Podcasts about Wanted

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    Best podcasts about Wanted

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    Latest podcast episodes about Wanted

    The Ten Minute Bible Hour Podcast - The Ten Minute Bible Hour
    PLMN049 - Nobody Wanted to Be on That Bus, But If You Had to, I Was In the Seat You'd Want

    The Ten Minute Bible Hour Podcast - The Ten Minute Bible Hour

    Play Episode Listen Later Dec 25, 2025 15:20


    Philemon You might like to get some copies of The Lightning-Fast Field Guide to the Bible for yourself and for others - here's a link that gets TMBH a little kickback: https://amzn.to/4pEYSS9Thanks to everyone who supports TMBH at patreon.com/thetmbhpodcastYou're the reason we can all do this together!Discuss the episode hereMusic by Jeff Foote

    The Exam Room by the Physicians Committee
    Best of 2025: Fiber, Cholesterol & Microplastics — What Everyone Wanted to Know

    The Exam Room by the Physicians Committee

    Play Episode Listen Later Dec 24, 2025 42:53


    What if the most-watched health topics of 2025 could help you live healthier, longer, and with more control over your body? This Best of The Exam Room Podcast 2025 compilation brings together the three pisodes that viewers couldn't stop watching — because they tackled problems that affect nearly everyone: ✔️ High cholesterol ✔️ Low fiber intake ✔️ Exposure to microplastics This episode features highlights from separate interviews with Chuck Carroll and Dr. Michael Greger, Dr. Danielle Belardo, and Dr. Hana Kahleova — the conversations that delivered the most practical, science-backed value to viewers in 2025.

    Todd N Tyler Radio Empire
    12/23 2-1 No One Wanted the Middle Seat

    Todd N Tyler Radio Empire

    Play Episode Listen Later Dec 23, 2025 12:30


    Well, not the one next to Tyler, at least.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Lowe Down with Kevin Lowe
    #425: He Had the Dream Job, the Money, and the Life Everyone Wanted—So Why Did He Walk Away? #FanFav

    The Lowe Down with Kevin Lowe

    Play Episode Listen Later Dec 23, 2025 66:09 Transcription Available


    What happens when the dream life you've spent decades building feels more like a nightmare you can't wake up from?Today's conversation is for the person who looks successful on the outside... but feels quietly disconnected on the inside. If you've ever wondered:Why do I feel empty when everything looks “right”?Why am I exhausted by a life I'm supposed to be proud of?Why does walking away feel both terrifying and necessary?This episode will hit close to home.What This Episode Is Really AboutIn this deeply honest conversation, I sit down with Matthew Blades—a former nationally syndicated radio host who spent 28 years living the dream so many people chase.The career.The money.The recognition.The life everyone else wanted.And yet… it nearly cost him everything.This is the story of what happens when success stops being enough, when your body forces you to listen, and when the bravest move forward is the one that looks like quitting from the outside.But make no mistake—this isn't a story about giving up.It's a story about waking up.Inside This Conversation, We Explore:What it feels like to succeed publicly while quietly falling apartThe moment your body starts screaming what your mind has been ignoringWhy panic attacks, burnout, and chronic stress are often messages—not malfunctionsThe difference between building a life and living oneWhat it really means to “blow up what you built” without destroying yourselfHow generational patterns, unhealed trauma, and outdated beliefs quietly shape our decisionsWhy the hardest conversations are often the most freeing onesHow to walk away from an identity you've worn for decades—and rebuild from truthIf You're Listening Right Now…This episode isn't asking you to quit your job.It's asking you to listen to yourself.To notice the quiet signals you've been explaining away.To question whether the life you're maintaining is still the life you want.To consider that walking away doesn't mean you failed—it may mean you finally chose yourself.You don't need to have all the answers.You just need the courage to ask the right questions.One Final ThoughtIf this conversation stirred something in you... Don't rush to quiet it. That discomfort might be clarity knocking. And sometimes, the bravest thing you can do is stop pretending everything is fine.Hey, it's Kevin!I hope you enjoyed today's episode! If there is ever anything I can do for you, please don't hesitate to reach out. Below, you will find ALL the places and ALL the ways to connect!I would LOVE to hear from you! Send me a Voice MessageWant to be a guest on GRIT, GRACE, & INSPIRATION? Send Kevin Lowe a message on PodMatch!Book Kevin to Speak at Your Next Event: CLICK to Learn More + Get In TouchHire Kevin to Create Your Own Custom Soundtrack!Or for 1 Place for Everything, CLICK to visit the website!Stay Awesome! Live Inspired!© 2025 Grit, Grace, & Inspiration ...

    Blízká setkání
    Výtvarnice oblékala Angelinu Jolie i Crowea: Když přijdou do kostymérny, jsou za chvíli v trenkách

    Blízká setkání

    Play Episode Listen Later Dec 23, 2025 33:55


    „Angelina Jolie je věcná a ví, co chce. Když vidí, že vaše myšlenka má směr, tak ho následuje. Ví, co chce,“ popisuje svou zkušenost s hollywoodskou hvězdou kostýmní výtvarnice. Na thrilleru Wanted spolupracovala přímo s Jolie a vzpomíná na profesionální a jasnou komunikaci. Úplně jinak, ale neméně hezky, mluví o Keanu Reevesovi: „Je velmi milý, až andělský,“ popisuje Stáňa Šlosserová v rozhovoru s Terezou Kostkovou.Všechny díly podcastu Blízká setkání můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

    Dvojka
    Blízká setkání: Výtvarnice oblékala Angelinu Jolie i Crowea: Když přijdou do kostymérny, jsou za chvíli v trenkách

    Dvojka

    Play Episode Listen Later Dec 23, 2025 33:35


    „Angelina Jolie je věcná a ví, co chce. Když vidí, že vaše myšlenka má směr, tak ho následuje. Ví, co chce,“ popisuje svou zkušenost s hollywoodskou hvězdou kostýmní výtvarnice. Na thrilleru Wanted spolupracovala přímo s Jolie a vzpomíná na profesionální a jasnou komunikaci. Úplně jinak, ale neméně hezky, mluví o Keanu Reevesovi: „Je velmi milý, až andělský,“ popisuje Stáňa Šlosserová v rozhovoru s Terezou Kostkovou.

    Weird AF News
    School puts kids in a "Time Out" box as punishment. Hundreds attend a mock funeral for the penny in DC.

    Weird AF News

    Play Episode Listen Later Dec 22, 2025 21:56


    Hundreds attend a mock funeral for the penny in Washington DC. Parents are outraged after a Canadian elementary school uses a Time Out Box on the kids. Wanted man jumped into a nativity scene to hide from the police. // Weird AF News is the only daily weird news podcast in the world. Weird news 5 days/week and on Friday it's only Floridaman. SUPPORT by joining the Weird AF News Patreon http://patreon.com/weirdafnews - OR buy Jonesy a coffee at http://buymeacoffee.com/funnyjones Buy MERCH: https://weirdafnews.merchmake.com/ - Check out the official website https://WeirdAFnews.com and FOLLOW host Jonesy at http://instagram.com/funnyjones - wants Jonesy to come perform standup comedy in your city? Fill out the form: https://docs.google.com/forms/d/e/1FAIpQLSfvYbm8Wgz3Oc2KSDg0-C6EtSlx369bvi7xdUpx_7UNGA_fIw/viewform

    I'm On the Phone with Kacey K
    118: DEBBY RYAN WANTED TO MAKE HISTORY. AND THAT'S WHAT SHE DID

    I'm On the Phone with Kacey K

    Play Episode Listen Later Dec 22, 2025 53:05


    In this episode, Kacey shares personal updates, discusses favorite Christmas movies, and reflects on the year. He dives into TV shows and movie recommendations, updates on reality TV and celebrity news, and celebrates Taylor Swift's 36th birthday by sharing his favorite songs. The conversation also touches on the upcoming Magic Treehouse series and Martha Stewart's new prefab homes, concluding with holiday wishes for listeners.

