Podcast appearances and mentions of jon epstein

Judiciary expert Carl Tobias, a professor at the University of Richmond Law School, discusses the Supreme Court adopting an ethics code. Media law expert Jon Epstein, a partner at Hall Estill, discusses the reporter's privilege. June Grasso hosts.  See omnystudio.com/listener for privacy information.

Judiciary expert Carl Tobias, a professor at the University of Richmond Law School, discusses the Supreme Court adopting an ethics code. Media law expert Jon Epstein, a partner at Hall Estill, discusses the reporter's privilege. June Grasso hosts.  See omnystudio.com/listener for privacy information.

Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in the basic science and technology of defining, diagnosing and treating NAFLD and NASH. This conversation focuses largely on the implications of potentially exciting future technologies such as the mRNA/CAR-T therapy described in Conversation 17.1 on NASH drug development today.After the earlier discussion of the potential future mRNA/CAR-T therapy, Scott Friedman turns to Neil Henderson and asks this question: "What cell type and what receptors on those cells do you hone in on or do you do more than one? And how do you use single cell genomics to help you sort through that complex question?"Neil immediately connects the question and the technology to the need for precision medicine in NASH. He points out that one challenge with NASH is hitting a single target is always challenging, particularly when the target is as "evolutionarily conserved" as fibrosis. To Neil, this suggests that if the mRNA/CAR-T therapy comes to fruition, it will become one element -- an important one, but not the only one -- in what he describes as "multimodal combinatorial therapy" which combines medicines and technology to attack fibrosis, perhaps all at once or possibly in stages.Stephen Harrison says this information leaves him feeling like he is "very much at the very tip of the archeological dig" into what we know about treating Fatty Liver disease. He points out that one rule in drug development today is "if you get rid of the fat, the liver will take care of itself." Following this logic, he suggests the best place for something like the mRNA/CAR-T approach might be in cirrhotic or pre-cirrhotic patients with the goal of regressing fibrosis sufficiently that other more metabolic drugs might become appropriate and adequate as therapyScott points out that 90% of all fatty livers never go on to develop cirrhosis. Given this fact, one key focus of learning must be determine why it is that some livers progress and others do not. This would allow us to develop therapies targeted at the livers that progress and the cellular or genetic factors that lead them to do so. This, Scott points out, leads us back to the question of how we can use single cell technologies to learn the role that each cell type plays at different points in disease progression. This leads to a discussion between Neil, Scott and Stephen about the specific challenges of obtaining the liver tissue necessary for these kinds of assessments.

Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in advanced NASH omics, including work on mRNA/CAR-T anti-fibrotic therapies. There is not enough room to capture this entire conversation in a summary. It's a lot, but really eye-opening and exciting. Take the time to listen to the entire episode, even if in bite-sized pieces.This episode starts with bonhomie and humor as the group congratulates Professor Friedman on being honored with a Lifetime Achievement Award from the faculty at Mt. Sinai, and then listens as Professor Henderson relates one of the most truly unique "one thing you wouldn't know about me if I didn't tell you" in the history of the podcast.The science portion of the podcast starts with Scott discussing a fantastic series of advances in basic science, wherein researchers have begun to evaluate CAR-T therapy, which was originally developed to treat lymphomas and other blood dyscrasias, to attack the surfaces of fibrogenic cells in the liver (MSK, New York) or, separately, the heart (University of Penn). Today, we create CAR-T cells by taking cells from the diseased patient, re-engineering them and injecting them back into the patient. This approach  is associated with high rates of Level 3+ cytokine response syndrome (CRS). It has also been found to leave this engineered CAR-T material in the patient's system for at least a decade after therapy.Scott goes on to explain how the Epstein lab at Penn integrated the CAR-T strategy with mRNA, the protein behind the Pfizer/BioNTech and Moderna DOVD-19 vaccines, to create a vaccine that can reprogram cells within the body to replicate the CAR-T effect. Scott notes that so far, this has only been reported in mouse models, and that there are many major issues to resolve before we know it will be safe and effective in humans. It is a staggering  breakthrough nonetheless.After a couple of questions, the group turns to Neil, who points out that this kind of finding can help "make precision medicine a reality," in part because it creates the possibility we can target multimodal therapy at the precise location it is needed. Stephen suggests that the ideal place for this kind of therapy might be in a late-stage patient where we can regress fibrosis and, once the liver is better able to function, resort to a more metabolic therapy. Scott suggests how helpful it would be to develop insight into how different types of cells respond to different medication, which shifts the conversation  toward the broader topic of single-cell genomics, and specifically, the growing utility of spatial transcriptomics in these situations. Neil provides a description of the benefits of spatial transcriptomics, and then takes the group back  through a history of omic technology.Jörn Schattenberg asks what these techniques have taught us about variability between patients. Neil discusses the congruence of individual samples.  Jörn points out this would mean that we can develop robust therapies targeted at a cell type. Scott suggests that we can use these insights to standardize clinical trials, to target the specific patients with the genetic targets most likely to respond  -- a large step on the path to personalized precision therapy.In response to a question from Louise Campbell about sources for liver tissue, Neil asks for study purposes, "What is a normal human liver?" One of his major sources of tissue  are distal liver sites from patients with colorectal cancer. However, even if these are cancer free, thy could be affected by chemotherapy.As discussion winds down, the group comes to focus on the issue of why and how the liver regenerates. It raises fascinating questions: why does it not seem to "over-regenerate?" Are the regenerated cells different from pre-injury cells, and if so, how?

