Podcasts about single cell

As Philip tours Amsterdam, he visits the biotech tools startup LUMICKS. Founded in 2014, the firm offers products analyzing the binding interactions between molecules and cells, with applications in drug development, CAR-T therapies, and manufacturing.Philip sits down with co-founder Gerrit Sitters to discuss the company's trajectory, the cyclic biotech investment market, and lessons from spinning the firm out from Vrije Universiteit Amsterdam.---Explore how LUMICKS' technology helps develop biologics and cell therapies with unique cell avidity data — http://bit.ly/lumicks---⭐️ ABOUT THE SPEAKERGerrit co-founded LUMICKS in 2014 following a PhD at Vrije Universiteit Amsterdam, and co-invented the technology behind LUMICKS' main products. Gerrit now serves as Head of Product, where he aims to deploy the company's products to tackle challenges in the life sciences.

The body of 27-year-old mother of two, Samantha Bodsworth, was found in Noosa, surrounded by wattle trees. The killer thinks it’s the perfect crime, but what they underestimated was the power of the tiny, silent witnesses clinging to almost everything they touched – pollen. In this Rewind episode of Crime Insiders | Forensics, former host Kathryn Fox talks to Dr Lynne Milne, the scientist at the forefront of forensic palynology. We learn how, for the first time in an Australian criminal case, pollen helped unmask a murderer. This episode references men's violence against women. If you or someone you know is experiencing, or at risk of experiencing, domestic, family or sexual violence, call 1800RESPECT on 1800 737 732, text 0458 737 732 or visit 1800RESPECT.org.au for online chat and video call services. The number for Life Line is 13 11 14.See omnystudio.com/listener for privacy information.

Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.

Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.

What happens when two leading computational biologists swap code and models for a lively conversation?Fabian Theis, a pioneer in single-cell and AI-driven biomedical research, joins Shai for a fascinating exchange about:— The single-cell revolution and how it's reshaping the industry.— The promise (and hype) of foundational models.— And why tomorrow's R&D lab might be a “virtual biotech” — or even a one-person operation!

What happens when two leading computational biologists swap code and models for a lively conversation?Prof. Fabian Theis — Director of the Computational Health Center at Helmholtz Munich, a pioneer in single-cell and AI-driven biomedical research, and a member of CytoReason's Science Advisory Board — joins Prof. Shai Shen-Orr, Co-Founder & Chief Scientist at CytoReason, to talk about:The single-cell revolution and how it's reshaping the industryThe promise (and the hype) of foundational modelsWhy tomorrow's R&D lab might be a “virtual biotech” — or even a one-person operationTune in for a lively exchange full of insights and big ideas.

In this episode, host Steve Lewis sits down with Giovanna Prout, President and CEO of Scale Biosciences, to explore how Scale is pushing the boundaries of single-cell omics. With a career that spans roles with big players and entrepreneurial ventures, Giovanna brings a unique perspective to the world of genomics innovation.Giovanna dives into Scale's patented Quantum Barcoding technology—a high-throughput, combinatorial indexing approach that allows researchers to process millions of cells and thousands of samples simultaneously, all without the need for specialized instrumentation. She explains how this flexible, automation-friendly platform is opening doors for AI-driven data modeling, large-scale drug screening, and highly diverse patient cohort studies.Beyond the science, Giovanna reflects on her leadership journey, emphasizing persistence, servant leadership, and a passion for making a difference in life sciences. She also shares the vision behind the 100 Million Cell Initiative, a bold collaboration that empowers scientists to dream big without constraints. For early-career scientists, Giovanna offers candid advice on working hard, staying curious, and believing in the impact of their work. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

In this week's episode, we'll learn more about the identification and characterization of stem cell-like leukemia blasts using single cell multi-omics, cyclophosphamide as a treatment for non-immune effector cell-associated neurotoxicity in patients treated with B-cell maturation antigen, or BCMA, targeted CAR T-cell therapies, and how differences in glycosylation affect the clearance of human plasma-derived and recombinant von Willebrand factor concentrates.Featured Articles:Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcomeCyclophosphamide mitigates non-ICANS neurotoxicities following ciltacabtagene autoleucel treatmentEnhanced α2-3–linked sialylation determines the extended half-life of CHO-rVWF

The emergence of foundation models has sparked interest in applications to single-cell biology, but when tested in zero-shot settings, they underperform compared to simpler methods. Alex Lu shares insights on why more research on AI models is needed in biological applications.Show notes

Commentary by Dr. Jijun Huang.