    Grace Free Church Talks
    You Wanted Luxury, But You Got Lowly (The Gift You Didn't Ask For)

    Grace Free Church Talks

    Play Episode Listen Later Dec 21, 2025 30:00


    The Christmas story didn't start with luxury or polish — it started in a messy, inconvenient, lowly place. Mary and Joseph make this exhausting trip, arrive with zero comfort waiting for them, and Jesus is literally laid in a feeding trough because there's no guest room. And the point isn't “wow, that's unfortunate.” The point is: it was intentional. From the very beginning, Jesus shows us what He's like — humble, not flashy; purposeful even when it doesn't make sense; and close enough that anyone can come near. If life feels messy or disappointing right now, that's not a sign you're disqualified — it's exactly the kind of place Jesus steps into. Faith doesn't avoid the mess — it finds Jesus in it. Your faith was made for the mess. (Talk by Josh Daubert)

    Rejoice in the Lord Video
    Just What They Wanted for Christmas

    Rejoice in the Lord Video

    Play Episode Listen Later Dec 21, 2025 34:36


    Just What They Wanted for Christmas (broadcast date: 12/21/2025)

    Weird Darkness: Stories of the Paranormal, Supernatural, Legends, Lore, Mysterious, Macabre, Unsolved
    The Ghostly Spirit Behind the Script Wanted His Name on the Marquee, Not Hers

    Weird Darkness: Stories of the Paranormal, Supernatural, Legends, Lore, Mysterious, Macabre, Unsolved

    Play Episode Listen Later Dec 20, 2025 307:53 Transcription Available


    In “The Imposter”, a woman, despite having no theatrical background, is suddenly inspired to write a full-length play — with the ghostly help of a long-dead actor. When the play turns out to be a hit, she tries to take all the credit for it. But the real author's spirit isn't having it and demands that her name be removed from the marquee.  | #RetroRadio EP0571CHAPTERS & TIME STAMPS (All Times Approximate)…00:00:00.000 = Show Open00:01:30.028 = CBS Radio Mystery Theater, “The Imposter” (March 22, 1977) ***WD00:45:34.027 = Eleventh Hour, “Will” (1941-1946) ***WD01:14:24.935 = Escape, “Red Wine” (February 26, 1949)01:43:51.535 = Everyman's Theater, “This Precious Freedom” (October 04, 1940) ***WD02:11:07.323 = Murder By Experts, “Murder By Prescription” (July 11, 1949)02:40:34.581 = Exploring Tomorrow, “The Last Doctor” (February 19, 1958)02:59:01.191 = Faces in The Window, “Lightning Rod Man” (January 17, 1953) ***WD (LQ)03:22:41.516 = Dark Fantasy, “Debt From The Past” (January 16, 1942)03:46:52.517 = Fear on 4, “The Chimes of Midnight” (October 02, 1997) ***WD04:14:52.809 = 5 Minute Mysteries, “Broken Window” (1947-1950)04:19:55.490 = Tales From The Tomb, “Don't Drink With Strangers” (1960s)04:23:35.238 = BBC Ghosts From The Past, “The Boat Hook” (April 15, 1992)05:07:02.739 = Show Close(ADU) = Air Date Unknown(LQ) = Low Quality***WD = Remastered, edited, or cleaned up by Weird Darkness to make the episode more listenable. Audio may not be pristine, but it will be better than the original file which may have been unusable or more difficult to hear without editing.Weird Darkness theme by Alibi Music LibraryABOUT WEIRD DARKNESS: Weird Darkness is a true crime and paranormal podcast narrated by professional award-winning voice actor, Darren Marlar. Seven days per week, Weird Darkness focuses on all thing strange and macabre such as haunted locations, unsolved mysteries, true ghost stories, supernatural manifestations, urban legends, unsolved or cold case murders, conspiracy theories, and more. On Thursdays, this scary stories podcast features horror fiction along with the occasional creepypasta. Weird Darkness has been named one of the “Best 20 Storytellers in Podcasting” by Podcast Business Journal. Listeners have described the show as a cross between “Coast to Coast” with Art Bell, “The Twilight Zone” with Rod Serling, “Unsolved Mysteries” with Robert Stack, and “In Search Of” with Leonard Nimoy.= = = = ="I have come into the world as a light, so that no one who believes in me should stay in darkness." — John 12:46= = = = =WeirdDarkness® is a registered trademark. Copyright ©2025, Weird Darkness.= = = = =#ParanormalRadio #ScienceFiction #OldTimeRadio #OTR #OTRHorror #ClassicRadioShows #HorrorRadioShows #VintageRadioDramas #WeirdDarknessCUSTOM WEBPAGE: https://weirddarkness.com/WDRR0571

    LSAT Unplugged
    If I Wanted A 175+ LSAT Score in January 2026, This is What I'd Do

    LSAT Unplugged

    Play Episode Listen Later Dec 20, 2025 6:18


    Frame Your Way to Five Figures Photography Podcast
    What I'd Do Differently If I Wanted More Bookings This January (30 Day Marketing Challenge)

    Frame Your Way to Five Figures Photography Podcast

    Play Episode Listen Later Dec 19, 2025 4:05


    Hey friend—this is a quick bonus episode, and I'll keep it short and to the point.If you're listening to this and thinking, “January is usually slow for me” or “I really want this year to be different in my business,” I made something specifically for you.Then it's time to join the free 30 Day Marketing Challenge kicking off January 2nd, 2026. You can sign up here.  ________________________________________________________________________________________Start the new year strong with my 30-Day Marketing Challenge for Photographers! We kick off on Friday January 2nd. Each day, you'll get a quick marketing action to help you get seen, book more clients, and build momentum — all sent straight to your inbox. Sign up here - https://brookejefferson.com/challenge

    The Filipino American Woman Project
    183: "Being bullied sucked." — A Filipina Who Just Wanted to Survive Her Childhood

    The Filipino American Woman Project

    Play Episode Listen Later Dec 19, 2025 26:33


    If you could reflect on one thing, it's this:Which memories define you, or don't define you anymore?This letter is for anyone who simply wants to feel safe, secure, and stable in her friendships.Through a flashback sparked by a new friend around a bonfire, the writer recalls a time when she was bullied, labeled “lesser than,” and ambushed by a group of girls who she thought were her people.If you ever struggled to defend yourself for something you didn't do, this one's for you.Join us for our FINAL Family Potluck: Vision Board Workshop this Monday, December 22nd! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.tfawletters.com/subscribe

    The Player Development Pod presented by Beyond the Field
    If I Wanted to Go From Assistant to Director in One Year, Here's What I'd Do

    The Player Development Pod presented by Beyond the Field

    Play Episode Listen Later Dec 19, 2025 13:07


    If you are an assistant in player development and your goal is to become a Director, this episode will give you clarity on what actually matters.In Day 8 of the 12 Days of Player Development, I walk through what I would focus on if I wanted to go from assistant to director in one year.This is not about rushing the process.It is about preparing for the responsibility that comes with leadership.We talk about:Why being inside the building is your biggest advantageHow mastering your role creates leverage and trustWhat assistants need to understand about organizational structureHow mentorship accelerates readinessWhy thinking like a director before you become one mattersIf you are serious about developing people and elevating programs, this conversation will help you evaluate where you are and what to do next.BOOK - Get YOUR copy of the Beyond The Field Player Development Guide: https://amzn.to/3TtnaA8 2026 Player Development Summit - https://www.btfprogram.com/pdsummit2026 Player Development Summit Sponsorship - https://forms.gle/vPucKVKaZmTVcLDq9Player Development Newsletter → https://substack.com/@btfprogram

    FBI Retired Case File Review
    381: William Peterson – Kenya Kidnapping, Most Wanted Terrorist Sajid Mir

