#ExpertAnswers - an InsideScientific Podcast

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#ExpertAnswers is a podcast by InsideScientific, the online environment for Life Science webinars, virtual events, interviews and educational content that helps you do your best work. On this channel, we will be featuring discussions with experts as they

InsideScientific


    • Jul 6, 2023 LATEST EPISODE
    • infrequent NEW EPISODES
    • 11m AVG DURATION
    • 259 EPISODES


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    Latest episodes from #ExpertAnswers - an InsideScientific Podcast

    #ExpertAnswers: Jack Vanden Heuvel on Nuclear Receptor Profiling

    Play Episode Listen Later Jul 6, 2023 5:29


    Dr. Jack Vanden Heuvel from Penn State University answers questions from a recent webinar discussing the use of cell-based reporter assays for nuclear receptor profiling to efficiently prioritize drug candidates and minimize off-target effects. For more information or to watch the webinar, click here.

    #ExpertAnswers: Steven Loo-Yong-Kee on CRISPR-Edited T Cells

    Play Episode Listen Later Jul 4, 2023 6:36


    Steven Loo-Yong-Kee highlights Artisan Bio's STAR-CRISPR system for optimized gene editing in cell therapy, with a focus on the genetic modification of T cells for cancer immunotherapy.

    #ExpertAnswers: Sam Sternberg on Genome Engineering

    Play Episode Listen Later May 12, 2023 11:50


    Sam Sternberg discusses a novel CRISPR-Cas9 system using programmable, RNA-guided transposase and highlighting its implications for genome engineering in cell and gene therapies.

    #ExpertAnswers: Kaitlynn Arnholt and Elaine Nam on Lab-Based Learning

    Play Episode Listen Later May 8, 2023 13:16


    Kaitlynn Arnholt and Elaine Nam discuss how the collaboration between ADInstruments and Vernier Science Education enhances lab-based learning.

    #ExpertAnswers: Kosuke Minamihata and Jes Kuruvilla on Synthetic Peptides for Regenerative Medicine

    Play Episode Listen Later May 5, 2023 17:25


    Kosuke Minamihata and Jes Kuruvilla discuss how synthetic growth factors work and give application examples using these synthetic peptides for cell therapy and regenerative medicine.

    #ExpertAnswers: Fan Wu and Lidor Spivak on Electrophysiological Data Analysis using Artificial Intelligence

    Play Episode Listen Later May 4, 2023 16:32


    Fan Wu and Lidor Spivak discuss automating electrophysiological data analysis using artificial intelligence and introduced a new cloud-based platform applying these methods.

    #ExpertAnswers: Nataliia Beztsinna and Marten Hornsveld on Pre-Clinical Immuno-Oncology

    Play Episode Listen Later May 3, 2023 10:16


    Nataliia Beztsinna and Marten Hornsveld describe how the tumor microenvironment modulates clinical responses and how patient-derived ex vivo and engineered in vitro models can be used for pre-clinical immuno-oncology testing.

    #ExpertAnswers: Frauke Greve and Anna Borgström on Hepatic Safety Using 3D Liver Spheroids

    Play Episode Listen Later May 1, 2023 14:55


    Frauke Greve and Anna Borgström from InSphero highlight the latest advancements in hepatic safety assessment using 3D liver spheroids.

    #ExpertAnswers: Gethin Evans on Life Science Education Delivery

    Play Episode Listen Later Apr 26, 2023 7:32


    Gethin Evans delves into his experience teaching in the life sciences pre-, during, and post-pandemic and how his department invested in technology to assist with teaching content and delivery during the pandemic.

    #ExpertAnswers: Jane Kusch and Marc Demolder on Technology-Enhanced Education

    Play Episode Listen Later Apr 11, 2023 12:31


    Jana Kusch, PhD and Marc Demolder, MSc, answer questions from a recent webinar where they discuss their experience with technology-enhanced education.

    #ExpertAnswers: Patricia Halpin on the Uses of Technology for Teaching Physiology Online

    Play Episode Listen Later Apr 6, 2023 11:03


    Patricia Halpin answers questions from a recent webinar where she discusses how she harnesses technology to engage her physiology students in an online clinical pathophysiology course.