Michael Hughes is a postdoctoral researcher at St. Jude's Children's Hospital who studies the overlooked role of water in living systems. His work builds on a growing body of research suggesting that water is not just a passive solvent, but a highly structured, information-rich medium. Hughes proposes that under normal biological conditions, water's ability to form liquid crystalline phases, hydration shells, and coherent domains allows it to act more like an information storage system than an inert backdrop to biochemistry. Drawing on ideas like EZ water, interfacial water dynamics, and liquid-liquid phase separation inside cells that span thinkers from Gilbert Ling to Gerald Pollack, Hughes argues that health emerges from the fine-tuned electrical and structural properties of intracellular water. When this water-protein-electrical system breaks down, disease can result. He outlines a new approach to the body that's rooted in biophysics, not just molecular biology, which he believes might offer novel ways to maintain health and slow aging by restoring the electromagnetic coherence of the body.MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showPreprint of Michael's manuscript "Rethinking Cellular Organization: Phase Separation as a Unifying Principle in Molecular Biology" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5171413Dr. Thomas Seyfried podcast w/ DemystifyScihttps://www.youtube.com/watch?v=rxHkXP3G3y4"Live Streaming of a Single Cell's Life over a Local pH Monitoring Nanowire Waveguide" https://pubs.acs.org/doi/10.1021/acs.nanolett.2c02185Rudolf Steiner's Agriculture Course: https://www.youtube.com/watch?v=fwSa8Lpy9-A 00:00 Go! 00:09:54 – Water, Fields & the Electric Body 00:15:01 – Biochemistry's Unifying Principles 00:21:26 – Water, Glutamine & Metabolism 00:23:02 – Liquid-Liquid Phase Separation 00:25:34 – Hydration & Cellular Structure 00:28:08 – Amyloids in Health & Disease 00:33:52 – Environment Shapes Amyloids 00:39:37 – Osmosis, Metabolism & Flow 00:41:04 – Soil Over Seed: Health Revolution 00:42:24 – Evolving Scientific Paradigms 00:46:08 – Cell Theory & Liquid Separation 00:50:34 – Rethinking Genetic Primacy 00:56:12 – Biochemical Research Challenges 01:01:58 – Terrain Theory & Post-Pandemic Trust 01:13:16 – Technology, Ethics & Evolution 01:16:06 – Metabolism as Societal Metaphor 01:21:09 – Lifespan, Healthspan & Food Systems 01:23:25 – Terrain Theory & Neurodegenerative Disease 01:25:10 – pH, Buffers & Biochemical Balance 01:30:03 – Cellular Function & pH Dynamics 01:35:17 – Biochemical Cell Environment 01:39:06 – Intracellular Phase Separation 01:43:07 – Insulin, Gradients & Phase Transitions 01:45:12 – Water, Food & Environmental Impacts 01:48:14 – Personal Diet & Exercise Design 01:57:09 – Experimenting with Your Health 02:00:11 – Dyno comp! #electricuniverse #biochemistry, #structuredwater , #cellularhealth, #watermemory, #metabolism, #quantumhealth, #naturalmedicine, #integrativemedicine, #nutritionalscience, #epigenetics, #philosophypodcast, #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Bertram Bengsch and Dr Henrike Salie from the Department of Internal Medicine II, Medical Centre, University of Freiburg, Freiburg, Germany, on the paper "Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma" published in paper copy in Gut in March 2025.

Imagine a manufacturing environment where a single machine can take a product from raw material to a fully finished assembly—integrating multiple manufacturing tools into one seamless system. This vision of sustainable, on-site production is becoming a reality through an award-winning approach to single-cell manufacturing. On this episode of ASSEMBLY Audible, we're joined by an entrepreneur and innovator who is pushing the boundaries of additive manufacturing. Recently recognized as one of SME's 30 Under 30 recipients, Ethan Baehrend, CEO of Creative 3D, joins us to discuss his groundbreaking work in 3D printing.Sponsored By:

