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Lauren and JJ welcome veterinary neurologist Dr. Jill Narak to the podcast to discuss brain-eating and brain-hijacking (zombie!) diseases. Resources: * IMDB entry for The Return of the Living Dead (1985), directed by Dan O'Bannon: https://www.imdb.com/title/tt0089907/ * Behavior-altering parasites, Wikipedia, accessed 10/26/24: https://en.m.wikipedia.org/wiki/Behavior-alteringparasite * Naegleria fowleri infection, Centers for Disease Control, accessed 10/26/24: https://www.cdc.gov/naegleria/about/index.html * Transmissible spongiform encephalopathies, National Institute of Neurological Disorders and Stroke, accessed 10/26/24: https://www.cdc.gov/naegleria/about/index.html * Echinococcosis, Centers for Disease Control, accessed 10/26/24: https://www.cdc.gov/naegleria/about/index.html * Siyadatpanah, A., et al. Cerebral cystic echinococcosis (2020). Case reports in infectious diseases. https://pmc.ncbi.nlm.nih.gov/articles/PMC7066420/ * Heyward, G. The zombie fungus from 'The Last of Us' is real - but not nearly as deadly (2023), NPR, last accessed 10/26/24: https://www.npr.org/2023/01/30/1151868673/the-last-of-us-cordyceps-zombie-fungus-real# * Flegr, J. Effects of _Toxoplasma on human behavior (2007). Schizophrenia bulletin, 33(3): 757-760. https://pmc.ncbi.nlm.nih.gov/articles/PMC2526142/ * Adebiyi, O. E., et al. Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wister rats (2021). Heliyon, 7(11). https://pmc.ncbi.nlm.nih.gov/articles/PMC8571699/ * Alvarado-Esquivel. Toxocara infection in psychiatric inpatients: A case control seroprevalence study (2013). PLoS One, 8(4). https://pmc.ncbi.nlm.nih.gov/articles/PMC3633879/ * Horsehair worm. The Wildlife Trusts, accessed 10/26/24. https://www.wildlifetrusts.org/wildlife-explorer/marine/worms/horsehair-worm# * Gasque, S. N., et al. Where the baculoviruses lead, the caterpillars follow: baculovirus-induced alterations in caterpillar behavior (2019). Current opinion in insect science, 33: 30-36. https://www.sciencedirect.com/science/article/abs/pii/S2214574518300841# * Clinical Overview of Rabies, Centers for Disease Control, accessed 10/26/24: https://www.cdc.gov/rabies/hcp/clinical-overview/index.html * Zombie, Wikipedia, accessed 10/26/24: https://en.wikipedia.org/wiki/Zombie Special Guest: Jill Narak.
In this Vet Times Podcast, sponsored by Boehringer Ingelheim Animal Health, Eric Morgan, professor of veterinary parasitology at Queen's University Belfast, discusses the prevalence of Toxocara in the environment and why vets should care. Toxocara is a zoonotic parasite endemic throughout the UK and Ireland and has been associated with multiple human health conditions including asthma and reduced cognitive function. Eric, a recognised specialist in parasitology, brings insights from his research into parasites, especially helminths, to advise what can be done, such as the importance of monthly worming, to reduce the risk of Toxocara spread and infection. The podcast is part of Boehringer Ingelheim's support for vets to improve health and well-being of pets and pet owners through their range of medicines. •••
Joining Anthony for today's episode of VETchat is Ian Wright, Veterinary Surgeon and Parasitologist at the Mount Veterinary Practice, Fleetwood. In this episode, Anthony and Ian discuss a whole lot of parasitology! They talk about Animal Health Certificates; what they are, what is needed for them, and their benefits and drawbacks. Anthony asks Ian for his opinion on the government removing the compulsory treatment of ticks when animals travel and the dangers of bringing parasites over from other countries. Ian shares information on parasites including Rhipicephalus, Leishmania, Toxocara, and the risk that Phortica Variegata may bring to the UK. They discuss whether we are still over-treating animals and whether Ian thinks we should be doing more surveillance such as flea comings and faecal egg counts.