    #ExpertAnswers: Marcel Perret-Gentil on Improving Surgical Outcomes

    Play Episode Listen Later Apr 5, 2023 11:30


    Marcel Perret-Gentil presents six simple-to-implement techniques to significantly improve surgical outcomes, to lessen post-op mortality and improve data yield after surgery.

    improving gentil perret surgical outcomes
    #ExpertAnswers: Davide Boido and Antoine Bergel on Multimodal Neuroimaging

    Play Episode Listen Later Mar 15, 2023 14:45


    Davide Boido and Antoine Bergel discuss their work on how state-of-the-art multimodal neuroimaging can be coupled with functional ultrasound to study neurovascular coupling across vigilance states.

    #ExpertAnswers: Jastyn Pöpplau and Marilena Hnida on Prefrontal Networks

    Play Episode Listen Later Mar 10, 2023 11:38


    Jastyn A. Pöpplau and Marilena Hnida discuss their research on prefrontal networks in developing head-fixed mice, and the role of these networks in cognition and models of neurodevelopmental diseases. 

    #ExpertAnswers: Artur Fedorowoski on Cardiovascular Dysautonomia in Post-COVID-19

    Play Episode Listen Later Mar 8, 2023 12:08


    Artur Fedorowski explains CV dysautonomia as a specific sequalae of acute COVID-19 and guides the audience in the diagnostic work-up of PASC patients with suspected cardiovascular complications.

    #ExpertAnswers: Connar Westgate on Intracranial Pressure Measurements

    Play Episode Listen Later Dec 29, 2022 11:50


    Connar Westgate discusses his research involving intracranial pressure measurements and the importance of understanding this physiological parameter for maintaining normal central nervous system function.

    #ExpertAnswers: Audrey Dubourg and Gareth Guenigault on the Organ-On-A-Chip Approach

    Play Episode Listen Later Dec 29, 2022 13:28


    Audrey Dubourg and Gareth Guenigault from CN Bio discuss the value that an organ-on-a-chip approach can bring to drug discovery and development workflows, and how the regulatory landscape is shifting to encourage their widespread adoption.

    #ExpertAnswers: Sarah Greising on Muscle Injury Recovery

    Play Episode Listen Later Dec 22, 2022 9:30


    Sarah Greising discusses the current pathophysiologic understanding of the skeletal muscle remaining following traumatic musculoskeletal injuries.

    #ExpertAnswers: Marrit Putker, Saskia De Man, and Pirouz Daftarian on T Cell-Directed Immunotherapy

    Play Episode Listen Later Dec 15, 2022 10:22


    Marrit Putker, Saskia De Man, and Pirouz Daftarian from Crown Bioscience discuss T cell-directed immunotherapy on the cancer-immunity cycle, including mechanisms and targets capable of modulating and enhancing T cell activity and the application of methods and models including organoids and high content imaging.

    #ExpertAnswers: Dudley Lamming on the Influence of Sex and Genetic Background on Diet

    Play Episode Listen Later Dec 13, 2022 14:21


    Dudley Lamming, PhD, explains that “We Are More Than What We Eat”; Sex and Genetic background are important factors in observing responses to diet in mice.

    #ExpertAnswers: Phil Griffiths on Telemetry Studies

    Play Episode Listen Later Dec 12, 2022 7:43


    Phil Griffiths draws from his experience as a telemetry user to discuss some important considerations for designing telemetry studies.

    studies telemetry phil griffiths
    #ExpertAnswers: Cole McLarty, Nick Glover, and Tim Hacker on Pressure-Volume Loops

    Play Episode Listen Later Dec 9, 2022 10:19


    Cole McLarty, Nick Glover and Dr. Timothy Hacker focus on Pressure-Volume Loop collection and data analysis for cardiovascular research.

    #ExpertAnswers: George Portugal on Microelectrode Array Technology

    Play Episode Listen Later Dec 8, 2022 19:08


    George Portugal discusses microelectrode array (MEA) technology used for cardiac research and some best practices for integrating this technique into your research protocols.