Osteosarcoma Webinar Series: Alexander Davies, DVM, PhD joins us on OsteoBites to discuss his work which is focused on dynamic tumor-microenvironment signaling cross-talk, signal integration, and the development of 3D organotypic and tissue models to study these interactions using live-cell microscopy techniques. Results from studies in the Davies Lab demonstrate the utility of a novel dynamic live-cell tissue model, the lungSITE model, to quantitatively measure and understand tumor signaling dynamics and behaviors within the context of the lung metastatic niche. Data obtained from this model provided new insights into how spatial position and temporal response influence signaling dynamics, specifically in osteosarcoma lung metastasis, to create intratumoral signaling heterogeneity and consequent single-cell drug response variation. Dr. Alexander Davies graduated with a Ph.D. in Biochemistry and Molecular Biology and a D.V.M., with an interest in comparative oncology, from the University of California, Davis. He then completed a post-doctoral fellowship in cancer biology at Lawrence Berkeley National Laboratory before joining The Ohio State University as faculty in the Department of Veterinary Biosciences. While at OSU he was a member of the Comprehensive Cancer Center and faculty in the Cancer Biology and Cancer Engineering programs. Currently, Dr. Davies is an Assistant Professor at the Knight Cancer Institute within the Division of Oncological Sciences and Cancer Early Detection Advanced Research Center (CEDAR) where his work focuses on dynamic tumor-microenvironment signaling cross-talk, signal integration, and the development of 3D organotypic and tissue models to study these interactions using live-cell microscopy techniques.

New research points to a rare cosmic event just 40 years ago that changes what we know about Uranus' magnetosphere. Also, scientists create a living, breathing mouse using ancient single-cell genes. Plus, on 'This Day in History'; smoking is banned on domestic flights in the US. Voyager 2's defining Uranus flyby may have been skewed by a rare cosmic event | CNN We've Only Been To Uranus Once And The Freak Timing May Have Misled Us For Years The anomalous state of Uranus's magnetosphere during the Voyager 2 flyby | Nature Astronomy Scientists recreate mouse from gene older than animal life Twenty-five Years Ago, U.S. Airlines Banned Smoking On Domestic Flights TDIH: Celebrating 25 Years of No Smoking in Airplanes – SEATCA Contact the show - coolstuffcommute@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Nels and Vincent review the identification of a novel virus associated with the pathogen Plasmodium knowlsei and which is part part of a diverse and unclassified viral taxon. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Virus associated with P. knowlsei (bioRxiv) Timestamps by Jolene Science Picks Nels – The peace of wild things, poem by Wendell Berry Vincent – All Life on Earth Today Descended From a Single Cell. Meet LUCA Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Caroline Alan is a health survivor and mineral enthusiast. Coming from a career in the corporate world, Caroline found herself struggling physically, mentally and energetically.  During her journey back to health, Caroline encountered plant-based minerals and their incredible ability to support a return to natural balance in the body.  As a result, she has become devoted to educating people about the benefits of mineral replenishment and the specific efficacy of plant-based humic and fulvic substances.   Caroline's research into why minerals are important in human physiology and how they work in the body, has taken her deep into microbiology, molecular biology, cellular biology, agricultural soil science and the study of plant decomposition. In the process, Caroline has found ways to help others understand the effects of mineral depletion and why plant-based humic and fulvic mineral supplementation support healing and optimal health.   Caroline is the Co-Founder & CEO of BEAM Minerals, which provides liquid humic and fulvic mineral supplements. “These humic and fulvic complexes, they're like Mother Nature's answer to mineral supplementation,” Caroline says.

In this episode of FYI, Brett Winton, ARK's Chief Futurist, and Nemo Marjanovic, ARK's Multiomics Analyst, have an in-depth discussion with Professor Nikolai Slavov from Northeastern University. Professor Slalov is the Director of Parallel Squared Technology Institute (PTI). Together they explore the fascinating and complex world of multiomics, focusing on the importance of proteomics in understanding biological processes. Professor Slavov shares his insights on the technological advancements in single-cell proteomics, the challenges in measuring protein interactions, and the critical role of proteomics in drug development. The conversation also delves into the underfunded nature of proteomics research and its potential to revolutionize biopharma R&D and diagnostics.Key Points From This Episode:Introduction to multi-omics and its relevance in modern biology.Explanation of the central dogma of molecular biology: DNA, RNA, and proteins.Overview of Professor Slavov's research on single-cell proteomics and its implications.Challenges in measuring the dynamic and complex nature of the proteome.The role of advanced technologies like mass spectrometry in proteomic analysis.Importance of protein interactions and modifications in cellular functions.Discussion on the underfunding of proteomics research and its impact on scientific progress.The potential of proteomics to improve drug development and diagnostic precision.Advances in AI and data analysis techniques for better understanding protein structures and functions.Future frontiers in proteomics, including improved technology access and dynamic protein measurements.References:MacCoss, M.J., Alfaro, J.A., Faivre, D.A. et al. Sampling the proteome by emerging single-molecule and mass spectrometry methods. Nat Methods 20, 339–346 (2023). https://doi.org/10.1038/s41592-023-01802-5 Derks J, Jonson T, Leduc A, Khan S, Khoury L, Rafiee M, Slavov N Single-nucleus proteomics identifies regulators of protein transportbioRxiv  doi: 10.1101/2024.06.17.599449 (2024)