    FBI Retired Case File Review

    Play Episode Listen Later Dec 18, 2025 62:02


    Retired agent William Peterson reviews two cases, his kidnapping investigation where two American businessmen in Kenya where held for ransom and his assistance in the capture and identification of terrorist Sajid Mir, a senior member of the Pakistan-based Foreign Terrorist Organization (FTO) Lashkar-e-Tayyiba (LeT). Mir is on the FBI Most Wanted list for his leading role in the planning, preparation, and execution of the November 2008 terrorist attacks in Mumbai, India. These were just two of the significant investigations Peterson worked during his FBI counterterrorism and international law enforcement career. He served in the FBI for 23 years. Check out episode show notes, photos, and related articles: https://jerriwilliams.com/381-william-peterson-kenya-kidnapping-most-wanted-terrorist-sajid-mir/       Join my Reader Team to get the FBI Reading Resource - Books about the FBI, written by FBI agents, the 20 clichés about the FBI Reality Checklist, and keep up to date on the FBI in books, TV, and movies via my monthly email. Join here. http://eepurl.com/dzCCmL        Buy me a coffee - https://www.buymeacoffee.com/JerriWilliams     Check out my FBI books, non-fiction and crime fiction, available as audiobooks, ebooks and paperbacks wherever books are sold. https://jerriwilliams.com/books/

    The Badass Counseling Show
    I Just Wanted Love

    The Badass Counseling Show

    Play Episode Listen Later Dec 18, 2025 55:39


    Here is an inspiring counseling session with Becker, whose anger about his dad leaving when he was 5 has affected his whole life. Now in his 50s and on the verge of divorce, he's doing the healing work that paves the way to a better, lighter life. Sven helps him find his way. Explicit content.Send us a text

