Podcasts about Leishmania

Joining Anthony for this episode of VETchat by The Webinar Vet is Ian Wright, chairman of The European Scientific Counsel Companion Animal Parasites (ESCCAP) and practicing vet. In this episode, Anthony and Ian discuss the evolving landscape of veterinary practice, particularly in relation to the increasing prevalence of exotic parasites in the UK. They talk about the impact of pet travel, climate change, and the rise of diseases like Leishmania and tick-borne illnesses. Ian emphasises the importance of vigilance and adaptability in veterinary practice to manage these emerging challenges effectively.

TWiP solves the case of the woman who went to Belize and notices a lesion on her face, and presents a new clinical case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 251 New Case Recent case, Arusha hospital, 1800 m, 28 yo comes in, has been visiting game parks. Developing fevers, malaise, bad headaches, body aches, somnolent. Blood smears negative, no malaria. Repeat blood smear, see something extra-erythrocytic. This gives them the diagnosis. HIV neg, no toxic habits, no history. Symptom onset about a week ago. Rest of family is ok.  Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Pesquisadores das universidades Federal de São Carlos (UFSCar), Estadual de Campinas (Unicamp) e de São Paulo (USP) caracterizaram, pela primeira vez, uma classe de proteínas do parasita Leishmania infantum envolvida na regulação de seu ciclo celular.

Unleashed: The Dawn of the Leishmania Intro Chapter 1: The Attack of the Sandfly 3.17 Sue introduces the topic of leishmaniasis, and Christian describes leishmaniasis as a multisystemic disease affecting humans and animals, primarily dogs. He notes its prevalence in regions like the Mediterranean and its expansion due to climate change and imported infected dogs. 5.19 Sue questions whether leishmaniasis occurs naturally in the UK or is solely imported. Christian mentions reported cases in the UK, suggesting transmission via infected phlebotomine flies brought back by travelers from endemic regions. The conversation shifts to the sandfly vector responsible for transmitting leishmaniasis. Christian describes the sandfly as small, silent, and potentially painless, emphasizing its absence in the UK but the possibility of migration due to global warming. Christian advises against using repellents on dogs in the UK due to environmental concerns but stresses the importance of monitoring the situation, given he acknowledges the likelihood of sandflies reaching the UK in the future. 7.27 John queries if leishmaniasis can be transmitted by other vectors like fleas. Christian affirms that sandflies are the primary vector for the disease, although other potential vectors are suspected but not proven. John then asks if humans can contract the disease from infected dogs. Christian explains that with the vector absent in the UK, human transmission from dogs is unlikely. However, he emphasizes the importance of isolating positive dogs to prevent transmission through blood transfusion. Chapter 2: The Haunting Symptoms and Diagnosis 9.11 The conversation then transitions to the clinical signs of leishmaniasis. Christian describes typical systemic symptoms such as anorexia, weight loss, lethargy, and mucous membrane pallor, along with some less common signs like polyuria and polydipsia. Christian also discusses characteristic skin lesions, including non-pruritic exfoliative dermatitis and erosive lesions. Sue adds her observations about the scaly appearance of affected dogs without itchiness, contrasting it with parasitic skin conditions. Christian concludes by stressing the importance of diagnostic assistance in accurately identifying the disease, especially considering its varied clinical presentations. 12.09 Sue brings up how leishmaniasis can affect nails, prompting Christian to elaborate on what clinicians might observe. He describes nails that grow unusually long and fast, resembling talons rather than being deformed. Christian notes that this sign is relatively rare in his experience, with scaly dermatitis or ulcerative dermatitis being more common presentations. 13.11 Sue then queries whether certain clinical presentations carry a better prognosis than others. Christian explains that prognosis depends on the severity of internal organ involvement, particularly kidney disease. The disease originates from the skin but can affect various body parts due to the immune system's reaction. 14.12 John asks how general clinicians diagnose it. Christian outlines that diagnosis relies on compatible clinical signs and specific clinical pathologies, notably anemia and changes in protein levels. While general practitioners can conduct serological tests, more specialized examinations may require referral to a laboratory. Christian emphasizes the importance of considering travel history and ruling out other conditions before treatment initiation. 16.40 Sue raises the issue of screening for leishmaniasis in dogs rescued from abroad, inquiring about the incubation period and when to start screening. Christian explains that the incubation period varies greatly, suggesting performing a quantitative serological test six months after returning from an endemic area. If positive, measures like using repellent and excluding the dog from blood transfusion banks are advised. Sue seeks more detail on the blood tests, and Christian elaborates on measuring the amount of Leishmania-specific antibodies using quantitative serological tests. These tests help detect high antibody levels, indicative of infection. Advert Ditty What products do we have now? Do we have a Zincoseb one, any shampoos? Chapter 3: Eternal Vigilance Against the Parasite 18.55 John then asks about therapy options for positive cases. Christian emphasizes the goal of controlling clinical signs and pathological abnormalities, as complete parasite elimination is rare. Therapy typically involves a combination of leishmanicidal drugs, which aim to kill the parasite, and leishmaniostatic drugs, which maintain a low parasitic level, together aiming to reduce the parasitic load and prevent relapses. He notes the need for topical treatments alongside systemic therapy to manage symptoms like scaly skin. 22.00 John asks about drug availability and Christian mentions challenges in drug availability and potential side effects, particularly with drugs like allopurinol, which can cause adverse urinary effects. He recommends monitoring for crystal formation in the urine and considering alternative treatments if needed, highlighting emerging immunomodulatory drugs as promising options. However, his leishmanicidal drugs of choice would be allopurinol and meglumine antimonate. 23.55 Sue then asks about the expected response time to treatment and the monitoring process. Christian explains that clinical improvement can be seen in about four weeks with meglumine antimonate and two months with Miltefosine, an oral drug. Monitoring every three to four months is crucial, although antibody titres may take longer to decrease. 24.55 John asks about the lifelong management of the disease. Christian confirms that the drugs can be expensive and may need to be imported, emphasizing the importance of compliance and regular check-ups to improve prognosis. 25.51 Sue concludes by highlighting the role of primary care vets and dermatologists in managing the disease. She also enquires about alternative treatments like turmeric and herbal concoctions. Christian stresses the importance of evidence-based treatments and mentions dietary nucleotides and active hexose correlated compounds as effective alternatives. 27.29 Sue thanks Christian and expresses concern about the potential spread of leishmaniasis in the UK due to warmer summers and increased animal movements across borders.