Relation leverages single-cell multi-omics, functional assays, and machine learning to better characterize diseases and develop transformational medicines.

This week on Data in Biotech, we are joined by Parul Bordia Doshi, Chief Data Officer at Cellarity, a company that is leveraging data science to challenge traditional approaches to drug discovery.  Parul kicks off the conversation by explaining Cellarity's mission and how it is using generative AI and single-cell multiomics to design therapies that target the entire cellular system, rather than focusing on single molecular targets. She gives insight into the functionality of Cellarity Maps, the company's cutting-edge visualization tool that maps the progression of disease states and bridges the gap between biologists and computational scientists.  Along with host Ross Katz, Parul walks through some of the big challenges facing Chief Data Officers, particularly for biotech organizations with data-centric propositions. She emphasizes the importance of robust data frameworks for validating and standardizing complex data sets, and looks at some of the practical approaches that ensure data scientists can derive the maximum amount of value from all available data.  They discuss what data science teams look like within Cellarity, including the unique way the company incorporates human intervention into its processes. Parul also emphasizes the benefits that come through hiring multilingual, multidisciplinary teams and putting a strong focus on collaboration.  Finally, we get Parul's take on the future of data science for drug discovery, plus a look at Cellarity's ongoing collaboration with Novo Nordisk on the development of novel therapeutics.  Data in Biotech is a fortnightly podcast exploring how companies leverage data innovation in the life sciences. Chapter Markers [1:45] Introduction to Parul, her career journey, and Cellarity's approach to drug discovery. [5:47] The life cycle of data at Cellarity from collection to how it is used by the organization.  [7:45] How the Cellarity Maps visualization tool is used to show the progression of disease states [9:05] The role of a Chief Data Officer in aligning an organization's data strategy with its company mission.   [11:46] The benefits of collaboration and multidisciplinary, cross-functional teams to drive innovation.  [14:53] Cellarity's end-to-end discovery process; including how it uses generative AI, contrastive learning techniques, and visualization tools.  [19:42] The role of humans vs the role of machines in scientific processes.  [23:05] Developing and validating models, including goal setting, benchmarking, and the need for collaboration between data teams and ML scientists. [30:58] Generating and managing massive amounts of data, ensuring quality, and maximizing the value extracted. [37:08] The future of data science for drug discovery, including Cellarity's collaboration with Novo Nordisk to discover and develop a novel treatment for MASH.

Part 3 of 4. My guest for this week's episode is Noam Solomon, CEO and co-founder at Immunai, a pioneering biotech company that is comprehensively mapping and reprogramming the immune system with single-cell biology and AI to power new therapeutic discoveries, accelerate drug development, and improve patient outcomes.

In this week's episode of the Everything Epigenetics podcast, Dr. Hannah Went sits down with Alex Trapp, a computational biologist deeply involved in aging research. The two explore the cutting-edge development of single-cell epigenetic clocks and their potential applications in the field of longevity science. Alex shares his journey from experimental biology to computational approaches and discusses the significant implications of understanding aging at the single-cell level. He also provides insights into his work at Retro Biosciences, a company focused on extending healthy human lifespan through innovative therapies. In this episode of Everything Epigenetics, you'll learn about: • The development and significance of single-cell epigenetic clocks • Differences between bulk tissue and single-cell epigenetic sequencing methods • Applications of single-cell aging clocks in understanding and potentially reversing aging • Challenges and future directions in single-cell epigenetic research • The exciting work being done at Retro Biosciences, including advancements in T-cell rejuvenation and plasma therapeutics Chapters: 00:00 Introduction 03:15 Alex Trapp's journey in the aging research field 07:35 Overview of epigenetic clocks and single-cell approaches 17:38 Development and challenges of the single-cell aging clock 22:41 Applications and implications of single-cell clocks in aging research 35:57 Future directions in epigenetic research 42:55 Alex's work at Retro Biosciences and its potential impact Review Alex's Study: https://pubmed.ncbi.nlm.nih.gov/36211119/ Support the Show: https://www.buzzsprout.com/2084028/support Thank you for joining us at the Everything Epigenetics Podcast, and remember, you have control over your epigenetics, so tune in next time to learn more about how. Support the Show.Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.

