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In this Editor's Special of The HemOnc Pulse, Tycel Phillips, MD, joins an editor of Blood Cancers Today to break down the latest research in B-cell non-Hodgkin lymphoma presented at the 2025 ASCO Annual Meeting. The conversation spans follicular lymphoma, CLL, mantle cell lymphoma, and large B-cell lymphoma, covering key insights on BTK/BCL2 inhibitors, bispecifics, CAR T-cell therapy, and more.

On todays feature of Crash Cart, we got to sit down with our friend, Arden Ballard, and talk about hydration, the factors of it, the benefits, and how our sponsor LMNT does it the best.

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain dive deep into the world of diffuse large B-cell lymphoma (DLBCL), one of the most aggressive yet potentially curable lymphomas. We are joined by Dr. John Leonard, a renowned lymphoma expert from NYU Langone Cancer Center, who shares his insights on the latest data and evolving treatment landscape for DLBCL. Episode Highlights: •⁠  ⁠Understanding the initial workup for DLBCL, including the role of PET-CT and bone marrow biopsies. •⁠  ⁠The use of RCHOP and the emerging Pola-R-CHP regimen in Stage 1 and Stage 2 settings. •⁠  ⁠Discussion on the treatment options for Stage 3 and Stage 4 disease, including the impact of polatuzumab. •⁠  ⁠Insights into managing relapsed/refractory disease and the role of CAR-T therapy. •⁠  ⁠The potential shift towards outpatient CAR-T treatments and the nuances between different CAR-T options. •⁠  ⁠Exploring bispecific antibodies and their applications in treatment sequencing. YouTube: https://youtu.be/raGkPnUs9XM Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Join us as we unpack the complexities of DLBCL treatment and share valuable clinical pearls for community settings. Don't forget to subscribe for more episodes on challenging cases and the latest in oncology!

In this episode, Associate Editor Dr. Philippe Armand discusses the Review Series on mantle cell lymphoma with author Dr. Christine Ryan. Both were authors of "Frontline management of mantle cell lymphoma", and discuss shifts in treatments and new research.Find the full review series in Volume 145 Issue 7 of Blood: "Review series on mantle cell lymphoma: sands shifting in the darkness"

In this episode of ASTCT Talks, Dr. Rahul Banerjee sits down with Dr. Kenneth Lim and Dr. Yi Lin of Mayo Clinic to discuss a critical and emerging topic in CAR T-cell therapy: delayed neurotoxicities following cilta-cel treatment in multiple myeloma. They break down the clinical features of nerve palsies and Parkinsonism-like symptoms, share diagnostic and treatment strategies and explore emerging predictive markers like absolute lymphocyte count. Given that cilta-cel is increasingly being used in second-line myeloma treatment and is even being studied in first-line treatment to replace stem cell transplantation, this conversation is a timely and insightful look at improving patient outcomes in CAR T-cell therapy.

Hosts Karl and Taylor are joined by Patrick Pierre, who shares his transformative journey from being a pharmacy major to becoming a successful Shopify developer and YouTuber.Patrick touches on the challenges and insights he gained while transitioning into the tech world, the importance of leveraging AI in content creation, and his current focus on app development. He emphasizes the value of community and consistency in both his YouTube channel and his development projects, providing listeners with a wealth of knowledge and inspiration for their own journeys.TakeawaysLiving on a budget and saving money can provide the freedom to pursue passions without financial stress.Attending industry events is crucial for networking and learning about the developer community.Introverts can develop social skills through practice and by engaging in activities like dance classes.Self-discipline is key to personal growth and achieving goals, as highlighted by Patrick's experiences.Fitness doesn't require daily gym visits; three workouts a week can be sufficient for maintaining health.Eating well is essential for energy and motivation, impacting overall productivity.The Shopify change log includes important updates that developers need to be aware of for app development.Recommendations for personal growth include reading influential books and engaging in community activities.Finding balance in life and work is essential for long-term success and happiness.Timestamps00:00 Introduction08:59 From Pharmacy to Development: A Life Change17:03 The Journey into Shopify Development24:58 Leveraging AI in Content Creation29:08 Transitioning to App Development36:01 Building a Shopify App: Insights and Challenges41:36 Navigating Time Management and Focus44:32 Living on a Budget and Financial Planning45:16 Building Community in the Developer Space48:44 The Importance of Networking and Learning49:50 Overcoming Introversion and Social Skills52:56 Self-Discipline and Personal Growth56:07 Fitness Routines and Healthy Living01:04:21 The Change Log and Shopify Updates01:08:41 Picks of the Week: Recommendations and InsightsFind Patrick OnlineYouTube:  https://www.youtube.com/@codethatconverts  LinkedIn: https://www.linkedin.com/in/patrick-pierre-856972149/ Twitter(X): https://x.com/Pierre_WebDev Website: https://www.patrickpierre.dev/ ResourcesHow AI is changing software engineering at Shopify with Farhan Thawar: https://newsletter.pragmaticengineer.com/p/how-ai-is-changing-software-engineeringDeepSeek: https://chat.deepseek.comDev Changelog[action required] New Built for Shopify requirements for marketing apps – Effective July 1, 2025 - https://shopify.dev/changelog/new-built-for-shopify-requirements-for-marketing-apps-effective-july-1-2025[action required] POS UI Extensions 2025-07 update - https://shopify.dev/changelog/pos-ui-extensions-2025-07-update[action required] Changes to Cart token format for AJAX and Storefront GraphQL Cart APIs - https://shopify.dev/changelog/changes-to-cart-token-format-for-ajax-and-storefront-graphql-cart-apisOrder cancellation now supports refunds to store credit - https://shopify.dev/changelog/ordercancel-mutation-now-supports-refunds-to-store-creditRequest app reviews in admin with the new Reviews API - https://shopify.dev/changelog/request-app-reviews-in-admin-with-the-new-reviews-apiPicks of the WeekKarl - Dungeon Crawler book seriesPatrick - Pomodoro Timer and Captivate Vanessa EdwardsTaylor - Evo TLV2 Air Tent and Instant Canopy TentsSign Up for Liquid WeeklyDon't miss out on expert insights and tips—subscribe to Liquid Weekly for more content like this: https://liquidweekly.com/

During the 18th International Conference on Malignant Lymphoma (ICML), Jun 17–21, 2025, Lugano, CH, the Lymphoma Hub held a symposium on June 17, 2025, titled Customizing therapy for mantle cell lymphoma (MCL). Here, we share a presentation by Julie Vose, University of Nebraska Medical Center, Omaha, US, discussing unmet needs in the treatment of MCL. Vose provides an overview of the current treatment landscape for patients with MCL, including Bruton's tyrosine kinase inhibitors (BTKi), chimeric antigen receptor (CAR) T-cell therapies, and bispecific antibodies. Vose also discusses mechanisms of resistance to BTKi and the impact on patient outcomes. This educational resource is independently supported by Eli Lilly and Company. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource. Hosted on Acast. See acast.com/privacy for more information.

Hoy tenemos una consulta muy interesante que nos envía María, dirigida a un profesional del casco. Nos habla de la osificación de los cartílagos alares, una patología que muchas veces se asocia a caballos herrados… pero que también ha observado en caballos descalzos desde siempre.Para responder, contamos con Albert Villasevil, podólogo equino y co-creador de la marca de botas EvoHorse, que nos ofrece una visión amplia, honesta y muy didáctica.Desde lo que sí sabemos con certeza hasta lo que aún estamos intentando comprender, Albert repasa las causas más probables de esta patología, y nos brinda una explicación clara y bien estructurada. Como él mismo dice, no se trata de dar respuestas absolutas, sino de poner sobre la mesa lo que la experiencia y la ciencia han podido aportar hasta ahora… y lo que todavía queda por descubrir.***** Para saber más sobre Albert :Web : https://podologia-equina.com/Inicio.phpInstagram : https://www.instagram.com/podologia_equina_catalunya/ ***** Deja tu pregunta en audio aquí explicando tu caso e inquietud : https://www.speakpipe.com/askthemodernrider Sigue a The Modern Rider :https://www.instagram.com/the_modern_rider/https://www.facebook.com/The-Modern-Rider-Podcast-172209469997478 https://www.themodernrider.com/Inscíbete a la nueva Newsletter especial de The Modern Rider : https://themodernrider.substack.comRecibe las comunicaciones del podcast : https://themodernrider.systeme.io/newsletterContacto : hola@themodernrider.comSupport the show

BJ has gotten paranoid that someone is going to confront him about how he handles shopping carts at grocery stores.

Pesquisa realizada pela Confederação Nacional e Dirigentes Lojistas (CNDL) e pelo Serviço de Proteção ao Crédito (SPC Brasil) aponta que mais da metade dos consumidores não fazem controle dos gastos mensais com cartão de crédito. Isso é motivo de preocupação, pois, no longo prazo, gera complicações financeiras às famílias. Para falar sobre o assunto, convidamos Merula Borges, coordenadora financeira e administrativa da CNDL e especialista em investimentos. Merula fala sobre os cuidados a se tomar antes de comprar no crédito e dá dicas de como fazer o controle dos gastos e negociar dívidas já existentes.