Laura Catalán, nuestra veterinaria de referencia, nos habla de la Leishmaniosis y de la Filariasis, dos enfermedades parasitarias muy peligrosas, que pueden desencadenar en graves consecuencias para la salud de nuestras mascotas; y nos da claves para prevenir, detectar y combatir sus efectos.

Nesta edição do "CBN Meio Ambiente e Sustentabilidade", o comentarista Marco Bravo, na série "Mudanças Climáticas X Saúde" traz o alerta com relação aos riscos da leishmaniose e filariose. O que são? A leishmaniose é uma doença infecciosa, porém, não contagiosa, causada por parasitas do gênero Leishmania. Os parasitas vivem e se multiplicam no interior das células que fazem parte do sistema de defesa do indivíduo, chamadas macrófagos. É uma doença de evolução longa, podendo durar alguns meses ou até ultrapassar o período de um ano. Já a Filariose Linfática (Elefantíase) é uma doença parasitária crônica, considerada uma das maiores causas mundiais de incapacidades permanentes ou de longo prazo. É causada pelo verme nematoide Wuchereria Bancrofti e transmitida pela picada do mosquito Culex quiquefasciatus (pernilongo ou muriçoca) infectado com larvas do parasita. As informações são do Ministério da Saúde. Ouça a conversa completa!

Rafael Esteban es nuestro veterinario de cabecera y explica en Fin de Semana los problemas que pueden causar a nuestros peludos... ¡los parásitos!Son el terror de las mascotas y de sus dueños: garrapatas, pulgas o la leishmania... unos parásitos que florecen con fuerza durante la primavera. Rafael Esteban es veterinario con diez años de experiencia y ha dedicado su espacio del sábado a dar las claves para prevenir que estos organismos ataquen a nuestros peludos: "Viven dentro o fuera de otro organismo al que llamamos huésped. Estos parásitos obtienen beneficios a expensas del propio huésped y le pueden causar un daño o una enfermedad". Parásitos hay de todo tipo: gusanos, trematodos o protozoos como la giardia lamblia: "Es muy frecuente en cachorros que beben de agua contaminada (por ejemplo, en el campo) y produce unas diarreas terribles... y el problema es que se puede transmitir a las personas a través de las heces de nuestros animales" detallaba el experto. Es ahora cuando empieza la campaña de inmunización contra la Leishmania, un protozoo que causa muchos problemas a las mascotas. También las garrapatas que, además, pueden transmitir enfermedades a las personas como la enfermedad de Lyme, provocada por la bacteria Borrelia, que en su peor expresión, puede causar problemas cardíacos o neurológicos.La clave principal para mantener a raya estos parásitos es la prevención:...

Maria Adelaida Gomez joins TWiP to discuss her career and the work of her laboratory on understanding the healing process during cutaneous leishmaniasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Maria Adelaida Gomez Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CIDEIM Healing in cutaneous leishmaniasis (J Immunol) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

  Title of episode: Leishmania in Dogs and Cats Category: Immune System, Parasitology, Zoonotic Disease   Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, VTS SAIM as we talk about: Leishmaniosis in Dogs and Cats! It's a crazy parasite that is zoonotic and not something to mess around with.    Resources We Mentioned in the Show  Parasites - Leishmaniasis from the CDC https://www.cdc.gov/parasites/leishmaniasis/index.html  Leishmaniasis from the World Health Organization https://www.who.int/news-room/fact-sheets/detail/leishmaniasis Leishmaniosis in Dogs from Merck Manual https://www.merckvetmanual.com/generalized-conditions/leishmaniosis/leishmaniosis-in-dogs Leishmaniosis (Visceral Leishmaniasis) in Dogs from Merck Manual https://www.merckvetmanual.com/dog-owners/disorders-affecting-multiple-body-systems-of-dogs/leishmaniosis-visceral-leishmaniasis-in-dogs Canine Leishmaniasis: Update on Epidemiology, Diagnosis, Treatment, and Prevention https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416075/    Don't forget to check out LoveHuvet.com and use our discount code IMFVT10 to receive 10% off your order! Thanks so much for tuning in. Join us again next week for another episode! Want to earn some RACE approved CE credits for listening to the podcast? You can earn between 0.5-1.0  hour of RACE approved CE credit for each podcast episode you listen to.    Join the Internal Medicine For Vet Techs Membership to earn and keep track of your continuing education hours as you get your learn on!   Join now! http://internalmedicineforvettechsmembership.com/   Get Access to the Membership Site for your RACE approved CE certificates Sign up at https://internalmedicineforvettechsmembership.com  Get Access to the Technician Treasure Trove  Sign up at https://imfpp.org/treasuretrove    Thanks for listening!  – Yvonne and Jordan   

Even though Kala-azar is closer to elimination in the country, questions related to how the disease spreads still remain unanswered. Only recently, scientists in India and Bangladesh have understood the dynamics of how Post kala-azar dermal leishmaniasis or PKDL, the skin manifestation of the disease, spreads kala-azar. For the third podcast in the series on kala-azar, Suno India's Menaka Rao speaks to Dr Rahul Chaubey, entomologist at Kala-azar Medical Research Centre, Muzaffarpur to understand the latest in vector research. Reporting for this story was supported by the MSF-DNDi Grant on Neglected Tropical Diseases as part of the Without Borders Media Fellowship. The fellowship encourages independent, impartial and neutral reporting on health and humanitarian crises.  References Transmission Dynamics of Visceral Leishmaniasis in the Indian Subcontinent – A Systematic Literature Review - PMCLivestock and rodents within an endemic focus of Visceral Leishmaniasis are not reservoir hosts for Leishmania donovani | PLOS Neglected Tropical DiseasesEstablishing, Expanding, and Certifying a Closed Colony of Phlebotomus argentipes (Diptera: Psychodidae) for Xenodiagnostic Studies at the Kala Azar Medical Research Center, Muzaffarpur, Bihar, India - PMCOn a Herpetomonas Found in the Gut of the Sandfly, Phlebotomus Argentipes, Fed On Kala-Azar Patients - PMCTen years of kala-azar in west Bengal, Part I. Did post-kala-azar dermal leishmaniasis initiate the outbreak in 24-Parganas? - PMCBionomics of Phlebotomus argentipes in villages in Bihar, India with insights into efficacy of IRS-based control measures | PLOS Neglected Tropical DiseasesSee sunoindia.in/privacy-policy for privacy information.