Send us a Text Message.Curious about the latest innovations in cell analysis technology? Join us in this episode with Furkan Gökçe, New Business Development Manager at Amphasys, as we delve into the fascinating world of Impedance Flow Cytometry (IFC).Furkan shares how IFC is revolutionizing single-cell analysis by providing faster, more precise, and high-resolution data.Key Takeaways:Real-Time Precision: Discover how IFC allows for real-time, label-free assessments of cells, providing detailed insights into their natural state.Enhanced Process Control: Learn how IFC can detect early signs of nutrient deficiencies and contaminants, leading to timely interventions and improved bioreactor outcomes.Versatile Applications: Hear about practical applications, from brewing to protein production, where IFC has significantly boosted yields and process efficiency.Tune in to uncover how IFC is set to transform the landscape of bioprocessing, ensuring better quality and sustainability in biologics production.Connect with Furkan Gökçe:LinkedIn: https://www.linkedin.com/in/furkangokceAmphasys: https://amphasys.com/bioprocessingNext Steps:Book a free assessment to help you get started with the implementation of new technologies in your manufacturing processes: https://bruehlmann-consulting.comDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

Send us a Text Message.Ever wondered how single-cell analysis could revolutionize bioprocessing? Join us in this episode as we delve into the cutting-edge world of impedance flow cytometry.Furkan Gökçe, New Business Development Manager at Amphasys, shares his insights on the transformative power of this technology in the biotech industry. With a background in engineering and physics, Furkan provides a unique perspective on tackling the complexities of biological systems.Key Takeaways:Enhanced Process Control: Learn how impedance flow cytometry offers high-resolution, label-free analysis of individual cells, ensuring optimal growth conditions and quality production.Understanding Cell Heterogeneity: Discover the importance of single-cell analysis in revealing critical variations within cell populations that bulk measurements often miss.Innovation in Bioprocessing: Explore the advancements in microfabrication techniques that make real-time, high-throughput cell analysis possible, revolutionizing bioprocessing efficiency and accuracy.Tune in to gain valuable knowledge on how this innovative technology can enhance your bioprocess development and manufacturing strategies!Connect with Furkan Gökçe:LinkedIn: https://www.linkedin.com/in/furkangokceAmphasys: https://amphasys.com/bioprocessingNext Steps:Book a free assessment to help you get started with the implementation of new technologies in your manufacturing processes: https://bruehlmann-consulting.comDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

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The body of 27-year-old mother of two, Samantha Bodsworth, was found in Noosa, surrounded by wattle trees. The killer thinks it's the perfect crime, but what they underestimated was the power of the tiny, silent witnesses clinging to almost everything they touched – pollen. In this episode, Dr Lynne Milne, the scientist at the forefront of forensic palynology, reveals how, for the first time in an Australian criminal case, pollen helped unmask a murderer. This episode references men's violence against women. If you or someone you know is experiencing, or at risk of experiencing, domestic, family or sexual violence, call 1800RESPECT on 1800 737 732, text 0458 737 732 or visit 1800RESPECT.org.au for online chat and video call services. The number for Life Line is 13 11 14.See omnystudio.com/listener for privacy information.

Part 3 of 4. My guest for this week's episode is Quin Wills, CSO and Co-Founder of Ochre Bio, a pioneering biotechnology company developing RNA therapies for chronic liver diseases. Using a combination of genomic deep phenotyping, precision RNA medicine, and testing in live human donor livers, Ochre is developing therapies for liver health challenges ranging from increasing donor liver supply to reducing cirrhosis complications.