Dickson, Daniel and Vincent solve the case of the Middle Aged Woman with Loss of Vision in One Eye, and discuss the role of heme oxygenase in the various protozoan infections. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Heme oxygenase-1 in protozoan infections (PLoS Path) Support Floating Doctors at PWB Letters read on TWiP 187 Become a patron of TWiP Case Study for TWiP 187 Pregnant newly married, living North Shore, first pregnancy. Affluent family, measured successful lawyer who cooks. Organic eating. Boy born at 9 mo, has midwife, has delivery at home. Baby has enlarged head. OB diagnosed with hydrocephalus. Mother healthy. No meds. Works in retail store, lives with husband, not working for second half of pregnancy. Drank alcohol rarely. No significant travel. Patient reports having no pets but her brother owns small farm, and husband likes serving rare meats, all kinds, which she has eaten since she married him. Will do ultrasound, CT, blood work. Music by Ronald Jenkees
Lauren and JJ discuss a dog presenting with weight loss. Is the answer in the trash bag full of poo? In this episode, the ladies discuss differentials for weight loss in a senior mixed breed dog and eventually arrive at a diagnosis of whipworms. There’s a deep dive into all things Trichuris vulpis, including types of fecal parasite testing, the whipworm life cycle, and treatment options. The ladies also reminisce about 1996, debate the taste of various dewormers, and share an embarrassing story or two. Sources for this episode include: 1. “Trichuris Vulpis.” capcvet.org. Companion Animal Parasite Council, October 1, 2016. https://capcvet.org/guidelines/trichuris-vulpis/ 2. Rothrock, Kari and Linda G. Shell. “Vincyclopedia of Diseases: Trichuriasis/Whipworms.” vin.com. Veterinary Information Network, September 5, 2019. 3. Vincent-Johnson, Nancy. “Contamination with Toxocara spp from Dog Walking.” cliniciansbrief.com. Clinician’s Brief, April 2019. https://www.cliniciansbrief.com/article/contamination-toxocara-spp-dog-walking
Bugs are Coming! Safe Products for Breeding Dogs + CoronavirusDr. Marty Greer brings her pragmatic Veterinary Voice to the topic of Coronavirus and what products are safe to use for flea, tick and heartworm prevention in breeding dogs. COVID-19 is not currently believed to be communicable between humans and dogs. Coronavirus is a general term for a *shape* of a virus and encompasses a variety of viral infections in many species. For more information on recommendations regarding veterinary care during this outbreak, click https://www.foxrothschild.com/publications/coronavirus-response-plans-for-veterinary-practices/ (here). As spring brings the reemergence of various creepy, crawly parasites that affect our dogs, Greer provides in-depth information about which products are safe for use on dogs in our breeding programs, including brood bitches and stud dogs over the course of time, as well as bitches in whelp. Greer said, “I think it's really appropriate for us to stick to the EPA and FDA approved drugs that we know have been tested and safe in breeding animals. So, for instance, Bravecto says there were no clinically relevant treatment-related effects on body weights, food consumption, reproductive performance, semen analysis, litter data, gross necropsy or Histology findings in adults and puppies. So we need to be looking for that kind of language on a label before we go slapping things on or popping things into our dogs … I just want to be perfectly clear for what products have or have not been tested. "So there's three basic categories of flea and tick medications. There's the collar, there's the topical, the oil that goes over the back of the neck or down the back and there's the tablets or the chewables. So there are the three general categories and of those three there's no collar …. labeled for that use in breeding dogs … the topicals, some are definitely labeled and some are not definitely labeled. …if it says like Frontline says safe for breeding, pregnant and lactating dogs and cats, then it's safe. If it doesn't say that