Today, Dr. Sip schools Melissa on why bats get a bad rap (and how much of the movie "Contagion" is real), and Melissa teaches Dr. Sip about sexy cicadas that would make Jerry Springer beg for a priest.Resources: Dr. Jon Epstein and his incredible work with bats, education and preventing zoonotic diseases: https://www.ecohealthalliance.org/about Dr John Epstein: Virus HunterBrood XXXWBUR: Sex Crazed Fungus Butt CicadasWhat IS Brood X? CBSVarmints Podcast - Cicadas Dr. Sip is a practicing veterinarian in and around Oakland/Berkeley, California. More about Dr. Sip and her veterinary work can be found here: DrSipVet.com/Melissa can be heard on her other podcast, BewilderBeasts (safe for work and kids, unlike this show!) and at MelissaMcCueMcGrath.comFind them on Twitter: @PawsomePodEmail your story ideas, fan art, comments and more: TotallyPawsomePod@Gmail.com 

Join us for this special Pride Month episode in celebration of the power of community, hope, and recovery. George Costanzo of The LGBT Community Center of Greater Cleveland and NAMI volunteer Jon Epstein join NAMI GC Program Director, Megan Rochford & mental health advocate Portia Booker to talk about LGBT mental health.

On this week's episode, I am pleased to re-broadcast a recent webinar that took place in which colleagues of mine gave a behind the scenes look at how we won the Real Estate Board of New York's Edward S. Gordon Memorial Deal of the Year Award. In this broadcast, Susan Kanaher, Jennifer Ogden and Jon Epstein from our New York office give listeners an inside look at the structure of the deal and what made it so difficult to accomplish.

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

To fight a pandemic, you need to first understand where a virus comes from. That quest takes disease ecologist Jon Epstein to gloomy caverns where bats hang out. There he checks up on hundreds of the animals as his team from the EcoHealth Alliance trace the origins of disease-causing viruses. But their important work is facing its own threat; the Trump administration recently terminated funding to the Alliance because of its collaboration with Chinese scientists. Hear how Dr. Epstein finds the viruses, what kind of human activity triggers outbreaks, and how science counters the unsubstantiated claim that the virus escaped from a lab. Guests: Jon Epstein – Veterinary epidemiologist with the nonprofit EcoHealth Alliance Meredith Wadman – Staff writer for the journal Science. Read her article about the cancellation of the NIH bat coronavirus grant.

To fight a pandemic, you need to first understand where a virus comes from. That quest takes disease ecologist Jon Epstein to gloomy caverns where bats hang out. There he checks up on hundreds of the animals as his team from the EcoHealth Alliance trace the origins of disease-causing viruses. But their important work is facing its own threat; the Trump administration recently terminated funding to the Alliance because of its collaboration with Chinese scientists. Hear how Dr. Epstein finds the viruses, what kind of human activity triggers outbreaks, and how science counters the unsubstantiated claim that the virus escaped from a lab. Guests: Jon Epstein – Veterinary epidemiologist with the nonprofit EcoHealth Alliance Meredith Wadman – Staff writer for the journal Science. Read her article about the cancellation of the NIH bat coronavirus grant. Learn more about your ad choices. Visit megaphone.fm/adchoices