    The Art of Living Big | Subconscious | NLP | Manifestation | Mindset

    In this episode of ‘The Art of Living Big,’ Betsy helps us focus on the present moments in our lives. She reminds us to emphasize the cozy, reflective moments amidst holiday preparations, to fully “wear our lives” by making conscious choices for ourselves. Betsy clues us into the powerful messages in our dreams; metaphors produced by our unconscious mind that we can learn from. She concludes with a message of hope for the new year and an invitation to embrace our true potential. Transcript:  Welcome to The Art of Living Big, where we explore how to live intentionally and with more joy. I’m Betsy Pake, your host, master, coach, and creator of the Navigate Method. Here to help you listen in to your true desires, elevate your standards, and live life to the fullest. Now, let’s go live big. Hi, everybody. Welcome. Welcome to the show today. It’s our last show before the holiday, so I hope everybody’s ready. I hope you’re getting some time to decompress. I know the last couple weeks it’s been cold here in Atlanta, like super cold, and I have had. Twinkly lights. I feel like I’ve got my decorations just right. , I haven’t turned on an overhead light in weeks. It feels so nice and cozy. I actually have really been enjoying it, being really chilly out. I don’t know, just I’m in the top floor of my apartment, which I like to call the penthouse and. I can really hear the wind because I’m right , on the corner, but I really love it. The other day , it was like a, it was Saturday, I think. Saturday or Sunday. It was so windy here, so, so, so windy. You could just hear the wind whipping outside. And I was like, this is a perfect conditions for a nap. And yeah, so I just took a nap and I could hear the wind and it was just kind of magical. I grew up in Vermont, you know, I live in Atlanta, but I grew up in Vermont. So anyway, I attribute my love of the cozy to that experience, I guess. . So I’m excited to be here with you today. , Just a reminder, next month we have a fireside chat. It’s January 11th. I’m really gonna try and do these every month, and it’s just a free time for everybody to come together on Zoom, you can sign up by going to my Instagram. The link is gonna be in my bio, but you can also just message me, fire and it will automatically send you the link to get signed up. , We did this in November and it was really so nice to have everybody come together and it was nice to see some of my old clients and favorite people. And we just talked about midlife and some of the challenges. I’ve got some thoughts for this time. Last time was very unscripted, which this time will be two. I mean, I wanna just go with the flow of what everybody needs, but. Wanted to invite you to join us. I know last week, I don’t know, every week probably, I’m talking about that quilted house coat from Cozy Earth and Cozy Earth’s one of our sponsors here on the podcast, but I’m obsessed with my quilted house coat and they’ve sold out. , I’m so sorry if anybody didn’t get theirs, still get it in January. The code live big Betsy. That’ll still get you 20% off like any time of the year. But those are just so great. I’m not surprised it sold out. One of my very best friends was waiting to get one and she was gonna have that be her Christmas gift. And when she went to go buy it, they were completely sold out. I actually looked last night, the night before and they just had extra, extra large. , And if you look at the size and guide, I think they’re pretty. Pretty true to size. So , I was like, get the extra, extra large and then just return it so you get the super discount. But it’s, so good. But I wanna remind you also that they have those cozy lounge socks. Those are great stocking stuffers, so don’t sleep on those. ’cause , I think when I looked at the other night, it was like 30% off on the website and then the live Big Betsy code gets you an additional 20%. So it’s a huge difference. And those stocks are lovely. So. Just wanted to shout out Cozy Earth and remind you guys, I know I’m gonna wear , my bathrobe , to the fireside chat. I have no shame. I love that thing, so I will show up in that. , But I’m really excited to see everybody, so hopefully you’ll be able to make it. All right. So today, okay, so this is kind of a vulnerable thing, but , I, I wanted to share something because I. I talk a lot on the show about unconscious change and how we show up in the world and , a little bit of magic. I think. I love a little bit of magic in the universe and , one of the things that I have done for years is I use a journal on my iPad called Day One. You’ve probably heard me talk about this before, but it is a online journal. It’s an app on my phone and on my iPad. I use it on my iPad. I’ve used it for, I don’t know, probably 12 years, maybe more. And I love this thing because it’s easy. I like, , we continue to do things that are simple, right, and easy. And it gives me a chance in the morning to just sort of like. Data dump, like everything that’s on my mind and whenever I have a dream that was really vivid, I like to write it out with all the detail that I can remember. And I find this really helpful because it helps me remember the dream and I can think about it later and figure out what this means. But also one of the cool things about this journal is it’ll tell me like, this is what you said last year, this is what you said three years ago, 10 years ago. And , sometimes we forget. How much we’ve grown or how much we’ve changed unless it’s right in front of us, , unless it’s like something that we can actually see to compare. And I think we all have this habit, I’m gonna say like a really bad habit where we’re looking forward, right? These are the things I wanna experience. This is what I wanna have in my life. These are the things not working. And so when we’re comparing it to the future, it appears as. Lack, it appears as absence because we’re not where we wanna be, but when we have a chance to reflect and to say, look at where I was and now look where I am. It might be where you are physically, it might be where you live. It might be goals you’ve reached. It might just be, I am shifting and changing and I’m moving forward. And there were years where I would look back at a year ago, two years ago, and I would say to myself, oh my God, , I’m talking about the same exact things. Like I feel like I haven’t changed or grown at all. Like when am I gonna get. Unstuck. But the truth now that I can see when there’s been a little bit more space, and I can look back, I can see that this is actually like turtle, right? Like a turtle. Like little tiny shifts moving me in the direction that I want. And that’s really, really important. So what I wanna do is I wanna talk about a dream that I had last year. So it was right around this time last year and I was on that day that I was taking that little nap. It was so windy, windy out, and I opened my journal and I wrote it in my journal, and then I was like, I’m gonna take a little nap. But in my journal, I looked back and then sometimes I’ll look back at the year before or two years before, but then I’ll look at days surrounding it, you know? I’m like, what was going on? Just so I can remember. And. I had a dream last year and I wanna tell you about this dream. And it’s not because I think dreams are, , mystical or predictive in some like woo woo way, but it’s because I have learned both personally and professionally that when something inside you knows the truth before you are ready to face it. It often speaks to us through our unconscious, and our unconscious speaks to us in metaphor. And so this dream actually happened in one of the final months that I was still living in the same house as my now former husband. And the timing of that really matters because emotionally, , the relationship was over. We were trying to sell the house. It took quite a while, and so we were living in close proximity, but. The relationship was over. My nervous system knew it , just that my body was still there. And when you live like that for too long, right? When your inner world and your outer life are out of sync, something starts trying to get your attention. And so in this dream, I was at the airport. Now I wanna share this dream because, and I’m gonna relate it back , to you and why this. Could be helpful. Okay, so I’m at the airport. It’s not a normal airport though. It’s , packed, like wall to wall to wall people. So as far as you could see, like a sea of people. And , you’re in a crowd, so there’s just, you’re not really walking regular. You’re like shuffling. You know that feeling. So I get this feeling that everyone’s moving really fast. Like everybody is going someplace. They know where they’re going and they’re all. Moving and bumping into me. So I’m like, goochie, goochie, goochie. And they’re bumping into me and I feel like I am not able to actually take a step forward. And , airports are in between places, right? You’re not where you were and you’re not yet where you’re going. You’re in this like in-between place. And that is exactly where I was in my life at that time. So. In this dream. I was traveling with him, but I wasn’t walking beside him. I was following him. So he was like way ahead of me, completely unaware that I was even there just doing his thing, right? He just kept moving forward and I was getting pushed around, like losing my footing, trying to keep up, and in my dream he never turned around and that’s the image that I remember. I remember feeling like I was. Almost a kid getting lost in the shuffle, ? And I, think that experience of my life at that time is reflected in that dream, because that’s where their relationship was , at that time. I, felt like. I was orienting around him, like tracking him or adjusting to him. And when you live that way long enough, , you lose your own internal compass. And at some point in the dream, I realized that I had a backpack that was gone. So I wasn’t carrying the backpack on my shoulders. I had been holding it like by the top straps. You know how sometimes backpacks have that little handle? So I was holding it by that, so it was like an accessory. So at the moment that I realized I was missing the backpack is the same moment that I realized I actually had been carrying a backpack, if that makes sense. And then I looked down and realized it was just gone. It was like I noticed my hand first. I don’t remember setting it down. I don’t remember like choosing to let it go. I just looked down and it was missing, and I think that’s how this actually happens. Like we don’t wake up one day and decide to abandon ourselves. We adapt and we accommodate and we make it work. Until one day we look around and we think, like, where did I go? And I tried to backtrack through the crowd in my dream, and eventually I found a backpack that I thought looked like mine. It was like the same pattern, like the same kind of backpack, but it was empty and it wasn’t quite the right size. And I remember thinking in the dream, and I wrote this in my journal that I don’t even know if this is mine anymore. I think this is like such an important moment because from the outside my life looked the same. Like the same house I was, looked like the same woman. It looked like the same marriage. Right. But inside it was empty. It was empty backpack. And , I don’t think, when I look back I’m like, that wasn’t unhappiness. That was dissociation. Right. Dissociated from what was happening and in my dream, I went to the gate attendant and I told them that the only picture that I had of my mother who died when I was 16, was in that bag. It wasn’t true. I even wrote that in my journal. Like I told her a lie that the only picture I had of my mom was in that backpack because I needed her to understand how serious this felt and that I needed help and I needed somebody to see me. And so they tried and they were confused. And then eventually , the,. Gate attendant, just admitted that she couldn’t do anything. And so I just turned around and just walked away. I just decided to move on, and that is when I realized that my phone was gone too. My voice, like my connection, my ability to call for help, everything was gone. And here’s what I want you to hear in this. This dream wasn’t about my marriage. It, and I wanna say that again. He’s had a, he has his own experience of that. Like it is not about him. It’s not about my marriage. It was about my identity erosion. It was about what happens when you stay in a life that no longer fits for way too long. And I think when we talk about metaphor and , our unconscious minds speaking to us through our dreams. , That backpack was my identity. It was my needs, , my internal resources, and I wasn’t wearing it. I was carrying it by that little handle so lightly so that I could maneuver around other people. And that is what I think self abandonment actually looks like. It’s not like some big dramatic event. It’s not obvious. It’s reasonable. Subtle, and I see this all the time in my work, women who tell me that they can’t quite put their finger on it, like they feel kind of numb or lost or disconnected. And so they think , , that they’re broken, but they’re not. They’re just, I would say like disembodied. Right? And so. I wanted to share that dream because I think it’s was such a good metaphor for where so many of us are and where so many of us are, whether we’re feeling lost or dissociated from a relationship or a job, or after your kids leave to , go off to college and you’re alone for the first time. Like so many things. And so I think that when we think about. A big life, and I’m using air quotes, right? ’cause I talk about a big life. A big life isn’t some fancy living on a yacht. , That’s not what I mean by a big life. I mean, choosing yourself, right? It’s not about blowing everything up. It’s not about dramatic things. It’s , it’s not about certainty even. It’s about embodiment. Embodiment, right? It’s about. Wearing your life, that backpack, instead of carrying it so loosely that anybody could knock it out of your hand. Wearing your life means , that your values live inside your body, not just inside your head. Right? It means that when you speak and something feels off, instead of talking yourself out of it. It means you listen to it, right? It means you, you know what your yes and your no are, and that those come from inside your body, not from managing someone else’s comfort. Most people, and , I’m including myself in this, we don’t lose ourselves because of one big thing. It’s not one big event that happened. We lose ourselves because we are so great at adapting. At, making ourselves smaller to keep things calm or low maintenance or understanding. And then one day you wake up and you realize that you’ve been holding yourselves by the little tiny strap. And so. , If you’ve been struggling in your relationship or in your job or anything where you’re like, should I stay or should I go? Here’s the question that I wanna leave you with, is instead of that, I want you to ask yourself like, where am I managing my life? Instead of inhabiting it, , where am I carrying myself instead of standing in myself? , I think we can abandon ourselves in a million different ways. And, , I’ll say it again, it, had less to do with my ex-husband. It had to do with me. I was the one doing that. I was the one choosing that. And yes, there’s were circumstances around it, but in the end it was when I decided to. Fully embody myself when I decided that I was gonna put myself first, when I decided that being kind wasn’t the end all, be all that what if being kind and people saw me as being so kind. It’s not that I don’t wanna be kind to people. That’s not what I’m saying, but perhaps that was an indicator that. Yeah, I was putting everyone else first and that I didn’t always need to do that. There are times where I put my daughter first and that feels right. That is the right thing to do, and I want to do that, and there are times when I don’t. So having the discernment of that, I think is really important so that we don’t lose ourselves. Because when you can start wearing your life again, that’s when clarity comes back to you. And , this year for me, I don’t know if you saw on Instagram, but every year I give myself an award. So I order these crystal awards from Crown Awards. And this year my award was, , the Chrysalis Award This year has been. So transformative for me, not because I did some big thing or not because I, , had some big, huge success. Like it wasn’t that. It was that I started feeling really solid, that I started really leaning into my body as an oracle, that I started really trusting myself in a totally different way and hearing myself. And I stopped getting lost in that big crowd getting bumped around. So it’s not, , the art of living big isn’t about becoming louder. It is about becoming solid, right? It’s about putting your backpack back on your shoulders, fully, like strapped in with the little strap around the front. You know that clicks in that. That is how you live a big life. I hope you all have a really, really happy holiday. However you celebrate. I hope you have a hopeful New Year, and that 2026 becomes everything that you want it to be, and you get to decide. You get to decide how that goes. All right. I love you so much. I’ll see you after the new year. Thanks for joining me on The Art of Living Big. I hope today’s episode sparked something within you, maybe pushed you to dream a little bit bigger and live a little larger. Don’t forget to subscribe. Leave us a review and share this podcast with someone you know who might need a little inspiration today. You can find me over on Instagram at Betsy Pake and on my YouTube channel. Remember, the world is vast. Your potential is endless, and your life, it’s yours to shape. Until next time, keep reaching, keep exploring, and keep living big.

    McElroy and Cubelic in the Morning
    AJ McCarron, the new Birmingham Stallions head coach, tells McElroy & Cubelic why he wanted to get into coaching, how Nick Saban like his coaching style will be, and what fans should expect from the Stallions in 2026

    McElroy and Cubelic in the Morning

    Play Episode Listen Later Dec 18, 2025 18:42


    "McElroy & Cubelic In The Morning" airs 7am-10am weekdays on WJOX-94.5!See omnystudio.com/listener for privacy information.

    Hill-Man Morning Show Audio
    They Said It: Mookie never wanted to leave Boston

    Hill-Man Morning Show Audio

    Play Episode Listen Later Dec 18, 2025 17:43


    They Said It is a quick back and forth on what was said in the sports world yesterday. Today we hear from Joe Burrow, Mike McDaniel and Mookie Betts.

