Podcast appearances and mentions of Howard Florey

Cap

Bu bölümde, 1945 Nobel Tıp Ödülü'nü kazanan Sir Alexander Fleming, Ernst Boris Chain ve Howard Florey'in insanlık tarihine damga vuran çalışmalarıyla tanışıyoruz. Penisilinin keşfi ve bu devrim niteliğindeki antibiyotiğin yaygın kullanımının, özellikle savaş sonrası dünya üzerinde nasıl bir etki yarattığını konuşuyoruz. İkinci Dünya Savaşı'nın ardından insan sağlığına yönelik bu büyük buluşun tıpta devrim yaratma sürecini, bilim insanlarının çetin yolculuklarını ve Nobel Komitesi'nin bu tarihi ödülü nasıl değerlendirdiğini tartışıyoruz

In this episode of Biographers in Conversation, Brett Mason chats with Gabriella about the choices he made while writing Wizards of Oz: How Oliphant and Florey helped win the war and shape the modern world.  Wizards of Oz is an account of a friendship between two Adelaide men, the physicist Mark Oliphant and medical researcher Howard Florey and how their scientific discoveries profoundly impacted the course of World War II. It is a gripping tale of secret missions, international intrigue and triumph against all odds.   Here's what you'll discover in this episode: Why Brett Mason chose to open Wizards of Oz with an electrifying prologue about Oliphant and Florey's high stakes, top secret missions to gain political and financial support from the American government and U.S. businesses for their scientific projects at a critical stage of World War II. Brett's research strategy and how he narrowed the biographical scope after uncovering an avalanche of primary source material.  How Brett learned about the intricacies of microwave technology, nuclear physics and penicillin research given his background in politics rather than science and medicine.  How Brett translated complex scientific information into a propulsive narrative that keeps you as the reader on the edge of your seat wondering what happens next. The extent to which Brett balanced scientific discoveries and advocacy with Oliphant and Florey's human stories. How Brett crafted a cohesive narrative from the experiences of two brilliant yet very different researchers who worked in disparate fields of science.  How Brett presented Oliphant and Florey's lives with immediacy, so you as the reader feel as if you are Oliphant and Florey experiencing their frustrations, fear and desperation to gain support for their scientific endeavours when the stakes were so high.  https://biographersinconversation.com Facebook: Share Your Life Story Linkedin: Gabriella Kelly Davies Instagram: Biographersinconversation

Fleming?! Pah! Behind every famous man is a team who made it work - this is the amazing story of how that team took Fleming's discovery of penicillin to the people. While Fleming discovered it, the development and production of what was hailed as a miracle drug is a much more interesting story than you would think. It's wartime England, and in a lab in Oxford university a team of scientists have made an amazing development of how to isolate and use the penicillin that Fleming discovered. But how are they going to produce this miracle drug in enough quantities to help? Find out the story of ingenuity and creativity that changed the world. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode 2364: Our featured article of the day is Howard Florey.

This episode covers the 1945 Nobel Prize in Physiology or Medicine, which was awarded to Alexander Fleming, Ernst Chain, and Howard Florey. The Nobel Assembly at the Karolinska Institute chose to give Fleming, Chain, and Florey the award “for the discovery of penicillin and its curative effect in various infectious diseases”. Topics include Fleming's completely accidental discovery of penicillin, how Chain and Florey turned penicillin into a global wonder drug, and some of the properties of a good antibiotic.

Serendipity, brilliance and hard work led to the development of penicillin, a drug that has saved billions of lives.

Serendipity, brilliance and hard work led to the development of penicillin, a drug that has saved billions of lives.

Serendipity, brilliance and hard work led to the development of penicillin, a drug that has saved billions of lives.

Serendipity, brilliance and hard work led to the development of penicillin, a drug that has saved billions of lives.

Alexander Fleming entdeckte das Antibiotikum Penicillin im Jahr 1928. Diese Entdeckung wurde aber von der Wissenschaftswelt kaum wahrgenommen und geriet in Vergessenheit. Erst durch die Arbeiten von Howard Florey und seiner Gruppe während des 2. Weltkriegs wurde Penicillin zum lebensrettenden Wundermittel für Millionen von Menschen weiterentwickelt. Weitere Informationen auf www.biofunk.net

Learn about the true history of penicillin; why wireless charging may be bad for your battery; and why the “alpha dog” is a canine myth. In this podcast, Cody Gough and Ashley Hamer discuss the following stories from Curiosity.com to help you get smarter and learn something new in just a few minutes: In the Story of Penicillin, Alexander Fleming Was a Minor Character — https://curiosity.im/2SD8bmX  Bad News: Wireless Charging May Be Bad for Your Battery — https://curiosity.im/2LspOoE  The "Alpha Dog" Is a Canine Myth — https://curiosity.im/2LrOCx7 Download the FREE 5-star Curiosity app for Android and iOS at https://curiosity.im/podcast-app. And Amazon smart speaker users: you can listen to our podcast as part of your Amazon Alexa Flash Briefing — just click “enable” here: https://curiosity.im/podcast-flash-briefing. 

