman on RESISTANCE TO OTHERS' IDEAS -Mind over matter over wound healing -Intradermal Botox: Just as good or possibly better! -Spironolactone works! ...but not until 6 months -Appropriate use criteria for dermpath studies -Want to donate to the cause? Do so here!Donate to the podcast: uofuhealth.org/dermasphereCheck out our video content on YouTube:www.youtube.com/@dermaspherepodcastand VuMedi!: www.vumedi.com/channel/dermasphere/The University of Utah's DermatologyECHO: ⁠physicians.utah.edu/echo/dermatology-primarycare -⁠ Connect with us!- Web: ⁠dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC- Instagram: dermaspherepodcast- Facebook: www.facebook.com/DermaspherePodcast/- Check out Luke and Michelle's other podcast,SkinCast! ⁠healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out ourfriends at:- ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge)- ⁠www.levelex.com/games/top-derm⁠ (A free dermatology game to learnmore dermatology!

In episode 575, James and Mike invite Jamie Falk back to the podcast to help us sift through all the evidence for using oral contraceptives and spironolactone to treat acne. We find that they actually do work. We go over all the numbers for the benefits and harms. Have a listen. Show notes Tools for […]

In today's episode of "The Food Code" podcast, we're thrilled to have Lindsey Carter, a board-certified nurse practitioner with over 20 years of nursing experience. Lindsey shares her holistic approach to healthcare, emphasizing the importance of treating the root cause rather than just the symptoms. Join us as we dive into various skin health topics and practical advice for maintaining optimal skin health.Tune in to learn:[00:00:00] Introduction and Passion for Root Cause[00:01:47] Comprehensive Approach to Healthcare[00:02:00] Understanding the Constant Changes in Our Bodies[00:09:43] The Importance of Ceramides for Skin Health[00:13:21] The Impact of Diet and Gluten on Skin Health[00:15:00] Effective Topical Treatments for Acne[00:22:01] Understanding the Use and Safety of Spironolactone for Acne[00:27:00] The Importance of Medical-Grade Skincare Products for Optimal Skin Health[00:29:20] The Relationship Between Gut Health and Skin Conditions[00:34:47] Treating Contact Dermatitis: Identifying the Source and Using Topical Steroids[00:42:00] The ABCDEs of Moles: How to Identify Concerning Moles[00:44:48] Managing Skin Tags: When to Seek Treatment[00:48:10] Preventing Skin Irritation and Infection: Avoid Picking at the Skin***Connect with Lindsey:

Hey there! Welcome back to the second part of Acne Meds! Today, we're diving into the world of antibiotics and gut health. We'll chat about our own experiences and the big costs, both in terms of finance and how our bodies feel, in a healthcare system that loves quick fixes and prescriptions. We'll dig into the not-so-fun side effects of antibiotics, like messing up our gut bacteria and how acne can come back after treatment.  We'll mix in some serious thoughts with funny stories, all to remind ourselves why it's important to question our treatments and stand up for what we need. Let's ditch the idea of instant fixes and focus on making lifestyle changes that keep our guts happy. After all, our gut health is connected to everything else going on in our bodies! So, get comfy as we share our own tales of long-term antibiotic use, and remember, it's all about finding that balance between what helps and what hurts. Let's dive in! In this episode, we discuss:High Cost of Healthcare and Gut HealthThe Side Effects of Oral AntibioticsGarlic's Efficacy in Preventing Gastrointestinal IssuesSpironolactone and Antibiotic HerbsChallenges of Western Medicine and Pharmaceutical Use Implications of Continuous Antibiotic Use Show Note Links:  Antibiotics use in Canada: Preserving antibiotics now and in the future Let's ConnectApply to work with us in The Clear Skin Solution here.Download The Gut Loving Cheat Sheet here.Follow Katie on Instagram here. 

Are you ready for a pop quiz and a lot of insights into the complexities of acne treatment? Today, we're exposing truths, debunking myths, and sharing personal stories from our own encounters with acne medications. We unpack the allure and limitations of isotretinoin, a medication once hailed as a 'miracle drug,' detailing its wide range of potential side effects, from dryness to birth defects. Through personal clinical experiences, we discuss the gravity of choices around medication, reminding you that while isotretinoin can target acne causes like excess oil and inflammation, it may not address the root problem.Switching gears, we also explore the multifaceted impact of birth control pills and highlight the importance of understanding bodily responses to hormonal changes. From gut health to mental well-being, we paint a holistic picture of the consequences of birth control and the concept of estrogen dominance, proving that education is pivotal!In this episode, we discuss:Birth Control and Acne MedicationsImportance of Medical SupervisionPersonal Experiences with Birth ControlEstrogen Dominance and CandidaRegulating Detoxification ProcessesTransitioning off Birth ControlAre you ready to embark on a journey of informed health choices? Tune in to this episode for a deep dive into acne medication and birth control, and arm yourself with knowledge. See you next Wednesday for part2, The Impacts of Antibiotics & Spironolactone!Let's ConnectApply to work with us in The Clear Skin Solution, here.Download The Gut Loving Cheat Sheet, here.Follow Katie on Instagram, her 