    Monocle 24: The Globalist
    The EU decides on Russia's assets, France's social security vote and bartenders wanted in Saudi Arabia

    Monocle 24: The Globalist

    Play Episode Listen Later Dec 18, 2025 58:07


    European leaders vote on whether to use Russia’s frozen assets to help Ukraine, France’s social security bill and the end of Air Albania. Plus: newspapers, musician Tiago Caetano and bartenders wanted in Saudi Arabia.See omnystudio.com/listener for privacy information.

    China In Focus
    China Targets Missouri Sen. Eric Schmitt in $50B Lawsuit - China in Focus

    China In Focus

    Play Episode Listen Later Dec 18, 2025 23:30


    00:00 Intro01:12 China Targets Missouri Sen. Eric Schmitt in $50B Lawsuit02:54 Wanted by CCP: Asylum Seeker Faces Deportation Risks06:16 Trump Moves to Make Peru a Major Non-NATO Ally08:00 Trump Designates Fentanyl a Weapon of Mass Destruction13:51 Up to 30 Japanese Lawmakers to Visit Taiwan14:28 Japan Sees Chinese Tourism Growth Slow to 3 percent in Nov.15:15 China Criticizes Japan at U.N., Japan Pushes Back15:46 Expert on U.S. Stakes in China-Taiwan-Japan Tensions16:53 China Flexes Military Might to Deter Japan, U.S.19:18 China Projects Confidence, Pressures Japan20:26 Fisher: China Might Escalate Tensions With U.S., Japan21:50 China Could Build a Military Base in Taiwan If Taken

    Naturally Surviving
    How I Knew I Wanted A Business

    Naturally Surviving

    Play Episode Listen Later Dec 18, 2025 15:28


    In this conversation, Dr. Lacy reflects on her journey from completing her PhD to pursuing entrepreneurship. She discusses the pressures of societal expectations, the challenges of transitioning from academia to business, and the importance of self-investment and overcoming imposter syndrome. Dr. Lacy emphasizes the need for personal growth and the value of taking risks to achieve one's dreams. Happy, Free, & Paid Membership https://qualscholars.kit.com/3c1982f79f  Dissertation Information Qual Scholars Community: https://qual-scholars.circle.so/ 10 Pages In 2 Days Writing Retreat: https://qualscholars.com/10pages/ The Finish Your Dissertation Institute: https://qualscholars.com/theinstitute/  Qual Scholars Website: https://qualscholars.com/  Qual Scholars' Instagram: https://instagram.com/qual_scholars/ Book An Astrology Reading: https://www.qualscholars.com/offers/8q2V7xF3/checkout   

    THE SYM PODCAST SHOW-2 fans , 1 sport
    NFL Week 16...No Division titles for you!! The NFL Wanted this!

    THE SYM PODCAST SHOW-2 fans , 1 sport

    Play Episode Listen Later Dec 18, 2025 73:14


    No team has bagged the division, its been a while this late in the season! Steelers and Patriots have trailers on their backs. We have NFL news, Week 15 review, Power Rankings and game picks! And of course we discussed playoff seeding!

    Iko Nini Podcast
    EP 571 THE PEOPLE SHALL vs. BLOOD PARLIAMENT: The Film RUTO Wanted BANNED!

    Iko Nini Podcast

    Play Episode Listen Later Dec 18, 2025 80:52


    EP 571 THE PEOPLE SHALL vs. BLOOD PARLIAMENT: The Film RUTO Wanted BANNED!

    The Re-Wrap
    THE RE-WRAP: A Thriving Economy! Just What I Wanted

    The Re-Wrap

    Play Episode Listen Later Dec 18, 2025 10:55 Transcription Available


    THE BEST BITS IN A SILLIER PACKAGE (from Friday's Mike Hosking Breakfast) Beats Socks/Politician of the Year/Remember Kiss Cam?/Now We're CookingSee omnystudio.com/listener for privacy information.

    The Jay Situation
    Episode 287 - Sig MCX LVAW Lessons Learned and SilencerCo Sparrow Technical Deep Dive (17-DEC-2025)

    The Jay Situation

    Play Episode Listen Later Dec 17, 2025 78:53


    Today's Topics:1. Sound Signature Review 6.208 – SilencerCo Sparrow on the subcompact Beretta 21A Bobcat. Historically significant silencer, by popular demand. Long overdue. The Sparrow was SilencerCo's first product and has enjoyed significant proliferation. Let's dive into this FRP-famous silencer, technically. This accompanies last week's report and Silencer Hazard Map Brief 8.1.6.a. Introduction (00:07:35)b. Sparrow Design (00:13:14)c. Sparrow performance (00:21:08)d. Spatial hazards (00:43:38)e. Final thoughts (00:46:57)2. The 300 BLK MCX, or Rattler LT, or LVAW, or whatever you want to call it… is really fun! Like any cool small arm weapon system, you want to make it “your own.” I am busy doing that. Wanted to share some thoughts about my own personal gun and what I have discovered I like, don't like, and how it's working for me. (00:48:59)Sponsored by - Silencer Shop, Top Gun Range Houston, Legion Athletics, Capitol Armory, and the PEW Science Laboratory!Legion Athletics: use code pewscience for BOGO off your entire first order and 20% cash back always!Magpul: Use code PSTEN to receive $10 off your order of $100 or more at Magpul

    The Tara Show
    “Kangaroo Courts & the Mar-a-Lago Setup: The Emails They Never Wanted You to See”

    The Tara Show

    Play Episode Listen Later Dec 17, 2025 10:38


    Shocking new FBI emails expose internal pushback against the Mar-a-Lago raid — and confirm what many feared: there may never have been probable cause. In this episode, Tara breaks down how a single anonymous source, DOJ overreach, and weaponized justice nearly rewrote the Constitution. Plus, why Senate Republicans blocking Trump's nominees are playing with fire — and how Susie Wiles' betrayal fits into the bigger picture.

    JCO Precision Oncology Conversations
    Podcast: FGFR3 Alteration Status and Immunotherapy in Urothelial Cancer

