Podcasts about CRS

Blood Cancer Talks — Show NotesEpisode: Best of ASCO/EHA 2026 — Multiple Myeloma & AL AmyloidosisGuest: Dr. Prashant Kapoor, MD Professor of Medicine, Mayo Clinic, Rochester, MN Chair, Myeloma, Amyloidosis and Dysproteinemia Group, Mayo ClinicEpisode OverviewIn this episode, the hosts sit down with Dr. Prashant Kapoor to review the highest-impact multiple myeloma and AL amyloidosis data from the 2026 ASCO and EHA annual meetings. The discussion centers on the rapidly shifting relapsed/refractory myeloma landscape, where a wave of phase 3 trials of T-cell engaging immunotherapies (bispecific antibodies and CAR T) have now each demonstrated superiority over traditional triplet regimens. Topics Covered1. MajesTEC-3Phase 3, open-label trial of teclistamab + daratumumab SC (n=291) vs. investigator's choice of DPd or DVd (n=296) in 587 patients with relapsed/refractory myeloma and 1–3 prior lines; prior BCMA-directed therapy and anti-CD38-refractory disease were exclusions (only 5% CD38-exposed, none were refractory). Initially presented at ASH 2025, with cytogenetic subgroup data updated at EHA 2026.Key results (34.5-month median follow-up):Median PFS not reached with Tec-Dara vs. 18.1 months with DPd/DVd; 36-month PFS 83.4% vs. 29.7% (HR 0.17)36-month OS 83.3% vs. 65.0% (HR 0.46)Severe infection rate front-loaded: ~35% → ~17% between the first and second 6-month windows, plateauing at ~10–11%/window beyond 12 months; overall grade 3–4 infection 54%, 4.6% fatal infections (mostly without IVIG prophylaxis)EHA 2026 cytogenetic subgroup: 2-year PFS 90% (0 HRCA), 82% (1 HRCA), 76% (≥2 HRCA) — vs. only 14% with DPd/DVd in patients with ≥2 HRCADiscussion points: Applicability to patients at 1st/2nd relapse seen in clinic today; whether infection risk limits use of Tec-Dara at first relapse; implications of the high-risk cytogenetic subgroup data.2. MajesTEC-9Phase 3 trial of teclistamab monotherapy vs. investigator's choice of PVd or Kd in relapsed/refractory myeloma enrolling a heavily anti-CD38-refractory population (100% CD38-exposed, 85% refractory) — the population MajesTEC-3 excluded. Natural comparator: CARTITUDE-4 (phase 3, cilta-cel vs. DPd/PVd in Len-refractory myeloma, 1–3 prior lines, ~25% CD38-refractory/exposed).Key results (~18-month median follow-up):18-month PFS 70% vs. 27% (HR 0.29); 18-month OS 79% vs. 69% (HR 0.6), despite ~2/3 of control-arm patients receiving BsAb/CAR T as subsequent therapyDiscussion points: Cross-trial comparison with CARTITUDE-4 — comparable 18-month PFS on cross-trial comparison, but differing populations (CARTITUDE-4 required Len-refractory disease; MajesTEC-9 enrolled a more CD38-refractory population) and differing maturity (~3-year vs. ~1.5-year follow-up); how Dr. Kapoor chooses between teclistamab and cilta-cel at earlier-line relapse in Len- and CD38-refractory patients, given the divergent toxicity profiles — ongoing infection risk with continuous BsAb dosing vs. the one-time cilta-cel infusion with its rare but potentially irreversible delayed neurotoxicity, IEC-enterocolitis, and CTTLN risk.3. MonumenTAL-3Phase 3 trial — the first phase 3 study of a GPRC5D-targeted bispecific — randomizing 864 patients with relapsed/refractory myeloma (mostly Len-refractory, ~10% CD38-exposed but none refractory) 1:1:1 to Tal-Dara-Pom (n=287), Tal-Dara (n=287), or DPd (n=290), each Talq arm compared against the common DPd control. Presented by Peter Voorhees at EHA 2026 and simultaneously published in NEJM.Key results (24.6-month median follow-up):Both Talq arms significantly improved PFS over DPd: Tal-DP HR 0.28, Tal-D HR 0.33 (both P

Welcome to Hot Topics! In this episode, host Gabrielle Crichlow sits down with guest Carly Alyssa Thorne to discuss congenital rubella syndrome, a condition that results from a mother contracting rubella during pregnancy. Carly shares her personal experience living with the chronic illness, including the symptoms she faces and how it has impacted her life. Join us for an enlightening conversation that sheds light on the challenges and resilience associated with this important health topic.Who is Carly Alyssa Thorne?Carly Alyssa Thorne is a Director, Producer, Actress, Author, and Speaker with over 30 years in the conscious transformation field. Blending Eastern and Western philosophies, she integrates wellness, spirituality, and storytelling to create media and experiences that inspire growth and healing. A former fitness and wellness center owner and certified Life Coach, Reiki Master, NLP and Hypnotherapy Practitioner, and Interfaith Ordained Minister, Carly brings a holistic lens to every production and collaboration. Her work bridges film, business, and consciousness—empowering others to embody their truth, elevate their message, and lead with purpose.You can find Carly:On the web: https://carlyathorne.com/On Facebook: https://www.facebook.com/carlyalyssathorneOn Instagram: https://www.instagram.com/carlyathorne On Threads: https://www.threads.com/@carlyathorneOn X: https://twitter.com/carlyathorneOn LinkedIn: https://www.linkedin.com/in/carlyalyssathorne/On YouTube: https://www.youtube.com/c/CarlyAlyssaThorne-TheTransformerOn Pinterest: https://www.pinterest.com/carlyathorne/Freebie: Tell Carly that you heard about her from our podcast "Hot Topics!" and she'll give you a free 30-minute discovery call for coaching! Her email is carlyathorne@gmail.com.Watch this episode on YouTube: https://youtube.com/live/ckSk1sZ7KTMOriginal Date of Episode: July 23, 2026Become a supporter of this podcast: https://www.spreaker.com/podcast/hot-topics--5600971/support.