Last time we spoke about the end of the Bougainville campaign. In June 1945, the Australia and Allied forces intensified their campaign in the Pacific, spearheaded by General Hammer, as they battled entrenched Japanese troops on Bougainville. Following the capture of the Soraken Peninsula, the Australians aimed to control the strategic Hongorai River but faced fierce resistance. Meanwhile, General Kanda adjusted his strategies, pulling back Japanese forces to a defensive perimeter around Buin, allowing his troops to regroup. Australian battalions, notably the 24th and 57th/60th, pressed forward, making significant gains despite encountering numerous obstacles, including concealed mines and relentless counterattacks. The turning point came when they crossed the Hongorai River, marking a vital milestone in their advance. Ultimately, the combination of perseverance and tactical maneuvers set the stage for future successes within the broader context of the Pacific Theater. This episode is the Fall of Wewak Welcome to the Pacific War Podcast Week by Week, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about world war two? Kings and Generals have an assortment of episodes on world war two and much more  so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel you can find a few videos all the way from the Opium Wars of the 1800's until the end of the Pacific War in 1945.  In the last episode we finished off the Bougainville campaign. Now its been 4 long ass grueling years for the boys fighting in New Guinea. Today we are finally going to finish that story.  As we last saw, by early April 1945, General George Stevens and his 6th Australian Division were making significant strides in their Wewak offensive. The campaign, aimed at capturing the strategically important town of Wewak, was crucial for disrupting Japanese forces in New Guinea and aiding in their eventual defeat. Brigadier King's 16th Brigade had effectively secured the But and Dagua areas, notable locations that played vital roles in the region's agricultural landscape and supply lines. Simultaneously, Brigadier Moten's 17th Brigade was concentrating its efforts along the Ninab River, a key waterway that would facilitate the final drive toward Maprik, a town essential for both its infrastructure and resources. Facing intense Australian pressure, the remnants of General Mano's 41st Division were forced to retreat northwestward to Wora, a strategic village located near the coast, while the Miyake Force reorganized itself along the defensive line formed by the Imbia, Neligum, Kumbungua, and Bainy rivers. This area is characterized by its rugged terrain, dense jungles, and numerous waterways, making it a challenging environment for military operations. On April 3, General Moten ordered the 2/7th Battalion to advance toward Maprik and the Agricultural Station, aiming to seize this vital supply center. At the same time, the 2/6th Battalion was tasked with moving towards the Screw River to block any potential enemy retreats to the north. Hayforce, a composite group of Australian troops, was directed to push forward to the Maprik-Marui road. This mission was critical as it aimed to establish a new airfield, designated as Hayfield, to alleviate the pressing supply issues faced by Australian forces. The Australians began their assault towards Maprik, yet they quickly discovered that the enemy was well-prepared to defend this food-producing region. Throughout the week, they were largely limited to patrol actions as they engaged with scattered enemy forces. Concurrently, Hayforce advanced eastward, encountering strong resistance at Wora on April 10. This strategic location, once teeming with activity, had become a focal point for Japanese defense. On April 12, feeling increasingly under pressure, General Mano opted to abandon Wora, allowing him to concentrate his forces more effectively at Bainyik. This decision was pivotal, as it permitted Australian forces to secure the site of the proposed airstrip, enhancing their logistical capabilities.  Meanwhile patrols had been pressing on from village to village. On 28th March, for example, Sergeant J. W. Hedderman, of the 2/6th, a notable leader in these as in earlier operations, had led a reconnaissance to Kulkuil and Gwanginan. Next day he led a fighting patrol which took Kulkuil with a carefully-planned surprise attack. On the 30th Lieutenant Errey's platoon (16), with Hedderman as platoon sergeant, attacked Gwanginan. Hedderman confused the enemy by shouting to imaginary platoons to right and left (thus incidentally drawing fire on himself); and when the leading section was halted he brought down supporting fire and enabled it to move again. A man was wounded within 10 yards of the enemy's pits; Hedderman went forward, killed two Japanese with grenades, and dragged his comrade to safety. The enemy were 25 to 30 strong and the attack failed despite these gallant efforts. Hedderman covered the withdrawal, firing until all others had gone. On 30th March a patrol found Mairoka clear of the enemy and on 4th April Lieutenant Gordon's platoon established a patrol base there. On the 7th Errey's platoon attacked a village to the east of the Milak villages but without success, Lieutenant Errey being killed, and Sergeant Layfield wounded. Chicanambu was occupied on the 9th. On April 15, two companies from the 2/6th pushed eastward towards the Screw River. Over the next five days, they faced strong opposition as they engaged in fierce skirmishes and patrol actions to secure critical territories, ultimately capturing Wambak, Kombichagi, and Bungara. Each of these locations represented not only strategic advantages but also a deepening impact on the local population and the broader campaign dynamics. On April 15, 1945, the 2/7th Battalion launched its main assault, with one company advancing towards the line of Nimrod Creek. This location, nestled within the dense jungles of New Guinea, proved to be strategically significant yet perilous. As they approached, Australian troops encountered heavily defended and camouflaged pillboxes, fortifications designed to protect the Japanese troops stationed in the area. Despite the challenges, they managed to secure a long, kunai-covered spur to the northeast of a critical area known as Maprik 2 by the following day. On April 17, another company from the 2/7th continued the offensive, advancing toward a target referred to as Maprik 1. They reached a point approximately 400 yards northwest of the objective but soon found themselves in a precarious situation as they became surrounded on both flanks the next day. It was not until April 19 that they successfully broke through to the southwest, escaping their encirclement.   The House Tamboran feature, a prominent ridge north of Maprik 1, was finally secured on April 20. This strategic high ground was essential for controlling the surrounding terrain and allowing further advances in the area. The following day, the 2/7th began probing towards the Maprik airstrip and Bainyik. Their efforts to secure the airstrip were fruitful within the next few days; however, they faced staunch resistance at both Maprik 2 and Bainyik, where Japanese forces continued to mount a determined defense. On April 25, the Australians crossed the Screw River, a vital waterway that flows through this region, on their way toward Midpum Creek, which they reached the following day. This movement was crucial for maintaining momentum in the campaign. While the 2/7th Battalion was engaged in heavy fighting, patrols from the 2/6th Battalion successfully secured the Neligum villages, although they encountered strong Japanese resistance at Mangumbu. This locality, bordered by lush vegetation and steep hills, served as a vital defensive position for Japanese forces. Simultaneously, intelligence reports about a small enemy contingent under Lieutenant-Colonel Takenaga Masaharu positioned at Tau prompted a swift response. On April 16, a platoon from the 2/5th Battalion departed from Aitape, a coastal town known for its strategic significance during the campaign. They tracked down the Japanese troops and engaged them at Kubriwat on April 24. After the Kubriwat engagement, Colonel Takenaga's troops managed to shake off pursuit by the Australians; yet as the Australians continued to harass them, Takenaga ultimately decided that they would surrender. They took a leaflet containing a notice of surrender that one of the soldiers had been carrying, added some conditions underneath in English, tied it to a pole for the Australians to find, and left the area. Scouts from Miles' platoon then found the leaflet and brought it back with them. On May 2, the Australian platoon spotted Takenaga's unit near Womgrer village, and asked a native to help them make contact. Two truce bearers from the Japanese side came to the Australians to negotiate, and on the following day Takenaga's unit surrendered at Womgrer and were disarmed. At the time of surrender, Takenaga's unit consisted of 42 men: five officers (including Takenaga), four warrant officers, and 33 non-commissioned officers and soldiers. They were equipped with five light machine guns, 17 rifles, five pistols, and 750 rounds of ammunition. The prisoners, escorted by Miles' platoon, marched for three days in an orderly fashion to Maprik Airport, and were then transported to Aitape. Takenaga's unit were held in Aitape for around one month, before being broken up and sent to prison camps in Lae and in Australia, where they received good treatment. They were all interrogated, and in particular, Takenaga was transported to Manila for a detailed interrogation. As well as giving character information about the commanders of the 18th Army, Takenaga gave his opinion of how the Allies should deal with Emperor Hirohito: "If the Emperor is killed then the Japanese people will resist until the bitter end, but if there is an order from the Emperor then they will probably surrender peacefully." Back in the Maprik sector, while Hayforce conducted probing operations and successfully captured Yentagim in early May, the Miyake Force began a withdrawal toward the Loanim-Yamil-Kumbungua line. This defensive line was a series of natural features and fortified positions designed to obstruct the advancing Australian troops. On the northern flank, the 2/6th Battalion also continued to patrol eastward, successfully securing the strategically important Mangumbu on May 2. This advancement not only disrupted enemy operations but also paved the way for further Australian advances in the region. On May 8, 1945, the 2/7th Battalion launched a decisive attack, successfully capturing part of the Kumbungua Ridge, a strategically significant high ground dominating the surrounding terrain. Two flame-throwers had now been received by the 2/7th and on 8th May these were used to drive the enemy from part of the narrow steep-sided Kumbungua ridge. The Japanese made off, abandoning 30 weapon-pits, but engaged the Australians from a knoll farther up the ridge. Just three days later, they captured the southern end of the ridge while another company moved to occupy Waigakum 1, a forward position that offered a crucial vantage point over the area. Flame-throwers were proving very effective. On 10th May the 2/7th occupied Waigakum 1, and on the 11th a platoon with flame-throwers attacked and took a position where the defenders abandoned 50 packs. Another platoon approached the knoll at the south end of the Kumbungua ridge from the south, attacked up a steep slope and put to flight the defenders who abandoned 25 packs and 100 sticks of gelignite. The Japanese opened fire, however, from higher up and, the ground being unsuitable for defence, the platoon withdrew. By May 13, following effective air support that softened enemy defenses, central Kumbungua was found abandoned by Japanese forces, a testament to the pressure the Australians had applied. The following day, after another heavy bombardment from both aircraft and artillery, the entire ridge was finally secured, marking a significant accomplishment in the campaign. Pressing on, the Australians cleared the area northeast of Kalabu by May 26. However, they faced stiff resistance and found it challenging to make further advances. As a result, the 2/7th Battalion reorganized to defend the captured positions, consolidating their gains to ensure they could withstand potential counterattacks from the tenacious enemy. In the meantime, on May 17, Waigakum 2 fell to Australian troops. This success forced the cutoff remnants of General Mano's 41st Division to begin their retreat to the east, as the Australians patrolled further towards Malba, another critical location along their advance. The loss of Waigakum to the 2/7th Battalion in mid-May had a very upsetting effect on the Japanese. It was the point of junction between Miyake Force, now 800 strong, and the 41st Division and, according to General Yoshiwara, this loss led directly to the withdrawal from Kalabu and Loanim. On the 19th a platoon, guided by natives, surprised six Japanese in a garden south-east of Kalabu. Here Private Jenkins" came upon one Japanese asleep outside a weapon-pit. As he was within feet of me (wrote Jenkins later) I thought it was an excellent opportunity to take a prisoner so I woke him with a light kick and pulled him to his feet with my left hand, keeping my Owen gun in my right. I had managed to get my prisoner some paces from his position when a slight noise alerted his mates and they opened fire on the patrol. With this the Jap broke from my grasp and I was forced to shoot him. One other Japanese was killed and the others made off.Turning their attention northward, the 2/6th Battalion attempted to attack the village of Jamei on May 20. However, they were met with fierce resistance from Japanese defenders, which compelled the Australians to bombard the area intensively with artillery and air strikes until the enemy was finally forced to retreat on May 25. While the Australians were continuing to probe towards Yamil, elements of the 2/7th Battalion executed successful attacks in the Malba area, which was ultimately secured by the end of the month. This marked a crucial step in their advance as they pushed deeper into enemy territory. Meanwhile, in the coastal sector, Brigadier King's 16th Brigade concentrated its efforts east of the But River, extending up to the Kofi area. At the same time, Brigadier Martin's 29th Brigade assembled at But, preparing for the final drive toward Wewak, a town that had become a strategic target for Allied forces in their campaign to eradicate Japanese presence in New Guinea. On April 14, the 2/1st Battalion passed through the lines of the 2/2nd Battalion, launching an attack toward the Karawop-Wisling area. This sector, known for its rugged topography and dense underbrush, finally fell to the relentless Australian assaults two days later after a series of intense company-level attacks. On April 25, the 2/1st Battalion occupied the crucial 1800 Feature without facing any opposition. This high ground provided them with significant tactical advantages in the ongoing conflict. Meanwhile, the 2/3rd Battalion, positioned to the north, successfully launched an attack on Boiken Plantation. Their efforts were rewarded as they advanced to Kalimboa the following day, further consolidating Australian positions in the region. On April 27, 1945, the 2/2nd Battalion moved swiftly through the advancing lines, pushing forward to Hawain and crossing the river in their quest to engage Japanese forces. Concurrently, the 2/3rd Battalion patrolled south along Boiken Creek, where they encountered significant enemy resistance in the Koanumbo area. After a series of determined assaults, this area was ultimately secured by May 2, allowing the Australians to fortify their positions. At this point in the campaign, Brigadier Martin's 19th Brigade took over the advance towards Cape Wom, and subsequently, the strategic objective of Wewak. This movement coincided with preparations by Lieutenant-Colonel Eric Hennessy's 2/6th Commando Regiment, which was organizing for a surprise landing east of Cape Moem, a critical maneuver aimed at outflanking Japanese defenses. On May 3, the 2/4th Battalion advanced from Hawain, managing to cover six miles without facing any opposition. By the next day, they reached Wom without incident. As night fell, Australian patrols had already established a presence along the Waringe River, preparing for further actions. During this time, patrols targeted Japanese stragglers in the vicinity, eliminating several and gathering intelligence. Reconnaissance units were then sent forward to Minga Creek to assess enemy positions while the 2/4th secured Yarabos on May 7, progressively tightening the noose around Japanese defenses. Meanwhile, the 2/8th Battalion, positioned on the right flank, engaged in a series of minor clashes, successfully capturing Ranimboa on May 4, followed by Numikim just days later. These advances were crucial in pressuring the remaining Japanese forces, which, under Generals Adachi and Nakano, were increasingly evident in their abandonment of the substantial base at Wewak. Their main forces began to withdraw over the rugged terrain of the Prince Alexander Mountains, leaving behind strong rearguards tasked with covering their exit routes from Wewak. To counter this withdrawal, the 2/11th Battalion and the 2/7th Commando Squadron were dispatched on a wide encircling movement towards the Sauri villages and Wirui Mission, aiming to cut off the retreating Japanese forces. Meanwhile, the 2/4th Battalion crossed Minga Creek and launched an attack towards Wewak on May 8, seeking to claim the final strategic stronghold. Two days later, bolstered by supporting tanks and artillery, the 2/4th Battalion initiated a vigorous assault on Wewak Point. This area, positioned at the very tip of the peninsula, was essential for controlling the coastal approaches to Wewak. After a hard-fought engagement, the Australians successfully seized the entirety of Wewak Point, subsequently mopping up the remaining Japanese soldiers who had entrenched themselves in the caves along the cliffs, effectively concluding the intense fighting in this region. At 12.15 two companies were ordered to mop up.cThat afternoon a flame-thrower fired into a bunker apparently lit a dump of bombs which blew up. Smith's company found several occupied caves and, since the Japanese would not surrender, merely picqueted them until engineers arrived and blew up the entrances, sealing the Japanese in. It was estimated that about 50 perished in the caves; by midnight 65 other dead had been counted and three 75-mm guns and two 20-mm had been captured. In a brilliant action the Australians, supported by tanks and more than 40 field guns, had lost only 2 killed and 17 wounded. Mopping up was continued next day, and no live Japanese remained on the point by midday. Finally it was estimated that from 180 to 200 Japanese had been killed. On May 11, 1945, following their progress along the Big Road, the 2/11th Battalion set out to occupy the strategic 620, 710, and 770 Features. However, they soon encountered unexpected resistance over the following days. This was not merely an isolated skirmish; it was part of a broader engagement as they pressed their advance against the entrenched Japanese defenders. Meanwhile, an important operation was unfolding to the west. The 2/9th and 2/10th Commando Squadrons, supported by a small flotilla formed around the sloop Swan, successfully landed on Dove Bay's Red Beach, located just to the west of Forok Point. This maneuver was critical, as it disrupted Japanese supply lines and provided the Australians with a foothold to cut off the Wewak Road. Following their landing, the squadrons dispatched patrols eastward, further isolating Japanese forces. The next day, the 2/3rd Machine-Gun Battalion secured the junction of the Wewak Road and Forok Creek, a key point for controlling the surrounding areas, while the 2/9th Commando Squadron patrolled past Mandi, gaining valuable intelligence. The 2/4th Battalion, capitalizing on this chaos, pressed forward to secure the Wewak airfield and the Wirui Mission, both of which were vital for maintaining air support and supply routes in the theater of operations. On May 13, the 2/11th Battalion successfully captured the 620 Feature, a crucial hill that provided vantage points over the battlefield. However, they struggled to take the 710 Feature the next day, as Japanese resistance intensified in the rugged foothills south of the Big Road.  