    JCO Precision Oncology Conversations

    Play Episode Listen Later Dec 17, 2025 18:51


    JCO PO author Dr. Shilpa Gupta at Cleveland Clinic Children's Hospital shares insights into her article, "Fibroblast Growth Factor Receptor 3 (FGFR3) Alteration Status and Outcomes on Immune Checkpoint Inhibitors (ICPI) in Patients with Metastatic Urothelial Carcinoma". Host Dr. Rafeh Naqash and Dr. Gupta discuss how FGFR3 combined with TMB emerged as a biomarker that may be predictive for response to ICPI in mUC. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Associate Professor at the OU Health Stephenson Cancer Center. Today I am excited to be joined by Dr. Shilpa Gupta, Director of Genitourinary Medical Oncology at the Cancer Institute and co-leader of the GU Oncology Program at the Cleveland Clinic, and also lead author of the JCO PO article titled "Fibroblast Growth Factor Receptor 3 Alteration Status and Outcomes on Immune Checkpoint Inhibitors in Patients With Metastatic Urothelial Carcinoma." At the time of this recording, our guest's disclosures will be linked in the transcript. Shilpa, welcome again to the podcast. Thank you for joining us today. Dr. Shilpa Gupta: Thank you, Rafeh. Honor to be here with you again. Dr. Rafeh Naqash: It is nice to connect with you again after two years, approximately. I think we were in our infancy of our JCO PO podcast when we had you first time, and it has been an interesting journey since then. Dr. Shilpa Gupta: Absolutely. Dr. Rafeh Naqash: Well, excited to talk to you about this article that you published. Wanted to first understand what is the genomic landscape of urothelial cancer in general, and why should we be interested in FGFR3 alterations specifically? Dr. Shilpa Gupta: Bladder cancer or urothelial cancer is a very heterogeneous cancer. And while we find there is a lot of mutations can be there, you know, like BRCA1, 2, in HER2, in FGFR, we never really understood what is driving the cancer. Like a lot of old studies with targeted therapies did not really work. For example, we think VEGF can be upregulated, but VEGF inhibitors have not really shown definite promise so far. Now, FGFR3 receptor is the only therapeutic target so far that has an FDA approved therapy for treating metastatic urothelial cancer patients, and erdafitinib was approved in 2019 for patients whose tumors overexpressed FGFR3 mutations, alterations, or fusions. And in the landscape of bladder cancer, it is important because in patients with non-muscle invasive bladder cancer, about 70 to 80% patients can have this FGFR3. But as patients become metastatic, the alterations are seen in, you know, only about 10% of patients. So the clinical trials that got the erdafitinib approved actually used archival tumor from local cancer. So when in the real world, we don't see a lot of patients if we are trying to do metastatic lesion biopsies. And why it is important to know this is because that is the only targeted therapy available for our patients right now. Dr. Rafeh Naqash: Thank you for giving us that overview. Now, on the clinical side, there is obviously some interesting data for FGFR3 on the mutation side and the fusion side. In your clinical practice, do you tend to approach these patients differently when you have a mutation versus when you have a fusion? Dr. Shilpa Gupta: We can use the treatment regardless of that. Dr. Rafeh Naqash: I recently remember I had a patient with lung cancer, squamous lung cancer, who also had a synchronous bladder mass. And the first thought from multiple colleagues was that this is metastatic lung. And interestingly, the liquid biopsy ended up showing an FGFR3-TACC fusion, which we generally don't see in squamous lung cancers. And then eventually, I was able to convince our GU colleagues, urologists, to get a biopsy. They did a transurethral resection of this tumor, ended up being primary urothelial and synchronous lung, which again, going back to the FGFR3 story, I saw in your paper there is a mention of FGFR3-TACC fusions. Anything interesting that you find with these fusions as far as biology or tumor behavior is concerned? Dr. Shilpa Gupta: We found in our paper of all the patients that were sequenced that 20% had the pathognomonic FGFR3 alteration, and the most common were the S249C, and the FGFR3-TACC3 fusion was in 45 patients. And basically I will say that we didn't want to generate too much as to fusion or the differences in that. The key aspect of this paper was that historically there were these anecdotal reports saying that patients who have FGFR alterations or mutations, they may not respond well to checkpoint inhibitors because they have the luminal subtype. And these were backed by some preclinical data and small anecdotal reports. But since then, we have seen that, and that's why a lot of people would say that if somebody's tumor has FGFR3, don't give them immunotherapy, give them erdafitinib first, right? So then we had this Phase 3 trial called the THOR trial, which actually showed that giving erdafitinib before pembrolizumab was not better. That debunked that myth, and we are actually reiterating that because in our work we found that patients who had FGFR3 alterations or fusions, and if they also have TMB-high, they actually respond very well to single agent immunotherapy. And that is, I think, very important because it tells us that we are not really seeing that so-called potential of resistance to immunotherapy in these patients. So to answer your question, yeah, we did see those differences, but I wouldn't say that any one marker is more prominent. Dr. Rafeh Naqash: The analogy is kind of similar to what we see in lung cancer with these mutations called STK11/KEAP1, which are also present in some other tumors. And one of the questions that I don't think has been answered is when you have in lung cancer, if you extrapolate this, where doublet or single agent immunotherapy doesn't do as well in tumors that are STK11 mutated. But then if you have a high TMB, question is does that TMB supersede or trump the actual mutation? Could that be one reason why you see the TMB-high but FGFR3 altered tumors in your dataset responding or having better outcomes to immunotherapy where potentially there is just more neoantigens and that results in a more durable or perhaps better response to checkpoint therapy? Dr. Shilpa Gupta: It could be. But you know, the patients who have FGFR alterations are not that many, right? So we have already seen that just patients with TMB-high respond very well to immunotherapy. Our last podcast was actually on that, regardless of PD-L1 that was a better predictor of response to immunotherapy. So I think it's not clear if this is adding more chances of response or not, because either way they would respond. But what we didn't see, which was good, that if they had FGFR3, it's not really downplaying the fact that they have TMB-high and that patients are not responding to immunotherapy. So we saw that regardless, and that was very reassuring. Dr. Rafeh Naqash: So if tomorrow in your clinic you had an individual with an FGFR3 alteration but TMB-high, I guess one could be comfortable just going ahead with immunotherapy, which is what the THOR trial as you mentioned. Dr. Shilpa Gupta: Yes, absolutely. And you know, when you look at the toxicity profiles of pembrolizumab and erdafitinib, really patients really struggle with using the FGFR3 inhibitors. And of course, if they have to use it, we have to, and we reserve it for patients. But it's not an easy drug to tolerate. Currently the landscape is such that, you know, frontline therapy has now evolved with an ADC and immunotherapy combinations. So really if patients progress and have FGFR3 alterations, we are using erdafitinib. But let's say if there were a situation where a patient has had chemotherapy, no immunotherapy, and they have FGFR3 upregulation and TMB-high, yes, I would be comfortable with using only pembrolizumab. And that really ties well together what we saw in the THOR trial as well. Dr. Rafeh Naqash: Going to the clinical applications, you mentioned a little bit of this in the manuscript, is combination therapies. You alluded to it a second back. Everything tends to get combined with checkpoint therapy these days, as you've seen with the frontline urothelial, pembrolizumab with an ADC. What is the landscape like as far as some of these FGFR alterations are concerned? Is it reasonable to combine some of those drugs with immune checkpoint therapy? And what are some of the toxicity patterns that you've potentially seen in your experience? Dr. Shilpa Gupta: So there was indeed a trial called the NORSE trial. It was a randomized trial but not a comparative cohort, where they looked at FGFR altered patients. And when they combined erdafitinib plus cetrelimab, that did numerically the response rates were much higher than those who got just erdafitinib. So yeah, the combination is definitely doable. There is no overlapping toxicities. But unfortunately that combination has not really moved forward to a Phase 3 trial because it's so challenging to enroll patients with such kind of rare mutations on large trials, especially to do registration trials. And since then the frontline therapy has evolved to enfortumab vedotin and pembrolizumab. I know there is an early phase trial looking at a next generation FGFR inhibitor. There is a triplet combination looking in Phase 1 setting with a next generation FGFR inhibitor with EV-pembro. However, it's not a randomized trial. So you know, I worry about such kinds of combinations where we don't have a path for registration. And in the four patients that have been treated, four or five patients in the early phase as a part of basket trial, the toxicities were a lot, you know, when you combine the EV-pembro and an FGFR3 inhibitor, we see more and more toxicity. So the big question is do we really need the "kitchen sink" approach when we have a very good doublet, or unless the bar is so high with the doublet, like what are we trying to add at the expense of patient toxicity and quality of life is the big question in my mind. Dr. Rafeh Naqash: Going back to your manuscript specifically, there could be a composite biomarker. You point out like FGFR in addition to FGFR TMB ends up being predictive prognostic there. So that could potentially be used as an approach to stratify patients as far as treatment, whether it's a single agent versus combination. Maybe the TMB-low/FGFR3 mutated require a combination, but the TMB-high/FGFR mutated don't require a combination, right? Dr. Shilpa Gupta: No, that's a great point, yeah. Dr. Rafeh Naqash: But again, very interesting, intriguing concepts that you've alluded to and described in this manuscript. Now, a quick take on how things have changed in the bladder cancer space in the last two years. We did a podcast with you regarding some biomarkers as you mentioned two years back. So I really would like to spend the next minute to two to understand how have things changed in the bladder cancer space? What are some of the exciting things that were not there two years back that are in practice now? And how do you anticipate the next two years to be like? Maybe we'll have another podcast with you in another two years when the space will have changed even more. Dr. Shilpa Gupta: Certainly a lot has happened in the two years, you know. EV-pembro became the universal frontline standard, right? We have really moved away from cisplatin eligibility in metastatic setting because anybody would benefit from EV-pembro regardless of whether they are candidates for cisplatin or not, which historically was relevant. And just two days ago, we saw that EV-pembro has now been approved for localized bladder cancer for patients who are cisplatin ineligible or refusing. So, you know, this very effective regimen moving into earlier setting, we now have to really think of good treatment options in the metastatic setting, right? So I think that's where a lot of these novel combinations may come up. And what else we've seen is in a tumor agnostic trial called the DESTINY-PanTumor trial, patients who had HER2 3+ on immunohistochemistry, we saw the drug approval for T-DXd, and I think that has kind of reinvigorated the interest in HER2 in bladder cancer, because in the past targeting HER2 really didn't work. And we still don't know if HER2 is a driver or not. And at ESMO this year, we saw an excellent study coming out of China with DV which is targeting HER2, and toripalimab, which is a Chinese checkpoint inhibitor, showing pretty much similar results to what we saw with EV-pembro. Now, you know, not to do cross-trial comparisons, but that was really an amazing, amazing study. It was in the presidential session. And I think the big question is: does that really tell us that HER2-low patients will not benefit? Because that included 1+, 2+, 3+. So that part we really don't know, and I think we want to study from the EV-302 how the HER2 positive patients did with EV and pembro. So that's an additional option, at least in China, and hopefully if it gets approved here, there is a trial going on with DV and pembro. And lastly, we've seen a very promising biomarker, like ctDNA, for the first time in bladder cancer in the adjuvant setting guiding treatment with adjuvant atezolizumab. So patients who were ctDNA positive derived overall survival and recurrence-free survival benefit. So that could help us select moving forward with more studies. We can spare unnecessary checkpoint inhibitors in patients who are not going to benefit. So I think there is a lot happening in our field, and this will help do more studies because we already have the next generation FGFR inhibitors which don't have the toxicities that erdafitinib comes with. And combining those with these novel ADCs and checkpoint inhibitors, you know, using maybe TMB as a biomarker, because we really need to move away from PD-L1 in bladder cancer. It's shown no utility whatsoever, but TMB has. Dr. Rafeh Naqash: Well, thank you so much, Shilpa, for that tour de force of how things have changed in bladder cancer. There used to be a time when lung and melanoma used to lead this space in terms of the number of approvals, the biomarker development. It looks like bladder cancer is shifting the trend at this stage. So definitely exciting to see all the new changes that are coming up. I'd like to spend another minute and a half on your career. You've obviously been a leader and example for many people in the GU space and beyond. Could you, for the sake of our early career especially, the trainees and other listeners, describe how you focused on things that you're currently leading as a leader, and how you shaped your career trajectory over the last 10 years? Dr. Shilpa Gupta: That's a really important question, Rafeh, and you and I have had these discussions before, you know, being an IMG on visas like you, and being in different places. I think I try to make the most of it, you know, instead of focusing on the setbacks or the negative things. Like tried to grab the opportunities that came along. When I was at Moffitt, got to get involved with the Phase 1 trial of pembrolizumab in different tumor types. And just keeping my options open, you know, getting into the bladder cancer at that time when I wanted to really do only prostate, but it was a good idea for me to keep my options open and got all these opportunities that I made use of. I think an important thing is to, like you said, you know, have a focus. So I am trying to focus more on biomarkers that, you know, we know that 70% patients will respond to EV-pembro, right? But what about the remaining 30%? Like, so I'm really trying to understand what determines hyperprogressors with such effective regimens who we really struggle with in the clinic. They really don't do well with anything we give them after that. So we are doing some work with that and also trying to focus on PROs and kind of patient-reported outcomes. And a special interest that I've now developed and working on it is young-onset bladder cancer. You know, the colorectal cancer world has made a lot of progress and we are really far behind. And bladder cancer has historically been a disease of the elderly, which is not the case anymore. We are seeing patients in their 30s and 40s. So we launched this young-onset bladder cancer initiative at a Bladder Cancer Advocacy Network meeting and now looking at more deep dive and creating a working group around that. But yeah, you know, I would say that my philosophy has been to just take the best out of the situation I'm in, no matter where I am. And it has just helped shape my career where I am, despite everything. Dr. Rafeh Naqash: Well, thank you again. It is always a pleasure to learn from your experiences and things that you have helped lead. Appreciate all your insights, and thank you for publishing with JCO PO. Hopefully we will see more of your biomarker work being published and perhaps bring you for another podcast in a couple of years. Dr. Shilpa Gupta: Yeah, thank you, Rafeh, for the opportunity. And thanks to JCO PO for making these podcasts for our readers. So thanks a lot. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. DISCLOSURES Dr. Shilpa Gupta Stock and Other Ownership Interests: Company: BioNTech SE,  Nektar Consulting or Advisory Role: Company: Gilead Sciences, Pfizer, Merck, Foundation Medicine, Bristol-Myers Squibb/Medarex, Natera, Astellas Pharma, AstraZeneca, Novartis, Johnson & Johnson/Janssen Research Funding: Recipient: Your Institution Company: Bristol Myers Squibb Foundation, Merck, Roche/Genentech, EMD Serono, Exelixis, Novartis, Tyra Biosciences, Pfizer, Convergent Therapeutics, Acrivon Therapeutics, Flare Therapeutics, Amgen Travel, Accommodations, Expenses: Company: Pfizer, Astellas Pharma, Merck    