you shouldn't use it. It needs to be clear. And if we look at the oral there's …. three oral medications that are not labeled for use in breeding animals. Bravecto is labeled for use in breeding animals. So we need to be really, really clear that we're looking at the labels or reading the instructions and we're thinking at eight weeks of age, what is the this dog’s future, not just is she pregnant right now, but what is her future.” Product Active Ingredients Purpose/Effective Against Minimum Age/Weight Pregnant/Nursing/Male Heartworm Advantage Multi for Dogs Imidacloprid and moxidectin Flea, louse, heartworm, hookworm, whipworm, roundworm and mange. Topical every 30 days 7 weeks/3lbs Safety not established. Advantage Multi for Cats Imidacloprid and moxidectin Ear mites, flea, heartworm, hookworm and roundworm. Topical every 30 days 9 weeks/2 lbs Safety not established. Heartgard Plus Ivermectin,Pyrantel pamoate Heartworm, roundworms & hookworms Tablet every 30 days 6 weeks Safe in pregnant or breeding bitches, stud dogs Heartgard Ivermectin Dog: Heartworm. Tablet every 30 daysCat: Heartworm and hookworm. Tablet every 30 days 6 weeks Safe Interceptor Milbemycin oxime Heartworm, hookworm, whipworm, roundworm. Every 30 days Dog: 4 weeks/2 lbsCat: 6 weeks/1.5lbs Dogs: SafeCat: Not established Interceptor Plus Milbemycin oxime and praziquantel tablet Heartworm, roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) Tablet every 30 days Dogs and puppies 2 pounds of body weight or greater and 6 weeks of age and older. SafeNot evaluated in breeding, pregnant or lactating dogs. Only milbemycin has been studied and is safe. Iverhart Max Ivermectin,Pyrantel pamoate,... Support this podcast
The TWiPlicates solve the case of the Child With Retinal Granuloma, and discuss an association of the complement protein collectin-11 with the pathophysiology of Chagas disease. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Chagas disease pathophysiology and collectin-11 (PLoS NTD) Hero: Theobald Smith Image credit: Toxocara canis by Ben Liffner Letters read on TWiP 170 Case Study for TWiP 170 3 yo girl, same context: mobile clinic in Bocas del Toro archipelago. Small village on remote island. Initially had red eye, rubbing a lot, mother noticed she seemed to have vision loss. On exam ophthalmologist did fundoscopic exam, sees band keratopathy, calcium on the cornea, and outer retinal punctate lesions. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
The CDC reports--A U.S. study in 1996 showed that 30% of dogs younger than 6 months deposit Toxocara eggs in their feces; other studies have shown that almost all puppies are born already infected with Toxocara canis. Research also suggests that 25% of all cats are infected with Toxocara cati. In humans, it has been found that almost 14% of the U.S. population has been infected with Toxocara. Globally, toxocariasis is found in many countries, and prevalence rates can reach as high as 40% or more in parts of the world. What is toxocariasis and what is the situation in the United Kingdom? Veterinary surgeon and parasitologist, Dr Ian Wright joined me to look at this nematode, the situation is the UK and prevention measures.
The CDC reports–A U.S. study in 1996 showed that 30% of dogs younger than 6 months deposit Toxocara eggs in their feces; other studies have shown that almost all puppies are born already infected with Toxocara canis. Research also suggests that 25% of all cats are infected with Toxocara cati. In humans, it has been […] The post Toxocara in the UK: A discussion with Dr Ian Wright appeared first on Outbreak News Today.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 18/19