In today's episode, I, your host Ashlene, am excited to share the inspiring story of Olivia, a woman I had the privilege of working with last year. Olivia's journey highlights the transformative power of relinquishing the struggle to control her health and instead embracing a path of healing. Her experience resonates with many women who grapple with hormonal imbalances, experiencing a sense of chaos and frustration in their health journeys. Olivia's insights provide a fresh perspective on addressing the root cause of PCOS-related hormonal imbalances, offering valuable lessons for anyone navigating similar challenges.Olivia's Struggles:Olivia, 31 years old, grappled with a myriad of symptoms including acne, irregular periods, and mood swings, which greatly impacted her self-esteem and confidence. Despite trying various treatments such as Accutane and Spironolactone, Olivia found herself in a relentless battle against her symptoms, feeling disconnected from her body and trapped in a cycle of despair. Through her healing journey, Olivia began to see her body in a new light and embrace a new mindset toward creating the health she wanted.My hope in this episode is that Olivia's journey reminds you of the importance of approaching health with patience, understanding, and a willingness to listen to the body's signals. Through Olivia's experience, I encourage you to reflect on your mindset towards your health and explore new ways of nurturing your body towards harmony and well-being.You can take the quiz to discover your root cause hereThe full list of Resources & References Mentioned can be found on the Episode webpage at:https://nourishedtohealthy.com/95Let's continue the conversation on Instagram! What did you find helpful in this episode and what follow-up questions do you have?

Acne impacts millions, causing more than just physical symptoms. In a conversation with Dr. John Barbieri, Director of Advanced Acne Therapeutics Clinic at Brigham and Women's Hospital and Assistant Professor at Harvard Medical School, we explore cutting-edge acne treatments. Dr. Barbieri, with his deep insights into Spironolactone, isotretinoin, and the innovative 1726 nanometer laser, Avi Clear, underscores the significance of aligning treatment with patient needs, advocating for shared decision-making in acne management. Please SUBSCRIBE to the Derm Club Podcast wherever you like to listen whether on YouTube, Apple, or Spotify. Together, let's explore the fascinating secrets of dermatology and skincare. Connect with me across Social: Twitter: https://twitter.com/drhankopelman Instagram: https://www.instagram.com/doctor.han/ TikTok: https://www.tiktok.com/@drhankopelman Blog: https://www.hannahkopelman.com/blog/ The content of this podcast is for entertainment and educational purposes only. This content is not meant to be a substitute for medical advice or treatment for any medical condition. --- Send in a voice message: https://podcasters.spotify.com/pod/show/hannah-kopelman/message

Jamie McGuire joins me on this episode to challenge mainstream beauty and health standards! I so admire how outspoken and well-rounded Jamie is when it comes to not just skin health, but overall well-being.  We chat about her journey to how she got to where she is now as an integrative skin AND gut health coach (and why I think those two things should always go hand-in-hand). We discuss why the sun might not be as scary/damaging for us as we've been told, how seed oils can make you burn faster, what the deal is with all those awful acne-targeted medications like Accutane and Spironolactone, is Tretinoin actually a holy grail, should we be washing our faces in the morning, and are lasers in or out?! References: Jamie's Instagram Jamie's Offerings (courses/ebooks) Jamie's Website Clearstem Skincare products (great for acne-prone girlies!) discount code: HEALINGTHESOURCE Follow the host, Claudia @healingthesource  

Autoimmune progesterone dermatitis - Sirolimus for KP rubra - Spironolactone does not cause cancer - Dupi -> Th17/23 issues - Berdazimer for molluscum - Want to donate to the cause? Do so here! http://www.uofuhealth.org/dermasphere Check out our video content on YouTube: https://www.youtube.com/@dermaspherepodcast and VuMedi!: https://www.vumedi.com/channel/dermasphere/ The University of Utah's Dermatology ECHO: ⁠https://physicians.utah.edu/echo/dermatology-primarycare - ⁠ Connect with us! - Web: ⁠https://dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! ⁠https://healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge) - ⁠https://www.levelex.com/games/top-derm⁠ (A free dermatology game to learn more dermatology!)

Hormones, HRT, and the right kind of skincare - plus: Roaccutane (and other meds), in-clinic options, scarring, diet, alternative treatments…this is Dr. Sophie's 101 when it comes to acne.