    Insane Erik Lane's Stupid World
    Sniifing Farts, DoorDash-dardly Deed, Dead Hog Smorgasboard

    Insane Erik Lane's Stupid World

    Play Episode Listen Later Dec 17, 2025 88:27 Transcription Available


    (00:00:00) Sniifing Farts, DoorDash-dardly Deed, Dead Hog Smorgasboard (00:00:43) Midweek BONUS Stupidity (01:01:26) Insane Week In Review (01:09:46) Genius Awards Increase your brain power ...not from Reader's Digest, but from your own "air biscuits"! If you're getting food from a DoorDasher, better have your Ring Camera rolling! Internet influencers have really gone to the hogs...as in eating them raw, on college campuses.In this Midweek BONUS Episode...A Guy Robbed a Liquor Store with an "Old-Timey" GunGA Man Shoots at Random Shopper Outside of Lowe's–Wanted to Be RewardedA Guy Uses a Snow Blower To Assault Someone With SnowIn-N-Out Removed "67" From Its Order NumbersFL Woman Arrested After Being Seen Walking On A Sidewalk Sipping Cinnamon Whiskey—Wearing NOTHING Below The WaistNJ Man Who Portrayed Santa Claus Charged with Child Porn OffensesFL Woman Faces Felony for Throwing Chicken at Victim's FaceDoorDash Driver Accused of Spraying Pepper Spray on Arby's Food After Dropping It Off At a Home...Over a Small TipWhich English-Speaking Countries Use the F-Word the Most? "F'ing USA"FL Car Thief Said He Was "Teleported” Into Stolen BMWDeer Attack Blow-up Reindeer Decor on Woman's Front LawnViral TikTok Holiday Treat: Vanilla Ice Cream...Doused in Red Wine(SICKO) FL Man Cut Open, Ate Dead HOG at Clock TowerNJ man praised for trying to save neighbor in fire is now charged in her murderFormer DoorDash Driver Pleads Not Guilty To Filming Unconscious, Half-Naked CustomerThis Is Why You Don't Blow Leaves on Your Rooftop When You're 86A Guy Called the Cops After the Car He Stole Got TowedA Lawyer Is Suing the IRS, Demanding Pets Count as Legal DependentsSniffing Your Own “Air Biscuits” Boosts Brain PowerFL Woman Charged Again For Public Sex Activity In Parking LotPornhub reveals number of women watching X-rated videos is surgingAnd our weekly stupid rundown from the latest current events in the Insane Week in Review plus the 7 "winner" from this week's Genius Awards!Become a supporter of this podcast: https://www.spreaker.com/podcast/insane-erik-lane-s-stupid-world--6486112/support.Real-time updates and story links are found on the TELEGRAM Channel at: https://t.me/InsaneErikLane  (Theme song courtesy of Randy Stonehill, ”It's A Great Big Stupid World”. Copyright ©1992 Stonehillian Music/Word Music/Twitchin' Vibes Music/ASCAP) Order your copy on the Wonderama CD from Amazon!This episode includes AI-generated content.