ALEXANDER FLEMING (1881-1955) Foi um médico, biólogo botânico, microbiólogo e farmacologista britânico. Autor de diversos trabalhos sobre bacteriologia, imunologia e quimioterapia, notabilizou-se como o descobridor da proteína antimicrobiana lisozima, em 1923, e da penicilina, obtida a partir do fungo Penicillium notatum, em 1928, pela qual foi laureado Nobel de Fisiologia ou Medicina em 1945, juntamente com Howard Florey e Ernst Boris Chain. Seu pai era jardineiro de Winston Churchill. O filho de Churchill caiu no poço e Alexandre o salvou, por isso recebeu de Churchill como prêmio cursar medicina. Essa é a nossa história de hoje. Espero ter contribuído para que seu dia tenha momentos agradáveis! Se você gostou, deixe seu joinha. Compartilhe este conhecimento com os amigos. Vamos incentivar a cultura em nosso país! Ainda mais agora em épocas de coronavirus. É bom nos mantermos em casa, assistindo coisas boas. E se você puder contribuir para que o Canal Loucos por Biografia se mantenha Vivo e cada dia com mais qualidade, contribua com R$10,00 mensais no Catarse. O link do projeto está logo abaixo para quem quiser conhecer o projeto. Até á próxima história! Se cuidem! Fiquem em casa. (Tânia Barros). Projeto incentivo Canal - www.catarse.me/loucosporbiografias --- Send in a voice message: https://anchor.fm/loucosporbiografias/message

IFE Grand Challenge Lecture, recorded 25 May 2018 at QUT. Through the 20th century, research laboratories at the Universities of Oxford and Cambridge embodied two leading models of research, based on competing philosophies of how research is conducted and research teams are assembled and supported.The Cavendish Laboratory at Cambridge, under the guidance of J.J. Thomson and his acolytes, focused on recruitment and environment, producing a stunning succession of discoveries that underpin modern physics and chemistry. Several decades later, Howard Florey's team at Oxford took a problem-based approach, carefully assembling the team best equipped to solve the antibiotic challenge, resulting in the discovery that has arguably saved more lives than any other. Towards the end of the 20th century and on the other side of the world, policymakers and research administrators came together to develop a blended system that harnessed the best of each of these models. For more than a decade and supported by successive Australian governments, Backing Australia's Ability provided a coherent, overarching structure to nurture a research ecosystem in which each element could thrive in collaboration with the others. Professor Sheil will argue that examples of breakthrough innovation – such as the cervical cancer vaccine or CSIRO's invention of Wi-Fi – must be read in the context of this ecosystem approach, which underpinned a research model that is at once engaged yet open; problem-oriented yet curiosity-driven. This Grand Challenge Lecture is a call to arms for a revival and modernisation of such a systems approach, in which government, the universities, industry and the publicly funded research agencies each understand (and are funded for) their respective roles, yet find benefit in working collaboratively and generatively, within the most productive open-source template for adaptive innovation in the world of today and tomorrow.

IFE Grand Challenge Lecture, recorded 25 May 2018 at QUT.Through the 20th century, research laboratories at the Universities of Oxford and Cambridge embodied two leading models of research, based on competing philosophies of how research is conducted and research teams are assembled and supported.The Cavendish Laboratory at Cambridge, under the guidance of J.J. Thomson and his acolytes, focused on recruitment and environment, producing a stunning succession of discoveries that underpin modern physics and chemistry. Several decades later, Howard Florey’s team at Oxford took a problem-based approach, carefully assembling the team best equipped to solve the antibiotic challenge, resulting in the discovery that has arguably saved more lives than any other.Towards the end of the 20th century and on the other side of the world, policymakers and research administrators came together to develop a blended system that harnessed the best of each of these models. For more than a decade and supported by successive Australian governments, Backing Australia’s Ability provided a coherent, overarching structure to nurture a research ecosystem in which each element could thrive in collaboration with the others.Professor Sheil will argue that examples of breakthrough innovation – such as the cervical cancer vaccine or CSIRO’s invention of Wi-Fi – must be read in the context of this ecosystem approach, which underpinned a research model that is at once engaged yet open; problem-oriented yet curiosity-driven.This Grand Challenge Lecture is a call to arms for a revival and modernisation of such a systems approach, in which government, the universities, industry and the publicly funded research agencies each understand (and are funded for) their respective roles, yet find benefit in working collaboratively and generatively, within the most productive open-source template for adaptive innovation in the world of today and tomorrow.

Georgina Ferry interviews Eric Sidebottom. Eric Sidebottom has been associated with the Dunn School for more than 50 years, as medical student, lecturer, and recently, official historian. Sidebottom came to Oxford to read medicine at a time when two Nobel prizewinners, Howard Florey and Hans Krebs, were still lecturing to undergraduates. He completed his medical training at St Bartholomew’s Hospital in London and came to the Dunn School as one of Henry Harris’s first DPhil students in 1966. Sidebottom became interested in cancer, and used Harris's cell fusion technique to explore the ability of cancer cells to spread throughout the body, or metastasise. Following the death of John French, Harris appointed him to organise all the teaching in the department, which led him to administrative roles including chairing the board of the Faculty of Medicine. In the late 1980s Sidebottom moved to the Imperial Cancer Research Fund as Assistant Director of Clinical Research. Returning to the Dunn School after five years, he has since focused on the history of Oxford medicine, publishing Oxford Medicine: A Walk Through Nine Centuries, and Penicillin and the Legacy of Norman Heatley (with David Cranston).