In this episode of the Epigenetics Podcast, we talked with Ana Cvejic from the Biotech Research & Innovation Centre at the University of Copenhagen about her work on using sc-multiomics to characterise human developmental hematopoiesis. The conversation starts by delving into Ana's research on hematopoiesis, starting with her work on identifying novel genes controlling blood traits in zebrafish models. She explains her transition to single-cell methodologies and the application of single-cell RNA sequencing to study hematopoietic cells in zebrafish, focusing on thrombocyte lineage commitment and gene expression. The discussion progresses to her groundbreaking study on human fetal hematopoiesis, where she combined single-cell RNA-seq with single-cell ATAC-seq to understand chromatin accessibility and gene expression dynamics. Ana then shares insights into the identification of new cell surface markers and the priming of hematopoietic stem cells, particularly in conditions like Down syndrome. Furthermore, she then elaborates on the construction of a phylogenetic tree of blood development using whole-genome sequencing of single-cell-derived hematopoietic colonies from healthy human fetuses. She explains the motivation behind this study, highlighting the insights gained regarding stem cell quantities, developmental timelines, and mutations in blood development. References Bielczyk-Maczyńska, E., Serbanovic-Canic, J., Ferreira, L., Soranzo, N., Stemple, D. L., Ouwehand, W. H., & Cvejic, A. (2014). A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. PLoS genetics, 10(7), e1004450. https://doi.org/10.1371/journal.pgen.1004450 Athanasiadis, E. I., Botthof, J. G., Andres, H., Ferreira, L., Lio, P., & Cvejic, A. (2017). Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Nature communications, 8(1), 2045. https://doi.org/10.1038/s41467-017-02305-6 Ranzoni, A. M., Tangherloni, A., Berest, I., Riva, S. G., Myers, B., Strzelecka, P. M., Xu, J., Panada, E., Mohorianu, I., Zaugg, J. B., & Cvejic, A. (2021). Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis. Cell stem cell, 28(3), 472–487.e7. https://doi.org/10.1016/j.stem.2020.11.015   Related Episodes Single Cell Epigenomics in Neuronal Development (Tim Petros) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro) Single-Cell Technologies using Microfluidics (Ben Hindson)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

These little critters are often seen on the beach, they are the worlds largest single cell organism and they can get up to the size of a softball!

BUFFALO, NY- March 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer's disease by activated protein C.” Single-Cell RNA sequencing reveals changes in cell population in Alzheimer's disease (AD) model 5xFAD (5x Familial AD mutation) versus wild type (WT) mice. In this new study, researchers Mohammad Kasim Fatmi, Hao Wang, Lily Slotabec, Changhong Wen, Blaise Seale, Bi Zhao, and Ji Li from the University of South Florida, University of Mississippi Medical Center and the G.V. (Sonny) Montgomery VA Medical Center used single-cell RNA sequencing and bioinformatic analysis to analyze the effects of APC [Activated Protein C] treatment on AD transgenic mice. “In our investigation, we utilized transgenic mice that contain expression for five major amyloid pathologies that allow for rapid progression of AD and Aβ deposition known as 5xFAD mice.” The returned sequencing data was processed through the 10x Genomics CellRanger platform to perform alignment and form corresponding matrix to perform bioinformatic analysis. Alterations in glial cells occurred in 5xFAD versus WT, especially increases in microglia proliferation were profound in 5xFAD. Differential expression testing of glial cells in 5xFAD versus WT revealed gene regulation. Globally, the critical genes implicated in AD progression are upregulated such as Apoe, Ctsb, Trem2, and Tyrobp. Using this differential expression data, GO term enrichment was completed to observe possible biological processes impacted by AD progression. Utilizing anti-inflammatory and cyto-protective recombinant Activated Protein C (APC), the researchers uncovered inflammatory processes to be downregulated by APC treatment in addition to recuperation of nervous system processes. Moreover, animal studies demonstrated that administration of recombinant APC significantly attenuated Aβ burden and improved cognitive function of 5xFAD mice. “The downregulation of highly expressed AD biomarkers in 5xFAD could provide insight into the mechanisms by which APC administration benefits AD.” DOI - https://doi.org/10.18632/aging.205624 Corresponding authors - Bi Zhao - bizhao@usf.edu, and Ji Li - jli3@umc.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205624 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, APC, Alzheimer's disease, inflammation About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Episode 11 - Innovations in Vaccine Research: Single Cell Immunity Development With Dr Fabian Otte Recorded Live from CROI 2024In this podcast episode, Dr Michael Saag converses with Dr Fabian Otte, a molecular biologist at the University of Basel in Switzerland, live from the 2024 Conference on Retroviruses and Opportunistic Infections (CROI). Dr Otte shares insights into the ongoing development of an innovative SARS-CoV-2 vaccine that employs a single-cell immunity development approach. Highlighting its potential benefits, such as broader and longer-lasting immunity compared with mRNA vaccines. This pioneering vaccine research might also extend to other RNA viruses in the future. 00:02 Introduction to the Podcast and Guest 00:28 Discussion on the Development of Next-Generation SARS-CoV-2 Vaccines 00:50 Exploring a Single-Cell Immunity Approach 01:10 Understanding the Vaccine Development Process 02:42 The Potential of the New Vaccine 03:13 Challenges and Advantages of the New Vaccine 05:07 The Impact of the Vaccine on Immune Response__________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTube InstagramTikTok...

