Podcasts about gpus

BrainChip CEO Sean Hehir joins me to unpack where artificial intelligence is actually headed—and why the dominant “everything in the data center” narrative is incomplete.Most AI conversations fixate on massive models, GPU farms, and trillion-dollar infrastructure bets. This episode shifts the frame. Sean and I explore the structural reality that power consumption, latency, and grid constraints are forcing AI to decentralize—and what that means for founders, engineers, and the broader economy.Sean explains how neuromorphic computing and ultra-low-power silicon enable AI inference outside the data center—inside wearables, medical devices, drones, manufacturing systems, and even space applications. We examine why CPUs and GPUs aren't optimized for edge workloads, how custom silicon changes the economics, and why power efficiency isn't a side issue—it's the bottleneck that determines what scales.The conversation expands into workforce displacement, labor fluidity, productivity cycles, and whether technological acceleration inevitably creates unemployment crises—or simply reshuffles value creation again, as history repeatedly shows.This isn't a speculative futurism episode. It's a grounded look at model trends, infrastructure limits, and how companies survive inside a market moving at month-scale rather than decade-scale.The lesson isn't that AI replaces everything.It's that architecture determines outcomes.TL;DR* AI is centralizing in data centers—but it's also rapidly decentralizing to the edge* Power constraints will shape the next phase of AI more than hype cycles* Neuromorphic and event-driven silicon drastically reduce energy per compute* Edge AI enables medical wearables, safety detection, space systems, and industrial automation* Models are getting larger—but optimization techniques will shrink them into smaller form factors* Productivity gains historically displace tasks—not human adaptability* The future isn't about bigger servers—it's about smarter distribution* Lowest power per compute is a strategic advantage, not a marketing lineMemorable Lines* “Don't bet against humanity. We're very creative.”* “The future of AI isn't just in data centers.”* “Power isn't a feature—it's the constraint.”* “If you're the lowest power solution, you will always have customers.”* “Architecture decides what becomes possible.”GuestSean Hehir — CEO of BrainChipTechnology executive leading the commercialization of neuromorphic AI processors focused on ultra-low-power edge inference. Oversees BrainChip's evolution from early engineering innovation to market-driven, customer-focused deployment.

U.S. markets rebounded sharply as fears of AI-driven disruption eased, lifting the S&P 500, Nasdaq, and Dow in a broad relief rally. A blockbuster multiyear partnership between Advanced Micro Devices and Meta Platforms — including up to 6 gigawatts of GPUs and a potential 160 million-share warrant — reignited the AI capex narrative and raised fresh questions about competition with Nvidia. Meanwhile, software names like Salesforce, ServiceNow, and DocuSign bounced as investors reconsider whether AI is a threat or a tailwind. Ryan Detrick, Chief Market Strategist, Carson Group breaks down whether this is just a relief rally, what it means for the AI arms race, and how global tariffs and industrial names like John Deere fit into the bigger macro picture. Produced/Presented: Ryan Huang Image: Geralt via PixabaySee omnystudio.com/listener for privacy information.

Cory Johnson takes a broader look at AMD Inc.'s (AMD) new deal with Meta Platforms (META) that will provide the social media giant with 6 gigawatts of GPUs. He sees the deal as one where Meta is diversifying its AI buildout, seen in its Nvidia (NVDA) expanded partnership last week. Cory explains how it highlights "two worlds" often intertwined in the AI race. ======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

In this week's episode, we take a look at hysteria over AI, and compare it to past religious movements like William Miller's Great Disappointment. This coupon code will get you 50% off the audiobook of Half-Elven Thief, Book #1 in the Half-Elven Thief series, (as excellently narrated by Leanne Woodward) at my Payhip store: RIVAH50 The coupon code is valid through March 2, 2026. So if you need a new audiobook this winter, we've got you covered! TRANSCRIPT 00:00:00 Introduction and Writing Updates Hello, everyone. Welcome to Episode 291 of The Pulp Writer Show. My name is Jonathan Moeller. Today is February 28th, 2026, and today we're looking at AI hysteria and whether or not AI gives any actual benefits to people. We also have Coupon of the Week, progress updates on my current writing projects, and also Question the Week, where we talk to people about AI. But first, let's start off with Coupon of the Week. This week's coupon code will get you 50% off the audiobook of Half-Elven Thief (as excellently narrated by Leanne Woodward) at my Payhip store. That coupon code is RIVAH50. This coupon code will be valid through March 2, 2026. So if you need a new audiobook as we exit winter and come into spring, we have got you covered. Now let's have an update on my current writing and publishing and audiobook projects. I'm pleased to report that the rough draft of Cloak of Summoning is done. It turned out to be just about as long as Cloak of Worlds, maybe a thousand words shorter. I am about 20% through the first round of editing, and I am hopeful that that book will be out sometime in March, probably the first week of March if all go as well. I've also written a short story called Dragon Claw that newsletter subscribers will get for free in ebook format when Cloak of Summoning comes out, which as I said will hopefully be in early March. I'm also 11,000 words into Blade of Wraiths, the fourth book in my Blades of Ruin epic fantasy series, and that will be my main project once Cloak of Summoning is published. In audiobook news, the audiobook of Blade of Shadows (as narrated by Brad Wills) is now out at almost all the stores, so you can get it at Audible, Apple, Google Play, Kobo, and the other main stores. Cloak of Titans (as narrated by Hollis McCarthy) is done and is currently rolling out to the stores. I think as of right now, you can get it at Google Play, Kobo, and my own Payhip store, but it should be showing up on Audible and the other main stores before too much longer. So that is where I'm at with my current writing, publishing, and audiobook projects. 00:01:56 Question of the Week Now let's move on to Question of the Week. For the first Question of the Week of 2026 and this week's question: have you personally derived any benefits or experienced any negatives from the rise of generative AI? And this question was inspired by the topic of this week's post, obviously enough since we're talking about AI. I should note that this is a contentious topic with divergent opinions, and so I asked people to remain civil in the comments and they definitely were, so thank you for everyone for that. Now let's have some opinions on AI before I tell you how AI has positively and mostly negatively affected my life. Joachim says: I have not used AI for private purposes. My Con: My Chromebook might be obsolete rather sooner than later. In my company, we use an AI, which is helpful. It has all the knowledge articles, so you can ask, how do I do this or that? The company's Con: laptop prices are going up. Eddie says: My Cons are much the same as yours. My Pros are using it to create images for tabletop games to help players visualize monsters and NPCs. I have found it effective in turning voice to text meeting notes into meeting minutes and actions. Jesse says: Software engineer here. I have found it helpful when I'm working on something in a language I'm not as familiar with the syntax. As a "how I might do this" learning tool, it's not bad. As a "do this for me/vibe code" thing, no thanks…too much trust. John says: Yes and no. I was in an AI startup that stopped paying me and my team for two months then let us go. We're currently suing them for back pay, but the tech worked and is still working. I also work in ad tech. Devs are trying to get more productive using AI tools. It's hit and miss as far as I can tell, but using traditional machine learning and data science to optimize marketing has worked for decades and still works, but that's not what people consider to be AI nowadays. Also drove across the country last August and used ChatGPT to plan my trip, and that works splendidly. I think John might win here for largest negative in his comment though, to be fair, that's more for business reasons than for AI itself, though I, for his sake, I'm pleased he was able to use ChatGPT to plan his drive across the country and ChatGPT didn't send him driving off a cliff someplace. Jenny says: I'm so over everyone trying to push this "solution" on me. It's like protein enhanced foods. Stop trying to put protein and AI into everything. Just put it where it makes sense or let me choose it. My negative experiences far outweigh anything helpful. Jimmy says: I have quit using Google search. It never tried to find the answer that I asked for. It just returned what it felt like. Its answers usually matched the paid ads it led the list with. Rob says: Okay for meeting notes and rough drafting for job applications, et cetera. Other than that, seems to have limited use for me personally and is a nuisance on my phone, internet browser, et cetera. And finally, Randy says: my biggest Con is that the AI answers that pop up when I'm trying to search range between inaccurate and dangerously wrong. I suspect many people don't realize they aren't reading actual data when they see them. So thank you to everyone who shared their thoughts on that. For myself, I've mostly experienced negative things with AI and a few positive things though to be honest, both the positive and negative things were relatively minor in the greater scheme of things. So I shall list off the Pros and Cons of my experiences with generative AI. I should mention that none of my books, short stories, for sale audiobooks, or book covers contain any AI elements. If it says Jonathan Moeller on the cover and it's not on YouTube, then it is 100% human made. Now, the Pros and Cons. The Pros: Power Director 365, the video editing program I use for YouTube, has an "animated by AI" feature so I've used it to animate some of my book covers for use of Facebook ads with middling results at best. I used Google's Voice AI stuff to create AI voice versions of the Silent Order books and then put them on YouTube because I wanted to understand the technology. I'm not planning to ever do actual audiobook versions of Silent Order since they wouldn't make back any money, so I wasn't screwing a narrator out of work and the voices involved were licensed by Google, so there was no copyright infringement the way there is with companies like Anthropic. That said, I suspect this is less generative AI and simply a more advanced text to speech technology, which has been around forever. I mean, you could do text to speech back on the earliest versions of the Macintosh. I mean, ideally, I would like text to speech to just be a button in your ereader app of choice for accessibility reasons, and then you can purchase the audiobook if the text to speech was too bland. Overall, a lot of people listen to the AI versions on YouTube, but the listeners mostly complained about the synthetic voice and would've preferred a real narrator, unsurprisingly. Now onto the Cons. Facebook ads went from very effective to middling at best on a good day, thanks to their Advantage Plus AI. I am constantly bombarded by AI generated scam emails of several different varieties. I deleted twelve before I recorded this. The price of Microsoft Office went up, the price for RAM and GPUs went up due to data center hoarding them all. The price for electricity has gone up. Windows 11 and Microsoft Office's performance has gone down quite a bit due to forced AI integration. In fact, I got so annoyed at Windows 11, I switched to writing on a Mac Mini, which I suppose was a positive because I like the Mac Mini, but still. Google Search and all Google products in general are much less useful because of AI and the quality of information on the internet (already low) has gone down quite a bit due to the prevalence of AI slop. Admittedly, neither these Pros or Cons are majorly serious to me personally (with the possible exception of electricity prices going up), but the Cons definitely outweigh the Pros. I can confidently say I have derived no real benefit from generative AI, and I suspect a lot of other people could say the same, if they're honest. 00:07:27 Main Topic of the Week: William Miller, The Great Disappointment, and AI Now onto our related main topic this week, AI hysteria, William Miller, and The Great Disappointment. This past week there were numerous articles from and interviews with various AI bros saying that within 12 to 18 months, AI will replace white collar work and humanity must simply adjust. When I read these articles, I wasn't reminded of the Singularity, of AI, of Skynet and the Terminator, or anything technological. Instead, I thought of a preacher named William Miller who died about 190 years ago. William Miller came out of the Second Great Awakening, which was one of the waves of religious vitality and furor that grip America every so often. Miller almost died in combat as an officer in the War of 1812, and saw one of his men killed in front of him, which understandably left a lasting impression. His experiences led him to an examination of mortality that resulted in a fervent Baptist conversion. He also became convinced that he could calculate the date of Christ's return from the Bible and decided that Jesus Christ would return on October 22nd, 1844. By then, he had a substantial following, and on the day his followers gathered in their churches to await the End of Days and the judging of the living and the dead, many of them having already given away their possessions, but nothing happened. Miller's movement collapsed and most of his followers abandoned their beliefs, though some splinter groups eventually involved into the Adventist branch of American Protestantism, of which the Seventh Day Adventists are the most prominent. Nowadays, when Miller is discussed online, the usual tone is to laugh at the religious rubes from the benighted past, so unlike us enlightened and savvy moderns. But I think the truth is that Miller succumbed to a universal human impulse. Every generation thinks that it is going to be the last generation or the generation that will see the culmination of history, whether they're viewing that through a religious lens or a secular lens. For example, when I was in my early twenties, I knew a very religious woman my own age, who was convinced that the world had become so wicked that it would end by the time she was 30. A few years later, I met another woman who thought global warming would ensure the collapse of the ecosystem and the end of the food chain by the time we were 30. However, I have not been 30 for a rather long span of time now, and for better or for worse, the world grinds on. Nor is this an impulse limited to my own generation. People who came of age during the Cold War thought the world would end in nuclear fire during their lifetimes and a little after that from global cooling. Lesser examples could be seen in the Y2K scare in 2000. Throughout the Middle Ages and the early modern period, it was common for peasant revolts to be led by charismatic preachers who predicted that soon all thrones would be overthrown and Christ would return to judge the living and the dead. Because of all these examples, I'm certain there is a universal human impulse to believe that the world will end in our lifetimes. I think this comes partly from a combination of fear and hope, fear of the future and the end of the world and hope that one's life will be lifted out of the mundane in the final fulfillment of history. You don't have to get up and go to school or work tomorrow if the world ends, but the truth is that the world is most likely not going to end, and you and I are probably going to have to get up and go to work tomorrow. I think the hyperbole about AI comes from that same sort of apocalyptic impulse, this idea that one is living to see and participating in the apotheosis of history when what one is in fact doing is using a money losing chatbot that frequently gets things wrong. To be clear, AI isn't going to wipe out white collar work, and it isn't going to cause the collapse of society, though like cryptocurrency, it will cause a lot of harm without very much benefit. AI simply isn't good enough and doesn't do what does boosters say that it can do. There are numerous people who, in my opinion, are accurately explaining and pointing out the many flaws in AI and in the economic bubble it has created, just as there were people who predicted the fall of the Soviet Union, the dot-com bubble, the housing bubble, the criminal activities of FTX and the flaws of cryptocurrency, and were frequently derided as cranks until subsequent events prove them right. So why all the hyperbole around AI? I think part of it is the end of days impulse we discussed above. The rest of it, I'm afraid, is simple crass desire for money and power. Why are all these tech companies burning unfathomable sums of money on AI when it's obvious, painfully obvious, that the bubble is heading for a crash? After the dot-com crash of the early 2000s, the Internet companies that survived eventually evolved into the tech titans of our day (Amazon and Google come to mind). All these different AI companies and boosters are hoping that their company is the one that survives and becomes the next titan conglomerate of the 2030s. Admittedly, I think this is unlikely. I think that while the most probable outcome for the current model of AI, LLMs, and generative AI is that it ends up like cryptocurrency. For a while, crypto advocates thought that it would overthrow central banking and lead to unprecedented freedom and prosperity. However, while there are many valid criticisms to be made of central banking and fiat currency, one of their advantages is that that they do a good job of shutting down the kind of scams that crypto easily facilitates. For all the glowing promises of its boosters, the primary use case for cryptocurrency has been to cause economic disruptions and to facilitate crimes and scams. I suspect AI will probably degenerate down to a similar state once the bubble pops. The technology won't go away, but it can't do all the miraculous things its backers promise. The money is going to run out eventually and it will inflict a lot of economic damage on its way out. And like crypto, AI will mostly have negative uses. Likely its most common use cases will be to help students cheat on exams, make stupid political memes where someone's least favorite politician (whoever that is) is shaking hands with Emperor Palpatine or Thanos or whoever, engage in mass copyright infringement, and to scam seniors out of their savings. So if you are disturbed by the rhetoric around AI, take heart. When you read an article from someone announcing the glories of AI and discussing how all of civilization will have to rework itself around AI, remember that the person in question is most likely seeking money or power, or are like William Miller's followers the day before October 22nd, 1844. So that is it for this week. Thank you for listening to The Pulp Writer Show. I hope you found the show useful. A reminder that you can listen to all the back episodes at https://thepulpwritershow.com. If you enjoyed the podcast, please leave a review on your podcasting platform of choice. Stay safe and stay healthy, and we'll see you all next week.  

In this episode, the crew dives into reports that Palo Alto Networks allegedly avoided directly attributing a threat campaign to China over fears of retaliation—sparking a broader debate about corporate and government threat attribution, geopolitics, and whether attribution still matters in today's cyber landscape.They also explore the escalating AI arms race, including Meta's aggressive (and expensive) talent poaching, the growing rivalry between OpenAI and Anthropic, and what it all means for the future of the industry.Rounding out the episode, the team discusses the unintended consequences of the AI boom—like global hardware shortages stretching beyond GPUs to hard drives—and examines emerging prompt injection attack techniques, highlighting real-world examples and the growing security risks surrounding AI-powered tools.Join us LIVE on Mondays, 4:30pm EST.A weekly Podcast with BHIS and Friends. We discuss notable Infosec, and infosec-adjacent news stories gathered by our community news team.https://www.youtube.com/@BlackHillsInformationSecurityChat with us on Discord! - https://discord.gg/bhis

In this episode of The Effortless Podcast, Dheeraj Pandey speaks with Dr. Abhishek Bhowmick about how quantum mechanics reshaped our understanding of determinism and why that shift matters for AI today.  From the Einstein–Bohr debates to the idea that nature is fundamentally probabilistic, they explore how the collapse of “if-then” thinking began nearly a century ago. The discussion draws parallels between quantum superposition and modern LLM behavior. At its core, the episode reframes AI as a rediscovery of how reality computes. The conversation then moves from physics to computing architecture, tracing the evolution from scalar CPUs to GPUs, TPUs, tensors, and eventually quantum computing. They examine why probabilistic systems and vector math feel more natural than purely deterministic software. Hybrid computing models show that classical systems still matter. The episode also unpacks what quantum computers are truly good at, especially in cryptography and simulation. Ultimately, it reflects on whether the future of computing lies in embracing probability rather than resisting it. Key Topics & Timestamps 00:00 – Welcome, context, and how Dheeraj & Abhishek met 04:00 – Abhishek's journey: IIT, Princeton, Apple, Snowflake 08:00 – The 1927 Solvay Conference and physics at a crossroads 12:00 – Einstein vs. Bohr: determinism vs. probability 16:00 – Superposition and the collapse of the wave function 20:00 – Fields vs. particles: what is an electron really? 25:00 – Matter particles, force particles, and the Standard Model 30:00 – Transistors, voltage, and the rise of deterministic computing 35:00 – From scalar CPUs to vectors and matrices 40:00 – Tensors, linear algebra, and modern AI systems 45:00 – Principle of Least Action and gradient descent parallels 50:00 – Hallucinations, probability mass, and LLM behavior 55:00 – Vector databases, embeddings, and KNN search 59:00 – GPUs vs. TPUs: matrix vs. tensor architectures 1:05:00 – What quantum computers are actually good at 1:10:00 – Post-quantum cryptography and the future of computing Host -  Dheeraj Pandey Co-founder & CEO at DevRev. Former Co-founder & CEO of Nutanix. A systems thinker and product visionary focused on AI, software architecture, and the future of work. Guest -  Dr Abhishek Bhowmick                                                                                                                                                                                                                Co-Founder and CTO of Samooha, a secure data collaboration platform acquired by Snowflake. He previously worked at Apple as Head of ML Privacy and Cryptography, System Intelligence, and Machine Learning, and earlier at Goldman Sachs. He attended Princeton University and was awarded IIT Kanpur's Young Alumnus Award in 2024. Follow the Host and Guest - Dheeraj Pandey: LinkedIn - https://www.linkedin.com/in/dpandey Twitter - https://x.com/dheeraj Abhishek Bhowmik  LinkedIn –  https://www.linkedin.com/in/ab-abhishek-bhowmick Twitter/X – https://x.com/bhowmick_ab Share Your Thoughts Have questions, comments, or ideas for future episodes?

O mercado de notebooks está passando por uma transformação importante. O aumento global no custo de componentes, como memórias e placas de vídeo, já começa a impactar preços e estratégias das fabricantes. Ao mesmo tempo, a chegada de novas GPUs e a popularização da inteligência artificial nos computadores prometem mudar o perfil de consumo nos próximos anos. No novo episódio do Podcast Canaltech, o repórter Diego Corumba conversa com Vladimir Rissardi, CEO da Avell Notebooks, sobre o cenário atual do setor. A entrevista aborda desde a demanda por máquinas gamer com GPUs RTX série 50 até a expansão do mercado corporativo e a tendência de renovação de computadores após o boom da pandemia. O episódio também explica como a inteligência artificial deve influenciar a próxima geração de hardware e por que os consumidores podem começar a ver mudanças nos preços e nas configurações disponíveis. Você também vai conferir: Adidas investiga possível vazamento de dados, China quer obrigar botões físicos nos carros e SOS do iPhone ajuda em resgate após avalanche. Este podcast foi roteirizado e apresentado por Fernada Santos e contou com reportagens de Jaqueline Sousa, Danielle Casstina e Vinicius Moschen, sob coordenação de Anaísa Catucci. A trilha sonora é de Guilherme Zomer, a edição de Natália Improta e a arte da capa é de Erick Teixeira.See omnystudio.com/listener for privacy information.

Anshel Sag hosts episode 242 of the rebranded 6G Podcast and introduces new co-host Mike Dano (Ookla), noting the industry's “5G lull” and a shift toward 6G discussions. They discuss 5G Americas shutting down operations after years as a spectrum- and standards-focused trade association, framing the closure as a sign of cooling 5G interest and flat-to-negative RAN sales. Anshel covers Samsung and KT achieving a 3 Gbps downlink in 7 GHz using Keysight 6G test equipment and X-MIMO, noting the unclear bandwidth used and emphasizing that 6G progress is still largely experimental with mixed commercialization timelines (2028–2030). They debate 7 GHz as a key 6G band, propagation challenges (referencing Wi‑Fi 6E/7), the fading focus on terahertz bands, China's earlier stance on 6 GHz, and potential limited initial 6G deployments. Mike highlights an Ookla report on 5G standalone showing improved battery life versus NSA (EE +22%, O2 +11%) and argues operators under-market SA benefits. Anshel explains T-Mobile's John Saw concept of “kinetic tokens” for low-latency AI in motion (physical AI) across device/edge/cloud, tying it to use cases like real-time translation (5G Advanced, 50 languages) and ISAC for tracking and supporting drones, plus discussion of NVIDIA-based AI-RAN strategies and skepticism about cost and monetization of GPUs in base stations. Mike raises broader concerns about the AI data center boom, citing a projected $710B hyperscaler investment in 2026, power constraints (natural gas, gas turbines/jet engines), private high-bandwidth inter-data-center traffic, and questions about whether telecoms can capture AI value versus hyperscalers, while noting sovereign AI opportunities in countries with fewer data centers. They close with Microsoft and Ericsson integrating Ericsson Advanced Enterprise Mobility into Windows 11 (piloted on Surface 5G) to simplify secure enterprise 5G laptop management with Intune and eSIM provisioning, and discuss why cellular laptops haven't broadly taken off (cost, plans, coverage) and how Apple's modems and multi-carrier services might change adoption.00:00 Welcome & New Co-Host Mike Dano Joins the 6G Podcast01:10 Why the Rebrand Now: 5G Lull, MWC & Samsung Unpacked Tease02:03 5G Americas Shuts Down: What It Says About the Market Cycle05:41 Samsung + KT Hit 3 Gbps in 7 GHz: Early 6G Trial Reality Check07:32 Where 6G Spectrum Lands: 7 GHz, Propagation, and Terahertz Hype Fades12:58 Ookla Report Spotlight: 5G Standalone Boosts Battery Life (and Why It Matters)17:54 Kinetic Tokens & Physical AI: T-Mobile's Vision for Low-Latency 6G22:51 Is T-Mobile's “GPU in Every Base Station” Plan Actually Viable?24:16 The Edge Compute Case: Double-Dipping GPUs for AI + XR Graphics26:29 AI Wearables, AR Glasses, and Why 6G Timing Could Favor T-Mobile28:27 The $710B Data Center Boom: What Hyperscaler Spend Means for Telecom30:36 Powering AI: Natural Gas, Turbines, and the Nuclear Buildout Debate31:25 Neo-Clouds & AI Transport: Private Backbone Links, Akamai GPU Rentals, and Wall Street Doubts37:40 Microsoft + Ericsson Bring Enterprise 5G Management Natively to Windows 1140:00 Why 5G Laptops Still Haven't Taken Off (Cost, Plans, Battery, Coverage)41:41 What Changes in 6G: Apple Modems, Multi-Carrier Service, and the Road Ahead (Wrap-Up)

The bottleneck in AI isn't compute anymore, it's the network. In this video, I sit down with Martin, the architect behind Cisco's Silicon One, to discuss the massive leap to 100 Terabits per second. We go deep into the silicon level to understand how "intelligent agents" embedded in the hardware are solving the packet loss problem for massive AI training clusters. We cover the new 1.6T Linear Pluggable Optics (LPO), why Cisco is becoming the "Apple of Networking" by building their own full stack, and why they believe Ethernet has officially won the data center war. Topics Covered: • Cisco Silicon One: The architecture behind the 100Tbps & 51.2Tbps chips. • AI Scale: How to interconnect 128,000 GPUs without stalling. • Hardware Agents: Real-time traffic rerouting at the silicon level. • 1.6Tbps Optics: Moving DSPs out of the module to save power (LPO). • Ethernet vs. InfiniBand: Why standard Ethernet is winning in AI. Big thank you to ‪@Cisco‬ for sponsoring my trip to Cisco Live Amsterdam! // Martin Lund SOCIALS // LinkedIn: / martinlundca // Website REFERENCE // https://blogs.cisco.com/sp/cisco-sili... // David's SOCIAL // Discord: discord.com/invite/usKSyzb Twitter: www.twitter.com/davidbombal Instagram: www.instagram.com/davidbombal LinkedIn: www.linkedin.com/in/davidbombal Facebook: www.facebook.com/davidbombal.co TikTok: tiktok.com/@davidbombal YouTube: / @davidbombal Spotify: open.spotify.com/show/3f6k6gE... SoundCloud: / davidbombal Apple Podcast: podcasts.apple.com/us/podcast... // MY STUFF // https://www.amazon.com/shop/davidbombal // SPONSORS // Interested in sponsoring my videos? Reach out to my team here: sponsors@davidbombal.com // MENU // 0:00 - Coming Up 01:09 - Intro 01:42 - Cisco's New Announcement (G200 Chip) 02:32 - How Many Companies Are Doing This? 05:02 - Is Cisco The 'Apple' Of Networking? 07:30 - Intelligent Collective Networking 08:09 - Who Designed The Chip? 08:56 - Cisco's New Optical Module 09:59 - Why Do We Need These Speeds? 15:46 - Data Center Scale 16:50 - Cisco Switches 19:16 - Who Is The Target Audience? 20:23 - Linear Pluggable Optics (LPO) 22:04 – Conclusion Please note that links listed may be affiliate links and provide me with a small percentage/kickback should you use them to purchase any of the items listed or recommended. Thank you for supporting me and this channel! Disclaimer: This video is for educational purposes only. #cisco #ciscolive #ciscoemea

This Week In Startups is made possible by:Gusto - Try Gusto today and get 3 months free at http://uber.com/ai-solutionsCrusoe Cloud - Reserve your capacity for the latest GPU's at http://uber.com/ai-solutionsUber AI Solutions - Book a demo today at http://uber.com/ai-solutions*Today's show: It's a packed show! We've got YouTuber and Openclaw enthusiast Matthew Berman, Ryan Yaneli, founder of Nextvisit, and Jason Grad, founder of Massive! We're all in on Openclaw, but we have no doubts there's still room in the market for a GIANT Openclaw consumer app to shift the paradigm. What will that look like? Will it be an app? Will it be baked into the iPhone? Let's explore!**Timestamps:* 00:00 Intro02:04 Why Matthew thinks Openclaw is not ready yet to be brought to the consumer04:45 Jason doesn't want hundreds of different apps, and thousands of tabs05:45 Why Ryan sees open claw giving consumers access to opportunities they couldn't have gotten to otherwise.07:02 Only 10% of people are technical enough to install openclaw08:16 Would Openclaw be better off as an app?08:27 *Gusto*. Check out the online payroll and benefits experts with software built specifically for small business and startups. Try Gusto today and get three months FREE at [Uber.com/twist](http://uber.com/ai-solutions)00:10:52 The killer use case that could bring Openclaw to the consumer00:12:13 Why Meta acquired Manus.00:15:13 How Ryan uses Openclaw in his personal life00:18:44 *Crusoe Cloud*: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit crusoe.ai/savings to reserve your capacity for the latest GPUs today.00:23:24 What Jason's “Clawpod” does00:24:38 Jason demos his Openclaw workflow00:28:23 *Uber AI Solutions -* Your trusted partner to get AI to work in the real world. Book a demo with them TODAY at http://uber.com/ai-solutions00:30:04 How Matt used Openclaw to figure out he's been having stomach issues00:32:27 What will be the ultimate UX for AI?00:38:53 Anthropic has patched the ability to use Openclaw through its pro plan!00:42:20 Matt and Jason hope for a multi-model future — but we haven't made progress!00:52:21 Jason has skepticisms about the Openclaw foundation00:52:59 Ryan predicts a new Openclaw fork coming from the shadows!00:54:21 Peter Steinberger is going to OpenAI, NOT to work with Openclaw… Will he “orphan” openclaw?00:58:19 does raspberry AI stand a chance against Apple?*Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/Check out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcp*Follow Lon:X: https://x.com/lons*Follow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis*Thank you to our partners:*Gusto*. Check out the online payroll and benefits experts with software built specifically for small business and startups. Try Gusto today and get three months FREE at [Uber.com/twist](http://uber.com/ai-solutions)*Crusoe Cloud*: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit [crusoe.ai/savings] to reserve your capacity for the latest GPUs today.*Uber AI Solutions -* Your trusted partner to get AI to work in the real world. Book a demo with them TODAY at [Uber.com/twist](http://uber.com/ai-solutions)Check out all our partner offers: https://partners.launch.co/*Check out Jason's suite of newsletters: https://substack.com/@calacanis*Follow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: [https://www.instagram.com/thisweekinstartups](https://www.instagram.com/thisweekinstartups/)TikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: [https://twistartups.substack.com](https://twistartups.substack.com/)

What does it take to design a programming language from scratch when the target isn't just CPUs, but GPUs, accelerators, and the entire AI stack? In this episode, I sit down with legendary language architect Chris Lattner to talk about Mojo — his ambitious attempt to rethink systems programming for the machine learning era. We trace the arc from LLVM and Clang to Swift and now Mojo, unpacking the lessons Chris has carried forward into this new language. Mojo aims to combine Python's ergonomics with C-level performance, but the real story is deeper: memory ownership, heterogeneous compute, compile-time metaprogramming, and giving developers precise control over how AI workloads hit silicon. Chris shares the motivation behind Modular, why today's AI infrastructure demands new abstractions, and how Mojo fits into a rapidly evolving ecosystem of ML frameworks and hardware backends. We also dig into developer experience, safety vs performance tradeoffs, and what it means to build a language that spans research notebooks all the way down to kernel-level execution.