Joining me this week is my guardian angel, Emily Morrow, an Integrative Health Practitioner and Nutritional Therapy Practitioner. Emily saved me from a life of acne and hormonal imbalances and now she's here to share her wisdom, insights, and candid tales of her own health battles. She taught me the importance of digging deeper, of looking beyond the symptoms to the root cause of our health concerns - a lesson that has transformed my life.We delve into often misunderstood topics like cholesterol, hormones, and diets. We also discuss gut and liver health, an often overlooked aspect, especially in adolescents. We focus on skincare, supplements, and lifestyle changes for acne management, and the significant connection between mental health and acne. Emily shares her knowledge on how to use dietary switches for improved wellness, addressing acne with individualized approaches, and managing stress for overall healthMake sure you listen all the way to the end for some rapid Q & A, where we learn about acne safe makeup, fragrance in candles, deodorants to use, red light therapy, body acne and eczema.Products Mentioned:Organo King CoffeeTherO3 - BubblerClearstemskincare.com and use code POW for 15% off your orderPhospholipid Complex - BodyBioCir-Q Tonic Golden Thread SupremeLiquid Glutathione Morinda SupremeSchisandra SupremeCamu SupremeAshwagandha SupremeGastro DigestBlack Cumin OilSpore PowderIllicium SupremeHigher Dose Sauna BlanketCastor Oil PacksPriia Acne Safe Makeup LineLeave Me a Message - click here!For Mari's Instagram click here!For Pursuit of Wellness Podcast's Instagram click here!For Emily's Website click here! For Emily's Instagram click here!Timestamps2:09 - My skin journey and how I met Emily2:40 - Emily's journey 4:09 - Implications of tonsil surgery 5:31 - Importance of finding the root of your health issues7:03 - Mold toxicity, how it shows itself9:00 - Common issues Emily sees in lab work 11:05 - Can kids take the same supplements as adults?11:36 - Normal is not optimal 15:00 - Cholesterol Myths16:30 - PCOS18:33 - How YOU can find and build your health team and what tests you should be asking for?23:00 - What are common things Emily sees in acne patients lab work24:00 - 4 acne pillars25:15 - What is Spironolactone and Accutane doing to our bodies?27:55 - A look at my bloodwork + the steps I took to heal my acne33:05 - Dairy and skin health 35:00 - Why you don't want to heat your olive oil and what to use instead 36:40 - Coffee to buy, and coffee to avoid 40:13 - Foods to fight mold and parasites47:11 - Potatoes and why they are good for acne50:00 - Supplements Emily had me take to heal my acne + what she had me avoid54:00 - Cassava flour and why some should avoid it55:00 - Lifestyle tips for better skin59:33 - Stress and acne: are they related? 01:01:01 - “Be thankful for your acne because its your body telling you something” 01:06:00 - Food sensitivity tests: are they worth it?01:07:00 - Rapid Fire Q+A: Acne Safe Makeup, Fragrance and Candles, Deodorants to Use, Red Light Therapy, Body Acne, EczemaProducts Mari Mentioned:Organo King CoffeeClearstemskincare.com and use code POW for 15% off your orderProducts Guest Mentioned:Clearstemskincare.com and use code POW for 15% off your orderPria Acne Safe Makeup LineThis episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Control Body Odor ANYWHERE with @lumedeoderant and get $5 off your Starter Pack (that's over 40% off) with promo code POW at lumepodcast.com #lumepodBrought to you by BETTERHELP. Give online therapy a try at betterhelp.com/pow and get on your way to being your best selfUse code POW15 at checkout for 15% off your entire order at www.vionicshoes.comProduced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today on Fertility Forward, we will discuss another research abstract presented at this year's American Society for Reproductive Medicine (ASRM) Conference, titled ‘Spironolactone use in oocyte maturation in patients undergoing oocyte cryopreservation.' Here to join us in conversation about it are two of the authors, who are also endocrinologists at RMA of New York, Dr. Atoosa Ghofranian and Dr. Kimberley Thornton. Tune in now to hear more about Spironolactone and its uses, where their research question stemmed from including the story behind the interest in this project, highlights from the study's findings, and more.  

On this episode, I discuss spironolactone pharmacology, adverse effects, drug interactions and much more. Spironolactone has numerous indications including hypertension, CHF, ascites, and acne. I break them all down in this podcast episode. Hyperkalemia is a major concern with spironolactone. Patients with baseline levels at 5 or above should generally avoid this medication. Gynecomastia is one of the most commonly tested adverse effects of spironolactone. Be sure you don't miss this one on your board and pharmacology exams!

Polycystic ovarian syndrome (PCOS) is a condition that can benefit greatly from diet and lifestyle therapies. In this episode Cody leads us in a discussion about  the best diet for PCOS, which should be part of a your treatment approach to this complex condition.Often, once diagnosed with PCOS the initial treatment options include hormonal birth control, Metformin, and perhaps Spironolactone. While all of these can be beneficial for some women, they aren't often enough in the management of PCOS symptoms. Tune into today's episode to learn how powerful nutrition and lifestyle strategies can be some of the most effective "medicine" for you.Did you learn something new today? Be sure to subscribe to this podcast and share this episode with all the girls you love. We would appreciate it if you'd also leave us a rating and review on iTunes.You can watch full episodes on YouTube now as well. Like and Subscribe to the It's Hertime Podcast HERE!Want to join our Mixhers Girl community and keep this conversation going? We'd love to hear your thoughts, feelings and experiences! Join us HERE!Join Mixhers email list and be the first to have access to new products and be the girl in the know!Follow Cody and Jess on Instagram:@codyjeansanders@jesstoolson@mixhers