    #ExpertAnswers: Dennis Turner on the Metabolics of Dementia

    Play Episode Listen Later Dec 5, 2022 15:13


    Dennis Turner delves into dementia syndrome, the metabolic changes that occur, and the importance of proper physiological monitoring of animal models.

    #ExpertAnswers: Rajendra Kumari and Gera Goverse on the Cancer Immunity Cycle

    Play Episode Listen Later Dec 2, 2022 7:40


    Rajendra Kumari and Gera Goverse provide an overview of the cancer immunity cycle and present several methods, techniques, and model systems for immuno-oncology research.

    #ExpertAnswers: Oscar Perez Leal and Jon Weidanz on Gene Editing

    Play Episode Listen Later Dec 1, 2022 5:07


    Oscar Perez Leal and Jon Weidanz discuss the basis of the FAST-HDR gene-editing system to create custom cell lines, and present case studies highlighting several applications.

    leal gene editing oscar perez
    #ExpertAnswers: Amy Sheng on Antibody Screening and Discovery

    Play Episode Listen Later Nov 30, 2022 8:18


    Amy Sheng provides an overview of antibody screening platforms and presents applications and case studies using the Beacon® platform for antibody discovery.

    #ExpertAnswers: Ejvind Mørtz on Protein Analysis

    Play Episode Listen Later Nov 29, 2022 12:01


    Ejvind Mørtz discusses the benefits and applications of mass spectrometry (MS)-based host cell protein (HCP) analysis and why HCP ELISAs are insufficient for documenting product-related impurities.

    #ExpertAnswers: Andrew Taylor on Drug Metabolism

    Play Episode Listen Later Nov 29, 2022 7:30


    Andrew Taylor provides an overview of processes by which drugs are metabolized and talks about the importance of drug metabolism and drug-drug interaction studies.

    #ExpertAnswers: Giacomo Rossitto on Heart Failure and Lymphatic Dysfunction

    Play Episode Listen Later Nov 29, 2022 14:40


    Giacomo Rossitto answers questions from a recent webinar where he shares his research on heart failure and the related lymphatic dysfunction in patients.

    #ExpertAnswers: Jonathan Brestoff on Energy Expenditure

    Play Episode Listen Later Nov 28, 2022 13:15


    Jonathan Brestoff explains how energy expenditure can be better described thanks to a new bioinformatic algorithm known as Clambake.

    #ExpertAnswers: Michael Sturek on Macrovascular Atherosclerosis and Microvascular Dysfunction

    Play Episode Listen Later Nov 25, 2022 8:07


    Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underlie ischemic events and the need for appropriate animal models for optimal translation.

    #ExpertAnswers: David Barefield on Atrial Dysfunction

    Play Episode Listen Later Nov 24, 2022 6:28


    David Barefield discusses his work investigating the role of the Myosin binding protein H-like (MyBP-HL) protein in atrial dysfunction.

    dysfunction atrial myosin barefield
    #ExpertAnswers: Eduardo Marbán on Regenerative Cardiovascular Medicine

    Play Episode Listen Later Nov 23, 2022 3:23


    Eduardo Marbán dives into the complexities of regenerative cardiovascular medicine and the future directions for cell therapies.

    #ExpertAnswers: Jason Rogers and Eliala Salvadori on Infant Emotional Communication

    Play Episode Listen Later Nov 22, 2022 8:13


    Jason Rogers and Eliala Salvadori answer questions from a recent webinar that discussed research involving infant emotional communication patterns and coded behaviors.

    #ExpertAnswers: Bradley Palmer on Measuring Cardiac Tissue

    Play Episode Listen Later Nov 21, 2022 18:27


    Bradley Palmer answers questions from a recent webinar where he highlighted and demonstrated the challenging preparation of cardiac tissue slices and measurement of force and calcium.

    #ExpertAnswers: Adrián Rodríguez-Contreras and Barbara Lind on Neurovascular Coupling

    Play Episode Listen Later Nov 16, 2022 11:03


    Adrián Rodríguez-Contreras and Barbara Lind discuss their work on neurovascular coupling in awake head-fixed and anesthetized mice, with a focus on the effects of anesthetics.