Most companies don't realize it yet, but the way they built their technology foundations is quietly becoming a liability.Cloud costs are rising. Platforms change underneath you. AI is reshaping infrastructure from hardware to data to governance. And the strategies that once felt “safe” are now the ones creating the most risk.In this episode of IT Visionaries, host Chris Brandt sits down with Mano Bhattacharya, CTO of Nutanix, to unpack what's really happening inside enterprise technology right now. This isn't a conversation about chasing the newest tools or betting on a single future. It's about why adaptability has become the most important design principle in modern tech.Mano explains why many organizations are rethinking long-held assumptions about virtualization, cloud, and containers, and why the smartest teams are building infrastructure that gives them options over the next three to five years. They explore how AI changes the entire stack, not just applications, why data has become the real bottleneck, and why moving fast without a coherent plan can be more dangerous than moving slowly. Chapters:00:00 - The VMware Exodus Wave is Coming03:34 - VMware Broadcom Acquisition: What Changed and Why It Matters05:56 - Three Migration Paths: Stay, Move to Cloud, or Modernize09:59 - Why Containers on VMs Make Sense for Most Enterprises15:40 - The Five Stages of VMware Migration Grief21:20 - VMware Admin to Nutanix Admin: Closing the Skills Gap24:14 - The Cloud-in-a-Box Philosophy: From Boxes to Software32:30 - Opening Up the Platform: Pure Storage and Third-Party Integrations40:54 - AI Infrastructure: The End-to-End Challenge48:01 - Enterprise AI Strategy: Use Cases, Economics, and Governance56:44 - What's Next: Building the Invisible Platform for AI  -- This episode of IT Visionaries is brought to you by Meter - the company building better networks. Businesses today are frustrated with outdated providers, rigid pricing, and fragmented tools. Meter changes that with a single integrated solution that covers everything wired, wireless, and even cellular networking. They design the hardware, write the firmware, build the software, and manage it all so your team doesn't have to.That means you get fast, secure, and scalable connectivity without the complexity of juggling multiple providers. Thanks to meter for sponsoring. Go to meter.com/itv to book a demo.---IT Visionaries is made by the team at Mission.org. Learn more about our media studio and network of podcasts at mission.org. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Tickets for AIEi Miami and AIE Europe are live, with first wave speakers announced!From pioneering software-defined networking to backing many of the most aggressive AI model companies of this cycle, Martin Casado and Sarah Wang sit at the center of the capital, compute, and talent arms race reshaping the tech industry. As partners at a16z investing across infrastructure and growth, they've watched venture and growth blur, model labs turn dollars into capability at unprecedented speed, and startups raise nine-figure rounds before monetization.Martin and Sarah join us to unpack the new financing playbook for AI: why today's rounds are really compute contracts in disguise, how the “raise → train → ship → raise bigger” flywheel works, and whether foundation model companies can outspend the entire app ecosystem built on top of them. They also share what's underhyped (boring enterprise software), what's overheated (talent wars and compensation spirals), and the two radically different futures they see for AI's market structure.We discuss:* Martin's “two futures” fork: infinite fragmentation and new software categories vs. a small oligopoly of general models that consume everything above them* The capital flywheel: how model labs translate funding directly into capability gains, then into revenue growth measured in weeks, not years* Why venture and growth have merged: $100M–$1B hybrid rounds, strategic investors, compute negotiations, and complex deal structures* The AGI vs. product tension: allocating scarce GPUs between long-term research and near-term revenue flywheels* Whether frontier labs can out-raise and outspend the entire app ecosystem built on top of their APIs* Why today's talent wars ($10M+ comp packages, $B acqui-hires) are breaking early-stage founder math* Cursor as a case study: building up from the app layer while training down into your own models* Why “boring” enterprise software may be the most underinvested opportunity in the AI mania* Hardware and robotics: why the ChatGPT moment hasn't yet arrived for robots and what would need to change* World Labs and generative 3D: bringing the marginal cost of 3D scene creation down by orders of magnitude* Why public AI discourse is often wildly disconnected from boardroom reality and how founders should navigate the noiseShow Notes:* “Where Value Will Accrue in AI: Martin Casado & Sarah Wang” - a16z show* “Jack Altman & Martin Casado on the Future of Venture Capital”* World Labs—Martin Casado• LinkedIn: https://www.linkedin.com/in/martincasado/• X: https://x.com/martin_casadoSarah Wang• LinkedIn: https://www.linkedin.com/in/sarah-wang-59b96a7• X: https://x.com/sarahdingwanga16z• https://a16z.com/Timestamps00:00:00 – Intro: Live from a16z00:01:20 – The New AI Funding Model: Venture + Growth Collide00:03:19 – Circular Funding, Demand & “No Dark GPUs”00:05:24 – Infrastructure vs Apps: The Lines Blur00:06:24 – The Capital Flywheel: Raise → Train → Ship → Raise Bigger00:09:39 – Can Frontier Labs Outspend the Entire App Ecosystem?00:11:24 – Character AI & The AGI vs Product Dilemma00:14:39 – Talent Wars, $10M Engineers & Founder Anxiety00:17:33 – What's Underinvested? The Case for “Boring” Software00:19:29 – Robotics, Hardware & Why It's Hard to Win00:22:42 – Custom ASICs & The $1B Training Run Economics00:24:23 – American Dynamism, Geography & AI Power Centers00:26:48 – How AI Is Changing the Investor Workflow (Claude Cowork)00:29:12 – Two Futures of AI: Infinite Expansion or Oligopoly?00:32:48 – If You Can Raise More Than Your Ecosystem, You Win00:34:27 – Are All Tasks AGI-Complete? Coding as the Test Case00:38:55 – Cursor & The Power of the App Layer00:44:05 – World Labs, Spatial Intelligence & 3D Foundation Models00:47:20 – Thinking Machines, Founder Drama & Media Narratives00:52:30 – Where Long-Term Power Accrues in the AI StackTranscriptLatent.Space - Inside AI's $10B+ Capital Flywheel — Martin Casado & Sarah Wang of a16z[00:00:00] Welcome to Latent Space (Live from a16z) + Meet the Guests[00:00:00] Alessio: Hey everyone. Welcome to the Latent Space podcast, live from a 16 z. Uh, this is Alessio founder Kernel Lance, and I'm joined by Twix, editor of Latent Space.[00:00:08] swyx: Hey, hey, hey. Uh, and we're so glad to be on with you guys. Also a top AI podcast, uh, Martin Cado and Sarah Wang. Welcome, very[00:00:16] Martin Casado: happy to be here and welcome.[00:00:17] swyx: Yes, uh, we love this office. We love what you've done with the place. Uh, the new logo is everywhere now. It's, it's still getting, takes a while to get used to, but it reminds me of like sort of a callback to a more ambitious age, which I think is kind of[00:00:31] Martin Casado: definitely makes a statement.[00:00:33] swyx: Yeah.[00:00:34] Martin Casado: Not quite sure what that statement is, but it makes a statement.[00:00:37] swyx: Uh, Martin, I go back with you to Netlify.[00:00:40] Martin Casado: Yep.[00:00:40] swyx: Uh, and, uh, you know, you create a software defined networking and all, all that stuff people can read up on your background. Yep. Sarah, I'm newer to you. Uh, you, you sort of started working together on AI infrastructure stuff.[00:00:51] Sarah Wang: That's right. Yeah. Seven, seven years ago now.[00:00:53] Martin Casado: Best growth investor in the entire industry.[00:00:55] swyx: Oh, say[00:00:56] Martin Casado: more hands down there is, there is. [00:01:00] I mean, when it comes to AI companies, Sarah, I think has done the most kind of aggressive, um, investment thesis around AI models, right? So, worked for Nom Ja, Mira Ia, FEI Fey, and so just these frontier, kind of like large AI models.[00:01:15] I think, you know, Sarah's been the, the broadest investor. Is that fair?[00:01:20] Venture vs. Growth in the Frontier Model Era[00:01:20] Sarah Wang: No, I, well, I was gonna say, I think it's been a really interesting tag, tag team actually just ‘cause the, a lot of these big C deals, not only are they raising a lot of money, um, it's still a tech founder bet, which obviously is inherently early stage.[00:01:33] But the resources,[00:01:36] Martin Casado: so many, I[00:01:36] Sarah Wang: was gonna say the resources one, they just grow really quickly. But then two, the resources that they need day one are kind of growth scale. So I, the hybrid tag team that we have is. Quite effective, I think,[00:01:46] Martin Casado: what is growth these days? You know, you don't wake up if it's less than a billion or like, it's, it's actually, it's actually very like, like no, it's a very interesting time in investing because like, you know, take like the character around, right?[00:01:59] These tend to [00:02:00] be like pre monetization, but the dollars are large enough that you need to have a larger fund and the analysis. You know, because you've got lots of users. ‘cause this stuff has such high demand requires, you know, more of a number sophistication. And so most of these deals, whether it's US or other firms on these large model companies, are like this hybrid between venture growth.[00:02:18] Sarah Wang: Yeah. Total. And I think, you know, stuff like BD for example, you wouldn't usually need BD when you were seed stage trying to get market biz Devrel. Biz Devrel, exactly. Okay. But like now, sorry, I'm,[00:02:27] swyx: I'm not familiar. What, what, what does biz Devrel mean for a venture fund? Because I know what biz Devrel means for a company.[00:02:31] Sarah Wang: Yeah.[00:02:32] Compute Deals, Strategics, and the ‘Circular Funding' Question[00:02:32] Sarah Wang: You know, so a, a good example is, I mean, we talk about buying compute, but there's a huge negotiation involved there in terms of, okay, do you get equity for the compute? What, what sort of partner are you looking at? Is there a go-to market arm to that? Um, and these are just things on this scale, hundreds of millions, you know, maybe.[00:02:50] Six months into the inception of a company, you just wouldn't have to negotiate these deals before.[00:02:54] Martin Casado: Yeah. These large rounds are very complex now. Like in the past, if you did a series A [00:03:00] or a series B, like whatever, you're writing a 20 to a $60 million check and you call it a day. Now you normally have financial investors and strategic investors, and then the strategic portion always still goes with like these kind of large compute contracts, which can take months to do.[00:03:13] And so it's, it's very different ties. I've been doing this for 10 years. It's the, I've never seen anything like this.[00:03:19] swyx: Yeah. Do you have worries about the circular funding from so disease strategics?[00:03:24] Martin Casado: I mean, listen, as long as the demand is there, like the demand is there. Like the problem with the internet is the demand wasn't there.[00:03:29] swyx: Exactly. All right. This, this is like the, the whole pyramid scheme bubble thing, where like, as long as you mark to market on like the notional value of like, these deals, fine, but like once it starts to chip away, it really Well[00:03:41] Martin Casado: no, like as, as, as, as long as there's demand. I mean, you know, this, this is like a lot of these sound bites have already become kind of cliches, but they're worth saying it.[00:03:47] Right? Like during the internet days, like we were. Um, raising money to put fiber in the ground that wasn't used. And that's a problem, right? Because now you actually have a supply overhang.[00:03:58] swyx: Mm-hmm.[00:03:59] Martin Casado: And even in the, [00:04:00] the time of the, the internet, like the supply and, and bandwidth overhang, even as massive as it was in, as massive as the crash was only lasted about four years.[00:04:09] But we don't have a supply overhang. Like there's no dark GPUs, right? I mean, and so, you know, circular or not, I mean, you know, if, if someone invests in a company that, um. You know, they'll actually use the GPUs. And on the other side of it is the, is the ask for customer. So I I, I think it's a different time.[00:04:25] Sarah Wang: I think the other piece, maybe just to add onto this, and I'm gonna quote Martine in front of him, but this is probably also a unique time in that. For the first time, you can actually trace dollars to outcomes. Yeah, right. Provided that scaling laws are, are holding, um, and capabilities are actually moving forward.[00:04:40] Because if you can put translate dollars into capabilities, uh, a capability improvement, there's demand there to martine's point. But if that somehow breaks, you know, obviously that's an important assumption in this whole thing to make it work. But you know, instead of investing dollars into sales and marketing, you're, you're investing into r and d to get to the capability, um, you know, increase.[00:04:59] And [00:05:00] that's sort of been the demand driver because. Once there's an unlock there, people are willing to pay for it.[00:05:05] Alessio: Yeah.[00:05:06] Blurring Lines: Models as Infra + Apps, and the New Fundraising Flywheel[00:05:06] Alessio: Is there any difference in how you built the portfolio now that some of your growth companies are, like the infrastructure of the early stage companies, like, you know, OpenAI is now the same size as some of the cloud providers were early on.[00:05:16] Like what does that look like? Like how much information can you feed off each other between the, the two?[00:05:24] Martin Casado: There's so many lines that are being crossed right now, or blurred. Right. So we already talked about venture and growth. Another one that's being blurred is between infrastructure and apps, right? So like what is a model company?[00:05:35] Mm-hmm. Like, it's clearly infrastructure, right? Because it's like, you know, it's doing kind of core r and d. It's a horizontal platform, but it's also an app because it's um, uh, touches the users directly. And then of course. You know, the, the, the growth of these is just so high. And so I actually think you're just starting to see a, a, a new financing strategy emerge and, you know, we've had to adapt as a result of that.[00:05:59] And [00:06:00] so there's been a lot of changes. Um, you're right that these companies become platform companies very quickly. You've got ecosystem build out. So none of this is necessarily new, but the timescales of which it's happened is pretty phenomenal. And the way we'd normally cut lines before is blurred a little bit, but.[00:06:16] But that, that, that said, I mean, a lot of it also just does feel like things that we've seen in the past, like cloud build out the internet build out as well.[00:06:24] Sarah Wang: Yeah. Um, yeah, I think it's interesting, uh, I don't know if you guys would agree with this, but it feels like the emerging strategy is, and this builds off of your other question, um.[00:06:33] You raise money for compute, you pour that or you, you pour the money into compute, you get some sort of breakthrough. You funnel the breakthrough into your vertically integrated application. That could be chat GBT, that could be cloud code, you know, whatever it is. You massively gain share and get users.[00:06:49] Maybe you're even subsidizing at that point. Um, depending on your strategy. You raise money at the peak momentum and then you repeat, rinse and repeat. Um, and so. And that wasn't [00:07:00] true even two years ago, I think. Mm-hmm. And so it's sort of to your, just tying it to fundraising strategy, right? There's a, and hiring strategy.[00:07:07] All of these are tied, I think the lines are blurring even more today where everyone is, and they, but of course these companies all have API businesses and so they're these, these frenemy lines that are getting blurred in that a lot of, I mean, they have billions of dollars of API revenue, right? And so there are customers there.[00:07:23] But they're competing on the app layer.[00:07:24] Martin Casado: Yeah. So this is a really, really important point. So I, I would say for sure, venture and growth, that line is blurry app and infrastructure. That line is blurry. Um, but I don't think that that changes our practice so much. But like where the very open questions are like, does this layer in the same way.[00:07:43] Compute traditionally has like during the cloud is like, you know, like whatever, somebody wins one layer, but then another whole set of companies wins another layer. But that might not, might not be the case here. It may be the case that you actually can't verticalize on the token string. Like you can't build an app like it, it necessarily goes down just because there are no [00:08:00] abstractions.[00:08:00] So those are kinda the bigger existential questions we ask. Another thing that is very different this time than in the history of computer sciences is. In the past, if you raised money, then you basically had to wait for engineering to catch up. Which famously doesn't scale like the mythical mammoth. It take a very long time.[00:08:18] But like that's not the case here. Like a model company can raise money and drop a model in a, in a year, and it's better, right? And, and it does it with a team of 20 people or 10 people. So this type of like money entering a company and then producing something that has demand and growth right away and using that to raise more money is a very different capital flywheel than we've ever seen before.[00:08:39] And I think everybody's trying to understand what the consequences are. So I think it's less about like. Big companies and growth and this, and more about these more systemic questions that we actually don't have answers to.[00:08:49] Alessio: Yeah, like at Kernel Labs, one of our ideas is like if you had unlimited money to spend productively to turn tokens into products, like the whole early stage [00:09:00] market is very different because today you're investing X amount of capital to win a deal because of price structure and whatnot, and you're kind of pot committing.[00:09:07] Yeah. To a certain strategy for a certain amount of time. Yeah. But if you could like iteratively spin out companies and products and just throw, I, I wanna spend a million dollar of inference today and get a product out tomorrow.[00:09:18] swyx: Yeah.[00:09:19] Alessio: Like, we should get to the point where like the friction of like token to product is so low that you can do this and then you can change the Right, the early stage venture model to be much more iterative.[00:09:30] And then every round is like either 100 k of inference or like a hundred million from a 16 Z. There's no, there's no like $8 million C round anymore. Right.[00:09:38] When Frontier Labs Outspend the Entire App Ecosystem[00:09:38] Martin Casado: But, but, but, but there's a, there's a, the, an industry structural question that we don't know the answer to, which involves the frontier models, which is, let's take.[00:09:48] Anthropic it. Let's say Anthropic has a state-of-the-art model that has some large percentage of market share. And let's say that, uh, uh, uh, you know, uh, a company's building smaller models [00:10:00] that, you know, use the bigger model in the background, open 4.5, but they add value on top of that. Now, if Anthropic can raise three times more.[00:10:10] Every subsequent round, they probably can raise more money than the entire app ecosystem that's built on top of it. And if that's the case, they can expand beyond everything built on top of it. It's like imagine like a star that's just kind of expanding, so there could be a systemic. There could be a, a systemic situation where the soda models can raise so much money that they can out pay anybody that bills on top of ‘em, which would be something I don't think we've ever seen before just because we were so bottlenecked in engineering, and this is a very open question.[00:10:41] swyx: Yeah. It's, it is almost like bitter lesson applied to the startup industry.[00:10:45] Martin Casado: Yeah, a hundred percent. It literally becomes an issue of like raise capital, turn that directly into growth. Use that to raise three times more. Exactly. And if you can keep doing that, you literally can outspend any company that's built the, not any company.[00:10:57] You can outspend the aggregate of companies on top of [00:11:00] you and therefore you'll necessarily take their share, which is crazy.[00:11:02] swyx: Would you say that kind of happens in character? Is that the, the sort of postmortem on. What happened?[00:11:10] Sarah Wang: Um,[00:11:10] Martin Casado: no.[00:11:12] Sarah Wang: Yeah, because I think so,[00:11:13] swyx: I mean the actual postmortem is, he wanted to go back to Google.[00:11:15] Exactly. But like[00:11:18] Martin Casado: that's another difference that[00:11:19] Sarah Wang: you said[00:11:21] Martin Casado: it. We should talk, we should actually talk about that.[00:11:22] swyx: Yeah,[00:11:22] Sarah Wang: that's[00:11:23] swyx: Go for it. Take it. Take,[00:11:23] Sarah Wang: yeah.[00:11:24] Character.AI, Founder Goals (AGI vs Product), and GPU Allocation Tradeoffs[00:11:24] Sarah Wang: I was gonna say, I think, um. The, the, the character thing raises actually a different issue, which actually the Frontier Labs will face as well. So we'll see how they handle it.[00:11:34] But, um, so we invest in character in January, 2023, which feels like eons ago, I mean, three years ago. Feels like lifetimes ago. But, um, and then they, uh, did the IP licensing deal with Google in August, 2020. Uh, four. And so, um, you know, at the time, no, you know, he's talked publicly about this, right? He wanted to Google wouldn't let him put out products in the world.[00:11:56] That's obviously changed drastically. But, um, he went to go do [00:12:00] that. Um, but he had a product attached. The goal was, I mean, it's Nome Shair, he wanted to get to a GI. That was always his personal goal. But, you know, I think through collecting data, right, and this sort of very human use case, that the character product.[00:12:13] Originally was and still is, um, was one of the vehicles to do that. Um, I think the real reason that, you know. I if you think about the, the stress that any company feels before, um, you ultimately going one way or the other is sort of this a GI versus product. Um, and I think a lot of the big, I think, you know, opening eyes, feeling that, um, anthropic if they haven't started, you know, felt it, certainly given the success of their products, they may start to feel that soon.[00:12:39] And the real. I think there's real trade-offs, right? It's like how many, when you think about GPUs, that's a limited resource. Where do you allocate the GPUs? Is it toward the product? Is it toward new re research? Right? Is it, or long-term research, is it toward, um, n you know, near to midterm research? And so, um, in a case where you're resource constrained, um, [00:13:00] of course there's this fundraising game you can play, right?[00:13:01] But the fund, the market was very different back in 2023 too. Um. I think the best researchers in the world have this dilemma of, okay, I wanna go all in on a GI, but it's the product usage revenue flywheel that keeps the revenue in the house to power all the GPUs to get to a GI. And so it does make, um, you know, I think it sets up an interesting dilemma for any startup that has trouble raising up until that level, right?[00:13:27] And certainly if you don't have that progress, you can't continue this fly, you know, fundraising flywheel.[00:13:32] Martin Casado: I would say that because, ‘cause we're keeping track of all of the things that are different, right? Like, you know, venture growth and uh, app infra and one of the ones is definitely the personalities of the founders.[00:13:45] It's just very different this time I've been. Been doing this for a decade and I've been doing startups for 20 years. And so, um, I mean a lot of people start this to do a GI and we've never had like a unified North star that I recall in the same [00:14:00] way. Like people built companies to start companies in the past.[00:14:02] Like that was what it was. Like I would create an internet company, I would create infrastructure company, like it's kind of more engineering builders and this is kind of a different. You know, mentality. And some companies have harnessed that incredibly well because their direction is so obviously on the path to what somebody would consider a GI, but others have not.[00:14:20] And so like there is always this tension with personnel. And so I think we're seeing more kind of founder movement.[00:14:27] Sarah Wang: Yeah.[00:14:27] Martin Casado: You know, as a fraction of founders than we've ever seen. I mean, maybe since like, I don't know the time of like Shockly and the trade DUR aid or something like that. Way back in the beginning of the industry, I, it's a very, very.[00:14:38] Unusual time of personnel.[00:14:39] Sarah Wang: Totally.[00:14:40] Talent Wars, Mega-Comp, and the Rise of Acquihire M&A[00:14:40] Sarah Wang: And it, I think it's exacerbated by the fact that talent wars, I mean, every industry has talent wars, but not at this magnitude, right? No. Yeah. Very rarely can you see someone get poached for $5 billion. That's hard to compete with. And then secondly, if you're a founder in ai, you could fart and it would be on the front page of, you know, the information these days.[00:14:59] And so there's [00:15:00] sort of this fishbowl effect that I think adds to the deep anxiety that, that these AI founders are feeling.[00:15:06] Martin Casado: Hmm.[00:15:06] swyx: Uh, yes. I mean, just on, uh, briefly comment on the founder, uh, the sort of. Talent wars thing. I feel like 2025 was just like a blip. Like I, I don't know if we'll see that again.[00:15:17] ‘cause meta built the team. Like, I don't know if, I think, I think they're kind of done and like, who's gonna pay more than meta? I, I don't know.[00:15:23] Martin Casado: I, I agree. So it feels so, it feel, it feels this way to me too. It's like, it is like, basically Zuckerberg kind of came out swinging and then now he's kind of back to building.[00:15:30] Yeah,[00:15:31] swyx: yeah. You know, you gotta like pay up to like assemble team to rush the job, whatever. But then now, now you like you, you made your choices and now they got a ship.[00:15:38] Martin Casado: I mean, the, the o other side of that is like, you know, like we're, we're actually in the job hiring market. We've got 600 people here. I hire all the time.[00:15:44] I've got three open recs if anybody's interested, that's listening to this for investor. Yeah, on, on the team, like on the investing side of the team, like, and, um, a lot of the people we talk to have acting, you know, active, um, offers for 10 million a year or something like that. And like, you know, and we pay really, [00:16:00] really well.[00:16:00] And just to see what's out on the market is really, is really remarkable. And so I would just say it's actually, so you're right, like the really flashy one, like I will get someone for, you know, a billion dollars, but like the inflated, um, uh, trickles down. Yeah, it is still very active today. I mean,[00:16:18] Sarah Wang: yeah, you could be an L five and get an offer in the tens of millions.[00:16:22] Okay. Yeah. Easily. Yeah. It's so I think you're right that it felt like a blip. I hope you're right. Um, but I think it's been, the steady state is now, I think got pulled up. Yeah. Yeah. I'll pull up for[00:16:31] Martin Casado: sure. Yeah.[00:16:32] Alessio: Yeah. And I think that's breaking the early stage founder math too. I think before a lot of people would be like, well, maybe I should just go be a founder instead of like getting paid.[00:16:39] Yeah. 800 KA million at Google. But if I'm getting paid. Five, 6 million. That's different but[00:16:45] Martin Casado: on. But on the other hand, there's more strategic money than we've ever seen historically, right? Mm-hmm. And so, yep. The economics, the, the, the, the calculus on the economics is very different in a number of ways. And, uh, it's crazy.[00:16:58] It's cra it's causing like a, [00:17:00] a, a, a ton of change in confusion in the market. Some very positive, sub negative, like, so for example, the other side of the, um. The co-founder, like, um, acquisition, you know, mark Zuckerberg poaching someone for a lot of money is like, we were actually seeing historic amount of m and a for basically acquihires, right?[00:17:20] That you like, you know, really good outcomes from a venture perspective that are effective acquihires, right? So I would say it's probably net positive from the investment standpoint, even though it seems from the headlines to be very disruptive in a negative way.[00:17:33] Alessio: Yeah.[00:17:33] What's Underfunded: Boring Software, Robotics Skepticism, and Custom Silicon Economics[00:17:33] Alessio: Um, let's talk maybe about what's not being invested in, like maybe some interesting ideas that you would see more people build or it, it seems in a way, you know, as ycs getting more popular, it's like access getting more popular.[00:17:47] There's a startup school path that a lot of founders take and they know what's hot in the VC circles and they know what gets funded. Uh, and there's maybe not as much risk appetite for. Things outside of that. Um, I'm curious if you feel [00:18:00] like that's true and what are maybe, uh, some of the areas, uh, that you think are under discussed?[00:18:06] Martin Casado: I mean, I actually think that we've taken our eye off the ball in a lot of like, just traditional, you know, software companies. Um, so like, I mean. You know, I think right now there's almost a barbell, like you're like the hot thing on X, you're deep tech.[00:18:21] swyx: Mm-hmm.[00:18:22] Martin Casado: Right. But I, you know, I feel like there's just kind of a long, you know, list of like good.[00:18:28] Good companies that will be around for a long time in very large markets. Say you're building a database, you know, say you're building, um, you know, kind of monitoring or logging or tooling or whatever. There's some good companies out there right now, but like, they have a really hard time getting, um, the attention of investors.[00:18:43] And it's almost become a meme, right? Which is like, if you're not basically growing from zero to a hundred in a year, you're not interesting, which is just, is the silliest thing to say. I mean, think of yourself as like an introvert person, like, like your personal money, right? Mm-hmm. So. Your personal money, will you put it in the stock market at 7% or you put it in this company growing five x in a very large [00:19:00] market?[00:19:00] Of course you can put it in the company five x. So it's just like we say these stupid things, like if you're not going from zero to a hundred, but like those, like who knows what the margins of those are mean. Clearly these are good investments. True for anybody, right? True. Like our LPs want whatever.[00:19:12] Three x net over, you know, the life cycle of a fund, right? So a, a company in a big market growing five X is a great investment. We'd, everybody would be happy with these returns, but we've got this kind of mania on these, these strong growths. And so I would say that that's probably the most underinvested sector.[00:19:28] Right now.[00:19:29] swyx: Boring software, boring enterprise software.[00:19:31] Martin Casado: Traditional. Really good company.[00:19:33] swyx: No, no AI here.[00:19:34] Martin Casado: No. Like boring. Well, well, the AI of course is pulling them into use cases. Yeah, but that's not what they're, they're not on the token path, right? Yeah. Let's just say that like they're software, but they're not on the token path.[00:19:41] Like these are like they're great investments from any definition except for like random VC on Twitter saying VC on x, saying like, it's not growing fast enough. What do you[00:19:52] Sarah Wang: think? Yeah, maybe I'll answer a slightly different. Question, but adjacent to what you asked, um, which is maybe an area that we're not, uh, investing [00:20:00] right now that I think is a question and we're spending a lot of time in regardless of whether we pull the trigger or not.[00:20:05] Um, and it would probably be on the hardware side, actually. Robotics, right? And the robotics side. Robotics. Right. Which is, it's, I don't wanna say that it's not getting funding ‘cause it's clearly, uh, it's, it's sort of non-consensus to almost not invest in robotics at this point. But, um, we spent a lot of time in that space and I think for us, we just haven't seen the chat GPT moment.[00:20:22] Happen on the hardware side. Um, and the funding going into it feels like it's already. Taking that for granted.[00:20:30] Martin Casado: Yeah. Yeah. But we also went through the drone, you know, um, there's a zip line right, right out there. What's that? Oh yeah, there's a zip line. Yeah. What the drone, what the av And like one of the takeaways is when it comes to hardware, um, most companies will end up verticalizing.[00:20:46] Like if you're. If you're investing in a robot company for an A for agriculture, you're investing in an ag company. ‘cause that's the competition and that's surprising. And that's supply chain. And if you're doing it for mining, that's mining. And so the ad team does a lot of that type of stuff ‘cause they actually set up to [00:21:00] diligence that type of work.[00:21:01] But for like horizontal technology investing, there's very little when it comes to robots just because it's so fit for, for purpose. And so we kinda like to look at software. Solutions or horizontal solutions like applied intuition. Clearly from the AV wave deep map, clearly from the AV wave, I would say scale AI was actually a horizontal one for That's fair, you know, for robotics early on.[00:21:23] And so that sort of thing we're very, very interested. But the actual like robot interacting with the world is probably better for different team. Agree.[00:21:30] Alessio: Yeah, I'm curious who these teams are supposed to be that invest in them. I feel like everybody's like, yeah, robotics, it's important and like people should invest in it.[00:21:38] But then when you look at like the numbers, like the capital requirements early on versus like the moment of, okay, this is actually gonna work. Let's keep investing. That seems really hard to predict in a way that is not,[00:21:49] Martin Casado: I think co, CO two, kla, gc, I mean these are all invested in in Harvard companies. He just, you know, and [00:22:00] listen, I mean, it could work this time for sure.[00:22:01] Right? I mean if Elon's doing it, he's like, right. Just, just the fact that Elon's doing it means that there's gonna be a lot of capital and a lot of attempts for a long period of time. So that alone maybe suggests that we should just be investing in robotics just ‘cause you have this North star who's Elon with a humanoid and that's gonna like basically willing into being an industry.[00:22:17] Um, but we've just historically found like. We're a huge believer that this is gonna happen. We just don't feel like we're in a good position to diligence these things. ‘cause again, robotics companies tend to be vertical. You really have to understand the market they're being sold into. Like that's like that competitive equilibrium with a human being is what's important.[00:22:34] It's not like the core tech and like we're kind of more horizontal core tech type investors. And this is Sarah and I. Yeah, the ad team is different. They can actually do these types of things.[00:22:42] swyx: Uh, just to clarify, AD stands for[00:22:44] Martin Casado: American Dynamism.[00:22:45] swyx: Alright. Okay. Yeah, yeah, yeah. Uh, I actually, I do have a related question that, first of all, I wanna acknowledge also just on the, on the chip side.[00:22:51] Yeah. I, I recall a podcast that where you were on, i, I, I think it was the a CC podcast, uh, about two or three years ago where you, where you suddenly said [00:23:00] something, which really stuck in my head about how at some point, at some point kind of scale it makes sense to. Build a custom aic Yes. For per run.[00:23:07] Martin Casado: Yes.[00:23:07] It's crazy. Yeah.[00:23:09] swyx: We're here and I think you, you estimated 500 billion, uh, something.[00:23:12] Martin Casado: No, no, no. A billion, a billion dollar training run of $1 billion training run. It makes sense to actually do a custom meic if you can do it in time. The question now is timelines. Yeah, but not money because just, just, just rough math.[00:23:22] If it's a billion dollar training. Then the inference for that model has to be over a billion, otherwise it won't be solvent. So let's assume it's, if you could save 20%, which you could save much more than that with an ASIC 20%, that's $200 million. You can tape out a chip for $200 million. Right? So now you can literally like justify economically, not timeline wise.[00:23:41] That's a different issue. An ASIC per model, which[00:23:44] swyx: is because that, that's how much we leave on the table every single time. We, we, we do like generic Nvidia.[00:23:48] Martin Casado: Exactly. Exactly. No, it, it is actually much more than that. You could probably get, you know, a factor of two, which would be 500 million.[00:23:54] swyx: Typical MFU would be like 50.[00:23:55] Yeah, yeah. And that's good.[00:23:57] Martin Casado: Exactly. Yeah. Hundred[00:23:57] swyx: percent. Um, so, so, yeah, and I mean, and I [00:24:00] just wanna acknowledge like, here we are in, in, in 2025 and opening eyes confirming like Broadcom and all the other like custom silicon deals, which is incredible. I, I think that, uh, you know, speaking about ad there's, there's a really like interesting tie in that obviously you guys are hit on, which is like these sort, this sort of like America first movement or like sort of re industrialized here.[00:24:17] Yeah. Uh, move TSMC here, if that's possible. Um, how much overlap is there from ad[00:24:23] Martin Casado: Yeah.[00:24:23] swyx: To, I guess, growth and, uh, investing in particularly like, you know, US AI companies that are strongly bounded by their compute.[00:24:32] Martin Casado: Yeah. Yeah. So I mean, I, I would view, I would view AD as more as a market segmentation than like a mission, right?[00:24:37] So the market segmentation is, it has kind of regulatory compliance issues or government, you know, sale or it deals with like hardware. I mean, they're just set up to, to, to, to, to. To diligence those types of companies. So it's a more of a market segmentation thing. I would say the entire firm. You know, which has been since it is been intercepted, you know, has geographical biases, right?[00:24:58] I mean, for the longest time we're like, you [00:25:00] know, bay Area is gonna be like, great, where the majority of the dollars go. Yeah. And, and listen, there, there's actually a lot of compounding effects for having a geographic bias. Right. You know, everybody's in the same place. You've got an ecosystem, you're there, you've got presence, you've got a network.[00:25:12] Um, and, uh, I mean, I would say the Bay area's very much back. You know, like I, I remember during pre COVID, like it was like almost Crypto had kind of. Pulled startups away. Miami from the Bay Area. Miami, yeah. Yeah. New York was, you know, because it's so close to finance, came up like Los Angeles had a moment ‘cause it was so close to consumer, but now it's kind of come back here.[00:25:29] And so I would say, you know, we tend to be very Bay area focused historically, even though of course we've asked all over the world. And then I would say like, if you take the ring out, you know, one more, it's gonna be the US of course, because we know it very well. And then one more is gonna be getting us and its allies and Yeah.[00:25:44] And it goes from there.[00:25:45] Sarah Wang: Yeah,[00:25:45] Martin Casado: sorry.[00:25:46] Sarah Wang: No, no. I agree. I think from a, but I think from the intern that that's sort of like where the companies are headquartered. Maybe your questions on supply chain and customer base. Uh, I, I would say our customers are, are, our companies are fairly international from that perspective.[00:25:59] Like they're selling [00:26:00] globally, right? They have global supply chains in some cases.[00:26:03] Martin Casado: I would say also the stickiness is very different.[00:26:05] Sarah Wang: Yeah.[00:26:05] Martin Casado: Historically between venture and growth, like there's so much company building in venture, so much so like hiring the next PM. Introducing the customer, like all of that stuff.[00:26:15] Like of course we're just gonna be stronger where we have our network and we've been doing business for 20 years. I've been in the Bay Area for 25 years, so clearly I'm just more effective here than I would be somewhere else. Um, where I think, I think for some of the later stage rounds, the companies don't need that much help.[00:26:30] They're already kind of pretty mature historically, so like they can kind of be everywhere. So there's kind of less of that stickiness. This is different in the AI time. I mean, Sarah is now the, uh, chief of staff of like half the AI companies in, uh, in the Bay Area right now. She's like, ops Ninja Biz, Devrel, BizOps.[00:26:48] swyx: Are, are you, are you finding much AI automation in your work? Like what, what is your stack.[00:26:53] Sarah Wang: Oh my, in my personal stack.[00:26:54] swyx: I mean, because like, uh, by the way, it's the, the, the reason for this is it is triggering, uh, yeah. We, like, I'm hiring [00:27:00] ops, ops people. Um, a lot of ponders I know are also hiring ops people and I'm just, you know, it's opportunity Since you're, you're also like basically helping out with ops with a lot of companies.[00:27:09] What are people doing these days? Because it's still very manual as far as I can tell.[00:27:13] Sarah Wang: Hmm. Yeah. I think the things that we help with are pretty network based, um, in that. It's sort of like, Hey, how do do I shortcut this process? Well, let's connect you to the right person. So there's not quite an AI workflow for that.[00:27:26] I will say as a growth investor, Claude Cowork is pretty interesting. Yeah. Like for the first time, you can actually get one shot data analysis. Right. Which, you know, if you're gonna do a customer database, analyze a cohort retention, right? That's just stuff that you had to do by hand before. And our team, the other, it was like midnight and the three of us were playing with Claude Cowork.[00:27:47] We gave it a raw file. Boom. Perfectly accurate. We checked the numbers. It was amazing. That was my like, aha moment. That sounds so boring. But you know, that's, that's the kind of thing that a growth investor is like, [00:28:00] you know, slaving away on late at night. Um, done in a few seconds.[00:28:03] swyx: Yeah. You gotta wonder what the whole, like, philanthropic labs, which is like their new sort of products studio.[00:28:10] Yeah. What would that be worth as an independent, uh, startup? You know, like a[00:28:14] Martin Casado: lot.[00:28:14] Sarah Wang: Yeah, true.[00:28:16] swyx: Yeah. You[00:28:16] Martin Casado: gotta hand it to them. They've been executing incredibly well.[00:28:19] swyx: Yeah. I, I mean, to me, like, you know, philanthropic, like building on cloud code, I think, uh, it makes sense to me the, the real. Um, pedal to the metal, whatever the, the, the phrase is, is when they start coming after consumer with, uh, against OpenAI and like that is like red alert at Open ai.[00:28:35] Oh, I[00:28:35] Martin Casado: think they've been pretty clear. They're enterprise focused.[00:28:37] swyx: They have been, but like they've been free. Here's[00:28:40] Martin Casado: care publicly,[00:28:40] swyx: it's enterprise focused. It's coding. Right. Yeah.[00:28:43] AI Labs vs Startups: Disruption, Undercutting & the Innovator's Dilemma[00:28:43] swyx: And then, and, but here's cloud, cloud, cowork, and, and here's like, well, we, uh, they, apparently they're running Instagram ads for Claudia.[00:28:50] I, on, you know, for, for people on, I get them all the time. Right. And so, like,[00:28:54] Martin Casado: uh,[00:28:54] swyx: it, it's kind of like this, the disruption thing of, uh, you know. Mo Open has been doing, [00:29:00] consumer been doing the, just pursuing general intelligence in every mo modality, and here's a topic that only focus on this thing, but now they're sort of undercutting and doing the whole innovator's dilemma thing on like everything else.[00:29:11] Martin Casado: It's very[00:29:11] swyx: interesting.[00:29:12] Martin Casado: Yeah, I mean there's, there's a very open que so for me there's like, do you know that meme where there's like the guy in the path and there's like a path this way? There's a path this way. Like one which way Western man. Yeah. Yeah.[00:29:23] Two Futures for AI: Infinite Market vs AGI Oligopoly[00:29:23] Martin Casado: And for me, like, like all the entire industry kind of like hinges on like two potential futures.[00:29:29] So in, in one potential future, um, the market is infinitely large. There's perverse economies of scale. ‘cause as soon as you put a model out there, like it kind of sublimates and all the other models catch up and like, it's just like software's being rewritten and fractured all over the place and there's tons of upside and it just grows.[00:29:48] And then there's another path which is like, well. Maybe these models actually generalize really well, and all you have to do is train them with three times more money. That's all you have to [00:30:00] do, and it'll just consume everything beyond it. And if that's the case, like you end up with basically an oligopoly for everything, like, you know mm-hmm.[00:30:06] Because they're perfectly general and like, so this would be like the, the a GI path would be like, these are perfectly general. They can do everything. And this one is like, this is actually normal software. The universe is complicated. You've got, and nobody knows the answer.[00:30:18] The Economics Reality Check: Gross Margins, Training Costs & Borrowing Against the Future[00:30:18] Martin Casado: My belief is if you actually look at the numbers of these companies, so generally if you look at the numbers of these companies, if you look at like the amount they're making and how much they, they spent training the last model, they're gross margin positive.[00:30:30] You're like, oh, that's really working. But if you look at like. The current training that they're doing for the next model, their gross margin negative. So part of me thinks that a lot of ‘em are kind of borrowing against the future and that's gonna have to slow down. It's gonna catch up to them at some point in time, but we don't really know.[00:30:47] Sarah Wang: Yeah.[00:30:47] Martin Casado: Does that make sense? Like, I mean, it could be, it could be the case that the only reason this is working is ‘cause they can raise that next round and they can train that next model. ‘cause these models have such a short. Life. And so at some point in time, like, you know, they won't be able to [00:31:00] raise that next round for the next model and then things will kind of converge and fragment again.[00:31:03] But right now it's not.[00:31:04] Sarah Wang: Totally. I think the other, by the way, just, um, a meta point. I think the other lesson from the last three years is, and we talk about this all the time ‘cause we're on this. Twitter X bubble. Um, cool. But, you know, if you go back to, let's say March, 2024, that period, it felt like a, I think an open source model with an, like a, you know, benchmark leading capability was sort of launching on a daily basis at that point.[00:31:27] And, um, and so that, you know, that's one period. Suddenly it's sort of like open source takes over the world. There's gonna be a plethora. It's not an oligopoly, you know, if you fast, you know, if you, if you rewind time even before that GPT-4 was number one for. Nine months, 10 months. It's a long time. Right.[00:31:44] Um, and of course now we're in this era where it feels like an oligopoly, um, maybe some very steady state shifts and, and you know, it could look like this in the future too, but it just, it's so hard to call. And I think the thing that keeps, you know, us up at [00:32:00] night in, in a good way and bad way, is that the capability progress is actually not slowing down.[00:32:06] And so until that happens, right, like you don't know what's gonna look like.[00:32:09] Martin Casado: But I, I would, I would say for sure it's not converged, like for sure, like the systemic capital flows have not converged, meaning right now it's still borrowing against the future to subsidize growth currently, which you can do that for a period of time.[00:32:23] But, but you know, at the end, at some point the market will rationalize that and just nobody knows what that will look like.[00:32:29] Alessio: Yeah.[00:32:29] Martin Casado: Or, or like the drop in price of compute will, will, will save them. Who knows?[00:32:34] Alessio: Yeah. Yeah. I think the models need to ask them to, to specific tasks. You know? It's like, okay, now Opus 4.5 might be a GI at some specific task, and now you can like depreciate the model over a longer time.[00:32:45] I think now, now, right now there's like no old model.[00:32:47] Martin Casado: No, but let, but lemme just change that mental, that's, that used to be my mental model. Lemme just change it a little bit.[00:32:53] Capital as a Weapon vs Task Saturation: Where Real Enterprise Value Gets Built[00:32:53] Martin Casado: If you can raise three times, if you can raise more than the aggregate of anybody that uses your models, that doesn't even matter.[00:32:59] It doesn't [00:33:00] even matter. See what I'm saying? Like, yeah. Yeah. So, so I have an API Business. My API business is 60% margin, or 70% margin, or 80% margin is a high margin business. So I know what everybody is using. If I can raise more money than the aggregate of everybody that's using it, I will consume them whether I'm a GI or not.[00:33:14] And I will know if they're using it ‘cause they're using it. And like, unlike in the past where engineering stops me from doing that.[00:33:21] Alessio: Mm-hmm.[00:33:21] Martin Casado: It is very straightforward. You just train. So I also thought it was kind of like, you must ask the code a GI, general, general, general. But I think there's also just a possibility that the, that the capital markets will just give them the, the, the ammunition to just go after everybody on top of ‘em.[00:33:36] Sarah Wang: I, I do wonder though, to your point, um, if there's a certain task that. Getting marginally better isn't actually that much better. Like we've asked them to it, to, you know, we can call it a GI or whatever, you know, actually, Ali Goi talks about this, like we're already at a GI for a lot of functions in the enterprise.[00:33:50] Um. That's probably those for those tasks, you probably could build very specific companies that focus on just getting as much value out of that task that isn't [00:34:00] coming from the model itself. There's probably a rich enterprise business to be built there. I mean, could be wrong on that, but there's a lot of interesting examples.[00:34:08] So, right, if you're looking the legal profession or, or whatnot, and maybe that's not a great one ‘cause the models are getting better on that front too, but just something where it's a bit saturated, then the value comes from. Services. It comes from implementation, right? It comes from all these things that actually make it useful to the end customer.[00:34:24] Martin Casado: Sorry, what am I, one more thing I think is, is underused in all of this is like, to what extent every task is a GI complete.[00:34:31] Sarah Wang: Mm-hmm.[00:34:32] Martin Casado: Yeah. I code every day. It's so fun.[00:34:35] Sarah Wang: That's a core question. Yeah.[00:34:36] Martin Casado: And like. When I'm talking to these models, it's not just code. I mean, it's everything, right? Like I, you know, like it's,[00:34:43] swyx: it's healthcare.[00:34:44] It's,[00:34:44] Martin Casado: I mean, it's[00:34:44] swyx: Mele,[00:34:45] Martin Casado: but it's every, it is exactly that. Like, yeah, that's[00:34:47] Sarah Wang: great support. Yeah.[00:34:48] Martin Casado: It's everything. Like I'm asking these models to, yeah, to understand compliance. I'm asking these models to go search the web. I'm asking these models to talk about things I know in the history, like it's having a full conversation with me while I, I engineer, and so it could be [00:35:00] the case that like, mm-hmm.[00:35:01] The most a, you know, a GI complete, like I'm not an a GI guy. Like I think that's, you know, but like the most a GI complete model will is win independent of the task. And we don't know the answer to that one either.[00:35:11] swyx: Yeah.[00:35:12] Martin Casado: But it seems to me that like, listen, codex in my experience is for sure better than Opus 4.5 for coding.[00:35:18] Like it finds the hardest bugs that I work in with. Like, it is, you know. The smartest developers. I don't work on it. It's great. Um, but I think Opus 4.5 is actually very, it's got a great bedside manner and it really, and it, it really matters if you're building something very complex because like, it really, you know, like you're, you're, you're a partner and a brainstorming partner for somebody.[00:35:38] And I think we don't discuss enough how every task kind of has that quality.[00:35:42] swyx: Mm-hmm.[00:35:43] Martin Casado: And what does that mean to like capital investment and like frontier models and Submodels? Yeah.[00:35:47] Why “Coding Models” Keep Collapsing into Generalists (Reasoning vs Taste)[00:35:47] Martin Casado: Like what happened to all the special coding models? Like, none of ‘em worked right. So[00:35:51] Alessio: some of them, they didn't even get released.[00:35:53] Magical[00:35:54] Martin Casado: Devrel. There's a whole, there's a whole host. We saw a bunch of them and like there's this whole theory that like, there could be, and [00:36:00] I think one of the conclusions is, is like there's no such thing as a coding model,[00:36:04] Alessio: you know?[00:36:04] Martin Casado: Like, that's not a thing. Like you're talking to another human being and it's, it's good at coding, but like it's gotta be good at everything.[00:36:10] swyx: Uh, minor disagree only because I, I'm pretty like, have pretty high confidence that basically open eye will always release a GPT five and a GT five codex. Like that's the code's. Yeah. The way I call it is one for raisin, one for Tiz. Um, and, and then like someone internal open, it was like, yeah, that's a good way to frame it.[00:36:32] Martin Casado: That's so funny.[00:36:33] swyx: Uh, but maybe it, maybe it collapses down to reason and that's it. It's not like a hundred dimensions doesn't life. Yeah. It's two dimensions. Yeah, yeah, yeah, yeah. Like and exactly. Beside manner versus coding. Yeah.[00:36:43] Martin Casado: Yeah.[00:36:44] swyx: It's, yeah.[00:36:46] Martin Casado: I, I think for, for any, it's hilarious. For any, for anybody listening to this for, for, for, I mean, for you, like when, when you're like coding or using these models for something like that.[00:36:52] Like actually just like be aware of how much of the interaction has nothing to do with coding and it just turns out to be a large portion of it. And so like, you're, I [00:37:00] think like, like the best Soto ish model. You know, it is going to remain very important no matter what the task is.[00:37:06] swyx: Yeah.[00:37:07] What He's Actually Coding: Gaussian Splats, Spark.js & 3D Scene Rendering Demos[00:37:07] swyx: Uh, speaking of coding, uh, I, I'm gonna be cheeky and ask like, what actually are you coding?[00:37:11] Because obviously you, you could code anything and you are obviously a busy investor and a manager of the good. Giant team. Um, what are you calling?[00:37:18] Martin Casado: I help, um, uh, FEFA at World Labs. Uh, it's one of the investments and um, and they're building a foundation model that creates 3D scenes.[00:37:27] swyx: Yeah, we had it on the pod.[00:37:28] Yeah. Yeah,[00:37:28] Martin Casado: yeah. And so these 3D scenes are Gaussian splats, just by the way that kind of AI works. And so like, you can reconstruct a scene better with, with, with radiance feels than with meshes. ‘cause like they don't really have topology. So, so they, they, they produce each. Beautiful, you know, 3D rendered scenes that are Gaussian splats, but the actual industry support for Gaussian splats isn't great.[00:37:50] It's just never, you know, it's always been meshes and like, things like unreal use meshes. And so I work on a open source library called Spark js, which is a. Uh, [00:38:00] a JavaScript rendering layer ready for Gaussian splats. And it's just because, you know, um, you, you, you need that support and, and right now there's kind of a three js moment that's all meshes and so like, it's become kind of the default in three Js ecosystem.[00:38:13] As part of that to kind of exercise the library, I just build a whole bunch of cool demos. So if you see me on X, you see like all my demos and all the world building, but all of that is just to exercise this, this library that I work on. ‘cause it's actually a very tough algorithmics problem to actually scale a library that much.[00:38:29] And just so you know, this is ancient history now, but 30 years ago I paid for undergrad, you know, working on game engines in college in the late nineties. So I've got actually a back and it's very old background, but I actually have a background in this and so a lot of it's fun. You know, but, but the, the, the, the whole goal is just for this rendering library to, to,[00:38:47] Sarah Wang: are you one of the most active contributors?[00:38:49] The, their GitHub[00:38:50] Martin Casado: spark? Yes.[00:38:51] Sarah Wang: Yeah, yeah.[00:38:51] Martin Casado: There's only two of us there, so, yes. No, so by the way, so the, the pri The pri, yeah. Yeah. So the primary developer is a [00:39:00] guy named Andres Quist, who's an absolute genius. He and I did our, our PhDs together. And so like, um, we studied for constant Quas together. It was almost like hanging out with an old friend, you know?[00:39:09] And so like. So he, he's the core, core guy. I did mostly kind of, you know, the side I run venture fund.[00:39:14] swyx: It's amazing. Like five years ago you would not have done any of this. And it brought you back[00:39:19] Martin Casado: the act, the Activ energy, you're still back. Energy was so high because you had to learn all the framework b******t.[00:39:23] Man, I f*****g used to hate that. And so like, now I don't have to deal with that. I can like focus on the algorithmics so I can focus on the scaling and I,[00:39:29] swyx: yeah. Yeah.[00:39:29] LLMs vs Spatial Intelligence + How to Value World Labs' 3D Foundation Model[00:39:29] swyx: And then, uh, I'll observe one irony and then I'll ask a serious investor question, uh, which is like, the irony is FFE actually doesn't believe that LMS can lead us to spatial intelligence.[00:39:37] And here you are using LMS to like help like achieve spatial intelligence. I just see, I see some like disconnect in there.[00:39:45] Martin Casado: Yeah. Yeah. So I think, I think, you know, I think, I think what she would say is LLMs are great to help with coding.[00:39:51] swyx: Yes.[00:39:51] Martin Casado: But like, that's very different than a model that actually like provides, they, they'll never have the[00:39:56] swyx: spatial inte[00:39:56] Martin Casado: issues.[00:39:56] And listen, our brains clearly listen, our brains, brains clearly have [00:40:00] both our, our brains clearly have a language reasoning section and they clearly have a spatial reasoning section. I mean, it's just, you know, these are two pretty independent problems.[00:40:07] swyx: Okay. And you, you, like, I, I would say that the, the one data point I recently had, uh, against it is the DeepMind, uh, IMO Gold, where, so, uh, typically the, the typical answer is that this is where you start going down the neuros symbolic path, right?[00:40:21] Like one, uh, sort of very sort of abstract reasoning thing and one form, formal thing. Um, and that's what. DeepMind had in 2024 with alpha proof, alpha geometry, and now they just use deep think and just extended thinking tokens. And it's one model and it's, and it's in LM.[00:40:36] Martin Casado: Yeah, yeah, yeah, yeah, yeah.[00:40:37] swyx: And so that, that was my indication of like, maybe you don't need a separate system.[00:40:42] Martin Casado: Yeah. So, so let me step back. I mean, at the end of the day, at the end of the day, these things are like nodes in a graph with weights on them. Right. You know, like it can be modeled like if you, if you distill it down. But let me just talk about the two different substrates. Let's, let me put you in a dark room.[00:40:56] Like totally black room. And then let me just [00:41:00] describe how you exit it. Like to your left, there's a table like duck below this thing, right? I mean like the chances that you're gonna like not run into something are very low. Now let me like turn on the light and you actually see, and you can do distance and you know how far something away is and like where it is or whatever.[00:41:17] Then you can do it, right? Like language is not the right primitives to describe. The universe because it's not exact enough. So that's all Faye, Faye is talking about. When it comes to like spatial reasoning, it's like you actually have to know that this is three feet far, like that far away. It is curved.[00:41:37] You have to understand, you know, the, like the actual movement through space.[00:41:40] swyx: Yeah.[00:41:40] Martin Casado: So I do, I listen, I do think at the end of these models are definitely converging as far as models, but there's, there's, there's different representations of problems you're solving. One is language. Which, you know, that would be like describing to somebody like what to do.[00:41:51] And the other one is actually just showing them and the space reasoning is just showing them.[00:41:55] swyx: Yeah, yeah, yeah. Right. Got it, got it. Uh, the, in the investor question was on, on, well labs [00:42:00] is, well, like, how do I value something like this? What, what, what work does the, do you do? I'm just like, Fefe is awesome.[00:42:07] Justin's awesome. And you know, the other two co-founder, co-founders, but like the, the, the tech, everyone's building cool tech. But like, what's the value of the tech? And this is the fundamental question[00:42:16] Martin Casado: of, well, let, let, just like these, let me just maybe give you a rough sketch on the diffusion models. I actually love to hear Sarah because I'm a venture for, you know, so like, ventures always, always like kind of wild west type[00:42:24] swyx: stuff.[00:42:24] You, you, you, you paid a dream and she has to like, actually[00:42:28] Martin Casado: I'm gonna say I'm gonna mar to reality, so I'm gonna say the venture for you. And she can be like, okay, you a little kid. Yeah. So like, so, so these diffusion models literally. Create something for, for almost nothing. And something that the, the world has found to be very valuable in the past, in our real markets, right?[00:42:45] Like, like a 2D image. I mean, that's been an entire market. People value them. It takes a human being a long time to create it, right? I mean, to create a, you know, a, to turn me into a whatever, like an image would cost a hundred bucks in an hour. The inference cost [00:43:00] us a hundredth of a penny, right? So we've seen this with speech in very successful companies.[00:43:03] We've seen this with 2D image. We've seen this with movies. Right? Now, think about 3D scene. I mean, I mean, when's Grand Theft Auto coming out? It's been six, what? It's been 10 years. I mean, how, how like, but hasn't been 10 years.[00:43:14] Alessio: Yeah.[00:43:15] Martin Casado: How much would it cost to like, to reproduce this room in 3D? Right. If you, if you, if you hired somebody on fiber, like in, in any sort of quality, probably 4,000 to $10,000.[00:43:24] And then if you had a professional, probably $30,000. So if you could generate the exact same thing from a 2D image, and we know that these are used and they're using Unreal and they're using Blend, or they're using movies and they're using video games and they're using all. So if you could do that for.[00:43:36] You know, less than a dollar, that's four or five orders of magnitude cheaper. So you're bringing the marginal cost of something that's useful down by three orders of magnitude, which historically have created very large companies. So that would be like the venture kind of strategic dreaming map.[00:43:49] swyx: Yeah.[00:43:50] And, and for listeners, uh, you can do this yourself on your, on your own phone with like. Uh, the marble.[00:43:55] Martin Casado: Yeah. Marble.[00:43:55] swyx: Uh, or but also there's many Nerf apps where you just go on your iPhone and, and do this.[00:43:59] Martin Casado: Yeah. Yeah. [00:44:00] Yeah. And, and in the case of marble though, it would, what you do is you literally give it in.[00:44:03] So most Nerf apps you like kind of run around and take a whole bunch of pictures and then you kind of reconstruct it.[00:44:08] swyx: Yeah.[00:44:08] Martin Casado: Um, things like marble, just that the whole generative 3D space will just take a 2D image and it'll reconstruct all the like, like[00:44:16] swyx: meaning it has to fill in. Uh,[00:44:18] Martin Casado: stuff at the back of the table, under the table, the back, like, like the images, it doesn't see.[00:44:22] So the generator stuff is very different than reconstruction that it fills in the things that you can't see.[00:44:26] swyx: Yeah. Okay.[00:44:26] Sarah Wang: So,[00:44:27] Martin Casado: all right. So now the,[00:44:28] Sarah Wang: no, no. I mean I love that[00:44:29] Martin Casado: the adult[00:44:29] Sarah Wang: perspective. Um, well, no, I was gonna say these are very much a tag team. So we, we started this pod with that, um, premise. And I think this is a perfect question to even build on that further.[00:44:36] ‘cause it truly is, I mean, we're tag teaming all of these together.[00:44:39] Investing in Model Labs, Media Rumors, and the Cursor Playbook (Margins & Going Down-Stack)[00:44:39] Sarah Wang: Um, but I think every investment fundamentally starts with the same. Maybe the same two premises. One is, at this point in time, we actually believe that there are. And of one founders for their particular craft, and they have to be demonstrated in their prior careers, right?[00:44:56] So, uh, we're not investing in every, you know, now the term is NEO [00:45:00] lab, but every foundation model, uh, any, any company, any founder trying to build a foundation model, we're not, um, contrary to popular opinion, we're