For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek's disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Ancient chickens and Marek's disease virus (Science) Diversity and dissemination of Leishmania virus and L. braziliensis (Nat Comm) Letters read on TWiV 1074 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Addictive Mandelbrot video and Gore slams COP28 summit Angela – 10 top-trending health questions you had for Dr. Google in 2023 Brianne – Tomato lost in space has been found Kathy – Earthquakes of the 20th Century Vincent – Animator Chris Georgenes especially Tricycle animation study Listener Picks Jason – Spot-on, quick booster explainer and “Inverse” vaccine Slashdot's summary. the full article, primary research article Meika – Iceland earthquake site Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Dr. Michael ginger, Dean of the School of Applied Sciences in the Department of Biological and geographical Science at the University of Huddersfield, in West Yorkshire, England discusses the atypical metabolism and evolutionary cell biology of parasitic and free-living protists, including Leishmania, Naegleria and  even euglinids.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551225v1?rss=1 Authors: Baert, L., Rudy, S., Pellisson, M., Doll, T., Rocchetti, R., Kaiser, M., Mäser, P., Müller, M. Abstract: The parasite Leishmania donovani is one of the species causing visceral leishmaniasis in humans, a deadly infection claiming up to 40,000 lives each year. The current drugs for leishmaniasis treatment have severe drawbacks and there is an urgent need to find new anti-leishmanial compounds. However, the search for drug candidates is complicated by the intracellular lifestyle of Leishmania. Here, we investigate the use of human induced pluripotent stem cell (iPS)-derived macrophages (iMACs) as host cells for L. donovani. iMACs obtained through embryoid body differentiation were infected with L. donovani promastigotes, and high-content imaging techniques were used to optimise the iMACs seeding density and multiplicity of infection, allowing us to reach infection rates up to 70% five days after infection. IC50 values obtained for miltefosine and amphotericin B using the infected iMACs or mouse peritoneal macrophages as host cells were comparable and in agreement with the literature, showing the potential of iMACs as an infection model for drug screening. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.25.550461v1?rss=1 Authors: Paul, R., Chakrabarty, A., Dey, S., Samanta, S., Pandey, R., Maji, S., Pezacki, A. T., Chang, C. J., Datta, R., Gupta, A. Abstract: Copper plays a key role in host-pathogen interaction. We found that during Leishmania major infection, the parasite-harboring macrophage regulates its copper homeostasis pathway in a way to facilitate copper-mediated neutralization of the pathogen. Copper-ATPase ATP7A transports copper to amastigote-harboring phagolysosomes to induce stress on parasites. Leishmania in order to evade the copper stress, utilizes a variety of manipulative measures to lower the host-induced copper stress. It induces deglycosylation and degradation of host-ATP7A and downregulation of copper importer, CTR1 by cysteine oxidation. Additionally, Leishmania induces CTR1 endocytosis that arrests copper uptake. In mouse model of infection, we report an increase in systemic bioavailable copper in infected animals. Heart acts as the major organ for diverting its copper reserves to systemic circulation to fight-off infection by downregulating its CTR1. Our study explores reciprocal mechanism of manipulation of host copper homeostasis pathway by macrophage and Leishmania to gain respective advantages in host-pathogen interaction. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550259v1?rss=1 Authors: Howell, J., Omwenga, S., Jimenez, M., Hammarton, T. C. Abstract: Promastigote Leishmania mexicana have a complex cell division cycle characterised by the ordered replication of several single-copy organelles, a prolonged S phase and very rapid G2 and cytokinesis phases, accompanied by cell cycle stage-associated morphological changes. Here we exploit these morphological changes to develop a high-throughput and semi-automated imaging flow cytometry (IFC) pipeline to analyse the cell cycle of L. mexicana in live cells. Firstly, we demonstrate that, unlike several other DNA stains, Vybrant DyeCycle Orange (DCO) is non-toxic and enables quantitative DNA imaging in live L. mexicana promastigotes. Secondly, by tagging the orphan spindle kinesin, KINF, with mNeonGreen, we describe KINFs cell cycle-dependent expression and localisation. Then, by combining manual gating of DCO DNA intensity profiles with automated masking and morphological measurements of parasite images, visual determination of the number of flagella per cell, and automated masking and analysis of mNG:KINF fluorescence, we provide a newly detailed description of L. mexicana promastigote cell cycle events that, for the first time, includes the durations of individual G2, mitosis and post-mitosis phases. By applying IFC in this way, we were able, in minutes, to capture tens of thousands of high quality brightfield and fluorescent images of live L. mexicana cells in solution, and to acquire quantitative data across multiple parameters for every image captured. Our custom-developed masking and gating scheme, allowed us to identify elusive G2 cells, show that cytokinesis commences during early mitosis and continues after mitosis is complete, and identify newly divided cells that were within the first 12 minutes of the new cell cycle. Our new pipeline offers many advantages over traditional methods of cell cycle analysis such as fluorescence microscopy and flow cytometry and paves the way for novel high-throughput analysis of Leishmania cell division. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode I host a parasite instead of a conventional guest. In the Mexican jungle, deforestation unleashed Leishmania, a parasite vectored by a sandfly, and I am infected. Marked by volcanic lesions on my left cheek and right hand I'm undergoing an impatient transformation(TM), and as I wait for medicine to arrive, I examine my experience through shamanic, ecological, and pragmatic lenses. Relaying the story in classic SPAOP-fashion, I investigate themes of inter-species diplomacy, the thin line between a parasite and a symbiot, between psychedelic ecology and ecodelic psychology, between parasitology and parapsychology, and contemplate the merits of redemption. The Ungoogleable Michaelangelo www.theungoogleable.com IG: void_denizen YT, Twitter, TikTok, etc: https://Linktr.ee/void_denizen Mentioned on the show: -Upstream Color, film by Shane Carruth -The Red Hand Files, newsletter/blog by Nick Cave -Paradise Has Parasites, SPAOP solo pod WAYS TO SUPPORT SPAOP: -get your copy of Impatient Transformations here: www.theungoogleable.com/books -Subscribe -Share -Rate (*****) -Review -patreonize us (http://www.patreon.com/voiddenizen) -donate: Venmo (@voiddenizen) / paypal (snailconvention@gmail.com) Ft. music by Soularflair (https://soularflair.bandcamp.com/) & me (incl. Void Denizen instrumental)