We are all the product of a reproductive process, yet reproductive biology, or the study of the processes and mechanisms involved in reproduction, is not well understood. Deepening our understanding of reproductive biology is crucial to advancing assistive reproductive technologies (ART) and advancing our collective comprehension of inheritance and evolution. Our guests for this episode are a couple, and we mean a literal married couple, of reproductive biology experts. Dr. Pavla Brachova and Dr. Nehemiah Alvarez, both working in the Eastern Virginia Medical School's Department of Physiological Sciences. In their collaborative work they aim to better understand and characterize the role of RNA and cellular events that impact ovarian function in women. We learn about their work with oocytes, which are single cells that grow and mature within the ovary and once fertilized provide the foundations of an embryo capable of maturing to a new individual. They outline how they use digital PCR (dPCR) and other methods to monitor RNA regulation in single cells and how progressing this work and lead to potential RNA-based therapies. In Cassie's career corner we hear childhood stories from each guest and learn about their respective career paths, which eventually collided and merged. They share insights on the importance of having mentors experienced in your field, the challenges of shared job searching, and the joys of collaborating as a couple with shared scientific interests.Visit the Absolute Gene-ius page to learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

Today, I am blessed to have here with me Caroline Alan. Dan Howard and Caroline Alan founded BEAM Minerals as a vehicle for promoting the amazing power of plant-based fulvic and humic minerals. Their personal experiences using these completely natural substances transformed their health and their understanding of healing. As a result of their experiences, Dan and Caroline are committed to providing completely pure, 100% bioavailable, sustainably produced, fulvic, and humic products. In this episode, Caroline Alan explains everything you need to know about minerals. Did you know that every single cell in your body requires minerals? Unfortunately, most people are mineral depleted. Caroline explains why you may be suffering from mineral deficiency and not getting enough minerals from the foods you eat. Luckily, Caroline reveals how you can replenish minerals through her products like Micro-BOOST, Electrolyze, and Insta-Lytes. Tune in as we chat about avoiding period symptoms with minerals, what you need to know about minerals on a carnivore diet, and why Caroline recommends liquid plant-based minerals.  Get Beam Mineral products here: www.beamminerals.com/ketokamp use the code ketokamp for 20% off your entire order. 

There are very few remaining locations on Earth that are untouched by humans, and those that do remain are in very extreme environments that are difficult to access.  However, accessing and studying life in these extreme environments can provide unique insights to the biology of life. Understanding how simple organisms adapt and survive in seemingly unlivable conditions is a unique field of study with the potential to inform and affect the human condition.  We're joined in this episode by Dr. Brandi Kiel Reese and Lydia Hayes-Guastella from the Dauphin Island Sea Lab at the University of South Alabama. They are both geomicrobiologists that study microbial life in extreme environments like the Mariana Trench and Antarctica.  They do an excellent job of painting a picture of how extreme conditions are in these environments and how they manage to collect and preserve samples from such harsh conditions. We learn about the various methods they use to analyze the microbial samples they collect, including the use of digital PCR (dPCR) to detect and quantify transcripts that would otherwise not be detectable given how few cells they're able to collect.   Brandi and Lydia also share their unpredictable career path journeys, while sharing some insights and learnings from their respective experiences. We learn what they each love about their work and what qualities is takes to be successful at what they do. Once again, we're reminded of what a small world it is, especially when you're in a specialty field such as geomicrobiology of extreme environments.   Visit the Absolute Gene-ius page to learn more about the guest, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