Self Created Valuation Boosts Apple Announces new Podcast push AI – A breakdown Playing them like a fiddle – Warner Brothers PLUS we are now on Spotify and Amazon Music/Podcasts! Click HERE for Show Notes and Links DHUnplugged is now streaming live - with listener chat. Click on link on the right sidebar. Love the Show? Then how about a Donation? Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter Warm-Up - A NEW CTP just announced - China releasing new AI models - AI - A breakdown - we are on overload - Big Employment news.... Markets - Self Created Valuation Boosts - Apple Announces new Podcast push - Playing them like a fiddle - Warner Brothers Quick Note - Going to rip up the playbook on something this week on TDI Podcast. Anyone who owns an annuity should listen to what is about to come on next Sundays show.....  No Agenda... Olympics - Anything to discuss? MONEY FOR ALL - The average tax refund is 10.9% higher so far this season, compared to about the same point in 2025, according to early filing data from the IRS. - The 2026 tax season opened Jan. 26, and the average refund amount was $2,290 as of Feb. 6, up from $2,065 about one year prior, the IRS reported Friday night. - As of Feb. 6, the total amount refunded was more than $16.9 billion, up 1.9% compared to last year, according to the IRS release. That figure reflects current-year returns only. - This is partly because there were excess-witholdings from last year on the rules changed and paycheck withholdings were not adjusted. This is a one time situation.. Emplyment - 4.3% - "Better" than expected payrolls number - A major revision was released last Wednesday. Overall 2025 job growth was much weaker than initially reported. The total net change for the full year 2025 was revised down from +584,000 jobs to just +181,000 jobs (seasonally adjusted) — an average of only about 15,000 jobs added per month instead of ~49,000. This made 2025 one of the weakest years for job creation in recent non-recession periods. - Employment levels were consistently overstated throughout 2025 by roughly 800,000 to over 1 million jobs, peaking around mid-year. For example: By March 2025, the level was revised down by 898,000. By December 2025 (preliminary), down by 1,029,000. - Monthly changes were also adjusted downward in most cases (e.g., August's originally reported -26,000 became a larger loss of -70,000; September's +108,000 became +76,000). - The revisions reflect normal annual benchmarking, but this one was unusually large (larger than the typical 0.2% average over the prior decade), likely due to factors like overestimation of business births or other data mismatches. - In short, the data reveals that the U.S. labor market in 2025 was significantly softer than the monthly headlines suggested at the time — job growth was overstated by a substantial margin, painting a picture of a much weaker employment picture for the year. AI Updates - While U.S. markets have been focused on the impact of Anthropic and Altruist's tools on software and financial services, China's tech giants have released AI models this week that have shown advancements in robotics and video generation. - Google is reporting that China's AI models are just MONTHS behind western models - However - is this progress? In a video demo, Alibaba showed a robot with pincers for hands that appeared to be able to count oranges, pick them up and place them in a basket. It was also shown taking milk out of a fridge. - Alibaba on Monday unveiled a new artificial intelligence model Qwen 3.5 designed to execute complex tasks independently, with big improvements in performance and cost that the Chinese tech giant claims beat major U.S. rival models on several benchmarks. - Zhipu AI — which trades as Knowledge Atlas Technology in Hong Kong said the model approaches Anthropic's Claude Opus 4.5 in coding benchmarks while surpassing Google's Gemini 3 Pro on some tests. - Shares of MiniMax also jumped Thursday after it launched its updated M2.5 open-source model with enhanced AI agent tools. Grok Update - Grok, Elon Musk's AI chatbot, has been gaining ground in the U.S. over the past months, data showed, even as it draws global censure and regulatory scrutiny after being used to generate a wave of non-consensual sexualized images of women and minors. - U.S. market share of the tool rose to 17.8% last month from 14% in December, and 1.9% in January 2025, according to data from research firm Apptopia. - Men are still the largest % users of Grok ~ 78% (down from 89% in April 2025) AI Market Share - ChatGPT's share slumped to 52.9% last month from 80.9% in January last year, while Gemini's grew to 29.4% from 17.3% over the same period. AI Market Share InfoGrapic and AI Understanding - Have we gone through this? - At its core, AI is technology that lets machines perform tasks that normally require human intelligence — things like understanding language, recognizing images, making decisions, or solving problems. - Modern AI (especially since ~2022) is dominated by machine learning — systems that learn patterns from huge amounts of data instead of being explicitly programmed rule-by-rule. - Inference is the "using" or "applying" phase of AI — when a trained model takes new input and produces an output / prediction / answer. Contrast with training (the "learning" phase): ------ Training ? Like a student studying for years: very compute-heavy, expensive, done once (or rarely) on massive servers/GPUs, adjusts billions of parameters based on examples. ------ Inference ? Like the student taking a test or doing their job: much faster, cheaper, runs on your phone/laptop/cloud, uses the fixed knowledge from training to respond instantly. - gentic AI takes regular AI (like chat models) to the next level: instead of just answering questions or generating text, these systems act autonomously to achieve goals with minimal human help. "Agentic" comes from "agency" — the ability to make decisions, plan, use tools, take actions, adapt, and even learn from results — like a smart digital employee rather than just a smart answer machine. AI Infographic Last AI Item - A shortage of memory chips is hammering profits, derailing corporate plans, and inflating price tags on various products, with the crunch expected to get worse. - The fundamental reason for the squeeze is the buildout of AI data centers, with companies like Alphabet and OpenAI buying up large shares of memory chip production, leaving consumer electronics producers fighting over a dwindling supply. - The resulting price spikes are causing concern, with some warning of "RAMmageddon" and others predicting that memory chip prices will go "parabolic", bringing lavish profits to some companies but painful prices to the rest of the electronics sector. Here is something: - Gallup will no longer track presidential approval ratings after nearly 90 years - Founded by George Gallup in 1935, the Washington, DC-based management company began tracking the president's job performance 88 years ago. - Gallup told USA TODAY it will no longer publish "favorability ratings of political figures," a decision it said "reflects an evolution in how Gallup focuses its public research and thought leadership." - Gallup said the ratings are now "widely produced, aggregated and interpreted, and no longer represent an area where Gallup can make its most distinctive contribution." - "Our commitment is to long-term, methodologically sound research on issues and conditions that shape people's lives," the company wrote, adding that its work will continue through the Gallup Poll Social Series, the Gallup Quarterly Business Review, the World Poll and more. - Seems like they are unable to SHAPE opinion due to social media etc.....? Apple Podcast Update - Big news! - Apple on Monday announced that it will bring a new integrated video podcast experience to Apple Podcasts this spring. - The move comes as video viewership continues to reshape podcasting. About 37% of people over age 12 watch video podcasts monthly, according to Edison Research. - The update brings Apple Podcasts more in-line with its competitors Spotify, YouTube and now Netflix, which have increasingly leaned into video podcasting. -“Twenty years ago, Apple helped take podcasting mainstream by adding podcasts to iTunes, and more than a decade ago, we introduced the dedicated Apple Podcasts app,” said Eddy Cue, Apple's senior vice president of Services, in a statement. “ - By bringing a category-leading video experience to Apple Podcasts, we're putting creators in full control of their content and how they build their businesses, while making it easier than ever for audiences to listen to or watch podcasts.” M&A - Texas Instruments Inc. has reached an agreement to buy Silicon Laboratories Inc. for about $7.5 billion, deepening its exposure to several markets for chips. - Silicon Labs investors will receive $231 in cash for each share of the company's common stock and the transaction is expected to close in the first half of 2027. - The transaction still needs to win approval by investors in Silicon Labs and shares of Silicon Labs surged by 51% to $206.48 after the announcement. Inflation - This helps - PepsiCo, will cut prices on core brands such as Lay's and Doritos by up to 15% following a consumer backlash against several previous price hikes, the snacks and beverage maker said on Tuesday after it topped fourth-quarter results. Miran - Moving - Federal Reserve Governor Stephen Miran is leaving his post as chair of the Council of Economic Advisers, CNBC has confirmed. - He joined the CEA in January 2025, but had been on leave from that post since last September when he filled the unexpired term of former Fed Governor Adriana Kugler.- He reamins on Fed board No Biggie???? - There are some astonishing cased being reported of Bad AI in the operating room - JNJ's TruDi Navigation System - Since AI was added to the device, the FDA has received unconfirmed reports of at least 100 malfunctions and adverse events. - At least 10 people were injured between late 2021 and November 2025, according to the reports. Most allegedly involved errors in which the TruDi Navigation System misinformed surgeons about the location of their instruments while they were using them inside patients' heads during operations. - Cerebrospinal fluid reportedly leaked from one patient's nose. In another reported case, a surgeon mistakenly punctured the base of a patient's skull. In two other cases, patients each allegedly suffered strokes after a major artery was accidentally injured. Cuba - The main airport has putt out a bulletin that they are out of Jet Fuel - Blackouts and lack of other fuels are creating big problems - No airlines have stopped running at this point, but many will as they cannot refuel - This is a bigger problem for cargo planes (supplies) that may not be able to risk flying to Cuba as they will not be able to get out. Dalio Warning -  Legendary investor Ray Dalio said on Tuesday the world was “on the brink” of a capital war. - He said central banks and sovereign wealth funds were already preparing for measures like foreign exchange and capital controls. - "When money is weaponized using measures like trade embargoes, blocking access to capital markets, or using ownership of debt as leverage." - “Capital, money, matters,” Dalio said Tuesday. “We're seeing capital controls … taking place all over the world today, and who will experience that is questionable. So, we are on the brink — that doesn't mean we are in [a capital war now], but it means that it's a logical concern.” - Could this be why gold and siver are being hoarded (physical assets over digital currency? - Is China's edict to banks to diversify away from US Treasuries a sign? Self Boosted Valuation - Waymo is aiming to raise about $16 billion in a financing-round that would value it at nearly $110 billion, Bloomberg News reported, citing people familiar with the matter. - Alphabet would provide about $13 billion to the autonomous driving firm while the rest would come from investors including Sequoia Capital, DST Global and Dragoneer Investment Group, the report added. - Soooooo - Waymo is a unit of Alphabet.... Alphabet providing 80% of the funding that boosts valuations..... Hmmmmmmmm Warner Brothers -  Warner Bros Discovery Inc is considering reopening sale talks with Paramount Skydance Corp after receiving its amended offer. - The Warner Bros board is discussing whether Paramount could offer a path to a superior deal, which may ignite a second bidding war with Netflix Inc. - Paramount submitted amended terms that addressed several concerns, including covering a fee owed to Netflix and offering to backstop a Warner Bros debt refinancing. Economics Coming Up - Short Week - plenty of Reports - Wednesday - Durable Goods, Housing Starts, Industrial Production, FOMC Minutes - Thursday - Philly Fed, Initial Claims - Friday: PCE, Personal Income and Spending, GDP for Q4 (3.6%) ----- New Home Sales, UMich Feb Final   Love the Show? Then how about a Donation? ANNOUNCING THE THE CLOSEST TO THE PIN for CATERPILLAR Winners will be getting great stuff like the new "OFFICIAL" DHUnplugged Shirt!     FED AND CRYPTO LIMERICKS   See this week's stock picks HERE Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter

Western Digital says most of its hard drives are SOLD OUT for 2026, joining RAM and GPUs as consumer products that are too expensive for consumers thanks to the AI boom. So no, you probably don't want to build that new gaming rig in 2026.Watch the podcast episodes on YouTube and all major podcast hosts including Spotify.CLOWNFISH TV is an independent, opinionated news and commentary podcast that covers Entertainment and Tech from a consumer's point of view. We talk about Gaming, Comics, Anime, TV, Movies, Animation and more. Hosted by Kneon and Geeky Sparkles.Get more news, views and reviews on Clownfish TV News - https://more.clownfishtv.com/On YouTube - https://www.youtube.com/c/ClownfishTVOn Spotify - https://open.spotify.com/show/4Tu83D1NcCmh7K1zHIedvgOn Apple Podcasts - https://podcasts.apple.com/us/podcast/clownfish-tv-audio-edition/id1726838629

Is traditional performance testing becoming obsolete? In this episode, performance engineering expert Akash Thakur shares why AI is fundamentally transforming load testing, scripting, observability, and shift-left strategies. With 17 years of real-world enterprise experience, Akash explains how AI-augmented tools are already reducing scripting time by 30%, improving analysis speed, and helping teams move from reactive performance testing to predictive intelligence. You'll learn: How AI is accelerating performance scripting and analysis Why shift-left performance testing is finally becoming realistic The role of structured data in predictive QA models How to test AI applications (LLMs, GPUs, inference throughput) differently than traditional web apps What the future role of performance engineers looks like — architect, not script writer If you're a performance tester, SRE, QA leader, or DevOps engineer wondering how AI will impact your role — this episode gives you practical, actionable insights you can apply immediately.