On 14th May, the 2/11th being heavily engaged in the foothills south of the Big Road, Lt Martin had ordered the 2/4th to attack Wirui Mission, which was on a steep kunai-covered hill about 300 feet high dominating the airfield. Approaching from the east through tall kunai the leading com-pany with a troop of tanks soon took the first objective-dominating ground about half way up the hill. Captain Smith's company passed through and, with the tanks, whose crews estimated that they killed about 30 Japanese, reached the top. By nightfall the top and the eastern slopes were held but the Japanese were fighting back from bunkers on the north-west slopes. Next day Smith's company attacked these remaining bunkers. The lead-ing section was halted by intense fire after several men had been hit. Private Kenna, in the supporting section, which was firing on the bunkers at a range of only 50 yards, stood up in the kunai grass in full view of the enemy and fired his Bren at one of the Japanese machine-gun posts. The Japanese machine-gunners returned his fire but failed to hit him. Kenna then said to Private Rau who was beside him that the Japanese "had a bead on him" and he asked for Rau's rifle. Still standing, he fired four rifle shots and silenced the enemy post. He then took the Bren again and opened fire on another post about 70 yards away and silenced it too. The remaining post was then knocked out by a tank; soon the 2/4th and 2/11th were in contact. About 40 Japanese were killed and perhaps 20 escaped in the fight for the mission. Large quantities of weapons, vehicles, generators, tele-phones and other equipment were found there. Possession of Wirui Mission gave complete control of the Wewak coastal plain. Captured papers made it possible to make a fairly precise estimate of the forces immediately round Wewak: Kato Force, built round the 25th Airfield Battalion and about 300 strong, was holding from Sauri to Wirui Creek; Jinka Force, about 400 strong, was holding from Wirui Creek to the east, including Boram airfield, and south into the range as far as Passam; to the east was Aoyama Force, of unknown strength; the coastal plain to a depth of about 1,000 yards was not held in strength, and it was thought that there would be little opposition on the coast at least as far as Boram airfield Supported by artillery fire and through persistent efforts, the 2/11th finally took the 710 Feature on May 15, which allowed them to begin patrolling towards the 770 Feature and the nearby Klewalin, two additional strongholds that were key to the entire operation. Simultaneously, since May 11, the 2/7th Commando Squadron had been engaged in fierce fighting. They maneuvered through a series of knolls in the Sauri villages area, which they ultimately cleared by May 16, further tightening the noose around Japanese defenses. On that same day, after intense air and naval bombardments prepared the way, the 2/8th Battalion began their advance toward Boram. This crucial location fell into their hands unopposed by nightfall, allowing significant advances in the Australian front line. However, on May 17, as the 2/8th Battalion continued its push to the mouth of Boram Creek, they encountered a strongly-held Japanese position. This area, characterized by intricate terrain and dense jungle cover, presented formidable challenges as they sought to advance further into Japanese-occupied territory. The enemy bunkers would remain a formidable obstacle until May 20, when a heavy bombardment finally rendered them inoperative. Following this, the Australians seized the opportunity to exploit their gains and advanced further east to occupy Cape Moem. This maneuver allowed them to establish contact with the commando force at Brandi Plantation just two days later, strengthening their foothold along the coast. On May 24, the 2/11th Battalion occupied the strategic 770 feature after enduring its own heavy bombardment. Three days later, they managed to destroy the last remnants of enemy forces south of the 710 feature, marking a significant step in the campaign. On May 25, the 2/4th Battalion also launched a patrol into the village of Koigin, taking the location after a sharp and intense fight. However, amidst these operations, Brigadier Martin fell ill with malaria and was temporarily replaced by Lieutenant-Colonel John Bishop, a shift that would guide the troops through the operational challenges ahead. By the end of May, the 6th Division had pushed most remnants of the Japanese 18th Army away from the coast, including their vital base at Wewak. The Japanese forces were now confined within the rugged, mountainous terrain, squeezed between the 17th Brigade, positioned forward of Maprik to the west, and the remainder of the 6th Division to the north. In preparation for the next phase of their campaign, General Moten set out to secure the line from Solongan to Kulauru Mission. The 2/5th Battalion relieved the 2/7th Battalion and moved against Kulauru and Ulupu, while the 2/6th Battalion advanced towards Yamil. The Australians acted swiftly and decisively, rapidly capturing Newton's Knoll and Palketia during the first week of June. On June 10, after extensive air strikes and bombardments weakened enemy defenses, the 2/6th Battalion successfully entered Yamil. Just three days later, on June 13, the 2/5th Battalion continued their momentum by capturing Yamil 3 and Yuman as the beleaguered Miyake Force began its retreat towards Ulupu, indicating the deteriorating situation for Japanese forces in the region. Despite the Australians' relentless advance and the heavy bombardment inflicted upon them, the Japanese remained determined to defend Kunai Spur. Their tenacity meant that the Australians could only secure Yamil 4 on June 24, underscoring the intensity of the fighting in this strategic area. At this critical juncture, the 2nd New Guinea Battalion arrived in the Hayfield area to patrol southwards towards Kwimbu, Mikau, and Kunjinge. These movements further reinforced the Australian positions and set the stage for the continuing efforts to dismantle the last remnants of Japanese resistance in the region. On June 11, 1945, the 2/8th Battalion successfully seized Hill 1 after a concentrated air and artillery bombardment that softened up the enemy defenses. This pivotal victory allowed them to establish a critical foothold in the area, vital for subsequent operations. Just five days later, on June 16, both artillery and aircraft targeted Hill 2 and Shiburangu, two crucial positions that had become points of interest in the ongoing campaign. After numerous attempts and repeated efforts by the infantry, the Australians ultimately captured Hill 2, a strategic vantage point that further pressured Japanese forces in the region.At 8 a.m. on 16th June aircraft struck both Hill 2 and Shiburangu and then the artillery began a program in which 3,000 rounds were fired. One company began to advance on Hill 2 at 9.30. Warrant-Officer Fisk's platoon, which was forward, met heavy fire from snipers on both flanks and machine-gun fire from the hills and lost one man killed and one wounded. It withdrew to the cover of the spur and moved to outflank the enemy on the left. Meanwhile at 9.45 a second company had taken the pocket without opposition. At 10 a.m. the first company was still held. The men rested under the lip of the hill while the artillery again bombarded the enemy's positions and flame-throwers were brought forward. At 1.30 the company surged over the crest of the hill and, after close fighting in which each bunker was grenaded, the surviving Japanese fled leaving 38 visible dead and perhaps another 20 buried by the air and artillery bombardment. The Australians lost 2 killed and 3 wounded. "Aerial bombing coupled with artillery concentration does not deter the enemy from fighting nor unsettle him unduly," wrote the battalion diarist. "Such fanatical resistance in face of such odds makes the capturing of these strong points no light task." Meanwhile, the 2/4th Battalion worked diligently to clear the eastern side of the Koigin-Tazaki track, progressing 600 yards south of Koigin by June 13. This advancement helped secure vital supply routes and reinforced the Australians' operational capabilities. On June 14, the Australians continued their momentum by successfully securing Mount Kawakubo, another significant terrain feature. Five days later, on June 19, the 2/4th and 2/11th Battalions launched a coordinated attack towards Tazaki. Thanks to the overwhelming support of air and artillery bombardments, Tazaki ultimately fell into Australian hands by June 24, marking yet another victory in their relentless push against Japanese defenses. On June 22, the 2/8th captured the last knoll before Shiburangu. Following this success, artillery began to register targets on Shiburangu, setting the stage for a significant assault. By June 27, after a particularly heavy air and artillery bombardment that saturated the area with firepower, the 2/8th Battalion launched a bold attack to seize Shiburangu. Utilizing an outflanking maneuver, they managed to surprise the fierce defenders, overcoming their determined resistance. As the 2/4th Battalion cleared the remaining enemy pockets in the Tazaki area, the 2/8th Battalion pressed their advantage, attacking and securing the area to the west on July 3. The two battalions effectively linked up two days later, solidifying their control over the region and paving the way for further advances in the campaign. Looking back to the southwest, after nearly three weeks of stiff resistance, the Japanese finally abandoned Kunai Spur on July 3, 1945. This withdrawal opened the door for Australian forces, who swiftly occupied Ulupu just two days later. The effort to clear the surrounding area began in earnest, but it wasn't until July 8 that the strongly-held northern knoll was taken after intense fighting. On July 9, through a sustained bombardment, the Japanese were driven out of Ulum, marking a significant breakthrough; their defense system had been shattered. Following this success, patrols from the 2/5th Battalion advanced rapidly, moving forward about 2000 yards with only minor skirmishes. They reached and occupied Kulauru Mission on July 11, reinforcing the Australians' control over the area. Pressing northeast, the remaining Japanese forces in the vicinity were rapidly dispersed, and by July 18, Ilipem fell into Australian hands. During this time, the 2/6th Battalion was busy securing the Ulunkohoitu Ridge, further consolidating the Australians' hold on the region. At the same time, the 2nd New Guinea Battalion had been probing south and east, successfully securing critical locations such as Kongambe, Kwandaning, Naila, and Gisanambu. With the Japanese now regrouping along the Kaboibus-Ahegulim-Gwalip line, General Moten aimed to accelerate the advance, directing both the 2nd New Guinea Battalion and the rested 2/7th Battalion to converge on Gwalip. Meanwhile, the 2/5th and 2/6th Battalions pressed east towards Kaboibus. Despite facing challenges and some failed attacks against Dunbit and Aoniaru, the New Guineans were able to concentrate their forces near Gwalip by July 22, and five days later, Sigora fell to their determined assault. On July 30, they launched an attack and captured Ulama, nearly catching General Mano's headquarters at Winge in the process, which forced the defenders to retreat towards Suaui. As momentum continued to build, the 2/5th Battalion pressed on, supported by heavy air strikes. By August 1, they had successfully taken Gwenik, further disrupting Japanese lines. The following day, as the Australians advanced along the Kaboibus Ridge, they successfully occupied the Kaboibus villages. To their astonishment, they encountered only minor opposition, underscoring the disarray within the Japanese ranks as the Australians continued their relentless push through the region. On August 4, 1945, the 2/5th Battalion successfully seized Ahegulim, a strategic location that added to their momentum. Three days later, they captured Malabeim, completing their objectives in the region. Following this success, the Australians began probing towards Mount Irup, further extending their influence over the landscape. Concurrently, on August 6, the 2/7th Battalion embarked on a wide movement from Sigora aimed at Kiarivu, reaching this target two days later. This advance was part of a broader campaign in which New Guinean troops also secured key areas such as Miyamboara and Mananingi, reflecting the persistent efforts of Moten's 17th Brigade as they conducted their final offensive actions. Turning to the eastern front, the 8th Brigade's 30th and 35th Battalions had relieved the 2/4th and 2/11th Battalions in early July, taking charge of the Wirui Creek-Mandi area. On July 13, Brigadier Martin, who had resumed command of the 19th Brigade, ordered the 2/8th Battalion to capture the critical positions known as The Blot and Hambrauri. Following this directive, the Australians successfully attacked and seized The Blot the very next day. On July 16, Hambrauri 1 fell into Australian hands without opposition, allowing them to begin probing towards another strategically important feature: St. Patrick's. After significant preparations and a heavy bombardment, St. Patrick's was captured on July 21. The following day, the 2/8th Battalion captured Hambrauri 2 with little resistance, showcasing their growing operational effectiveness. During this time, the 2/1st Battalion executed a diversionary thrust along the Sambukaua Track, drawing Japanese attention away from main Australian advances. Simultaneously, the 2/6th Commando Regiment faced daring infiltration attempts to the west in the vicinity of Boiken, further complicating the operational landscape.  On June 24 five Japanese approaching along the beach entered the Angau compound at Wisling, stole 3 Owen guns, a pistol, and 3 Japanese rifles. A patrol followed these marauders, killed 2 and retrieved the weapons. Next day about 10 Japanese ambushed a party of the 2/10th Commando Squadron south of Boiken Plantation and killed Lieutenant Martin and wounded 4 others; and that night about 20 stole into the plantation. On June 28 signs were found that some 35 Japanese had slept the previous night 400 yards from a commando perimeter. On July 23 a commando patrol had a sharp clash with perhaps 40 Japanese in the hills south of Wanpea and more than 15 miles west of Wewak; 8 Japanese were killed as well as 4 Australians. The Japanese were justly proud of the valour and successes of the raiding parties which harassed the Australians between Wewak and Dagua in May, June and July. Several groups were organised and trained for these enterprises, the most celebrated being led by Lieutenant Saito Hachiro of the 78th Regiment who had first earned fame as a patrol leader in the Huon Peninsula fighting. In June his party set off to raid Maprik, but was intercepted, Saito and most of his followers being killed. From June 15 onwards two parties of raiders operated in the Karawop and Boiken areas with the object of diverting their enemy's strength away from the 51st Division farther east. These parties, which claimed to have killed more than 100 Australians (a wild overestimate) were the ones coped with by the 2/6th Commando Regiment. Another series of raids in late July and early August were considered less successful, because of improved Australian security measures. On July 25, Japanese General Adachi issued orders for a "last stand" around the areas of Nyakombi and Sassuia. The main body of the 18th Army was now in an are facing north and west. The 51st Division was on the right opposing the troops advancing from Wewak, the 20th Division in the centre and the 41st on the left. Yoshiwara had now reported that the food resources of the Sepik area were less than had been believed, though there might be more in the hinterland. Already about 2,800 troops were stationed in the Sepik Valley from Marienberg to about Kanganaman and were living off the country. Adachi decided to make a last stand in the area embracing, in the north, Nyakombi and Sassuia. Here they would fight on "as long as ammunition and food are available and at least until the end of September". Liaison was to be maintained with the force in the Sepik area which was to prepare to carry on "ambush warfare" after the main force had been wiped out. This plan had been conveyed to Field Marshal Terauchi, commanding the Southern Army, and he approved it on 8th July. Despite its many setbacks during the campaign, Terauchi sent a citation to the 18th Army. It was the first time that a Japanese army had been so honoured. The citation ran: "To the 18th Army and all attached units: With Lieut-General Hatazo Adachi as your com-mander, you have fought vigorously for three years in north-east New Guinea, where numerous epidemics prevailed and where the terrain was hitherto unknown to any Japanese. When the enemy occupied the west coast in April 1944, to cut off supplies, you learned to live off grass and trees, and by making the best of the situation, you conquered all unfavourable conditions. Officers and soldiers alike displayed the true spirit of the Japanese Army. Wherever you encountered the enemy, you crushed them and inflicted many casualties. You have inspired fear into the hearts of the enemy and diverted their sea and air strength, thereby contributing much to the Southern Army's operations and furthermore, to all the Armies of the Empire. You were able to accomplish this through the excellent leadership, planning, fidelity and character of your Army Commander. By the sense of sincerity, loyalty and moral obligation of all the troops, you have set a model for all men to follow. I hereby present this citation and proclaim this to all the Armies."  Amidst these developments, Major General Stevens was orchestrating a series of troop reliefs along the front lines. King's 16th Brigade was set to replace the 19th Brigade, which in turn would relieve the 17th Brigade to the west, ensuring continuous pressure on Japanese positions while maintaining the momentum of the Australian advance. Consequently, on July 28, 1945, the 2/2nd Battalion relieved the 2/8th in the Hambrauri area, immediately dispatching patrols to probe towards Numoikum. Their operational efforts culminated in the successful seizure of Mount Shoto on August 2. By August 6, with the backing of artillery fire, the Australians had secured Numoikum and Rindogim. However, this marked the last offensive action in the area, as the Australians shifted their focus to patrolling forward in order to consolidate their gains. By the end of the Aitape-Wewak Campaign, the 6th Division had sustained significant casualties, with 442 men killed and 1,141 wounded, while inflicting heavy losses on Japanese forces, estimated at around 9,000 killed and capturing 269 prisoners. With this chapter closed, it was time to shift the scene to Balikpapan, where the conclusion of the Borneo Campaign awaited. As we rejoin the action, by July 9, General Milford's 7th Australian Division had largely secured the Balikpapan area. Brigadier Chilton's 18th Brigade executed a successful landing at Penadjam, Djinabora, and Teloktebang on the western side of the bay. Simultaneously, Brigadier Eather's 25th Brigade advanced towards Batuchampar along Milford Highway, while Brigadier Dougherty's 21st Brigade secured key positions in the Sepinggang and Manggar areas. On July 10, the 2/31st Battalion secured the Cello position and the fallen-timber area directly in front with crucial support from artillery and tanks. In a bold move, one of their companies launched an attack towards the position known as Coke; however, this assault was met with fierce resistance and was ultimately repelled by intense crossfire from well-entrenched defenders. To the left of their advance, the 2/6th Commando Squadron probed toward Sumber Kiri, successfully securing the village and bolstering the Australians' hold in the region. At this moment, the 2/27th Battalion took over the left flank at Manggar, which allowed the exhausted 2/14th Battalion to probe towards Sambodja without risk of being outflanked. The next day, as the 2/27th moved through the 2/14th to occupy Lamaru, the 2/25th Battalion began the process of relieving the weary 2/31st, ensuring that fresh forces could continue the advance. On July 12, the commandos initiated probing operations towards a position known as Charm, successfully occupying both Cloncurry and Abash in the following two days. These captures were significant in securing the area and maintaining the momentum of the Australian advance through Balikpapan. After extensive patrolling on both sides of the highway, the 2/25th Battalion finally dispatched two companies on July 14 to occupy the strategic locations of Cart and Calm. These efforts led to the successful securing of Cocoa, Calm, and Chair, all achieved without resistance. That same day, to the east, patrols discovered Amborawang and the ridges north of Bale unoccupied. Recognizing this opportunity, the 2/27th Battalion moved into the area three days later. On July 15, the 2/9th Battalion sent patrols towards Separi and along the Parehpareh River, aiming to cut the enemy's lines of communication. Concurrently, the 2/25th Battalion solidified its control over Cart, enabling them to dominate the highway from both the east and west. However, their position was soon contested as they faced a series of heavy Japanese counterattacks during the following nights, testing their resolve and defensive capabilities. By July 17, the 2/25th had moved to occupy Charm, situated prominently by the highway, while a company from the 2/33rd Battalion took over Cart, allowing both units to repel yet another strong night counterattack from Japanese forces. The next day, the 2/27th finally entered the unoccupied Sambodja area, while patrols began to probe westward toward the Milford Highway. On July 19, the 2/31st Battalion cleared the last remnants of Japanese presence from the highway, paving the way for uninterrupted Australian operations. The following day, the 2/25th destroyed a robust enemy pocket, allowing them to occupy Abide without further incident. On July 21, the remaining Japanese forces retreated from the Batuchampar area, prompting the Australians to push toward Pope's Track while extensively patrolling northward. By this time, the bulk of the 2/1st Pioneer Battalion had been landed at Djinabora, establishing a patrol base in the Tempadung area. A week later, following a naval bombardment, the Australians occupied Pamaluan and began probing operations to the east and north. This series of actions marked the conclusion of the Battle of Balikpapan. The Australians opted to halt any offensive operations at this point and instead focus on consolidating their positions through enhanced patrolling. During the course of the battle, Australian forces tragically suffered 229 killed and 634 wounded, while inflicting significant losses on the Japanese, with approximately 2,032 killed and 63 captured. Thus, Australian casualties for the broader Borneo Campaign totaled around 2,100, while Japanese losses were estimated at around 4,700. I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. General George Stevens led brave troops against the entrenched Japanese forces aiming to capture the strategic town of Wewak. Despite fierce resistance and rugged terrain, they successfully advanced, featuring key victories after relentless battles. Australian artillery and infantry engaged in daring assaults, securing vital positions like the Kumbungua Ridge and establishing airfields. As the campaign progressed, Japanese forces dwindled, ultimately surrendering at Wewak. 