Acompaña a Ricardo Cartas en una emisión más de la revista cultural De eso se trata, espacio de ciencia, de cultura, de gastronomía, de libros y más, de lunes a viernes de 08:30 a 10:00 horas. En Con-ciencia es mejor, el Dr. José Ramón Eguibar, director general de desarrollo internacional, charla acerca del retorno de la úlcera de los chicleros, a propósito del proyecto del tren maya. Esta infección es provocada por una mosca denominada jejen (Phlebotomus y Lutzomyia), la cual es una transmisora del parásito de Leishmania, mismo que produce lesiones cutáneas. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.531336v1?rss=1 Authors: Banerjee, S., Gadpayle, M. P., Das, S., Samanta, S., Datta, R., MAITI, S. Abstract: PDZ protein interacting specifically with Tc10 or PIST is a mammalian trans-Golgi resident protein that regulates subcellular sorting of plasma membrane receptors. PIST has recently been found to play an important role in regulating viral pathogenesis. Alteration in PIST expression is linked to the reprogramming of cell surface receptors which is crucial in determining herpes simplex virus1 infection. In this context, PIST is crucial in triggering autophagy via Beclin 1 -PI3KC3 pathway. However, there is complete lack in our knowledge on the role of this protein in any parasitic infection. Leishmania parasites infect their host macrophage cells via phagocytosis and their survival within the parasitophorous compartment has recently been found to be dependent on host autophagy by a yet to be identified mechanism. Using Leishmania major (L. major)- macrophage infection model system we, for the first-time report here that in infected macrophages Golgi resident PIST protein migrates towards the parasite containing compartment. We have also found that PIST associates with Beclin 1, however, not with LC3 within the L. major parasite containing compartment of infected macrophages. Further, we performed genetic ablation of PIST by siRNA and observed that knockdown of macrophage PIST in turn helps in parasite replication. Contrary to this, overexpression of PIST in macrophages restricted the multiplication of L. major. Collectively, our study for the first time reveals that PIST is essential in regulating intracellular parasite, L. major infection within macrophage cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

A leishamniose é uma doença de grande importância na medicina veterinária e Saúde Pública, causada pelo protozoário do gênero Leishmania spp, é considerada uma zoonose, causando sofrimento não só para seres humanos, mas também para os cães. Para responder às dúvidas mais comuns sobre esse tema, convidamos o Prof. Dr. Arlei Marcii, graduado em Ciências Biológicas Modalidade Médica pela Universidade Bandeirante de São Paulo, atua na linha de pesquisa de Doenças Parasitárias, Infecciosas e Zoonoses com ênfase em parasitas do gênero Trypanosoma e Leishmania.

Cecilia Castillo, voluntaria de la protectora APAP Alcalá, nos habla en Como el Perro y el Gato de Dulce, una perrita de 3 años muy cariñosa y sociable a la que no consiguen encontrar una familia que la quiera debido a que padece Leishmania, a pesar de que la enfermedad está completamente controlada.

Presentado por el veterinario Carlos Rodríguez. Iván Cortés nos lee la carta de un caballo en Gran Canaria que se escapó de su cuadra y fue atrapado corriendo por la autopista. Ana Anglada nos ayuda a resolver el conflicto de una gata de 13 años que no tolera a un gato joven recién llegado a casa. Marta Bravo nos explica en qué época crían las cigüeñas. Conocemos a Dulce, una perrita con Leishmania que lleva mucho tiempo esperando un hogar en APAP Alcalá y a las dos agentes de Policía Local de La Vall d'Uixó que rescataron a 3 cachorros de un contenedor. Con la producción de Beatriz Ramos y realización de Jorge Zamorano.

Cuidado de mascotas. Leishmania canina. Clínica Colón de Linares, Estrella Villén. 

Tras una denuncia, el SEPRONA realiza una inspección en la finca de una mujer mayor y se encuentra a más de 50 animales (perros, gatos, un poni, un cerdo vietnamita) en una situación lamentable: sarna, tumores, infecciones, pulgas, úlceras, graves enfermedades, extremada delgadez... En este interesante episodio hablamos con la abogada penalista Manuela Perea, que llevó el caso como acusación popular con la Asociación de Abogados en Defensa Animal de Tarragona (ADAT).Dedicado a Nala y Canela.Enlaces relacionados:Asociación de Abogados en Defensa Animal de Tarragona (ADAT)https://www.facebook.com/ADATgnGaia Tarragona, Asociación de protección animalhttps://www.facebook.com/GAIA.Tarragona/Fundación Santuario Gaiahttps://www.fundacionsantuariogaia.org/'Un saco de canicas', Joseph Joffohttps://www.penguinlibros.com/es/novela-historica/315792-libro-un-saco-de-canicas-9788466363143'Auschwitz, última parada', Eddy de Windhttps://www.planetadelibros.com/libro-auschwitz-ultima-parada/302134

En Como el Perro y el Gato hemos hablado con Blanca Fernández, voluntaria de la protectora Amores Incondicionales, a los que recientemente han sufrido un asalto en su refugio para llevarse a Siria, una galga enferma de Leishmania que necesita su medicación para poder sobrevivir.