The Suite Spot attended the 2026 Hotel Data Conference and had the opportunity to interview some of the best and brightest hospitality leaders in the industry to gain their insights and perspectives on prevailing data trends, AI & technology, how to optimize the guest experience and much more.  Be sure to watch the full episode if you missed any of the action from the 2026 Hotel Data Conference.  Special thanks to: Amanda Hite, Jan Freitag, Erica Lipscomb, Max Spangler, & Sam Trotter. Ryan Embree: Welcome to Suite Spot, where hoteliers check in and we check out what’s trending in hotel marketing. I’m your host, Ryan Embree. Hello, everyone. Ryan Embree here at the 2026 Hotel Data Conference here with STR President Amanda Hite. Amanda, great to see you again. Congratulations here. This is our first time at the Hotel Data Conference. Amanda Hite: Oh, wonderful. Thank you. Ryan Embree: Record attendance was just announced. Welcome to The Suite Spot. We’re excited to be here. It was a ton of excitement that we just saw. Tell us a little bit about this event, and we were talking off camera about, do you ever expect it to be what it is right now? Amanda Hite: Yes, we started it 18 years ago with a couple hundred people, maybe. The very first year we’ve always had it in Nashville. This is our home base for the STR part of our business. Most of our employees are here that are in the US. So we started it with a way to connect with customers and more importantly, like, we all have this curiosity about the data. You know, we’re constantly in analyzing, looking at trends in the industry, and we wanted to get people together to hear what are you seeing and let’s talk about it. And that’s really how this started. So it’s, I think it’s for me, my most proud part of this conference is the feeling that everyone has when they come in of being really open and curious and wanting to learn from each other. So you get some really good dynamic conversations happening in the networking breaks and in the hallway. Ryan Embree: Well, it’s such an important time right now too, right? ‘Cause people are already starting, if you can believe it. Well, actually, probably you can look in 2027. Amanda Hite: That’s why we do hotel data conference when we do it. Exactly. It’s budget season. Ryan Embree: Brilliant. Brilliant. Right? And, you know, you just got off stage, like I said. One of the fascinating pieces, like I said, we weren’t here last year, but this is our first time. You said when you first stepped on stage, there were, and you showed some of those original numbers. There was a little bit of a gap in the audience last year. Amanda Hite: Yes. Ryan Embree: But this year, a little bit different story. Amanda Hite: Yes. We had a much better forecast to reveal this year. Last year at this time was when we took the forecast down to reflect what was happening in the industry. And this year, we raised the forecast, not just for the rest of this year, but also for 2027. Ryan Embree: So great to see. And a really cool inflection point, I made a note here, revenue for the first time outpacing expenses, right? What does that mean for hoteliers? Amanda Hite: Yeah. So we finally see the pace of growth on the revenue side outpacing the expense growth. I mean, we’re in a high inflationary environment. Expense growth is something that will continue and hoteliers are having to deal with. But to see that we’re actually going to get some GOP gains, it’s, it’s super helpful. I mean, the point I made this morning though is our margins are not growing. Yeah. So we’ve got some room to grow efficiencies and productivity within the hotels to try to get margins to grow at the same rate of GOP growth. Ryan Embree: Yeah, yeah. It’s challenging right now. And one of the things we’re doing to combat, or CoStar’s doing combat that, bottom line data being added to the product. What’s that mean for the hotel industry? Ryan Embree: Yeah, so within STR Benchmark and the CoStar platform, we introduced at the end of the first quarter our profitability benchmarking. P&L is something that STR has done for 30 years. We did it on an annual basis. And we introduced our monthly benchmarking back in 2020, literally as the world shut down. So maybe not the best timing. But of course, now we’re prepared in an environment like we are today, a very complex operating environment for our hoteliers. It’s, yes, we need to grow revenues, but we must make sure that that is flowing through to the bottom line and that our operators and owners are actually making money. And that’s not been the case in many types of hotels and many markets around the country. So we’re trying to make sure that we bring that visibility of not just the top line growth that we want to see for the industry, but the flow through all the way to the bottom line. Ryan Embree: Yeah, I’d love to see that. And, you know, another thing that we’re gonna hear constantly about at, and at this conference is AI, right? So I guess the overarching question would be more of like, how are you incorporating AI into your products right now? Amanda Hite: This is when I’m so thankful that we are a part of the CoStar Group entity. If you follow our other brands, homes and apartments launched AI in their products earlier this year. So we’re continuing to build off of that. We will have AI search in the CoStar product in the same way that you see in apartments and homes. But for STR benchmarks specifically, what we’re thinking about is making sure that we’re integrating AI into the product, not just sitting on top of the product, but like we interact with the clients all the time on the analysis in the industry. So we want to bring that through AI into the product for our customers to use. So we love when they pick up the phone and call us and wanna talk about data. Right. But we also wanna make it easier for them to surface it within their portfolios in product. And so that’s the path that we’re going down to bring that intelligence in the product and analyzing and spotting the trends, knowing what to look at or sometimes not look at, right? Sometimes it’s a great point. It’s just as important to say like, “Hey, I only have a limited amount of time. Where do I not need to spend time right now?” And that can be tricky, especially when you’re looking at a larger portfolio of trying to discern where, what makes the most sense to drive profitability for my business, for me to spend time on right now. Ryan Embree: 100%. Those complexities and driving efficiency so important right now. And turning those data, that data into actual insights. That what one of the promises of AI. So reason we’re here at the Hotel Data Conference, thank you for taking the time. We’ll, we’ll let you get back. I know you’re hosting almost 900 hoteliers here. So we’ll let, let you get back to Amanda. Thanks for stopping by. Amanda Hite: Thank you, Ryan. Appreciate it. Ryan Embree: Hello, everyone. Ryan Embree here with The Suite Spot live on location Nashville at the 2026 Hotel Data Conference here with Jan Freitag, National Director at CoStar. Jan, thank you so much for taking some time and very busy. You’re hosting almost a thousand hoteliers here. Jan Freitag: Yes, 18th year. Sold out again. So heads up, next year we’ll sell out again. But thanks for being here and sort of taking the pulse on the industry. We appreciate it. Ryan Embree: 100%. Congratulations. Amanda Hite opened us this morning saying last year when she unveiled the forecast, there were audible gaps in the crowd. I feel like behind us, people have been skipping, jumping down, up and down this escalators. Share with us, we got a revised forecast. Jan Freitag: So we’re proposing that RevPar this year is up 4.4%. So that is the second upward revision we had to make, quote unquote. And the data’s just so strong. But then that means that next year, we’re gonna see growth, but it’s much slower global. So next year we’re thinking that RevPargrowth is gonna be like, you know, 2-2.1% or so. So the negative way to say this is, “Oh, our growth rate is cut in half.” The positive way to say this is like, “Oh, we have growth on growth, right? 4% this year, ne – 2% next year.” Ryan Embree: 100%. I mean, a lot of people are going into, you know, we’ve talked to hoteliers here on the Suite Spot, going into their budgets. These are very, very important numbers for them as they go into their budgets because they wanna forecast. When we met last, we were at NYU. There had been zero soccer games played in the US. Now, 104 games later, we got a crown champion. Obviously had a big impact. We’re gonna talk about that in a minute. But that strong performance, one of your big takeaways from this morning was strong performance is gonna equal some tougher comps in 2027, right? Jan Freitag: Yeah, absolutely. So we had arguably easy comps this year, right? The Q2, three, and four RevPAR performance last year was negative. So yeah, we would outperform it this year. That was not a question. But because, RevPAR in the second quarter was up 5.7%, that is a, a very stout result, obviously driven in June, partially by the World Cup remember we’re gonna talk about. You know what that means for next year is, oh wow, we’re not gonna see that performance again. And so my conversation this morning with hoteliers is all about, okay, so how do you massage your owner? How do you have this conversation with your owner, with your team to say, look, there’s still gonna be growth, but we really have to think about this. And I heard this this morning from an asset manager at next year as a year of 10 months and two months, you know? So really take June and July out of your annual number and say, okay, so what’s the growth for that? And then, yeah, June, July is just gonna be tough cost. Ryan Embree: Yeah. Probably something that a lot of markets who hosted Taylor Swift a couple years ago had to deal with. And then maybe what LA’s gonna have to deal with in 2029 after the Olympics in 28. Jan Freitag: Yeah, exactly. So we’re already talking now about the Olympics. We’re gonna talk about, obviously the World Cup in four years over in Europe and what is the performance there. So these sporting events are just the gifts that keep on giving. Ryan Embree: Yeah. Yeah. And, and travelers continue what we heard this morning. Consumers continue to prioritize travel, which is really, really great for obviously our industry. But not without its cautionary tales, you also had a watch your margins kind of take away from that. Maybe expand on that a little bit. Jan Freitag: Yeah. So we’ve had for the last year and for the last couple of years, really this interplay between room rate growth and the rate of inflation being higher than room rate growth. And we’re taking the rate of inflation sort of as a proxy for how much more things are expensive. And the costs for hotels are obviously going up. Higher labor costs, higher insurance costs, higher food costs, higher costs, inner energy, everything. So if your costs are going up in order for your margins to expand, you need to drive room rate or revenue faster than the cost increase. And that just is not happening. So my colleague Isaac Collazo spent 55 slides and an hour explaining how margins are decelerating, unfortunately. Now, the total dollar amount, we’re everything gets more expensive, but it also means we’re having more money available as profit. But the margins are coming down. And that’s really the, maybe to me, the main takeaway from HCC this year for the budget conversation for 2027 is watch your margin. Ryan Embree: Efficiency is always looking for that, especially in these tight margin areas. And then lastly, you know, your whole presentation this morning was themed around the World Cup. And, and I do wanna bring it up because, obviously there was the quote was 104 Super Bowls. Yeah. Right? And you kind of explored that case a little bit. Found out maybe that might not be the case. Jan Freitag: Yeah, exactly. So the FIFA president had said at the time, just to explain to American audiences, “Hey, we have 104 soccer games and they look like 104 Super Bowls.” That is of course not the case. And that was never meant to be the case. Super Bowl is the largest cultural sport event in America. It happens once a year, right? And to sort of translate that was, I thought always a little silly. So it turns out that the 104 Super Bowls did not come to pass, and it was more like 30 Super Bowls, maybe if that. So yeah, it was still a very healthy impact. If you look at the markets that Hosta gave Kansas City, New York, Philadelphia, Boston, very, very strong room rate growth. Interestingly, in some markets, actually, occupancy declines. We saw that specifically in Vancouver, but we saw it in Atlanta, we saw it in Boston. Why is that? Well, because corporate America, meeting travelers, meeting planners said, “You know what? I don’t need to compete with the Tartan Army in Boston for our meeting. You know, let me just stay away. Let me have that meeting in August, or let me move that meeting to Chicago,” for example. Sure. Chicago had a very, very strong June, July meeting calendar. So it’s, um, the, the room rate increase was absolutely expected and is exactly what came to pass. It just wasn’t Autumn for a Super Bowl. Ryan Embree: Yeah. I mean, that just proves we are, uh, a collective of markets. Things are gonna be obviously different in each one. Yeah. Uh, with different factors there. You know, a- and there’s also an interesting stat, fascinating stat, I wanna bring it up, about booking windows, um, that, that you brought up there. Yeah. If you wanna expand on that. Jan Freitag: So I got this totally wrong in the run up to the World Cup because I thought, look, if somebody books that FIFA ticket a year out, and the airplane ticket’s six months out, surely they would book their hotel three months out. Yeah. That did not happen. Right. And so we saw specifically the chart that I had this morning for, uh, arrival dates, June 11, 12, 13, 20 basis points of, uh, 20 points of occupancy was booked after June 8th. Wow. So that’s a booking windows of, like, three or four days. Wow. For an event that you knew what happened, I mean, six years ago. Yeah. You know? And you had a ticket from one year ago. So I just completely though that the, uh, the, the leisure traveler, the, the soccer traveler would also book their room way ahead. That did not come with us. Ryan Embree: Very interesting. I wonder if that’s a macro trend happening right now, those booking windows starting to shorten a little bit. Jan Freitag: Yeah, and maybe that’s a takeaway for our friends, you know, in LA who are hosting the Olympics. Hey, you know, be very mindful how you match that booking window. Ryan Embree: Lessons from history learned there. Yes. Um, final as we wrap up, I always li- like, like to get any, you know, you look at a lot of data. So any interesting, uh, like, data points that really stood out or surprising? Jan Freitag: I mean, the July data came out yesterday and the luxury class RevPar growth was 16%. Ryan Embree: Wow. Jan Freitag: Talk about A, amazing, but B, A, tough comps. Yeah. In July of next year. But it was an amazing, amazing performance. July was very, very strong. Um, and June as well. So we clearly saw, you know, July was helped a little bit by 4th of July, World Cup, uh, 4th of July calendar year, but also the World Cup, obviously the final and the bronze medal games. They all, they all helped. So July was strong, June was strong. So now I think things are getting a little bit more normal – Yeah. Early on end. Ryan Embree: Awesome. Well, we’ll continue to look ahead as you will, but thank you again for taking time out of your busy schedule, Jan. Jan Freitag: Thanks for being here. Thank you. Ryan Embree: Hello everyone, Ryan Embree here with The Suite Spot. We are live on location of the 2026 Hotel Data Conference. I am here with Erica Lipscomb, EVP of Commercial Strategy at PM Hotel Group. Erica, thank you so much for joining me on The Suite Spot. Erica Lipscomb: Well, thank you for having me. Very excited to be here. Ryan Embree: Yeah, first time here on the Suite Spot. Yes. But not your first time here at Hotel Data Conference. Erica Lipscomb: Not my first time at Hotel Data Conference. This is conference number eight. Ryan Embree: Okay. Yes. All right. Hotel data conference. You obviously are no stranger, you’re a pro. What do you call a hotel data conference a success kind of reflecting back? What do you come here to accomplish and to learn? Erica Lipscomb: You know, I, again, this is our start of budget season. Sure. Right? Yeah. So I actually, uh, had dinner with Amanda last night and said, “You do realize what you’ve done here, right? We cannot even start our budget calendars until there’s an HTC.” Yeah. So really what I look forward to is not coming here just to hear that the amazing news of an increase year over year, or that we’re gonna increase in the year for the year. Sure. But what are those things that I can take away that can make it tactical for our teams? Mm-hmm. So learning from industry leaders that are here. We have amazingly smart people that are here at this conference. And we’re really drafting and shaping what the industry will look like. So what are those learnings? And then how do I make sure that we trickle that down within the organization and get them to our teams? Ryan Embree: Which can change so rapidly, right? As we know – Absolutely. It’s gone from, uh, a yearly change to almost, it feels like a weekly, especially with the AI and technology conversation. Yes. You were on a panel last year here at this same conference. I’m curious, what were some of the conversations then versus now? Erica Lipscomb: Yeah. And very different. I think it’s been extreme polar opposites. Okay. I feel like last year, there was a lot of conversation about AI. Mm-hmm. But more on the what is AI. Mm. And how are we gonna use AI? Yep. And it’s already started in conversations this morning. You know, we started networking last night, and most people are now really talking about what is AI doing for us to make sure that we’re efficient, making sure that our teams are effective, um, ensuring there’s profitability back to our owners. So it’s gone from a concept – Yeah. To now actually, how are we utilizing AI to be better in the industry, but keeping the forefront our customers? Ryan Embree: It feels like we’re in the sandbox now, right? And there’s a lot of companies out there trying different things. It’s the exploration process and, you know, maybe some success, but even, uh, lessons in the failure. Uh, I, I’ve been hearing a lot about that as well. So hotel data, obviously data is the name of the game. Yes. Still one of the most important tools I feel like right now on our quest of guest personalization. And so much it can do to kind of like what you said, prepare us for the rest of 2026 and even into 2027. Right. How is PM Hotel Group kind of leveraging data for growth and, uh, experiences? Erica Lipscomb: So actually you started with, with growth and experiences. Yeah. So really starting with growth. Yeah. We really are starting with AI in our business development side of our, our, of our home. Sure. And really how are we looking for the right clients that fit PM? Yeah. How, again, when you look at, uh, BD, it’s a relationship. Mm. So who are those owners? Who are the asset managers? What do their teams look like? Is that a right fit? And how can we help them grow? So that’s really the act – acquisition of the client and the customer. And then when we get to the property level – Right. Then as an enterprise, as a support center, what we’re looking to do is how do we use data, which is the, the heart – Yeah. Of revenue optimization. Sure. How are you using that data to make sure that we’re pulling through every step of the guest journey? So from the time again, acquisition of a customer. Right. So now not an owner, but that actual guest that’s gonna be staying at our properties, what does that customer journey look like? How do we find the right customer? We have a very diversified portfolio – Oh, yeah. For each one of our assets in the portfolio, ensuring that they convert. And then once they’re there in their stay, are we pulling through on all the experiences they expect? Whether it’s an independent hotel and the experiences that come along or for the brands and the brand standards. And then once our guests leave, how do we make sure that we are still speaking to them – uh-huh. And making sure that they return? Ryan Embree: I love how you walk through the entire guest experience. I think sometimes we get caught up just thinking about one or two elements of it. Right. But it really does start. I mean, the hot topic right now is that AI visibility, right? Absolutely. And being bound, uh, because our travelers are changing the way that they’re searching for hotels and doing their research. So, uh, it’s super, super important there. We’re in Nashville, Erica, uh, no stranger for PM Hotel Group. Yes. Uh, you guys just, uh – Very excited. Assumed management, 12 properties. Yes. Uh, what do you lo – like, um, from a Nashville market standpoint? I mean, this has just been such a hot market right now in hospitality. Uh, but also, you know, a big threshold of, uh, exciting 80 plus hotels for PM Hotel Group? Erica Lipscomb: Yes. We’re very excited to have the 12 hotels that, from Pinnacle that joined our portfolio. And that’s really our sweet spot, right? Finding those type of assets that fit our growth in our platform, and that we can make sure that we’re optimizing on their revenue, as well as excellent customer experience and guest operations experience. So what I really like about Nashville, and it’s not a new growth. Right. You know, Nashville never stopped growing, right? Where the, where the rest of the world really has struggled even, you know, six years ago. Through COVID. Nashville didn’t, right? Ryan Embree: It was red hot. Erica Lipscomb: But what most people think about when you hear Nashville, they’re really just thinking it’s an entertainment city. That’s not just all Nashville is. So when we peel it back and take a look at the segmentation and what’s driving Nashville, you do still have that customer that is true corporate business. And you still have conventions and groups. I was just in a group maximization winning group seminar just not too long ago. And in that breakout session, we really talk about group continues to still grow. Oh, yeah. And when you take a look at the first half of this year, that growth is really happening not only just in convention centers, but those hotels that have group meetings. Even when you take a look at those assets, what’s interesting is the growth is not just in the hotel that has most of the group, but if you are affiliated. You’re feeling that demand. Leveraging the demand and continuing to drive occupancy and ADR. Yeah, absolutely. So that’s why we’re still excited about Nashville. It’s one of those markets that continues to do well, not just in entertainment, but on the corporate business transient side, as well as group side. Ryan Embree: It’s a perfect destination. That’s why we got almost a thousand hoteliers here at the hotel data conference. Erica Lipscomb: That’s sold out again this year. Ryan Embree: Absolutely. Well, any. I mean, I can tell just by the conversation we’re having, very passionate about your work. Any projects you’re particularly fired up about right now? Erica Lipscomb: The project I’m probably most interested in is what I was hired for is to really continue to evolve commercial strategy. So commercial strategy is not just looking at every discipline in a silo. They’re all very important to revenue optimization. But how do we now continue to go from just having the commercial conversations, but also leverage the experience in each discipline? So our customers, when they look at our hotels, And they look at that curse customer journey that we just walked through – Right. They’re not looking at sales, revenue, marketing, distribution, operations. They’re looking at their holistic experience. Yeah. And so why not make sure that we internally stop looking at how well each d- division does and, and, and our, each siloed discipline, but let’s look through the lens of a gu – of a customer. Yeah. What’s that experience look like? And then how do we all play a part of it? Yeah. Exactly. So that’s what I’m excited about. And using, continuing to use AI. Yeah. How do we make sure that we’re leveraging commercial? Yeah. And then making sure that our use of AI is making our teams much more efficient – Mm. And effective in h – in how we run our businesses. Ryan Embree: That’s what I was gonna say. It’s, it’s such an inflection point, and I’m sure very exciting for, for your job with the technology in hand. Now you’ve got the power to, uh, break down those silos, right? Absolutely. Create efficiencies there. Yes. Uh, well, as we wrap up, you know, we always. One of the things here that we love to do at the Hotel Data Conference is try to predict the future, right? Forecasting, everybody. It’s a, it’s an impossible job, but we do it every single year. Right. Uh, you know, so from a commercial strategy standpoint, I know you, you, you just mentioned the projects you’re working on, but what’s your vision for PM Hotel Group as we kind of go into the latter part of the 2020s? Erica Lipscomb: So latter part of the 2020s, I think that the company’s vision is to really leverage the portfolio and the diversity of the portfolio. We saw that growth that we had just here in Nashville. I’m sure you saw the news that Reset our first brand to enter Marriott’s or outdoor collection. Yeah. We’ve noticed that when you continue to diversify and not really just say, okay, we are just this type of company, making sure that we’re leveraging the expertise of our team. Mm-hmm. We can be many things – Yeah. To many customers. Yeah. And so lev – continue that leverage, that growth, but we do see that growth continue to be in experiences. Yeah. Right? So every brand is rolling out how they’re working with experiences. But what we do see, that lifestyle, outdoor – Oh, yeah. Experiences. We’ve had our first entree into it, and we’re gonna continue to grow. Ryan Embree: Awesome. We’re excited to watch that growth, and yeah, that experiential travel continues to be something, conversations we’re having here, prioritizing, that’s what the guests are prioritizing travelers are. Congratulations on all this. We continue to watch it with PM Hotel Group. Thanks, Erica. Erica Lipscomb: Thank you. Ryan Embree: Hello, everyone. Ryan Embree here with The Suite Spot. We are live on location at the 2026 Hotel Data Conference. I am here with Max Spangler, VP of Technology at Charlestown Hotel. Max, we know you’re on a panel tomorrow. We’ll talk about that in a second, but thanks for taking the time to join us. Max Spangler: Absolutely. thanks for hosting me, Ryan. Ryan Embree: Yeah, Gotel Data Conference. Name of the game, data. We’re gonna talk about, obviously, your role and, and where data plays into that. But first, you come to a conference like this, what’s the expectation? What do you hope to get out of it? And maybe when you’re a couple weeks down the line, looking back on the conference, that was a success. Max Spangler: Yeah, you know, for me, I spend a lot of time at conferences that are very narrow in scope, right? Sure. Whether it’s high tech or the hospitality show, or even technology conferences that are outside of hospitality. Sure. So coming to HDC is always great. It’s always refreshing. The keynote panel in the beginning always gives me, hopefully, optimism. And this morning, it was very optimistic – Yes. About the way things are going. So I’m thankful for that. But it’s great to hear from commercial peers how they’re using data, how they’re surfacing insights, what tools they’re using, and how they’re turning it actionable. I mean, I think for me, as someone who spends a lot of time staring at screens, developing tools, looking at dashboards, hearing from people that actually depend on this information – Yeah. So crucially is really refreshing. So I get to, like, cut through the noise a little bit and hear what’s working, and hopefully hear what’s not. Ryan Embree: Yeah, and that’s what leads to your panel tomorrow, connecting AI to commercial strategy. Yeah. Uh, maybe give our sweet spot listeners a little bit of sneak peek and maybe your thoughts on the subject. Max Spangler: We’ve got a great panel tomorrow. Super stoked for it. You know, so we, we had a pre-cause you tend to do with those panels. Right. And as a result of that, we decided to zoom out a little bit, which I though was important. So commercial still is the through line, as you would expect at HTC, but given the man – the, the members that are on the panel, we’ve got some people that, you know, are on the, the, the revenue management side. We’ve got some people from HFTP. Um, you’ve got me as an independent operator. It w- we felt, we felt it really important to say, “Let’s, let’s zoom out. Let’s take a pause and, like, let’s look at where the industry is holistically.” Sure. And so the questions are really driving off that. So you’ll find that, um, there’s insights about a year from now, what would we like to be doing differently, right? How are we driving ac- actionable insights? What KPIs are important? What KPIs are important? Yeah. Things like what’s the difference between automation versus th- this new agentic era? Mm. So I think it, um, I’m actually really excited for it. The panel’s great, and I think you’re gonna get some, some really interesting insights from a variety of different opinions. Ryan Embree: Yeah. And what we talked about is so much can change. Yeah. And you could talk about what could happen in a year. I mean, that could be a couple cycles with technology right now. And that’s why I, I was really looking forward this conversation, Max. Yeah. Because, you know, I get industry leaders, sometimes brand leaders, but you’re, you’re in it every single day, right? Yeah. Uh, VP of technology. Yep. Where do you think we are in the AI adoption – Yeah. Uh, uh, cycle? And then maybe zoom in a little bit on Charlestown Hotels. Max Spangler: Yeah. So if we, if we look at sort of where things are globally for the state of AI, I think obviously in the technology space, it’s an existential crisis, right? Right. I mean, I think you see that in, in jobs reports. I think you obviously see it in the way that they’re measuring AI as an accelerant. Yeah. You know, so, uh, friends of mine that work for tech companies, they’re seeing their time to release production code going from five weeks, four weeks down to one week. Wow. It’s easy for them to measure. It’s easy for them to see the outcomes for us. Yeah. I think it, it is ultimately a little bit more difficult. For Charlestown, you know, we think it’s really important to keep hospitality at the center of what we’re doing, right? And so we’re not parading around trying to be an AI company or a SaaS company. We firmly believe people and hospitality at the center of, is gonna be at the center of what we do.m. How do we use AI to power that? Whether it’s through efficiencies, you know, through maybe more sophisticated RMS, through, you know, generative guest insights. How do we make sure that we’re being discovered when people are asking what’s the best hotel in downtown Charleston, South Carolina? Those are really hard questions to answer. No one’s got it figured out. But the conversations that are happening here are super encouraging because I think there is a lot of people admitting that and coming together to try to find, um, the best path forward. Ryan Embree: And you were, this is not your first per – podcast that you’ve been on recently. I saw you, uh, on CoStar News Hotel podcast where you talked about escaping hospitality’s AI hype echo chamber. Yeah, yeah. What’s your thoughts on that? And maybe how do we avoid doing that here in, in spaces like this? Max Spangler: I mean, it’s, if you go on LinkedIn, you can feel like, you know, FOMO is like a- absolutely crushing you, right? Right. Everyone is, like, piloting something new. Right. Everyone is, is advancing seemingly at the speed of light. It’s really important to come to a conference like HTC, uh, to get a real life temperature check with what people are doing and how they’re doing it. There is a tremendous amount of hype. There’s a tremendous amount of potential, but I think for a lot of us, and especially from someone sitting in the seat of an operator, you have to be very disciplined. Yes. You know, you have to have a step-by-step sequence of how you’re actually gonna accomplish this. It’s okay to introduce a little bit of chaos. We’ve done that in the early days. I mean, if you go back, you know, to 2023, 2024, we’re experimenting with all the frontier models. But eventually, we wanted to collapse that into a unified choice, pick one model so that we can move forward and start measuring, you know, are our team members crawling? Who’s walking? Who’s running? How do we devise resources to help kind of get everyone on the same page, march in the same direction, and get better at this? Yeah. And so that, that’s, that’s been our strategy. And fortunately, like, that’s what I’m hearing here at the conference. Ryan Embree: And the motivation for implementing AI can’t come out of fear of we’re not doing enough. Yeah. Or, you know, we’re just, that FOMO feeling that you’re talking about, it has to have, what you said, discipline and direction. Yeah. And Max Spangler: Ryan, like, fear is a huge part. I mean, that’s one of the things that we’re constantly up against. There’s. I, I think the, the negative attitude and apprehension towards AI is only gonna continue to grow over time, right? Just like the excitement over it is gonna continue to grow. Yeah. Same thing’s true for the negative. I mean, you have people that absolutely have their head in the sand, which is okay. Right. Um, for, for certain reasons, you have people that obviously have negative feelings about it because of the socio – uh, economic impact. Sure. Companies potentially might be laying off job just Placement or replacement as a result of LLMs and the technologies that they introduce. There’s the environmental factors. So, like, all those things are absolutely true. We don’t think it’s, as Charlestown, our responsibility to sort of correct that. Right. But we do wanna make sure our associates, team members, and corporate, and corporate leadership team know this isn’t going anywhere. Yeah. It’s fundamental core to the business, and we’re gonna make an investment into our teams to make sure that they’re prepared for this new wave, whatever it looks like. Ryan Embree: It’s exciting times. And it’s okay to experiment fail sometimes, because that, that’ll show you some lessons too. Sure. Max Spangler: Yeah, we. Yeah, we’ve run so many pilots. We’ve had so many things fail. We’ve incinerated millions of tokens and subsequently thousands of dollars as a result of – Yeah. Um, so many pilots, but we’ve learned a lot. Yeah. Uh, and we’re in a much better spot as a result of it. You have to be willing to take risks, especially now. I do believe, like, no one’s gonna be left behind yet, but there is absolutely an advantage to being a first mover. And I think the companies that are at least experimenting and building AI fluency for their teams are gonna be much better, uh, much farther along than everybody else. Ryan Embree: 100%. And, you know, one of those spaces is, is the data, right? That’s, I mean, that’s the name of the game of this conference here. Yeah. How are some ways are you leveraging data to kind of – Yeah. Grow Charlestown hotels or even just create efficiencies? Max Spangler: Yeah. So for us, it, it, it is a challenge to think about the kind of company that we are. We focus mostly on the independent space. Mm-hmm. So we don’t have sort of the technology through line like the brands have where – Sure. You know, they can force a certain PMS, POS, CRS, like, it’s very clean and organized and scalable that way. Yeah. For us, you know, when we come into a new hotel operating environment, in most cases, technology hasn’t been a major form of investment, right? I mean, most people don’t come to Charlestown hotels with a great performing asset. They’re like, “We’re in trouble. We need your help.” Right. So then I come in, you know, from the technology perspective and it’s like, okay, this is difficult. How are we gonna extract information, put it into a centralized place, be able to sort of layer a, a, a, a BI tool or reporting package on top of it to actually surface the insights so these one-off owner operators can get the insights that, like, a company like Charlestown Hotels can deliver at scale with all the independent properties and things we’ve learned across the secondary and tertiary markets that we work in. Max Spangler: So, I mean, to put it simply for us, it is about having, like, a central data repository or warehouse. Sure. I mean, there’s plenty out there. Databricks, Snowflake. We’re a BigQuery customer. We do a lot with Google. Um, but it is, you know, if, if you think about where things are going to bring it back to AI, so much of the conversation surrounds having a good data foundation, because AI is an accelerant. If you have bad data, it’s gonna accelerate you to bad outcomes more quickly. Yeah, that’s a great point. If you have a bad business strategy, it’s gonna optimize for the wrong KPIs. So for us, it is very much about having solid fundamentals. Yeah. That’s not a reason for you to stop, right? It’s just more a reason for you to proceed cautiously. Ryan Embree: Absolutely. And, you know, you do it right. All of a sudden, you get that personalization, which, you know, hospitality’s been really the last decade – Yeah. Has been striving so much for to get that personalization within the guest experience. So as we wrap up, you know, we always like to. I know this is gonna be difficult because, like we said, things change so quickly in the tech space. Yeah. But what’s your vision for Charleston Hotels from a technology perspective? Max Spangler: Yeah, great question. I thought you were gonna ask me a hard one, like, what’s my favorite color? But, uh, no, for, for. Vision for technology, you know, for us, as long as we keep, like, hospitality at the center – Yeah. As our north star, that really does simplify things for us. It is gonna be difficult. There’s, you know, obviously a whole host of different frontier models you have to choose from. Tokenomics is gonna continue to be a big part. People talk about ROI with LLMs, but no one’s really talking about the expense – Yeah. And expenses continue to grow. Great point. Right? So we’re, we’re focused really on, you know, not only the, the ROI from some of the LLM tools, but, but obviously the tremendous cost that’s associated with running them at scale. But as long as we keep people and human beings at the center, reducing mundane work, admin tasks, friction so that our people can spend less time in front of screens and just be more hospitable, I think that really is the vision. Technology’s gonna support that. It’s gonna hopefully be more invisible to the people that come to hospitality. They didn’t come to, like, move information around – Right. Push paper or spend time in front of a computer. They spent it to, like, be empathetic, to be excited – Yeah. To surprise and delight. And so our goal, that’s our north star, and technology’s gonna be there to support it. Ryan Embree: Yeah, I mean, some industries, you’re, you’re right, are gonna be completely flipped upside down – Yeah. With this technology. But hospitality, we have that advantage of being a people first industry, so. Max Spangler: I, I think it’s, like, the, the key differentiator, and it honestly, it’s like, hospitality has an opportunity to have a really strong opinion. As so many industries are completely rolled over by this AI wave – Yeah. Hospitality can actually say, “No, you know what? People are…” And people in hospitality are at the center, and so as there is potentially more AI backlash and people are seeking more authentic experiences – Right. With people and connections – Yeah. I think it’s, it’s gonna be a great benefit to our industry. Max Spangler: Yeah, and we’ve seen from the data, experiences still seem t be – Yeah. I think that’s gonna grow. Yeah. Ryan Embree: Yeah. Agreed. Uh, Max, appreciate the time. Thank you. Uh, we’ll keep an eye on Charleston Hotels and everything you’re doing over there. Great. Congratulations. Max Spangler: Thank you. Ryan Embree: Hello, Everyone. Ryan Embree here with The Suite Spot. We’re live on location at the Hotel Data Conference 2026 here with Sam Trotter, Head of Digital Marketing for Indigo Road Hospitality Group. Sam, thanks for taking some time. Sam Trotter: Thanks for having me here. Yeah. I’m excited to be here at the Hotel Data Conference. Ryan Embree: It’s our first time here, but you said you’re, you’re a pro. You’ve been here for many years. Yeah. What does a successful hotel data conference look like for you and some of the takeaways that you look for? Sam Trotter: I really love having a good sense of what’s gonna happen next year. So you get some really great data here where you actually can take to your business planning sessions and use and say, “Hey, you know, I have this from the data conference, and they’re forecasting this growth in this market.” And you have something tangible. Yeah. So you’re about to head into budget season. Yeah. So having that in hand is really, really nice. Ryan Embree: That’s a big part of it. I mean, budget season, you gotta make those operation efficiency. We talked about the margins, how tight those are right now, especially in hospitality. One of the ways that hospitality’s changing right now is through AI search. You were on a panel here. For those that weren’t able to join us here in Nashville, maybe unpack that topic a little bit, because it’d certainly be top of mind for a lot of hoteliers right now. Sam Trotter: Well, it was really fun. It was a packed house, so a lot of interest in it. There’s a lot to talk about. I think we did a little bit of an intro to the topic, just so that everybody was sort of on the same page. But this is a new thing that we’re all having to adapt to. And we’re gonna have to focus on this. And in the panel, I said, “This feels a lot like 2006 when SEO was becoming a big thing.” And I remember I hired this French couple to do our SEO for this hotel that we were opening. It was like $10,000. In 2006. And it felt kinda like magic. Yeah. You know, like, what are they, what are they actually gonna do, right? And so it’s really tough. Who do you listen to? What actually works? And it was a great panel. And there’s no main takeaway other than we’re doing a lot of AB tests. We’re trying to figure out what works. I’m looking at the dashboards from our different properties. Who’s doing well? Who’s not? Yeah. And trying to pivot. And so we’re at this really interesting phase where it’s not really clear, right? Everybody’s telling us different things. Who do you listen to? So I honestly think it’s really exciting. Ryan Embree: The good news is it’s a challenge that a lot of people are attacking at once, right? And that’s where you’re gonna kind of find maybe lessons learned, even in those failures. So I think it is interesting because ultimately what happened with SEO is, like, there became a little bit of of a game plan that you could attack it with, right? That people are still trying to kind of balance. And then there were switches, right? That’s the other thing, is you could attack it one way and then all of a sudden, next week, algorithms change and it’s back to square one. So it was very, very interesting. But I think it’s events like this and panels that you’re on, Sam, that help kind of. Where everyone’s going through this right now. And to try to get through the weeds on it and try to figure out what is a good course of action here. And it changes so quickly. I think AI gets a spotlight, obviously, for good reason because it’s just this up and coming technology. But digital marketing also feels like it’s fast changing and evolving. And it’s been doing that for the past decade. You think about social media updates and everything like that. Yeah. I guess, how do you view digital marketing right now from a strategic standpoint and, and how hoteliers should be embracing and, you know, maybe investing in It? Sam Trotter: So that was a big question, right? Ryan Embree: Yes, sorry. Sam Trotter: When I have new marketers join, junior marketers, I always tell them there’s really no such thing as an expert anymore. Because it’s gonna change next year. Right? Ryan Embree: Great point. Sam Trotter: There are certain fundamentals that will help you no matter what, from 10 years from now, they’ll always be in play. I think what’s really interesting now with AI is I feel like there’s more emphasis on brand and category ownership. So if the AI is the most educated person in the entire world about hotels in Nashville. I mean, that’s what it is. Sure. It’s the most educated person in Nashville. What do you wanna teach it? And so if you’re teaching it, I have a pool and a fitness center, that doesn’t really help, right? ‘Cause now you’re just the same. And so what category can you own? Can you be the wellness hotel of Nashville? And if you’re the wellness hotel of Nashville, what that looks like is everything we say and we do reflects that. So I have spa packages, we have spa activations, we have a spa month. We have an amazing spa. We have spa content. We have spa creators that come in. And so when you’re doing that, all of a sudden the AI’s like, “Okay, no, this is the spa hotel of Nashville.” Because it’s, there’s evidence. Yeah. Right? And so I think there’s gonna be more emphasis on this category ownership, right? More than ever. And that boils back down to your brand. Ryan Embree: No, I love that. I think that’s a great explanation to someone who might feel overwhelmed in this right now. But those searches also could get very specific, right? I’m looking for a place that’s pet friendly, that is dedicated to wellness, where I’ve got my family coming to. So that’s where it gets a little bit tricky of the categories could turn into subcategories and then very, very niche. But it’s also the beauty of it, I think on the other side, is that your travelers are gonna be able to hopefully find the right hotel for them and what they’re looking for. Sam Trotter: So going back to your question, you asked me about social media. Because things are changing so fast, the, what we don’t really realize, and we don’t talk about, is the number one AI that we talk to is Google’s AI overview. That’s the one that when you have a long search, it defaults to, right? And it is weighing YouTube more than any other social platform – Great point. Because they’re not giving access. Right? So TikTok’s not giving them access. So now all of a sudden, YouTube is like this big player. And so we’ve got 76 locations. How do you scale YouTube? Yeah. And so, you know, we’re trying to figure this out in real time, and it’s a lot. There’s a lot of change happening. Ryan Embree: No, that’s a great point, what you said about Google, because a lot of people might be listening to this being like, “Well, I’m not, I’m not really looking, or I’m not using AI in my everyday life.” Well, Google’s really, you know, that AI overview, you are using, right? And it’s just, it’s gonna become more and more, whether we know it or not, a part of our life, you know? So that’s a different conversation. You know, Sam, Indigo Road Hospitality Group, you just mentioned tons of locations. What are some of the projects you’re most excited about that you’re working on right now? Sam Trotter: So, we have amazing locations, and there’s so many that are really interesting that we have coming up. We’re dabbling in more and more to membership clubs. Which is something that, we have one right now in Bentonville, and then by the end of the year, we’ll have two more. So we’re going from zero to three in a pretty short amount of time. It’ll be like a year and two months, we’ll go from zero to three. So it’s something that has been really fun to learn about, and there’s new platforms to learn about. So that’s really exciting. And then, I’m working on some fun data projects too, fun to me. I’m trying to set us up to have our own loyalty program. And so I’ve got some cool things in the works. So I’m really excited about that because we have a diverse portfolio. We have coffee shops and restaurants and hotels. And venues and how do you get them all to talk? Right? How do we put them all in one place, but have them separate? How can we share notes? How can we improve the guest experience? So there’s a lot of really cool things that are happening now. And one of the benefits of AI is partners are, are improving their platforms faster than ever. Oh, yeah. Which is fun if you have the right partners. And they are doing it. Ryan Embree: Yeah. I mean, and loyalty programs, you also learn more about your guests and hopefully create personalization, which is, you know, a topic that has been in hospitality. But we’re getting closer and closer, I feel like, to what we may have talked about five years ago at a conference like this. Be like, “There might be a time where we could do this, and now with the power of AI, it, it’s possible.” Yeah. Well, as we wrap up, kind of what’s your. I know we just talked about the future, but, and it’s hard to predict, but what would be kind of your vision for the future, in your role at Indigo Hospitality Group? Sam Trotter: I would say that, I guess thinking more optimistically, ultimately, it’s gonna be about the guest experience. It’s gonna be about the surprise and delight. It’s gonna be about having great employees who are happy to be where they’re at and that wanna be there. And the best marketing is a great experience, right? So what’s my role in that? You know, how can I help operations do their thing? And that’s the foundation of everything. At the end of the day, I think that’s it. Ryan Embree: There is a, there is a comfort, Sam, to being in an industry that we knew can only be disrupted so much by AI, but at the end of the day, it is gonna still come down to people serving people and creating those memorable experiences, and hopefully AI gives the opportunity to do. Sam Trotter: I have a anti-trend for you, right? Okay. So we’re here at, at the Grand Hyatt. There’s no kiosks, right? Check in. There’s still front desk people. 10 years ago at the hotel data conference, I think we would’ve though it was all kiosks. So hospitality has reigned supreme, and I think that’s the future. Ryan Embree: Yeah for, they say hospitality is the first ever industry and it’ll be here for a long time. So Sam, we appreciate it. We’re gonna watch you and, and everything you’re doing over there. We appreciate you taking some time with us. Sam Trotter: Thank you you so much. This was a lot of fun. All right. Ryan Embree: To join our loyalty program, be sure to subscribe and give us a five-star rating on iTunes. Suite Spot is produced by Travel Media Group. Our editor is Brandon Bell with cover art by Bary Gordon. I’m your host, Ryan Embree, and we hope you enjoyed your stay.