In der ersten Folge von Pandemia begibt sich das Team nach China, zum Urspung von SARS-CoV-2. Dass das Coronavirus von Wildtieren auf den Menschen übergesprungen ist, gilt als sicher. Aber wie passiert so etwas? Und warum - wie schon bei SARS - ausgerechnet in China? Kai sprach darüber mit dem Veterinärmediziner Jon Epstein von der Eco Health Alliance. Doch China war nicht nur das erste Land mit Fällen der neuen Erkrankung. Es hat auch als erstes Land die Ausbreitung des Virus in den Griff bekommen. Wie haben Menschen dort den Lockdown erlebt? Wo ist die Grenze zwischen Schutz der Bevölkerung und autoritärer Überwachung? Laura hat darüber mit der chinesischen Autorin Sun gesprochen. "Pandemia" unterstützen? Komm’ in den Klub Viertausendhertz: klub.viertausendhertz.de Apple Podcasts: apple.co/2yA3l3L Spotify: spoti.fi/2V7hkFI Social Media: twitter.com/pandemiapodcast instagram.com/pandemiapodcast

In der ersten Folge von Pandemia begibt sich das Team nach China, zum Urspung von SARS-CoV-2. Dass das Coronavirus von Wildtieren auf den Menschen übergesprungen ist, gilt als sicher. Aber wie passiert so etwas? Und warum - wie schon bei SARS - ausgerechnet in China? Kai sprach darüber mit dem Veterinärmediziner Jon Epstein von der Eco Health Alliance. Doch China war nicht nur das erste Land mit Fällen der neuen Erkrankung. Es hat auch als erstes Land die Ausbreitung des Virus in den Griff bekommen. Wie haben Menschen dort den Lockdown erlebt? Wo ist die Grenze zwischen Schutz der Bevölkerung und autoritärer Überwachung? Laura hat darüber mit der chinesischen Autorin Sun gesprochen. "Pandemia" unterstützen? Komm’ in den Klub Viertausendhertz: klub.viertausendhertz.de Apple Podcasts: apple.co/2yA3l3L Spotify: spoti.fi/2V7hkFI Social Media: twitter.com/pandemiapodcast instagram.com/pandemiapodcast

In der ersten Folge von Pandemia begibt sich das Team nach China, zum Urspung von SARS-CoV-2. Dass das Coronavirus von Wildtieren auf den Menschen übergesprungen ist, gilt als sicher. Aber wie passiert so etwas? Und warum - wie schon bei SARS - ausgerechnet in China? Kai sprach darüber mit dem Veterinärmediziner Jon Epstein von der Eco Health Alliance. Doch China war nicht nur das erste Land mit Fällen der neuen Erkrankung. Es hat auch als erstes Land die Ausbreitung des Virus in den Griff bekommen. Wie haben Menschen dort den Lockdown erlebt? Wo ist die Grenze zwischen Schutz der Bevölkerung und autoritärer Überwachung? Laura hat darüber mit der chinesischen Autorin Sun gesprochen. "Pandemia" unterstützen? Komm' in den Klub Viertausendhertz: klub.viertausendhertz.de Apple Podcasts: apple.co/2yA3l3L Spotify: spoti.fi/2V7hkFI Social Media: twitter.com/pandemiapodcast instagram.com/pandemiapodcast

In der ersten Folge von Pandemia begibt sich das Team nach China, zum Urspung von SARS-CoV-2. Dass das Coronavirus von Wildtieren auf den Menschen übergesprungen ist, gilt als sicher. Aber wie passiert so etwas? Und warum - wie schon bei SARS - ausgerechnet in China? Kai sprach darüber mit dem Veterinärmediziner Jon Epstein von der Eco Health Alliance. Doch China war nicht nur das erste Land mit Fällen der neuen Erkrankung. Es hat auch als erstes Land die Ausbreitung des Virus in den Griff bekommen. Wie haben Menschen dort den Lockdown erlebt? Wo ist die Grenze zwischen Schutz der Bevölkerung und autoritärer Überwachung? Laura hat darüber mit der chinesischen Autorin Sun gesprochen. "Pandemia" unterstützen? Komm’ in den Klub Viertausendhertz: klub.viertausendhertz.de Apple Podcasts: apple.co/2yA3l3L Spotify: spoti.fi/2V7hkFI Social Media: twitter.com/pandemiapodcast instagram.com/pandemiapodcast The post China - Wildtiermärkte und WeChat first appeared on Viertausendhertz | Das Podcastlabel.