September is PCOS Awareness Month! To start off this special month, on my latest Podcast episode, I discuss an essential topic for PCOS management. In this episode, I explore the top 3 prescription medications for PCOS symptom management. Watch the full episode and learn more about each medication's: - benefits -considerations - potential side effects Become empowered with the knowledge you need to make informed decisions about your PCOS treatment. ✨Additional Resources: Save your spot for the⁠⁠⁠ ⁠⁠exclusive community⁠⁠⁠⁠⁠.  Apply for 1:1 Coaching⁠⁠⁠ ⁠⁠here⁠⁠⁠⁠⁠  Get the "How to Enjoy Indian Food Guilt-Free with PCOS" Mini-course⁠⁠⁠ ⁠⁠here⁠⁠⁠⁠⁠ ✨Free Resources: Subscribe to the Newsletter and get “⁠⁠⁠⁠⁠Dr. Ami's Top 3 Vitamins for Conceiving with PCOS” ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠Watch the recorded masterclass:⁠⁠⁠⁠⁠ "Freedom from PCOS Symptoms - Create a Sustainable Lifestyle with PCOS in 5 Steps."  Fill out this form to collaborate with Dr. Ami!⁠⁠⁠ ⁠⁠https://forms.gle/EpTtJKo8eE79r5EB8⁠⁠⁠⁠⁠  Connect with your host Dr. Ami Patel, send a DM and introduce yourself via Instagram & TikTok @PCOS.Holistic.Coach  If you enjoyed this episode, please leave a review. This will help the podcast reach other listeners that need support with their PCOS. Thank you so much!

If you have PCOS or have struggled with acne, you have likely heard your doctor mention Spironolactone. While this medication is intended for hypertension, edema, and heart failure, it is a common pharmaceutical prescribed for PCOS. On today's Friday Chats episode, I'll cover why it's used for PCOS, the potential side effects, and more specifics on requirements for being diagnosed with PCOS. I'm here to empower you to better understand how to make daily decisions that can heal your PCOS naturally! --- Fullscript Supplement Dispensary

If you've been following the show for a while, you may have noticed that we talk a lot about acne, and this is no accident. Adult acne is becoming increasingly more common, and with that, prescriptions for medications designed to treat acne are also on the rise.  It's no surprise that more and more people are turning to medications, like antibiotics, Accutane, and Spironolactone as a solution to clear their skin. In fact, according to the American Osteopathic College of Dermatology, over 2 million people have taken Accutane to date. While these treatments have become commonplace in acne management, they aren't the magic overnight solution they're often made out to be... and in my opinion, should be considered carefully if your doctor has recommended them for you. So in today's episode, we will uncover the truth behind these acne medications, including how they work, why they are a temporary bandaid, and some important side effects you will definitely want to consider. Disclaimer: This information is for educational purposes only and does not take the place of medical advice. These statements are not intended to diagnose, treat, cure, or prevent any disease. You should always consult with a healthcare professional before starting on any health plan or taking supplements.   Podcast Highlights How antibiotics, Accutane, and Spironolactone are used to treat acne Short and long term side effects to consider Can these medications “cure” acne?   Links Mentioned Is a Hormonal Imbalance Causing Your Acne: https://emmediane.com/blogs/skin-tips/is-a-hormonal-imbalance-causing-your-acne  Episode 21: Spotlight on Skin Cancer: A Survivors Story: https://emmediane.com/blogs/skin-theory-podcast/21-spotlight-on-skin-cancer-a-survivors-story  Acne 101 Series: https://emmediane.com/pages/understanding-acne-series    Special Offers Have skin concerns or looking for help building a routine? Work with me directly for FREE: http://emmediane.typeform.com/to/uVuLYeg2#source=skintheory   Sign up for our newsletter for 15% off + expert skincare advice delivered directly to your inbox!  Sign Up: https://emmediane.com/pages/newsletter  