Avec Dr Ahmed Moussa, néonatalogiste, professeur au département de pédiatrie de la Faculté de médecine de l'Université de Montréal, clinicien-chercheur au Centre de recherche en pédagogie de la santé (CRPS), et Clara Dallaire, candidate au Doctorat d'éthique clinique, patiente-partenaire et co-responsable du Bureau du partenariat patients-familles-communauté en recherche, nous allons:définir ce qu'est le curriculum caché par rapport aux curriculums formel et informel en milieu d'apprentissage;comprendre son impact dans la formation des apprenantes et des apprenants et discuter de ses diverses influences et biais implicites;apprendre à reconnaître le curriculum caché dans son propre milieu et à adresser la situation via des stratégies de communication efficaces, le tout permettant d'en minimiser les impacts négatifs.Références:Lawrence C, Mhlaba T, Stewart KA, Moletsane R, Gaede B, Moshabela M. The Hidden Curricula of Medical Education: A Scoping Review. Acad Med. 2018 Apr;93(4):648-656. Parra Larrotta S, Hernández Rincón EH, Niño Correa D, Jaimes Peñuela CL, Romero Tapia AE. Effects of the Hidden Curriculum in Medical Education: Scoping Review. JMIR Med Educ. 2025 Sep 15;11:e68481.Meyer R, Archer E, Smit L. The Positive Influence of the Hidden Curriculum in Medical Education: A Scoping Review. Med Sci Educ. 2025 Apr 11;35(3):1817-1826. Centre de recherche en pédagogie de la santé (CRS). Faculté de médecine de l'Université de Montréal. https://crps.umontreal.ca/ Centre de pédagogie appliquée en sciences de la santé (CPASS). Ateliers de formation en pédagogie: https://catalogue.cpass.umontreal.ca/Consortium national de formation en santé (CNFS). Ateliers de pédagogie en ligne: https://www.cnfs.ca/professionnels/liste-des-ateliers-en-ligne Les invité(e)s et l'animatrice ne déclarent aucun conflit d'intérêt.Idée originale, réalisation et révision, animation et gestion des réseaux sociaux: Émilie Roy-St-PierreCaptation et montage: Philippe Lacroix (depuis janvier 2024), spécialiste en audiovisuel, et Antoine Palardy, (depuis octobre 2025) technicien en audiovisuelConseillère en communication: Pascale Chatagnier (depuis mai 2025) ; Katrine Louis-Seize (janvier 2024 à mai 2025)Technopédagogue: Carl-Philippe Sauvé (depuis janvier 2026)Logo: Équipe des communications et du graphisme du CHU Sainte-JustineMusique: Samuel RossCollègues, ami(e)s et famille, merci pour votre précieux soutien. © 2024-2026, CHU Sainte-Justine. Tous droits réservés.Merci pour l'écoute! Allez mettre une réaction sur vos épisodes préférés, partagez la bonne nouvelle sur Facebook/Instagram et abonnez-vous pour ne rien manquer