For Patrick Ta Beauty, the key to growth isn't just great marketing — it's an experience that educates, inspires and converts.In this episode of Retail Remix, host Nicole Silberstein chats with Heidi Lim, VP of Ecommerce at Patrick Ta Beauty. With experience leading digital growth at brands like ThirdLove, Estée Lauder and Fashion Nova, Heidi shares how she's now helping Patrick Ta Beauty stand out in the crowded, trend-driven beauty market. From breaking through the noise on TikTok to building smarter marketing flows, she reveals what it really takes to scale a prestige beauty brand today.Together, they discuss:How the brand turns product education into a powerful driver of conversion and trust;Why a diversified channel mix — DTC, Sephora, TikTok Shop — is key to building both reach and resilience;What makes creator partnerships work — and how to keep them aligned with your brand story;How the team achieved 8X year-over-year growth during BFCM by doubling down on retention;PLUS the beauty trend you'll be hearing about all summer. RELATED LINKSExplore Patrick Ta Beauty's latest products and digital experiencesRead more about ecommerce innovation at Retail TouchPointsCheck out past episodes of Retail Remix

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- 导语 - 长期以来，药物研发的公平性议题备受社会关注。丁胜博士在制药领域深耕多年，从研究干细胞领域拓展至创建多家生物技术公司。2015年，丁胜选择回国筹建清华药学院，次年创办全球健康药物研发中心（GHDDI），通过这一公益性的新药研发中心，支持全球健康和发展目标的实现。为什么疟疾、结核病等传染病是“被忽视的疾病”？青蒿素问世后，抗疟药物为何仍需经历多次迭代升级？人工智能技术如何辅助药物研发？面对抗癌天价药，如何在创新激励与药品可及性之间寻求平衡？请听本期嘉宾丁胜带来的精彩分享。 - 本期话题成员 - 程衍樑（微博@GrenadierGuard2） 丁胜，全球健康药物研发中心主任，清华大学药学院首任院长、拜耳特聘教授。 - 时间轴 - 01:17 丁胜师从加州生物医学研究所创始人彼得·舒尔茨 03:31 美国医药研究与大型药物研发公司的人才流通 05:11 作为共同创始人，参与创建多家生物技术公司 09:47 百万一针、非「现货型」：CAR-T疗法治疗癌症的局限性 16:36 从创业者到院长：回国筹建清华药学院及创办GHDDI 21:21 清华药学院专注上游科研，GHDDI攻坚下游药物创新 23:22 专攻「穷病」：疟疾与结核的药物研发为何被忽视 29:03 青蒿素之后，抗疟药为何仍需升级？ 33:23 「创新药物的平均成功率不到10%」 34:21 新冠让抗病毒药物研发成为新重点 36:07 从大模型到智能体，AI怎么帮助研发新药？ 39:39 ChatGPT创始人Sam Altman投资丁胜参与创办的抗衰公司 46:21 天价药困境：创新与公平的定价平衡难题 - 本期术语 - GHDDI（Global Health Drug Discovery Institute） 全球健康药物研发中心于2016年在北京成立，是由清华大学、北京市政府和盖茨基金会联合创办的一所独立运营、非营利性质的创新药物研发机构。 CAR-T疗法（Chimeric Antigen receptor T cells） 嵌合抗原受体T细胞免疫疗法，近年来兴起的一种治疗肿瘤的精准靶向疗法。 TSRI（The Scripps Research Institute） 斯克利普斯研究所，一所私立的非营利性的生物医学研究机构。 Calibr（California Institute for Biomedical Research） 加州生物医学研究所，一家独立的非营利机构，成立于 2012 年，旨在加速基础研究向新药的转化，以解决尚未满足的医疗需求。 NiV（尼帕病毒） 亨尼巴病毒属的一种RNA病毒，通常在特定种类的果蝠之间传播。 - 制作团队 - 声音设计 hotair 节目统筹 禾放 节目运营 小米粒 节目制作 hualun 思钊 Yo logo设计 杨文骥 - 音乐 - Danse Macabre - Busy Strings - Kevin MacLeod - 本节目由JustPod出品 © 2025 上海斛律网络科技有限公司 - - 互动方式 - 商务合作：ad@justpod.fm 微博：@忽左忽右leftright @播客一下 @JustPod 微信公众号：忽左忽右Leftright / JustPod / 播客一下 小红书：JustPod气氛组 / 忽左忽右 B站：忽左忽右leftright 抖音：忽左忽右