When we talk about the cost of AI infrastructure, the focus is usually on Nvidia and GPUs -- but memory is an increasingly important part of the picture. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Common Denominator, I break down one of the most extraordinary leadership stories of our time: Jensen Huang and NVIDIA.Over the last 36 months, NVIDIA has added roughly $100 billion in market cap per month, growing from a $300 billion company to nearly $4.5 trillion. But numbers like that don't happen by accident. They're the result of leadership.In this episode, I explore what kind of leadership it actually takes to build a company like NVIDIA — and what we can all learn from Jensen Huang's 32-year tenure as CEO.Here's what I dive into:- Why leadership compounds over time- The power of thinking in decades, not quarters- Why betting early on AI, GPUs, and CUDA looked irrational — but wasn't- How staying technically fluent at scale protects standards and speed- Why calm is one of the most underrated leadership traits- The difference between managing outcomes and managing direction- How great companies become infrastructure the world can't function withoutOn Common Denominator, I always ask: what's the real force behind extraordinary outcomes? More often than not, it's leadership. Not the title — the substance.Whether you're building a startup, leading a team, investing, or simply trying to lead yourself better, the lessons are the same:Think longer.Stay close to the work.Build for where the world is going.Don't let success dilute conviction.Jensen Huang didn't just build NVIDIA. He demonstrated what leadership looks like in an era of exponential change.And to me, that's the real common denominator.Like this episode? Leave a review here:https://ratethispodcast.com/commondenominator

This week's podcast is about the big release of Seedance 2.0 by Bytedance.You can listen to this podcast here, which has the slides and graphics mentioned. Also available at iTunes and Google Podcasts.Here is the link to the TechMoat Consulting.Here is the link to our Tech Tours.Here are some videos I made (here).Here are the winners:Viewers. It's amazing. GPUs and data centers. Plus energy providers. IP holders that get lots of attention.   Independent creators who will get lots attention and creative satisfaction. Business content creators - especially in ads and content. Platform biz models. Audience builders like YouTube and TikTok. Plus marketplaces like Taobao.iQiyi and combinations of streaming and audience builders.Netflix and pure streamers (maybe). Here are the losers:Most professional production companies. Most tv and film studios. Basically, any business that has been relying on scale in content creation. Ad agencies focused on content creation.Individuals and firms with specialized skills related to tv and film production.Independent content creators trying to monetize Los Angeles?Hollywood's managerial class. Political activists embedded in entertainment.Here are my past articles / podcasts on this:Why ChatGPT and Generative AI Are a Mortal Threat to Disney, Netflix and Most Hollywood Studios (Tech Strategy – Podcast 150)How Generative AI Is Going to Disrupt YouTube and TikTok (Tech Strategy – Podcast 152). Jan 2023How Generative AI Services Are Disrupting Platform Business Models (1 of 2) (Tech Strategy – Daily Article)-------I am a consultant and keynote speaker on how to increase digital growth and strengthen digital AI moats.I am the founder of TechMoat Consulting, a consulting firm specialized in how to increase digital growth and strengthen digital AI moats. Get in touch here.I write about digital growth and digital AI strategy. With 3 best selling books and +2.9M followers on LinkedIn. You can read my writing at the free email below.Note: This content (articles, podcasts, website info) is not investment advice. The information and opinions from me and any guests may be incorrect. The numbers and information may be wrong. The views expressed may no longer be relevant or accurate. Investing is rSupport the show

Welcome to Exponential View, the show where I explore how exponential technologies such as AI are reshaping our future. I've been studying AI and exponential technologies at the frontier for over ten years. Each week, I share some of my analysis or speak with an expert guest to make light of a particular topic. To keep up with the Exponential transition, subscribe to this channel or to my newsletter: https://www.exponentialview.co/ ----In this episode, I'm joined by Jaime Sevilla, founder of Epoch AI; Hannah Petrovic from my team at Exponential View; and financial journalist Matt Robinson from AI Street. Together we investigate a fundamental question: do the economics of AI companies actually work? We analysed OpenAI's financials from public data to examine whether their revenues can sustain the staggering R&D costs of frontier models. The findings reveal a picture far more precarious than many assume; we also explore where the real infrastructure bottlenecks lie, why compute demand will dwarf energy constraints, and what the rise of long-running agentic workloads means for the entire industry. Read the study here: https://www.exponentialview.co/p/inside-openais-unit-economics-epoch-exponentialviewWe covered: (00:00) Do the economics of frontier AI actually work? (02:48) Piecing together OpenAI's finances from public data (05:24) GPT-5's "rapidly depreciating asset" problem (13:25) Why OpenAI is flirting with ads (17:31) If you were Sam Altman, what would you do differently? (22:54) Energy vs. GPUs; where the real infrastructure bottleneck lies (29:15) What surging compute demand actually looks like (33:12) The most surprising finding from the research (38:02) The race to avoid commoditization (43:35) Agents that outlive their models  Where to find me: Exponential View newsletter: https://www.exponentialview.co/ Website: https://www.azeemazhar.com/ LinkedIn: https://www.linkedin.com/in/azhar/ Twitter/X: https://x.com/azeem  Where to find Jamie: https://epoch.ai or https://epochai.substack.com Where to find Matt: https://www.ai-street.co  Production by supermix.io and EPIIPLUS1 Production and research: Chantal Smith and Marija Gavrilov. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

“I think that for geophysicists out there, people need to realize that it's an integrated career path. You can't separate the geophysics from the HPC anymore, if we ever did to begin with.” High-performance computing is becoming more important as seismic data grows in size and complexity. This episode highlights the January The Leading Edge special section on high-performance computing. Guest editors Madhav Vyas and Elizabeth L'Heureux share their perspective on GPUs, CPUs, AI tools, and better algorithms in geophysics, and they stress that future success depends on combining geophysical knowledge with strong computational skills. KEY TAKEAWAYS > Modern seismic imaging depends on both advanced physics and powerful, well-chosen computing hardware. > Data movement and system architecture can limit performance as much as raw processing speed. > Geophysicists increasingly need programming and computational science skills alongside domain expertise. LINKS * Read the January 2026 special section, High-performance computing in geophysics - https://pubs.geoscienceworld.org/tle/issue/45/1 * Introduction to this special section: High-performance computing in geophysics by Madhav Vyas; Elizabeth L'Heureux; Raj Gautam - https://doi.org/10.1190/tle-4501-SS01 ABOUT SEISMIC SOUNDOFF Seismic Soundoff showcases conversations addressing the challenges of energy, water, and climate. Produced by the Society of Exploration Geophysicists (SEG) and hosted by Andrew Geary of 51 features, these episodes celebrate and inspire the geophysicists of today and tomorrow. Three new episodes monthly. See the full archive at https://seg.org/resources/podcast/.

This podcast features Gabriele Corso and Jeremy Wohlwend, co-founders of Boltz and authors of the Boltz Manifesto, discussing the rapid evolution of structural biology models from AlphaFold to their own open-source suite, Boltz-1 and Boltz-2. The central thesis is that while single-chain protein structure prediction is largely “solved” through evolutionary hints, the next frontier lies in modeling complex interactions (protein-ligand, protein-protein) and generative protein design, which Boltz aims to democratize via open-source foundations and scalable infrastructure.Full Video PodOn YouTube!Timestamps* 00:00 Introduction to Benchmarking and the “Solved” Protein Problem* 06:48 Evolutionary Hints and Co-evolution in Structure Prediction* 10:00 The Importance of Protein Function and Disease States* 15:31 Transitioning from AlphaFold 2 to AlphaFold 3 Capabilities* 19:48 Generative Modeling vs. Regression in Structural Biology* 25:00 The “Bitter Lesson” and Specialized AI Architectures* 29:14 Development Anecdotes: Training Boltz-1 on a Budget* 32:00 Validation Strategies and the Protein Data Bank (PDB)* 37:26 The Mission of Boltz: Democratizing Access and Open Source* 41:43 Building a Self-Sustaining Research Community* 44:40 Boltz-2 Advancements: Affinity Prediction and Design* 51:03 BoltzGen: Merging Structure and Sequence Prediction* 55:18 Large-Scale Wet Lab Validation Results* 01:02:44 Boltz Lab Product Launch: Agents and Infrastructure* 01:13:06 Future Directions: Developpability and the “Virtual Cell”* 01:17:35 Interacting with Skeptical Medicinal ChemistsKey SummaryEvolution of Structure Prediction & Evolutionary Hints* Co-evolutionary Landscapes: The speakers explain that breakthrough progress in single-chain protein prediction relied on decoding evolutionary correlations where mutations in one position necessitate mutations in another to conserve 3D structure.* Structure vs. Folding: They differentiate between structure prediction (getting the final answer) and folding (the kinetic process of reaching that state), noting that the field is still quite poor at modeling the latter.* Physics vs. Statistics: RJ posits that while models use evolutionary statistics to find the right “valley” in the energy landscape, they likely possess a “light understanding” of physics to refine the local minimum.The Shift to Generative Architectures* Generative Modeling: A key leap in AlphaFold 3 and Boltz-1 was moving from regression (predicting one static coordinate) to a generative diffusion approach that samples from a posterior distribution.* Handling Uncertainty: This shift allows models to represent multiple conformational states and avoid the “averaging” effect seen in regression models when the ground truth is ambiguous.* Specialized Architectures: Despite the “bitter lesson” of general-purpose transformers, the speakers argue that equivariant architectures remain vastly superior for biological data due to the inherent 3D geometric constraints of molecules.Boltz-2 and Generative Protein Design* Unified Encoding: Boltz-2 (and BoltzGen) treats structure and sequence prediction as a single task by encoding amino acid identities into the atomic composition of the predicted structure.* Design Specifics: Instead of a sequence, users feed the model blank tokens and a high-level “spec” (e.g., an antibody framework), and the model decodes both the 3D structure and the corresponding amino acids.* Affinity Prediction: While model confidence is a common metric, Boltz-2 focuses on affinity prediction—quantifying exactly how tightly a designed binder will stick to its target.Real-World Validation and Productization* Generalized Validation: To prove the model isn't just “regurgitating” known data, Boltz tested its designs on 9 targets with zero known interactions in the PDB, achieving nanomolar binders for two-thirds of them.* Boltz Lab Infrastructure: The newly launched Boltz Lab platform provides “agents” for protein and small molecule design, optimized to run 10x faster than open-source versions through proprietary GPU kernels.* Human-in-the-Loop: The platform is designed to convert skeptical medicinal chemists by allowing them to run parallel screens and use their intuition to filter model outputs.TranscriptRJ [00:05:35]: But the goal remains to, like, you know, really challenge the models, like, how well do these models generalize? And, you know, we've seen in some of the latest CASP competitions, like, while we've become really, really good at proteins, especially monomeric proteins, you know, other modalities still remain pretty difficult. So it's really essential, you know, in the field that there are, like, these efforts to gather, you know, benchmarks that are challenging. So it keeps us in line, you know, about what the models can do or not.Gabriel [00:06:26]: Yeah, it's interesting you say that, like, in some sense, CASP, you know, at CASP 14, a problem was solved and, like, pretty comprehensively, right? But at the same time, it was really only the beginning. So you can say, like, what was the specific problem you would argue was solved? And then, like, you know, what is remaining, which is probably quite open.RJ [00:06:48]: I think we'll steer away from the term solved, because we have many friends in the community who get pretty upset at that word. And I think, you know, fairly so. But the problem that was, you know, that a lot of progress was made on was the ability to predict the structure of single chain proteins. So proteins can, like, be composed of many chains. And single chain proteins are, you know, just a single sequence of amino acids. And one of the reasons that we've been able to make such progress is also because we take a lot of hints from evolution. So the way the models work is that, you know, they sort of decode a lot of hints. That comes from evolutionary landscapes. So if you have, like, you know, some protein in an animal, and you go find the similar protein across, like, you know, different organisms, you might find different mutations in them. And as it turns out, if you take a lot of the sequences together, and you analyze them, you see that some positions in the sequence tend to evolve at the same time as other positions in the sequence, sort of this, like, correlation between different positions. And it turns out that that is typically a hint that these two positions are close in three dimension. So part of the, you know, part of the breakthrough has been, like, our ability to also decode that very, very effectively. But what it implies also is that in absence of that co-evolutionary landscape, the models don't quite perform as well. And so, you know, I think when that information is available, maybe one could say, you know, the problem is, like, somewhat solved. From the perspective of structure prediction, when it isn't, it's much more challenging. And I think it's also worth also differentiating the, sometimes we confound a little bit, structure prediction and folding. Folding is the more complex process of actually understanding, like, how it goes from, like, this disordered state into, like, a structured, like, state. And that I don't think we've made that much progress on. But the idea of, like, yeah, going straight to the answer, we've become pretty good at.Brandon [00:08:49]: So there's this protein that is, like, just a long chain and it folds up. Yeah. And so we're good at getting from that long chain in whatever form it was originally to the thing. But we don't know how it necessarily gets to that state. And there might be intermediate states that it's in sometimes that we're not aware of.RJ [00:09:10]: That's right. And that relates also to, like, you know, our general ability to model, like, the different, you know, proteins are not static. They move, they take different shapes based on their energy states. And I think we are, also not that good at understanding the different states that the protein can be in and at what frequency, what probability. So I think the two problems are quite related in some ways. Still a lot to solve. But I think it was very surprising at the time, you know, that even with these evolutionary hints that we were able to, you know, to make such dramatic progress.Brandon [00:09:45]: So I want to ask, why does the intermediate states matter? But first, I kind of want to understand, why do we care? What proteins are shaped like?Gabriel [00:09:54]: Yeah, I mean, the proteins are kind of the machines of our body. You know, the way that all the processes that we have in our cells, you know, work is typically through proteins, sometimes other molecules, sort of intermediate interactions. And through that interactions, we have all sorts of cell functions. And so when we try to understand, you know, a lot of biology, how our body works, how disease work. So we often try to boil it down to, okay, what is going right in case of, you know, our normal biological function and what is going wrong in case of the disease state. And we boil it down to kind of, you know, proteins and kind of other molecules and their interaction. And so when we try predicting the structure of proteins, it's critical to, you know, have an understanding of kind of those interactions. It's a bit like seeing the difference between... Having kind of a list of parts that you would put it in a car and seeing kind of the car in its final form, you know, seeing the car really helps you understand what it does. On the other hand, kind of going to your question of, you know, why do we care about, you know, how the protein falls or, you know, how the car is made to some extent is that, you know, sometimes when something goes wrong, you know, there are, you know, cases of, you know, proteins misfolding. In some diseases and so on, if we don't understand this folding process, we don't really know how to intervene.RJ [00:11:30]: There's this nice line in the, I think it's in the Alpha Fold 2 manuscript, where they sort of discuss also like why we even hopeful that we can target the problem in the first place. And then there's this notion that like, well, four proteins that fold. The folding process is almost instantaneous, which is a strong, like, you know, signal that like, yeah, like we should, we might be... able to predict that this very like constrained thing that, that the protein does so quickly. And of course that's not the case for, you know, for, for all proteins. And there's a lot of like really interesting mechanisms in the cells, but yeah, I remember reading that and thought, yeah, that's somewhat of an insightful point.Gabriel [00:12:10]: I think one of the interesting things about the protein folding problem is that it used to be actually studied. And part of the reason why people thought it was impossible, it used to be studied as kind of like a classical example. Of like an MP problem. Uh, like there are so many different, you know, type of, you know, shapes that, you know, this amino acid could take. And so, this grows combinatorially with the size of the sequence. And so there used to be kind of a lot of actually kind of more theoretical computer science thinking about and studying protein folding as an MP problem. And so it was very surprising also from that perspective, kind of seeing. Machine learning so clear, there is some, you know, signal in those sequences, through evolution, but also through kind of other things that, you know, us as humans, we're probably not really able to, uh, to understand, but that is, models I've, I've learned.Brandon [00:13:07]: And so Andrew White, we were talking to him a few weeks ago and he said that he was following the development of this and that there were actually ASICs that were developed just to solve this problem. So, again, that there were. There were many, many, many millions of computational hours spent trying to solve this problem before AlphaFold. And just to be clear, one thing that you mentioned was that there's this kind of co-evolution of mutations and that you see this again and again in different species. So explain why does that give us a good hint that they're close by to each other? Yeah.RJ [00:13:41]: Um, like think of it this way that, you know, if I have, you know, some amino acid that mutates, it's going to impact everything around it. Right. In three dimensions. And so it's almost like the protein through several, probably random mutations and evolution, like, you know, ends up sort of figuring out that this other amino acid needs to change as well for the structure to be conserved. Uh, so this whole principle is that the structure is probably largely conserved, you know, because there's this function associated with it. And so it's really sort of like different positions compensating for, for each other. I see.Brandon [00:14:17]: Those hints in aggregate give us a lot. Yeah. So you can start to look at what kinds of information about what is close to each other, and then you can start to look at what kinds of folds are possible given the structure and then what is the end state.RJ [00:14:30]: And therefore you can make a lot of inferences about what the actual total shape is. Yeah, that's right. It's almost like, you know, you have this big, like three dimensional Valley, you know, where you're sort of trying to find like these like low energy states and there's so much to search through. That's almost overwhelming. But these hints, they sort of maybe put you in. An area of the space that's already like, kind of close to the solution, maybe not quite there yet. And, and there's always this question of like, how much physics are these models learning, you know, versus like, just pure like statistics. And like, I think one of the thing, at least I believe is that once you're in that sort of approximate area of the solution space, then the models have like some understanding, you know, of how to get you to like, you know, the lower energy, uh, low energy state. And so maybe you have some, some light understanding. Of physics, but maybe not quite enough, you know, to know how to like navigate the whole space. Right. Okay.Brandon [00:15:25]: So we need to give it these hints to kind of get into the right Valley and then it finds the, the minimum or something. Yeah.Gabriel [00:15:31]: One interesting explanation about our awful free works that I think it's quite insightful, of course, doesn't cover kind of the entirety of, of what awful does that is, um, they're going to borrow from, uh, Sergio Chinico for MIT. So he sees kind of awful. Then the interesting thing about awful is God. This very peculiar architecture that we have seen, you know, used, and this architecture operates on this, you know, pairwise context between amino acids. And so the idea is that probably the MSA gives you this first hint about what potential amino acids are close to each other. MSA is most multiple sequence alignment. Exactly. Yeah. Exactly. This evolutionary information. Yeah. And, you know, from this evolutionary information about potential contacts, then is almost as if the model is. of running some kind of, you know, diastro algorithm where it's sort of decoding, okay, these have to be closed. Okay. Then if these are closed and this is connected to this, then this has to be somewhat closed. And so you decode this, that becomes basically a pairwise kind of distance matrix. And then from this rough pairwise distance matrix, you decode kind of theBrandon [00:16:42]: actual potential structure. Interesting. So there's kind of two different things going on in the kind of coarse grain and then the fine grain optimizations. Interesting. Yeah. Very cool.Gabriel [00:16:53]: Yeah. You mentioned AlphaFold3. So maybe we have a good time to move on to that. So yeah, AlphaFold2 came out and it was like, I think fairly groundbreaking for this field. Everyone got very excited. A few years later, AlphaFold3 came out and maybe for some more history, like what were the advancements in AlphaFold3? And then I think maybe we'll, after that, we'll talk a bit about the sort of how it connects to Bolt. But anyway. Yeah. So after AlphaFold2 came out, you know, Jeremy and I got into the field and with many others, you know, the clear problem that, you know, was, you know, obvious after that was, okay, now we can do individual chains. Can we do interactions, interaction, different proteins, proteins with small molecules, proteins with other molecules. And so. So why are interactions important? Interactions are important because to some extent that's kind of the way that, you know, these machines, you know, these proteins have a function, you know, the function comes by the way that they interact with other proteins and other molecules. Actually, in the first place, you know, the individual machines are often, as Jeremy was mentioning, not made of a single chain, but they're made of the multiple chains. And then these multiple chains interact with other molecules to give the function to those. And on the other hand, you know, when we try to intervene of these interactions, think about like a disease, think about like a, a biosensor or many other ways we are trying to design the molecules or proteins that interact in a particular way with what we would call a target protein or target. You know, this problem after AlphaVol2, you know, became clear, kind of one of the biggest problems in the field to, to solve many groups, including kind of ours and others, you know, started making some kind of contributions to this problem of trying to model these interactions. And AlphaVol3 was, you know, was a significant advancement on the problem of modeling interactions. And one of the interesting thing that they were able to do while, you know, some of the rest of the field that really tried to try to model different interactions separately, you know, how protein interacts with small molecules, how protein interacts with other proteins, how RNA or DNA have their structure, they put everything together and, you know, train very large models with a lot of advances, including kind of changing kind of systems. Some of the key architectural choices and managed to get a single model that was able to set this new state-of-the-art performance across all of these different kind of modalities, whether that was protein, small molecules is critical to developing kind of new drugs, protein, protein, understanding, you know, interactions of, you know, proteins with RNA and DNAs and so on.Brandon [00:19:39]: Just to satisfy the AI engineers in the audience, what were some of the key architectural and data, data changes that made that possible?Gabriel [00:19:48]: Yeah, so one critical one that was not necessarily just unique to AlphaFold3, but there were actually a few other teams, including ours in the field that proposed this, was moving from, you know, modeling structure prediction as a regression problem. So where there is a single answer and you're trying to shoot for that answer to a generative modeling problem where you have a posterior distribution of possible structures and you're trying to sample this distribution. And this achieves two things. One is it starts to allow us to try to model more dynamic systems. As we said, you know, some of these structures can actually take multiple structures. And so, you know, you can now model that, you know, through kind of modeling the entire distribution. But on the second hand, from more kind of core modeling questions, when you move from a regression problem to a generative modeling problem, you are really tackling the way that you think about uncertainty in the model in a different way. So if you think about, you know, I'm undecided between different answers, what's going to happen in a regression model is that, you know, I'm going to try to make an average of those different kind of answers that I had in mind. When you have a generative model, what you're going to do is, you know, sample all these different answers and then maybe use separate models to analyze those different answers and pick out the best. So that was kind of one of the critical improvement. The other improvement is that they significantly simplified, to some extent, the architecture, especially of the final model that takes kind of those pairwise representations and turns them into an actual structure. And that now looks a lot more like a more traditional transformer than, you know, like a very specialized equivariant architecture that it was in AlphaFold3.Brandon [00:21:41]: So this is a bitter lesson, a little bit.Gabriel [00:21:45]: There is some aspect of a bitter lesson, but the interesting thing is that it's very far from, you know, being like a simple transformer. This field is one of the, I argue, very few fields in applied machine learning where we still have kind of architecture that are very specialized. And, you know, there are many people that have tried to replace these architectures with, you know, simple transformers. And, you know, there is a lot of debate in the field, but I think kind of that most of the consensus is that, you know, the performance... that we get from the specialized architecture is vastly superior than what we get through a single transformer. Another interesting thing that I think on the staying on the modeling machine learning side, which I think it's somewhat counterintuitive seeing some of the other kind of fields and applications is that scaling hasn't really worked kind of the same in this field. Now, you know, models like AlphaFold2 and AlphaFold3 are, you know, still very large models.RJ [00:29:14]: in a place, I think, where we had, you know, some experience working in, you know, with the data and working with this type of models. And I think that put us already in like a good place to, you know, to produce it quickly. And, you know, and I would even say, like, I think we could have done it quicker. The problem was like, for a while, we didn't really have the compute. And so we couldn't really train the model. And actually, we only trained the big model once. That's how much compute we had. We could only train it once. And so like, while the model was training, we were like, finding bugs left and right. A lot of them that I wrote. And like, I remember like, I was like, sort of like, you know, doing like, surgery in the middle, like stopping the run, making the fix, like relaunching. And yeah, we never actually went back to the start. We just like kept training it with like the bug fixes along the way, which was impossible to reproduce now. Yeah, yeah, no, that model is like, has gone through such a curriculum that, you know, learned some weird stuff. But yeah, somehow by miracle, it worked out.Gabriel [00:30:13]: The other funny thing is that the way that we were training, most of that model was through a cluster from the Department of Energy. But that's sort of like a shared cluster that many groups use. And so we were basically training the model for two days, and then it would go back to the queue and stay a week in the queue. Oh, yeah. And so it was pretty painful. And so we actually kind of towards the end with Evan, the CEO of Genesis, and basically, you know, I was telling him a bit about the project and, you know, kind of telling him about this frustration with the compute. And so luckily, you know, he offered to kind of help. And so we, we got the help from Genesis to, you know, finish up the model. Otherwise, it probably would have taken a couple of extra weeks.Brandon [00:30:57]: Yeah, yeah.Brandon [00:31:02]: And then, and then there's some progression from there.Gabriel [00:31:06]: Yeah, so I would say kind of that, both one, but also kind of these other kind of set of models that came around the same time, were kind of approaching were a big leap from, you know, kind of the previous kind of open source models, and, you know, kind of really kind of approaching the level of AlphaVault 3. But I would still say that, you know, even to this day, there are, you know, some... specific instances where AlphaVault 3 works better. I think one common example is antibody antigen prediction, where, you know, AlphaVault 3 still seems to have an edge in many situations. Obviously, these are somewhat different models. They are, you know, you run them, you obtain different results. So it's, it's not always the case that one model is better than the other, but kind of in aggregate, we still, especially at the time.Brandon [00:32:00]: So AlphaVault 3 is, you know, still having a bit of an edge. We should talk about this more when we talk about Boltzgen, but like, how do you know one is, one model is better than the other? Like you, so you, I make a prediction, you make a prediction, like, how do you know?Gabriel [00:32:11]: Yeah, so easily, you know, the, the great thing about kind of structural prediction and, you know, once we're going to go into the design space of designing new small molecule, new proteins, this becomes a lot more complex. But a great thing about structural prediction is that a bit like, you know, CASP was doing, basically the way that you can evaluate them is that, you know, you train... You know, you train a model on a structure that was, you know, released across the field up until a certain time. And, you know, one of the things that we didn't talk about that was really critical in all this development is the PDB, which is the Protein Data Bank. It's this common resources, basically common database where every biologist publishes their structures. And so we can, you know, train on, you know, all the structures that were put in the PDB until a certain date. And then... And then we basically look for recent structures, okay, which structures look pretty different from anything that was published before, because we really want to try to understand generalization.Brandon [00:33:13]: And then on this new structure, we evaluate all these different models. And so you just know when AlphaFold3 was trained, you know, when you're, you intentionally trained to the same date or something like that. Exactly. Right. Yeah.Gabriel [00:33:24]: And so this is kind of the way that you can somewhat easily kind of compare these models, obviously, that assumes that, you know, the training. You've always been very passionate about validation. I remember like DiffDoc, and then there was like DiffDocL and DocGen. You've thought very carefully about this in the past. Like, actually, I think DocGen is like a really funny story that I think, I don't know if you want to talk about that. It's an interesting like... Yeah, I think one of the amazing things about putting things open source is that we get a ton of feedback from the field. And, you know, sometimes we get kind of great feedback of people. Really like... But honestly, most of the times, you know, to be honest, that's also maybe the most useful feedback is, you know, people sharing about where it doesn't work. And so, you know, at the end of the day, it's critical. And this is also something, you know, across other fields of machine learning. It's always critical to set, to do progress in machine learning, set clear benchmarks. And as, you know, you start doing progress of certain benchmarks, then, you know, you need to improve the benchmarks and make them harder and harder. And this is kind of the progression of, you know, how the field operates. And so, you know, the example of DocGen was, you know, we published this initial model called DiffDoc in my first year of PhD, which was sort of like, you know, one of the early models to try to predict kind of interactions between proteins, small molecules, that we bought a year after AlphaFold2 was published. And now, on the one hand, you know, on these benchmarks that we were using at the time, DiffDoc was doing really well, kind of, you know, outperforming kind of some of the traditional physics-based methods. But on the other hand, you know, when we started, you know, kind of giving these tools to kind of many biologists, and one example was that we collaborated with was the group of Nick Polizzi at Harvard. We noticed, started noticing that there was this clear, pattern where four proteins that were very different from the ones that we're trained on, the models was, was struggling. And so, you know, that seemed clear that, you know, this is probably kind of where we should, you know, put our focus on. And so we first developed, you know, with Nick and his group, a new benchmark, and then, you know, went after and said, okay, what can we change? And kind of about the current architecture to improve this pattern and generalization. And this is the same that, you know, we're still doing today, you know, kind of, where does the model not work, you know, and then, you know, once we have that benchmark, you know, let's try to, through everything we, any ideas that we have of the problem.RJ [00:36:15]: And there's a lot of like healthy skepticism in the field, which I think, you know, is, is, is great. And I think, you know, it's very clear that there's a ton of things, the models don't really work well on, but I think one thing that's probably, you know, undeniable is just like the pace of, pace of progress, you know, and how, how much better we're getting, you know, every year. And so I think if you, you know, if you assume, you know, any constant, you know, rate of progress moving forward, I think things are going to look pretty cool at some point in the future.Gabriel [00:36:42]: ChatGPT was only three years ago. Yeah, I mean, it's wild, right?RJ [00:36:45]: Like, yeah, yeah, yeah, it's one of those things. Like, you've been doing this. Being in the field, you don't see it coming, you know? And like, I think, yeah, hopefully we'll, you know, we'll, we'll continue to have as much progress we've had the past few years.Brandon [00:36:55]: So this is maybe an aside, but I'm really curious, you get this great feedback from the, from the community, right? By being open source. My question is partly like, okay, yeah, if you open source and everyone can copy what you did, but it's also maybe balancing priorities, right? Where you, like all my customers are saying. I want this, there's all these problems with the model. Yeah, yeah. But my customers don't care, right? So like, how do you, how do you think about that? Yeah.Gabriel [00:37:26]: So I would say a couple of things. One is, you know, part of our goal with Bolts and, you know, this is also kind of established as kind of the mission of the public benefit company that we started is to democratize the access to these tools. But one of the reasons why we realized that Bolts needed to be a company, it couldn't just be an academic project is that putting a model on GitHub is definitely not enough to get, you know, chemists and biologists, you know, across, you know, both academia, biotech and pharma to use your model to, in their therapeutic programs. And so a lot of what we think about, you know, at Bolts beyond kind of the, just the models is thinking about all the layers. The layers that come on top of the models to get, you know, from, you know, those models to something that can really enable scientists in the industry. And so that goes, you know, into building kind of the right kind of workflows that take in kind of, for example, the data and try to answer kind of directly that those problems that, you know, the chemists and the biologists are asking, and then also kind of building the infrastructure. And so this to say that, you know, even with models fully open. You know, we see a ton of potential for, you know, products in the space and the critical part about a product is that even, you know, for example, with an open source model, you know, running the model is not free, you know, as we were saying, these are pretty expensive model and especially, and maybe we'll get into this, you know, these days we're seeing kind of pretty dramatic inference time scaling of these models where, you know, the more you run them, the better the results are. But there, you know, you see. You start getting into a point that compute and compute costs becomes a critical factor. And so putting a lot of work into building the right kind of infrastructure, building the optimizations and so on really allows us to provide, you know, a much better service potentially to the open source models. That to say, you know, even though, you know, with a product, we can provide a much better service. I do still think, and we will continue to put a lot of our models open source because the critical kind of role. I think of open source. Models is, you know, helping kind of the community progress on the research and, you know, from which we, we all benefit. And so, you know, we'll continue to on the one hand, you know, put some of our kind of base models open source so that the field can, can be on top of it. And, you know, as we discussed earlier, we learn a ton from, you know, the way that the field uses and builds on top of our models, but then, you know, try to build a product that gives the best experience possible to scientists. So that, you know, like a chemist or a biologist doesn't need to, you know, spin off a GPU and, you know, set up, you know, our open source model in a particular way, but can just, you know, a bit like, you know, I, even though I am a computer scientist, machine learning scientist, I don't necessarily, you know, take a open source LLM and try to kind of spin it off. But, you know, I just maybe open a GPT app or a cloud code and just use it as an amazing product. We kind of want to give the same experience. So this front world.Brandon [00:40:40]: I heard a good analogy yesterday that a surgeon doesn't want the hospital to design a scalpel, right?Brandon [00:40:48]: So just buy the scalpel.RJ [00:40:50]: You wouldn't believe like the number of people, even like in my short time, you know, between AlphaFold3 coming out and the end of the PhD, like the number of people that would like reach out just for like us to like run AlphaFold3 for them, you know, or things like that. Just because like, you know, bolts in our case, you know, just because it's like. It's like not that easy, you know, to do that, you know, if you're not a computational person. And I think like part of the goal here is also that, you know, we continue to obviously build the interface with computational folks, but that, you know, the models are also accessible to like a larger, broader audience. And then that comes from like, you know, good interfaces and stuff like that.Gabriel [00:41:27]: I think one like really interesting thing about bolts is that with the release of it, you didn't just release a model, but you created a community. Yeah. Did that community, it grew very quickly. Did that surprise you? And like, what is the evolution of that community and how is that fed into bolts?RJ [00:41:43]: If you look at its growth, it's like very much like when we release a new model, it's like, there's a big, big jump, but yeah, it's, I mean, it's been great. You know, we have a Slack community that has like thousands of people on it. And it's actually like self-sustaining now, which is like the really nice part because, you know, it's, it's almost overwhelming, I think, you know, to be able to like answer everyone's questions and help. It's really difficult, you know. The, the few people that we were, but it ended up that like, you know, people would answer each other's questions and like, sort of like, you know, help one another. And so the Slack, you know, has been like kind of, yeah, self, self-sustaining and that's been, it's been really cool to see.RJ [00:42:21]: And, you know, that's, that's for like the Slack part, but then also obviously on GitHub as well. We've had like a nice, nice community. You know, I think we also aspire to be even more active on it, you know, than we've been in the past six months, which has been like a bit challenging, you know, for us. But. Yeah, the community has been, has been really great and, you know, there's a lot of papers also that have come out with like new evolutions on top of bolts and it's surprised us to some degree because like there's a lot of models out there. And I think like, you know, sort of people converging on that was, was really cool. And, you know, I think it speaks also, I think, to the importance of like, you know, when, when you put code out, like to try to put a lot of emphasis and like making it like as easy to use as possible and something we thought a lot about when we released the code base. You know, it's far from perfect, but, you know.Brandon [00:43:07]: Do you think that that was one of the factors that caused your community to grow is just the focus on easy to use, make it accessible? I think so.RJ [00:43:14]: Yeah. And we've, we've heard it from a few people over the, over the, over the years now. And, you know, and some people still think it should be a lot nicer and they're, and they're right. And they're right. But yeah, I think it was, you know, at the time, maybe a little bit easier than, than other things.Gabriel [00:43:29]: The other thing part, I think led to, to the community and to some extent, I think, you know, like the somewhat the trust in the community. Kind of what we, what we put out is the fact that, you know, it's not really been kind of, you know, one model, but, and maybe we'll talk about it, you know, after Boltz 1, you know, there were maybe another couple of models kind of released, you know, or open source kind of soon after. We kind of continued kind of that open source journey or at least Boltz 2, where we are not only improving kind of structure prediction, but also starting to do affinity predictions, understanding kind of the strength of the interactions between these different models, which is this critical component. critical property that you often want to optimize in discovery programs. And then, you know, more recently also kind of protein design model. And so we've sort of been building this suite of, of models that come together, interact with one another, where, you know, kind of, there is almost an expectation that, you know, we, we take very at heart of, you know, always having kind of, you know, across kind of the entire suite of different tasks, the best or across the best. model out there so that it's sort of like our open source tool can be kind of the go-to model for everybody in the, in the industry. I really want to talk about Boltz 2, but before that, one last question in this direction, was there anything about the community which surprised you? Were there any, like, someone was doing something and you're like, why would you do that? That's crazy. Or that's actually genius. And I never would have thought about that.RJ [00:45:01]: I mean, we've had many contributions. I think like some of the. Interesting ones, like, I mean, we had, you know, this one individual who like wrote like a complex GPU kernel, you know, for part of the architecture on a piece of, the funny thing is like that piece of the architecture had been there since AlphaFold 2, and I don't know why it took Boltz for this, you know, for this person to, you know, to decide to do it, but that was like a really great contribution. We've had a bunch of others, like, you know, people figuring out like ways to, you know, hack the model to do something. They click peptides, like, you know, there's, I don't know if there's any other interesting ones come to mind.Gabriel [00:45:41]: One cool one, and this was, you know, something that initially was proposed as, you know, as a message in the Slack channel by Tim O'Donnell was basically, he was, you know, there are some cases, especially, for example, we discussed, you know, antibody-antigen interactions where the models don't necessarily kind of get the right answer. What he noticed is that, you know, the models were somewhat stuck into predicting kind of the antibodies. And so he basically ran the experiments in this model, you can condition, basically, you can give hints. And so he basically gave, you know, random hints to the model, basically, okay, you should bind to this residue, you should bind to the first residue, or you should bind to the 11th residue, or you should bind to the 21st residue, you know, basically every 10 residues scanning the entire antigen.Brandon [00:46:33]: Residues are the...Gabriel [00:46:34]: The amino acids. The amino acids, yeah. So the first amino acids. The 11 amino acids, and so on. So it's sort of like doing a scan, and then, you know, conditioning the model to predict all of them, and then looking at the confidence of the model in each of those cases and taking the top. And so it's sort of like a very somewhat crude way of doing kind of inference time search. But surprisingly, you know, for antibody-antigen prediction, it actually kind of helped quite a bit. And so there's some, you know, interesting ideas that, you know, obviously, as kind of developing the model, you say kind of, you know, wow. This is why would the model, you know, be so dumb. But, you know, it's very interesting. And that, you know, leads you to also kind of, you know, start thinking about, okay, how do I, can I do this, you know, not with this brute force, but, you know, in a smarter way.RJ [00:47:22]: And so we've also done a lot of work on that direction. And that speaks to, like, the, you know, the power of scoring. We're seeing that a lot. I'm sure we'll talk about it more when we talk about BullsGen. But, you know, our ability to, like, take a structure and determine that that structure is, like... Good. You know, like, somewhat accurate. Whether that's a single chain or, like, an interaction is a really powerful way of improving, you know, the models. Like, sort of like, you know, if you can sample a ton and you assume that, like, you know, if you sample enough, you're likely to have, like, you know, the good structure. Then it really just becomes a ranking problem. And, you know, now we're, you know, part of the inference time scaling that Gabby was talking about is very much that. It's like, you know, the more we sample, the more we, like, you know, the ranking model. The ranking model ends up finding something it really likes. And so I think our ability to get better at ranking, I think, is also what's going to enable sort of the next, you know, next big, big breakthroughs. Interesting.Brandon [00:48:17]: But I guess there's a, my understanding, there's a diffusion model and you generate some stuff and then you, I guess, it's just what you said, right? Then you rank it using a score and then you finally... And so, like, can you talk about those different parts? Yeah.Gabriel [00:48:34]: So, first of all, like, the... One of the critical kind of, you know, beliefs that we had, you know, also when we started working on Boltz 1 was sort of like the structure prediction models are somewhat, you know, our field version of some foundation models, you know, learning about kind of how proteins and other molecules interact. And then we can leverage that learning to do all sorts of other things. And so with Boltz 2, we leverage that learning to do affinity predictions. So understanding kind of, you know, if I give you this protein, this molecule. How tightly is that interaction? For Boltz 1, what we did was taking kind of that kind of foundation models and then fine tune it to predict kind of entire new proteins. And so the way basically that that works is sort of like instead of for the protein that you're designing, instead of fitting in an actual sequence, you fit in a set of blank tokens. And you train the models to, you know, predict both the structure of kind of that protein. The structure also, what the different amino acids of that proteins are. And so basically the way that Boltz 1 operates is that you feed a target protein that you may want to kind of bind to or, you know, another DNA, RNA. And then you feed the high level kind of design specification of, you know, what you want your new protein to be. For example, it could be like an antibody with a particular framework. It could be a peptide. It could be many other things. And that's with natural language or? And that's, you know, basically, you know, prompting. And we have kind of this sort of like spec that you specify. And, you know, you feed kind of this spec to the model. And then the model translates this into, you know, a set of, you know, tokens, a set of conditioning to the model, a set of, you know, blank tokens. And then, you know, basically the codes as part of the diffusion models, the codes. It's a new structure and a new sequence for your protein. And, you know, basically, then we take that. And as Jeremy was saying, we are trying to score it and, you know, how good of a binder it is to that original target.Brandon [00:50:51]: You're using basically Boltz to predict the folding and the affinity to that molecule. So and then that kind of gives you a score? Exactly.Gabriel [00:51:03]: So you use this model to predict the folding. And then you do two things. One is that you predict the structure and with something like Boltz2, and then you basically compare that structure with what the model predicted, what Boltz2 predicted. And this is sort of like in the field called consistency. It's basically you want to make sure that, you know, the structure that you're predicting is actually what you're trying to design. And that gives you a much better confidence that, you know, that's a good design. And so that's the first filtering. And the second filtering that we did as part of kind of the Boltz2 pipeline that was released is that we look at the confidence that the model has in the structure. Now, unfortunately, kind of going to your question of, you know, predicting affinity, unfortunately, confidence is not a very good predictor of affinity. And so one of the things that we've actually done a ton of progress, you know, since we released Boltz2.Brandon [00:52:03]: And kind of we have some new results that we are going to kind of announce soon is kind of, you know, the ability to get much better hit rates when instead of, you know, trying to rely on confidence of the model, we are actually directly trying to predict the affinity of that interaction. Okay. Just backing up a minute. So your diffusion model actually predicts not only the protein sequence, but also the folding of it. Exactly.Gabriel [00:52:32]: And actually, you can... One of the big different things that we did compared to other models in the space, and, you know, there were some papers that had already kind of done this before, but we really scaled it up was, you know, basically somewhat merging kind of the structure prediction and the sequence prediction into almost the same task. And so the way that Boltz2 works is that you are basically the only thing that you're doing is predicting the structure. So the only sort of... Supervision is we give you a supervision on the structure, but because the structure is atomic and, you know, the different amino acids have a different atomic composition, basically from the way that you place the atoms, we also understand not only kind of the structure that you wanted, but also the identity of the amino acid that, you know, the models believed was there. And so we've basically, instead of, you know, having these two supervision signals, you know, one discrete, one continuous. That somewhat, you know, don't interact well together. We sort of like build kind of like an encoding of, you know, sequences in structures that allows us to basically use exactly the same supervision signal that we were using to Boltz2 that, you know, you know, largely similar to what AlphaVol3 proposed, which is very scalable. And we can use that to design new proteins. Oh, interesting.RJ [00:53:58]: Maybe a quick shout out to Hannes Stark on our team who like did all this work. Yeah.Gabriel [00:54:04]: Yeah, that was a really cool idea. I mean, like looking at the paper and there's this is like encoding or you just add a bunch of, I guess, kind of atoms, which can be anything, and then they get sort of rearranged and then basically plopped on top of each other so that and then that encodes what the amino acid is. And there's sort of like a unique way of doing this. It was that was like such a really such a cool, fun idea.RJ [00:54:29]: I think that idea was had existed before. Yeah, there were a couple of papers.Gabriel [00:54:33]: Yeah, I had proposed this and and Hannes really took it to the large scale.Brandon [00:54:39]: In the paper, a lot of the paper for Boltz2Gen is dedicated to actually the validation of the model. In my opinion, all the people we basically talk about feel that this sort of like in the wet lab or whatever the appropriate, you know, sort of like in real world validation is the whole problem or not the whole problem, but a big giant part of the problem. So can you talk a little bit about the highlights? From there, that really because to me, the results are impressive, both from the perspective of the, you know, the model and also just the effort that went into the validation by a large team.Gabriel [00:55:18]: First of all, I think I should start saying is that both when we were at MIT and Thomas Yacolas and Regina Barzillai's lab, as well as at Boltz, you know, we are not a we're not a biolab and, you know, we are not a therapeutic company. And so to some extent, you know, we were first forced to, you know, look outside of, you know, our group, our team to do the experimental validation. One of the things that really, Hannes, in the team pioneer was the idea, OK, can we go not only to, you know, maybe a specific group and, you know, trying to find a specific system and, you know, maybe overfit a bit to that system and trying to validate. But how can we test this model? So. Across a very wide variety of different settings so that, you know, anyone in the field and, you know, printing design is, you know, such a kind of wide task with all sorts of different applications from therapeutic to, you know, biosensors and many others that, you know, so can we get a validation that is kind of goes across many different tasks? And so he basically put together, you know, I think it was something like, you know, 25 different. You know, academic and industry labs that committed to, you know, testing some of the designs from the model and some of this testing is still ongoing and, you know, giving results kind of back to us in exchange for, you know, hopefully getting some, you know, new great sequences for their task. And he was able to, you know, coordinate this, you know, very wide set of, you know, scientists and already in the paper, I think we. Shared results from, I think, eight to 10 different labs kind of showing results from, you know, designing peptides, designing to target, you know, ordered proteins, peptides targeting disordered proteins, which are results, you know, of designing proteins that bind to small molecules, which are results of, you know, designing nanobodies and across a wide variety of different targets. And so that's sort of like. That gave to the paper a lot of, you know, validation to the model, a lot of validation that was kind of wide.Brandon [00:57:39]: And so those would be therapeutics for those animals or are they relevant to humans as well? They're relevant to humans as well.Gabriel [00:57:45]: Obviously, you need to do some work into, quote unquote, humanizing them, making sure that, you know, they have the right characteristics to so they're not toxic to humans and so on.RJ [00:57:57]: There are some approved medicine in the market that are nanobodies. There's a general. General pattern, I think, in like in trying to design things that are smaller, you know, like it's easier to manufacture at the same time, like that comes with like potentially other challenges, like maybe a little bit less selectivity than like if you have something that has like more hands, you know, but the yeah, there's this big desire to, you know, try to design many proteins, nanobodies, small peptides, you know, that just are just great drug modalities.Brandon [00:58:27]: Okay. I think we were left off. We were talking about validation. Validation in the lab. And I was very excited about seeing like all the diverse validations that you've done. Can you go into some more detail about them? Yeah. Specific ones. Yeah.RJ [00:58:43]: The nanobody one. I think we did. What was it? 15 targets. Is that correct? 14. 14 targets. Testing. So we typically the way this works is like we make a lot of designs. All right. On the order of like tens of thousands. And then we like rank them and we pick like the top. And in this case, and was 15 right for each target and then we like measure sort of like the success rates, both like how many targets we were able to get a binder for and then also like more generally, like out of all of the binders that we designed, how many actually proved to be good binders. Some of the other ones I think involved like, yeah, like we had a cool one where there was a small molecule or design a protein that binds to it. That has a lot of like interesting applications, you know, for example. Like Gabri mentioned, like biosensing and things like that, which is pretty cool. We had a disordered protein, I think you mentioned also. And yeah, I think some of those were some of the highlights. Yeah.Gabriel [00:59:44]: So I would say that the way that we structure kind of some of those validations was on the one end, we have validations across a whole set of different problems that, you know, the biologists that we were working with came to us with. So we were trying to. For example, in some of the experiments, design peptides that would target the RACC, which is a target that is involved in metabolism. And we had, you know, a number of other applications where we were trying to design, you know, peptides or other modalities against some other therapeutic relevant targets. We designed some proteins to bind small molecules. And then some of the other testing that we did was really trying to get like a more broader sense. So how does the model work, especially when tested, you know, on somewhat generalization? So one of the things that, you know, we found with the field was that a lot of the validation, especially outside of the validation that was on specific problems, was done on targets that have a lot of, you know, known interactions in the training data. And so it's always a bit hard to understand, you know, how much are these models really just regurgitating kind of what they've seen or trying to imitate. What they've seen in the training data versus, you know, really be able to design new proteins. And so one of the experiments that we did was to take nine targets from the PDB, filtering to things where there is no known interaction in the PDB. So basically the model has never seen kind of this particular protein bound or a similar protein bound to another protein. So there is no way that. The model from its training set can sort of like say, okay, I'm just going to kind of tweak something and just imitate this particular kind of interaction. And so we took those nine proteins. We worked with adaptive CRO and basically tested, you know, 15 mini proteins and 15 nanobodies against each one of them. And the very cool thing that we saw was that on two thirds of those targets, we were able to, from this 15 design, get nanomolar binders, nanomolar, roughly speaking, just a measure of, you know, how strongly kind of the interaction is, roughly speaking, kind of like a nanomolar binder is approximately the kind of binding strength or binding that you need for a therapeutic. Yeah. So maybe switching directions a bit. Bolt's lab was just announced this week or was it last week? Yeah. This is like your. First, I guess, product, if that's if you want to call it that. Can you talk about what Bolt's lab is and yeah, you know, what you hope that people take away from this? Yeah.RJ [01:02:44]: You know, as we mentioned, like I think at the very beginning is the goal with the product has been to, you know, address what the models don't on their own. And there's largely sort of two categories there. I'll split it in three. The first one. It's one thing to predict, you know, a single interaction, for example, like a single structure. It's another to like, you know, very effectively search a space, a design space to produce something of value. What we found, like sort of building on this product is that there's a lot of steps involved, you know, in that there's certainly need to like, you know, accompany the user through, you know, one of those steps, for example, is like, you know, the creation of the target itself. You know, how do we make sure that the model has like a good enough understanding of the target? So we can like design something and there's all sorts of tricks, you know, that you can do to improve like a particular, you know, structure prediction. And so that's sort of like, you know, the first stage. And then there's like this stage of like, you know, designing and searching the space efficiently. You know, for something like BullsGen, for example, like you, you know, you design many things and then you rank them, for example, for small molecule process, a little bit more complicated. We actually need to also make sure that the molecules are synthesizable. And so the way we do that is that, you know, we have a generative model that learns. To use like appropriate building blocks such that, you know, it can design within a space that we know is like synthesizable. And so there's like, you know, this whole pipeline really of different models involved in being able to design a molecule. And so that's been sort of like the first thing we call them agents. We have a protein agent and we have a small molecule design agents. And that's really like at the core of like what powers, you know, the BullsLab platform.Brandon [01:04:22]: So these agents, are they like a language model wrapper or they're just like your models and you're just calling them agents? A lot. Yeah. Because they, they, they sort of perform a function on behalf of.RJ [01:04:33]: They're more of like a, you know, a recipe, if you wish. And I think we use that term sort of because of, you know, sort of the complex pipelining and automation, you know, that goes into like all this plumbing. So that's the first part of the product. The second part is the infrastructure. You know, we need to be able to do this at very large scale for any one, you know, group that's doing a design campaign. Let's say you're designing, you know, I'd say a hundred thousand possible candidates. Right. To find the good one that is, you know, a very large amount of compute, you know, for small molecules, it's on the order of like a few seconds per designs for proteins can be a bit longer. And so, you know, ideally you want to do that in parallel, otherwise it's going to take you weeks. And so, you know, we've put a lot of effort into like, you know, our ability to have a GPU fleet that allows any one user, you know, to be able to do this kind of like large parallel search.Brandon [01:05:23]: So you're amortizing the cost over your users. Exactly. Exactly.RJ [01:05:27]: And, you know, to some degree, like it's whether you. Use 10,000 GPUs for like, you know, a minute is the same cost as using, you know, one GPUs for God knows how long. Right. So you might as well try to parallelize if you can. So, you know, a lot of work has gone, has gone into that, making it very robust, you know, so that we can have like a lot of people on the platform doing that at the same time. And the third one is, is the interface and the interface comes in, in two shapes. One is in form of an API and that's, you know, really suited for companies that want to integrate, you know, these pipelines, these agents.RJ [01:06:01]: So we're already partnering with, you know, a few distributors, you know, that are gonna integrate our API. And then the second part is the user interface. And, you know, we, we've put a lot of thoughts also into that. And this is when I, I mentioned earlier, you know, this idea of like broadening the audience. That's kind of what the, the user interface is about. And we've built a lot of interesting features in it, you know, for example, for collaboration, you know, when you have like potentially multiple medicinal chemists or. We're going through the results and trying to pick out, okay, like what are the molecules that we're going to go and test in the lab? It's powerful for them to be able to, you know, for example, each provide their own ranking and then do consensus building. And so there's a lot of features around launching these large jobs, but also around like collaborating on analyzing the results that we try to solve, you know, with that part of the platform. So Bolt's lab is sort of a combination of these three objectives into like one, you know, sort of cohesive platform. Who is this accessible to? Everyone. You do need to request access today. We're still like, you know, sort of ramping up the usage, but anyone can request access. If you are an academic in particular, we, you know, we provide a fair amount of free credit so you can play with the platform. If you are a startup or biotech, you may also, you know, reach out and we'll typically like actually hop on a call just to like understand what you're trying to do and also provide a lot of free credit to get started. And of course, also with larger companies, we can deploy this platform in a more like secure environment. And so that's like more like customizing. You know, deals that we make, you know, with the partners, you know, and that's sort of the ethos of Bolt. I think this idea of like servicing everyone and not necessarily like going after just, you know, the really large enterprises. And that starts from the open source, but it's also, you know, a key design principle of the product itself.Gabriel [01:07:48]: One thing I was thinking about with regards to infrastructure, like in the LLM space, you know, the cost of a token has gone down by I think a factor of a thousand or so over the last three years, right? Yeah. And is it possible that like essentially you can exploit economies of scale and infrastructure that you can make it cheaper to run these things yourself than for any person to roll their own system? A hundred percent. Yeah.RJ [01:08:08]: I mean, we're already there, you know, like running Bolts on our platform, especially on a large screen is like considerably cheaper than it would probably take anyone to put the open source model out there and run it. And on top of the infrastructure, like one of the things that we've been working on is accelerating the models. So, you know. Our small molecule screening pipeline is 10x faster on Bolts Lab than it is in the open source, you know, and that's also part of like, you know, building a product, you know, of something that scales really well. And we really wanted to get to a point where like, you know, we could keep prices very low in a way that it would be a no-brainer, you know, to use Bolts through our platform.Gabriel [01:08:52]: How do you think about validation of your like agentic systems? Because, you know, as you were saying earlier. Like we're AlphaFold style models are really good at, let's say, monomeric, you know, proteins where you have, you know, co-evolution data. But now suddenly the whole point of this is to design something which doesn't have, you know, co-evolution data, something which is really novel. So now you're basically leaving the domain that you thought was, you know, that you know you are good at. So like, how do you validate that?RJ [01:09:22]: Yeah, I like every complete, but there's obviously, you know, a ton of computational metrics. That we rely on, but those are only take you so far. You really got to go to the lab, you know, and test, you know, okay, with this method A and this method B, how much better are we? You know, how much better is my, my hit rate? How stronger are my binders? Also, it's not just about hit rate. It's also about how good the binders are. And there's really like no way, nowhere around that. I think we're, you know, we've really ramped up the amount of experimental validation that we do so that we like really track progress, you know, as scientifically sound, you know. Yeah. As, as possible out of this, I think.Gabriel [01:10:00]: Yeah, no, I think, you know, one thing that is unique about us and maybe companies like us is that because we're not working on like maybe a couple of therapeutic pipelines where, you know, our validation would be focused on those. We, when we do an experimental validation, we try to test it across tens of targets. And so that on the one end, we can get a much more statistically significant result and, and really allows us to make progress. From the methodological side without being, you know, steered by, you know, overfitting on any one particular system. And of course we choose, you know, w