Joining Anthony for today's episode of VETchat is Ian Wright, Veterinary Surgeon and Parasitologist at the Mount Veterinary Practice, Fleetwood. In this episode, Anthony and Ian discuss a whole lot of parasitology! They talk about Animal Health Certificates; what they are, what is needed for them, and their benefits and drawbacks. Anthony asks Ian for his opinion on the government removing the compulsory treatment of ticks when animals travel and the dangers of bringing parasites over from other countries. Ian shares information on parasites including Rhipicephalus, Leishmania, Toxocara, and the risk that Phortica Variegata may bring to the UK. They discuss whether we are still over-treating animals and whether Ian thinks we should be doing more surveillance such as flea comings and faecal egg counts.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.20.513059v1?rss=1 Authors: Myburgh, E., Geoghegan, V., Alves-Ferreira, E. V. C., Nievas, Y. R., Grewal, J. S., Brown, E., McLuskey, K., Mottram, J. C. Abstract: Leishmania parasites undergo differentiation between various proliferating and non-dividing forms to adapt to changing host environments. The mechanisms that link environmental cues with the parasite's developmental changes remain elusive. Here, we report that Leishmania TORC1 is a key environmental sensor for parasite differentiation in the sand fly-stage promastigotes and for replication of mammalian-stage amastigotes. We show that Leishmania RPTOR1, interacts with TOR1 and LST8. We investigate TORC1 function by conditional deletion of RPTOR1, where under nutrient rich conditions RPTOR1 depletion results in decreased protein synthesis and growth, G1 cell cycle arrest and premature differentiation from proliferative promastigotes to non-dividing mammalian-infective metacyclic forms. These parasites cannot develop into proliferative amastigotes in the mammalian host, or respond to nutrients to differentiate to proliferative retroleptomonads, which are required for their blood-meal induced amplification in sand flies and enhanced mammalian infectivity. RPTOR1-dependent TORC1 functionality represents a critical mechanism for driving parasite growth and proliferation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Entre los entornos urbanizados que ofrecen hábitats idóneos para los flebótomos, además de las zonas ajardinadas y espacios urbanos donde se acumulen restos vegetales y basuras, también han colonizado los sistemas de alcantarillado, como se constató en un estudio sobre las ratas de alcantarilla en Barcelona en el 2019, en el que se halló un elevado porcentaje de ratas infectadas por Leishmania y una alta presencia de flebotomos en el alcantarillado barcelonés. Expertos en Leishmaniosis Autoras: Ana Montoya, LV, PhD, Acreditada AVEPA, Diplomada por el Colegio Europeo, Profesor Contratado Doctor del Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid y Marta Mateo, LV, PhD, Profesora Ayudante Doctora. Facultad de Farmacia. Universidad Complutense de Madrid

Dr. Susanne Franssen, an assistant professor of evolutionary biology at the Ludwig-Maximilians-Universität in Munich, Germany, and Sarah Gregory discuss vertical transmission of Leishmania infantum parasites in hunting dogs in the United States.

Paul Denny is the Director of the Centre for Global Infectious Diseases at Durham University and undertook PhD studies at the MRC National Institute for Medical Research focused on the vestigial plastid of the apicomplexan protozoa. Subsequently during research posts at Imperial College he developed interests in the molecular, biochemical and cellular biology of kinetoplastid protozoan parasites, most notably lipid biosynthesis in Leishmania species. Since his arrival at Durham University in 2004 Paul has used multidisciplinary approaches to study and exploit novel drug targets within both kinetoplastid and apicomplexan pathogens. --- Support this podcast: https://anchor.fm/out-of-the-blank-podcast/support

Ocurrió en Casabermeja, Málaga. El cazador y rehalero titular de Hero, una perritadiagnosticada con varias dolencias graves, la dejó encerrada en una furgoneta a plenosol durante días, en lugar de prestarle los cuidados que necesitaba.Hablamos con el abogado José Luis Mota, que ejerció la acusación particular con laasociación protectora de animales Ladram, sobre una sentencia condenatoria que hallegado hasta el Tribunal Supremo. Escuchamos también el testimonio de losresponsables de Ladram.Enlaces relacionados:Ladram: https://www.facebook.com/ladram.org/'Un mundo feliz', Aldous Huxley - https://es.wikipedia.org/wiki/Un_mundo_feliz'Algo supuestamente divertido que nunca volveré a hacer', David Foster Wallace -https://es.wikipedia.org/wiki/Algo_supuestamente_divertido_que_nunca_volver%C3%A9_a_hacer'El nombre del viento', Patrick Rothfuss -https://es.wikipedia.org/wiki/El_nombre_del_viento'Don Quijote de la Mancha', Miquel de Cervantes -https://es.wikipedia.org/wiki/Don_Quijote_de_la_Mancha

The TWiP team solves the case of the Man with a Cat and Ring Enhancing Lesions, and discuss domestic mammals as reservoirs for Leishmania donovani on the Indian subcontinent. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Reservoirs for Leishmania (Transboundary Emerg Dis) Support MicrobeTV at Parasites Without Borders Letters read on TWiP 201 Become a patron of TWiP Case Study for TWiP 201 Older male, >65, abdominal pain over last several months, getting worse, otherwise feels well. No change in weight. Past medical, surgical unremarkable. Social: grew up in rural inland China. As adult lived in large city. Always active and healthy, eating fish and leafy vegetables. Move to US 10 years before illness. No pets. No toxic habits. HIV negative. Unremarkable exam. Labs: elevated white count, platelets low, not anemic. Differential on white count: neutrophils predominant. Gets belly CT: reveals mass in colon. Colonoscopy done, mass resected. Pathology: shows adenocarcinoma, but also eggs in sample. Slightly ovoid, 80 microns. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

En este programa de 'Como el Perro y el Gato', Carlos Rodríguez entrevista a la dueña de Spok, un perro adoptado con Leishmania al que le han ayudado en su enfermedad el fortificante natural de Anima Strath. Presentado por Carlos Rodríguez e Iván Cortés. Con la colaboración de Io Almagro. Producido por Beatriz Ramos y con la realización de Jorge Zamorano.

A Leishmania traz muitos desafios. Quando o animal apresenta uma carga parasitária alta, os exames de sangue podem levar rapidamente ao diagnóstico, mas e quando essa carga é baixa? Neste episódio, contamos com a participação do colaborador do Vetsapiens Dr. Marcio Moreira, médico veterinário de São Paulo, responsável técnico pelo Centro de Diagnóstico e Banco de Sangue Sanimvet. Ele traz informações sobre as possíveis manifestações clínicas e métodos de diagnóstico mais específicos, tais como testes sorológicos, parasitológicos, técnicas de imunomarcação e amplificação do DNA do parasito pelo método de PCR, e claro, também discorre sobre o tratamento. Compartilhe com os colegas! Conecte-se com o Vetsapiens! www.vetsapiens.com https://www.facebook.com/vetsapiens https://www.instagram.com/vetsapiens/