- 导语 -长期以来，药物研发的公平性议题备受社会关注。丁胜博士在制药领域深耕多年，从研究干细胞领域拓展至创建多家生物技术公司。2015年，丁胜选择回国筹建清华药学院，次年创办全球健康药物研发中心（GHDDI），通过这一公益性的新药研发中心，支持全球健康和发展目标的实现。为什么疟疾、结核病等传染病是“被忽视的疾病”？青蒿素问世后，抗疟药物为何仍需经历多次迭代升级？人工智能技术如何辅助药物研发？面对抗癌天价药，如何在创新激励与药品可及性之间寻求平衡？请听本期嘉宾丁胜带来的精彩分享。- 本期话题成员 -程衍樑（微博@GrenadierGuard2）丁胜，全球健康药物研发中心主任，清华大学药学院首任院长、拜耳特聘教授。- 时间轴 -01:17 丁胜师从加州生物医学研究所创始人彼得·舒尔茨03:31 美国医药研究与大型药物研发公司的人才流通05:11 作为共同创始人，参与创建多家生物技术公司09:47 百万一针、非「现货型」：CAR-T疗法治疗癌症的局限性16:36 从创业者到院长：回国筹建清华药学院及创办GHDDI21:21 清华药学院专注上游科研，GHDDI攻坚下游药物创新23:22 专攻「穷病」：疟疾与结核的药物研发为何被忽视29:03 青蒿素之后，抗疟药为何仍需升级？33:23 「创新药物的平均成功率不到10%」34:21 新冠让抗病毒药物研发成为新重点36:07 从大模型到智能体，AI怎么帮助研发新药？39:39 ChatGPT创始人Sam Altman投资丁胜参与创办的抗衰公司46:21 天价药困境：创新与公平的定价平衡难题- 本期术语 -GHDDI（Global Health Drug Discovery Institute）全球健康药物研发中心于2016年在北京成立，是由清华大学、北京市政府和盖茨基金会联合创办的一所独立运营、非营利性质的创新药物研发机构。CAR-T疗法（Chimeric Antigen receptor T cells）嵌合抗原受体T细胞免疫疗法，近年来兴起的一种治疗肿瘤的精准靶向疗法。TSRI（The Scripps Research Institute）斯克利普斯研究所，一所私立的非营利性的生物医学研究机构。Calibr（California Institute for Biomedical Research）加州生物医学研究所，一家独立的非营利机构，成立于 2012 年，旨在加速基础研究向新药的转化，以解决尚未满足的医疗需求。NiV（尼帕病毒）亨尼巴病毒属的一种RNA病毒，通常在特定种类的果蝠之间传播。- 制作团队 -声音设计 hotair节目统筹 禾放节目运营 小米粒节目制作 hualun 思钊 Yologo设计 杨文骥- 音乐 -Danse Macabre - Busy Strings - Kevin MacLeod- 本节目由JustPod出品 © 2025 上海斛律网络科技有限公司 -- 互动方式 -商务合作：ad@justpod.fm微博：@忽左忽右leftright @播客一下 @JustPod微信公众号：忽左忽右Leftright / JustPod / 播客一下小红书：JustPod气氛组 / 忽左忽右B站：忽左忽右leftright抖音：忽左忽右

Send us a textWork with Jordan personally at www.ecommerceos.coWork with social commerce club at www.socialcommerceclub.comGet 27 strategies in 27 days at https://socialcommerceclub.com/pages/27-strategiesJoin Tiktok shop elites mastermind at https://www.skool.com/tiktokshopelite/aboutUnlock the full potential of product bundles and transform your Shopify store into a high-performing sales machine! In this in-depth, step-by-step masterclass, Jordan West—serial e-commerce entrepreneur (7 brands and counting) and founder of Social Commerce Club—reveals his proven playbook for:Why Bundles WorkDiscover the psychology behind “story-selling” and decision fatigue. You'll learn how a well-framed bundle gives shoppers a clear “why” to buy—whether it's a Father's Day Grill Master Kit or a Self-Care Sunday Set—so they spend more without feeling overwhelmed by choice.6 Powerful Bundle Strategies• Preset Themed Bundles: Fixed-price collections ideal for gifting around holidays and special occasions.• Build-Your-Own Bundles: Let customers mix and match best-selling items to personalize their purchase and boost engagement.• Tiered Savings (Buy More, Save More): Encourages higher cart values with volume discounts—perfect for consumables like supplements.• Mystery Bundles: Move slow-selling inventory like magic by creating irresistible “grab bag” deals.• Subscription Bundles: Turn one-time buyers into loyal subscribers with curated recurring kits.• Seasonal or Event-Driven Bundles: Capitalize on upcoming events or trends with timely, limited-edition sets.Top Shopify Bundle AppsGet an honest comparison of the leading no-code solutions.Live Build DemoWatch over Jordan's shoulder as he installs Bundle Builder, creates a “Father's Day Grill Master Kit,” sets SKUs and pricing, syncs inventory, and adds persuasive “You Saved” messaging based on the Law of 100.Pro Tips & Best PracticesLaw of 100 Pricing: When your bundle total exceeds $100, showcase the dollar amount saved rather than a percentage to maximize impact.Lifestyle Photography: Sell the sizzle by showing your bundle in action—unboxing, gifting moments, or product-in-use scenarios.Inventory Sync: Avoid the most common pitfall—make sure your bundle app correctly deducts stock to prevent oversells.Abandoned-Bundle Flows: Leverage Klaviyo or other email triggers to recover potential lost revenue when someone adds a bundle but doesn't check out.Promotion HacksTreat your bundle like a brand-new product launch:Email Campaigns: Use gift-focused language, urgency (“Limited edition—only 50 kits left!”), and clear CTAs (“Add Grill Master Kit to Cart”).UGC & Paid Ads: Showcase real customers unboxing and using your bundle, targeted at gift-givers (e.g., “Make Dad's Day!”).Mini-Launch Events: Tease the bundle on social, run countdown timers, and partner with influencers to drive FOMO.Ready to scale without slashing prices? Whether you're just starting or you're a seasoned Shopify pro, this tutorial gives you the exact framework, tools, and tactics you need to build, launch, and profit from high-impact bundles today.