What actually happens when AI stops being a cloud-only experiment and starts running on desks, in labs, and inside real teams trying to ship real work? In this episode, I sit down with Logan Lawler, Senior Director at Dell Technologies, to unpack how AI workloads are really being built and supported on the ground today. Logan leads Dell's Precision and Pro Max AI Solutions business and hosts Dell's own Reshaping Workflows podcast, giving him a rare vantage point into how engineers, developers, creatives, and data teams are actually working, not how marketing slides suggest they should be. We start by cutting through the noise around AI PCs. At every conference stage, Logan breaks down what genuinely matters when choosing hardware for AI work. CPUs, GPUs, NPUs, memory, and software stacks all play different roles, and misunderstanding those roles often leads teams to overspend or underspec. Logan explains why all AI workstations qualify as AI PCs, but not all AI PCs are suitable for serious AI work, and why GPUs remain central for anyone doing real model development, fine-tuning, or inference at scale. From there, the conversation shifts to a broader architectural rethink. As AI workloads grow heavier and data sensitivity increases, many organizations are reconsidering where compute should live. Logan shares how GPU-powered Dell workstations, storage-rich environments, and hybrid cloud setups are giving teams more control over performance, cost, and data. We explore why local compute is becoming attractive again, how modern GPUs now rival small server setups, and why hybrid workflows, local for development and cloud for deployment, are becoming the default rather than the exception. One of the most compelling parts of the discussion comes when Logan connects hardware choices back to business reality. Drawing on real-world examples, he explains how teams use local AI environments to move faster, reduce cloud costs, and avoid getting locked into architectures that are hard to unwind later. This is not about abandoning the cloud, but about being intentional from the start, mainly as AI usage spreads beyond developers into marketing, operations, and everyday business roles. We also step back to reflect on a deeper challenge. As AI becomes easier to use, what happens to critical thinking, curiosity, and learning? Logan shares a candid perspective, shaped by his experiences as a parent, technologist, and podcast host, raising questions about how tools should support rather than replace thinking. If you are trying to make sense of AI PCs, local versus cloud compute, or how teams are really reshaping workflows with AI hardware today, this conversation offers grounded insight from someone living at the center of it. Are we designing systems that genuinely empower people to think better and build faster, or are we sleepwalking into decisions we will regret later? How do you want your own AI workflow to evolve? Useful Links TLDR AI newsletter and the Neurons. The Reshaping Workflows podcast Connect with Logan Lawler Follow Dell Technologies on LinkedIn