When we bring dogs from far away into Canada, it is essential that we consider infectious organisms they may also bring into our country as “tag-alongs”. This a veterinarian and molecular-parasitology researcher (who is devoted to tackling zoonotic parasites) shares details on which infections should be top of mind when importing dogs, and describes a cautionary tale of an imported parasitic disease, Leishmania infantum.  Anyone who has been working in veterinary clinics throughout the pandemic will be all-too-aware of the increase in pet-ownership, and specifically, puppy and dog adoption, occurring throughout the past little while. Sometimes it seems that everyone, everywhere is on the hunt for a new furry companion to add to the family, and veterinarians have certainly had their hands full trying to keep up to the increased demand for veterinary medical services. Dog breeders in Canada are taking reservations years into the future for puppies, and prices for puppies are rising. Pet rescue organizations have also been scrambling to fill this “puppy void” – and increasing numbers of dogs are imported into Canada each year from far off locations. Sometimes these dogs are imported from countries where they have a drastically different climate, and potentially very different parasite and infectious disease threats for both dogs and humans. It is impossible to keep every single infectious disease front and centre in our minds, but veterinarians know that when something seems weird or unusual, we need to call in some help. In 2020, this is exactly what happened in Quebec, Canada, when multiple veterinarians noticed some  unusual things in their canine patients. And, as it turns out, these unusual findings were all observed in dogs that were imported to Canada.  Dr. Christopher Fernandez-Prada played an instrumental role in helping veterinarians investigate cases of Leishmania infantum, a parasitic infection. Dr. Fernandez-Prada is currently Director of the parasitology diagnostic laboratory and an assistant professor at the University of Montreal. In addition, he is also an Adjunct professor at McGill University faculty of Medicine, Deputy director of the Animal Infectious Diseases Research Group, and he is a member of the steering committee of the Canadian Network in Neglected Tropical Diseases. Recently, Dr. Fernandez Prada was the first veterinarian to receive the Canadian Institutes of Health Research prize – the Bhagirath Singh Early Career Award in Infection and Immunity.  Links of Interest:  Leishmania infantum infection in a dog imported from Morocco. Wagner V, Douanne N, Fernandez-Prada C. Leishmania infantum infection in a dog imported from Morocco. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne. 2020 Sep;61(9):963-965. PMID: 32879521; PMCID: PMC7424924._ A flesh-eating parasite carried by dogs is making its way to North America. Victoria Wagner, Christopher Fernandez-Prada, Martin Olivier. The Conversation, Oct. 21, 2020.  Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites Douanne N, Dong G, Douanne M, Olivier M, Fernandez-Prada C (2020) Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites. PLOS Neglected Tropical Diseases 14(7): e0008439. https://doi.org/10.1371/journal.pntd.0008439 Dr. Christopher Fernandez-Prada and his research  

Toute personne ayant travaillé dans une clinique vétérinaire pendant la pandémie sait trop bien que les adoptions d'animaux de compagnie, en particulier de chiots et de chiens, sont en hausse depuis quelque temps. On dirait parfois que tout le monde, partout, est en quête d'un nouveau compagnon à fourrure à ajouter à la famille, et les médecins vétérinaires sont très occupés à essayer de suffire à la demande accrue pour les services de santé vétérinaire. Les éleveurs de chiens du Canada prennent des réservations plusieurs années d'avance pour fournir des chiots, et les prix de ces chiots augmentent. Les organismes de sauvetage d'animaux de compagnie font aussi des pieds et des mains pour combler ce « manque de chiots » – et de plus en plus de chiens d'endroits éloignés sont importés au Canada chaque année. Ils viennent parfois de pays où le climat est radicalement différent et où des parasites et des maladies infectieuses très différents peuvent poser une menace pour la santé des chiens et des humains. Quand nous importons des chiens de très loin, il est essentiel de penser aux petits « passagers » contagieux qu'ils peuvent apporter avec eux dans notre pays. Dr Fernandez-Prada est un médecin vétérinaire et chercheur en parasitologie moléculaire spécialiste des parasites zoonotiques. Il est directeur du laboratoire de diagnostic en parasitologie et professeur adjoint à l'Université de Montréal. Il est aussi professeur associé à la Faculté de médecine de l'Université McGill, directeur adjoint du Groupe de recherche sur les maladies infectieuses en production animale et membre du comité directeur du Réseau canadien pour les maladies tropicales négligées. Et il est récemment devenu le premier médecin vétérinaire à recevoir le prix Bhagirath-Singh de début de carrière en recherche en maladies infectieuses et immunitaires décerné par les Instituts de recherche en santé du Canada. Liens d'intérêt: Infection par Leishmania infantum chez un chien importé du Maroc. (Wagner V, Douanne N, Fernandez-Prada C. Leishmania infantum infection in a dog imported from Morocco. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne. 2020 Sep;61(9):963-965. PMID: 32879521; PMCID: PMC7424924._) A flesh-eating parasite carried by dogs is making its way to North America. Victoria Wagner, Christopher Fernandez-Prada, Martin Olivier. The Conversation, Oct. 21, 2020.  Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites Douanne N, Dong G, Douanne M, Olivier M, Fernandez-Prada C (2020) Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites. PLOS Neglected Tropical Diseases 14(7): e0008439. https://doi.org/10.1371/journal.pntd.0008439 Dr. Christopher Fernandez-Prada et ses recherches  

Semana Nacional de Controle e Combate à Leishmaniose tem início nesta segunda-feira (09) no Maranhão. A programação vai até esta sexta-feira (13). Doença infecciosa, porém não contagiosa, causada por parasitas do gênero Leishmania. Os parasitas vivem e se multiplicam no interior das células que fazem parte do sistema de defesa do indivíduo, chamadas macrófagos.

Description: During this episode, Dr. Claudia Cohn will provide background on the role of antibody titers for diagnosis and monitoring performed in the transfusion medicine lab and its clinical applications. About our Speaker:  Dr. Claudia S. Cohn is the medical director of the blood bank laboratory and associate medical director of the HLA laboratory at the University of Minnesota.  She earned her Ph.D. in Immunology and Infectious Diseases from the Bloomberg School of Public Health at Johns Hopkins, working on the molecular biology and biochemistry of the protozoal; parasite Leishmania donovani. She went on to earn her medical degree from Louisiana State University School of Medicine in New Orleans, LA. After medical school, she finished a residency program in Pathology at New York-Presbyterian Hospital, Weill-Cornell College of Medicine, and a fellowship in Transfusion Medicine at the University of California, San Francisco.  In her current role at the University of Minnesota, she practices Clinical Pathology, oversees the blood bank, and teaches medical students.  Dr. Cohn’s research interests include platelet transfusions, alternative platelet storage solutions, HLA antibodies, and their role in solid organ transplants and platelet refractoriness. She focuses her efforts in two areas: patient blood management and platelet storage and utilization. Dr. Cohn was named in 2020 chief medical officer (CMO) for the AABB organization where she works to strategize and implement ways that achieve AABB’s mission through the development of policies and by engaging the communities it serves. 