In this episode, Jonathan Sackier welcomes Claudio Cerchione, haematologist and researcher at the Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. From his early interest in plasma cell disorders, Cerchione shares key insights into the evolution of multiple myeloma (MM) research, the rising role of minimal residual disease (MRD), and promising developments in monoclonal antibodies and CAR-T therapy. He also reflects on standout moments from recent European Hematology Association (EHA) Congress and American Society of Clinical Oncology (ASCO) Annual Meeting, and shares his hopes for the future of haematology.   Timestamps: 2:14: Memorable career experiences for Claudio   4:20 Biggest breakthrough in MM  5:10 Interest in plasma cell disorders  6:30 A surprising fact about multiple myeloma  7:40 Claudio's top choice for a dinner party guest  10:30 The importance of MRD in haematology  13:00 Monoclonal antibodies and CAR-T therapies  19:00 Current challenges  22:22 Claudio's key EHA and ASCO takeaways  28:30 Claudio's three magic wishes  

Avec : Pierre Rondeau, économiste. Périco Légasse, journaliste. Et Emmanuelle Dancourt, journaliste indépendante. - Toujours accompagnée de Rémy Barret et sa bande, Estelle Denis s'invite à la table des français pour traiter des sujets qui font leur quotidien. Société, conso, actualité, débats, coup de gueule, coups de cœurs, sexo… En simultané sur RMC Story.

Jonathan Gluck is a writer whose powerful storytelling has been in The New York Times, The Washington Post, New York Magazine, and Vogue. He has served as deputy editor and managing editor of the New York Magazine. Over the course of his distinguished career, Jonathan has earned multiple National Magazine Awards. Now, he turns inward with his latest work, An Exercise in Uncertainty: A Memoir of Illness and Hope, a deeply personal account of his diagnosis with Multiple Myeloma—an incurable blood cancer—and the emotional and physical journey that followed.  In this episode, host Shay Beider speaks with Jonathan about his journey with the blood cancer he's lived with for over two decades. He shares what life looked like at the moment of his diagnosis, the emotional complexity of telling loved ones, and the guilt that often comes with being the one who is sick. The pair discuss how caregiving carries its own burdens and quiet heroism. Jonathan shares the details on promising innovative treatments like CAR-T cell therapy. Finally, he speaks to the strength of family, the power of optimistic realism, and the life lessons that have emerged from a diagnosis he never expected. Transcripts for this episode are available at: https://www.integrativetouch.org/conversations-on-healing  Show Notes: Read Jonanthan's book An Exercise in Uncertainty: A Memoir of Illness and Hope Check out Stand By Me here Learn more about CAR-T therapy Read The Anatomy of Hope This podcast was created by Integrative Touch (InTouch), which is changing healthcare through human connectivity. A leader in the field of integrative medicine, InTouch exists to alleviate pain and isolation for anyone affected by illness, disability or trauma. This includes kids and adults with cancers, genetic conditions, autism, cerebral palsy, traumatic stress, and other serious health issues. The founder, Shay Beider, pioneered a new therapy called Integrative Touch™Therapy that supports healing from trauma and serious illness. The organization provides proven integrative medicine therapies, education and support that fill critical healthcare gaps. Their success is driven by deep compassion, community and integrity.  Each year, InTouch reaches thousands of people at the Integrative Touch Healing Center, both in person and through Telehealth. Thanks to the incredible support of volunteers and contributors, InTouch created a unique scholarship model called Heal it Forward that brings services to people in need at little or no cost to them. To learn more or donate to Heal it Forward, please visit IntegrativeTouch.org  

In this week's episode, we'll learn about rapid, high-sensitivity diagnostic assays for TTP, or thrombotic thrombocytopenic purpura, that can reduce unnecessary treatments. After that: enhancing PD-1 blockade in relapsed/refractory extranodal NK/T-cell lymphoma. In a single-arm, phase 2 study, combined CD38 and PD-1 inhibition demonstrated durable responses and manageable safety. Finally, a lymphoma horror story with a happy ending. CREBBP mutations create a zombie enzyme that competes with its wild-type counterparts. By enforcing CD40 signaling, a bispecific antibody overcomes this effect and induces lymphoma cell death.Featured Articles:Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysisEfficacy of combined CD38 and PD-1 inhibition with isatuximab and cemiplimab for relapsed/refractory NK/T-cell lymphomaBlunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

Sarah and Nate break down a super strange, but very psychology-based CRO test, we chat about how bundles have completely changed Original Grain's whole business strategy, and contemplate the meaning of brand. All this and more, on this episode of Brain Driven Brands.   JOIN The TETHER Community- https://www.skool.com/tether-lab/about   CoHost: Nate Lagos Twitter: https://x.com/natelagos LinkedIn: https://www.linkedin.com/in/natelagos/ Tactical and Practical Podcast: https://podcasts.apple.com/us/podcast/tactical-practical/id1752915534   Learn more at: https://www.tetherinsights.io/ Twitter: https://x.com/SarahLevinger Linkedin: https://www.linkedin.com/in/sarahlevinger/  Instagram: https://www.instagram.com/sarah.levinger/ Watch me on YouTube: https://www.youtube.com/channel/UCKwfjt_7PU5N_2fTfHemXXg   Thanks to Cytrus for the theme song, “Sky High” You can follow and find them on Spotify:https://open.spotify.com/track/1oKGDsxjRdQlf2xHLZsiSJ?si=8fbd275dbbb54cbf  

In this conversation, Alessandro Bogliari chats with Pierre-Loïc Assayag, CEO and founder of Traackr, discussing the evolution of influencer marketing, the challenges of pricing transparency, and the importance of adapting strategies to local markets. They explore insights from a recent panel at SXSW, the impact of social media platform changes, and the future of influencer marketing in a rapidly evolving landscape.

This week, we're dropping in your feeds one day early to deliver our #DamnGood finds for Amazon Prime Day, which spans four full days this year, from July 8 - 11th! Join us as we curate, and review, some of the hottest trending products and stay tuned until the end to hear about the deepest discounts we could find at the end of the episode.

Treg-based cell therapies are nearing a clinical proof-of-concept inflection point, but in an environment that has dramatically shifted with the advent of CAR T therapies for autoimmune diseases. On the latest BioCentury This Week podcast, BioCentury's analysts discuss what these cell therapies need to show to be relevant in the fast-changing I&I world, and which types of indications may best suit the cells' unique profile.The team also explores the biotech sector's ongoing struggle to capture the interest of generalist investors, and what the next major theme might be to draw them back.The analysts then break down the key provisions in the recently passed U.S. reconciliation tax bill, highlighting the positive and negative developments, as well as the missed opportunities for the industry. This episode of BioCentury This Week was sponsored by IQVIA Biotech. View full story: https://www.biocentury.com/article/656376#biotech #biopharma #pharma #lifescience #CellTherapy #TregTherapy #CAR_T00:01 - Sponsor Message: IQVIA Biotech01:19 - Treg Inflection Point10:57 - Biotech's Next Big Story22:36 - Tax Bill ConsequencesTo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

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Neste Momento, a Catarina Martins fala-nos de como as relações afetivas passam também a ser relações patrimoniais quando nos casamos ou vivemos em união de facto. Regular de forma informada e intencional as relações patrimoniais é um passo crucial para vivermos casamentos mais conscientes.  A Catarina é Notária há 15 anos, num Cartório em Amarante. Realizada na sua profissão, a Catarina partilha connosco a sua experiência e conhecimento, na área dos casamentos e separações. Um lado muito pragmático, mas nem por isso menos apaixonante…Ouve, partilha e contribui para uma cultura de relações saudáveis, responsáveis e autênticas. Se não ouviste o episódio completo, podes fazê-lo, porque este foi mesmo só um momento…#140 Catarina Martins: Contratualizar o Amor? O episódio está disponível no Spotify, Apple Podcasts e nas outras plataformas de distribuição de Podcasts habituais. Também podes ver o vídeo do episódio no Spotify ou no nosso canal do Youtube. Para saberes mais sobre nós:. na página https://www.gp3sdivorcioconsciente.com/  . nas redes sociais @gp3s.divorcioconsciente; e. adquire o nosso livro nosso site https://www.gp3sdivorcioconsciente.com/livrodirectamente na editora ou em qualquer outra livraria física ou online

Well our bridge ambush was super successful, naturally, but it turns out the OT had a few more surprises in store for us. Most likely those surprises will not lead to Screech getting eaten to death but you never know. Time to step up our mimic murder mastery.The adventure continues with Screech Echo (Mike Bachmann), Selene Von Esper (Jennifer Cheek), R'Oarc (Nika Howard), T'Chuck (Tim Lanning), and our Dungeon Master Michael DiMauro. Don't forget to follow our editor David Stewart! Podcast art by https://www.instagram.com/tami_doodles/!Want the world to see your fan art?Post it with #DrunksAndDoodlesFind more info by clicking right here - https://linktr.ee/GAPCast Hosted on Acast. See acast.com/privacy for more information.

In this enlightening episode of Keeping Abreast, Dr. Jenn sits down with world-renowned surgical oncologist Dr. Francisco Contreras to explore how mindset, metabolic therapy, and integrative medicine can change the cancer care conversation.Guided by the influence of his father, a pioneer in holistic oncology, Dr. Contreras shares his path to becoming a surgeon and his mission to treat not just the disease, but the whole person. From patient empowerment to the limitations of conventional care, this episode offers a deep dive into the emotional, spiritual, and metabolic components of healing.You'll hear how innovative therapies at Oasis of Hope combine conventional medicine with holistic practices—and why patient education is the cornerstone of long-term success.This conversation is filled with hope, science, and practical insights to help you take charge of your healing journey.In This Episode, You Will Learn:How Dr. Contreras's father inspired his holistic cancer care approachWhy mindset and empowerment are critical in healingThe science behind metabolic therapy and low-glycemic nutritionWhat immunotherapy is—and how it's changing cancer outcomesHow alternative and conventional treatments can work togetherWhy movement, habit-building, and diet play vital roles in recoveryThe truth about high-dose vitamin C, off-label meds, and natural remediesHow innovative treatments like dendritic cell vaccines and CAR T cells workWhy patients deserve education, options, and hope

Audio roundup of selected biopharma industry content from Scrip over the business week ended July 4, 2025. In this episode: AbbVie's big autoimmune CAR-T play; In Vivo CAR-T interest grows; China deal perspectives from BIO; global pharma interest in Korea undeterred; and a look at the biggest drug sales disappointments. https://insights.citeline.com/scrip/podcasts/scrips-five-must-know-things/quick-listen-scrips-five-must-know-things-Y77FXMFAIFEVFK75G5QUSNSBOY/ This episode was produced with the help of AI text-to-voice and voice emulation tools. Playlist: soundcloud.com/citelinesounds/sets/scrips-five-must-know-things

CAR-T cells, a highly activated immune cell, have been used to treat a solid tumor, stomach cancer, for the first time. Yet the fact remains that CAR-Ts are expensive and time consuming to produce. Johns Hopkins Kimmel Cancer Center director … CAR-T cells are an expensive form of cancer treatment, but other techniques may soon supplant them, Elizabeth Tracey reports Read More »

You've probably heard of CAR-T cells, a type of immune cells taken from someone's body, grown up in a lab and trained to attack their cancer. CAR-Ts are known to be good for treating blood cancers like leukemia, and for … Will solid tumors now be treated with CAR-T cells? Elizabeth Tracey reports Read More »

For the first time CAR-T cells, a highly activated type of immune cell, have been used with some success to treat stomach cancer, a so-called solid tumor. William Nelson, director of the Kimmel Cancer Center at Johns Hopkins, says solid … Why has it been so hard to use CAR-T cells to treat solid tumors? Elizabeth Tracey reports Read More »