Today on the show we have Candace Marino, aka The LA Facialist, who has been a medical esthetician for over a decade, developing custom complexion protocols and unique techniques for a highly–discerning celebrity clientele. Candace has such a direct, “no-bs” approach to skincare and I love hearing her honest and real takes on what works and what doesn't, the impact of skin issues on overall health, as well as how to overcome individualized skin problems. On this episode, we discuss the connection to skin and inner wellness, the minimal daily must-have routine you need, products that are too harsh, how to heal acne scars, what the skin barrier does, the benefits (or not) of things like: zit stickers, red & blue light, Botox & fillers, Accutane & Spironolactone, AviClear, Sculptra, and more. There are so many specific tips and takeaways here for anyone at any point in their skin journey to benefit from, I hope you enjoy Candace's tips and she was kind enough to provide a discount code sitewide for my listeners below!Discount code is live POW15 for 15% off any order $100+ at www.thelafacialist.comFor Mari's Instagram click here!For Pursuit of Wellness Podcast's Instagram click here!For Canace's Instagram click here!For The La Facialist Website click here!To shop Bloom Nutrition Greens click here! To download Mari's workout plan & recipes click here!Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episodeGo to www.Clearstemskincare.com and use code POW for 15% off your orderGo to www.apolloneuro.com/pursuit and save $40Go to www.butherbox.com/pursuit and use code PURSUIT to claim this deal to get $20 off your first orderGo to www.honeylove.com/POW and save 20% offGo to www.betterhelp.com/POW to get 10% off your first monthProduced by Dear Media See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog. BioBalance Health® pellets are very safe and not painful to have inserted. They are also the easiest form of hormone replacement a woman can have because the dose is adapted every 4 months and our patients only have to think about their hormones three times a year.   BioBalance Pellet therapy is associated with fewer side effects than any other hormone replacement, and we have a 95% success rate for resolving the symptoms of menopause and testosterone loss. Women's lives are drastically impaired at menopause.  BioBalance, and T pellets improve their quality of life to the level of quality they had before they were 40.   Dosage and pellet side effects are specific to the individual and it may take us a few pellet insertions and blood tests to get the ideal result. Finding your perfect fit is like having a custom suit made: hormone balance requires patience and several fittings, before we determine your maintenance dose, which will direct your dose of E/T for follow up pellet insertions.   We give a handout to each patient when she checks out after her first pellet insertion. We ask patients to follow the instructions given to them verbally and in writing in our office. Risks of pellet insertion procedure, risk of taking estradiol and risk of taking testosterone are rare, but patients are given this handout, so they know what to expect.  These same risks are on their consent that they read and sign before they even come to the office the first time.   Here are the most important instructions for immediate care of the insertion site:   ·      Take the pressure dressing off in 3 HOURS ·      Take the steri-strip off in 3 DAYS ·      Don't traumatize your incisional area ·      If you are allergic to tape please tell us ·      For three days don't submerge in water—hot tubs, bathtubs, the lake, a stream, or the ocean. ·      For three days don't exercise ·      Don't take oral or IV steroids if it is not life-threatening   Please tell us if you are on steroids or take blood thinners so we can alter our treatment plan.   The risks of the pellet insertion procedure include:   ·      Infection ·      Bleeding, ·      Bruising ·      Allergic reactions ·      Swelling ·      Pain ·      Reaction to the lidocaine with epinephrine :shakiness and anxiety, lasts a short period of time, and is not permanent.  Tell us if you have this side effect, and we will use lidocaine without epinephrine the next insertion. ·      Keloid scarring     As is usual for medicine , individual patients have a higher risk based on their medical history. Patients who are at higher risk for complications secondary to the pellet insertion procedure in patients who are:   ·      Diabetic ·      Have an autoimmune disease ·      Take steroids ·      Have a clotting/bleeding disorder ·      Keloid former ·      If you have many allergies ·      If you have orthopedic implants that require antibiotics at the dentist, then you should tell us so we can give you antibiotics.     Risks of taking testosterone pellets with BioBalance Health® in the first few weeks or months and are transient. These side effects usually resolve on their own without treatment.    The transient risks of testosterone treatment include:   ·      Over the top sex drive=Hypersexuality ·      Vaginal itching from increased blood flow—it is not an infection ·      Facial hair and acne (Prevented with Spironolactone preventive treatment) ·      Weight gain from muscle mass and sometimes from conversion of testosterone into estrone which is a genetic risk. ·      Increased muscle mass that is confused with weight gain. ·      Lowered voice is only a problem when you are a singer.  Generally, those who think they have a lowered voice really have reflux and it has nothing to do with testosterone pellets. ·      Clitoral enlargement—this is a reaction to a new testosterone exposure, and generally will go away in the following few months. ·      Thinning of hair at the temples and crown (Prevented with Spironolactone preventive treatment)   Women can take testosterone without estrogen before menopause, and after menopause if requested, however the symptoms of menopause will not be completely resolved with testosterone only pellets.   The risks of estradiol pellets are higher for patients with a uterus, than those women who have had a hysterectomy.   Those women with a uterus have the following risks:   • Uterine bleeding, growth of fibroids: Estradiol of any kind - pellets, pills, patches etc. - can stimulate the uterus to bleed. This can come from a thick lining, adenomyosis (spongy uterus), or fibroids. Prescribing progesterone, optimally sub-lingual progesterone or BLA progesterone from Belmar pharmacy, taken 1-2 times a day, counteracts this. Other treatments are surgical and offered by your Gyn. Your doctor will evaluate you for treatments: uterine wall ablation (80% effective), or a Mirena IUD. Sometimes bleeding will necessitate the choice between a hysterectomy and contin   Risks of estradiol pellets for women with and without a uterus: ·      Vaginal discharge: Estradiol increases the moisture in your vagina. This is a gift to some and a curse to others. This wetness is not an infection, but a normal response of the vagina to estradiol. It needs no treatment, but if it bothers you, then the choice might be that you might have to stop getting estradiol of any kind, or just put up with the wetness, or decrease the estradiol dose with the next insertion. ·       Bloating: This is sometimes caused by too high a dose of estradiol for a particular person, or the conversion of estradiol into estrone, which causes water weight gain. Some women need progesterone to balance the estradiol, to treat bloating. Others require a diuretic, or a low carb diet, thyroid medication, DIM supplementation or more exercise. Most of the time this symptom will resolve itself in a few weeks after it starts, as the body balances itself out. Bloating has many non-hormonal causes as well. ·      Anxiety/Depression: Most women's anxiety decreases as estradiol levels rise, but others feel irritable, and for this occurs only in a small subset of the population. For those patients we add progesterone SL (Sublingual tablets) to their regimen, and they improve. Think about whether you stopped your antidepressant when you started pellets. This is a premature move and can cause women to emotionally crash. Please continue your anti-anxiety medications, or your anti-depressants until 4-6 months has passed, and have the prescribing doctor help you wean off. ·       Breast tenderness: This symptom is usually from a hormone called estrone, and not estradiol, but breasts that have not been exposed to estradiol for years sometimes hurt as they “wake-up”. This is generally limited to a month during the first pellet cycle. The product DIM can alleviate this symptom. Remember that stimulation of the breast can also cause them to swell and hurt! In rare patients, progesterone can cause breast tenderness. ·      Weight Gain: Weight gain occurs for many reasons especially over the Holidays. Other times water weight gain can come from Estradiol. This water weight is self-limited and sometimes requires progesterone balancing, a diuretic, or thyroid replacement, increase of protein and decrease of carbohydrates and alcohol. • Migraine headaches: Estradiol in high levels that increase and decrease drastically destabilize the neurotransmitters and can instigate a migraine headache. Pellets increase very slowly, and decrease very slowly, so either your headache is a tension headache and not a migraine, or has a trigger other than estradiol, such as stress, weather change, or food allergies. Migraines generally improve on Estradiol and Testosterone pellets.    