In der vorliegenden Arbeit wurden insgesamt 497 Patienten mit mikroskopisch gesicherten Helminthiasen hinsichtlich epidemiologischer und klinischer Daten sowie auf indirekte Laborparameter (Eosinophilie und Gesamt-IgE-Erhöhung) und die Resultate immundiagnostischer Verfahren untersucht. Hierbei wurden die Ergebnisse von 329 Reiserückkehrern und 168 Migranten mit jeweils 8 Diagnosen (Ankylostomiasis, Askariasis, Fasziolose, Filariose, Schistosomiasis, Trichinose, Trichuriasis, Mischinfektionen) miteinander verglichen. Für die Evaluation der immundiagnostischen Verfahren wurden vorhandene Seren mit 9 Antigenen (Schistosoma mansoni, Onchocerca volvulus, Dirofilaria imitis, Trichinella spiralis, Fasciola hepatica, Toxocara canis, Strongyloides ratti, Ascaris lumbricoides, Ascaris suum) getestet. Vorbestehende Ergebnisse aus der Routinediagnostik wurden mit einbezogen. Als Kontrollen dienten die Seren von 80 gesunden Personen ohne Hinweise auf eine Wurmerkrankung in der Vorgeschichte und ohne einen vorherigen Aufenthalt in den Tropen oder Subtropen. Die epidemiologischen Daten zeigen eine eindeutige Zuordnung von Schistosomiasis und Filariosen auf den afrikanischen Kontinent, während die Geohelminthiasen (Erkrankungen durch Helminthen, deren präadulte Stadien sich im Erdboden entwickeln und die eine reise- bzw. migationsmedizinisch wichtige Bedeutung haben) von den Reiserückkehrern vorwiegend in Asien, vorzugsweise in Südostasien, akquiriert wurden. Die Migranten stammten hauptanteilig aus Afrika, es waren dennoch alle wesentlichen tropischen und subtropischen Gebiete vertreten. Die Auswertung der klinischen Symptomatik zeigte ein klares Erscheinungsbild der Filariosen mit Hauterscheinungen und Juckreiz sowie die überdurchschnittlich häufige Angabe von Harnwegsbeschwerden bei Infektionen mit Schistosoma haematobium. Bei allen Geohelminthosen und Infektionen mit Schistosoma mansoni herrschte bei den Reiserückkehrern eine gastrointestinale Symptomatik vor, während die Migranten insgesamt mehr unspezifische Beschwerden aufwiesen. Circa ein Drittel der Patienten war asymptomatisch. Die Sensitivität der Eosinophilie als indirekter Parameter lag in dieser Arbeit für Wurmerkrankungen im Allgemeinen bei 45%, variierte aber von Diagnose zu Diagnose erheblich, wobei kein signifikanter Unterschied zwischen Reiserückkehrern und Migranten zu finden war. Eine Hypereosinophilie fand sich überdurchschnittlich häufig bei Migranten mit Filariose und bei Reiserückkehrern mit Strongyloidiasis; die Patienten mit Askariasis und Trichuriasis zeigten dagegen kaum Abweichungen von der Kontrollgruppe. Eine Gesamt-IgE-Erhöhung fand sich insgesamt bei 43% der Patienten, wobei es einen signifikanten Unterschied zwischen Reiserückkehrern (25%) und Migranten (75%) gab. Besonders hohe IgE-Serumspiegel konnten bei Migranten mit Schistosomiasis, Strongyloidiasis und Ankylostomiasis gefunden werden. Davon abweichend waren allerdings die Resultate von Reiserückkehrern mit Mischinfektionen. Bei diesen Patienten konnte eine unerwartet häufige Gesamt-IgE-Erhöhung verzeichnet werden (75%). Die serologischen Untersuchungen zeigten zumeist eine gute Sensitivität, aber erhebliche Kreuzreaktionen mit verwandten und nicht verwandten Wurmarten, sodass eine Differenzierung nur für die Schistosomiasis und die Filariosen valide gewährleistet ist. Der im Rahmen dieser Arbeit entwickelte Ascaris suum-ELISA, ergab eine Sensitivität von 60% und eine Spezifität von 90% und hat in der Routinediagnostik eine gewisse Berechtigung, da der Ascaris lumbricoides-ELISA inakzeptable Ergebnisse erbrachte. Zusammengefasst stellt die Eosinophilie einen wichtigen hinweisenden Parameter auf eine Wurminfektion dar, ist aber keine ausreichende Screeningmethode bei Rückkehr aus Endemiegebieten. Die serologischen Untersuchungen ergaben eine sinnvolle diagnostische Ergänzung bei der Schistosomiasis und den Filariosen. Eine Differenzierung der Geohelminthosen ist weiterhin nur durch direkte Nachweismethoden, wie z. B. dem Ei- bzw. Larvennachweis im Stuhl oder in einem Körpergewebe, verlässlich möglich.
From worms to fleas and even microscopic single celled organisms, our pets can transfer a world of parasites to us if we are not careful. Prof Susan Little, a Veternary Parasitologist tells us what parasites we might catch and how we might prevent them. Like this podcast? Please help us by supporting the Naked Scientists
Toxocara, Shotgun Therapy, Noneuclid, Dept-C, Must Missa, At the Throne of Judgment... much more!