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW's Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In significant news this week, the FDA in the US has removed red tape that limits which centres could give CAR-T therapy, in a move to improve access to the therapies. The round-up this time focuses on other developments in cell and gene therapies (CGT) including two high profile acquisitions. You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Nesta aula de francês, vamos aprender o vocabulário essencial para lidar com duas instituições muito importantes no dia a dia: o banco e os Correios. Você vai saber como abrir uma conta, enviar ou retirar encomendas, e conversar com atendentes nesses contextos com mais segurança.1. No banco – vocabulário e frases úteisOuvrir un compte bancaire – Abrir uma conta bancária Un compte courant / un compte épargne – Conta corrente / poupança Une carte bancaire / CB / Carte bleu  / un relevé – Cartão bancário / extrato Déposer / retirer de l'argent – Depositar / sacar dinheiro Faire un virement – Fazer uma transferência Signer un document – Assinar um documentoExemplo: Bonjour, je voudrais ouvrir un compte courant, s'il vous plaît.Frases práticas:Quels sont les documents nécessaires ? – Quais documentos são necessários?Je voudrais retirer 100 euros. – Gostaria de sacar 100 euros.Je n'arrive pas à utiliser le distributeur. – Não consigo usar o caixa eletrônico.2. Problemas comuns no bancoMa carte ne fonctionne pas. – Meu cartão não está funcionando. J'ai perdu ma carte bancaire. – Perdi meu cartão bancário. Je voudrais bloquer / vérrouiller mon compte. – Quero bloquear minha conta. Je n'ai pas reçu mon relevé. – Não recebi meu extrato. Est-ce que je peux prendre un rendez-vous avec un conseiller ? – Posso marcar uma reunião com um gerente?*****Curso completo disponível na Udemy (para melhorar a gramática em francês (compreensão oral + compreensão escrita) : Clique aqui (https://www.udemy.com/course/curso-de-frances-bruna-lewis/?referralCode=4A46AFBE0D4A61D8A3D1)*****3. Nos Correios – vocabulário e situações frequentesEnvoyer / recevoir un colis – Enviar / receber um pacote Un timbre / une enveloppe / un recommandé – Um selo / envelope / correspondência registrada Un avis de passage – Aviso de tentativa de entrega Un colis suivi – Pacote com rastreamento Une pièce d'identité – Documento de identidadeExemplo: Bonjour, je viens récupérer un colis. Voici mon avis de passage.Frases práticas:Combien coûte l'envoi de cette lettre pour le Brésil ? – Quanto custa enviar esta carta para o Brasil?Est-ce que je peux acheter des timbres ici ? – Posso comprar selos aqui?J'ai reçu un message disant que mon colis est arrivé. – Recebi uma mensagem dizendo que meu pacote chegou.4. Expressões para interagir com atendentesJe ne parle pas très bien français, mais je vais essayer. – Não falo muito bem francês, mas vou tentar.Pouvez-vous répéter, s'il vous plaît ? – Pode repetir, por favor?C'est urgent. – É urgente.Merci beaucoup pour votre aide. – Muito obrigado(a) pela ajuda.Ir ao banco ou aos Correios em outro país pode parecer difícil, mas com essas frases e esse vocabulário, você já estará bem preparado(a). Bonne chance avec tes démarches !

6:00am – 7:00am: Few Things You Should Know, Name Your Car, Vegas Sports 7:00am – 8:00am: Joey Chestnut, What’s In Your Online Cart 8:00am – 9:00am: Few More Things You Should Know, Black Sabbath 9:00am – 10:am: Other News, Feel Good/Close

AiArthritis is bringing you along for the journey as part of our Go With Us! Program, this time straight from the EULAR 2025 in Barcelona. In this episode, we're spotlighting key research updates that matter most to patients living with AiArthritis diseases. Our 'co hosts, Leila, Tiffany, Deb, and Eileen, are on the ground at EULAR, reporting back with fresh insights into patient-prioritized topics. You'll hear how nutrition and microbiome research is shifting how we understand inflammation and autoimmune risk, why CAR T-cell therapy is creating buzz as a potential path to long-term remission, and what new research is saying about enthesitis in spondyloarthritis. Plus, learn more about the debate on the pros and cons of cannabis use for chronic pain management. This episode brings the conference experience straight to you with a focus on what it all means for real patients.   Donate to Support the Show: www.aiarthritis.org/donate   Episode Highlights: Insights from new research linking diet and gut health to autoimmune activity What CAR T-cell therapy could mean for the future of treatment A deeper look at enthesitis and how it's being understood in spondyloarthritis How the medical community is reevaluating the use of cannabis in treatment plans.   Links & Resources Go With Us! To EULAR 2025 YouTube Playlist: https://www.youtube.com/playlist?list=PLZW5ZyvNnYl3wsrI7usV495JH2OMfUdzN Have questions about this episode or topics you want to hear us bring to the table? Email us at podcast@aiarthritis.org  Follow AiArthritis on all social media platforms @IFAiArthritis Sign up for our Monthly AiArthritis Voices 360 Talk Show newsletter! HERE   Connect with our Co Hosts:   Leila is the Health Education Manager at the International Foundation for AiArthritis. She is a person living with Lupus and Sjögren's disease. She is passionate about inclusion and diversity in health education and meeting individuals where they are at in order to learn in a way that resonates with them.   Eileen Davidson is a rheumatoid arthritis patient advocate from Vancouver Canada. She volunteers with the Arthritis Research Canada patient advisory board and the Canadian Institute of Health Research - Institute of Musculoskeletal Health and Arthritis patient engagement research ambassador, among others. When not advocating she is writing about her experience with arthritis through Creaky Joints, Healthline, Chronic Eileen or can be found being a mom to her son Jacob.   Tiffany Westrich-Robertson is the CEO at AiArthritis (International Foundation for Autoimmune & Autoinflammatory Arthritis) and uses her professional expertise in mind-mapping and problem solving to help others, like her, who live with AiArthritis diseases work in unison to identify and solve unresolved community issues.   Deb Constien is a medically retired Registered Dietitian and a Representative for AiArthritis with Rheumatoid Arthritis. Deb is also on the Advisory Council for WREN- Wisconsin Research Education Network and a Patient Family Advisor- PFA on an International PCORI research study for ACP- Advanced Care Planning.

Join us in this episode as Jeff Auletta, MD, delves into the cutting-edge science behind stem cell transplants and cellular therapies, including breakthroughs in chimeric antigen receptor (CAR) T-cell therapy, hematopoietic cell transplantation (HCT), and beyond… Dr. Auletta is the senior vice president of health equity at the National Marrow Donor Program (NMDP) and chief scientific officer of the Center for International Blood and Marrow Transplant Research (CIBMTR). At both facilities, he collaborates with academic centers and industry partners to advance the field of cellular therapy – ensuring equal access to cellular therapies and transforming the post-transplant outcome landscape by improving patient survival and quality of life. Click play to explore: The intricacies and benefits of blood stem cell transplantation. The most common types of blood-based diseases. The role of bone marrow in the functioning of the circulatory system.  The three sources of hematopoietic stem cells (HSCs). Whether you're curious about what a transplant is, the associated risks, or how to find a donor, this conversation is sure to provide interesting insights into the cutting-edge world of stem cell research. Join in now to learn more! Be sure to follow along with Dr. Auletta and his ongoing work by following him on X @JeffAuletta. Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Wristband that provides relief for upper limb tremor is approved; FDA warns of clinically significant weight loss in younger kids taking ADHD meds; REMS removed for CAR T-cell immunotherapies; treatment approved for lung cancer patients with EGFR exon20 insertion mutations; and CDC committee recommends removing preservative from flu vaccines.

Concluye emergencia por lluvias: Sheinbaum Interceptan 32 cargamentos de ganado con gusano barrenadorAmenazas de bomba paralizan aeropuertos en CanadáMás información en nuestro podcast

In this week's episode we'll learn more about a novel mouse model that recapitulates many of the properties of human sickle cell SC disease; results from the induction phase of the risk-adapted MIDAS trial of isatuximab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed, transplant-eligible multiple myeloma; and a link between splicing factor mutations and competitive fitness in myelodysplastic syndrome stem cells.Featured articles:A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyureaIsatuximab, carfilzomib, lenalidomide, and dexamethasone induction in newly diagnosed myeloma: analysis of the MIDAS trialCell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells

We revisit the very first episode of Add to Cart, when Kulap shares her newest book purchase, her recent Christmas splurge (dogs are involved), and why she’s giving up on her home modeling career. Meanwhile, SuChin is investigating how to improve her hand strength and reveals the one beauty product she actually believes isn’t a scam. The two delve into why creature comforts feel so important right now and how to best address the Amazon in the room. For product links and good times, follow @addtocartpod on Instagram. Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia. See omnystudio.com/listener for privacy information.

The Trump administration's overhaul of FDA is still underway, but the agency has already veered away from its decades-long trajectory in ways that will profoundly reshape medical product development and the lives of U.S. patients. On the latest BioCentury This Week podcast, BioCentury's analysts assess who the winners and losers are likely to be as FDA changes shape.The analysts discuss a pair of in vivo CAR T companies: Esobiotec, whose story offers a case study in product-focused strategy, and Capstan Therapeutics, whose in vivo CAR T platform for immunological disorders attracted a buyer in Abbvie. The team also analyzes why data from Compass Pathways for psilocybin therapy COMP360 disappointed investors despite hitting the endpoint, and how molecular glues could be the future of selective CDK2 targeting. This episode of BioCentury This Week was sponsored by ICON Biotech.View full story: https://www.biocentury.com/article/656341#biotech #biopharma #pharma #lifescience #RandD #drugapproval00:01 - Sponsor Message: ICON Biotech02:26 - BioCentury Grand Rounds Europe05:02 - FDA's Future15:03 - Psychedelics22:53 - Esobiotech's Fast Exit31:37 - Molecular Glues and CDK234:43 - Abbvie's Capstan BuyTo submit a question to BioCentury's editors, email the BioCentury This Week team at podcasts@biocentury.com.Reach us by sending a text

In this episode of The Common Sense MD, Dr. Tom Rogers welcomes back oncologist Dr. Jamal Maatouk for a compelling exploration of cancer care that goes well beyond the basics. Building on their previous holistic discussion of the cancer experience, Dr. Rogers and Dr. Maatouk dive deeper into how cancer treatment decisions are made—from surgery, chemotherapy, and radiation to cutting-edge targeted therapies and immunotherapies like CAR T.Dr. Maatouk shares her philosophy that there is no one-size-fits-all approach in oncology. She highlights the importance of truly getting to know each patient as a whole person, considering their wishes, unique biology, and even their spiritual outlook. The conversation unpacks the difference between immunotherapy and targeted therapy in an easy-to-understand way, as well as when and why oncologists might recommend gentler approaches like dose reductions or integrative support for quality of life.The doctors have an open, honest conversation about the value of second opinions, the evolving science of cancer, and the growing trend of patients taking an active role in their care—including the use of supplements and alternative therapies. Dr. Maatouk powerfully expresses her belief in the innate ability of the human body to heal, the role of hope and love in medicine, and her commitment to supporting each patient on their own unique healing journey.If you or a loved one are navigating cancer—or simply want a refreshing, compassionate take on modern medicine—this episode is an inspiring reminder that healing is possible, and that true care starts with listening, empathy, and hope.What did you think of this episode of the podcast? Let us know by leaving a review!Connect with Performance Medicine!Check out our new online vitamin store:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://performancemedicine.net/shop/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sign up for our weekly newsletter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://performancemedicine.net/doctors-note-sign-up/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@PMedicine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@PerformancemedicineTN⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Performance Medicine

These lectures will explore two Arthurian romances, Chretien de Troyes' Knight of the Cart, and the Cistercian text we know as The Quest of the Holy Grail, through the lens of Catholic teaching on redemption, divine grace, and the pursuit of virtue.