It's another session of CardioNerds Rounds! In these rounds, Dr. Jenna Skowronski (Chief FIT at University of Pittsburgh) and Dr. Natalie Stokes (Formerly FIT at University of Pittsburgh and now General Cardiology Faculty at University of Pittsburgh) join transformational leader, educator and researcher, Dr. Mary Norine Walsh (Director of Heart Failure and Transplantation at Ascension St. Vincent Heart Center and Program Director of AHFT at St. Vincent) to discuss cardio-obstetrics and heart failure cases. Amongst her many accomplishments, Dr. Walsh is past president of the American College of Cardiology, Deputy Editor of JACC Case Reports, and a preeminent voice and thought leader in women's cardiovascular health. Audio editing by CardioNerds academy intern, Pace Wetstein. This episode is supported with unrestricted funding from Zoll LifeVest. A special thank you to Mitzy Applegate and Ivan Chevere for their production skills that help make CardioNerds Rounds such an amazing success. All CardioNerds content is planned, produced, and reviewed solely by CardioNerds. Case details are altered to protect patient health information. CardioNerds Rounds is co-chaired by Dr. Karan Desai and Dr. Natalie Stokes.  CardioNerds Rounds PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Show notes - Cardio-Obstetrics and Heart Failure Case 1 Synopsis: A woman in her earlier 30s, G1P1, with a history significant for peripartum cardiomyopathy presents to clinic for pre-conception counseling.  Her prior pregnancy was in her late 20s with an uneventful pre-natal course and a spontaneous vaginal delivery at 37w2d.  Two weeks after delivery, she experienced symptoms of heart failure and was found to have a new diagnosis of HFrEF. At that time TTE showed LVEF 30-35%, LVIDd 5.1cm (top normal size), diffuse hypokinesis. At that time, she was diuresed and discharged on metoprolol succinate 25mg po daily and furosemide 20mg po daily.  She had one follow up visit 6 months postpartum and the furosemide was discontinued.  Today in your office, she has NYHA Class I symptoms with no signs of symptoms of congestion. She walks daily and does vigorous exercise 1-2 times per week, while remaining on metoprolol.  Repeat TTE with LVEF 45-50% and similar LV size. She would like to have another child and was referred to you for counseling. Case 1 Rounding Pearls: Dr. Walsh discussed extensively the importance of full GDMT in this patient who was initially undertreated with only a beta blocker.  If patients are breastfeeding, clinicians should consider the addition of ACE-Inhibitor and Spironolactone. Otherwise, if not breastfeeding, they should receive maximally tolerated doses of full GDMT. For more details on medical therapy for Heart Failure during pregnancy and after, refer to this previous CardioNerds Episode with Dr. Julie Damp. Patients with peripartum cardiomyopathy are at highest risk of worsening LV systolic function when they have persistent LV systolic dysfunction from their initial diagnosis. In this circumstance, shared decision making is paramount.  These patients should receive counseling on contraception and risk of pregnancy on worsening LV function, death, & fetal demise. In addition, counseling includes discussing with patients limited options in some states for complete, comprehensive reproductive care, including pregnancy termination. If patients with prior peripartum cardiomyopathy do become pregnant, a team-based approach including cardiologists, maternal fetal medicine, and obstetrics (amongst other team members) is essential to determine care & delivery timing/method.  These patients should also be examined for signs of decompensation throughout the pregnancy, including rales, S3 or a reported history of PND.