Infrastructure was passé…uncool. Difficult to get dollars from Private Equity and Growth funds, and almost impossible to get a VC fund interested. Now?! Now, it's cool. Infrastructure seems to be having a Renaissance, a full on Rebirth, not just fueled by commercial interests (e.g. advent of AI), but also by industrial policy and geopolitical considerations. In this episode of Tech Deciphered, we explore what's cool in the infrastructure spaces, including mega trends in semiconductors, energy, networking & connectivity, manufacturing Navigation: Intro We're back to building things Why now: the 5 forces behind the renaissance Semiconductors: compute is the new oil Networking & connectivity: digital highways get rebuilt Energy: rebuilding the power stack (not just renewables) Manufacturing: the return of “atoms + bits” Wrap: what it means for startups, incumbents, and investors Conclusion Our co-hosts: Bertrand Schmitt, Entrepreneur in Residence at Red River West, co-founder of App Annie / Data.ai, business angel, advisor to startups and VC funds, @bschmitt Nuno Goncalves Pedro, Investor, Managing Partner, Founder at Chamaeleon, @ngpedro Our show: Tech DECIPHERED brings you the Entrepreneur and Investor views on Big Tech, VC and Start-up news, opinion pieces and research. We decipher their meaning, and add inside knowledge and context. Being nerds, we also discuss the latest gadgets and pop culture news Subscribe To Our Podcast Nuno Gonçalves Pedro Introduction Welcome to episode 73 of Tech Deciphered, Infrastructure, the Rebirth or Renaissance. Infrastructure was passé, it wasn’t cool, but all of a sudden now everyone’s talking about network, talking about compute and semiconductors, talking about logistics, talking about energy. What gives? What’s happened? It was impossible in the past to get any funds, venture capital, even, to be honest, some private equity funds or growth funds interested in some of these areas, but now all of a sudden everyone thinks it’s cool. The infrastructure seems to be having a renaissance, a full-on rebirth. In this episode, we will explore in which cool ways the infrastructure spaces are moving and what’s leading to it. We will deep dive into the forces that are leading us to this. We will deep dive into semiconductors, networking and connectivity, energy, manufacturing, and then we’ll wrap up. Bertrand, so infrastructure is cool now. Bertrand Schmitt We're back to building things Yes. I thought software was going to eat the world. I cannot believe it was then, maybe even 15 years ago, from Andreessen, that quote about software eating the world. I guess it’s an eternal balance. Sometimes you go ahead of yourself, you build a lot of software stack, and at some point, you need the hardware to run this software stack, and there is only so much the bits can do in a world of atoms. Nuno Gonçalves Pedro Obviously, we’ve gone through some of this before. I think what we’re going through right now is AI is eating the world, and because AI is eating the world, it’s driving a lot of this infrastructure building that we need. We don’t have enough energy to be consumed by all these big data centers and hyperscalers. We need to be innovative around network as well because of the consumption in terms of network bandwidth that is linked to that consumption as well. In some ways, it’s not software eating the world, AI is eating the world. Because AI is eating the world, we need to rethink everything around infrastructure and infrastructure becoming cool again. Bertrand Schmitt There is something deeper in this. It’s that the past 10, even 15 years were all about SaaS before AI. SaaS, interestingly enough, was very energy-efficient. When I say SaaS, I mean cloud computing at large. What I mean by energy-efficient is that actually cloud computing help make energy use more efficient because instead of companies having their own separate data centers in many locations, sometimes poorly run from an industrial perspective, replace their own privately run data center with data center run by the super scalers, the hyperscalers of the world. These data centers were run much better in terms of how you manage the coolings, the energy efficiency, the rack density, all of this stuff. Actually, the cloud revolution didn’t increase the use of electricity. The cloud revolution was actually a replacement from your private data center to the hyperscaler data center, which was energy efficient. That’s why we didn’t, even if we are always talking about that growth of cloud computing, we were never feeling the pinch in term of electricity. As you say, we say it all changed because with AI, it was not a simple “Replacement” of locally run infrastructure to a hyperscaler run infrastructure. It was truly adding on top of an existing infrastructure, a new computing infrastructure in a way out of nowhere. Not just any computing infrastructure, an energy infrastructure that was really, really voracious in term of energy use. Nuno Gonçalves Pedro There was one other effect. Obviously, we’ve discussed before, we are in a bubble. We won’t go too much into that today. But the previous big bubble in tech, which is in the late ’90s, there was a lot of infrastructure built. We thought the internet was going to take over back then. It didn’t take over immediately, but there was a lot of network connectivity, bandwidth built back in the day. Companies imploded because of that as well, or had to restructure and go in their chapter 11. A lot of the big telco companies had their own issues back then, etc., but a lot of infrastructure was built back then for this advent of the internet, which would then take a long time to come. In some ways, to your point, there was a lot of latent supply that was built that was around that for a while wasn’t used, but then it was. Now it’s been used, and now we need new stuff. That’s why I feel now we’re having the new moment of infrastructure, new moment of moving forward, aligned a little bit with what you just said around cloud computing and the advent of SaaS, but also around the fact that we had a lot of buildup back in the late ’90s, early ’90s, which we’re now still reaping the benefits on in today’s world. Bertrand Schmitt Yeah, that’s actually a great point because what was built in the late ’90s, there was a lot of fibre that was built. Laying out the fibre either across countries, inside countries. This fibre, interestingly enough, you could just change the computing on both sides of the fibre, the routing, the modems, and upgrade the capacity of the fibre. But the fibre was the same in between. The big investment, CapEx investment, was really lying down that fibre, but then you could really upgrade easily. Even if both ends of the fibre were either using very old infrastructure from the ’90s or were actually dark and not being put to use, step by step, it was being put to use, equipment was replaced, and step by step, you could keep using more and more of this fibre. It was a very interesting development, as you say, because it could be expanded over the years, where if we talk about GPUs, use for AI, GPUs, the interesting part is actually it’s totally the opposite. After a few years, it’s useless. Some like Google, will argue that they can depreciate over 5, 6 years, even some GPUs. But at the end of the day, the difference in perf and energy efficiency of the GPUs means that if you are energy constrained, you just want to replace the old one even as young as three-year-old. You have to look at Nvidia increasing spec, generation after generation. It’s pretty insane. It’s usually at least 3X year over year in term of performance. Nuno Gonçalves Pedro At this moment in time, it’s very clear that it’s happening. Why now: the 5 forces behind the renaissance Maybe let’s deep dive into why it’s happening now. What are the key forces around this? We’ve identified, I think, five forces that are particularly vital that lead to the world we’re in right now. One we’ve already talked about, which is AI, the demand shock and everything that’s happened because of AI. Data centers drive power demand, drive grid upgrades, drive innovative ways of getting energy, drive chips, drive networking, drive cooling, drive manufacturing, drive all the things that we’re going to talk in just a bit. One second element that we could probably highlight in terms of the forces that are behind this is obviously where we are in terms of cost curves around technology. Obviously, a lot of things are becoming much cheaper. The simulation of physical behaviours has become a lot more cheap, which in itself, this becomes almost a vicious cycle in of itself, then drives the adoption of more and more AI and stuff. But anyway, the simulation is becoming more and more accessible, so you can do a lot of simulation with digital twins and other things off the real world before you go into the real world. Robotics itself is becoming, obviously, cheaper. Hardware, a lot of the hardware is becoming cheaper. Computer has become cheaper as well. Obviously, there’s a lot of cost curves that have aligned that, and that’s maybe the second force that I would highlight. Obviously, funds are catching up. We’ll leave that a little bit to the end. We’ll do a wrap-up and talk a little bit about the implications to investors. But there’s a lot of capital out there, some capital related to industrial policy, other capital related to private initiative, private equity, growth funds, even venture capital, to be honest, and a few other elements on that. That would be a third force that I would highlight. Bertrand Schmitt Yes. Interestingly enough, in terms of capital use, and we’ll talk more about this, but some firms, if we are talking about energy investment, it was very difficult to invest if you are not investing in green energy. Now I think more and more firms and banks are willing to invest or support different type of energy infrastructure, not just, “Green energy.” That’s an interesting development because at some point it became near impossible to invest more in gas development, in oil development in the US or in most Western countries. At least in the US, this is dramatically changing the framework. Nuno Gonçalves Pedro Maybe to add the two last forces that I think we see behind the renaissance of what’s happening in infrastructure. They go hand in hand. One is the geopolitics of the world right now. Obviously, the world was global flat, and now it’s becoming increasingly siloed, so people are playing it to their own interests. There’s a lot of replication of infrastructure as well because people want to be autonomous, and they want to drive their own ability to serve end consumers, businesses, etc., in terms of data centers and everything else. That ability has led to things like, for example, chips shortage. The fact that there are semiconductors, there are shortages across the board, like memory shortages, where everything is packed up until 2027 of 2028. A lot of the memory that was being produced is already spoken for, which is shocking. There’s obviously generation of supply chain fragilities, obviously, some of it because of policies, for example, in the US with tariffs, etc, security of energy, etc. Then the last force directly linked to the geopolitics is the opposite of it, which is the policy as an accelerant, so to speak, as something that is accelerating development, where because of those silos, individual countries, as part their industrial policy, then want to put capital behind their local ecosystems, their local companies, so that their local companies and their local systems are for sure the winners, or at least, at the very least, serve their own local markets. I think that’s true of a lot of the things we’re seeing, for example, in the US with the Chips Act, for semiconductors, with IGA, IRA, and other elements of what we’ve seen in terms of practices, policies that have been implemented even in Europe, China, and other parts of the world. Bertrand Schmitt Talking about chips shortages, it’s pretty insane what has been happening with memory. Just the past few weeks, I have seen a close to 3X increase in price in memory prices in a matter of weeks. Apparently, it started with a huge order from OpenAI. Apparently, they have tried to corner the memory market. Interestingly enough, it has flat-footed the entire industry, and that includes Google, that includes Microsoft. There are rumours of their teams now having moved to South Korea, so they are closer to the action in terms of memory factories and memory decision-making. There are rumours of execs who got fired because they didn’t prepare for this type of eventuality or didn’t lock in some of the supply chain because that memory was initially for AI, but obviously, it impacts everything because factories making memories, you have to plan years in advance to build memories. You cannot open new lines of manufacturing like this. All factories that are going to open, we know when they are going to open because they’ve been built up for years. There is no extra capacity suddenly. At the very best, you can change a bit your line of production from one type of memory to another type. But that’s probably about it. Nuno Gonçalves Pedro Just to be clear, all these transformations we’re seeing isn’t to say just hardware is back, right? It’s not just hardware. There’s physicality. The buildings are coming back, right? It’s full stack. Software is here. That’s why everything is happening. Policy is here. Finance is here. It’s a little bit like the name of the movie, right? Everything everywhere all at once. Everything’s happening. It was in some ways driven by the upper stacks, by the app layers, by the platform layers. But now we need new infrastructure. We need more infrastructure. We need it very, very quickly. We need it today. We’re already lacking in it. Semiconductors: compute is the new oil Maybe that’s a good segue into the first piece of the whole infrastructure thing that’s driving now the most valuable company in the world, NVIDIA, which is semiconductors. Semiconductors are driving compute. Semis are the foundation of infrastructure as a compute. Everyone needs it for every thing, for every activity, not just for compute, but even for sensors, for actuators, everything else. That’s the beginning of it all. Semiconductor is one of the key pieces around the infrastructure stack that’s being built at scale at this moment in time. Bertrand Schmitt Yes. What’s interesting is that if we look at the market gap of Semis versus software as a service, cloud companies, there has been a widening gap the past year. I forgot the exact numbers, but we were talking about plus 20, 25% for Semis in term of market gap and minus 5, minus 10 for SaaS companies. That’s another trend that’s happening. Why is this happening? One, because semiconductors are core to the AI build-up, you cannot go around without them. But two, it’s also raising a lot of questions about the durability of the SaaS, a software-as-a-service business model. Because if suddenly we have better AI, and that’s all everyone is talking about to justify the investment in AI, that it keeps getting better, and it keeps improving, and it’s going to replace your engineers, your software engineers. Then maybe all of this moat that software companies built up over the years or decades, sometimes, might unravel under the pressure of newly coded, newly built, cheaper alternatives built from the ground up with AI support. It’s not just that, yes, semiconductors are doing great. It’s also as a result of that AI underlying trend that software is doing worse right now. Nuno Gonçalves Pedro At the end of the day, this foundational piece of infrastructure, semiconductor, is obviously getting manifest to many things, fabrication, manufacturing, packaging, materials, equipment. Everything’s being driven, ASML, etc. There are all these different players around the world that are having skyrocket valuations now, it’s because they’re all part of the value chain. Just to be very, very clear, there’s two elements of this that I think are very important for us to remember at this point in time. One, it’s the entire value chains are being shifted. It’s not just the chips that basically lead to computing in the strict sense of it. It’s like chips, for example, that drive, for example, network switching. We’re going to talk about networking a bit, but you need chips to drive better network switching. That’s getting revolutionised as well. For example, we have an investment in that space, a company called the eridu.ai, and they’re revolutionising one of the pieces around that stack. Second part of the puzzle, so obviously, besides the holistic view of the world that’s changing in terms of value change, the second piece of the puzzle is, as we discussed before, there’s industrial policy. We already mentioned the CHIPS Act, which is something, for example, that has been done in the US, which I think is 52 billion in incentives across a variety of things, grants, loans, and other mechanisms to incentivise players to scale capacity quick and to scale capacity locally in the US. One of the effects of that now is obviously we had the TSMC, US expansion with a factory here in the US. We have other levels of expansion going on with Intel, Samsung, and others that are happening as we speak. Again, it’s this two by two. It’s market forces that drive the need for fundamental shifts in the value chain. On the other industrial policy and actual money put forward by states, by governments, by entities that want to revolutionise their own local markets. Bertrand Schmitt Yes. When you talk about networking, it makes me think about what NVIDIA did more than six years ago when they acquired Mellanox. At the time, it was largest acquisition for NVIDIA in 2019, and it was networking for the data center. Not networking across data center, but inside the data center, and basically making sure that your GPUs, the different computers, can talk as fast as possible between each of them. I think that’s one piece of the puzzle that a lot of companies are missing, by the way, about NVIDIA is that they are truly providing full systems. They are not just providing a GPU. Some of their competitors are just providing GPUs. But NVIDIA can provide you the full rack. Now, they move to liquid-cool computing as well. They design their systems with liquid cooling in mind. They have a very different approach in the industry. It’s a systematic system-level approach to how do you optimize your data center. Quite frankly, that’s a bit hard to beat. Nuno Gonçalves Pedro For those listening, you’d be like, this is all very different. Semiconductors, networking, energy, manufacturing, this is all different. Then all of a sudden, as Bertrand is saying, well, there are some players that are acting across the stack. Then you see in the same sentence, you’re talking about nuclear power in Microsoft or nuclear power in Google, and you’re like, what happened? Why are these guys in the same sentence? It’s like they’re tech companies. Why are they talking about energy? It’s the nature of that. These ecosystems need to go hand in hand. The value chains are very deep. For you to actually reap the benefits of more and more, for example, semiconductor availability, you have to have better and better networking connectivity, and you have to have more and more energy at lower and lower costs, and all of that. All these things are intrinsically linked. That’s why you see all these big tech companies working across stack, NVIDIA being a great example of that in trying to create truly a systems approach to the world, as Bertrand was mentioning. Networking & connectivity: digital highways get rebuilt On the networking and connectivity side, as we said, we had a lot of fibre that was put down, etc, but there’s still more build-out needs to be done. 5G in terms of its densification is still happening. We’re now starting to talk, obviously, about 6G. I’m not sure most telcos are very happy about that because they just have been doing all this CapEx and all this deployment into 5G, and now people already started talking about 6G and what’s next. Obviously, data center interconnect is quite important, and all the hubbing that needs to happen around data centers is very, very important. We are seeing a lot movements around connectivity that are particularly important. Network gear and the emergence of players like Broadcom in terms of the semiconductor side of the fence, obviously, Cisco, Juniper, Arista, and others that are very much present in this space. As I said, we made an investment on the semiconductor side of networking as well, realizing that there’s still a lot of bottlenecks happening there. But obviously, the networking and connectivity stack still needs to be built at all levels within the data centers, outside of the data centers in terms of last mile, across the board in terms of fibre. We’re seeing a lot of movements still around the space. It’s what connects everything. At the end of the day, if there’s too much latency in these systems, if the bandwidths are not high enough, then we’re going to have huge bottlenecks that are going to be put at the table by a networking providers. Obviously, that doesn’t help anyone. If there’s a button like anywhere, it doesn’t work. All of this doesn’t work. Bertrand Schmitt Yes. Interestingly enough, I know we said for this episode, we not talk too much about space, but when you talk about 6G, it make me think about, of course, Starlink. That’s really your last mile delivery that’s being built as well. It’s a massive investment. We’re talking about thousands of satellites that are interconnected between each other through laser system. This is changing dramatically how companies can operate, how individuals can operate. For companies, you can have great connectivity from anywhere in the world. For military, it’s the same. For individuals, suddenly, you won’t have dead space, wide zones. This is also a part of changing how we could do things. It’s quite important even in the development of AI because, yes, you can have AI at the edge, but that interconnect to the rest of the system is quite critical. Having that availability of a network link, high-quality network link from anywhere is a great combo. Nuno Gonçalves Pedro Then you start seeing regions of the world that want to differentiate to attract digital nomads by saying, “We have submarine cables that come and hub through us, and therefore, our connectivity is amazing.” I was just in Madeira, and they were talking about that in Portugal. One of the islands of Portugal. We have some Marine cables. You have great connectivity. We’re getting into that discussion where people are like, I don’t care. I mean, I don’t know. I assume I have decent connectivity. People actually care about decent connectivity. This discussion is not just happening at corporate level, at enterprise level? Etc. Even consumers, even people that want to work remotely or be based somewhere else in the world. It’s like, This is important Where is there a great connectivity for me so that I can have access to the services I need? Etc. Everyone becomes aware of everything. We had a cloud flare mishap more recently that the CEO had to jump online and explain deeply, technically and deeply, what happened. Because we’re in their heads. If Cloudflare goes down, there’s a lot of websites that don’t work. All of this, I think, is now becoming du jour rather than just an afterthought. Maybe we’ll think about that in the future. Bertrand Schmitt Totally. I think your life is being changed for network connectivity, so life of individuals, companies. I mean, everything. Look at airlines and ships and cruise ships. Now is the advent of satellite connectivity. It’s dramatically changing our experience. Nuno Gonçalves Pedro Indeed. Energy: rebuilding the power stack (not just renewables) Moving maybe to energy. We’ve talked about energy quite a bit in the past. Maybe we start with the one that we didn’t talk as much, although we did mention it, which was, let’s call it the fossil infrastructure, what’s happening around there. Everyone was saying, it’s all going to be renewables and green. We’ve had a shift of power, geopolitics. Honestly, I the writing was on the wall that we needed a lot more energy creation. It wasn’t either or. We needed other sources to be as efficient as possible. Obviously, we see a lot of work happening around there that many would have thought, Well, all this infrastructure doesn’t matter anymore. Now we’re seeing LNG terminals, pipelines, petrochemical capacity being pushed up, a lot of stuff happening around markets in terms of export, and not only around export, but also around overall distribution and increases and improvements so that there’s less leakage, distribution of energy, etc. In some ways, people say, it’s controversial, but it’s like we don’t have enough energy to spare. We’re already behind, so we need as much as we can. We need to figure out the way to really extract as much as we can from even natural resources, which In many people’s mind, it’s almost like blasphemous to talk about, but it is where we are. Obviously, there’s a lot of renaissance also happening on the fossil infrastructure basis, so to speak. Bertrand Schmitt Personally, I’m ecstatic that there is a renaissance going regarding what is called fossil infrastructure. Oil and gas, it’s critical to humanity well-being. You never had growth of countries without energy growth and nothing else can come close. Nuclear could come close, but it takes decades to deploy. I think it’s great. It’s great for developed economies so that they do better, they can expand faster. It’s great for third-world countries who have no realistic other choice. I really don’t know what happened the past 10, 15 years and why this was suddenly blasphemous. But I’m glad that, strangely, thanks to AI, we are back to a more rational mindset about energy and making sure we get efficient energy where we can. Obviously, nuclear is getting a second act. Nuno Gonçalves Pedro I know you would be. We’ve been talking about for a long time, and you’ve been talking about it in particular for a very long time. Bertrand Schmitt Yes, definitely. It’s been one area of interest of mine for 25 years. I don’t know. I’ve been shocked about what happened in Europe, that willingness destruction of energy infrastructure, especially in Germany. Just a few months ago, they keep destroying on live TV some nuclear station in perfect working condition and replacing them with coal. I’m not sure there is a better definition of insanity at this stage. It looks like it’s only the Germans going that hardcore for some reason, but at least the French have stopped their program of decommissioning. America, it seems to be doing the same, so it’s great. On top of it, there are new generations that could be put to use. The Chinese are building up a very large nuclear reactor program, more than 100 reactors in construction for the next 10 years. I think everybody has to catch up because at some point, this is the most efficient energy solution. Especially if you don’t build crazy constraints around the construction of these nuclear reactors. If we are rational about permits, about energy, about safety, there are great things we could be doing with nuclear. That might be one of the only solution if we want to be competitive, because when energy prices go down like crazy, like in China, they will do once they have reach delivery of their significant build-up of nuclear reactors, we better be ready to have similar options from a cost perspective. Nuno Gonçalves Pedro From the outside, at the very least, nuclear seems to be probably in the energy one of the areas that’s more being innovated at this moment in time. You have startups in the space, you have a lot really money going into it, not just your classic industrial development. That’s very exciting. Moving maybe to the carbonization and what’s happening. The CCUS, and for those who don’t know what it is, carbon capture, utilization, and storage. There’s a lot of stuff happening around that space. That’s the area that deals with the ability to capture CO₂ emissions from industrial sources and/or the atmosphere and preventing their release. There’s a lot of things happening in that space. There’s also a lot of things happening around hydrogen and geothermal and really creating the ability to storage or to store, rather, energy that then can be put back into the grids at the right time. There’s a lot of interesting pieces happening around this. There’s some startup movement in the space. It’s been a long time coming, the reuse of a lot of these industrial sources. Not sure it’s as much on the news as nuclear, and oil and gas, but certainly there’s a lot of exciting things happening there. Bertrand Schmitt I’m a bit more dubious here, but I think geothermal makes sense if it’s available at reasonable price. I don’t think hydrogen technology has proven its value. Concerning carbon capture, I’m not sure how much it’s really going to provide in terms of energy needs, but why not? Nuno Gonçalves Pedro Fuels niche, again, from the outside, we’re not energy experts, but certainly, there are movements in the space. We’ll see what’s happening. One area where there’s definitely a lot of movement is this notion of grid and storage. On the one hand, that transmission needs to be built out. It needs to be better. We’ve had issues of blackouts in the US. We’ve had issues of blackouts all around the world, almost. Portugal as well, for a significant part of the time. The ability to work around transmission lines, transformers, substations, the modernization of some of this infrastructure, and the move forward of it is pretty critical. But at the other end, there’s the edge. Then, on the edge, you have the ability to store. We should have, better mechanisms to store energy that are less leaky in terms of energy storage. Obviously, there’s a lot of movement around that. Some of it driven just by commercial stuff, like Tesla a lot with their storage stuff, etc. Some of it really driven at scale by energy players that have the interest that, for example, some of the storage starts happening closer to the consumption as well. But there’s a lot of exciting things happening in that space, and that is a transformative space. In some ways, the bottleneck of energy is also around transmission and then ultimately the access to energy by homes, by businesses, by industries, etc. Bertrand Schmitt I would say some of the blackout are truly man-made. If I pick on California, for instance. That’s the logical conclusion of the regulatory system in place in California. On one side, you limit price that energy supplier can sell. The utility company can sell, too. On the other side, you force them to decommission the most energy-efficient and least expensive energy source. That means you cap the revenues, you make the cost increase. What is the result? The result is you cannot invest anymore to support a grid and to support transmission. That’s 100% obvious. That’s what happened, at least in many places. The solution is stop crazy regulations that makes no economic sense whatsoever. Then, strangely enough, you can invest again in transmission, in maintenance, and all I love this stuff. Maybe another piece, if we pick in California, if you authorize building construction in areas where fires are easy, that’s also a very costly to support from utility perspective, because then you are creating more risk. You are forced buy the state to connect these new constructions to the grid. You have more maintenance. If it fails, you can create fire. If you create fire, you have to pay billions of fees. I just want to highlight that some of this is not a technological issue, is not per se an investment issue, but it’s simply the result of very bad regulations. I hope that some will learn, and some change will be made so that utilities can do their job better. Nuno Gonçalves Pedro Then last, but not the least, on the energy side, energy is becoming more and more digitally defined in some ways. It’s like the analogy to networks that they’ve become more, and more software defined, where you have, at the edge is things like smart meters. There’s a lot of things you can do around the key elements of the business model, like dynamic pricing and other elements. Demand response, one of the areas that I invested in, I invest in a company called Omconnect that’s now merged with what used to be Google Nest. Where to deploy that ability to do demand response and also pass it to consumers so that consumers can reduce their consumption at times where is the least price effective or the less green or the less good for the energy companies to produce energy. We have other things that are happening, which are interesting. Obviously, we have a lot more electric vehicles in cars, etc. These are also elements of storage. They don’t look like elements of storage, but the car has electricity in it once you charge it. Once it’s charged, what do you do with it? Could you do something else? Like the whole reverse charging piece that we also see now today in mobile devices and other edge devices, so to speak. That also changes the architecture of what we’re seeing around the space. With AI, there’s a lot of elements that change around the value chain. The ability to do forecasting, the ability to have, for example, virtual power plans because of just designated storage out there, etc. Interesting times happening. Not sure all utilities around the world, all energy providers around the world are innovating at the same pace and in the same way. But certainly just looking at the industry and talking to a lot of players that are CEOs of some of these companies. That are leading innovation for some of these companies, there’s definitely a lot more happening now in the last few years than maybe over the last few decades. Very exciting times. Bertrand Schmitt I think there are two interesting points in what you say. Talking about EVs, for instance, a Cybertruck is able to send electricity back to your home if your home is able to receive electricity from that source. Usually, you have some changes to make to the meter system, to your panel. That’s one great way to potentially use your car battery. Another piece of the puzzle is that, strangely enough, most strangely enough, there has been a big push to EV, but at the same time, there has not been a push to provide more electricity. But if you replace cars that use gasoline by electric vehicles that use electricity, you need to deliver more electricity. It doesn’t require a PhD to get that. But, strangely enough, nothing was done. Nuno Gonçalves Pedro Apparently, it does. Bertrand Schmitt I remember that study in France where they say that, if people were all to switch to EV, we will need 10 more nuclear reactors just on the way from Paris to Nice to the Côte d’Azur, the French Rivière, in order to provide electricity to the cars going there during the summer vacation. But I mean, guess what? No nuclear plant is being built along the way. Good luck charging your vehicles. I think that’s another limit that has been happening to the grid is more electric vehicles that require charging when the related infrastructure has not been upgraded to support more. Actually, it has quite the opposite. In many cases, we had situation of nuclear reactors closing down, so other facilities closing down. Obviously, the end result is an increase in price of electricity, at least in some states and countries that have not sold that fully out. Nuno Gonçalves Pedro Manufacturing: the return of “atoms + bits” Moving to manufacturing and what’s happening around manufacturing, manufacturing technology. There’s maybe the case to be made that manufacturing is getting replatformed, right? It’s getting redefined. Some of it is very obvious, and it’s already been ongoing for a couple of decades, which is the advent of and more and more either robotic augmented factories or just fully roboticized factories, where there’s very little presence of human beings. There’s elements of that. There’s the element of software definition on top of it, like simulation. A lot of automation is going on. A lot of AI has been applied to some lines in terms of vision, safety. We have an investment in a company called Sauter Analytics that is very focused on that from the perspective of employees and when they’re still humans in the loop, so to speak, and the ability to really figure out when people are at risk and other elements of what’s happening occurring from that. But there’s more than that. There’s a little bit of a renaissance in and of itself. Factories are, initially, if we go back a couple of decades ago, factories were, and manufacturing was very much defined from the setup. Now it’s difficult to innovate, it’s difficult to shift the line, it’s difficult to change how things are done in the line. With the advent of new factories that have less legacy, that have more flexible systems, not only in terms of software, but also in terms of hardware and robotics, it allows us to, for example, change and shift lines much more easily to different functions, which will hopefully, over time, not only reduce dramatically the cost of production. But also increase dramatically the yield, it increases dramatically the production itself. A lot of cool stuff happening in that space. Bertrand Schmitt It’s exciting to see that. One thing this current administration in the US has been betting on is not just hoping for construction renaissance. Especially on the factory side, up of factories, but their mindset was two things. One, should I force more companies to build locally because it would be cheaper? Two, increase output and supply of energy so that running factories here in the US would be cheaper than anywhere else. Maybe not cheaper than China, but certainly we get is cheaper than Europe. But three, it’s also the belief that thanks to AI, we will be able to have more efficient factories. There is always that question, do Americans to still keep making clothes, for instance, in factories. That used to be the case maybe 50 years ago, but this move to China, this move to Bangladesh, this move to different places. That’s not the goal. But it can make sense that indeed there is ability, thanks to robots and AI, to have more automated factories, and these factories could be run more efficiently, and as a result, it would be priced-competitive, even if run in the US. When you want to think about it, that has been, for instance, the South Korean playbook. More automated factories, robotics, all of this, because that was the only way to compete against China, which has a near infinite or used to have a near infinite supply of cheaper labour. I think that all of this combined can make a lot of sense. In a way, it’s probably creating a perfect storm. Maybe another piece of the puzzle this administration has been working on pretty hard is simplifying all the permitting process. Because a big chunk of the problem is that if your permitting is very complex, very expensive, what take two years to build become four years, five years, 10 years. The investment mass is not the same in that situation. I think that’s a very important part of the puzzle. It’s use this opportunity to reduce regulatory state, make sure that things are more efficient. Also, things are less at risk of bribery and fraud because all these regulations, there might be ways around. I think it’s quite critical to really be careful about this. Maybe last piece of the puzzle is the way accounting works. There are new rules now in 2026 in the US where you can fully depreciate your CapEx much faster than before. That’s a big win for manufacturing in the US. Suddenly, you can depreciate much faster some of your CapEx investment in manufacturing. Nuno Gonçalves Pedro Just going back to a point you made and then moving it forward, even China, with being now probably the country in the world with the highest rate of innovation and take up of industrial robots. Because of demographic issues a little bit what led Japan the first place to be one of the real big innovators around robots in general. The fact that demographics, you’re having an aging population, less and less children. How are you going to replace all these people? Moving that into big winners, who becomes a big winner in a space where manufacturing is fundamentally changing? Obviously, there’s the big four of robots, which is ABB, FANUC, KUKA, and Yaskawa. Epson, I think, is now in there, although it’s not considered one of the big four. Kawasaki, Denso, Universal Robots. There’s a really big robotics, industrial robotic companies in the space from different origins, FANUC and Yaskawa, and Epson from Japan, KUKA from Germany, ABB from Switzerland, Sweden. A lot of now emerging companies from China, and what’s happening in that space is quite interesting. On the other hand, also, other winners will include players that will be integrators that will build some of the rest of the infrastructure that goes into manufacturing, the Siemens of the world, the Schneider’s, the Rockwell’s that will lead to fundamental industrial automation. Some big winners in there that whose names are well known, so probably not a huge amount of surprises there. There’s movements. As I said, we’re still going to see the big Chinese players emerging in the world. There are startups that are innovating around a lot of the edges that are significant in this space. We’ll see if this is a space that will just be continued to be dominated by the big foreign robotics and by a couple of others and by the big integrators or not. Bertrand Schmitt I think you are right to remind about China because China has been moving very fast in robotics. Some Chinese companies are world-class in their use of robotics. You have this strange mix of some older industries where robotics might not be so much put to use and typically state-owned, versus some private companies, typically some tech companies that are reconverting into hardware in some situation. That went all in terms of robotics use and their demonstrations, an example of what’s happening in China. Definitely, the Chinese are not resting. Everyone smart enough is playing that game from the Americans, the Chinese, Japanese, the South Koreans. Nuno Gonçalves Pedro Exciting things are manufacturing, and maybe to bring it all together, what does it mean for all the big players out there? If we talk with startups and talk about startups, we didn’t mention a ton of startups today, right? Maybe incumbent wind across the board. But on a more serious note, we did mention a few. For example, in nuclear energy, there’s a lot of startups that have been, some of them, incredibly well-funded at this moment in time. Wrap: what it means for startups, incumbents, and investors There might be some big disruptions that will come out of startups, for example, in that space. On the chipset side, we talked about the big gorillas, the NVIDIAs, AMDs, Intel, etc., of the world. But we didn’t quite talk about the fact that there’s a lot of innovation, again, happening on the edges with new players going after very large niches, be it in networking and switching. Be it in compute and other areas that will need different, more specialized solutions. Potentially in terms of compute or in terms of semiconductor deployments. I think there’s still some opportunities there, maybe not to be the winner takes all thing, but certainly around a lot of very significant niches that might grow very fast. Manufacturing, we mentioned the same. Some of the incumbents seem to be in the driving seat. We’ll see what happens if some startups will come in and take some of the momentum there, probably less likely. There are spaces where the value chains are very tightly built around the OEMs and then the suppliers overall, classically the tier one suppliers across value chains. Maybe there is some startup investment play. We certainly have played in the couple of the spaces. I mentioned already some of them today, but this is maybe where the incumbents have it all to lose. It’s more for them to lose rather than for the startups to win just because of the scale of what needs to be done and what needs to be deployed. Bertrand Schmitt I know. That’s interesting point. I think some players in energy production, for instance, are moving very fast and behaving not only like startups. Usually, it’s independent energy suppliers who are not kept by too much regulations that get moved faster. Utility companies, as we just discussed, have more constraints. I would like to say that if you take semiconductor space, there has been quite a lot of startup activities way more than usual, and there have been some incredible success. Just a few weeks ago, Rock got more or less acquired. Now, you have to play games. It’s not an outright acquisition, but $20 billion for an IP licensing agreement that’s close to an acquisition. That’s an incredible success for a company. Started maybe 10 years ago. You have another Cerebras, one of the competitor valued, I believe, quite a lot in similar range. I think there is definitely some activity. It’s definitely a different game compared to your software startup in terms of investment. But as we have seen with AI in general, the need for investment might be larger these days. Yes, it might be either traditional players if they can move fast enough, to be frank, because some of them, when you have decades of being run as a slow-moving company, it’s hard to change things. At the same time, it looks like VCs are getting bigger. Wall Street is getting more ready to finance some of these companies. I think there will be opportunities for startups, but definitely different types of startups in terms of profile. Nuno Gonçalves Pedro Exactly. From an investor standpoint, I think on the VC side, at least our core belief is that it’s more niche. It’s more around big niches that need to be fundamentally disrupted or solutions that require fundamental interoperability and integration where the incumbents have no motivation to do it. Things that are a little bit more either packaging on the semiconductor side or other elements of actual interoperability. Even at the software layer side that feeds into infrastructure. If you’re a growth investor, a private equity investor, there’s other plays that are available to you. A lot of these projects need to be funded and need to be scaled. Now we’re seeing projects being funded even for a very large, we mentioned it in one of the previous episodes, for a very large tech companies. When Meta, for example, is going to the market to get funding for data centers, etc. There’s projects to be funded there because just the quantum and scale of some of these projects, either because of financial interest for specifically the tech companies or for other reasons, but they need to be funded by the market. There’s other place right now, certainly if you’re a larger private equity growth investor, and you want to come into the market and do projects. Even public-private financing is now available for a lot of things. Definitely, there’s a lot of things emanating that require a lot of funding, even for large-scale projects. Which means the advent of some of these projects and where realization is hopefully more of a given than in other circumstances, because there’s actual commercial capital behind it and private capital behind it to fuel it as well, not just industrial policy and money from governments. Bertrand Schmitt There was this quite incredible stat. I guess everyone heard about that incredible growth in GDP in Q3 in the US at 4.4%. Apparently, half of that growth, so around 2.2% point, has been coming from AI and related infrastructure investment. That’s pretty massive. Half of your GDP growth coming from something that was not there three years ago or there, but not at this intensity of investment. That’s the numbers we are talking about. I’m hearing that there is a good chance that in 2026, we’re talking about five, even potentially 6% GDP growth. Again, half of it potentially coming from AI and all the related infrastructure growth that’s coming with AI. As a conclusion for this episode on infrastructure, as we just said, it’s not just AI, it’s a whole stack, and it’s manufacturing in general as well. Definitely in the US, in China, there is a lot going on. As we have seen, computing needs connectivity, networks, need power, energy and grid, and all of this needs production capacity and manufacturing. Manufacturing can benefit from AI as well. That way the loop is fully going back on itself. Infrastructure is the next big thing. It’s an opportunity, probably more for incumbents, but certainly, as usual, with such big growth opportunities for startups as well. Thank you, Nuno. Nuno Gonçalves Pedro Thank you, Bertrand.

Atombeam CEO Charles Yeomans joins Chris Lustrino to break down a deceptively simple idea with massive implications: make data smaller while it's streaming so you can move and process more of it—without upgrading networks.Charles explains Atombeam's commercial product NeurPack, how it can often quadruple effective bandwidth, and why this matters across IoT, smart meters, satellites, defense, oil & gas wells, fintech, and eventually data centers and GPU utilization. They also dig into the realities of commercialization—choosing near-term deals that close fast while still pursuing multi-year “industry standard” opportunities—and why execution (not invention) is the real differentiator.00:00 What Atombeam does (pizza analogy)03:13 NeurPack explained05:35 Why 95% of IoT data doesn't move09:38 “Like launching 3 more satellites”13:57 Commercialization + customers16:31 Data centers + GPU utilization24:29 Defense traction + partnerships26:44 What success looks like (distribution)

Está no ar, o Data Hackers News !! Os assuntos mais quentes da semana, com as principais notícias da área de Dados, IA e Tecnologia, que você também encontra na nossa Newsletter semanal, agora no Podcast do Data Hackers !!Aperte o play e ouça agora, o Data Hackers News dessa semana !Para saber tudo sobre o que está acontecendo na área de dados, se inscreva na Newsletter semanal:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.datahackers.news/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Conheça nossos comentaristas do Data Hackers News:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Monique Femme⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Demais canais do Data Hackers:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Site⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Linkedin⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Tik Tok⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠You Tube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Graphics processing units (GPUs) have become the most important commodity in the AI boom — and have made Nvidia a multi-trillion dollar company. But the tensor processing unit (TPU) could present itself as competition for the GPU.TPUs are developed by Google specifically for AI workloads. And so far, Anthropic, OpenAI and Meta have reportedly made deals for Google's TPUs.Christopher Miller, historian at Tufts University and author of "Chip War: The Fight for the World's Most Critical Technology," explains what this could mean.

Graphics processing units (GPUs) have become the most important commodity in the AI boom — and have made Nvidia a multi-trillion dollar company. But the tensor processing unit (TPU) could present itself as competition for the GPU.TPUs are developed by Google specifically for AI workloads. And so far, Anthropic, OpenAI and Meta have reportedly made deals for Google's TPUs.Christopher Miller, historian at Tufts University and author of "Chip War: The Fight for the World's Most Critical Technology," explains what this could mean.

Varun Sivaram is Founder and CEO of Emerald AI, a company building software that makes AI data centers power flexible. As AI data centers become one of the fastest-growing sources of electricity demand, grid constraints are emerging as a critical bottleneck for compute deployment.In this episode, the conversation focuses on why power availability — not GPUs — is increasingly the limiting factor for AI. Data centers concentrate massive electrical loads in specific locations, creating grid stress, long interconnection delays, and rising electricity costs for surrounding communities. Traditional grid expansion alone is too slow to meet near-term AI demand.Emerald AI's response is to treat AI data centers as flexible loads rather than fixed ones. Its software coordinates compute with grid conditions by shifting workloads across time, geography, and on-site energy resources like batteries. The episode walks through real-world demonstrations, including a published field trial showing a 25% power reduction during grid stress without breaking compute performance. The discussion frames flexible load as one of the fastest ways to unlock power for AI while improving grid stability.Episode recorded on Feb 2, 2026 (Published on Feb 10, 2026)In this episode, we cover:(0:00) Intro(1:36) What Emerald AI is and how it works(6:41) Varun's background and why he founded Emerald(10:59) Emerald's software for power-flexible data centers(19:04) The three types of flexibility: temporal, spatial, and resource(23:29) How much control customers give Emerald(28:20) Coordinating compute with on-site energy like batteries(31:27) Off-grid vs. grid-connected data centers(35:39) Why exiting the grid creates political and systemic risk(37:12) Emerald AI's open rolesLinks:Varun Sivaram on LinkedIn: https://www.linkedin.com/in/varunsivaramEmerald AI: https://www.emeraldai.co/AI data centers as grid-interactive assets paper Enjoyed this episode? Please leave us a review! Share feedback or suggest future topics and guests at info@mcj.vc.Connect with MCJ:Cody Simms on LinkedInVisit mcj.vcSubscribe to the MCJ Newsletter*Editing and post-production work for this episode was provided by The Podcast Consultant

Join The Full Nerd gang as they talk about the latest PC building news. In this episode the gang is joined by Dr. Ian Cutress of  @TechTechPotato  fame to talk about how everyone has the "partnership" between Intel and Nvidia wrong, what the yields from 18A can tell us, updates for the RAM crisis and more. And of course we answer questions live! Links: - Intel + Nvidia partnership: https://youtu.be/v7_D9UBh6rk?si=ghzv719_Si23J4jD - Nvidia cutting consumer GPUs: https://www.pcworld.com/article/3054899/nvidia-is-reportedly-skipping-consumer-gpus-in-2026-thanks-ai.html - 18A yields: https://www.pcworld.com/article/3040560/intel-now-faces-a-chip-shortage-at-the-worst-possible-time.html Join the PC related discussions and ask us questions on Discord: https://discord.gg/UWhjwg778a Follow the crew on X and Bluesky: @AdamPMurray @BradChacos @MorphingBall @WillSmith 00:00 - Intro 04:55 - Ram pricing 40:48 - Nvidia/Intel partnership 1:14:54 - 18a yields 1:30:23 - Q&A Learn more about your ad choices. Visit megaphone.fm/adchoices

The Six Five Pod is back with Episode 291. Daniel Newman and Patrick Moorhead are fresh off trips to Davos and Abu Dhabi, where they've explored the full AI stack up close (models, infrastructure, healthcare/genomics). This episode dives into what really matters right now in the markets and tech. From Microsoft's Maia 200 inference push, to NVIDIA's $2B CoreWeave bet, OpenAI's Codex closing the coding gap, the "SaaSpocalypse" panic, Cisco's AI Summit, and a no-BS debate on whether AI agents are actually enterprise-ready. The handpicked topics for this week are: Inside Abu Dhabi's Full-Stack AI Play: From universities to healthcare to hyperscale infrastructure — Pat shares a firsthand perspective on how the UAE is quietly building an end-to-end AI ecosystem. Optics, Cooling, and the Hidden AI Infrastructure Layer: Why companies like Coherent matter as much as GPUs — and how photonics, co-packaged optics, and rack-level cooling are becoming critical to scaling AI factories. Inference Takes Center Stage: Microsoft's Maia 200 shows real progress — and why hyperscalers are building custom silicon to boost capacity, economics, and control. NVIDIA's $2B CoreWeave Bet Circular finance or strategic genius? We unpack what NVIDIA's latest investment signals about AI factories, cloud capacity, and long-term infrastructure buildout. Codex vs. Claude: The Coding Wars Heat Up: OpenAI closes the gap fast — and developers start hopping between tools as AI coding becomes a moving target. The "SaaSpocalypse" Narrative: Is software really dead? We separate market panic from reality — and explain why SaaS won't disappear, but will never be valued the same again. Cisco's AI Summit Reality Check: From hype to execution: what stood out from Cisco's AI Summit and why networking, security, and enterprise integration matter more than demos. Are AI Agents Enterprise-Ready? The Flip Debates: real-world workflows vs. reliability, governance, and security — where agents work today, and where they still fall short. Big Tech Earnings Whiplash: AWS, Google, Microsoft, Meta, NVIDIA, AMD, Palantir, and Coherent — massive CapEx, cloud acceleration, and what Wall Street is getting wrong about AI ROI.   Be sure to subscribe to The Six Five Pod so you never miss an episode.

In this episode, Alex Rawlings is joined by Alex Sabel, Vice President at THL Partners, to explore how the firm is embracing AI across its operations and portfolio. Alex leads THL's research function and AI strategy, bringing a data-driven, quant mindset to private equity.He shares how THL uses AI internally to improve investment workflows, how portfolio companies are deploying AI to drive product innovation and efficiency, and what he's learned from both successes and failures. Whether you're exploring AI adoption or refining your strategy, this episode offers clear, practical insights from the front lines.⏱ Timestamps00:00 – Intro to Alex Sabel & THL's AI FocusAI at the firm, portfolio, and personal level.00:55 – Alex's BackgroundFrom public markets to PE, building THL's research and AI function.03:12 – Common Mistakes in AI AdoptionWhy firms must focus on data foundations first.04:35 – Real-Time Insight vs. Info OverloadThe value of surfacing insights at the right time.06:02 – Investing in the Global Compute EcosystemTHL's thesis: look beyond GPUs to second-order AI winners.09:19 – THL's Three-Pronged AI StrategyInvest in AI, use it internally, and support portfolio adoption.11:42 – How THL Supports Portfolio InnovationRoundtables, tech summits, and a vendor ecosystem to foster AI experimentation.13:36 – Case Studies: Binder, FourKites & SentriaExamples of AI-driven product innovation and operational efficiency.17:57 – When AI FailsWhy THL embraces “fail fast” and knows when to build vs. buy.22:12 – Deciding When to Use AIBreak problems into first principles—GenAI isn't always the answer.25:26 – What's Blown Alex's MindAI organizing and standardizing messy, fragmented enterprise data.27:45 – Daily Tools & TipsCoding assistants and using multiple LLMs (ChatGPT, Claude, Gemini, Groq) for varied insights.31:06 – What to ReadShort term: WSJ, FT, Economist.Deep dives: SemiAnalysis and top Substacks.32:31 – Connect with Alex SabelOpen to collaborating on AI, compute infrastructure, and emerging vendors.Raw Selection partners with Private Equity firms and their portfolio companies to secure exceptional executive talent. We focus on de-risking executive recruitment through meticulous search and selection processes, ensuring top-tier performance and long-term success.

- Sovereign AI: what is it, and does anyone have it? - Bullish on Eviden: Europe's top system company restores old name - Intel to build server GPUs of its own - MIT Technology Review AI Predictions [audio mp3="https://orionx.net/wp-content/uploads/2026/02/HPCNB_20260209.mp3"][/audio] The post HPC News Bytes – 20260209 appeared first on OrionX.net.

David Choi and Conor Moore are CoFounders of Permian Labs, the builders behind USDai.AI infrastructure is projecting trillions of dollars in CapEx spend, but there's a problem: traditional finance can't keep up. Banks move too slow. Private credit funds can't scale. The most important commodity in the world has no liquid debt market.USDai is filling this gap by financing AI infrastructure with GPU-backed loans, offering stablecoin depositors 10-15% APR. David and Conor break down how they're using DeFi rails and tokenization to create liquid debt markets for GPUs, enabling institutional borrowers to access capital and retail users to earn yield on productive AI infrastructure.In this episode, we cover:+ Why trillions in AI CapEx can't get traditional financing+ How USDAI structures loans against GPUs, not businesses+ Why this could become "the interest rate of artificial intelligence"+ Their two-token model: USDai vs. sUSDai------

Black Box Problem... Oh you mean like Saturn? Is this an admission that "AI" was rediscovered and rebuilt rather than a new concept?Many thanks for the channel campaign help. We're still a ways away from the goal. See the links below to help get the stuff we need. Thank You!Use Code BB5 here: https://SemperFryLLC.comClick Picture on the Right for the AZURE WELL products and use code BB5 for your discount.Find clickable portals to Dr Monzo and Dr Glidden on Dan's site, and it's the home of the best hot sauce, his book, and Clean Source Creatine-HCL.Join Dr. Glidden's Membership site here:https://leavebigpharmabehind.com/?via=pgndhealth⁠Code: baalbusters for 25% OFFMake Dr. Glidden Your DoctorPods & Exclusives AD-FREE!https://patreon.com/c/KristosCasthttps://buymeacoffee.com/BaalBustershttps://paypal.me/BaalBustershttps://GiveSendGo.com/BaalBustersTwitter Account: https://x.com/KristosCasthttps://open.spotify.com/show/0vtEmTteIzD2nB5bdQ8qDRWant Dan's book or his Award winning hot sauces and spicy honey?Go here: https://SemperFryLLC.comBooks and Documentaries You Should Own: https://www.bannedbyamazon.com/Use Code: BBDan for 10% OffFind clickable portals to Dr Monzo and Dr Glidden on Dan's site.Subscribe to the NEW dedicated channel for Dr Glidden's Health Solutions Show https://rumble.com/c/DrGliddenHealthShowBecome a supporter of this podcast: https://www.spreaker.com/podcast/ba-al-busters-broadcast--5100262/support.