Welcome back my friends, this week we have a HEFTY new session that brings Teniak in the guest mix to celebrate his epic new release on the legendary Skamele! As always, Bad Syntax kicks thins off with the resident mix and tune reviews. Lock it in, the weekend has begun! Subfuze - Avalanche / Brash Out now on Abducted LTDDownload / Stream: bestdrumandbass.com/altd143/Supported by: Gydra, Manta, Doc Scott, Stonx, MV, Akrom, Pish Posh, DJ Odi, ESKR, Bad Ace, Nox, MYGR, The In Kill, Sindicate, Bytecode, Korax, Protoss, Jane Doe DNB, Guddah, Quannum Logic, ARI-ON, Titanz, Metric, Hijk, Nightstalker, Insom, Unknown Konflikt, SeanTron, Autopsy, Octane Amy, Critical Control Point, Lee UHF, Subconscious BSC, The d34d b34t, Ollie Duracell, Crackindomes, Confusion, CRS , Affirmation, J. Augustus, Lennart Hoffmann, Warlock, BassDrive.com, Inside DnB, Sinuous Recordings and more!Subscribe to the podcast: bestdnb.com/podcast

Techno Dance 2026 Leto @ DJ Глюк 1. ADAM SELLOUK, AVIV BENS - Killa (Original Mix) 2. Max Styler - Body Shake (Extended Mix) 3. Ronnie Spiteri - Beccas Booty (Original Mix) 4. Charmes, ED_PRJCT - Mine (Extended Mix) 5. ZEBSONIC - Miami (Extended Mix) 6. Chuckie, MC Ambush, Mosimann - Move It 2 The Drum (Extended Mix) 7. Perpetual Motion, Low Steppa - Keep On Dancin (Extended Mix) 8. Skepta, Wiley - I'm Ready (Sammy Porter Dub) 9. Avilo, AK RENNY - Low (feat. AK RENNY) (Extended Mix) 10. Denero - What Is Love (Extended) (Original Mix) 11. PJAMA SAM - Diabla (Extended Mix) 12. Florent Feltz - Blue Martini (Extended Mix) 13. Late London - Double The Time (Original Mix) 14. Ronnie Spiteri - Double Up (Original Mix) 15. CRS-1, NISOS - Better Hide Your Wallet (feat. Michael Mathers) (Explicit Mix) 16. Streetmake - Like Dat (Extended)

Tracklist and more info: https://www.bestdrumandbass.com/podcast605/Another week full of absolute bangers my friends! New comer Filthy Lad steps into the guest mix this week with an absolutely tearing mix full of heaviness, and you know Bad Syntax comes with the freshest dnb on the block. Lock it in, rock it out. The weekend is here! Subfuze - Avalanche / Brash Out now on Abducted LTDDownload / Stream: bestdrumandbass.com/altd143/Supported by: Gydra, Manta, Doc Scott, Stonx, MV, Akrom, Pish Posh, DJ Odi, ESKR, Bad Ace, Nox, MYGR, The In Kill, Sindicate, Bytecode, Korax, Protoss, Jane Doe DNB, Guddah, Quannum Logic, ARI-ON, Titanz, Metric, Hijk, Nightstalker, Insom, Unknown Konflikt, SeanTron, Autopsy, Octane Amy, Critical Control Point, Lee UHF, Subconscious BSC, The d34d b34t, Ollie Duracell, Crackindomes, Confusion, CRS , Affirmation, J. Augustus, Lennart Hoffmann, Warlock, BassDrive.com, Inside DnB, Sinuous Recordings and more!Subscribe to the podcast: bestdnb.com/podcast

In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs. Matthew Frank and Jieqing Zhu on their latest articles published in volume 147 issue 22 of Blood. Dr. Frank discusses "How I treat HLH-like toxicities after immune effector cell therapy", in which the two cases presented emphasize the need for early identification, the use of anticytokine therapy with either emapalumab or ruxolitinib when organ toxicities worsen despite conventional CRS-directed treatment, and the need for ancillary supportive care as central to success. Dr. Zhu shares insights from "Structural Basis of HPA-1 a Alloimmunization in FNAIT and Allosteric Regulation of Integrin Conformation" where they probed the structure-function relationships underpinning interactions of alloantibodies against the most common target, human platelet antigen 1a (HPA-1a). Their data can help explain why some alloantibodies cause severe hemorrhagic FNAIT while others result in milder, asymptomatic thrombocytopenia.