En el episodio de hoy, con la cercanía de las fechas de calor, vamos a hablar de los mosquitos y demás parásitos externos que tantos problemas pueden dar a nuestras mascotas. Pero antes de comenzar, ya sabes que todo lo que necesites para tus mascotas lo puedes encontrar en Petsworldmarket.com y en nuestras tiendas de mascotas , clínicas veterinarias y hotel para mascotas situados en la provincia de Alicante (Torrevieja, San Miguel de Salinas y La Zenia). Con el inicio de la época de calor es habitual que nos encontremos con las temidas garrapatas, pulgas y mosquitos. Los anteriores son transmisores de enfermedades muy importantes para nuestras mascotas. En concreto, hay que tener mucho cuidado con los mosquitos que transmiten la Leishmaniosis. La Leishmaniosos es una enfermedad protozoaria que transmite un mosquito llamado flebotomo. Esta enfermedad provoca graves lesiones en los perros. Además, es una enfermedad que puede transmitirse al ser humano. Es tan grave que puede provocar la muerte del animal. Actualmente no existen tratamientos totalmente efectivos que curen el perro una vez se ha infectado.  Existe una combinación de tratamientos para intentar prevenir la Leishmania. Medios para prevenir la Leishmaniosis Existen varias formas de prevenir la Leishmania en nuestros perros. Por un lado tenemos los collares y pipetas y por otro lado tenemos las vacunas. La vacuna es una muy segura y aunque no tenga un porcentaje de efectividad del 100% es muy recomendable ponérsela a los perros. Desde Petsworld aconsejamos utilizar ambas medidas. La recomendación de protección que damos es: Utilizar collar o pipetaVacunar al perro con la vacuna de la Leishania. Destacar que productos como las tabletas que previenen a los parásitos no actúan frente al mosquito. Si utilizamos estas tabletas debemos utilizar cualquier otro método para proteger a nuestro animal frente a los mosquitos. Oferta en diagnóstico y vacunación contra la Leishmaniosis Durante el mes de mayo tendrás disponible en las clínicas veterinarias Petsworld situadas en Torrevieja, San Miguel de Salinas y La Zenia (Orihuela Costa) una campaña de diagnóstico de la leishmania y grandes descuentos tanto en los test de diagnostico como en la vacunación. ¡No dejes pasar esta oportunidad!. Muchas gracias por escuchar el podcast, esperamos que te haya sido de ayuda. Si te ha gustado el podcast puedes dejarnos una valoración en tu aplicación de Podcast favoritay como siempre, cualquier otra cosa que necesites nos tienes disponibles en nuestras tiendas de mascotas , clínicas veterinarias y en Petsworldmarket.com .

Objetivos terapéuticos: mejoría clínica y reducción de la transmisión. Xenodiagnóstico post-tratamiento. Arsenal terapéutico: leishmanicidas, leishmaniostáticos, inmunomoduladores y otras terapias. Estadiaje antes del tratamiento. Seropositividad y clínica. Tratamientos complementarios. Dieta. ¿Y si no responden? Autora: Guadalupe Miró, Catedrática del Dpto. de Sanidad Animal. Responsable de la Consulta de Patología Infecciosa y Parasitaria, Facultad de Veterinaria. Universidad Complutense de Madrid

Cambios en la epidemiología de la leishmaniosis canina. Actualidad. Dispersión de casos positivos. Centro y Norte de Europa y España. Casos autóctonos en zonas no endémicas. Nuevos reservorios. Hospedadores supertransmisores. Tiempo de riesgo de exposición al vector y Estado inmunitario. Cambio climático, islas térmicas. España peninsular y Baleares: áreas hipoendémicas, endémicas e hiperendémicas. Cambios biológicos de Leishmania: nuevas vías de transmisión. Vertical y sexual en zonas no endémicas. Autora: Guadalupe Miró, Catedrática del Dpto. de Sanidad Animal. Responsable de la Consulta de Patología Infecciosa y Parasitaria, Facultad de Veterinaria. Universidad Complutense de Madrid

In this episode, we interview Cody Poe, a PhD Student at the University of Iowa. We talk about Mike Tyson, how to talk to COVID deniers, why Leishmania is a dangerous pathogen despite its cool-sounding name, and how engaging in ritual combat makes you a better public speaker. "Cool Vibes" by Kevin MacLeod (incompetency.com) Licensed under Creative Commons: By Attribution 3.0 License

La leishmaniosis se considera endémica en toda la zona del mediterráneo, y el perro es el principal reservorio de la enfermedad. Generalmente, la leishmaniosis canina se transmite mediante un vector, el insecto del género Phlebotomus, que inyecta el parásito de la Leishmania infantum al picar al perro. Leishmania infantum es un protozoo intracelular obligado, que vive y se reproduce en los diferentes órganos, provocando una afectación sistémica y un deterioro progresivo del animal. A lo largo de este episodio hablaremos sobre el manejo farmacológico de la leishmaniosis y sobre las necesidades nutricionales específicas de los animales afectados. Sigue nuestros canales oficiales: 👉🏽Twitter: https://twitter.com/VetsAndClinics 👉🏽Linkedin: https://www.linkedin.com/showcase/vet... Si quieres más información sobre la Leishmaniosis visita nuestro blog https://www.affinity-petcare.com/vetsandclinics/es

La leishmaniosis se considera endémica en toda la zona del mediterráneo, y el perro es el principal reservorio de la enfermedad. Generalmente, la leishmaniosis canina se transmite mediante un vector, el insecto del género Phlebotomus, que inyecta el parásito de la Leishmania infantum al picar al perro. Leishmania infantum es un protozoo intracelular obligado, que vive y se reproduce en los diferentes órganos, provocando una afectación sistémica y un deterioro progresivo del animal. A lo largo de este episodio hablaremos sobre el manejo farmacológico de la leishmaniosis y sobre las necesidades nutricionales específicas de los animales afectados. Sigue nuestros canales oficiales: 👉🏽Twitter: https://twitter.com/VetsAndClinics 👉🏽Linkedin: https://www.linkedin.com/showcase/vet... Si quieres más información sobre la Leishmaniosis visita nuestro blog https://www.affinity-petcare.com/vetsandclinics/es

Dr Ciara Clarke talks to Oli about Alabama Rot and emerging infectious diseases such as Leishmania, Ehrlichia, Babesia. Plus all you need to know if you want to travel to Europe from the UK with your dog or pets.Alabama Rot map - www.vets4pets.com/pet-health-advice/alabama-rot/ARRF charity website with up to date information and research - www.arrf.co.uk/Sponsors - Tractive.com GPS Pet Trackers 20% off a Tracker - click above or visit www.tractive.com/?dogsbestfriend for automatic discount.Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.