    WRHI » Palmetto Mornings
    12/17/2025: Lt. Michael Chavis (Rock Hill Police Department), Wanted Wednesday

    WRHI » Palmetto Mornings

    Play Episode Listen Later Dec 17, 2025 9:42


    KRLD All Local
    A shocking crime out of Lavon, a 14 year old is wanted for murder

    KRLD All Local

    Play Episode Listen Later Dec 16, 2025 17:07


    Plus the Cowboys blow a great chance and Arlington rolls out the red carpet

    Outlook
    Tulisa: I wanted fame, but it almost destroyed me

    Outlook

    Play Episode Listen Later Dec 15, 2025 39:10


    N-Dubz singer Tulisa Contostavlos survived betrayal and a tabloid sting.Tulisa was born into a family of musicians in Camden, London, and says music was part of her everyday life. But her childhood was impacted by her mother's severe mental health episodes that would often end up with her being held in psychiatric institutions. After her parents divorced, Tulisa would frequently have to care for her mother by herself. Tulisa escaped into music, and although she was initially determined to become a solo star, she found huge success with the UK group N-Dubz, formed with a cousin and a friend, when she was in her teens. At the age of 22 she became the youngest ever judge on the UK TV talent show The X Factor, but her biggest challenge was working out how to survive in the spotlight. At the peak of her fame an ex-boyfriend released an intimate video of her online, without her consent, and Tulisa had to go to court to have it removed from websites. In 2013 she was also the target of an elaborate undercover newspaper sting that led to her facing jail for drug supply, before the trial collapsed and she was cleared. The experience almost derailed her career, and her life. Tulisa's latest book is called Judgement.Presenter: Mobeen Azhar Producers: Tommy Dixon and Rebecca VincentThis interview contains reference to suicide. If you are suffering distress or despair and need support, you could speak to a health professional, or an organisation that offers support. Details of help available in many countries can be found at Befrienders Worldwide. www.befrienders.orgLives Less Ordinary is a podcast from the BBC World Service that brings you the most incredible true stories from around the world. Each episode a guest shares their most dramatic, moving, personal story. Listen for unbelievable twists, mysteries uncovered, and inspiring journeys - spanning the entire human experience. Step into someone else's life and expect the unexpected.   Got a story to tell? Send an email to liveslessordinary@bbc.co.uk or message us via WhatsApp: 0044 330 678 2784   You can read our privacy notice here: https://www.bbc.co.uk/programmes/articles/5YD3hBqmw26B8WMHt6GkQxG/lives-less-ordinary-privacy-notice

    Dukes & Bell
    Kirk Cousins should leave even if Falcons wanted him back

    Dukes & Bell

    Play Episode Listen Later Dec 15, 2025 10:09


    Mike and Beau get into some more football talk and share some thoughts on the Falcons and Kirk Cousins relationship and where it stands in regards to the veteran QB returning to the team next season, to which Beau believes Cousins should leave and give himself a fresh start elsewhere.

    The Family Herbalism Podcast
    45. 8 Things You Wanted to Learn About Me

    The Family Herbalism Podcast

    Play Episode Listen Later Dec 15, 2025 60:51


    ​Where did the name Laurel Tree Wellness come from? ​ What are your life Bible verses?How do you keep “first things first”?Have you shared your salvation story?Have you ever wished you engaged differently with the guests on your show?What were the hardest, best, and most rewarding parts of doing the podcast?Where do you see yourself in 5 and 10 years?If you could only have three herbs available, which ones would they be?Join me in this final weekly episode where I answer your questions and share how you can continue to engage in herbal education!If you have just arrived here at The Family Herbalism Podcast, welcome!

    Doctor DC Podcast
    The Epstein Files (w/ You Wanted Ms.)

    Doctor DC Podcast

    Play Episode Listen Later Dec 14, 2025 75:04


    Conspiracy theories abound as we dodge having to talk facts in favour of fictions when it comes to the Jeffrey Epstein files.Follow us on Instagram!Submit your topics and vote on others on our subreddit!Get even more content from us on Patreon!Proudly part of The Sonar Network! Hosted on Acast. See acast.com/privacy for more information.

    Grace Free Church Talks
    You Wanted Clarity, But You Got Confusion (The Gift You Didn't Ask For)

    Grace Free Church Talks

    Play Episode Listen Later Dec 14, 2025 30:00


    Life rarely hands out clear directions—especially around the holidays. When you want clarity but all you have is confusion, it can feel unsettling: detours you didn't plan for, decisions you're afraid to get wrong, and “why is this happening now?” moments that mess with your peace. Mary and Joseph didn't receive a detailed plan—they were given an inconvenient push, and God still used it to move them exactly where they needed to be. The reminder is simple: you may feel lost, but you're not abandoned. God can direct even when you don't understand it, and the “Caesars” in your life don't get the final say. Faith doesn't avoid the mess — it finds Jesus in it. Your faith was made for the mess. (Talk by Joshua Ott)

    LSAT Unplugged
    If I Wanted to Get Into Harvard Law in 2026, Here's Exactly What I'd Do (FULL BLUEPRINT)

    LSAT Unplugged

    Play Episode Listen Later Dec 14, 2025 27:01


    Joshua Ott's Podcast
    You Wanted Clarity, But You Got Confusion (The Gift You Didn't Ask For)

    Joshua Ott's Podcast

    Play Episode Listen Later Dec 14, 2025 0:01


    Life rarely hands out clear directions—especially around the holidays. When you want clarity but all you have is confusion, it can feel unsettling: detours you didn't plan for, decisions you're afraid to get wrong, and “why is this happening now?” moments that mess with your peace. Mary and Joseph didn't receive a detailed plan—they were given an inconvenient push, and God still used it to move them exactly where they needed to be. The reminder is simple: you may feel lost, but you're not abandoned. God can direct even when you don't understand it, and the “Caesars” in your life don't get the final say. Faith doesn't avoid the mess — it finds Jesus in it. Your faith was made for the mess.

    Real Ghost Stories Online
    Something in the Basement Wanted Him Alone | Real Ghost Stories CLASSIC

    Real Ghost Stories Online

    Play Episode Listen Later Dec 13, 2025 33:05


    A young couple in Denver thought they were simply buying their first home — a modest 1950s ranch with a big yard, a friendly layout, and a long history belonging to only one elderly family. But the moment they began remodeling the basement, the house revealed what the previous owners had quietly left behind. Buried deep in the foundation, they found a polished wooden stick wrapped in green and yellow tassels — an Irish chalet hidden exactly where no one should have ever reached it. And once it was disturbed, nothing in the house felt normal again. Her husband became fixated on the basement, refusing to come upstairs. His personality shifted. His dreams turned violent. And when they uncovered old glass jars sealed into the ceiling — jars filled with nails, hair, and strange liquids — the pieces began forming a shape she didn't want to recognize. Was this Irish folklore? Witchcraft? A curse? Or something darker using the objects these strangers left behind? #realghoststories #hauntedhouse #witchjars #paranormalactivity #irishfolklore #demonicattachment #hauntedbasement #trueghoststory #creepyhome #darkpresence #unexplained #supernaturalstory #witchcrafthistory #ghostpodcast #realhauntings Love real ghost stories? Don't just listen—join us on YouTube and be part of the largest community of real paranormal encounters anywhere. Subscribe now and never miss a chilling new story:

    D-Lo & KC
    "I Won't Say What I Wanted To Say"

    D-Lo & KC

    Play Episode Listen Later Dec 12, 2025 180:32


    The Rich Keefe Show
    JD Martinez was the last big fish the Red Sox actually wanted and got

    The Rich Keefe Show

    Play Episode Listen Later Dec 12, 2025 8:24


    Sure the Red Sox signed Alex Bregman last offseason, but that came along very quickly. The last big fish the Sox wanted early on and made a push for was JD Martinez before the 2018 season and we haven't seen anything like it since.

    The Dr. Greenthumb Podcast
    Gene Simmons Testifies Before Senate, Old Lady Wanted by FBI, +More | The Dr. Greenthumb Show

    The Dr. Greenthumb Podcast

    Play Episode Listen Later Dec 11, 2025 112:53


    Joe Benigno and Evan Roberts
    Edwin Diaz Wanted to Be Informed about Devin Williams

    Joe Benigno and Evan Roberts

    Play Episode Listen Later Dec 10, 2025 8:54


    Edwin Diaz was reportedly unhappy with the Mets for a nonsensical reason