Georgina Ferry interviews Pete Stroud. Pete Stroud is Mechanical Facilities Manager at the Dunn School, where he runs the maintenance and construction workshop. He has literally worked at the department ‘man and boy’, as his father ran the workshop before him, and as a teenager he used to help out in the holidays; since coming to work at the department he has lived on the site, in the flat formerly occupied by Howard Florey’s animal technician Jim Kent. Having originally intended to become an automotive engineer at the Cowley Works, Stroud found that he enjoyed the variety of work in the Dunn School workshops, and joined his father there as soon as he finished school. He pursued a succession of technical qualifications on day release, while designing and building equipment for scientific analysis, such as electrophoresis tanks and radiation screens. Stroud has seen demands on the workshop change as more equipment became available off the shelf, and computers became central to the control of many laboratory processes. But while maintenance has become a significant part of the work, innovative experiments still require some equipment to be designed and built on site.

Lincoln's medical breakthroughs: The past, present and future. Lincoln has a history of pioneering medical research, particularly in relation to developing penicillin and researching cell biology. In this Lincoln Leads session, Dr Eric Sidebottom (an authority on Oxford's medical history and former student of Lord Florey) takes us on a journey back in time to chart Lincoln's longstanding connection with the Dunn School and to take a closer look at some of the most famous Lincoln scientists - from John Radcliffe to Howard Florey and Norman Heatley. Returning to the present day, Professor David Vaux discusses his current research, which focuses on the nuclear envelope and its associated disease states. The nuclear envelope is the barrier between the nucleus and the rest of the cell, and his team study the roads and tunnels that carry molecules deep into or through the nucleus. If that wasn’t enough, the other team in his lab study how diseases such as Alzheimer’s, diabetes, and motor neuron disease work on the cellular level. Finally, after nearly a century of pathology-slanted studies, the Dunn School has begun turning its face to modern cell biology. Mustafa Aydogan will be addressing the present and future of this transition through the lens of his observations at the Dunn School, as well as the type of research he does in the laboratory on a daily basis.

Dr Sean Stevens sits down with Associate Professor Sue Benson, Infectious Diseases Physician and Microbiologist, to discuss Howard Florey, penicillin and all things antibiotics just in time for Global Awareness Week, 14-20 November.

The entire Dampier family has been ill with a really nasty virus. So apologies for taking this long to get this episode out. You may never have heard of Howard Florey. But chances are you owe this Australian your life or the life of someone close to you. His work on the development of the first penicillin-based antibiotic medicines in the 1940s has probably saved millions of people worldwide. We also revisit the Hilton Bombing. A new book by Rachel Landers called ‘Who Bombed the Hilton’ puts forward the case that it was actually the Ananda Marga that carried out the bombing. It seems I may have been wrong!!

Melvyn Bragg and guests discuss penicillin, discovered by Alexander Fleming in 1928. It is said he noticed some blue-green penicillium mould on an uncovered petri dish at his hospital laboratory, and that this mould had inhibited bacterial growth around it. After further work, Fleming filtered a broth of the mould and called that penicillin, hoping it would be useful as a disinfectant. Howard Florey and Ernst Chain later shared a Nobel Prize in Medicine with Fleming, for their role in developing a way of mass-producing the life-saving drug. Evolutionary theory predicted the risk of resistance from the start and, almost from the beginning of this 'golden age' of antibacterials, scientists have been looking for ways to extend the lifespan of antibiotics. With Laura Piddock Professor of Microbiology at the University of Birmingham Christoph Tang Professor of Cellular Pathology and Professorial Fellow at Exeter College at the University of Oxford And Steve Jones Emeritus Professor of Genetics at University College, London Producer: Simon Tillotson.

Melvyn Bragg and guests discuss penicillin, discovered by Alexander Fleming in 1928. It is said he noticed some blue-green penicillium mould on an uncovered petri dish at his hospital laboratory, and that this mould had inhibited bacterial growth around it. After further work, Fleming filtered a broth of the mould and called that penicillin, hoping it would be useful as a disinfectant. Howard Florey and Ernst Chain later shared a Nobel Prize in Medicine with Fleming, for their role in developing a way of mass-producing the life-saving drug. Evolutionary theory predicted the risk of resistance from the start and, almost from the beginning of this 'golden age' of antibacterials, scientists have been looking for ways to extend the lifespan of antibiotics. With Laura Piddock Professor of Microbiology at the University of Birmingham Christoph Tang Professor of Cellular Pathology and Professorial Fellow at Exeter College at the University of Oxford And Steve Jones Emeritus Professor of Genetics at University College, London Producer: Simon Tillotson.