Kristin Charbo is the Co-Founder and CEO of Glonuts, the better-for-you donut brand redefining indulgence with clean ingredients and low sugar. But her journey didn't start in food or even in business. Kristin spent over 15 years in luxury hospitality, opening hotels for brands like Mandarin Oriental and PUBLIC in New York. It wasn't until a PCOS diagnosis in her early 20s that she was forced to rethink her relationship with food, wellness, and ultimately, her career. That health wake-up call eventually sparked the idea for a nostalgic, blood-sugar-friendly treat she wished existed. What started as a “healthy donut thing” from a coffee cart quickly took on a life of its own, leading Kristin and her partner Grover to deliver over 100,000 donuts from their one-bedroom apartment and even use their wedding money to rebrand the business. Today, Glonuts is one of the most exciting brands in wellness snacking, stocked everywhere from Erewhon to H-E-B markets and other retailers all across the US.In this episode, Kristin gets real about what it actually takes to build something from nothing—when you don't have a blueprint, just a product people love and the grit to figure it out. She opens up about the mental rollercoaster of entrepreneurship, the scrappy early days of hand-delivering donuts, and the power of iterating on feedback. We talk about the challenges of fundraising as a female founder, how she built a network of powerhouse women who now double as investors and advisors, and why personal growth is just as critical as business growth. Whether you're dreaming of starting your own thing or in the thick of figuring it out as you go, Kristin's story is your reminder that success isn't always linear but it always starts with taking the first messy step.In this episode, we'll talk to Kristin about:* Glonuts began as an unexpected leap into entrepreneurship. [03:07]* The early days of building Glonuts + getting feedback. [04:55]* When Kristin first felt the entrepreneurial itch. [11:34]* Kristin's upbringing and relationship with food. [15:14]* Getting fired from corporate + going all in on Glonuts. [18:15]* Starting Glonuts from their home kitchen. [20:13]* How they got into Erewhon. [21:35]* Navigating the tough moments as a founder. [26:27]* Debunking the myth of overnight success. [33:08]* The unique challenges women face in fundraising. [34:38]* Investing in branding can significantly impact business success. [41:48]* Finding the right co-packer and the exact steps she took. [45:50]* Personal growth is a significant part of the entrepreneurial journey. [54:16]* The power of journaling for reflection and gratitude. [56:14]This episode is brought to you by beeya: * Learn more about beeya's seed cycling bundle at https://beeyawellness.com/free to find out how to tackle hormonal imbalances. * Get $10 off your order by using promo code BEHINDHEREMPIRE10Follow Yasmin: * Instagram: https://www.instagram.com/yasminknouri/* Stay updated & subscribe to our newsletter: https://www.behindherempire.com/Follow Kristin: * Instagram: https://www.instagram.com/kristinfromglonuts/* Instagram: https://www.instagram.com/eatglonuts/* Website: https://eatglonuts.com/ Hosted on Acast. See acast.com/privacy for more information.

Episode 255Special Guest:Paul Jackmanhttps://www.jackmanworks.com/https://www.youtube.com/jackmanworkshttps://www.instagram.com/jackman_worksMusic Video:https://www.youtube.com/watch?v=pGCJ7O0NlOEGet Adirondack Chair templates and plans:danirondackchair.comUse code Dunlap for 20% offSponsor:Onefinity CNC:The industry standard for at home production CNCs. Ball screw and linear rail construction - No beltsCompatible with all popular software, 15 minute setup, infinitely upgradable, and world class tech support!And its made in Canada. Which means Maple Glazed Rails!One Machine - Infinite possibilitiesUse code ‘AWP' at checkout or use the link below to order:https://www.onefinitycnc.com/?ref=AWP Airweights:AirWeights turns any CNC table into a powerful and modular vacuum workholding table, and will unleash new levels of capability and efficiency from your machine.It might not seem like it, but air is heavy! The pressure of the atmosphere above us pushes down with a force of almost 15lbs per square inch.Use code ‘AWP' at checkout!https://airweights.com/ Sign up for Patreon for Early access, and special Patreon-only content:https://www.patreon.com/anotherwoodshoppodcastPATREON GIVEAWAY!Donate to Maker's For St. JudeEvery $5 earns you an extra entry in the Patreon Giveaway (Paid Patrons Only)http://fundraising.stjude.org/goto/anotherwoodshoppodcast Whats on our bench:

What is in the This Week in Science Podcast? This Week:  Vera's First Look, Dragons, Fertility. Anthrobots, Vascular Organoids, Orcas, Octopi, Car T, Type 1 Cure, Ears, Glow Brains, Morning Chorus, and Much More Science! Become a Patron! Check out the full unedited episode of our podcast on YouTube or Twitch. Remember that you can […] The post 25 June, 2025 – Episode 1020 – The Future of Science Starts Now appeared first on This Week in Science - The Kickass Science Podcast.

Broadcast from KSQD, Santa Cruz on 6-26-2025: Dr. Dawn opens with groundbreaking results from Vertex Pharmaceuticals' stem cell treatment for severe type 1 diabetes. The experimental therapy, Zimislecel, converts stem cells into pancreatic islet cells and infuses them into patients. In a 12-person study, 10 patients no longer need insulin after one year. The cells migrated to the liver and began producing insulin in response to glucose levels. Patients with hypoglycemic unawareness saw complete elimination of dangerous episodes after three months. However, patients must take lifelong immunosuppressive drugs to prevent rejection. The research represents 25 years of work by Harvard's Doug Melton. A caller asks about Keytruda treatment for melanoma. Dr. Dawn explains it's an immunotherapy drug targeting programmed death receptors that cancer cells hijack to evade immune response. The drug can cause serious immune overreactions but is standard for metastatic melanoma. Treatment protocols depend on cancer staging. For young patients with decades to lose, aggressive treatment is often justified despite risks. An email about morning arthritis pain leads to chronotherapy research discussion. Macrophages have energy levels that peak in the morning when inflammasome activation is quicker and more robust, explaining why arthritis pain is worst after overnight rest. Treatment timing could optimize anti-inflammatory medications by taking them at bedtime. Another email about eye irritation prompts diagnostic discussion. Dr. Dawn recommends examining for bacterial blepharitis before assuming food allergies and testing antihistamine drops. For elimination diets, common allergens include wheat, dairy, corn, soy, and peanuts. However, without other symptoms, food allergies are unlikely causes of isolated eye problems. Dr. Dawn explores advancing CAR-T cell therapy using RNA technology. Traditional therapy costs up to $500,000 per patient requiring lab reprogramming. New RNA-containing nanoparticles temporarily create antigen receptors for about one week. Mouse studies eliminated detectable tumors at highest doses. While effects are temporary, this could dramatically reduce costs and complexity. She discusses DNA forensics evolution from O.J. trial era to current technologies. New paleogenomics technology can analyze fragmented DNA from hair, previously considered unusable. Mitochondrial DNA analysis can definitively exonerate suspects. This led to Charles Fane's release after 17 years on death row when hair evidence proved innocence and identified the actual perpetrator. Dr. Dawn introduces Barrett's esophagus screening replacing invasive endoscopy. Patients swallow a capsule containing a compressed sponge that expands in the stomach and is pulled out via string, collecting esophageal cells. The test identifies abnormalities with 100-fold increased cancer risk when positive and 98% accuracy when negative, allowing targeted endoscopy only for high-risk patients. She concludes discussing body composition analysis superiority over BMI. Studies found overweight BMI showed 3.6 times higher heart disease risk, while large waist circumference showed four times higher risk. However, BMI had no significant relationship with overall mortality. Dr. Dawn advocates for bioimpedance analysis devices to measure body fat percentage and track muscle loss.

Broadcast from KSQD, Santa Cruz on 6-26-2025: Dr. Dawn opens with groundbreaking results from Vertex Pharmaceuticals' stem cell treatment for severe type 1 diabetes. The experimental therapy, Zimislecel, converts stem cells into pancreatic islet cells and infuses them into patients. In a 12-person study, 10 patients no longer need insulin after one year. The cells migrated to the liver and began producing insulin in response to glucose levels. Patients with hypoglycemic unawareness saw complete elimination of dangerous episodes after three months. However, patients must take lifelong immunosuppressive drugs to prevent rejection. The research represents 25 years of work by Harvard's Doug Melton. A caller asks about Keytruda treatment for melanoma. Dr. Dawn explains it's an immunotherapy drug targeting programmed death receptors that cancer cells hijack to evade immune response. The drug can cause serious immune overreactions but is standard for metastatic melanoma. Treatment protocols depend on cancer staging. For young patients with decades to lose, aggressive treatment is often justified despite risks. An email about morning arthritis pain leads to chronotherapy research discussion. Macrophages have energy levels that peak in the morning when inflammasome activation is quicker and more robust, explaining why arthritis pain is worst after overnight rest. Treatment timing could optimize anti-inflammatory medications by taking them at bedtime. Another email about eye irritation prompts diagnostic discussion. Dr. Dawn recommends examining for bacterial blepharitis before assuming food allergies and testing antihistamine drops. For elimination diets, common allergens include wheat, dairy, corn, soy, and peanuts. However, without other symptoms, food allergies are unlikely causes of isolated eye problems. Dr. Dawn explores advancing CAR-T cell therapy using RNA technology. Traditional therapy costs up to $500,000 per patient requiring lab reprogramming. New RNA-containing nanoparticles temporarily create antigen receptors for about one week. Mouse studies eliminated detectable tumors at highest doses. While effects are temporary, this could dramatically reduce costs and complexity. She discusses DNA forensics evolution from O.J. trial era to current technologies. New paleogenomics technology can analyze fragmented DNA from hair, previously considered unusable. Mitochondrial DNA analysis can definitively exonerate suspects. This led to Charles Fane's release after 17 years on death row when hair evidence proved innocence and identified the actual perpetrator. Dr. Dawn introduces Barrett's esophagus screening replacing invasive endoscopy. Patients swallow a capsule containing a compressed sponge that expands in the stomach and is pulled out via string, collecting esophageal cells. The test identifies abnormalities with 100-fold increased cancer risk when positive and 98% accuracy when negative, allowing targeted endoscopy only for high-risk patients. She concludes discussing body composition analysis superiority over BMI. Studies found overweight BMI showed 3.6 times higher heart disease risk, while large waist circumference showed four times higher risk. However, BMI had no significant relationship with overall mortality. Dr. Dawn advocates for bioimpedance analysis devices to measure body fat percentage and track muscle loss.

This week, the gals invite Irish icon Katie Charlwood of Who Did What Now Podcast to chat about the dangers of piracy (and also toddlers), some sticky handrails, a horrible hookup, brownie temptation, a coffin catastrophe, and a long-winded obit from one very lucky man. Tune in for June's Gossip at the Corpse Cart! For a full list of show sponsors, visit https://wineandcrimepodcast.com/sponsors. To advertise on Wine & Crime, please email ad-sales@libsyn.com or go to advertising.libsyn.com/winecrime.