This Week In Startups is made possible by:Crusoe Cloud - https://crusoe.ai/savingsLemon IO - https://Lemon.io/twistNorthwest Registered Agent - https://www.northwestregisteredagent.com/twistThanks to our guests:Alex Cheema of ExoLabs http://exolabs.netRyan Yanneli of NextVisit https://nextvisit.ai/Today's show: It's the Age of Ultron at TWiST and LAUNCH. We've given our OpenClaw digital Replicants the keys to all of our systems and we're seeing how much of our jobs they can really do when left to their own devices.Producer Oliver stops by the show to give us a peek behind the curtain, at the new control panel and dashboard OpenClaw built FOR ITSELF (with a bit of human assistance).PLUS we're joined by Alex Cheema of ExoLabs. His company helps everyday consumers run powerful frontier LLMs on their own devices, essential to protect your data and personalize your AI experience.ALSO congratulations to Ryan Yanneli from NextVisit on winning our Gamma Pitch Deck Competition! He walks away with $25K from LAUNCH and our friends at Gamma.Timestamps:(00:00) Introducing Alex Cheema to the show(3:17) Why it is so important to run AI on local hardware(6:58) Using OpenClaw Producer to automate TWiST(8:59) How to Train your AI(11:58) What is a Chron Job? (Hint: chron means chronological)(13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.(17:53) OpenClaw managing the LAUNCH/TWiST team(19:54)  Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(20:58) Turning AI into Ultron, self optimization(27:21) The Future: frontier models: running on your Iphone!(28:37) Prompt injections: how people can hack your OpenClaw(30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twist(31:31) OpenClaw invites guests that join the show(40:29) Oliver shows off OpenClaw mission control dashboard(46:30) Stacking Apple Silicon vs. Running Kimi-K(50:18) How Exo Labs works — stringing together Mac Silicon(54:29) Ryan from Nextvisit wins Gamma Pitch Competition(59:10) Industry Season 4 reflects tech regulation*Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcp*Follow Lon:X: https://x.com/lons*Follow Alex:X: https://x.com/alexLinkedIn: https://www.linkedin.com/in/alexwilhelm/*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis/*Thank you to our partners:(13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.(19:54)  Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twistCheck out all our partner offers: https://partners.launch.co/

Cheeky Pint: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- John Collison and Dwarkesh Patel sit down with Elon Musk to discuss why the future of AI isn't on Earth, but in the "always sunny" vacuum of space. Between pints, they discuss the brutal physics of scaling—from the "farcically cheap" solar cells coming out of China to switching Starship from carbon fiber to stainless steel—as well as the “infinite money glitch” of humanoid robots, China, and DOGE.Timestamps00:00:23 Space GPUs00:35:39 Alignment00:58:48 xAI01:15:01 Optimus01:28:03 China01:40:46 Management02:16:38 DOGE02:34:58 Space GPUs redux

  Go to the patreon for AD-Free podcasts and exclusives including the Sunna Wr'alda Solar University about to launch that is a deprogramming and restorative initiative.  There I will go over the true history of mankind and civilization dating back over 5,000 years ago, and how the nefarious mythmongers and deceptive moon cult had poisoned our heritage and history whe compiling their inverse biblical writings.  We are restoring our true religion under the Sun.  AND I am your pastor.    AI Data Centers may not have anything at all to do with AI. I'm familiar with the fake consumer grade AI LLMs and their complete difference with the assumed military weapon grade AI they are said to possess to bring mankid to its knees. But what if that was all or half BULLSHT? These data centers require the consumption of countless GPUs, and that is where th clues may lie. What if these data centers are being constructed to create an artificial REALITY impossible to distinguish from the "real" world and possibly even favorable for some to that of the natural? Is this really a race to create a system of such high-level illusion, magick trickery, that it ensnares us all? Lots of GPUs working together. Lots of graphics power the likes of which we can't imagine. Is this really about Artificial Intelligence, or is it about Artificial Reality and holographic imprisonment? Consider a vast computer system generating a plausible, artificial reality that captures all of mankind within its illusion. You will own nothing and be happy...Many thanks for the channel campaign help. We're still a ways away from the goal. See the links below to help get the stuff we need. Thank You!Pods & Exclusives AD-FREE!https://patreon.com/c/KristosCasthttps://buymeacoffee.com/BaalBustershttps://paypal.me/BaalBustershttps://GiveSendGo.com/BaalBustersTwitter Account: https://x.com/KristosCasthttps://open.spotify.com/show/0vtEmTteIzD2nB5bdQ8qDRWant Dan's book or his Award winning hot sauces and spicy honey?Go here: https://SemperFryLLC.comBooks and Documentaries You Should Own: https://www.bannedbyamazon.com/Use Code: BBDan for 10% OffUse Code BB5 here: https://SemperFryLLC.comClick Picture on the Right for the AZURE WELL products and use code BB5 for your discount.Find clickable portals to Dr Monzo and Dr Glidden on Dan's siteBecome a supporter of this podcast: https://www.spreaker.com/podcast/ba-al-busters-broadcast--5100262/support.

From Palantir and Two Sigma to building Goodfire into the poster-child for actionable mechanistic interpretability, Mark Bissell (Member of Technical Staff) and Myra Deng (Head of Product) are trying to turn “peeking inside the model” into a repeatable production workflow by shipping APIs, landing real enterprise deployments, and now scaling the bet with a recent $150M Series B funding round at a $1.25B valuation.In this episode, we go far beyond the usual “SAEs are cool” take. We talk about Goodfire's core bet: that the AI lifecycle is still fundamentally broken because the only reliable control we have is data and we post-train, RLHF, and fine-tune by “slurping supervision through a straw,” hoping the model picks up the right behaviors while quietly absorbing the wrong ones. Goodfire's answer is to build a bi-directional interface between humans and models: read what's happening inside, edit it surgically, and eventually use interpretability during training so customization isn't just brute-force guesswork.Mark and Myra walk through what that looks like when you stop treating interpretability like a lab demo and start treating it like infrastructure: lightweight probes that add near-zero latency, token-level safety filters that can run at inference time, and interpretability workflows that survive messy constraints (multilingual inputs, synthetic→real transfer, regulated domains, no access to sensitive data). We also get a live window into what “frontier-scale interp” means operationally (i.e. steering a trillion-parameter model in real time by targeting internal features) plus why the same tooling generalizes cleanly from language models to genomics, medical imaging, and “pixel-space” world models.We discuss:* Myra + Mark's path: Palantir (health systems, forward-deployed engineering) → Goodfire early team; Two Sigma → Head of Product, translating frontier interpretability research into a platform and real-world deployments* What “interpretability” actually means in practice: not just post-hoc poking, but a broader “science of deep learning” approach across the full AI lifecycle (data curation → post-training → internal representations → model design)* Why post-training is the first big wedge: “surgical edits” for unintended behaviors likereward hacking, sycophancy, noise learned during customization plus the dream of targeted unlearning and bias removal without wrecking capabilities* SAEs vs probes in the real world: why SAE feature spaces sometimes underperform classifiers trained on raw activations for downstream detection tasks (hallucination, harmful intent, PII), and what that implies about “clean concept spaces”* Rakuten in production: deploying interpretability-based token-level PII detection at inference time to prevent routing private data to downstream providers plus the gnarly constraints: no training on real customer PII, synthetic→real transfer, English + Japanese, and tokenization quirks* Why interp can be operationally cheaper than LLM-judge guardrails: probes are lightweight, low-latency, and don't require hosting a second large model in the loop* Real-time steering at frontier scale: a demo of steering Kimi K2 (~1T params) live and finding features via SAE pipelines, auto-labeling via LLMs, and toggling a “Gen-Z slang” feature across multiple layers without breaking tool use* Hallucinations as an internal signal: the case that models have latent uncertainty / “user-pleasing” circuitry you can detect and potentially mitigate more directly than black-box methods* Steering vs prompting: the emerging view that activation steering and in-context learning are more closely connected than people think, including work mapping between the two (even for jailbreak-style behaviors)* Interpretability for science: using the same tooling across domains (genomics, medical imaging, materials) to debug spurious correlations and extract new knowledge up to and including early biomarker discovery work with major partners* World models + “pixel-space” interpretability: why vision/video models make concepts easier to see, how that accelerates the feedback loop, and why robotics/world-model partners are especially interesting design partners* The north star: moving from “data in, weights out” to intentional model design where experts can impart goals and constraints directly, not just via reward signals and brute-force post-training—Goodfire AI* Website: https://goodfire.ai* LinkedIn: https://www.linkedin.com/company/goodfire-ai/* X: https://x.com/GoodfireAIMyra Deng* Website: https://myradeng.com/* LinkedIn: https://www.linkedin.com/in/myra-deng/* X: https://x.com/myra_dengMark Bissell* LinkedIn: https://www.linkedin.com/in/mark-bissell/* X: https://x.com/MarkMBissellFull Video EpisodeTimestamps00:00:00 Introduction00:00:05 Introduction to the Latent Space Podcast and Guests from Goodfire00:00:29 What is Goodfire? Mission and Focus on Interpretability00:01:01 Goodfire's Practical Approach to Interpretability00:01:37 Goodfire's Series B Fundraise Announcement00:02:04 Backgrounds of Mark and Myra from Goodfire00:02:51 Team Structure and Roles at Goodfire00:05:13 What is Interpretability? Definitions and Techniques00:05:30 Understanding Errors00:07:29 Post-training vs. Pre-training Interpretability Applications00:08:51 Using Interpretability to Remove Unwanted Behaviors00:10:09 Grokking, Double Descent, and Generalization in Models00:10:15 404 Not Found Explained00:12:06 Subliminal Learning and Hidden Biases in Models00:14:07 How Goodfire Chooses Research Directions and Projects00:15:00 Troubleshooting Errors00:16:04 Limitations of SAEs and Probes in Interpretability00:18:14 Rakuten Case Study: Production Deployment of Interpretability00:20:45 Conclusion00:21:12 Efficiency Benefits of Interpretability Techniques00:21:26 Live Demo: Real-Time Steering in a Trillion Parameter Model00:25:15 How Steering Features are Identified and Labeled00:26:51 Detecting and Mitigating Hallucinations Using Interpretability00:31:20 Equivalence of Activation Steering and Prompting00:34:06 Comparing Steering with Fine-Tuning and LoRA Techniques00:36:04 Model Design and the Future of Intentional AI Development00:38:09 Getting Started in Mechinterp: Resources, Programs, and Open Problems00:40:51 Industry Applications and the Rise of Mechinterp in Practice00:41:39 Interpretability for Code Models and Real-World Usage00:43:07 Making Steering Useful for More Than Stylistic Edits00:46:17 Applying Interpretability to Healthcare and Scientific Discovery00:49:15 Why Interpretability is Crucial in High-Stakes Domains like Healthcare00:52:03 Call for Design Partners Across Domains00:54:18 Interest in World Models and Visual Interpretability00:57:22 Sci-Fi Inspiration: Ted Chiang and Interpretability01:00:14 Interpretability, Safety, and Alignment Perspectives01:04:27 Weak-to-Strong Generalization and Future Alignment Challenges01:05:38 Final Thoughts and Hiring/Collaboration Opportunities at GoodfireTranscriptShawn Wang [00:00:05]: So welcome to the Latent Space pod. We're back in the studio with our special MechInterp co-host, Vibhu. Welcome. Mochi, Mochi's special co-host. And Mochi, the mechanistic interpretability doggo. We have with us Mark and Myra from Goodfire. Welcome. Thanks for having us on. Maybe we can sort of introduce Goodfire and then introduce you guys. How do you introduce Goodfire today?Myra Deng [00:00:29]: Yeah, it's a great question. So Goodfire, we like to say, is an AI research lab that focuses on using interpretability to understand, learn from, and design AI models. And we really believe that interpretability will unlock the new generation, next frontier of safe and powerful AI models. That's our description right now, and I'm excited to dive more into the work we're doing to make that happen.Shawn Wang [00:00:55]: Yeah. And there's always like the official description. Is there an understatement? Is there an unofficial one that sort of resonates more with a different audience?Mark Bissell [00:01:01]: Well, being an AI research lab that's focused on interpretability, there's obviously a lot of people have a lot that they think about when they think of interpretability. And I think we have a pretty broad definition of what that means and the types of places that can be applied. And in particular, applying it in production scenarios, in high stakes industries, and really taking it sort of from the research world into the real world. Which, you know. It's a new field, so that hasn't been done all that much. And we're excited about actually seeing that sort of put into practice.Shawn Wang [00:01:37]: Yeah, I would say it wasn't too long ago that Anthopic was like still putting out like toy models or superposition and that kind of stuff. And I wouldn't have pegged it to be this far along. When you and I talked at NeurIPS, you were talking a little bit about your production use cases and your customers. And then not to bury the lead, today we're also announcing the fundraise, your Series B. $150 million. $150 million at a 1.25B valuation. Congrats, Unicorn.Mark Bissell [00:02:02]: Thank you. Yeah, no, things move fast.Shawn Wang [00:02:04]: We were talking to you in December and already some big updates since then. Let's dive, I guess, into a bit of your backgrounds as well. Mark, you were at Palantir working on health stuff, which is really interesting because the Goodfire has some interesting like health use cases. I don't know how related they are in practice.Mark Bissell [00:02:22]: Yeah, not super related, but I don't know. It was helpful context to know what it's like. Just to work. Just to work with health systems and generally in that domain. Yeah.Shawn Wang [00:02:32]: And Mara, you were at Two Sigma, which actually I was also at Two Sigma back in the day. Wow, nice.Myra Deng [00:02:37]: Did we overlap at all?Shawn Wang [00:02:38]: No, this is when I was briefly a software engineer before I became a sort of developer relations person. And now you're head of product. What are your sort of respective roles, just to introduce people to like what all gets done in Goodfire?Mark Bissell [00:02:51]: Yeah, prior to Goodfire, I was at Palantir for about three years as a forward deployed engineer, now a hot term. Wasn't always that way. And as a technical lead on the health care team and at Goodfire, I'm a member of the technical staff. And honestly, that I think is about as specific as like as as I could describe myself because I've worked on a range of things. And, you know, it's it's a fun time to be at a team that's still reasonably small. I think when I joined one of the first like ten employees, now we're above 40, but still, it looks like there's always a mix of research and engineering and product and all of the above. That needs to get done. And I think everyone across the team is, you know, pretty, pretty switch hitter in the roles they do. So I think you've seen some of the stuff that I worked on related to image models, which was sort of like a research demo. More recently, I've been working on our scientific discovery team with some of our life sciences partners, but then also building out our core platform for more of like flexing some of the kind of MLE and developer skills as well.Shawn Wang [00:03:53]: Very generalist. And you also had like a very like a founding engineer type role.Myra Deng [00:03:58]: Yeah, yeah.Shawn Wang [00:03:59]: So I also started as I still am a member of technical staff, did a wide range of things from the very beginning, including like finding our office space and all of this, which is we both we both visited when you had that open house thing. It was really nice.Myra Deng [00:04:13]: Thank you. Thank you. Yeah. Plug to come visit our office.Shawn Wang [00:04:15]: It looked like it was like 200 people. It has room for 200 people. But you guys are like 10.Myra Deng [00:04:22]: For a while, it was very empty. But yeah, like like Mark, I spend. A lot of my time as as head of product, I think product is a bit of a weird role these days, but a lot of it is thinking about how do we take our frontier research and really apply it to the most important real world problems and how does that then translate into a platform that's repeatable or a product and working across, you know, the engineering and research teams to make that happen and also communicating to the world? Like, what is interpretability? What is it used for? What is it good for? Why is it so important? All of these things are part of my day-to-day as well.Shawn Wang [00:05:01]: I love like what is things because that's a very crisp like starting point for people like coming to a field. They all do a fun thing. Vibhu, why don't you want to try tackling what is interpretability and then they can correct us.Vibhu Sapra [00:05:13]: Okay, great. So I think like one, just to kick off, it's a very interesting role to be head of product, right? Because you guys, at least as a lab, you're more of an applied interp lab, right? Which is pretty different than just normal interp, like a lot of background research. But yeah. You guys actually ship an API to try these things. You have Ember, you have products around it, which not many do. Okay. What is interp? So basically you're trying to have an understanding of what's going on in model, like in the model, in the internal. So different approaches to do that. You can do probing, SAEs, transcoders, all this stuff. But basically you have an, you have a hypothesis. You have something that you want to learn about what's happening in a model internals. And then you're trying to solve that from there. You can do stuff like you can, you know, you can do activation mapping. You can try to do steering. There's a lot of stuff that you can do, but the key question is, you know, from input to output, we want to have a better understanding of what's happening and, you know, how can we, how can we adjust what's happening on the model internals? How'd I do?Mark Bissell [00:06:12]: That was really good. I think that was great. I think it's also a, it's kind of a minefield of a, if you ask 50 people who quote unquote work in interp, like what is interpretability, you'll probably get 50 different answers. And. Yeah. To some extent also like where, where good fire sits in the space. I think that we're an AI research company above all else. And interpretability is a, is a set of methods that we think are really useful and worth kind of specializing in, in order to accomplish the goals we want to accomplish. But I think we also sort of see some of the goals as even more broader as, as almost like the science of deep learning and just taking a not black box approach to kind of any part of the like AI development life cycle, whether that. That means using interp for like data curation while you're training your model or for understanding what happened during post-training or for the, you know, understanding activations and sort of internal representations, what is in there semantically. And then a lot of sort of exciting updates that were, you know, are sort of also part of the, the fundraise around bringing interpretability to training, which I don't think has been done all that much before. A lot of this stuff is sort of post-talk poking at models as opposed to. To actually using this to intentionally design them.Shawn Wang [00:07:29]: Is this post-training or pre-training or is that not a useful.Myra Deng [00:07:33]: Currently focused on post-training, but there's no reason the techniques wouldn't also work in pre-training.Shawn Wang [00:07:38]: Yeah. It seems like it would be more active, applicable post-training because basically I'm thinking like rollouts or like, you know, having different variations of a model that you can tweak with the, with your steering. Yeah.Myra Deng [00:07:50]: And I think in a lot of the news that you've seen in, in, on like Twitter or whatever, you've seen a lot of unintended. Side effects come out of post-training processes, you know, overly sycophantic models or models that exhibit strange reward hacking behavior. I think these are like extreme examples. There's also, you know, very, uh, mundane, more mundane, like enterprise use cases where, you know, they try to customize or post-train a model to do something and it learns some noise or it doesn't appropriately learn the target task. And a big question that we've always had is like, how do you use your understanding of what the model knows and what it's doing to actually guide the learning process?Shawn Wang [00:08:26]: Yeah, I mean, uh, you know, just to anchor this for people, uh, one of the biggest controversies of last year was 4.0 GlazeGate. I've never heard of GlazeGate. I didn't know that was what it was called. The other one, they called it that on the blog post and I was like, well, how did OpenAI call it? Like officially use that term. And I'm like, that's funny, but like, yeah, I guess it's the pitch that if they had worked a good fire, they wouldn't have avoided it. Like, you know what I'm saying?Myra Deng [00:08:51]: I think so. Yeah. Yeah.Mark Bissell [00:08:53]: I think that's certainly one of the use cases. I think. Yeah. Yeah. I think the reason why post-training is a place where this makes a lot of sense is a lot of what we're talking about is surgical edits. You know, you want to be able to have expert feedback, very surgically change how your model is doing, whether that is, you know, removing a certain behavior that it has. So, you know, one of the things that we've been looking at or is, is another like common area where you would want to make a somewhat surgical edit is some of the models that have say political bias. Like you look at Quen or, um, R1 and they have sort of like this CCP bias.Shawn Wang [00:09:27]: Is there a CCP vector?Mark Bissell [00:09:29]: Well, there's, there are certainly internal, yeah. Parts of the representation space where you can sort of see where that lives. Yeah. Um, and you want to kind of, you know, extract that piece out.Shawn Wang [00:09:40]: Well, I always say, you know, whenever you find a vector, a fun exercise is just like, make it very negative to see what the opposite of CCP is.Mark Bissell [00:09:47]: The super America, bald eagles flying everywhere. But yeah. So in general, like lots of post-training tasks where you'd want to be able to, to do that. Whether it's unlearning a certain behavior or, you know, some of the other kind of cases where this comes up is, are you familiar with like the, the grokking behavior? I mean, I know the machine learning term of grokking.Shawn Wang [00:10:09]: Yeah.Mark Bissell [00:10:09]: Sort of this like double descent idea of, of having a model that is able to learn a generalizing, a generalizing solution, as opposed to even if memorization of some task would suffice, you want it to learn the more general way of doing a thing. And so, you know, another. A way that you can think about having surgical access to a model's internals would be learn from this data, but learn in the right way. If there are many possible, you know, ways to, to do that. Can make interp solve the double descent problem?Shawn Wang [00:10:41]: Depends, I guess, on how you. Okay. So I, I, I viewed that double descent as a problem because then you're like, well, if the loss curves level out, then you're done, but maybe you're not done. Right. Right. But like, if you actually can interpret what is a generalizing or what you're doing. What is, what is still changing, even though the loss is not changing, then maybe you, you can actually not view it as a double descent problem. And actually you're just sort of translating the space in which you view loss and like, and then you have a smooth curve. Yeah.Mark Bissell [00:11:11]: I think that's certainly like the domain of, of problems that we're, that we're looking to get.Shawn Wang [00:11:15]: Yeah. To me, like double descent is like the biggest thing to like ML research where like, if you believe in scaling, then you don't need, you need to know where to scale. And. But if you believe in double descent, then you don't, you don't believe in anything where like anything levels off, like.Vibhu Sapra [00:11:30]: I mean, also tendentially there's like, okay, when you talk about the China vector, right. There's the subliminal learning work. It was from the anthropic fellows program where basically you can have hidden biases in a model. And as you distill down or, you know, as you train on distilled data, those biases always show up, even if like you explicitly try to not train on them. So, you know, it's just like another use case of. Okay. If we can interpret what's happening in post-training, you know, can we clear some of this? Can we even determine what's there? Because yeah, it's just like some worrying research that's out there that shows, you know, we really don't know what's going on.Mark Bissell [00:12:06]: That is. Yeah. I think that's the biggest sentiment that we're sort of hoping to tackle. Nobody knows what's going on. Right. Like subliminal learning is just an insane concept when you think about it. Right. Train a model on not even the logits, literally the output text of a bunch of random numbers. And now your model loves owls. And you see behaviors like that, that are just, they defy, they defy intuition. And, and there are mathematical explanations that you can get into, but. I mean.Shawn Wang [00:12:34]: It feels so early days. Objectively, there are a sequence of numbers that are more owl-like than others. There, there should be.Mark Bissell [00:12:40]: According to, according to certain models. Right. It's interesting. I think it only applies to models that were initialized from the same starting Z. Usually, yes.Shawn Wang [00:12:49]: But I mean, I think that's a, that's a cheat code because there's not enough compute. But like if you believe in like platonic representation, like probably it will transfer across different models as well. Oh, you think so?Mark Bissell [00:13:00]: I think of it more as a statistical artifact of models initialized from the same seed sort of. There's something that is like path dependent from that seed that might cause certain overlaps in the latent space and then sort of doing this distillation. Yeah. Like it pushes it towards having certain other tendencies.Vibhu Sapra [00:13:24]: Got it. I think there's like a bunch of these open-ended questions, right? Like you can't train in new stuff during the RL phase, right? RL only reorganizes weights and you can only do stuff that's somewhat there in your base model. You're not learning new stuff. You're just reordering chains and stuff. But okay. My broader question is when you guys work at an interp lab, how do you decide what to work on and what's kind of the thought process? Right. Because we can ramble for hours. Okay. I want to know this. I want to know that. But like, how do you concretely like, you know, what's the workflow? Okay. There's like approaches towards solving a problem, right? I can try prompting. I can look at chain of thought. I can train probes, SAEs. But how do you determine, you know, like, okay, is this going anywhere? Like, do we have set stuff? Just, you know, if you can help me with all that. Yeah.Myra Deng [00:14:07]: It's a really good question. I feel like we've always at the very beginning of the company thought about like, let's go and try to learn what isn't working in machine learning today. Whether that's talking to customers or talking to researchers at other labs, trying to understand both where the frontier is going and where things are really not falling apart today. And then developing a perspective on how we can push the frontier using interpretability methods. And so, you know, even our chief scientist, Tom, spends a lot of time talking to customers and trying to understand what real world problems are and then taking that back and trying to apply the current state of the art to those problems and then seeing where they fall down basically. And then using those failures or those shortcomings to understand what hills to climb when it comes to interpretability research. So like on the fundamental side, for instance, when we have done some work applying SAEs and probes, we've encountered, you know, some shortcomings in SAEs that we found a little bit surprising. And so have gone back to the drawing board and done work on that. And then, you know, we've done some work on better foundational interpreter models. And a lot of our team's research is focused on what is the next evolution beyond SAEs, for instance. And then when it comes to like control and design of models, you know, we tried steering with our first API and realized that it still fell short of black box techniques like prompting or fine tuning. And so went back to the drawing board and we're like, how do we make that not the case and how do we improve it beyond that? And one of our researchers, Ekdeep, who just joined is actually Ekdeep and Atticus are like steering experts and have spent a lot of time trying to figure out like, what is the research that enables us to actually do this in a much more powerful, robust way? So yeah, the answer is like, look at real world problems, try to translate that into a research agenda and then like hill climb on both of those at the same time.Shawn Wang [00:16:04]: Yeah. Mark has the steering CLI demo queued up, which we're going to go into in a sec. But I always want to double click on when you drop hints, like we found some problems with SAEs. Okay. What are they? You know, and then we can go into the demo. Yeah.Myra Deng [00:16:19]: I mean, I'm curious if you have more thoughts here as well, because you've done it in the healthcare domain. But I think like, for instance, when we do things like trying to detect behaviors within models that are harmful or like behaviors that a user might not want to have in their model. So hallucinations, for instance, harmful intent, PII, all of these things. We first tried using SAE probes for a lot of these tasks. So taking the feature activation space from SAEs and then training classifiers on top of that, and then seeing how well we can detect the properties that we might want to detect in model behavior. And we've seen in many cases that probes just trained on raw activations seem to perform better than SAE probes, which is a bit surprising if you think that SAEs are actually also capturing the concepts that you would want to capture cleanly and more surgically. And so that is an interesting observation. I don't think that is like, I'm not down on SAEs at all. I think there are many, many things they're useful for, but we have definitely run into cases where I think the concept space described by SAEs is not as clean and accurate as we would expect it to be for actual like real world downstream performance metrics.Mark Bissell [00:17:34]: Fair enough. Yeah. It's the blessing and the curse of unsupervised methods where you get to peek into the AI's mind. But sometimes you wish that you saw other things when you walked inside there. Although in the PII instance, I think weren't an SAE based approach actually did prove to be the most generalizable?Myra Deng [00:17:53]: It did work well in the case that we published with Rakuten. And I think a lot of the reasons it worked well was because we had a noisier data set. And so actually the blessing of unsupervised learning is that we actually got to get more meaningful, generalizable signal from SAEs when the data was noisy. But in other cases where we've had like good data sets, it hasn't been the case.Shawn Wang [00:18:14]: And just because you named Rakuten and I don't know if we'll get it another chance, like what is the overall, like what is Rakuten's usage or production usage? Yeah.Myra Deng [00:18:25]: So they are using us to essentially guardrail and inference time monitor their language model usage and their agent usage to detect things like PII so that they don't route private user information.Myra Deng [00:18:41]: And so that's, you know, going through all of their user queries every day. And that's something that we deployed with them a few months ago. And now we are actually exploring very early partnerships, not just with Rakuten, but with other people around how we can help with potentially training and customization use cases as well. Yeah.Shawn Wang [00:19:03]: And for those who don't know, like it's Rakuten is like, I think number one or number two e-commerce store in Japan. Yes. Yeah.Mark Bissell [00:19:10]: And I think that use case actually highlights a lot of like what it looks like to deploy things in practice that you don't always think about when you're doing sort of research tasks. So when you think about some of the stuff that came up there that's more complex than your idealized version of a problem, they were encountering things like synthetic to real transfer of methods. So they couldn't train probes, classifiers, things like that on actual customer data of PII. So what they had to do is use synthetic data sets. And then hope that that transfer is out of domain to real data sets. And so we can evaluate performance on the real data sets, but not train on customer PII. So that right off the bat is like a big challenge. You have multilingual requirements. So this needed to work for both English and Japanese text. Japanese text has all sorts of quirks, including tokenization behaviors that caused lots of bugs that caused us to be pulling our hair out. And then also a lot of tasks you'll see. You might make simplifying assumptions if you're sort of treating it as like the easiest version of the problem to just sort of get like general results where maybe you say you're classifying a sentence to say, does this contain PII? But the need that Rakuten had was token level classification so that you could precisely scrub out the PII. So as we learned more about the problem, you're sort of speaking about what that looks like in practice. Yeah. A lot of assumptions end up breaking. And that was just one instance where you. A problem that seems simple right off the bat ends up being more complex as you keep diving into it.Vibhu Sapra [00:20:41]: Excellent. One of the things that's also interesting with Interp is a lot of these methods are very efficient, right? So where you're just looking at a model's internals itself compared to a separate like guardrail, LLM as a judge, a separate model. One, you have to host it. Two, there's like a whole latency. So if you use like a big model, you have a second call. Some of the work around like self detection of hallucination, it's also deployed for efficiency, right? So if you have someone like Rakuten doing it in production live, you know, that's just another thing people should consider.Mark Bissell [00:21:12]: Yeah. And something like a probe is super lightweight. Yeah. It's no extra latency really. Excellent.Shawn Wang [00:21:17]: You have the steering demos lined up. So we were just kind of see what you got. I don't, I don't actually know if this is like the latest, latest or like alpha thing.Mark Bissell [00:21:26]: No, this is a pretty hacky demo from from a presentation that someone else on the team recently gave. So this will give a sense for, for technology. So you can see the steering and action. Honestly, I think the biggest thing that this highlights is that as we've been growing as a company and taking on kind of more and more ambitious versions of interpretability related problems, a lot of that comes to scaling up in various different forms. And so here you're going to see steering on a 1 trillion parameter model. This is Kimi K2. And so it's sort of fun that in addition to the research challenges, there are engineering challenges that we're now tackling. Cause for any of this to be sort of useful in production, you need to be thinking about what it looks like when you're using these methods on frontier models as opposed to sort of like toy kind of model organisms. So yeah, this was thrown together hastily, pretty fragile behind the scenes, but I think it's quite a fun demo. So screen sharing is on. So I've got two terminal sessions pulled up here. On the left is a forked version that we have of the Kimi CLI that we've got running to point at our custom hosted Kimi model. And then on the right is a set up that will allow us to steer on certain concepts. So I should be able to chat with Kimi over here. Tell it hello. This is running locally. So the CLI is running locally, but the Kimi server is running back to the office. Well, hopefully should be, um, that's too much to run on that Mac. Yeah. I think it's, uh, it takes a full, like each 100 node. I think it's like, you can. You can run it on eight GPUs, eight 100. So, so yeah, Kimi's running. We can ask it a prompt. It's got a forked version of our, uh, of the SG line code base that we've been working on. So I'm going to tell it, Hey, this SG line code base is slow. I think there's a bug. Can you try to figure it out? There's a big code base, so it'll, it'll spend some time doing this. And then on the right here, I'm going to initialize in real time. Some steering. Let's see here.Mark Bissell [00:23:33]: searching for any. Bugs. Feature ID 43205.Shawn Wang [00:23:38]: Yeah.Mark Bissell [00:23:38]: 20, 30, 40. So let me, uh, this is basically a feature that we found that inside Kimi seems to cause it to speak in Gen Z slang. And so on the left, it's still sort of thinking normally it might take, I don't know, 15 seconds for this to kick in, but then we're going to start hopefully seeing him do this code base is massive for real. So we're going to start. We're going to start seeing Kimi transition as the steering kicks in from normal Kimi to Gen Z Kimi and both in its chain of thought and its actual outputs.Mark Bissell [00:24:19]: And interestingly, you can see, you know, it's still able to call tools, uh, and stuff. It's um, it's purely sort of it's it's demeanor. And there are other features that we found for interesting things like concision. So that's more of a practical one. You can make it more concise. Um, the types of programs, uh, programming languages that uses, but yeah, as we're seeing it come in. Pretty good. Outputs.Shawn Wang [00:24:43]: Scheduler code is actually wild.Vibhu Sapra [00:24:46]: Yo, this code is actually insane, bro.Vibhu Sapra [00:24:53]: What's the process of training in SAE on this, or, you know, how do you label features? I know you guys put out a pretty cool blog post about, um, finding this like autonomous interp. Um, something. Something about how agents for interp is different than like coding agents. I don't know while this is spewing up, but how, how do we find feature 43, two Oh five. Yeah.Mark Bissell [00:25:15]: So in this case, um, we, our platform that we've been building out for a long time now supports all the sort of classic out of the box interp techniques that you might want to have like SAE training, probing things of that kind, I'd say the techniques for like vanilla SAEs are pretty well established now where. You take your model that you're interpreting, run a whole bunch of data through it, gather activations, and then yeah, pretty straightforward pipeline to train an SAE. There are a lot of different varieties. There's top KSAEs, batch top KSAEs, um, normal ReLU SAEs. And then once you have your sparse features to your point, assigning labels to them to actually understand that this is a gen Z feature, that's actually where a lot of the kind of magic happens. Yeah. And the most basic standard technique is look at all of your d input data set examples that cause this feature to fire most highly. And then you can usually pick out a pattern. So for this feature, If I've run a diverse enough data set through my model feature 43, two Oh five. Probably tends to fire on all the tokens that sounds like gen Z slang. You know, that's the, that's the time of year to be like, Oh, I'm in this, I'm in this Um, and, um, so, you know, you could have a human go through all 43,000 concepts andVibhu Sapra [00:26:34]: And I've got to ask the basic question, you know, can we get examples where it hallucinates, pass it through, see what feature activates for hallucinations? Can I just, you know, turn hallucination down?Myra Deng [00:26:51]: Oh, wow. You really predicted a project we're already working on right now, which is detecting hallucinations using interpretability techniques. And this is interesting because hallucinations is something that's very hard to detect. And it's like a kind of a hairy problem and something that black box methods really struggle with. Whereas like Gen Z, you could always train a simple classifier to detect that hallucinations is harder. But we've seen that models internally have some... Awareness of like uncertainty or some sort of like user pleasing behavior that leads to hallucinatory behavior. And so, yeah, we have a project that's trying to detect that accurately. And then also working on mitigating the hallucinatory behavior in the model itself as well.Shawn Wang [00:27:39]: Yeah, I would say most people are still at the level of like, oh, I would just turn temperature to zero and that turns off hallucination. And I'm like, well, that's a fundamental misunderstanding of how this works. Yeah.Mark Bissell [00:27:51]: Although, so part of what I like about that question is you, there are SAE based approaches that might like help you get at that. But oftentimes the beauty of SAEs and like we said, the curse is that they're unsupervised. So when you have a behavior that you deliberately would like to remove, and that's more of like a supervised task, often it is better to use something like probes and specifically target the thing that you're interested in reducing as opposed to sort of like hoping that when you fragment the latent space, one of the vectors that pops out.Vibhu Sapra [00:28:20]: And as much as we're training an autoencoder to be sparse, we're not like for sure certain that, you know, we will get something that just correlates to hallucination. You'll probably split that up into 20 other things and who knows what they'll be.Mark Bissell [00:28:36]: Of course. Right. Yeah. So there's no sort of problems with like feature splitting and feature absorption. And then there's the off target effects, right? Ideally, you would want to be very precise where if you reduce the hallucination feature, suddenly maybe your model can't write. Creatively anymore. And maybe you don't like that, but you want to still stop it from hallucinating facts and figures.Shawn Wang [00:28:55]: Good. So Vibhu has a paper to recommend there that we'll put in the show notes. But yeah, I mean, I guess just because your demo is done, any any other things that you want to highlight or any other interesting features you want to show?Mark Bissell [00:29:07]: I don't think so. Yeah. Like I said, this is a pretty small snippet. I think the main sort of point here that I think is exciting is that there's not a whole lot of inter being applied to models quite at this scale. You know, Anthropic certainly has some some. Research and yeah, other other teams as well. But it's it's nice to see these techniques, you know, being put into practice. I think not that long ago, the idea of real time steering of a trillion parameter model would have sounded.Shawn Wang [00:29:33]: Yeah. The fact that it's real time, like you started the thing and then you edited the steering vector.Vibhu Sapra [00:29:38]: I think it's it's an interesting one TBD of what the actual like production use case would be on that, like the real time editing. It's like that's the fun part of the demo, right? You can kind of see how this could be served behind an API, right? Like, yes, you're you only have so many knobs and you can just tweak it a bit more. And I don't know how it plays in. Like people haven't done that much with like, how does this work with or without prompting? Right. How does this work with fine tuning? Like, there's a whole hype of continual learning, right? So there's just so much to see. Like, is this another parameter? Like, is it like parameter? We just kind of leave it as a default. We don't use it. So I don't know. Maybe someone here wants to put out a guide on like how to use this with prompting when to do what?Mark Bissell [00:30:18]: Oh, well, I have a paper recommendation. I think you would love from Act Deep on our team, who is an amazing researcher, just can't say enough amazing things about Act Deep. But he actually has a paper that as well as some others from the team and elsewhere that go into the essentially equivalence of activation steering and in context learning and how those are from a he thinks of everything in a cognitive neuroscience Bayesian framework, but basically how you can precisely show how. Prompting in context, learning and steering exhibit similar behaviors and even like get quantitative about the like magnitude of steering you would need to do to induce a certain amount of behavior similar to certain prompting, even for things like jailbreaks and stuff. It's a really cool paper. Are you saying steering is less powerful than prompting? More like you can almost write a formula that tells you how to convert between the two of them.Myra Deng [00:31:20]: And so like formally equivalent actually in the in the limit. Right.Mark Bissell [00:31:24]: So like one case study of this is for jailbreaks there. I don't know. Have you seen the stuff where you can do like many shot jailbreaking? You like flood the context with examples of the behavior. And the topic put out that paper.Shawn Wang [00:31:38]: A lot of people were like, yeah, we've been doing this, guys.Mark Bissell [00:31:40]: Like, yeah, what's in this in context learning and activation steering equivalence paper is you can like predict the number. Number of examples that you will need to put in there in order to jailbreak the model. That's cool. By doing steering experiments and using this sort of like equivalence mapping. That's cool. That's really cool. It's very neat. Yeah.Shawn Wang [00:32:02]: I was going to say, like, you know, I can like back rationalize that this makes sense because, you know, what context is, is basically just, you know, it updates the KV cache kind of and like and then every next token inference is still like, you know, the sheer sum of everything all the way. It's plus all the context. It's up to date. And you could, I guess, theoretically steer that with you probably replace that with your steering. The only problem is steering typically is on one layer, maybe three layers like like you did. So it's like not exactly equivalent.Mark Bissell [00:32:33]: Right, right. There's sort of you need to get precise about, yeah, like how you sort of define steering and like what how you're modeling the setup. But yeah, I've got the paper pulled up here. Belief dynamics reveal the dual nature. Yeah. The title is Belief Dynamics Reveal the Dual Nature of Incompetence. And it's an exhibition of the practical context learning and activation steering. So Eric Bigelow, Dan Urgraft on the who are doing fellowships at Goodfire, Ekt Deep's the final author there.Myra Deng [00:32:59]: I think actually to your question of like, what is the production use case of steering? I think maybe if you just think like one level beyond steering as it is today. Like imagine if you could adapt your model to be, you know, an expert legal reasoner. Like in almost real time, like very quickly. efficiently using human feedback or using like your semantic understanding of what the model knows and where it knows that behavior. I think that while it's not clear what the product is at the end of the day, it's clearly very valuable. Thinking about like what's the next interface for model customization and adaptation is a really interesting problem for us. Like we have heard a lot of people actually interested in fine-tuning an RL for open weight models in production. And so people are using things like Tinker or kind of like open source libraries to do that, but it's still very difficult to get models fine-tuned and RL'd for exactly what you want them to do unless you're an expert at model training. And so that's like something we'reShawn Wang [00:34:06]: looking into. Yeah. I never thought so. Tinker from Thinking Machines famously uses rank one LoRa. Is that basically the same as steering? Like, you know, what's the comparison there?Mark Bissell [00:34:19]: Well, so in that case, you are still applying updates to the parameters, right?Shawn Wang [00:34:25]: Yeah. You're not touching a base model. You're touching an adapter. It's kind of, yeah.Mark Bissell [00:34:30]: Right. But I guess it still is like more in parameter space then. I guess it's maybe like, are you modifying the pipes or are you modifying the water flowing through the pipes to get what you're after? Yeah. Just maybe one way.Mark Bissell [00:34:44]: I like that analogy. That's my mental map of it at least, but it gets at this idea of model design and intentional design, which is something that we're, that we're very focused on. And just the fact that like, I hope that we look back at how we're currently training models and post-training models and just think what a primitive way of doing that right now. Like there's no intentionalityShawn Wang [00:35:06]: really in... It's just data, right? The only thing in control is what data we feed in.Mark Bissell [00:35:11]: So, so Dan from Goodfire likes to use this analogy of, you know, he has a couple of young kids and he talks about like, what if I could only teach my kids how to be good people by giving them cookies or like, you know, giving them a slap on the wrist if they do something wrong, like not telling them why it was wrong or like what they should have done differently or something like that. Just figure it out. Right. Exactly. So that's RL. Yeah. Right. And, and, you know, it's sample inefficient. There's, you know, what do they say? It's like slurping feedback. It's like, slurping supervision. Right. And so you'd like to get to the point where you can have experts giving feedback to their models that are, uh, internalized and, and, you know, steering is an inference time way of sort of getting that idea. But ideally you're moving to a world whereVibhu Sapra [00:36:04]: it is much more intentional design in perpetuity for these models. Okay. This is one of the questions we asked Emmanuel from Anthropic on the podcast a few months ago. Basically the question, was you're at a research lab that does model training, foundation models, and you're on an interp team. How does it tie back? Right? Like, does this, do ideas come from the pre-training team? Do they go back? Um, you know, so for those interested, you can, you can watch that. There wasn't too much of a connect there, but it's still something, you know, it's something they want toMark Bissell [00:36:33]: push for down the line. It can be useful for all of the above. Like there are certainly post-hocVibhu Sapra [00:36:39]: use cases where it doesn't need to touch that. I think the other thing a lot of people forget is this stuff isn't too computationally expensive, right? Like I would say, if you're interested in getting into research, MechInterp is one of the most approachable fields, right? A lot of this train an essay, train a probe, this stuff, like the budget for this one, there's already a lot done. There's a lot of open source work. You guys have done some too. Um, you know,Shawn Wang [00:37:04]: There's like notebooks from the Gemini team for Neil Nanda or like, this is how you do it. Just step through the notebook.Vibhu Sapra [00:37:09]: Even if you're like, not even technical with any of this, you can still make like progress. There, you can look at different activations, but, uh, if you do want to get into training, you know, training this stuff, correct me if I'm wrong is like in the thousands of dollars, not even like, it's not that high scale. And then same with like, you know, applying it, doing it for post-training or all this stuff is fairly cheap in scale of, okay. I want to get into like model training. I don't have compute for like, you know, pre-training stuff. So it's, it's a very nice field to get into. And also there's a lot of like open questions, right? Um, some of them have to go with, okay, I want a product. I want to solve this. Like there's also just a lot of open-ended stuff that people could work on. That's interesting. Right. I don't know if you guys have any calls for like, what's open questions, what's open work that you either open collaboration with, or like, you'd just like to see solved or just, you know, for people listening that want to get into McInturk because people always talk about it. What are, what are the things they should check out? Start, of course, you know, join you guys as well. I'm sure you're hiring.Myra Deng [00:38:09]: There's a paper, I think from, was it Lee, uh, Sharky? It's open problems and, uh, it's, it's a bit of interpretability, which I recommend everyone who's interested in the field. Read. I'm just like a really comprehensive overview of what are the things that experts in the field think are the most important problems to be solved. I also think to your point, it's been really, really inspiring to see, I think a lot of young people getting interested in interpretability, actually not just young people also like scientists to have been, you know, experts in physics for many years and in biology or things like this, um, transitioning into interp, because the barrier of, of what's now interp. So it's really cool to see a number to entry is, you know, in some ways low and there's a lot of information out there and ways to get started. There's this anecdote of like professors at universities saying that all of a sudden every incoming PhD student wants to study interpretability, which was not the case a few years ago. So it just goes to show how, I guess, like exciting the field is, how fast it's moving, how quick it is to get started and things like that.Mark Bissell [00:39:10]: And also just a very welcoming community. You know, there's an open source McInturk Slack channel. There are people are always posting questions and just folks in the space are always responsive if you ask things on various forums and stuff. But yeah, the open paper, open problems paper is a really good one.Myra Deng [00:39:28]: For other people who want to get started, I think, you know, MATS is a great program. What's the acronym for? Machine Learning and Alignment Theory Scholars? It's like the...Vibhu Sapra [00:39:40]: Normally summer internship style.Myra Deng [00:39:42]: Yeah, but they've been doing it year round now. And actually a lot of our full-time staff have come through that program or gone through that program. And it's great for anyone who is transitioning into interpretability. There's a couple other fellows programs. We do one as well as Anthropic. And so those are great places to get started if anyone is interested.Mark Bissell [00:40:03]: Also, I think been seen as a research field for a very long time. But I think engineering... I think engineers are sorely wanted for interpretability as well, especially at Goodfire, but elsewhere, as it does scale up.Shawn Wang [00:40:18]: I should mention that Lee actually works with you guys, right? And in the London office and I'm adding our first ever McInturk track at AI Europe because I see this industry applications now emerging. And I'm pretty excited to, you know, help push that along. Yeah, I was looking forward to that. It'll effectively be the first industry McInturk conference. Yeah. I'm so glad you added that. You know, it's still a little bit of a bet. It's not that widespread, but I can definitely see this is the time to really get into it. We want to be early on things.Mark Bissell [00:40:51]: For sure. And I think the field understands this, right? So at ICML, I think the title of the McInturk workshop this year was actionable interpretability. And there was a lot of discussion around bringing it to various domains. Everyone's adding pragmatic, actionable, whatever.Shawn Wang [00:41:10]: It's like, okay, well, we weren't actionable before, I guess. I don't know.Vibhu Sapra [00:41:13]: And I mean, like, just, you know, being in Europe, you see the Interp room. One, like old school conferences, like, I think they had a very tiny room till they got lucky and they got it doubled. But there's definitely a lot of interest, a lot of niche research. So you see a lot of research coming out of universities, students. We covered the paper last week. It's like two unknown authors, not many citations. But, you know, you can make a lot of meaningful work there. Yeah. Yeah. Yeah.Shawn Wang [00:41:39]: Yeah. I think people haven't really mentioned this yet. It's just Interp for code. I think it's like an abnormally important field. We haven't mentioned this yet. The conspiracy theory last two years ago was when the first SAE work came out of Anthropic was they would do like, oh, we just used SAEs to turn the bad code vector down and then turn up the good code. And I think like, isn't that the dream? Like, you know, like, but basically, I guess maybe, why is it funny? Like, it's... If it was realistic, it would not be funny. It would be like, no, actually, we should do this. But it's funny because we know there's like, we feel there's some limitations to what steering can do. And I think a lot of the public image of steering is like the Gen Z stuff. Like, oh, you can make it really love the Golden Gate Bridge, or you can make it speak like Gen Z. To like be a legal reasoner seems like a huge stretch. Yeah. And I don't know if that will get there this way. Yeah.Myra Deng [00:42:36]: I think, um, I will say we are announcing. Something very soon that I will not speak too much about. Um, but I think, yeah, this is like what we've run into again and again is like, we, we don't want to be in the world where steering is only useful for like stylistic things. That's definitely not, not what we're aiming for. But I think the types of interventions that you need to do to get to things like legal reasoning, um, are much more sophisticated and require breakthroughs in, in learning algorithms. And that's, um...Shawn Wang [00:43:07]: And is this an emergent property of scale as well?Myra Deng [00:43:10]: I think so. Yeah. I mean, I think scale definitely helps. I think scale allows you to learn a lot of information and, and reduce noise across, you know, large amounts of data. But I also think we think that there's ways to do things much more effectively, um, even, even at scale. So like actually learning exactly what you want from the data and not learning things that you do that you don't want exhibited in the data. So we're not like anti-scale, but we are also realizing that scale is not going to get us anywhere. It's not going to get us to the type of AI development that we want to be at in, in the future as these models get more powerful and get deployed in all these sorts of like mission critical contexts. Current life cycle of training and deploying and evaluations is, is to us like deeply broken and has opportunities to, to improve. So, um, more to come on that very, very soon.Mark Bissell [00:44:02]: And I think that that's a use basically, or maybe just like a proof point that these concepts do exist. Like if you can manipulate them in the precise best way, you can get the ideal combination of them that you desire. And steering is maybe the most coarse grained sort of peek at what that looks like. But I think it's evocative of what you could do if you had total surgical control over every concept, every parameter. Yeah, exactly.Myra Deng [00:44:30]: There were like bad code features. I've got it pulled up.Vibhu Sapra [00:44:33]: Yeah. Just coincidentally, as you guys are talking.Shawn Wang [00:44:35]: This is like, this is exactly.Vibhu Sapra [00:44:38]: There's like specifically a code error feature that activates and they show, you know, it's not, it's not typo detection. It's like, it's, it's typos in code. It's not typical typos. And, you know, you can, you can see it clearly activates where there's something wrong in code. And they have like malicious code, code error. They have a whole bunch of sub, you know, sub broken down little grain features. Yeah.Shawn Wang [00:45:02]: Yeah. So, so the, the rough intuition for me, the, why I talked about post-training was that, well, you just, you know, have a few different rollouts with all these things turned off and on and whatever. And then, you know, you can, that's, that's synthetic data you can kind of post-train on. Yeah.Vibhu Sapra [00:45:13]: And I think we make it sound easier than it is just saying, you know, they do the real hard work.Myra Deng [00:45:19]: I mean, you guys, you guys have the right idea. Exactly. Yeah. We replicated a lot of these features in, in our Lama models as well. I remember there was like.Vibhu Sapra [00:45:26]: And I think a lot of this stuff is open, right? Like, yeah, you guys opened yours. DeepMind has opened a lot of essays on Gemma. Even Anthropic has opened a lot of this. There's, there's a lot of resources that, you know, we can probably share of people that want to get involved.Shawn Wang [00:45:41]: Yeah. And special shout out to like Neuronpedia as well. Yes. Like, yeah, amazing piece of work to visualize those things.Myra Deng [00:45:49]: Yeah, exactly.Shawn Wang [00:45:50]: I guess I wanted to pivot a little bit on, onto the healthcare side, because I think that's a big use case for you guys. We haven't really talked about it yet. This is a bit of a crossover for me because we are, we are, we do have a separate science pod that we're starting up for AI, for AI for science, just because like, it's such a huge investment category and also I'm like less qualified to do it, but we actually have bio PhDs to cover that, which is great, but I need to just kind of recover, recap your work, maybe on the evil two stuff, but then, and then building forward.Mark Bissell [00:46:17]: Yeah, for sure. And maybe to frame up the conversation, I think another kind of interesting just lens on interpretability in general is a lot of the techniques that were described. are ways to solve the AI human interface problem. And it's sort of like bidirectional communication is the goal there. So what we've been talking about with intentional design of models and, you know, steering, but also more advanced techniques is having humans impart our desires and control into models and over models. And the reverse is also very interesting, especially as you get to superhuman models, whether that's narrow superintelligence, like these scientific models that work on genomics, data, medical imaging, things like that. But down the line, you know, superintelligence of other forms as well. What knowledge can the AIs teach us as sort of that, that the other direction in that? And so some of our life science work to date has been getting at exactly that question, which is, well, some of it does look like debugging these various life sciences models, understanding if they're actually performing well, on tasks, or if they're picking up on spurious correlations, for instance, genomics models, you would like to know whether they are sort of focusing on the biologically relevant things that you care about, or if it's using some simpler correlate, like the ancestry of the person that it's looking at. But then also in the instances where they are superhuman, and maybe they are understanding elements of the human genome that we don't have names for or specific, you know, yeah, discoveries that they've made that that we don't know about, that's, that's a big goal. And so we're already seeing that, right, we are partnered with organizations like Mayo Clinic, leading research health system in the United States, our Institute, as well as a startup called Prima Menta, which focuses on neurodegenerative disease. And in our partnership with them, we've used foundation models, they've been training and applied our interpretability techniques to find novel biomarkers for Alzheimer's disease. So I think this is just the tip of the iceberg. But it's, that's like a flavor of some of the things that we're working on.Shawn Wang [00:48:36]: Yeah, I think that's really fantastic. Obviously, we did the Chad Zuckerberg pod last year as well. And like, there's a plethora of these models coming out, because there's so much potential and research. And it's like, very interesting how it's basically the same as language models, but just with a different underlying data set. But it's like, it's the same exact techniques. Like, there's no change, basically.Mark Bissell [00:48:59]: Yeah. Well, and even in like other domains, right? Like, you know, robotics, I know, like a lot of the companies just use Gemma as like the like backbone, and then they like make it into a VLA that like takes these actions. It's, it's, it's transformers all the way down. So yeah.Vibhu Sapra [00:49:15]: Like we have Med Gemma now, right? Like this week, even there was Med Gemma 1.5. And they're training it on this stuff, like 3d scans, medical domain knowledge, and all that stuff, too. So there's a push from both sides. But I think the thing that, you know, one of the things about McInturpp is like, you're a little bit more cautious in some domains, right? So healthcare, mainly being one, like guardrails, understanding, you know, we're more risk adverse to something going wrong there. So even just from a basic understanding, like, if we're trusting these systems to make claims, we want to know why and what's going on.Myra Deng [00:49:51]: Yeah, I think there's totally a kind of like deployment bottleneck to actually using. foundation models for real patient usage or things like that. Like, say you're using a model for rare disease prediction, you probably want some explanation as to why your model predicted a certain outcome, and an interpretable explanation at that. So that's definitely a use case. But I also think like, being able to extract scientific information that no human knows to accelerate drug discovery and disease treatment and things like that actually is a really, really big unlock for science, like scientific discovery. And you've seen a lot of startups, like say that they're going to accelerate scientific discovery. And I feel like we actually are doing that through our interp techniques. And kind of like, almost by accident, like, I think we got reached out to very, very early on from these healthcare institutions. And none of us had healthcare.Shawn Wang [00:50:49]: How did they even hear of you? A podcast.Myra Deng [00:50:51]: Oh, okay. Yeah, podcast.Vibhu Sapra [00:50:53]: Okay, well, now's that time, you know.Myra Deng [00:50:55]: Everyone can call us.Shawn Wang [00:50:56]: Podcasts are the most important thing. Everyone should listen to podcasts.Myra Deng [00:50:59]: Yeah, they reached out. They were like, you know, we have these really smart models that we've trained, and we want to know what they're doing. And we were like, really early that time, like three months old, and it was a few of us. And we were like, oh, my God, we've never used these models. Let's figure it out. But it's also like, great proof that interp techniques scale pretty well across domains. We didn't really have to learn too much about.Shawn Wang [00:51:21]: Interp is a machine learning technique, machine learning skills everywhere, right? Yeah. And it's obviously, it's just like a general insight. Yeah. Probably to finance too, I think, which would be fun for our history. I don't know if you have anything to say there.Mark Bissell [00:51:34]: Yeah, well, just across the science. Like, we've also done work on material science. Yeah, it really runs the gamut.Vibhu Sapra [00:51:40]: Yeah. Awesome. And, you know, for those that should reach out, like, you're obviously experts in this, but like, is there a call out for people that you're looking to partner with, design partners, people to use your stuff outside of just, you know, the general developer that wants to. Plug and play steering stuff, like on the research side more so, like, are there ideal design partners, customers, stuff like that?Myra Deng [00:52:03]: Yeah, I can talk about maybe non-life sciences, and then I'm curious to hear from you on the life sciences side. But we're looking for design partners across many domains, language, anyone who's customizing language models or trying to push the frontier of code or reasoning models is really interesting to us. And then also interested in the frontier of modeling. There's a lot of models that work in, like, pixel space, as we call it. So if you're doing world models, video models, even robotics, where there's not a very clean natural language interface to interact with, I think we think that Interp can really help and are looking for a few partners in that space.Shawn Wang [00:52:43]: Just because you mentioned the keyword