Exercise, sudden cardiac death in sports, new TAVI data, behavioral psychology, EHR doing good things, maybe, and coffee are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Fitness and Longevity Even Small Changes in Fitness Tied to Lower Mortality Risk https://www.medscape.com/viewarticle/989906 - Changes in Cardiorespiratory Fitness and Survival in Patients With or Without Cardiovascular Disease https://www.jacc.org/doi/full/10.1016/j.jacc.2023.01.027 II. SCD in Sports Sports-Related Sudden Cardiac Arrest 'Extremely' Rare in Women https://www.medscape.com/viewarticle/990025 - Incidence of Cardiac Arrest During Sports Among Women in the European Union https://www.jacc.org/doi/full/10.1016/j.jacc.2023.01.015 - Sex-Related Differences in Sports-Related Sudden Cardiac Death Should Be Reflected in Guideline Screening Recommendations∗   https://www.jacc.org/doi/full/10.1016/j.jacc.2023.01.014 - Association between physical activity and risk of incident arrhythmias in 402 406 individuals: evidence from the UK Biobank cohort https://doi.org/10.1093/eurheartj/ehz897 III. EVOLUT Three Year Data Encouraging 3-Year Data for TAVR in Low-Risk Patients: EVOLUT https://www.medscape.com/viewarticle/989144 - Three-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients with Aortic Stenosis https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017 - Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients https://www.nejm.org/doi/full/10.1056/nejmoa1816885 - Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk https://www.jacc.org/doi/10.1016/j.jacc.2020.12.052 IV. Behavioral Psychology NUDGE-FLU: Electronic 'Nudges' Boost Flu Shot Uptake in Seniors https://www.medscape.com/viewarticle/989108 - The Effect of Electronic Nudges on Influenza Vaccination Rate in Older Adults With Cardiovascular Disease: a Prespecified Analysis of the NUDGE-FLU Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064270 - Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.057042 EHR Alerts Boosted MRA Prescribing in HFrEF: BETTER CARE-HF https://www.medscape.com/viewarticle/989110 - Cluster-Randomized Trial Comparing Ambulatory Decision Support Tools to Improve Heart Failure Care https://doi.org/10.1016/j.jacc.2023.02.005 - The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure https://www.nejm.org/doi/full/10.1056/nejm199909023411001 V. Coffee - Acute Effects of Coffee Consumption on Health among Ambulatory Adults https://www.nejm.org/doi/full/10.1056/NEJMoa2204737 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Spironolactone maybe safe in pregnancy - Niacinamide riboside: Worse cancer in an animal model - TikTok has lots of info about AD--but at what cost? - Non-invasive treatments for calcinosis cutis - Behavioral economics in healthcare: Anchoring--with Steve Feldman! Connect with us! Web: https://dermaspherepodcast.com/ Twitter: @DermaspherePC Instagram: @dermaspherepodcast Facebook: https://www.facebook.com/DermaspherePodcast/ Check out Luke and Michelle's other podcast, SkinCast! https://healthcare.utah.edu/dermatology/skincast/ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: Kikoxp.com (a social platform for doctors to share knowledge) https://www.levelex.com/games/top-derm(A free dermatology game to learn more dermatology!) The University of Utah Dermatology Echo: https://physicians.utah.edu/echo/dermatology-primarycare

The Filtrate:Joel TopfJordy CohenNayan AroraSophia AmbrusoSpecial Guests:Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode (SODIUM-HF). His Google Schoolar page is better than yours. David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical & Translational Institute. Show Notes:Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome (The CARESS Trial)Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure (The UNLOAD trial)Diuretic Strategies in Patients with Acute Decompensated Heart Failure (The DOSE Trial)Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure (The 3T Trial)Sequential nephron blockade with a thiazide diuretic has a 1 B-NR (non-radomized) grade in the AHA/ACC Heart Failure Guidelines (7.2)Three important acute decompensated heart failure with SGLT2i:1. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure (SOLOIST-WHF Trial)2. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial (The EMPULSE Trial)3. Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art ReviewCardiologist Sues Epic Over Copyright InfringementOutcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: a propensity analysis.Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance (PubMed)Efficacy and Safety of Spironolactone in Acute Heart Failure (ATHENA Trial)Joel with a video on acetazolamide for altitude sickness. The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine(Amazon)