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tracklist and more info: https://www.bestdrumandbass.com/podcast604/YO my friends, we are back at it with another week of heavy hitters! This week we have Brijawi in the guest mix coming to rock with us, and you know in the resident seat as usual is Bad Syntax bringing the freshest unreleased madness. Lock it in, its time to blast off.Subfuze - Avalanche / Brash Out now on Abducted LTDDownload / Stream: bestdrumandbass.com/altd143/Supported by: Gydra, Manta, Doc Scott, Stonx, MV, Akrom, Pish Posh, DJ Odi, ESKR, Bad Ace, Nox, MYGR, The In Kill, Sindicate, Bytecode, Korax, Protoss, Jane Doe DNB, Guddah, Quannum Logic, ARI-ON, Titanz, Metric, Hijk, Nightstalker, Insom, Unknown Konflikt, SeanTron, Autopsy, Octane Amy, Critical Control Point, Lee UHF, Subconscious BSC, The d34d b34t, Ollie Duracell, Crackindomes, Confusion, CRS , Affirmation, J. Augustus, Lennart Hoffmann, Warlock, BassDrive.com, Inside DnB, Sinuous Recordings and more!Subscribe to the podcast: bestdnb.com/podcast

The House passes a CR with two months left on the clock.A punt is a concession you make when you've run out of downs. The House made this one on first down. With more than two months left in the fiscal year and none of the twelve appropriations bills finished, it passed a continuing resolution funding the government at fiscal year 2026 levels through December 4th, largely on party lines. Appropriations Chair Tom Cole calls the bill clean. Steve Ellis and TCS Director of Research and Policy Josh Sewell take that word apart. Clean means no partisan poison pills. It does not mean neutral. Extending the current base level for the Pentagon, for the Justice Department, for every agency, is a choice about priorities — just one nobody has to vote on.Then there's the White House anomalies list, transmitted before every CR. Some items are housekeeping: updating a program date, dropping funding for an inauguration three years away. Others are not. The list includes $1 billion to start building a Trump-class battleship whose design isn't finished — the same concurrent-design approach that produced an F-35 fleet fully mission capable about 30 percent of the time. It includes $3.2 billion in defense-wide procurement justified only by information available at a higher classification. And it would shield unobligated One Big Beautiful Bill Act funds from the standard 8 percent sequestration clawback, while the Pentagon sits on $89 billion of that money unspent and asks separately for $73 billion for the war with Iran.Steve and Josh also dig into Senate Majority Leader Thune's threat to fall back on reconciliation if Democrats won't deal, the Lankford-Hassan bill that would make automatic two-week CRs painful enough to keep members in town and working, and the record underneath all of it: Congress has finished all twelve appropriations bills on time four times in more than fifty years. The last was 1997.

How can bispecific antibodies be safely delivered outside the hospital? Rahul Banerjee, MD and Ajay Nooka, MD discuss outpatient step-up dosing, prophylactic tocilizumab, CRS management, and practical tips for implementing bispecific therapy in academic and community practice.  

In this podcast episode, Natalie S. Callander, MD, and Tom Martin, MD, discuss the optimal approaches for the determination of whether a patient with high-risk SMM requires treatment or observation, including: Contemporary Risk Stratification Interpreting Evidence for Early Intervention Treatment vs Observation: Patient Selection Treatment Selection and Sequencing Considerations Safety, Monitoring, and Supportive Care Implementation in Practice Shared Decision-making and Patient Communication Emerging Therapies and Clinical Trials Presenters:  Natalie S. Callander, MD Professor of Medicine Director, Myeloma Clinical and  Cellular Therapy Program University of Wisconsin Carbone  Cancer Center Madison, Wisconsin Tom Martin, MD Professor of Medicine Associate Chief, Hematology/Oncology UCSF Medical Center San Francisco, California Link to full program:https://bit.ly/4wqpYzU Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of Real Estate Real Talk, Leigh Brown, CRS, draws on her decades of real estate experience to discuss why education, community involvement, and staying informed are essential to long-term success. She takes a closer look at the growing influence of data centers on local markets and property values, and explains why REALTORS® should be actively engaged in planning and zoning conversations. Tune in to gain practical insights that will help you better advocate for your clients, strengthen your community, and stay ahead of emerging industry trends.

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry examine three Express Entry bonus-point factors that could soon be removed or refined—up to 50 points for French-language ability, 30 points for Canadian education, and 15 points for having a sibling in Canada. They explain why IRCC considers these factors weaker predictors of long-term economic success, which applicants are most exposed to the proposed changes, and how candidates should prepare before new ministerial instructions alter the Comprehensive Ranking System (CRS). Key Topics Discussed The proposed removal or refinement of French, Canadian education, and sibling bonus points Why IRCC considers these factors weaker predictors of long-term economic success Why French may remain valuable through category-based Express Entry draws Practical strategies for applicants currently relying on these additional CRS points Key Takeaways Applicants could lose up to 95 CRS points across French-language ability, Canadian education, and having a sibling in Canada if the proposed reforms are implemented. Removing the 50 French-language bonus points would not necessarily eliminate French category-based draws, which may continue offering candidates a pathway with lower CRS cut-offs. Applicants with one or two-year Canadian college credentials and those relying on sibling points may be the most exposed, while IRCC may preserve education points for certain graduate-level programs. Candidates should calculate their CRS scores without these additional points and consider strengthening their education, language ability, Canadian work experience, or earnings. Quotes from the Episode: Mark Holthe: "You cannot look at your current situation, the current rules, and then make your long-term decisions based on the way the world looks now." Alicia Backman-Beharry: "Understand if all these points for French and for siblings and for your Canadian education go away, are you still in a relatively strong position?" Links and Resources How to list your Canadian spouse in an Express Entry Application Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

At the 2026 National ICE-T Conference in Orlando, CancerNetwork® sat down with a variety of expert researchers and clinicians to discuss the latest developments in immune effector therapy across different hematologic oncology populations. Sessions at the meeting covered practical considerations for integrating CAR T-cell therapies, bispecific antibodies, and other modalities into the treatment of those with multiple myeloma, lymphoma, and other hematologic malignancies.First, Benjamin Diamond, MD, an assistant professor of Clinical Medicine, a member of the Sylvester Myeloma Institute, and a member of the Myeloma Genomic Lab at the University of Miami Miller School of Medicine, spoke about his presentation reviewing bispecific antibodies for the management of multiple myeloma. In his session, Diamond stated that bispecific T-cell engagers are altering the landscape of multiple myeloma care and will eventually become an option in the frontline setting. With many products to choose from, Diamond emphasized sequencing these novel therapies wisely and stressed aggressive infection prophylaxis as a mandatory facet of care.Next, Tiba Al Sagheer, PharmD, BCOP, BCACP, a pharmacy quality improvement coordinator for transplant and cellular therapy at Miami Cancer Institute of Baptist Health South Florida discussed her presentation focused on defining new thresholds for monitoring and mitigating toxicities associated with CAR T-cell therapy. She described considerations for balancing early toxicity intervention against the risk of blunting efficacy depending on the specific CAR T-cell product used during treatment. Ultimately, she noted that that there is still no definitive answer or threshold for initiating prophylaxis for toxicity associated with CAR T, and that differentiating between immune effector cell (IEC)–associated hemophagocytic lymphohistiocytosis (HLH)–like syndrome (IEC-HS) and cytokine release syndrome (CRS) represents an ongoing challenge in the field.Finally, Nikesh N. Shah, MD, and Carlos Silva Rondon, MD, shared their perspectives on a debate regarding the roles of bispecific antibodies and CAR T-cell therapies in relapsed/refractory follicular lymphoma. In his presentation, Shah, a hematologist-oncologist at Tampa General Hospital who specializes in hematologic malignancies, including aggressive lymphomas and acute lymphoblastic leukemia, took the position that bispecific antibodies should be used prior to CAR T-cell therapy for most patients, although both treatments have utility in the field. Silva Rondon, a hematologist, oncologist, and bone marrow transplant specialist at Moffitt Malignant Hematology and Cellular Therapy at Memorial Healthcare System/Memorial Cancer Institute in Pembroke Pines, advocated for CAR T-cell therapy during the debate but acknowledged that both modalities can make up a complementary strategy for overcoming relapsed/refractory follicular lymphoma.References Diamond B. Bispecific antibodies for the management of multiple myeloma. Presented at the 2026 National ICE-T Conference; July 18, 2026; Orlando, FL. Sagheer TA. Thresholds and therapeutics: a precision approach to CAR T toxicity management. Presented at the 2026 National ICE-T Conference; July 18, 2026; Orlando, FL. Shah N. Debate: bispecific antibodies vs CAR-T in follicular lymphoma. Presented at the 2026 National ICE-T Conference; July 18, 2026; Orlando, FL. Silva C. CAR-T cell therapy for relapsed follicular lymphoma. Presented at the 2026 National ICE-T Conference; July 18, 2026; Orlando, FL.

Tracklist and more info: https://www.bestdrumandbass.com/podcast603/ ‎RELEASE DAY IS HERE MY FRIENDS! One of my favorite up and coming artists has a brand new single and he is here in the guest mix to help promo it today. Subfuze got the sound to keep you rocking, so lock it in and go check out that new single! Subfuze - Avalanche / Brash Out now on Abducted LTDDownload / Stream: bestdrumandbass.com/altd143/Supported by: Gydra, Manta, Doc Scott, Stonx, MV, Akrom, Pish Posh, DJ Odi, ESKR, Bad Ace, Nox, MYGR, The In Kill, Sindicate, Bytecode, Korax, Protoss, Jane Doe DNB, Guddah, Quannum Logic, ARI-ON, Titanz, Metric, Hijk, Nightstalker, Insom, Unknown Konflikt, SeanTron, Autopsy, Octane Amy, Critical Control Point, Lee UHF, Subconscious BSC, The d34d b34t, Ollie Duracell, Crackindomes, Confusion, CRS , Affirmation, J. Augustus, Lennart Hoffmann, Warlock, BassDrive.com, Inside DnB, Sinuous Recordings and more!Subscribe to the podcast: bestdnb.com/podcast

In today's episode, we spoke with Joshua K. Sabari, MD. Dr Sabari is an assistant professor in the Department of Medicine at NYU Grossman School of Medicine, and director of High Reliability Organization Initiatives at NYU Langone Health's Perlmutter Cancer Center New York. In our exclusive interview, Dr Sabari discussed the complexities of managing small cell lung cancer (SCLC) across both academic and community settings, emphasizing that nothing about this disease is straightforward. He stressed the importance of rapid diagnosis and staging, ideally within 48 to 72 hours given how quickly patients can deteriorate, and noted that in his own academic practice, approximately 30% of patients never reach second-line therapy, a figure that climbs to 50% to 60% in the community setting.He highlighted 2 areas where community implementation frequently breaks down: first-line maintenance and second-line therapy. Regarding maintenance, Dr Sabari underscored the need to counsel patients about the combination of atezolizumab (Tecentriq) plus lurbinectedin (Zepzelca) from the outset of treatment, so the transition after 4 cycles of chemoimmunotherapy is not a surprise. In the second-line setting, he addressed the practical challenges of administering tarlatamab-dlle (Imdelltra), a CD3 x DLL3 bispecific T-cell engager, noting that the first 2 doses require inpatient monitoring given the risks of cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS). However, he noted that these monitoring resources may not be readily available outside of academic centers.The discussion also covered the evolving role of the multidisciplinary care team, with Dr Sabari highlighting the outsized impact of dedicated thoracic pharmacists in educating patients, monitoring for adverse effects (AEs), and intervening early, particularly with novel agents whose AE profiles are still being characterized. He shared real-world examples of coordination saves, including a radiologist who flagged early pneumonitis and a patient receiving tarlatamab who developed subtle cognitive changes that were initially missed.Finally, Dr Sabari outlined the top educational gaps for community teams: understanding the biological heterogeneity of SCLC, recognizing when and how to use emerging agents such as tarlatamab and obrixtamig (BI 764532), and developing fluency in managing novel toxicities including CRS, ICANs, and interstitial lung disease associated with antibody-drug conjugates.