Gamers are cooked. NVIDIA is delaying its new GPUs and chasing the AI chuckwagon. Of course they are -- gamers make up a SMALL part of their customer base. But this will have a trickle down effect on gaming. New consoles are likely YEARS off, and price hikes are inevitable. Sony is now BEGGING PlayStation 4 owners to buy a PS5 because the PS6 is probably a few years away. Can I interest you in some RETRO gaming...?Watch the podcast episodes on YouTube and all major podcast hosts including Spotify.CLOWNFISH TV is an independent, opinionated news and commentary podcast that covers Entertainment and Tech from a consumer's point of view. We talk about Gaming, Comics, Anime, TV, Movies, Animation and more. Hosted by Kneon and Geeky Sparkles.Get more news, views and reviews on Clownfish TV News - https://more.clownfishtv.com/

Benny Chen is the cofounder of Fireworks AI, an AI infrastructure platform. They have raised $327M in funding from Benchmark, Sequoia, Lightspeed, Index, and others. Benny's favorite book: Principles (Author: Ray Dalio)(00:01) Intro and why AI infrastructure is having a moment(00:06) Training vs inference: what's working and where the real bottlenecks are(01:25) Why inference is the hard problem in production(03:30) What breaks at scale when AI systems hit real users(05:29) GPUs, hardware constraints, and why power is now a first-class concern(06:02) What you're actually paying for in inference(07:21) Reliability, compliance, and enterprise expectations(09:49) Training and inference capacity: when they blur together(11:06) How to make inference fast in practice(13:06) System design choices behind modern inference platforms(15:28) Inference economics and cost tradeoffs(18:02) When fine-tuning actually makes sense(21:58) What “best model” really means for real companies(24:25) Production LLM architectures that actually work(27:46) Building an AI infra company customers can trust(29:27) Shipping fast without breaking reliability(31:14) Go-to-market lessons for infra startups(34:17) Where inference platforms are heading next(36:32) Rapid fire round--------Where to find Benny Chen: LinkedIn: https://www.linkedin.com/in/benny-yufei-chen-2238575a/--------Where to find Prateek Joshi: Website: https://prateekj.com Research Column: https://www.infrastartups.comLinkedIn: https://www.linkedin.com/in/prateek-joshi-infiniteX: https://x.com/prateekj

We share our feelings about Moltbook, a Reddit-like site for AI agents from popular AI assistant platform OpenClaw. Komei asked what steps any of us have taken to make provisions for our accounts after we die. And the Information reports Nvidia will not be introducing any new GPUs in 2026. Is this the final nail in the coffin for the DIY PC enthusiast hobby? Starring Sarah Lane, Tom Merritt, Robb Dunewood, Len Peralta, Roger Chang, Joe. To read the show notes click here! Support the show on Patreon by becoming a supporter!

Join us LIVE on Mondays, 4:30pm EST.A weekly Podcast with BHIS and Friends. We discuss notable Infosec, and infosec-adjacent news stories gathered by our community news team.https://www.youtube.com/@BlackHillsInformationSecurityChat with us on Discord! - https://discord.gg/bhis

Crunchyroll raises prices, Spotify launches Page Match for books, and Valve delays Steam Machine due to component shortages. NVIDIA cancels new GPUs. The post Entertainment 2.0 #702 – Component Shortages & Spotify’s Physical Book Push appeared first on The Digital Media Zone.

AI is changing the data center—but not always in the ways enterprises expect. In this episode, Keith Townsend is joined by Intel's Lynn Comp for Part Two of their conversation, shifting the focus squarely to AI infrastructure realities. They explore why many AI workloads never justify GPUs, how CPU-based deployments often exceed real [...]

This week's tech earnings feature names like Palantir (PLTR), Alphabet (GOOGL) and Amazon (AMZN) among many others. Steven Dickens stops by the Morning Movers NYSE desk to underline his focal points for these companies as they adapt to ongoing AI adoption. They try to answer the question: Do markets want aggressive A.I. capex spend? Steven says GPUs being built now are going online "right away" and demand is here now.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Nathan Lambert and Sebastian Raschka are machine learning researchers, engineers, and educators. Nathan is the post-training lead at the Allen Institute for AI (Ai2) and the author of The RLHF Book. Sebastian Raschka is the author of Build a Large Language Model (From Scratch) and Build a Reasoning Model (From Scratch). Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep490-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/ai-sota-2026-transcript CONTACT LEX: Feedback – give feedback to Lex: https://lexfridman.com/survey AMA – submit questions, videos or call-in: https://lexfridman.com/ama Hiring – join our team: https://lexfridman.com/hiring Other – other ways to get in touch: https://lexfridman.com/contact SPONSORS: To support this podcast, check out our sponsors & get discounts: Box: Intelligent content management platform. Go to https://box.com/ai Quo: Phone system (calls, texts, contacts) for businesses. Go to https://quo.com/lex UPLIFT Desk: Standing desks and office ergonomics. Go to https://upliftdesk.com/lex Fin: AI agent for customer service. Go to https://fin.ai/lex Shopify: Sell stuff online. Go to https://shopify.com/lex CodeRabbit: AI-powered code reviews. Go to https://coderabbit.ai/lex LMNT: Zero-sugar electrolyte drink mix. Go to https://drinkLMNT.com/lex Perplexity: AI-powered answer engine. Go to https://perplexity.ai/ OUTLINE: (00:00) – Introduction (01:39) – Sponsors, Comments, and Reflections (16:29) – China vs US: Who wins the AI race? (25:11) – ChatGPT vs Claude vs Gemini vs Grok: Who is winning? (36:11) – Best AI for coding (43:02) – Open Source vs Closed Source LLMs (54:41) – Transformers: Evolution of LLMs since 2019 (1:02:38) – AI Scaling Laws: Are they dead or still holding? (1:18:45) – How AI is trained: Pre-training, Mid-training, and Post-training (1:51:51) – Post-training explained: Exciting new research directions in LLMs (2:12:43) – Advice for beginners on how to get into AI development & research (2:35:36) – Work culture in AI (72+ hour weeks) (2:39:22) – Silicon Valley bubble (2:43:19) – Text diffusion models and other new research directions (2:49:01) – Tool use (2:53:17) – Continual learning (2:58:39) – Long context (3:04:54) – Robotics (3:14:04) – Timeline to AGI (3:21:20) – Will AI replace programmers? (3:39:51) – Is the dream of AGI dying? (3:46:40) – How AI will make money? (3:51:02) – Big acquisitions in 2026 (3:55:34) – Future of OpenAI, Anthropic, Google DeepMind, xAI, Meta (4:08:08) – Manhattan Project for AI (4:14:42) – Future of NVIDIA, GPUs, and AI compute clusters (4:22:48) – Future of human civilization

Linktree: ⁠https://linktr.ee/Analytic⁠Join The Normandy For Additional Bonus Audio And Visual Content For All Things Nme+! Join Here: ⁠https://ow.ly/msoH50WCu0K⁠In the Notorious Mass Effect segment, Analytic Dreamz dives deep into the RAM Price Crisis (2025–2026), unpacking the key data, market drivers, and real consumer impact behind the dramatic surge in memory costs.RAM prices have skyrocketed into a sustained inflation cycle heading into 2026, fueled by explosive AI data center demand that prioritizes high-bandwidth memory (HBM) and diverts supply from consumer DRAM. Manufacturing bottlenecks, limited cleanroom capacity, and lithography constraints exacerbate the shortage, while major players like Micron exit consumer RAM sales (Crucial brand in December 2025) to focus on higher-margin AI segments. Samsung and SK hynix report massive profit surges amid the boom.DDR5 RAM has seen prices more than quadruple (+340–344%) since July 2025, with a +27% month-on-month jump from December to January 2026. DDR4 and older standards are rising even faster recently (+46% MoM in January), narrowing the gap with newer tech. ComputerBase's fixed-basket analysis confirms average prices have quadrupled versus September 2025, with Germany's retail tracking—Europe's largest PC hardware market—mirroring global trends, including growing secondary-market distortions.Secondary effects hit related components hard: SSDs up +79%, hard drives +53%, GPUs +14% (with street prices far exceeding MSRP on models like RTX 5070 Ti). Specific examples include 2TB NVMe drives jumping 60–159% and NAS HDDs doubling.Analyst forecasts from TrendForce and Omdia point to +50–60% DRAM contract price hikes in Q1 2026, following 40–70% YoY increases in 2025. PC shipments grew +9.2% in 2025 but face potential declines in 2026, while smartphone output forecasts drop ~20% for some brands, risking +30% price hikes or spec downgrades. Gaming consoles may see delays or higher launch prices.Apple's upgrade costs (e.g., $400 for 16GB→32GB) already outpace comparable DDR5 sticks, with M6 Macs potentially facing steeper hikes or supply delays if AI firms continue outbidding.The core takeaway: This AI-driven structural shift has quadrupled RAM prices in under six months, with volatility persisting through 2026. A plateau is the most optimistic scenario—no full reversal in sight. Analytic Dreamz breaks down the data, root causes, and widespread ripple effects across PCs, smartphones, and beyond.Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/donationsPrivacy & Opt-Out: https://redcircle.com/privacy

Episode 95: The Ryzen 7 9850X3D has been released and at best all we can say about it is that it's inoffensive. Also, more reports have emerged that signal the end of GPUs at MSRP.CHAPTERS00:00 - Intro00:26 - So The 9850X3D Has Been Released16:04 - More GPU Supply Information29:40 - Zotac Might Be In Trouble43:11 - Intel Launching Big Battlemage for Pros?49:09 - Updates From Our Boring LivesSOURCESder8auer video: https://www.youtube.com/watch?v=0lS1S_VhUK4&pp=2AYBZotac Korea statement: https://videocardz.com/newz/zotac-korea-warns-of-steep-rtx-5090-and-rtx-5060-price-hikes-says-some-models-may-be-unavailable-for-a-whileArc Pro B70: https://x.com/SquashBionic/status/2015648577511629092SUBSCRIBE TO THE PODCASTAudio: https://shows.acast.com/the-hardware-unboxed-podcastVideo: https://www.youtube.com/channel/UCqT8Vb3jweH6_tj2SarErfwSUPPORT US DIRECTLYPatreon: https://www.patreon.com/hardwareunboxedLINKSYouTube: https://www.youtube.com/@Hardwareunboxed/Twitter: https://twitter.com/HardwareUnboxedBluesky: https://bsky.app/profile/hardwareunboxed.bsky.social Hosted on Acast. See acast.com/privacy for more information.

WANTED: Developers and STEM experts! Get paid to create benchmarks and improve AI models. Sign up for Alignerr using our link: https://alignerr.com/?referral-source=briankeating One of the most powerful AI systems we've ever built is succeeding for reasons we still don't understand. And worse, they may succeed for reasons that might lock us into the wrong future for humanity. Today's guest is Anil Ananthaswamy, an award-winning science writer and one of the clearest thinkers on the mathematical foundations of machine learning. In this conversation, we're not just talking about new demos, incremental improvements, or updates on new models being released. We're asking even harder questions: Why does the mathematics of machine learning work at all? How do these models succeed when they suffer from problems like overparameterization and lack of training data? And are large language models revealing deep structure, or are they just producing very convincing illusions and causing us to face an increasingly AI-slop-driven future? KEY TAKEAWAYS 00:00 — Book explores why ML works through math 02:47 — Perceptron proof shows simple math guarantees learning 05:11 — Early AI failed due to single-layer limits 07:12 — Nonlinear limits caused the first AI winter 09:04 — Backpropagation revived neural networks 10:59 — GPUs + big data enabled deep learning 15:25 — AI success risks technological lock-in 17:30 — LLMs lack human-like learning and embodiment 22:57 — High-dimensional spaces power ML behavior 27:36 — Data saturation may slow future gains 31:11 — Continual learning is still missing in AI 33:46 — Neuromorphic chips promise energy efficiency 41:49 — Overparameterized models still generalize well 45:05 — SGD succeeds via randomness in complex landscapes 48:27 — Perceptrons remain the core of modern neural net - Additional resources: Anil's NEW Book "Why Machines Learn: The Elegant Math Behind Modern AI": https://www.amazon.com/Why-Machines-Learn-Elegant-Behind/dp/0593185749 Get My NEW Book: Focus Like a Nobel Prize Winner: https://www.amazon.com/dp/B0FN8DH6SX?ref_=pe_93986420_775043100 Please join my mailing list here