Welcome to The Treatment Room! In this episode, I'm answering your questions from IG! @myestytessa we explore: - spironolactone - growing on social - confidence - home spas - owning a biz - finding a mentor Want to support this episode and shop some Jan Marini? send me a dm: @myestytessa with the words 'JM product order' at the top, or email me: tessaskinconsulting@gmail.com with 'JM product order' in the subject line. To shop Glymed Plus, register on the top right via my authorized store: https://glymedplus.com/home/index Tess' Instagram @myestytessa Tess' YouTube: Tess Zolly Tess' TikTok: @myestytessa Music: Sweet by LiQWYD | https://www.instagram.com/liqwyd Music promoted by https://www.free-stock-music.com Creative Commons Attribution 3.0 Unported License https://creativecommons.org/licenses/by/3.0/deed.en_US MY SOCIAL MEDIA + SHOPS Now Booking Acne Bootcamp! Book a skin consultation or mentorship call with me: www.tessaskin.com For more details on my products, visit www.freeskinbytessa.com, or follow along on instagram @freeskinbytessa. This episode is sponsored by Gloss Genius. Promo Code: TTR22F Offer: 50% off for 2 months (new users only) (exp. 12/31/22) Link: https://glossgenius.biz/TTR22F-SIGN-UP --- Support this podcast: https://anchor.fm/the-treatment-room/support

Hyperkalemia in heart failure, CV health in America, primary prevention ICDs, and a debate about posters at medical meetings are the topics discussed by John Mandrola, MD in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Hyperkalemia in Heart Failure - DIAMOND: Adding Patiromer Helps Optimize HF Meds, Foils Hyperkalemia https://www.medscape.com/viewarticle/971616 - Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial https://doi.org/10.1093/eurheartj/ehac401 - Potassium Binders for Patients With Heart Failure? The Real Enlightenment of the DIAMOND Trial https://doi.org/10.1093/eurheartj/ehac399 - The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure https://www.nejm.org/doi/full/10.1056/nejm199909023411001 - Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms https://www.nejm.org/doi/full/10.1056/nejmoa1009492 - Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial https://pubmed.ncbi.nlm.nih.gov/21208974/ II. CV Health in America - ‘Staggering' CVD Rise Projected in US, Especially in Minorities https://www.medscape.com/viewarticle/978366 - Cardiovascular Disease Projections in the United States Based on the 2020 Census Estimates https://www.jacc.org/doi/10.1016/j.jacc.2022.05.033 III. Primary Prevention ICDs in Modern Era - Do ICDs Still ‘Work' in Primary Prevention Given Today's Recommended HF Meds? https://www.medscape.com/viewarticle/978254 - Guideline-Directed Medical Therapy and the Risk of Death in Primary Prevention Defibrillator Recipients https://doi.org/10.1016/j.jacep.2022.05.001 - Declining Risk of Sudden Death in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1609758 - Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1608029 IV. Medical Meetings and Posters - As Digital Posters Take Over, Traditionalists Push Back https://www.medscape.com/viewarticle/978384 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Therapeutic fashion and conduction system pacing, early rhythm control in AF, statins in CKD, and salt intake in HF are the topics discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I – Therapeutic Fashion and Conduction System Pacing - Medical Necessity vs Therapeutic Fashion: How Evidence-Based Is Your Field of Medicine? https://www.medscape.com/viewarticle/977358 - Conduction System Pacing Noninferior to Biventricular Pacing for HF With Wide QRS https://www.medscape.com/viewarticle/971740 - His Corrective Pacing or Biventricular Pacing for Cardiac Resynchronization in Heart Failure https://www.jacc.org/doi/full/10.1016/j.jacc.2019.04.026 II – Early Rhythm Control - Benefit of Early Rhythm Control Questioned in Newly Diagnosed Atrial Fibrillation https://www.medscape.com/viewarticle/977584 - Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy https://doi.org/10.1016/j.jacc.2022.04.058 - Early Rhythm-Control Therapy in Patients with Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa2019422 III – Statins and CKD - Rosuvastatin Again Linked With Risks to Kidneys https://www.medscape.com/viewarticle/977646 - Association of Rosuvastatin Use with Risk of Hematuria and Proteinuria https://doi.org/10.1681/ASN.2022020135 - Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis https://www.nejm.org/doi/10.1056/NEJMoa043545 - Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis https://www.nejm.org/doi/full/10.1056/nejmoa0810177 IV – Sodium and HF - Overly Tight Sodium Restriction May Worsen HFpEF Outcomes https://www.medscape.com/viewarticle/977441 - Salt restriction and risk of adverse outcomes in heart failure with preserved ejection fraction https://heart.bmj.com/content/early/2022/06/07/heartjnl-2022-321167 - Spironolactone for Heart Failure with Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/nejmoa1313731 - Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial https://doi.org/10.1016/S0140-6736(22)00369-5 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net