In this informative episode we dived into the world of CAR T-cell therapies for multiple myeloma. In this ToxCheck episode, we focused on the available CAR-T options, including idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel), and discussed their side effects, management strategies, and the importance of patient education.   We were joined by myeloma specialists Caitlin Costello, MD, from UC San Diego Health, and Joshua Richter, MD, from Mount Sinai, who shared their insights on the acute and chronic side effects associated with CAR-T therapies. Learn about the common toxicities such as cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS), as well as the role of prophylactic treatments and the importance of bridging therapy.   This episode emphasized the critical collaboration between community oncologists and academic institutions to ensure patients receive the best care possible. Tune in to understand how to navigate the complexities of CAR-T therapies and empower your patients with the knowledge they need.   Key Topics: Overview of CAR-T therapies for multiple myeloma Common side effects: CRS and ICANS Management strategies for acute and chronic toxicities The role of prophylactic treatments Importance of communication between community and academic oncologists   Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o    Follow us on social media: •⁠  ⁠X/Twitter: https://x.com/oncbrothers  •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers  •⁠  Website: https://oncbrothers.com/    Don't forget to like, subscribe, and hit the notification bell for more episodes from the Oncology Brothers! #CARTtherapy, #MultipleMyeloma, #CRS, #ICANS, #OncologyBrothers

In this episode, Dr Sara Ann Scott and Dr Syeda Saba Kareem discuss toxicities and the safe management of bispecific antibodies used in the treatment of RRMM to improve outcomes for patients, including: The incidence of cytokine release syndrome (CRS), along with the grading system, treatment strategies, and the role of tocilizumab Neurologic toxicities like the clinical manifestation of ICANS and the ICE scoring system used to help assign grading and appropriate treatment with dexamethasone, levetiracetam, and/or high-dose methylprednisolone Infection susceptibilities associated with BCMA-targeted bispecific antibodies and how this varies for GPRC5D-directed targets throughout therapy How to set up and maintain a REMS program Get access to all of our new podcasts by subscribing to the Decera Clinical Education Podcast on Apple Podcasts, YouTube Music, or Spotify. Presenters: Syeda Saba Kareem, PharmD, BCOP Clinical Pharmacy Supervisor Malignant Hematology Moffitt Cancer Center Tampa, Florida Sara A. Scott, PharmD, BCOP Clinical Pharmacy Specialist,  Multiple Myeloma Emory Winship Cancer Institute Atlanta, Georgia Link to full program: https://bit.ly/3RUyrMx Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

320 000, c'est le nombre d'étudiants laissés sur le carreau en 2025 par la plateforme parcoursup. Une sélection à l'entrée de l'université voulue par les macronistes et appliquée avec zèle par certaines universités. Y compris celles qui ont une longue histoire de gauche, comme l'université de Nanterre. Et gare aux syndicats étudiants qui voudraient mener des actions pour débloquer les situations de ceux qu'on appelle désormais les “sans facs”. Certains militants de l'UNEF, 8 pour être plus précis, en ont fait les frais. En effet, ces derniers ont été convoqués les 29 et 30 juin derniers au commissariat de Nanterre. Selon les militants, c'est un acharnement de la part de la direction de l'établissement, qui n'avait déjà pas hésité à faire intervenir les CRS pour défaire ces occupations. L'UNEF n'entend pas lâcher la lutte pour autant. Ce d'autant que d'autres problématiques se sont rajoutées à parcours sup depuis : à commencer par la hausse des frais d'inscription et plus récemment la fin des APL pour les étudiants étrangers. Ainsi les syndicats sont de plus en plus réprimés par les directions de leurs facs alors que la situation des étudiants en France est de plus en plus catastrophique. Pour en parler, Irving Magi reçoit Hajar, trésorière de l'UNEF Nanterre.

Tracklist and more info: https://www.bestdrumandbass.com/podcast602/ Welcome back my friends, ITS MY BIRTHDAY! (Today, July 17) We are celebrating by doing what we always do, bringing the fuckin basslines direct to you! This week we have Raw Session in the guest mix rocking out, and as always your resident mix by Bad Syntax. Lock it in, and rock it out, the birthday weekend has officially begun! N.A.P.S. 2026 presented by Abducted LTDFeaturing: Acidion / Bad Syntax / Basinys / Crvtch / Dark Adaptation / Diode / Dr.Uggist / Electron-C / Eskr / Evassive / FauxRealz / Goss & Subby / Messinian / Pish Posh / Skorpion / Sodie / Spiralus / Subfuze / Zaiaku / 9 WrenchesDownload / Stream: bestdrumandbass.com/altd142/Supported by: NOISIA, DJ Aphrodite, Doc Scott, Figure, Stonx, Nightstalker, Guddah, Akrom, Metric, dela Moon, 5AH5H, Abstr4ct, Bad Ace, The In Kill, Korax, MYGR, Acidion, Nox, Kozee, Protoss, Bytecode, Titanz, Contam, GroVe, ARI-ON, Subconscious BSC, Confusion, 360 Degrees, Crackindomes, Hijk, Stonerice, Drumad, Critical Control Point, Johannes Soppa, Lee UHF, The d34d b34t, Lennart Hoffmann, Octane Amy, Ollie Duracell, Dan, SeanTron, Insom, D_E_B_T, MV, Jay, J. Augustus, Affirmation, CRS and moreSubscribe to the podcast: bestdnb.com/podcast

This week on the Midweek Takeaway, Kevin Hornsby is joined by Jeremy Skillington and Cathal Friel from Poolbeg Pharma to discuss the company's latest clinical milestone after dosing the first patient in its Phase II trial for POLB 001.The discussion covers how the treatment is designed to prevent cytokine release syndrome (CRS) in patients receiving cancer immunotherapies, the significance of Poolbeg's partnership with Johnson & Johnson, the commercial opportunity in a multi-billion-dollar market, and why management has continued to back the company with significant personal investmentDisclaimer & Declaration of InterestThis podcast may contain paid promotions, including but not limited to sponsorships, endorsements, or affiliate partnerships. The information, investment views, and recommendations provided are for general informational purposes only and should not be construed as a solicitation to buy or sell any financial products related to the companies discussed. Any opinions or comments are made to the best of the knowledge and belief of the commentators; however, no responsibility is accepted for actions based on such opinions or comments. The commentators may or may not hold investments in the companies under discussion. Listeners are encouraged to perform their own research and consult with a licensed professional before making any financial decisions based on the content of this podcast.

In this podcast episode, Donald Moore, PharmD, BCPS, BCOP, DPLA, FCCP, FASHP, and Anthony Perissinotti, PharmD, BCOP, discuss the role, efficacy, and safety of agents targeting BCMA in the personalized care of patients with multiple myeloma after disease progression on 1 or 2 previous lines of therapy, including: A Brief Overview of BCMA in Multiple Myeloma Advances in BCMA-Targeted Agents in Progressing Myeloma Selection of BCMA-Directed Therapies for Early Relapse MM Operational Challenges Faced by Oncology Pharmacists Regarding the Incorporation of BCMA-Targeted Agents in Practice Identifying and Managing Adverse Events Associated With BCMA-Directed Agents Presenters:  Donald Moore, PharmD, BCPS, BCOP, DPLA, FCCP, FASHP Clinical Oncology Pharmacy Manager Atrium Health Levine Cancer Institute Charlotte, North Carolina Anthony Perissinotti, PharmD, BCOP Hematology Clinical Pharmacist Specialist University of Michigan Ann Arbor, Michigan Link to full program:https://bit.ly/4gCsgXt Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

WOW its a HUGE week its been for the NAPS crew! We hit #5 DNB release, and even broke the top 40 of all genres! I want to start off this episode with a heartfelt thank you to everyone who helped with that. This week we have one of the stars of the release, Acidion, in the guest mix to help rock out into the weekend! Lock it in, and if you havent yet PLEASE go check the latest release linked below! N.A.P.S. 2026 presented by Abducted LTDFeaturing: Acidion / Bad Syntax / Basinys / Crvtch / Dark Adaptation / Diode / Dr.Uggist / Electron-C / Eskr / Evassive / FauxRealz / Goss & Subby / Messinian / Pish Posh / Skorpion / Sodie / Spiralus / Subfuze / Zaiaku / 9 WrenchesDownload / Stream: bestdrumandbass.com/altd142/Supported by: NOISIA, DJ Aphrodite, Doc Scott, Figure, Stonx, Nightstalker, Guddah, Akrom, Metric, dela Moon, 5AH5H, Abstr4ct, Bad Ace, The In Kill, Korax, MYGR, Acidion, Nox, Kozee, Protoss, Bytecode, Titanz, Contam, GroVe, ARI-ON, Subconscious BSC, Confusion, 360 Degrees, Crackindomes, Hijk, Stonerice, Drumad, Critical Control Point, Johannes Soppa, Lee UHF, The d34d b34t, Lennart Hoffmann, Octane Amy, Ollie Duracell, Dan, SeanTron, Insom, D_E_B_T, MV, Jay, J. Augustus, Affirmation, CRS and moreSubscribe to the podcast: bestdnb.com/podcast

In this episode of the Oncology Brothers podcast, we tackled two real-world challenging cases in diffuse large B-cell lymphoma (DLBCL) alongside two lymphoma experts — Dr. Matthew Lunning from the University of Nebraska and Dr. Gilles Salles from Memorial Sloan Kettering Cancer Center. The central question: when faced with relapsed or transformed aggressive B-cell lymphoma, how do you choose between CAR-T cell therapy and bispecific antibodies, and how do you get patients through this safely?   Key topics discussed included: The role of CAR-T cell therapy in early relapsed DLBCL based on ZUMA-7 and TRANSFORM trial data, and practical strategies for bridging and holding therapy pre- and post-apheresis to safely deliver treatment. A comparison of axicabtagene ciloleucel versus lisocabtagene maraleucel in terms of efficacy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) rates, and outpatient feasibility. Management of transformed follicular lymphoma to double-hit DLBCL in the third-line setting, including the role of glofitamab, mosunetuzumab, polatuzumab, and epcoritamab as bridges to CAR-T cell therapy. The importance of early partnership between community oncologists and tertiary care centers to ensure patients access CAR-T and bispecific therapies in a timely manner. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o  Follow us on social media: X/Twitter: https://x.com/oncbrothers  ⁠Instagram: https://www.instagram.com/oncbrothers  Website: https://oncbrothers.com/    Join us for this expert discussion on navigating the complex treatment landscape of relapsed and transformed aggressive B-cell lymphoma. Don't forget to like, subscribe, and check out our other episodes for more insights on oncology! #DLBCL, #CARTTherapy, #BispecificAntibodies, #Hematology, #OncologyBrothers  

In this episode, Kurt Thompson, CRS, shares his extensive journey in real estate, emphasizing the importance of volunteer leadership, community involvement and continuous learning for professional growth. Discover how active participation in associations like RRC can transform your career and impact your community.  

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry examine one of the most controversial elements of Canada's proposed Express Entry reforms—the planned removal of the spousal points grid that currently reduces Comprehensive Ranking System (CRS) scores for applicants with accompanying spouses. They explain how the current system penalizes many married and common-law couples, why IRCC's own economic research suggests the policy does not accurately predict immigrant success, and what applicants should consider while waiting for the proposed changes to be implemented. Key Topics Discussed How the current spousal points grid reduces CRS scores for accompanying spouses Why IRCC's own research suggests spouse factors have little impact on long-term economic success The proposed removal of the spousal points grid and what it could mean for families Practical strategies for couples deciding whether to include a spouse on an Express Entry application Key Takeaways Under the current CRS system, applicants with accompanying spouses can lose up to 40 human capital points, depending on their spouse's education, language ability, and Canadian work experience. IRCC's own longitudinal research indicates that a spouse's education, language ability, and Canadian work experience have little measurable impact on the principal applicant's long-term economic outcomes. Removing the spousal grid would allow applicants to be assessed on their own human capital rather than their spouse's qualifications, helping reduce unintended penalties for families. Although the proposed reform has been announced, applicants must continue planning under the current rules until IRCC officially implements the changes. Quotes from the Episode: Mark Holthe: "It wasn't the spouse that reduced a family's success—the system simply assumed it did." Alicia Backman-Beharry: "The evidence doesn't support the spousal grid. It really functions as a penalty that doesn't reflect actual economic outcomes." Links and Resources How to list your Canadian spouse in an Express Entry Application Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Its official, 600 episodes in the back pocket, and were only getting heavier! This week we have None Decay making their debut in the guest mix, and we also are celebrating the first annual N.A.P.S. release! If youre not familiar with the North American Producer Showcase, its about celebrating all the amazing talent we have here in North America. The release is the first in the series, and we will be giving 100% of all profits to the artists to help celebrate them. We hope youll join us in celebrating this amazing project!N.A.P.S. 2026 presented by Abducted LTDFeaturing: Acidion / Bad Syntax / Basinys / Crvtch / Dark Adaptation / Diode / Dr.Uggist / Electron-C / Eskr / Evassive / FauxRealz / Goss & Subby / Messinian / Pish Posh / Skorpion / Sodie / Spiralus / Subfuze / Zaiaku / 9 WrenchesDownload / Stream: bestdrumandbass.com/altd142/Supported by: NOISIA, DJ Aphrodite, Doc Scott, Figure, Stonx, Nightstalker, Guddah, Akrom, Metric, dela Moon, 5AH5H, Abstr4ct, Bad Ace, The In Kill, Korax, MYGR, Acidion, Nox, Kozee, Protoss, Bytecode, Titanz, Contam, GroVe, ARI-ON, Subconscious BSC, Confusion, 360 Degrees, Crackindomes, Hijk, Stonerice, Drumad, Critical Control Point, Johannes Soppa, Lee UHF, The d34d b34t, Lennart Hoffmann, Octane Amy, Ollie Duracell, Dan, SeanTron, Insom, D_E_B_T, MV, Jay, J. Augustus, Affirmation, CRS and more