FILA’s VP of Heritage & Trend, Louis Colon details their unique approach to marketing and how the brand’s comeback is here to stay. He tells us about his rocky beginnings from calling quits on his sneaker businesses to party promoting to working in temp jobs to eventually landing a job at FILA under the guidance of the late Jon Epstein. As always, thank you for tuning into HYPEBEAST Radio and Business of HYPE. Please don't forget to rate, comment and subscribe to our other shows MIC/LINE, The Anthropology, The HYPE Report and HYPETALKS. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/businessofhype/support

Jon Barr loses his mind in this one! Jon and Jon Epstein talk about the confusing cast of characters in the newly announced Funko figures movie, along with the Lazy Bowler Lebowski and their weird Quaker pasts. VOTE IN THE 2019 DETECTY AWARDS! https://goo.gl/forms/tNaiGwKfEGrF1UK23 Jon Barr: @JonBarrTweets Jonathan Epstein: @___j0nathan

Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World. Host: Vincent Racaniello Guests: Sabrina Sholts, Jon Epstein, and Ed Niles Become a patron of TWiV! Links for this episode Sabrina Sholts Jonathan Epstein EcoHealth Alliance Outbreak at the Smithsonian ASM partners with Smithsonian (bLog Phase) Vincent as museum object (AMNH) Video of this episode (YouTube) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Jonathan Epstein. He’s the current senior VP for international at Sentient Technologies, the maker of Sentient Ascend, the first conversion optimization solution that is powered by evolutionary artificial intelligence. Epstein has been in many companies at the forefront of technology and media including GameSpot, which he’s the founding CEO, and Omek which was sold to Intel and GameSpy which was eventually sold to IGN.   Famous Five: Favorite Book? – Hire With Your Head What CEO do you follow? – Elon Musk and Jeff Bezos Favorite online tool? — BuiltWith and SimilarWeb How many hours of sleep do you get? — 5-6 If you could let your 20-year old self, know one thing, what would it be? – “I wished I had stepped on entrepreneurship early”   Time Stamped Show Notes: 01:22 – Nathan introduces Jon to the show 02:18 – Jon’s good exit range is from tens of millions to the hundreds of million dollars 02:39 – Jon helped the founding CEO of Gamespot turn it around 03:18 – Jon has worked in an actual gaming company 03:29 – Jon started at IDG as magazine publisher 03:49 – GameSpot was the first professional online review site for games 03:56 – GameSpy had an editorial element and Jon published some of its software 04:35 – GameSpot was launched in 1995 04:45 – Jon launched the magazine Digital News and Multimedia World 04:53 – Jon was working for IDG when he launched the magazines under their brand 05:28 – Jon had great partners when he started GameSpot 05:55 – The initial idea came from the 2 co-founders 06:20 – It was clear that the internet thing was happening 06:30 – The problem, then, was that the release of the magazine came out way too late for newly released game reviews 06:55 – Having the magazine online is a better way to update the gamers 07:13 – GameSpot took in external investors 07:34 – GameSpot was sold for stock in ZDNet 08:09 – Jon had an international role and wanted to gain experience in dealing with other countries 08:16 – ZDNet had joint ventures and Jon had been with them for a while 08:34 – Jon had invested from ZDNet to GameSpy 09:04 – Jon had 8% of GameSpy 09:28 – Jon joined GameSpy in September 2001 09:32 – GameSpy was sold in March 2004 10:01 – Jon made around $61M cash from GameSpy’s exit 10:21 – Jon stayed with IGN after the exit and stayed there for a while 10:30 – Jon joined Double Fusion, which is a venture-backed startup 10:55 – Sentient had been around for 9 years and was one of the best funded companies 11:21 – Jon fell in love with Sentient because of their goals 11:29 – Sentient was built with a powerful AI platform 11:34 – It focuses on AI at scale and is able to run AI problems across millions of GPUs 11:58 – Sentient does multiple types of AI 12:00 – One is deep learning or neuron-network which is used for handwriting, voice recognition and image analysis 12:12 – Another product of Sentient is the evolutionary computation which is an AI that mimics natural selection 12:38 – Sentient ran a hedge fund using their products 12:51 – The fund size is growing rapidly 13:14 – Big investors invest to hedge funds in order to achieve stable, good returns 14:16 – Sentient is a SaaS business disrupting the world of AB testing 14:48 – Using the evolutionary AI approach speeds up AB testing 15:41 – Sentient currently has 25 paying customers 15:52 – Average contract price is $3K-30K a month 16:12 – Zero customer churn 16:24 – CAC 16:52 – Sentient is also doing paid advertising 16:56 – Sentient attends conversion conferences where they spend $5K-10K for sponsorship 17:40 – Sentient has raised a total of $143M 17:52 – Sentient has around 110 employees 17:58 – There are still 15-20 open positions 18:24 – Sentient was founded in 2007 18:57 – “We think it’s too early to sell” 19:15 – Mark Cuban said that the first trillionaires will come from AI 20:35 – The Famous Five   3 Key Points: Never be scared about exits – it just means new doors are opening for you. Be in a company that you’re really interested in—where you can align yourself with their goals. Start as early as you can when it comes to entrepreneurship.   Resources Mentioned: The Top Inbox – The site Nathan uses to schedule emails to be sent later, set reminders in inbox, track opens, and follow-up with email sequences Organifi – The juice was Nathan’s life saver during his trip in Southeast Asia Klipfolio – Track your business performance across all departments for FREE Acuity Scheduling – Nathan uses Acuity to schedule his podcast interviews and appointments Host Gator– The site Nathan uses to buy his domain names and hosting for the cheapest price possible Audible– Nathan uses Audible when he’s driving from Austin to San Antonio (1.5-hour drive) to listen to audio books Freshbooks – Nathan doesn’t waste time so he uses Freshbooks to send out invoices and collect his money. Get your free month NOW Show Notes provided by Mallard Creatives