Na brincadeira do "telefone sem fio" crianças se reúnem para rir de como nós, humanos, escolhemos passar uma determinada informação e como isso é entendido por um interlocutor. À medida que vários são os participantes o conteúdo passa por modificações.  Como vocês ouvirão neste episódio, entre a ideia de uma pesquisa científica, e seus achados, até o público leigo naquele assunto pode haver uma série de interferências das mais diversas ordens e causas. Especificamente nesse episódio do Ciência sem Fio o Crhis Vasconcelos conta o que ela estuda e os demais participantes, num telefone sem fio virtual, vão contanto uns aos outros o que cada um entendeu sobre o assunto. Assim, pode ser que no caminho algumas informações e partículas tenham sido perdidas! Talvez protozoário tenha virado bactéria e em vez de pedras em engrenagens tenhamos colocado óleo! Nos conte o que você entendeu!

Na brincadeira do "telefone sem fio" crianças se reúnem para rir de como nós, humanos, escolhemos passar uma determinada informação e como isso é entendido por um interlocutor. À medida que vários são os participantes o conteúdo passa por modificações.  Como vocês ouvirão neste episódio, entre a ideia de uma pesquisa científica, e seus achados, até o público leigo naquele assunto pode haver uma série de interferências das mais diversas ordens e causas. Especificamente nesse episódio do Ciência sem Fio o Crhis Vasconcelos conta o que ela estuda e os demais participantes, num telefone sem fio virtual, vão contanto uns aos outros o que cada um entendeu sobre o assunto. Assim, pode ser que no caminho algumas informações e partículas tenham sido perdidas! Talvez protozoário tenha virado bactéria e em vez de pedras em engrenagens tenhamos colocado óleo! Nos conte o que você entendeu!

In this episode of the podcast, Laura speaks with Dr Rod Dillon, Senior Lecturer at the University of Lancaster. Rod talks about his research into the protist parasite Leishmania, and how he has combined his microbiology expertise with art to communicate science in a different way. Rod recently received a grant from the Microbiology Society this, together with an Arts Council England grant, was used to develop and produce The Endosymbiotic Love Calendar 2021. The calendar is on sale now on the Endosymbiotic Love Calendar website. This project brings performance artists & microbiologists together through drag to embody a microorganism for every month of 2021 and links the vitally important world of microbiological research with feminist and queer perspectives to share biological knowledge in an innovative way. Prices include postage: £15 UK mainland (£12 concession price, no question asked), £19 Europe, £20 rest of the world. 50% of the price will be donated to The Outside Project the UK’s first LGBTIQ+ Crisis/Homeless Shelter and Community Centre.

La leishmaniosi è una malattia infettiva e contagiosa causata da un protozoo chiamato Leishmania infantum.Questo protozoo infetta i flebotomi, dei piccoli insetti responsabili della trasmissione noti come pappataci. I pappataci si trovano ormai su tutto il territorio nazionale e soprattutto nelle zone centro-meridionali, vicino alle coste e agli Appennini. Riescono a vivere da maggio a novembre e infatti muoiono con l'arrivo dell'inverno. Il clima temperato, l'ambiente collinare o costiero sono il loro habitat preferito.Il cane e anche altri mammiferi come il gatto o il coniglio, grazie anche alla loro temperatura corporea generalmente più elevata di quella ambientale, sono animali molto apprezzati da pappataci.Il cane si ammala quando avviene una risposta anomala del sistema immunitario porta ad un'eccessiva produzione di anticorpi. Ecco perché alcuni soggetti infetti non presentano sintomi per anni o per tutta la vita, mentre altri hanno delle manifestazioni molto gravi.Puoi proteggere il tuo animale usando da maggio a novembre dei farmaci antiparassitari che blocchino il morso dei pappataci. Sono disponibili anche i vaccini, che però non sono in grado di evitare l'infezione ma solo di ridurre la probabilità di andare incontro ai sintomi della patologia.La diagnosi di infezione si basa indirettamente sull’evidenziazione di anticorpi contro Leishmania infantum, seguita dalla evidenziazione diretta del protozoo in alcuni distretti corporei (midollo osseo, linfonodi).In caso di positività la diagnosi di infezione è certa, ma è bene ricordare che un cane può essere clinicamente sano anche in caso di risultati positivi, e quindi può non necessitare di alcun trattamento.La cura si basa sulla somministrazione di farmaci in grado di uccidere la maggior parte delle Leishmanie per cercare di controllare l’infezione, anche se purtroppo la guarigione completa di un soggetto infetto è considerata un'eccezione.Per questo motivo la prevenzione dal morso dei pappataci e l’attenzione verso il proprio animale sono di fondamentale importanza.

This episode covers leishmania donovani!

In this episode Dr's J, Santhosh, and ER Josh cover Leishmaniasis. Along the way they discuss an Israeli camping trip gone wrong, jewish mothers and social media, white leprosy, British colonialism, kala-azar and Jericho buttons, cute disease names, Dum Dum fever, medical etymology, sandflies, disease transmission and locations, diagnosis, Aladdin parodies, vampire slayers, cutaneous and viseral leishmaniasis symptoms, treatments, and drugs for neglected diseases. So Sit back and join in on the Leishmania! Contact Us! Twitter: @doctorjcomedy @toshyfro @travelnmedicine Facebook: facebook.com/travelmedicinepodcast Rate Us! itunes: https://itunes.apple.com/us/podcast/episodes-travel-medicine-podcast/id914407095 stitcher: http://www.stitcher.com/podcast/travel-medicine-podcast?refid=stpr