This week's EYE ON NPI is going to fuel up your portable battery-powered designs with the Texas Instruments BQ27427 System-Side Impedance Track™ Single-Cell Battery Fuel Gauge (https://www.digikey.com/en/product-highlight/t/texas-instruments/bq27427-single-cell-battery-fuel-gauge) a powerful and inexpensive way to add high quality battery monitoring for charge-rate and aging tracking at the system side. Lithium Ion / Polymer batteries (https://www.digikey.com/en/products/filter/batteries-rechargeable-secondary/91) - you love them for their low cost, high power density, and 3.7V nominal voltage, but keeping them recharged and letting people know exactly how much battery life is left is non-trivial. Like most batteries, common LiPoly/LiIon's start with a high peak voltage right after charging of about 4.2V, drop quickly to about 3.7V and then slowly drift down till they get to 3.0V at which point the cut-off circuitry disconnects until they are recharged. It's really easy to tell when the battery is 90% or greater charge, just look for a voltage of 3.9V or higher. It's also pretty easy to tell when they're 10% or less, the voltage will be 3.3V or lower. But that in-between section is tough because the slope during discharge is very shallow and the voltage changes quite a bit with aging, temperature, and discharge rate (https://www.ti.com/lit/an/snva533/snva533.pdf) So while there are battery monitors that can use just the voltage across the battery terminals, they're not going to be as precise as a coulomb-counter design that takes into account both voltage and current. From TI's White Paper on the topic (https://www.ti.com/lit/wp/slpy002/slpy002.pdf): "An impedance-based battery fuel gauge, as the name implies, uses the measured impedance of the battery's cells as a key input to its remaining capacity predictions. The gauge measures and stores in real-time the battery pack's resistance as a function of state-of-charge. The real-time resistance profiles along with the stored battery open-circuit voltage tables (open-circuit voltage vs. state-of-charge) enables the gauge to predict the battery pack's discharge curve (by adjusting for the IR drop) under any system-use condition and temperature. The algorithm uses current integration (coulomb counting) when the system is ON, and open-circuit voltage measurement when the system is OFF or in SLEEP to adjust remaining state-of-charge (RSOC) up or down (for charge or discharge) the predicted discharge curve. By using the predicated discharge curve, the gauge can accurately calculate the battery pack's remaining discharge capacity (RM) and the system's run-time to empty (RTTE). Since an impedance track gauge continuously adjusts RM and FCC for impedance and the change in impedance, rate and temperature inefficiencies and aging are inherently taken into account, enabling the gauge to maintain a high level of accuracy throughout the life of the system." Texas Instruments has a few chips in the Impedance Track family (https://www.ti.com/video/6287050244001) - the BQ27427 charger (https://www.digikey.com/en/products/detail/texas-instruments/BQ27427YZFR/17748369) is the latest to come out. It's very small, coming as a 9-pin 1.6x1.6 BGA with the center pad being a shared ground so you don't need plugged vias to use. It's also really easy to use, requiring only 2 small stabilization capacitors. Internal temperature monitoring means you don't need a separate thermistor. The high-side 7 mΩ current sense resistor also means one less part on the BOM. I2C pins are used to communicate with the monitor and set battery characteristics. There's also an optional input that can be used to connect to a mechanical or electrical battery insertion switch or to an external thermistor, and an optional output that can be used as a battery low indicator. Because so much is integrated, and the chip is so small, its very easy to pop it into your design between the battery terminal and the VBAT lines that go to your battery charger and power supply. The peak battery voltage and capacity are easy to look up since they're written on the battery. For other configuration settings you can use BQStudio / GaugeStudio (https://www.ti.com/tool/BQSTUDIO) with the TI battery devboard to characterize and customize the learning cycle. Either way, you will need to write the configuration to the sensor on every boot. Pick up the Texas Instruments BQ27427 (https://www.digikey.com/short/18pb1ftw) and other chips from the Impedance Track family (https://www.digikey.com/en/products/result?s=N4IgjCBcoLQCxVAYygMwIYBsDOBTANCAG4B2aWehA9lANrhwCsAnBALqEAOALlCCAF8hQA0) stocked at DigiKey for immediate shipment. Order today and you'll get precision lipoly monitoring that will work with any setup or battery configuration by tomorrow afternoon!