There’s no doubt that Ebola is an incredibly dangerous and genuinely lethal virus, but it’s also a highly manageable one, though you’d be forgiven for thinking otherwise given the kind of hyperbolic coverage we’ve seen of the epidemic. In order to sort fact from fiction about the real threat posed by Ebola, and to better understand its origins and wider implications, Point of Inquiry presents a special episode, recorded before a live audience in New York.   We begin with a presentation by Dr. Jon Epstein, a veterinarian and epidemiologist who specializes in emerging pandemic threats in the developing world. Then Point of Inquiry host Josh Zepps goes more in depth, in a conversation with Dr. Epstein and Dr. Kevin Olival, a disease ecologist and evolutionary biologist. Both are world-leading experts on Ebola and disease prevention with a great deal of insight as to what governments and aid workers need to do to prevent Ebola from becoming a pandemic.    Recorded live at the Brooklyn Brewery, this event was organized by Eco Health Alliance, an international biodiversity organization. 

JP finally gets a vacation from the Poobah, leaving Mike and Neil to banter about leadership changes at Asics and REI, while also paying homage to Jon Epstein. Our guest is venture capitalist Keith Bank. Support this podcast at — https://redcircle.com/sport-lifestyle-podcast/donations

Original Show Notes: Becoming an entrepreneur   Nomad Trading Co. was founded in Summer 2016 by college friends Max Keilson and Jon Epstein to change how people treat drinks and snacks. “We believe that you are what you eat. We wanted to consume things that were healthy, but that also are sourced to the highest ethical standards, and with a pointed focus on sustainability.”   Welcome, Max! [2:51] Tell us a little more about yourself. ·      Co-founder of Nomad Trading ·      Grew up in Maryland ·      25 years’ old [3:32] You could have created any industry. Why teas? ·      Tea found me ·      Wanted to repurpose underused agricultural products [6:23] What was your biggest concern? ·      Were people going to try the tea [7:11] Where can we try your tea? ·      New York based ·      Whole Foods in upcoming year [8:16] How did you get funding? Savings? Investing? ·      Saved up ·      Got funding [9:4] Tell us a mess up story. ·      Bottling disaster ·      Cheaper is not always better Sponsors [12:24] Chain of Wealth – Trying to get out of debt can be really toughm but we’ve got some fantastic news! We’ve written a fantastic guide on how to get out of debt that anyone can use. Check it out today to get ahead and learn the basics of getting debt free! If you’re enjoying this podcast, don’t forget to subscribe, rate and review! Value Link Round (VLR) [12:51] Do you have any books or podcasts you recommend? ·      Books: Camp, Principals ·      Podcasts: How I build this, Tim Ferriss, snap judgement, nocturne, dirt bag diaries [15:58] Do you have a favorite quote? [16:44] How can people get in touch with you? ·      Instagram ·      Twitter ·      LinkedIn [17:4] Any last advice? ·      Set goals Support this podcast at — https://redcircle.com/chain-of-wealth-debt-investing-entrepreneurship-wealth-and-more/donationsWant to advertise on this podcast? Go to https://redcircle.com/brands and sign up.