Get ready for an inspiring and insightful episode of The Ash Said It Show as we sit down with a true powerhouse of the industry, Brianne Drake, who currently serves as the 2026 President of the Georgia Association of REALTORS®. As the first Black President in the 106-year history of the Georgia Association of REALTORS®, Brianne is a trailblazer whose distinguished 27-year career is defined by integrity, ethical leadership, and a deep commitment to service. Representing more than 47,000 members across the state of Georgia, Brianne shares her strategic vision for unity, professional leadership development, and the vital importance of advocacy in protecting homeownership rights. In this episode, we dive into Brianne's historic journey, exploring the milestones that allowed her to break barriers and rise as a respected leader on both the state and national levels, including her influential work as a Director for the National Association of REALTORS®. We also explore the power of political advocacy and why Brianne is so passionate about protecting private property rights, a commitment solidified by her 2025 induction into the National Association of REALTORS® RPAC Hall of Fame as a Major Investor. Beyond the politics and accolades, Brianne explains her client-first philosophy, sharing her deeply held belief that real estate is not simply about contracts or keys, but about people, families, and futures. We also celebrate her impressive professional legacy, including her 2026 recognition as one of the Georgia 100 Women of Excellence and the numerous formal resolutions honoring her contributions from the Georgia General Assembly. Whether you are a real estate agent seeking professional development, an aspiring industry leader, or a listener looking for a story of perseverance and dedication, this conversation with one of Georgia's most dynamic real estate experts is essential listening. Tune in now to learn how Brianne Drake is shaping the future of real estate. Web: https://garealtor.com/ Brianne Drake is a distinguished Georgia real estate industry leader serving as the 2026 President of the Georgia Association of REALTORS® (GAR). Representing more than 47,000 members throughout the state, she holds the historic distinction of being the first Black President in the 106-year history of the organization. As a Broker Associate and Global Real Estate Advisor with Atlanta Fine Homes Sotheby's International Realty, Brianne combines extensive market expertise with a commitment to client advocacy, integrity, and professional excellence. Brianne's professional career is defined by her deep involvement in local, state, and national REALTOR® governance and real estate policy. Her leadership portfolio includes serving as a Director for the National Association of REALTORS® (NAR) and as a dedicated member of the Membership Policy and Board Jurisdiction Committee. She previously served as the Chair of the Professional Standards Committee in 2023 and the Chair of the Professional Standards Interpretations and Procedures Advisory Board in 2024. As a champion of private property rights and industry advancement, Brianne was inducted into the NAR RPAC Hall of Fame as a Major Investor in 2025 and received the Georgia Association of REALTORS® Dick McCrudden Award in 2023 for her contributions to the REALTORS® Political Action Committee. Her professional accomplishments and impact on the Georgia real estate industry have been recognized by the Georgia General Assembly on multiple occasions. Brianne was honored on the floor of the Georgia Senate and House in 2026 through Senate Resolution 753 and House Resolution 1253, and previously in 2021, for her longstanding service to the community. In 2026, she also received the Georgia 100 Women of Excellence Resolution at the Georgia State Capitol in honor of Women's History Month. Her historical industry accolades include being named REALTOR® of the Year by the Metro South Association of REALTORS® in 2011 and 2018, as well as receiving the J.L. Christian Leadership Award in 2009 and 2011 and the President's Award in 2012. A native of Atlanta, Georgia, and an alumna of Georgia State University, Brianne utilizes a client-first philosophy that has established her as one of the state's most trusted real estate advisors. Her expertise is backed by a comprehensive suite of nationally recognized real estate designations, including ABR, AHWD, C2EX, CRS, GRI, SFR, and MRP. Through her work, she continues to provide exceptional experiences for families navigating the real estate market. "For me, real estate is not simply about contracts or keys; it's about people, families, and futures," says Brianne Drake, who remains dedicated to shaping the future of the real estate profession through advocacy and ethical leadership. - Ready to ignite the spark that levels up your entire life? Meet Ash Brown—the American powerhouse, motivational architect, and ultimate hype-woman dedicated to your personal and professional evolution. Ash is far more than a voice in the personal development space; she is a trusted ally who delivers a masterclass in real-talk wisdom and infectious energy. Whether you are navigating a crossroads or ready to scale your grandest ambitions, Ash fuels your journey with a high-octane blend of heart and hustle.

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry examine the return of job offers as a proposed factor in Express Entry and why this change could become one of the most significant elements of Canada's immigration reforms. They explain why job offer points were eliminated due to widespread LMIA fraud, how IRCC plans to reintroduce job offers through the proposed High-Wage Occupation framework, and why the new approach may benefit some applicants while leaving many essential workers behind. Key Topics Discussed Why job offer points were removed from Express Entry How LMIA fraud undermined the integrity of the system The proposed return of job offers tied to High-Wage Occupation classifications Why legitimate employers and many lower-wage essential workers may be affected by the new rules Key Takeaways Job offer points were eliminated because widespread LMIA fraud allowed individuals to purchase fraudulent job offers to gain additional CRS points. IRCC now proposes bringing job offers back through the High-Wage Occupation framework, focusing on occupations with higher national median wages. Applicants working in high-wage occupations may receive significant advantages, while many healthcare support workers, hospitality employees, and other essential occupations may receive little or no benefit. Although IRCC has outlined its direction, important details—including how qualifying job offers will be defined and how the new rules will be implemented—have not yet been finalized. Quotes from the Episode: Mark Holthe:"It wasn't the system that was broken—it was the enforcement that was broken." Alicia Backman-Beharry:"A real offer is the only offer of employment that should count under the old system or under the new system." Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Claiming Express Entry CRS points for a Job Offer in Canada Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry break down one of the most significant proposed changes to Express Entry: the new High-Wage Occupation (HWO) factor. They explain why IRCC believes pre-landing earnings are a strong predictor of economic success, how the proposed occupation-based multiplier could dramatically boost CRS scores for some applicants, and why many temporary residents—including international graduates and essential workers—could find themselves at a disadvantage. Key Topics Discussed Why IRCC is introducing the proposed High-Wage Occupation factor How occupation—not your personal salary—will determine eligibility The three proposed wage multiplier categories and how they may work Why some occupations could receive significant CRS boosts while others receive none Key Takeaways The proposed High-Wage Occupation factor is based on national median wages for occupations, not what an individual personally earns. Applicants working in higher-paying occupations may receive substantial additional CRS points under the new system. Many essential workers and international graduates in lower-wage occupations could become less competitive despite having Canadian education and work experience. Although the overall framework has been released, many implementation details—including the exact CRS points awarded—have not yet been finalized. Quotes from the Episode: Mark Holthe:"It is occupation-based, not individual-based." Alicia Backman-Beharry:"The system is not structurally reinforcing the wages of the people that we tend to devalue." Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Tracklist and more info: https://www.bestdrumandbass.com/podcast599/Woah, almost to 600 episodes, and we are ramping up for the epic N.A.P.S. 2026 release next week in the resident mix with Bad Syntax. We also have BENNIT in the guest spot with a silky smooth guest mix that will help to get your weekend started proper. Lock it in, the weekend has begun!Direct Shift ft Sez'Nah - D.Y.C.A.G.Y.S / Bankruptcy [Abducted LTD]Download / Stream: bestdrumandbass.com/altd141/Supported by: MNDSCP, Manta, X.morph, Doc Scott, Akrom, Pish Posh, Stonx, MV, Direct Shift, Unknown Konflikt, Contam, Protoss, Bytecode, Acidion, MYGR, Jane Doe DNB, SeanTron, ESKR, Nox, Insom, Confusion, Subconscious BSC, Needlenose, Hijk, Tschul, Korax, CRS, ARI-ON, Metric, Figure, Quannum Logic, Sindicate, Crackindomes, RCA Trash, J. Augustus, Jay, Lennart Hoffmann, Johannes Soppa, Octane Amy, Ollie Duracell, Dan, Murmuration Events, Lee UHF, BassDrive.com, Sinuous Recordings and moreSubscribe to the podcast: bestdnb.com/podcast  

In this episode, hosts David Millili and Steve Carran sit down with Anthony Vita, VP of Global Partnerships at Revenue Analytics, to explore how modern revenue management is becoming more accessible to independent hotels and boutique operators.Anthony shares his unconventional journey from e-commerce and luxury interiors into hospitality tech, and how that experience helped shape his perspective on data, pricing, and automation. The conversation dives into the launch and expansion of Climber in North America, and how it's aiming to level the playing field between small independent properties and large hotel groups through affordable, intelligent revenue management tools.In this episode, you'll learn: Why Climber is expanding into North America to support independent hotel operators  How Revenue Analytics is working to democratize revenue management tools that were once only available to large hotel chains  Why many independent hotels still rely on spreadsheets and “gut instinct” for pricing—and what's changing  The importance of partnerships across PMS, CRS, and hospitality tech ecosystems in scaling revenue solutions globally  How accessibility and affordability are shaping the future of revenue management for small and mid-sized properties Watch the FULL EPISODE on YouTube: https://youtu.be/3vbrnUkyHaALinks:Anthony on LinkedIn: https://www.linkedin.com/in/vitaanthony/Revenue Analytics: https://www.revenueanalytics.com/For full show notes head to: https://themodernhotelier.com/episode/291Follow on LinkedIn: https://www.linkedin.com/company/the-..Join the conversation on today's episode on The Modern Hotelier LinkedIn pageConnect with Steve and David:Steve: https://www.linkedin.com/in/%F0%9F%8E...David: https://www.linkedin.com/in/david-mil.

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry continue their series on major Express Entry reforms expected in Canada. They explain why a high CRS score may no longer guarantee a realistic path to permanent residence, and break down the growing divide between general draws and category-based draws in Express Entry. Key Topics Discussed The 169 versus 505 CRS paradox General draws versus category-based draws STEM draw blackout and category-based uncertainty High-wage occupations and future CRS changes Key Takeaways A higher CRS score does not always mean a better chance of receiving an ITA. Category-based draws can completely change the outcome for applicants with lower CRS scores. Some categories, including STEM, may remain inactive for long periods despite appearing on IRCC's list. Applicants need to understand where they stand now and prepare before CRS changes arrive. Quotes from the Episode: Mark Holthe: “If your whole plan is, ‘I will just wait for the general cutoff to drift down to my score,' the data is basically telling you that that's not a plan.” Alicia Backman-Beharry: “It is just so important now to be extremely targeted in terms of how you are planning for your future instead of passive.” Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

tracklist and more info: https://www.bestdrumandbass.com/podcast598/Welcome back my friends! we celebrate the new release from Direct Shift & Sez'Nah on Abducted LTD (that is currently in the top 40 DNB releases!) with a guest mix by Sez'Nah, alongside your usual resident madness with Bad Syntax. Lets get the weekend started!Direct Shift ft Sez'Nah - D.Y.C.A.G.Y.S / Bankruptcy [Abducted LTD]Download / Stream: bestdrumandbass.com/altd141/Supported by: MNDSCP, Manta, X.morph, Doc Scott, Akrom, Pish Posh, Stonx, MV, Direct Shift, Unknown Konflikt, Contam, Protoss, Bytecode, Acidion, MYGR, Jane Doe DNB, SeanTron, ESKR, Nox, Insom, Confusion, Subconscious BSC, Needlenose, Hijk, Tschul, Korax, CRS, ARI-ON, Metric, Figure, Quannum Logic, Sindicate, Crackindomes, RCA Trash, J. Augustus, Jay, Lennart Hoffmann, Johannes Soppa, Octane Amy, Ollie Duracell, Dan, Murmuration Events, Lee UHF, BassDrive.com, Sinuous Recordings and moreSubscribe to the podcast: bestdnb.com/podcast

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry continue their series on major Express Entry reforms expected in Canada. They explain why the public consultation on minimum eligibility may not be the reform that most affects applicants, and break down the three tracks applicants need to watch: regulatory reform, CRS changes through ministerial instructions, and category-based draws. Key Topics Discussed Three-track timeline for Express Entry reforms CRS changes versus regulatory amendments Category-based draws and public consultation High-wage occupations and future job offer points Key Takeaways The eligibility merger is important, but it is not the most urgent reform for most applicants. CRS changes could arrive quickly through ministerial instructions and may significantly affect scores. Category-based draws are running on a separate clock and may become even more important as bonus points are removed. Applicants should prepare strategically by keeping as many pathways open as possible. Quotes from the Episode: Mark Holthe: “No longer can you just submit a profile, sit back, and wait for your turn.” Alicia Backman-Beharry: “It's really a matter of being really thoughtful about what you're doing, why you're doing it, and where you want it to take you.” Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry continue their series on major Express Entry reforms expected in Canada. They break down the two-track timeline for Express Entry changes, what is expected to change quickly through ministerial instructions, what will take longer through regulatory amendments, and how applicants should assess their current strategy before the deeper reform episodes begin. Key Topics Discussed Two-track timeline for Express Entry reforms Ministerial instructions versus regulatory amendments What is staying stable in Express Entry for 2026 High-wage occupation factors and future CRS changes Key Takeaways Express Entry is evolving, not collapsing, and many core features remain stable for now. Ministerial instruction changes could happen quickly and may affect CRS scoring factors. Regulatory reforms, including a potential merger of FSW, CEC, and FST, are expected later. Applicants should assess whether their occupation, Canadian experience, education, spouse, French, PNP, or job offer strategy may be affected. Quotes from the Episode: Mark Holthe: “Change is here. It is right on the doorstep.” Alicia Backman-Beharry: “It's so helpful to understand which reforms are coming and when they're coming.” Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Show #1154 The Real Thing 01. John Primer & Friends - We All Need Help (3:46) (Tribute To Theresa's Lounge, Blues House Productions, 2026) 02. Billy Thompson - Truth Come To Power (4:45) (This World, MoMojo Records, 2026) 03. Matthew Patrick - Hi Flyer (3:23) (Red River EP, self-release, 2026) 04. Dave Thomas - Big Fast Car (2:47) (Bridge Street Blues, Blonde On Blonde Records, 2026) 05. Sherri Harding - What's The Matter (With My Heart) (3:05) (Storyland, Instant Replay Music, 2026) 06. Cary Morin - It Matters To You Now (6:13) (Songs From Anguilla 2026 EP, Maple Street Music, 2026) 07. Billy Price - Exit Strategy (4:03) (Random Madness, Get Hip Records, 2026) 08. Geiger von Müller - After The Slide (0:55) (Neocubist Blues, self-release, 2026) 09. Nicky T & the Snake Charmers - Ain't Wasting Time (10:15) (Ain't Wasting Time, self-release, 2026) 10. Satori - Tease Blues (3:34) (The Seat Of The Soul, Klopotec Records, 2026) 11. Duke Robillard & his All Star Band - Feel My Cares (4:44) (Blast Off!, Nola Blue Records, 2026) 12. Steve Marriner - Hellbound For Heaven (3:49) (Hear My Heart, Cordova Bay Records, 2025) 13. The Shaelyn Band - I Won't Sell My Soul (4:12) (Chapter 3, House Of Berry Records, 2026) 14. Chris Bergson - Little Girl Blue (6:21) (East River Blues, CRS/2 Shirts Records, 2026) 15. Carmen Ratti Band (ft. Jill Dineen) - I Can See (3:52) (Come To Me, MoMojo Records, 2026) 16. Jump 66 - Straight From The Bottle (5:00) (Every Dog Has Its Day, self-release, 2026) 17. Royal & Toulouse - I See One Thing (5:53) (Tell The Devil, Little Town Sound, 2025) 18. Jason Ricci & the Bad Kind - Sick Of This Shit (8:30) (13 Hours, Gulf Coast Records, 2026) 19. ElectroBluesSociety - Be Alright (5:04) (Bluestronica Midnight Sessions, Black & Tan Records, 2026) Bandana Blues is and will always be a labor of love. Please help Spinner deal with the costs of hosting & bandwidth. Visit www.bandanablues.com and hit the tipjar. Any amount is much appreciated, no matter how small. Thank you.