    #ExpertAnswers: Ana Briones on Targeting Inflammation and Vascular Damage in Hypertension

    Play Episode Listen Later Nov 15, 2022 9:54


    Ana Briones discusses her research on the effects and potential therapeutic targets of excessive inflammation and vascular damage in hypertension.

    #ExpertAnswers: Licy Yanes Cardozo on Androgens in Cardiovascular Physiology

    Play Episode Listen Later Nov 15, 2022 13:18


    Licy Yanes Cardozo expands on her research exploring the role of androgens on cardiovascular physiology in cis and transgender patients.

    cardozo yanes androgens cardiovascular physiology
    #ExpertAnswers: Aaron Phillips on Neural Hemodynamic Control

    Play Episode Listen Later Oct 25, 2022 12:18


    Aaron Phillips discusses questions from a recent webinar on his research involving neural hemodynamic control in pre-clinical and clinical models.

    neural hemodynamics aaron phillips
    #ExpertAnswers: Matthew Sparks on Vascular-Tubular Crosstalk

    Play Episode Listen Later Sep 27, 2022 11:00


    Matthew Sparks discusses his latest findings on a system of vascular-epithelial in the kidney that regulates pressure natriuresis.

    #ExpertAnswers: Valeria Fumagalli and Nancy Kouassi on the Syrian golden hamster model of COVID-19

    Play Episode Listen Later Aug 18, 2022 19:28


    Valeria Fumagalli and Nancy Kouassi discuss the Syrian golden hamster model of COVID-19, and present a new inhalation exposure-based mouse model using aerosolized SARS-CoV-2. 

    #ExpertAnswers: Bonnie Lun on Nanobodies for Research

    Play Episode Listen Later Aug 18, 2022 11:06


    Dr. Bonnie Lun from Fortis Life Sciences discusses applications and advantages of using nanobodies for diagnostic and therapeutic research, and highlights Fortis/Abcore's nanobody discovery services.

    #ExpertAnswers: Peter Ansell and Marian Navratil on Gene Expression Profiling

    Play Episode Listen Later Jul 25, 2022 10:18


    Peter Ansell and Dr. Marian Navratil discuss the use of novel RNA-based gene expression profiling technologies for clinical and preclinical oncology research.

    #ExpertAnswers: Louise Naylor on Exercise and the Cardiovascular System

    Play Episode Listen Later Jul 25, 2022 7:39


    Louise Naylor focuses on the benefits of exercise to optimize and maintain the cardiovascular system.

    #ExpertAnswers: Michael Long and Kari Hoffman on Electrophysiology

    Play Episode Listen Later Jul 20, 2022 9:13


    Michael Long and Kari Hoffman investigate the neural mechanisms of learning, memory, and behavior using high-density silicon probes from Diagnostic Biochips in small and large animals.

    #ExpertAnswers: Guto Montezano on COVID-19 and the Endothelium

    Play Episode Listen Later Jul 15, 2022 21:08


    Guto Montezano discusses the role of endothelial inflammation and ACE2 biology in COVID-19 infections and the resulting long-term effects.

    covid-19 guto endothelium
    #ExpertAnswers: Bastiaan Bijl and Dylan Mooijman on Single-Cell Sequencing

    Play Episode Listen Later Jun 24, 2022 9:06


    Bastiaan Bijl and Dylan Mooijman provide an introduction to single-cell sequencing including potential applications with user cases.

    #ExpertAnswers: Edward LeCluyse and Paul Gallant on a Novel Hepatic Triculture System

    Play Episode Listen Later Jun 22, 2022 7:36


    Edward LeCluyse and Paul Gallant discuss their novel all-human hepatic triculture system including its benefits and applications.

    system hepatic paul gallant
    #ExpertAnswers: Franck Lebrin and Denis Vivien on Ultrasound Imaging in Stroke and Neurovascular Diseases

    Play Episode Listen Later Jun 20, 2022 9:45


    Franck Lebrin and Denis Vivien discuss their work on microvascular and functional ultrasound imaging in stroke and neurovascular diseases.

    #ExpertAnswers: Yuning Chen on Antibody Production

    Play Episode Listen Later Jun 2, 2022 6:48


    Yuning Chen discusses strategies involved in recombinant antibody production and introduces a novel antibody expression platform to facilitate antibody library generation.

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