Tracklist: https://www.bestdrumandbass.com/podcast597/This week is extra special: Tom Finster has a new self released album dropping, and as you will soon see, it is full of amazingly lush and wonderful tunes. We are also celebrating the latest release on Abducted LTD in the resident seat, so lock it in, and lets rock it out!Direct Shift ft Sez'Nah - D.Y.C.A.G.Y.S / Bankruptcy [Abducted LTD]Download / Stream: bestdrumandbass.com/altd141/Supported by: MNDSCP, Manta, X.morph, Doc Scott, Akrom, Pish Posh, Stonx, MV, Direct Shift, Unknown Konflikt, Contam, Protoss, Bytecode, Acidion, MYGR, Jane Doe DNB, SeanTron, ESKR, Nox, Insom, Confusion, Subconscious BSC, Needlenose, Hijk, Tschul, Korax, CRS, ARI-ON, Metric, Figure, Quannum Logic, Sindicate, Crackindomes, RCA Trash, J. Augustus, Jay, Lennart Hoffmann, Johannes Soppa, Octane Amy, Ollie Duracell, Dan, Murmuration Events, Lee UHF, BassDrive.com, Sinuous Recordings and moreSubscribe to the podcast: bestdnb.com/podcast

Dr. Shuvro Roy and Dr. Amanda Piquet discuss a brief overview of stiff person syndrome, as well as the trial and the trial results.  Read more about this abstract on the AAN website.   Show transcript:  Dr. Shuvro Roy: Hi, this is Shuvro Roy from the University of Washington and welcome to today's Neurology Minute. I just wrapped a longer conversation with Amanda Piquet from the University of Colorado Anschutz School of Medicine. We were just talking about the recent Phase 2 trial evaluating Miv-cel Kyverna Therapeutics' anti-CD19 CAR T-cell therapy in patients with Stiff Person Syndrome. Amanda, would you mind taking us through a brief overview of SPS as well as the trial and their trial results? Dr. Amanda Piquet: So Stiff Person Syndrome, or SPS, is a rare disabling autoimmune neurologic disease with a major unmet need. About 80% of patients ultimately lose their mobility and we currently have no FDA approved therapies. Existing treatments like IVIG, rituximab, and plasmapheresis are all used off label, often requiring chronic dosing and frequently failing to stop progression. KYSA-8 is a registrational Phase 2 study of 26 patients with refractory SPS. Patients experienced rapid, statistically significant and clinically meaningful improvement across all primary and secondary endpoints. Primary endpoint was the timed 25-foot walk. And this improved by a median of 46% at 16 weeks. Of patients requiring walking aids at baseline, about two thirds no longer needed them by week 16 to complete that 25-foot walk. Some patients who had struggled to walk were even able to run again after treatment. Another key finding was that all patients discontinued chronic immune therapies and remained off treatment as of the last follow-up. From a safety standpoint, miv-cel was generally well tolerated, with no high grade CRS or ICANS observed. In my opinion, these outcomes are unlike anything we've seen previously with Stiff Person Syndrome and may represent a paradigm shift, not only for SPS, but potentially for other antibody-mediated neurologic diseases more broadly. Dr. Shuvro Roy: Just curious, are there any upcoming implications for the application of this treatment for patients, you think, in the coming year or so? Dr. Amanda Piquet: Kyverna, the company who developed miv-cel, has initiated a rolling BLA with the FDA for potential approval and this would be, if approved, the first CAR-T therapy for SPS. So we're anxiously awaiting the outcome of that process. Dr. Shuvro Roy: Fantastic. Amanda, thank you so much for your time. And if you are intrigued and want to know more details behind the findings in the study as well as a conversation around CAR-T therapy for autoimmune neurologic disease as a whole, I encourage you to check out the Neurology Podcast feed for our full conversation there. Thanks for tuning in.  

Dr. Shuvro Roy and Dr. Amanda Piquet discuss a brief overview of stiff person syndrome, as well as the trial and the trial results.  Read more about this abstract on the AAN website.   Show transcript:  Dr. Shuvro Roy: Hi, this is Shuvro Roy from the University of Washington and welcome to today's Neurology Minute. I just wrapped a longer conversation with Amanda Piquet from the University of Colorado Anschutz School of Medicine. We were just talking about the recent Phase 2 trial evaluating Miv-cel Kyverna Therapeutics' anti-CD19 CAR T-cell therapy in patients with Stiff Person Syndrome. Amanda, would you mind taking us through a brief overview of SPS as well as the trial and their trial results? Dr. Amanda Piquet: So Stiff Person Syndrome, or SPS, is a rare disabling autoimmune neurologic disease with a major unmet need. About 80% of patients ultimately lose their mobility and we currently have no FDA approved therapies. Existing treatments like IVIG, rituximab, and plasmapheresis are all used off label, often requiring chronic dosing and frequently failing to stop progression. KYSA-8 is a registrational Phase 2 study of 26 patients with refractory SPS. Patients experienced rapid, statistically significant and clinically meaningful improvement across all primary and secondary endpoints. Primary endpoint was the timed 25-foot walk. And this improved by a median of 46% at 16 weeks. Of patients requiring walking aids at baseline, about two thirds no longer needed them by week 16 to complete that 25-foot walk. Some patients who had struggled to walk were even able to run again after treatment. Another key finding was that all patients discontinued chronic immune therapies and remained off treatment as of the last follow-up. From a safety standpoint, miv-cel was generally well tolerated, with no high grade CRS or ICANS observed. In my opinion, these outcomes are unlike anything we've seen previously with Stiff Person Syndrome and may represent a paradigm shift, not only for SPS, but potentially for other antibody-mediated neurologic diseases more broadly. Dr. Shuvro Roy: Just curious, are there any upcoming implications for the application of this treatment for patients, you think, in the coming year or so? Dr. Amanda Piquet: Kyverna, the company who developed miv-cel, has initiated a rolling BLA with the FDA for potential approval and this would be, if approved, the first CAR-T therapy for SPS. So we're anxiously awaiting the outcome of that process. Dr. Shuvro Roy: Fantastic. Amanda, thank you so much for your time. And if you are intrigued and want to know more details behind the findings in the study as well as a conversation around CAR-T therapy for autoimmune neurologic disease as a whole, I encourage you to check out the Neurology Podcast feed for our full conversation there. Thanks for tuning in.  

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry continue their series on major Express Entry reforms expected in Canada. They examine IRCC's own data on Express Entry outcomes, why Canada is still proposing major reforms to a system that appears to be working, and how high wages, job offers, Canadian experience, French language ability, category-based draws, and immigration levels could reshape future permanent residence strategies. Key Topics Discussed IRCC data on Express Entry outcomes High-wage Canadian work experience and job offers Immigration levels and temporary resident reductions Why Express Entry reforms are being proposed Key Takeaways Express Entry applicants generally have strong employment, wage, and occupation-match outcomes. IRCC appears to be recalibrating the system toward high-wage earners and stronger economic predictors. Reduced temporary resident and permanent resident targets are making PR planning more competitive. Applicants should reassess CRS strategies that rely on bonus points, occupation categories, French, Canadian education, and timing. Quotes from the Episode: Mark Holthe: “Does my current CRS strategy, the factors I'm counting on, the timing I've planned, the profile I've built still make sense under a system being recalibrated toward high-wage earnings?” Alicia Backman-Beharry: “They are changing things not because they don't work, not because they're broken, but because they want to make it better.” Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Episode Summary: In this episode, Mark Holthe and Alicia Backman-Beharry launch a new series on major Express Entry reforms expected in Canada. They explain how Express Entry works, why it is not a permanent residence program itself, what applicants need to understand about the current system, and how upcoming changes to CRS points, category-based draws, and program structures could affect future permanent residence strategies. Key Topics Discussed Express Entry basics Federal Skilled Worker, Canadian Experience Class, and Federal Skilled Trades CRS score factors Upcoming Express Entry reforms Key Takeaways Express Entry is a system for managing economic immigration applications, not a program itself. Being in the Express Entry pool does not guarantee an invitation to apply. Canadian Experience Class and category-based draws are currently playing a major role. Upcoming reforms could significantly change how CRS points are awarded. Quotes from the Episode: Mark Holthe: “There's nothing more important than knowing what's coming and then doing what you can to increase your chances of success.” Alicia Backman-Beharry: “What people do right now is going to impact whether their profile is one that has a chance in the future.” Links and Resources Watch this episode on YouTube Canadian Immigration Podcast Book a consult Enroll in the Express Entry Accelerator and Masterclass Subscribe for MoreStay up-to-date with the latest in Canadian immigration by subscribing to the Canadian Immigration Podcast on iTunes, Spotify, or YouTube. Don't miss future episodes on policy changes, strategies, and practical advice for navigating Canada's immigration process. Disclaimer This episode provides general information about Canadian immigration and is not intended as legal advice. For personalized assistance, consult an immigration lawyer.

Tracklist and more info: https://www.bestdrumandbass.com/podcast596/Happy Friday my friends! We have a VERY SPECIAL edition this week, as one of the long time Abducted artists BINARY are here for a guest mix to celebrate their epic release on Skamele! Lock it in, and be ready to rock out my friends. The weekend has begun! The In Kill - Go Forth / Sick [Abducted LTD]Download / Stream: bestdrumandbass.com/altd140/Supported by: Doc Scott, Stonx, Akrom, Bad Syntax, 5AH5H, Direct Shift, Bytecode, Protoss, Acidion, Contam, Neothrope, Oalky, ESKR, Figure, DJ Odi, ARI-ON, Hijk, Metric, Quannum Logic, Malasuerte, Nox, Subcat, Korax, CRS, SeanTron, Autopsy, RCA Trash, J. Augustus, Sinuous Recordings, Tschul, Reverend Kathy Russell, John Morgan, Inside Dnb, Chris, Jay, Johannes Soppa, Lennart Hoffmann, Subconscious BSC, Critical Control Point, Crackindomes, Octane Amy, Confusion and more!Subscribe to the podcast: bestdnb.com/podcast

Full episode info here: https://www.bestdrumandbass.com/podcast595/#NEUROWEIRDO is here yet again, and we are back and a pocket full of streaming troubles couldnt stop us! In the guest mix this week we have the ATL homie DEMOTANK slaying, and in the resident mix we are pushing the massive new single by THE IN KILL! Lock it in, its time to rock it out! The In Kill - Go Forth / Sick [Abducted LTD]Download / Stream: bestdrumandbass.com/altd140/Supported by: Doc Scott, Stonx, Akrom, Bad Syntax, 5AH5H, Direct Shift, Bytecode, Protoss, Acidion, Contam, Neothrope, Oalky, ESKR, Figure, DJ Odi, ARI-ON, Hijk, Metric, Quannum Logic, Malasuerte, Nox, Subcat, Korax, CRS, SeanTron, Autopsy, RCA Trash, J. Augustus, Sinuous Recordings, Tschul, Reverend Kathy Russell, John Morgan, Inside Dnb, Chris, Jay, Johannes Soppa, Lennart Hoffmann, Subconscious BSC, Critical Control Point, Crackindomes, Octane Amy, Confusion and more!Subscribe to the podcast: bestdnb.com/podcast

Beau Welling joins CRS to talk about whether the current golf course renovation boom is warranted or driven by FOMO,  and how land planning fits into his design business. He also discusses designing the green and virtual holes for TGL, what golf can learn from curling, and gives updates on major projects at Kiawah and Lake Oconee.

Tracklist and more info: https://www.bestdrumandbass.com/podcast593/Welcome back my friends, we have another wicked week in store for you! HIJK is here to present a wicked mix in the guest spot, and as always we have BAd Syntax kicking things off. So lock it in, and lets rock it out! Subscribe to the podcast: bestdnb.com/podcast  KORAX - Scorched Planet / Dropship [Abducted LTD]Download / Stream: bestdrumandbass.com/altd139/Supported by: Doc Scott, Pish Posh, Akrom, Stonx, 5HA5H, Bad Ace, Quannum Logic, Sinuous Recordings, MYGR, Korax, ESKR, Manta, Contam, Nox, Diode, Acidion, Unknown Konflikt, Malasuerte, CRS, X.morph, Sindicate, GroVe, Subcat, Protoss, Bytecode, Plasmator, ARI-ON, Crackindomes, Affirmation, Tschul, Autopsy, Ollie Duracell, RCA Trash, Confusion, Critical Control Point, Octane Amy, BassDrive.com, Lee UHF, Inside Dnb, Lennart Hoffmann, Johannes Soppa, Knoxz, MV, Metric, J. Augustus and more! 

Tracklist and more info: https://www.bestdrumandbass.com/podcast592/We are back for another BANGER of a session this week my friends! We have MOFW with his debut on the podcast bringing the heavier side of DNB, and you have the usual resident mix with Bad syntax to get things shaking. Lock it in, and lets rock it out. The weekend has begun! Subscribe to the podcast: bestdnb.com/podcast  KORAX - Scorched Planet / Dropship [Abducted LTD]Download / Stream: bestdrumandbass.com/altd139/Supported by: Doc Scott, Pish Posh, Akrom, Stonx, 5HA5H, Bad Ace, Quannum Logic, Sinuous Recordings, MYGR, Korax, ESKR, Manta, Contam, Nox, Diode, Acidion, Unknown Konflikt, Malasuerte, CRS, X.morph, Sindicate, GroVe, Subcat, Protoss, Bytecode, Plasmator, ARI-ON, Crackindomes, Affirmation, Tschul, Autopsy, Ollie Duracell, RCA Trash, Confusion, Critical Control Point, Octane Amy, BassDrive.com, Lee UHF, Inside Dnb, Lennart Hoffmann, Johannes Soppa, Knoxz, MV, Metric, J. Augustus and more!